LOC102552718

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	gene expression	LOC102552718	0.54	0.12	5.9e-07	0.14	0.15	0.15	0.13	3.6e-04	2.1e-04	2.5e-04	4.8e-04
2	Liver	intron excision ratio	chr9_112463041_112463383	0.11	0.05	4.6e-14	0.12	0.13	0.15	0.13	2.7e-13	2.3e-14	1.3e-16	5.3e-14
3	Liver	intron excision ratio	chr9_112463468_112474026	0.12	0.06	1.8e-14	0.12	0.13	0.18	0.14	2.3e-13	7.5e-14	5.0e-20	5.9e-15
4	Liver	gene expression	LOC102552718	0.58	0.11	0.0e+00	0.39	0.42	0.43	0.43	9.6e-46	5.9e-51	5.5e-52	1.3e-51
5	Liver	isoform ratio	XR_357275.5	0.05	0.03	1.3e-04	0.02	0.04	0.04	0.03	6.6e-03	2.7e-05	8.8e-05	4.6e-04
6	Liver	isoform ratio	XR_005489378.2	0.06	0.03	2.3e-05	0.02	0.05	0.04	0.04	1.9e-03	6.4e-06	2.6e-05	6.9e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.8	1.4	6.3	-2.5	0.8	1.2	-0.1	-0.3	0.3
Area under the delay curve	0.6	0.7	1.3	0.1	-0.8	-0.7	-0.5	1.1	-1.1
BMI with tail	0.8	2.8	10.5	3.2	-1.5	-1.6	0.4	0.8	-0.7
BMI without tail	0.6	1.9	8.5	2.9	-0.4	-0.5	1.4	0.4	-0.4
Body weight	1.4	6.0	22.0	4.7	-2.5	-2.6	0.1	0.6	-0.6
Weight adjusted by age	0.1	0.1	0.3	-0.4	-0.3	-0.0	-0.2	0.5	-0.5
Bone surface	0.8	1.4	6.7	-2.6	0.1	0.7	-0.7	-0.6	0.6
Bone volume	0.7	1.3	6.0	-2.5	0.7	1.1	-0.3	-0.4	0.4
Breakpoint value in progressive ratio session	0.6	0.7	1.6	1.0	0.0	-0.4	-0.4	-1.3	1.2
Number of licking bursts	0.2	0.3	0.9	1.0	0.1	0.3	0.6	-0.5	0.6
Context. condit. distance diff. score	0.2	0.2	0.6	-0.0	0.6	0.6	0.7	-0.2	0.2
Locomotion velocity, session 1	0.2	0.2	0.6	0.4	0.1	0.4	0.2	-0.7	0.8
Locomotion distance, session 1	1.1	1.4	3.6	0.6	-1.9	-1.6	-1.3	-0.2	0.2
Locomotion velocity, session 2	0.3	0.3	0.5	-0.3	-0.7	-0.5	-0.6	0.6	-0.6
Locomotion distance, session 2	0.8	1.1	2.2	0.1	-1.5	-1.4	-1.3	0.5	-0.6
Locomotion velocity, session 3	1.4	1.6	3.2	1.6	0.1	0.4	0.5	-1.8	1.8
Locomotion distance, session 3	1.6	1.7	5.1	2.3	0.3	0.3	0.9	-1.4	1.5
Stereotopy head waving bouts, day 3	0.5	0.6	1.3	-1.0	1.0	1.1	0.4	-0.2	0.2
Stereotopy head waving duration, day 3	1.5	1.8	3.5	-1.5	1.6	1.9	0.8	-1.1	1.1
Locomotion velocity, session 7	0.3	0.3	1.0	1.0	0.5	0.2	0.8	0.3	-0.3
Locomotion distance, session 7	0.6	0.7	2.2	1.5	0.2	-0.3	0.7	0.9	-0.9
Stereotopy head waving bouts, day 7	0.1	0.1	0.1	0.0	0.3	0.4	0.3	-0.2	0.2
Stereotopy head waving duration, day 7	0.4	0.5	1.2	0.1	0.4	0.7	0.4	-1.1	1.1
Locomotion velocity, session 8	0.2	0.3	0.6	-0.8	-0.1	-0.1	-0.4	0.6	-0.6
Locomotion distance, session 8	0.1	0.1	0.3	0.5	-0.1	-0.1	0.1	-0.5	0.4
Degree of sensitization distance	2.0	2.1	5.6	-1.0	-0.0	-0.5	-0.3	2.4	-2.4
