Hub : Genes

LOC102553078

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC102553078	0.04	0.03	5.1e-03	0.02	0.02	0.01	0.03	1.0e-02	3.3e-03	1.8e-02	1.8e-03
2	PL	gene expression	LOC102553078	0.03	0.02	6.5e-03	0.02	0.01	0	0.01	4.3e-03	2.1e-02	1.7e-01	1.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.1	0.2	0.2	-0.3	0.5
Area under the delay curve	0.0	0.0	0.0	0.1	-0.2
BMI with tail	0.0	0.2	0.3	0.1	-0.6
BMI without tail	2.4	5.0	7.4	1.6	-2.7
Body weight	1.2	5.1	8.7	1.2	-2.9
Weight adjusted by age	1.6	1.8	2.4	1.1	-1.6
Bone surface	0.7	1.3	2.0	1.4	-0.7
Bone volume	0.4	0.7	1.1	1.0	-0.5
Breakpoint value in progressive ratio session	0.2	0.2	0.3	-0.6	0.2
Number of licking bursts	2.1	2.5	5.0	-2.2	0.1
Context. condit. distance diff. score	1.3	1.5	2.7	1.7	0.5
Locomotion velocity, session 1	0.7	0.8	1.2	-0.6	1.1
Locomotion distance, session 1	0.2	0.3	0.3	0.5	0.5
Locomotion velocity, session 2	0.0	0.1	0.1	0.1	-0.3
Locomotion distance, session 2	0.1	0.2	0.3	0.6	0.1
Locomotion velocity, session 3	0.3	0.3	0.5	0.4	0.7
Locomotion distance, session 3	0.6	0.6	0.9	0.6	1.0
Stereotopy head waving bouts, day 3	0.2	0.2	0.3	-0.3	-0.6
Stereotopy head waving duration, day 3	0.1	0.1	0.1	0.4	0.3
Locomotion velocity, session 7	0.4	0.4	0.6	-0.8	0.5
Locomotion distance, session 7	0.0	0.0	0.1	-0.2	-0.0
Stereotopy head waving bouts, day 7	0.8	0.8	1.7	1.3	0.1
Stereotopy head waving duration, day 7	1.3	1.6	3.1	1.8	-0.4
Locomotion velocity, session 8	0.7	0.8	1.6	1.3	-0.1
Locomotion distance, session 8	1.0	1.4	2.8	1.7	0.1
Degree of sensitization distance	1.4	1.4	2.8	0.0	-1.7
Degree of sensitization stereotypy	1.7	1.9	3.7	1.9	0.1
Conditioned locomotion	0.3	0.4	0.6	-0.4	0.7
Cocaine response after cond. corrected	0.8	1.0	1.5	-1.2	-0.6
Cocaine response after cond. not corrected	0.3	0.3	0.6	-0.8	-0.3
Cocaine response before conditioning	0.6	0.8	1.2	1.1	0.6
Saline control response	1.8	2.4	2.8	1.7	-1.4
Bone: connectivity density	0.2	0.3	0.5	0.1	0.7
Bone: cortical apparent density	0.3	0.4	0.6	-0.7	-0.5
Bone: cortical area	0.8	1.2	1.2	1.1	-1.1
Bone: cortical porosity	0.3	0.3	0.4	0.5	0.6
Bone: cortical porosity	0.3	0.3	0.5	0.4	0.7
Bone: cortical thickness	0.0	0.1	0.1	-0.3	0.2
Bone: cortical thickness	0.0	0.0	0.0	-0.0	0.1
Bone: cortical tissue density	0.3	0.4	0.6	-0.8	-0.4
Condit. Reinf. active minus inactive responses	0.7	0.8	1.1	0.7	-1.1
Condit. Reinf. active-inactive response ratio	1.6	1.8	2.0	1.3	-1.4
Condit. Reinf. active responses	0.1	0.2	0.3	0.2	-0.6
Condit. Reinf. inactive responses	0.2	0.2	0.2	-0.5	0.4
Incentive salience index mean	0.7	0.8	1.0	0.8	-1.0