Degree of sensitization stereotypy	0.1	0.1	0.6	0.8	-0.0	0.0	0.2	-0.2	0.2
Conditioned locomotion	0.7	0.8	1.9	1.4	0.6	0.1	0.7	1.0	-1.0
Cocaine response after cond. corrected	1.4	1.7	3.4	1.3	-1.7	-1.8	-0.8	0.9	-0.9
Cocaine response after cond. not corrected	2.2	2.5	4.6	1.9	-1.9	-2.1	-0.7	1.2	-1.2
Cocaine response before conditioning	0.4	0.5	1.4	1.2	0.3	0.1	0.9	0.6	-0.6
Saline control response	0.5	0.7	1.5	-0.7	1.2	1.2	0.7	-0.5	0.5
Bone: connectivity density	1.2	1.9	10.0	-3.2	0.4	0.9	-0.7	-0.3	0.3
Bone: cortical apparent density	0.5	0.7	1.1	1.0	-0.7	-0.9	-0.3	0.8	-0.9
Bone: cortical area	0.4	0.5	2.2	1.5	-0.6	-0.7	0.2	0.4	-0.3
Bone: cortical porosity	0.5	0.6	1.3	-0.3	0.6	0.5	0.5	1.1	-1.1
Bone: cortical porosity	0.6	0.6	1.9	0.1	0.2	-0.0	0.2	1.4	-1.3
Bone: cortical thickness	0.8	1.3	6.1	2.5	-0.1	-0.3	1.0	0.6	-0.5
Bone: cortical thickness	1.2	1.4	6.6	2.6	-0.0	-0.2	1.2	0.0	-0.0
Bone: cortical tissue density	0.5	0.7	1.0	1.0	-0.8	-1.0	-0.4	0.9	-0.9
Condit. Reinf. active minus inactive responses	0.8	0.9	3.0	1.7	-1.1	-1.2	-0.4	-0.1	0.0
Condit. Reinf. active-inactive response ratio	1.1	1.1	2.4	0.9	-1.5	-1.6	-0.9	0.4	-0.5
Condit. Reinf. active responses	0.8	1.0	2.2	1.5	-1.1	-1.3	-0.4	0.5	-0.5
Condit. Reinf. inactive responses	0.2	0.2	0.3	-0.3	-0.3	-0.5	-0.4	0.6	-0.6
Incentive salience index mean	0.7	0.9	1.8	1.3	-1.3	-1.3	-0.7	0.1	-0.1
Condit. Reinf. lever presses	0.4	0.6	1.1	-0.4	-1.0	-1.0	-1.0	0.3	-0.3
Condit. Reinf. active minus inactive responses	0.5	0.6	1.3	1.0	0.8	0.7	1.1	0.3	-0.3
Condit. Reinf. active-inactive response ratio	1.1	1.3	1.6	1.1	-1.3	-1.3	-0.7	1.2	-1.2
Condit. Reinf. active responses	2.3	3.3	6.9	0.7	2.6	2.3	2.5	-0.4	0.5
Condit. Reinf. inactive responses	5.7	7.3	15.4	-0.4	3.9	3.7	3.2	-1.5	1.5
Condit. Reinf. lever presses	1.8	2.5	3.6	0.6	1.6	1.6	1.5	-1.9	1.9
Condit. Reinf. lever reinforcers received	2.7	3.7	8.1	0.7	2.8	2.5	2.6	-0.5	0.6
Conditioned reinforcement - actives	0.4	0.7	1.1	1.1	0.9	0.9	1.0	-0.5	0.6
Conditioned reinforcement - inactives	0.7	1.1	4.4	2.1	-0.8	-1.0	0.4	0.2	-0.2
Conditioned locomotion	0.2	0.3	0.5	-0.5	0.7	0.5	0.4	-0.5	0.5
Patch foraging indifference point 0 sec	0.2	0.4	2.1	-1.4	-0.0	0.1	-0.4	0.2	-0.2
Patch foraging indifference point AUC	0.3	0.4	1.2	-0.2	-0.9	-0.7	-1.1	-0.1	0.1
Delay disc. indifference point, 0s delay	0.3	0.3	0.6	-0.2	-0.4	0.1	-0.6	-0.8	0.8
Delay disc. indifference point, 16s delay	0.3	0.3	0.5	0.1	-0.6	-0.7	-0.3	0.7	-0.7
Delay disc. indifference point, 2s delay	0.2	0.2	0.5	0.2	-0.7	-0.5	-0.7	0.2	-0.2
Delay disc. indifference point, 24s delay	0.9	1.0	1.9	-1.3	1.1	1.4	0.8	-0.6	0.6
Delay disc. indifference point, 4s delay	0.9	1.0	1.8	-0.1	-1.3	-0.9	-0.8	1.2	-1.2
Delay disc. indifference point, 8s delay	0.2	0.3	0.7	0.4	-0.2	-0.3	-0.0	0.8	-0.8
Indifference point function ln k	1.0	1.8	3.5	-0.2	1.8	1.9	1.7	-0.7	0.7
Indifference point function log k	1.0	1.8	3.5	-0.2	1.8	1.9	1.7	-0.7	0.7
Patch foraging total patch changes 0 sec	0.2	0.4	2.0	-1.4	0.1	0.2	-0.3	0.1	-0.1
Patch foraging total patch changes 12 sec	0.9	1.2	2.8	-1.3	-1.2	-1.1	-1.7	0.3	-0.3
Patch foraging total patch changes 18 sec	1.6	2.4	5.8	-1.8	-1.6	-1.7	-2.4	0.2	-0.2
Patch foraging total patch changes 24 sec	1.4	2.4	3.3	-1.3	-1.6	-1.7	-1.8	1.4	-1.4
Patch foraging total patch changes 6 sec	0.5	0.8	2.5	-1.6	-0.8	-0.3	-1.2	-0.2	0.1
Patch foraging time to switch 0 sec	0.3	0.6	1.1	-0.0	-0.6	-0.8	-0.5	1.0	-1.0
Patch foraging water rate 0 sec	0.1	0.1	0.3	0.5	-0.5	-0.4	0.0	-0.0	0.0
Patch foraging water rate 12 sec	0.0	0.1	0.4	-0.0	0.1	0.0	0.6	0.2	-0.2
Patch foraging water rate 18 sec	0.6	1.0	2.4	-0.1	-1.6	-1.5	-0.9	0.4	-0.4
Patch foraging water rate 24 sec	0.1	0.1	0.3	-0.1	-0.3	-0.5	-0.0	0.3	-0.3
Patch foraging water rate 6 sec	0.3	0.4	1.1	-0.2	0.1	-0.1	0.3	1.0	-1.0
Seeking ratio, delayed vs. immediate footshock	1.6	1.9	3.2	0.5	1.8	1.7	1.7	-1.1	1.1
Distance traveled before self-admin	0.5	0.6	1.4	-0.7	-1.2	-1.0	-0.7	0.4	-0.4
Distance traveled after self-admin	0.3	0.4	0.7	-0.0	-0.7	-0.9	-0.3	0.6	-0.7
Extensor digitorum longus weight	0.7	2.6	3.5	-1.1	-1.9	-1.9	-1.7	1.5	-1.5
Bone: elastic displacement	0.7	0.8	2.2	1.5	0.7	0.4	1.3	-0.0	0.1
Bone: elastic work	0.1	0.2	0.9	0.9	0.1	-0.1	0.3	0.1	-0.1
Bone: endosteal estimation	0.2	0.5	1.7	-1.3	0.1	0.3	-0.5	-0.7	0.7
Bone: endosteal perimeter	0.2	0.5	1.8	-1.3	-0.5	-0.3	-0.9	-0.1	0.1
Epididymis fat weight	0.9	3.1	6.3	1.0	-2.3	-2.5	-1.4	1.4	-1.4
Delta time in closed arm before/after self-admin	1.0	1.0	2.0	-0.3	-0.9	-0.7	-0.8	1.4	-1.4
Delta time in open arm before/after self-admin	0.2	0.2	0.5	0.5	-0.7	-0.6	0.1	0.2	-0.2
Diff in mean of infusions in LGA sessions	0.4	0.5	1.0	-0.4	0.7	0.7	-0.1	-1.0	1.0
Delay discount exponential model param	0.6	0.7	1.4	-0.0	0.8	0.7	0.5	-1.2	1.2
Extinction: sum of active levers before priming	1.0	1.2	2.4	0.4	-1.5	-1.5	-1.3	-0.6	0.5
Active lever presses in extinction session 6	0.5	0.5	1.8	1.3	-0.7	-0.7	-0.3	-0.1	0.1
Bone: final force	0.3	0.5	0.9	1.0	-0.4	-0.2	-0.1	-0.9	0.9
Bone: final moment	0.3	0.5	1.0	0.9	-0.3	-0.1	-0.0	-1.0	1.0
Food consumed during 24 hour testing period	0.5	0.6	1.2	1.1	-0.4	-0.3	-0.2	-1.1	1.1
Glucose	0.2	0.4	0.6	0.5	0.7	0.7	0.8	-0.5	0.6