Condit. Reinf. lever presses	0.1	0.2	0.2	0.5	-0.4
Condit. Reinf. active minus inactive responses	6.1	7.6	10.8	3.3	-2.1
Condit. Reinf. active-inactive response ratio	0.9	1.0	1.6	1.3	-0.5
Condit. Reinf. active responses	9.2	12.7	16.5	4.1	-3.0
Condit. Reinf. inactive responses	6.6	8.1	9.3	3.1	-2.6
Condit. Reinf. lever presses	12.2	16.6	27.3	5.2	-2.4
Condit. Reinf. lever reinforcers received	9.5	13.3	18.4	4.3	-2.9
Conditioned reinforcement - actives	0.6	0.6	0.7	0.7	0.9
Conditioned reinforcement - inactives	0.1	0.1	0.2	-0.4	0.2
Conditioned locomotion	0.7	0.8	1.5	0.4	1.2
Patch foraging indifference point 0 sec	3.2	5.2	9.4	3.1	-1.0
Patch foraging indifference point AUC	0.6	0.7	1.1	0.5	-1.0
Delay disc. indifference point, 0s delay	1.0	1.1	1.6	1.3	-0.8
Delay disc. indifference point, 16s delay	0.3	0.3	0.3	-0.5	0.5
Delay disc. indifference point, 2s delay	0.9	1.0	1.6	1.3	-0.6
Delay disc. indifference point, 24s delay	0.6	0.6	1.2	-1.1	0.0
Delay disc. indifference point, 4s delay	1.8	1.9	2.0	1.4	-1.3
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.5	-0.1
Indifference point function ln k	0.6	0.9	1.2	0.7	1.1
Indifference point function log k	0.6	0.9	1.2	0.7	1.1
Patch foraging total patch changes 0 sec	2.5	4.1	7.3	2.7	-0.9
Patch foraging total patch changes 12 sec	2.3	3.0	3.4	1.8	-1.6
Patch foraging total patch changes 18 sec	2.6	3.3	4.9	2.2	-1.3
Patch foraging total patch changes 24 sec	0.6	0.8	0.9	0.9	-0.8
Patch foraging total patch changes 6 sec	0.5	0.8	1.5	1.2	0.0
Patch foraging time to switch 0 sec	2.9	4.4	6.8	-2.6	1.4
Patch foraging water rate 0 sec	1.8	2.9	5.1	2.3	-0.9
Patch foraging water rate 12 sec	0.8	1.2	2.3	1.5	0.2
Patch foraging water rate 18 sec	0.5	0.7	1.2	1.1	-0.5
Patch foraging water rate 24 sec	0.6	0.8	1.3	0.5	1.1
Patch foraging water rate 6 sec	0.2	0.3	0.4	0.7	0.4
Seeking ratio, delayed vs. immediate footshock	1.3	1.5	2.6	-1.6	0.5
Distance traveled before self-admin	0.3	0.3	0.5	-0.7	0.0
Distance traveled after self-admin	1.9	2.1	2.2	-1.5	1.5
Extensor digitorum longus weight	0.3	1.2	2.4	0.3	-1.5
Bone: elastic displacement	2.0	2.3	3.4	-1.8	1.1
Bone: elastic work	2.3	3.0	4.0	-2.0	1.4
Bone: endosteal estimation	2.0	4.3	4.8	1.9	-2.2
Bone: endosteal perimeter	2.2	4.6	5.0	2.2	-2.0
Epididymis fat weight	0.8	2.0	3.9	-0.2	-2.0
Delta time in closed arm before/after self-admin	1.3	1.3	2.5	0.0	-1.6
Delta time in open arm before/after self-admin	1.7	1.6	2.7	1.6	-0.8
Diff in mean of infusions in LGA sessions	1.4	1.6	3.0	-1.7	0.5
Delay discount exponential model param	0.0	0.0	0.1	-0.1	0.2