Heart weight	0.7	1.0	1.4	1.2	-1.2	-1.1	-0.5	1.0	-0.9
Delay discount hyperbolic model param	0.7	0.7	1.4	-0.1	0.8	0.7	0.5	-1.2	1.2
Intermittent access intake day 1-15 change	0.1	0.3	1.5	-1.2	0.3	-0.0	-0.3	-0.2	0.1
Intermittent access intake escalation	0.1	0.3	1.6	-1.3	0.1	-0.1	-0.4	-0.0	-0.0
Intermittent access intake escalation 2	1.3	1.5	2.3	-1.1	-1.5	-1.5	-1.5	0.6	-0.7
Intermitt. access day 1 inactive lever presses	0.1	0.3	0.5	0.4	0.3	0.7	0.6	-0.6	0.6
Intermitt. access day 15 inactive lever presses	0.5	1.1	3.1	-0.0	-0.2	-0.7	0.0	1.7	-1.8
Intermitt. access escalation Index	0.3	0.4	0.7	-0.7	-0.8	-0.6	-0.7	-0.3	0.3
Intermittent access day 1 total infusions	0.2	0.3	1.2	1.1	0.5	0.1	0.7	0.1	-0.1
Intermittent access day 15 total infusions	0.1	0.1	0.2	0.1	0.3	-0.1	0.3	0.4	-0.4
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.1	0.2	0.4	-0.1	0.3	0.3	-0.3
Intermittent access total infusions	0.2	0.2	0.7	0.8	0.2	-0.2	0.5	0.4	-0.3
Intermittent access day 1 locomotion	0.7	0.9	3.5	1.9	0.5	0.3	1.2	-0.2	0.2
Intermittent access day 15 total locomotion	0.6	1.1	1.8	1.1	1.2	0.9	1.3	-0.8	0.8
Intermittent access total locomotion	0.3	0.4	1.1	1.0	0.6	0.3	0.8	-0.2	0.3
Intermittent access standard deviation	0.2	0.4	1.6	1.3	-0.2	-0.2	0.8	-0.4	0.4
Left kidney weight	1.1	5.2	18.5	4.3	-2.0	-2.4	0.2	1.3	-1.2
Right kidney weight	1.5	6.8	27.4	5.2	-2.5	-2.6	0.5	0.4	-0.4
Cocaine induced anxiety	0.4	0.5	0.9	0.3	-0.9	-0.9	-0.5	0.7	-0.7
Post-drug Anxiety	0.8	0.9	2.1	-0.0	-1.3	-1.4	-0.9	0.5	-0.5
Baseline Anxiety	0.3	0.4	0.9	-0.5	-0.0	-0.2	-0.5	-0.9	0.9
Tail length	0.5	1.9	4.1	2.0	-1.8	-1.9	-0.5	0.3	-0.3
Length with tail	0.5	2.2	6.4	2.5	-1.8	-1.8	-0.4	-0.3	0.3
Length without tail	0.9	2.8	5.6	2.3	-2.4	-2.2	-1.1	0.0	-0.0
Times rat made contact with spout	0.5	0.6	1.0	0.6	0.7	0.8	0.6	-1.0	1.0
Lifetime Intake	0.2	0.3	0.8	0.9	0.4	0.1	0.8	0.2	-0.1
Liver weight, left	0.3	0.5	1.2	1.1	-0.7	-0.9	-0.2	0.6	-0.6
Liver weight, right	0.3	0.5	1.4	1.2	-0.0	-0.5	0.4	0.7	-0.7
Locomotor activity	0.4	0.7	1.4	0.5	1.0	1.1	1.2	-0.3	0.3
Locomotor testing distance	0.8	1.4	3.1	-0.0	1.6	1.8	1.6	-0.5	0.5
Locomotor testing rearing	1.9	3.8	7.7	-0.1	2.6	2.8	2.4	-1.1	1.2
Locomotion in novel chamber	0.8	1.0	2.0	1.0	-0.6	-0.7	-0.4	-1.4	1.3
Locomotion in novel chamber post-restriction	1.2	2.0	5.6	1.0	-0.0	0.2	0.0	-2.4	2.3
Fecal boli incidents, locomotor time 1	0.9	1.4	3.2	-0.0	-1.8	-1.6	-1.5	0.2	-0.2
Change in fecal boli incidents, locomotor task	1.0	1.0	3.1	-0.6	1.8	1.2	1.0	0.0	-0.0
Time >=10cm from walls, locomotor time 1	0.7	0.7	0.9	-0.7	-0.9	-0.8	-1.0	0.8	-0.8