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.2	-0.4
Active lever presses in extinction session 6	1.2	1.2	1.3	1.1	1.0
Bone: final force	0.0	0.0	0.1	0.2	-0.2
Bone: final moment	0.1	0.2	0.2	0.5	-0.3
Food consumed during 24 hour testing period	1.6	1.9	3.8	2.0	-0.2
Glucose	0.1	0.1	0.2	-0.0	0.4
Heart weight	0.7	1.0	1.8	1.4	-0.2
Delay discount hyperbolic model param	0.2	0.2	0.2	-0.4	0.5
Intermittent access intake day 1-15 change	0.9	0.9	1.5	1.2	0.5
Intermittent access intake escalation	1.2	1.2	2.1	1.4	0.5
Intermittent access intake escalation 2	0.1	0.1	0.2	0.4	-0.1
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.1	-0.3	0.0
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.2	0.2	0.4
Intermitt. access escalation Index	0.3	0.3	0.6	0.7	-0.2
Intermittent access day 1 total infusions	0.4	0.5	0.7	0.6	-0.8
Intermittent access day 15 total infusions	1.0	1.1	2.2	1.5	0.0
Intermittent access terminal intake (last 3 days)	0.6	0.6	1.1	1.1	-0.3
Intermittent access total infusions	0.2	0.2	0.3	0.6	-0.4
Intermittent access day 1 locomotion	0.1	0.1	0.2	-0.5	0.3
Intermittent access day 15 total locomotion	0.2	0.2	0.3	0.5	0.4
Intermittent access total locomotion	0.0	0.1	0.1	0.3	-0.1
Intermittent access standard deviation	0.1	0.1	0.3	0.1	-0.5
Left kidney weight	1.9	5.2	5.3	2.3	-2.3
Right kidney weight	1.3	3.6	4.1	1.7	-2.0
Cocaine induced anxiety	0.3	0.3	0.4	-0.7	0.4
Post-drug Anxiety	0.3	0.3	0.6	-0.8	0.0
Baseline Anxiety	0.3	0.3	0.4	0.6	-0.5
Tail length	5.4	16.4	22.0	3.3	-4.7
Length with tail	2.4	8.9	14.2	1.9	-3.8
Length without tail	0.4	1.0	1.5	-1.2	0.6
Times rat made contact with spout	0.4	0.4	0.8	0.0	-0.9
Lifetime Intake	0.3	0.3	0.6	0.7	-0.3
Liver weight, left	0.9	1.4	2.8	-0.2	-1.7
Liver weight, right	1.8	2.9	5.3	-0.8	-2.3
Locomotor activity	0.5	0.7	1.5	1.2	-0.1
Locomotor testing distance	1.8	3.0	4.9	2.2	-1.1
Locomotor testing rearing	1.7	2.7	3.0	1.5	-1.7
Locomotion in novel chamber	0.4	0.5	0.7	0.5	0.8
Locomotion in novel chamber post-restriction	0.9	1.1	1.4	0.9	1.2
Fecal boli incidents, locomotor time 1	0.2	0.3	0.5	0.7	0.3
Change in fecal boli incidents, locomotor task	0.8	0.8	1.4	-1.2	0.4
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.8	0.9	0.3
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.5	-0.0
Total resting periods, locomotor time 1	0.1	0.1	0.3	-0.0	0.5
Rest time, locomotor task time 1	0.5	0.5	0.5	-0.7	0.7
Distance moved, locomotor task time 1	1.4	1.5	1.9	1.0	-1.4
Vertical activity count, locomotor time 1	1.4	1.5	2.1	1.4	-0.9
Time >=10cm from walls, locomotor time 2	0.9	1.0	1.1	1.1	-0.9