Bouts of movement, locomotor time 1	0.5	0.6	2.1	1.5	-0.0	0.2	0.8	0.6	-0.5
Total resting periods, locomotor time 1	0.5	0.6	2.4	1.5	-0.1	0.0	0.7	0.6	-0.5
Rest time, locomotor task time 1	0.3	0.4	0.8	0.9	-0.1	-0.4	0.1	0.9	-0.8
Distance moved, locomotor task time 1	0.2	0.3	1.6	-1.3	-0.1	0.1	-0.2	-0.1	0.1
Vertical activity count, locomotor time 1	0.3	0.7	1.7	-0.3	0.3	0.8	0.2	-1.3	1.3
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.4	-0.6	-0.1	-0.2	-0.3	0.0	-0.1
Bouts of movement, locomotor time 2	0.4	0.7	1.7	0.3	0.8	1.3	0.7	-0.7	0.7
Total resting periods, locomotor time 2	0.5	0.8	1.4	1.0	0.6	1.2	0.8	-0.8	0.9
Rest time, locomotor task time 2	0.8	1.1	1.4	1.1	-1.1	-1.0	-0.3	1.2	-1.2
Distance moved, locomotor task time 2	1.2	1.4	1.9	-0.6	1.4	1.2	1.0	-1.4	1.3
Vertical activity count, locomotor time 2	0.5	0.7	1.4	-0.4	0.8	0.6	-0.1	-1.2	1.2
Light reinforcement 1	0.6	1.5	2.3	-0.8	0.9	1.5	0.8	-1.5	1.5
Light reinforcement 2	0.5	0.8	1.9	-0.0	0.3	0.8	0.5	-1.4	1.4
Bone: marrow area	0.2	0.5	1.8	-1.4	-0.0	0.2	-0.6	-0.7	0.7
Bone: maximum diameter	0.5	1.0	1.5	-0.3	-1.2	-1.2	-1.1	0.9	-0.9
Bone: maximum force	0.4	0.7	2.5	1.6	-0.9	-0.8	-0.2	-0.3	0.3
Bone: maximum moment	0.3	0.6	2.3	1.5	-0.7	-0.7	-0.1	-0.4	0.4
Mean time between licks in bursts	0.9	2.2	3.1	1.0	1.8	1.5	1.7	-1.4	1.4
Mean num. licks in bursts	0.1	0.1	0.3	-0.5	0.5	0.2	0.0	-0.1	0.0
Cd content in liver	1.0	1.1	2.6	1.6	0.4	0.4	1.0	-1.2	1.2
Co content in liver	1.6	1.9	4.6	2.2	0.6	0.6	1.5	-1.3	1.3
Cu content in liver	1.7	2.1	5.0	2.2	-0.5	-0.5	0.3	-1.9	1.8
Fe content in liver	0.6	0.7	1.8	-0.5	1.3	1.2	0.9	0.1	-0.1
K content in liver	0.1	0.1	0.3	0.5	-0.1	0.0	0.1	-0.5	0.5
Mg content in liver	0.4	0.4	1.0	1.0	0.5	0.5	0.7	-0.5	0.5
Mn content in liver	1.3	1.4	3.3	-0.0	1.8	1.7	1.1	-0.5	0.6
Na content in liver	3.1	3.3	6.1	0.7	1.5	1.7	1.4	-2.5	2.5
Rb content in liver	0.7	0.8	1.5	-0.4	-0.5	-0.6	-1.0	1.2	-1.2
Se content in liver	0.4	0.5	0.9	0.2	0.9	0.6	0.9	0.7	-0.7
Sr content in liver	0.5	0.4	0.7	-0.6	0.7	0.8	0.4	-0.5	0.6
Zn content in liver	0.2	0.2	0.6	0.1	-0.7	-0.7	-0.4	0.1	-0.2
Bone: minimum diameter	0.1	0.3	0.7	0.1	-0.3	-0.3	-0.3	0.8	-0.8
Time in familiar zone, hab. session 1	1.6	1.5	3.8	-1.2	0.3	0.5	-0.0	-1.9	1.9
Time in novel zone, hab. session 1	0.6	0.6	1.4	0.8	-0.5	-0.5	-0.0	1.2	-1.1
Total zone transitions, hab. session 1	0.0	0.0	0.0	-0.2	-0.2	-0.2	0.0	0.1	-0.2
Total locomotion distance, hab. session 1	0.6	0.8	2.3	1.5	-0.9	-1.0	0.0	0.5	-0.5
Locomotion velocity, hab. session 1	0.3	0.4	1.4	1.2	-0.6	-0.6	0.2	0.5	-0.5