Bouts of movement, locomotor time 2	0.3	0.3	0.4	0.6	-0.5
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.4	-0.3
Rest time, locomotor task time 2	1.6	1.8	3.1	-1.7	0.7
Distance moved, locomotor task time 2	2.8	3.3	4.4	2.1	-1.5
Vertical activity count, locomotor time 2	2.6	2.8	3.1	1.8	-1.6
Light reinforcement 1	0.9	1.7	3.2	-1.8	0.4
Light reinforcement 2	0.1	0.2	0.2	-0.5	0.3
Bone: marrow area	1.8	3.8	4.5	1.8	-2.1
Bone: maximum diameter	2.1	3.8	4.7	2.2	-1.7
Bone: maximum force	0.1	0.2	0.3	0.5	-0.3
Bone: maximum moment	0.2	0.4	0.6	0.8	-0.5
Mean time between licks in bursts	7.6	10.7	11.3	3.4	-3.2
Mean num. licks in bursts	2.2	2.6	5.0	2.2	-0.4
Cd content in liver	0.5	0.5	0.8	-0.4	-0.9
Co content in liver	2.4	2.8	3.2	1.8	-1.6
Cu content in liver	1.5	1.8	2.2	1.2	-1.5
Fe content in liver	0.0	0.0	0.0	0.1	-0.2
K content in liver	0.1	0.1	0.2	-0.2	-0.4
Mg content in liver	0.1	0.1	0.2	0.4	-0.3
Mn content in liver	2.5	2.9	3.1	-1.8	1.6
Na content in liver	0.1	0.2	0.2	0.4	0.4
Rb content in liver	0.9	1.1	1.6	1.2	-0.8
Se content in liver	2.8	3.4	5.5	-2.4	1.1
Sr content in liver	0.3	0.3	0.5	-0.2	0.7
Zn content in liver	3.5	3.9	6.6	2.6	-1.1
Bone: minimum diameter	1.9	3.6	5.4	1.3	-2.3
Time in familiar zone, hab. session 1	0.2	0.2	0.4	0.1	-0.6
Time in novel zone, hab. session 1	0.0	0.0	0.1	-0.3	0.0
Total zone transitions, hab. session 1	0.5	0.7	1.4	0.0	1.2
Total locomotion distance, hab. session 1	0.4	0.5	1.0	-0.2	-1.0
Locomotion velocity, hab. session 1	0.2	0.3	0.5	-0.1	-0.7
Time in familiar zone, hab. session 2	1.8	1.8	2.8	1.7	-1.0
Time in novel zone, hab. session 2	0.8	0.8	1.1	-1.0	0.7
Total zone transitions, hab. session 2	0.5	0.6	0.9	1.0	0.6
Total locomotion distance, hab. session 2	1.0	1.3	2.4	0.4	-1.5
Locomotion velocity, hab. session 2	1.0	1.4	2.7	0.3	-1.7
Novel to familiar place preference ratio	0.0	0.0	0.0	-0.1	0.2
Novelty place preference	0.0	0.0	0.0	-0.1	0.1
Time in novel zone, NPP test	0.0	0.0	0.0	0.1	0.1
Total zone transitions, NPP test	0.1	0.2	0.3	-0.0	0.6
Total locomotion distance, NPP test	0.6	0.8	1.3	-0.5	-1.1
Locomotion velocity, NPP test	0.6	0.9	1.0	-0.9	-1.0
Intraocular pressure	0.5	0.7	1.4	0.2	1.2
Delta distance traveled before/after self-admin	0.4	0.5	0.9	-0.1	1.0
Delta ambulatory time before/after self-admin	0.8	0.8	1.7	-0.2	1.3
Parametrial fat weight	0.3	0.5	0.9	-0.4	-0.9
Pavlov. Cond. lever latency	1.3	1.6	2.6	-1.6	0.8
Pavlov. Cond. magazine entry latency	2.8	3.7	5.3	2.3	-1.4
Pavlov. Cond. change in total contacts	1.2	1.3	1.8	1.3	-0.9
Pavlov. Cond. index score	3.2	4.1	5.9	2.4	-1.5
Pavlov. Cond. latency score	3.0	3.8	5.7	2.4	-1.4
Pavlov. Cond. lever contacts	1.8	2.2	2.8	1.7	-1.2
Pavlov. Cond. magazine entry number	3.1	3.9	6.3	-2.5	1.2
Pavlov. Cond. intertrial magazine entries	1.2	1.5	2.6	-1.6	0.7
Pavlov. Cond. lever-magazine prob. diff.	2.6	3.2	4.6	2.2	-1.4
Pavlov. Cond. response bias	1.6	2.0	2.6	1.6	-1.1
Pavlov. Cond. lever latency	11.5	15.5	26.3	-5.1	2.2
Pavlov. Cond. magazine entry latency	2.1	2.5	4.8	2.2	-0.2
Pavlov. Cond. change in total contacts	7.8	10.8	19.1	4.4	-1.6
Pavlov. Cond. index score	8.7	11.1	19.8	4.4	-1.6
Pavlov. Cond. latency score	7.5	9.3	16.7	4.1	-1.3
Pavlov. Cond. lever contacts	12.0	16.4	28.1	5.3	-2.2
Pavlov. Cond. magazine entry number	3.7	4.5	8.8	-3.0	0.5
Pavlov. Cond. intertrial magazine entries	1.0	1.4	2.4	0.5	-1.6
Pavlov. Cond. lever-magazine prob. diff.	8.5	10.8	18.7	4.3	-1.7
Pavlov. Cond. response bias	12.0	16.3	28.5	5.3	-2.0
Time in closed arm before self-admin	0.9	1.0	1.7	0.5	1.3
Time in closed arm after self-admin	1.1	1.1	1.3	-1.0	1.1
Time in open arm before self-admin	1.2	1.3	2.6	-1.6	-0.0
Time in open arm after self-admin	1.3	1.5	2.3	0.8	-1.5
Bone: periosteal estimation	1.8	3.7	4.0	1.8	-2.0
Bone: periosteal perimeter	1.9	3.2	3.6	1.9	-1.7
Bone: post-yield work	0.3	0.4	0.7	0.8	-0.2
Progressive ratio test 1 active lever presses	0.2	0.2	0.2	-0.5	0.5
Progressive ratio test 1 breakpoint	0.2	0.2	0.2	-0.5	0.3
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.1	0.3	-0.1
Progressive ratio test 2 active lever presses	1.2	1.3	2.4	1.6	-0.5
Progressive ratio test 2 breakpoint	1.0	1.1	1.8	1.4	-0.6
Progressive ratio test 2 inactive lever presses	0.7	0.8	1.6	1.3	0.0
Incentive Sensitization - Responses	3.0	3.0	5.0	2.2	-1.0
Incentive Sensitization - Breakpoint	2.6	2.6	4.6	2.1	-0.8
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.0	-0.2
Progressive ratio	0.3	0.3	0.6	-0.3	0.8
Food seeking constrained by brief footshock	1.3	1.6	1.8	1.2	-1.3
Seeking ratio, punishment vs. effort	2.1	2.6	3.4	1.3	-1.8
Retroperitoneal fat weight	2.0	6.6	11.2	-1.4	-3.3
Reaction time number correct	0.7	1.0	1.9	-0.4	1.4
Reaction time mean minus median	1.1	1.5	2.0	1.4	-1.0
Reaction time mean minus median AUC	0.7	1.0	1.7	1.3	-0.5
Reaction time num false alarms	0.9	1.2	2.3	-1.5	-0.3
Reaction time num false alarms AUC	0.6	0.8	1.5	-1.2	-0.1
Reaction time trials correct on left	0.7	1.0	1.9	-0.4	1.4
Reaction time trials on left	0.7	1.0	1.9	-0.4	1.4
Reaction time mean	0.3	0.4	0.5	-0.5	-0.7
Reaction time mean AUC	0.4	0.5	0.9	-0.9	-0.4
Median of all reaction times	0.5	0.7	1.2	-1.1	-0.4
Reaction time omissions	0.1	0.2	0.2	-0.5	-0.4