Time in familiar zone, hab. session 2	0.3	0.3	1.5	-1.2	0.3	0.3	-0.2	-0.2	0.1
Time in novel zone, hab. session 2	0.2	0.2	0.3	0.5	-0.5	-0.3	-0.2	-0.5	0.5
Total zone transitions, hab. session 2	0.1	0.1	0.1	0.3	0.3	0.3	0.3	-0.2	0.3
Total locomotion distance, hab. session 2	0.2	0.2	0.9	1.0	-0.3	-0.4	0.3	0.1	-0.1
Locomotion velocity, hab. session 2	0.2	0.3	1.6	1.2	-0.1	-0.2	0.5	0.2	-0.2
Novel to familiar place preference ratio	0.1	0.1	0.2	0.3	-0.3	-0.3	0.0	0.4	-0.5
Novelty place preference	0.1	0.1	0.2	0.3	-0.2	-0.2	0.1	0.5	-0.4
Time in novel zone, NPP test	0.1	0.1	0.3	0.2	-0.2	-0.2	0.2	0.5	-0.5
Total zone transitions, NPP test	0.1	0.1	0.8	0.9	0.0	-0.1	0.3	0.0	-0.0
Total locomotion distance, NPP test	0.5	0.6	2.9	1.7	0.2	0.1	0.9	-0.2	0.3
Locomotion velocity, NPP test	0.4	0.5	2.6	1.6	0.1	-0.0	0.7	-0.1	0.1
Intraocular pressure	1.0	1.4	5.6	-2.4	0.3	0.2	-0.5	1.1	-1.1
Delta distance traveled before/after self-admin	0.8	0.9	1.8	1.1	1.2	0.9	1.3	-0.2	0.3
Delta ambulatory time before/after self-admin	0.8	1.0	1.9	1.0	1.3	1.0	1.4	-0.3	0.4
Parametrial fat weight	0.2	0.5	1.3	1.1	0.8	0.6	1.0	0.1	-0.0
Pavlov. Cond. lever latency	0.9	1.1	2.3	-0.3	1.5	1.5	1.1	-0.6	0.6
Pavlov. Cond. magazine entry latency	0.3	0.4	0.9	0.6	-0.1	0.1	0.3	-0.9	0.9
Pavlov. Cond. change in total contacts	0.9	1.0	2.5	0.8	-1.6	-1.3	-0.7	-0.5	0.5
Pavlov. Cond. index score	0.3	0.4	0.9	0.7	-1.0	-0.9	-0.4	-0.3	0.3
Pavlov. Cond. latency score	0.4	0.5	1.2	0.9	-1.1	-1.0	-0.5	-0.2	0.1
Pavlov. Cond. lever contacts	0.6	0.8	1.7	0.4	-1.3	-1.3	-0.8	0.4	-0.4
Pavlov. Cond. magazine entry number	0.3	0.3	0.9	-0.5	0.1	-0.0	-0.2	0.9	-0.9
Pavlov. Cond. intertrial magazine entries	0.2	0.2	1.0	1.0	-0.1	-0.4	0.1	0.4	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.4	1.1	0.4	-1.1	-1.0	-0.6	-0.2	0.1
Pavlov. Cond. response bias	0.2	0.2	0.4	0.1	-0.7	-0.5	-0.4	-0.5	0.5
Pavlov. Cond. lever latency	4.4	6.0	10.3	-1.8	-1.9	-2.0	-2.1	3.2	-3.2
Pavlov. Cond. magazine entry latency	1.5	1.8	4.2	0.5	-2.1	-1.8	-1.7	-0.4	0.3
Pavlov. Cond. change in total contacts	2.5	4.0	6.8	1.1	1.8	1.8	1.6	-2.6	2.6
Pavlov. Cond. index score	1.7	2.2	5.1	1.4	0.5	0.6	0.7	-2.3	2.2
Pavlov. Cond. latency score	1.7	2.3	5.6	1.4	0.2	0.4	0.5	-2.4	2.4
Pavlov. Cond. lever contacts	4.2	5.8	9.9	1.9	1.9	1.9	2.0	-3.1	3.1
Pavlov. Cond. magazine entry number	0.5	0.7	1.3	-0.5	1.1	0.9	1.0	0.6	-0.6
Pavlov. Cond. intertrial magazine entries	0.9	1.3	2.8	0.1	1.7	1.4	1.6	0.6	-0.5
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.2	5.3	1.4	0.4	0.5	0.6	-2.3	2.3
Pavlov. Cond. response bias	2.5	3.4	5.8	1.3	1.5	1.6	1.6	-2.4	2.4
Time in closed arm before self-admin	0.3	0.4	1.0	-0.7	-0.0	-0.1	-0.6	-1.0	0.9
Time in closed arm after self-admin	0.2	0.3	0.6	-0.1	-0.6	-0.6	-0.8	0.3	-0.4
Time in open arm before self-admin	0.7	0.8	1.8	-0.9	1.4	1.3	0.3	0.1	-0.0
Time in open arm after self-admin	0.3	0.3	0.9	0.9	-0.5	-0.4	0.2	0.5	-0.5
Bone: periosteal estimation	0.0	0.0	0.1	-0.0	-0.3	-0.2	-0.3	-0.2	0.2
Bone: periosteal perimeter	0.0	0.0	0.1	-0.3	-0.1	-0.0	-0.2	-0.2	0.2
Bone: post-yield work	0.2	0.3	0.9	-0.3	0.2	0.4	0.2	-0.9	0.9
Progressive ratio test 1 active lever presses	1.0	1.3	4.7	2.2	0.9	0.3	1.3	-0.4	0.4
Progressive ratio test 1 breakpoint	1.0	1.2	4.6	2.1	0.8	0.3	1.3	-0.3	0.4
Progressive ratio test 1 inactive lever presses	0.8	1.2	2.9	0.7	1.7	1.2	1.4	-0.4	0.5
Progressive ratio test 2 active lever presses	0.3	0.3	1.0	1.0	0.6	0.2	0.7	0.1	-0.0
Progressive ratio test 2 breakpoint	0.3	0.3	1.0	1.0	0.5	0.2	0.6	0.2	-0.1
Progressive ratio test 2 inactive lever presses	0.7	1.2	2.1	1.5	0.0	-0.6	0.6	1.5	-1.5
Incentive Sensitization - Responses	0.0	0.1	0.1	-0.2	0.3	0.4	0.2	0.1	-0.1
Incentive Sensitization - Breakpoint	0.1	0.1	0.1	-0.4	0.3	0.3	0.1	0.3	-0.3
Sum of active levers in priming session hrs 5-6	1.0	0.9	1.8	0.6	-0.5	-0.8	-0.9	-1.3	1.3
Progressive ratio	1.1	1.7	6.9	-2.6	0.6	0.2	-0.9	-1.1	1.0
Food seeking constrained by brief footshock	0.3	0.4	0.9	-0.4	0.4	0.3	0.1	-0.9	0.9
Seeking ratio, punishment vs. effort	0.4	0.5	2.3	1.5	-0.4	0.1	0.7	0.4	-0.4
Retroperitoneal fat weight	0.9	3.7	10.3	3.2	-2.2	-2.5	-0.7	0.4	-0.4
Reaction time number correct	1.0	1.9	2.8	-1.5	1.5	1.7	0.7	-1.4	1.4
Reaction time mean minus median	0.3	0.8	1.7	0.6	-1.2	-1.3	-1.1	-0.0	-0.0
Reaction time mean minus median AUC	0.3	0.7	1.4	0.2	-1.2	-1.2	-1.1	-0.3	0.2
Reaction time num false alarms	1.3	1.9	5.5	0.2	-2.4	-1.7	-1.7	-0.2	0.2
Reaction time num false alarms AUC	1.4	2.2	6.2	-0.0	-2.5	-1.9	-1.9	-0.1	0.0
Reaction time trials correct on left	1.0	1.9	2.8	-1.5	1.5	1.7	0.7	-1.4	1.4
Reaction time trials on left	1.0	1.8	2.6	-1.5	1.4	1.6	0.6	-1.4	1.4
Reaction time mean	0.5	0.8	2.0	0.3	-1.2	-1.4	-1.2	0.0	-0.1
Reaction time mean AUC	0.5	0.8	1.9	-0.3	-1.2	-1.3	-1.4	-0.3	0.2
Median of all reaction times	0.5	0.7	1.6	-0.0	-1.1	-1.2	-1.1	0.0	-0.1
Reaction time omissions	0.2	0.3	0.9	0.9	-0.3	-0.8	-0.3	-0.0	0.0
Reaction time false alarm rate	2.5	3.4	8.8	1.2	-3.0	-2.5	-1.8	0.7	-0.7
Reaction time premature initiation rate	0.3	0.4	0.9	0.1	0.9	0.8	1.0	0.3	-0.3
Reaction time premature initiations	0.6	1.0	2.0	-1.1	1.4	1.4	1.0	-0.2	0.2
Std. dev. reaction times	0.4	0.7	1.6	1.0	-0.9	-1.3	-0.7	-0.1	0.1