Reaction time false alarm rate	0.6	0.8	1.3	-1.1	-0.6
Reaction time premature initiation rate	4.2	5.6	6.2	2.2	-2.5
Reaction time premature initiations	1.9	2.7	3.5	1.9	-1.4
Std. dev. reaction times	1.1	1.5	2.2	0.9	-1.5
Reaction time trials completed	0.7	1.0	1.9	-0.4	1.4
Reaction time trials AUC	0.5	0.7	1.4	-0.3	1.2
Run reversals in cocaine runway, females	3.1	3.0	5.8	0.5	-2.4
Run reversals in cocaine runway, males	0.0	0.0	0.0	0.2	0.2
Latency to leave start box in cocaine runway	1.5	1.6	3.2	-1.8	0.1
Latency to leave start box in cocaine runway, F	0.9	1.0	1.6	-1.3	-0.6
Latency to leave start box in cocaine runway, M	0.9	0.8	0.9	-0.9	1.0
Std. dev. time between licks in bursts	3.2	3.8	4.9	1.7	-2.2
Total sessions with >9 infusions	0.7	0.8	1.6	1.3	0.1
Short access day 1 total inactive lever presses	0.2	0.2	0.3	-0.5	0.3
Short access day 10 total inactive lever presses	0.1	0.1	0.2	0.4	0.4
Short access day 1 total infusions	0.7	0.7	1.0	1.0	-0.7
Short access day 10 total infusions	0.5	0.6	0.7	0.7	-0.8
Short access total infusions	0.4	0.4	0.5	0.5	-0.7
Short access day 1 locomotion	0.5	0.5	1.1	0.1	1.0
Short access day 10 total locomotion	0.0	0.0	0.1	-0.1	-0.3
Short access total locomotion	0.1	0.1	0.3	-0.5	0.2
One hour access (0.3 mA shock)	1.0	1.1	2.2	1.5	-0.3
Compulsive drug intake	0.4	0.4	0.7	0.1	0.9
One hour access (shock baseline)	0.6	0.7	1.2	1.1	-0.4
Social response proportion	0.3	0.3	0.4	-0.6	-0.5
Social responses	0.6	0.8	1.5	-0.2	-1.2
Social time	3.0	3.9	6.3	-2.5	1.3
Soleus weight	1.1	3.3	6.2	0.5	-2.5
Bone: stiffness	0.1	0.2	0.4	0.0	-0.6
Tibialis anterior weight	0.3	1.1	1.6	0.8	-1.3
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.2	-0.5	-0.3
Time to tail flick, vehicle, after self-admin	0.7	0.8	1.5	1.2	0.2
Time to tail flick, test, before self-admin	0.6	0.6	1.0	0.4	-1.0
Time to tail flick, test, after self-admin	1.0	1.1	1.6	0.8	-1.2
Delta time to tail flick, vehicle, before/after SA	1.0	1.0	1.5	1.2	0.8
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	-0.3	0.3
Tibia length	0.5	1.4	2.1	1.4	0.9
Ambulatory time before self-admin	0.8	0.8	1.2	-1.1	0.6
Ambulatory time after self-admin	2.8	3.0	3.6	-1.6	1.9
Bone: tissue strength	1.8	1.8	3.0	-0.7	1.7
Total heroin consumption	0.1	0.2	0.2	0.5	-0.3
Bone: trabecular number	1.0	1.5	1.6	-1.3	1.2
Bone: trabecular spacing	0.4	0.5	0.9	1.0	0.0
Bone: trabecular thickness	0.2	0.2	0.3	-0.3	-0.6
Bone: trabecular tissue density	0.7	1.0	1.8	-0.4	-1.3
Water consumed over 24 hours	0.6	0.7	1.0	-1.0	0.6
Number of responses in last shaping day	0.7	0.7	1.3	0.3	-1.2