Reaction time trials completed	1.0	1.8	2.6	-1.5	1.4	1.6	0.6	-1.4	1.4
Reaction time trials AUC	0.8	1.4	2.1	-1.4	1.3	1.5	0.6	-1.1	1.1
Run reversals in cocaine runway, females	0.8	0.8	1.6	-0.3	0.9	0.5	0.7	1.3	-1.2
Run reversals in cocaine runway, males	1.1	1.1	1.4	-0.9	-1.0	-1.0	-1.1	1.1	-1.2
Latency to leave start box in cocaine runway	0.1	0.1	0.3	0.4	0.0	0.2	0.5	0.3	-0.3
Latency to leave start box in cocaine runway, F	0.2	0.3	0.7	-0.5	-0.9	-0.4	-0.6	0.2	-0.2
Latency to leave start box in cocaine runway, M	1.6	1.5	3.5	1.6	1.2	0.8	1.9	0.5	-0.5
Std. dev. time between licks in bursts	0.5	0.6	1.4	1.2	0.6	0.6	0.7	-0.7	0.8
Total sessions with >9 infusions	0.6	0.7	1.5	1.2	0.8	0.7	1.2	0.3	-0.2
Short access day 1 total inactive lever presses	0.6	0.9	2.3	1.5	0.8	0.6	1.3	0.0	0.0
Short access day 10 total inactive lever presses	0.2	0.4	0.9	0.3	0.4	0.7	0.9	0.7	-0.7
Short access day 1 total infusions	0.4	0.5	1.6	1.3	0.1	0.1	1.0	0.5	-0.4
Short access day 10 total infusions	0.2	0.3	0.6	-0.0	0.8	0.6	0.7	0.1	-0.1
Short access total infusions	0.4	0.5	1.2	0.5	0.8	0.5	1.1	0.5	-0.5
Short access day 1 locomotion	0.3	0.4	1.2	0.5	0.5	0.7	1.1	0.3	-0.2
Short access day 10 total locomotion	1.4	2.6	5.3	1.6	1.7	1.8	2.3	-0.9	1.0
Short access total locomotion	0.9	1.0	1.9	0.9	1.1	1.2	1.4	-0.6	0.7
One hour access (0.3 mA shock)	0.4	0.4	0.7	0.8	0.6	0.1	0.3	-0.8	0.8
Compulsive drug intake	0.3	0.3	0.8	-0.7	-0.4	-0.4	-0.9	-0.3	0.3
One hour access (shock baseline)	0.2	0.3	0.8	0.9	0.7	0.2	0.7	0.2	-0.1
Social response proportion	1.4	1.6	3.4	-0.6	-1.7	-1.6	-1.9	0.1	-0.1
Social responses	0.3	0.3	0.7	-0.4	-0.3	-0.0	-0.6	-0.8	0.8
Social time	1.7	2.3	4.1	1.0	1.3	1.3	1.2	-2.0	2.0
Soleus weight	0.3	0.8	1.9	0.5	-1.4	-1.1	-1.1	-0.5	0.4
Bone: stiffness	0.1	0.2	0.6	0.8	-0.5	-0.3	-0.1	-0.5	0.5
Tibialis anterior weight	1.3	4.3	8.1	0.0	-2.8	-2.7	-2.1	1.7	-1.7
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.8	-0.9	0.3	0.0	-0.5	-0.7	0.7
Time to tail flick, vehicle, after self-admin	0.0	0.1	0.2	0.2	0.4	0.0	-0.1	0.1	-0.1
Time to tail flick, test, before self-admin	0.2	0.2	0.5	0.0	0.5	0.7	0.4	-0.4	0.4
Time to tail flick, test, after self-admin	0.8	0.9	1.7	-0.1	1.3	1.2	0.9	-0.8	0.8
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.1	1.1	-0.2	-0.3	0.2	0.7	-0.6
Delta time to tail flick, test, before/after SA	0.0	0.0	0.2	-0.5	0.2	0.2	0.1	-0.0	0.0
Tibia length	0.8	2.3	5.2	2.3	-1.1	-1.5	0.1	1.6	-1.6
Ambulatory time before self-admin	0.3	0.5	0.8	-0.6	-0.9	-0.8	-0.7	0.4	-0.5
Ambulatory time after self-admin	0.4	0.4	0.8	0.9	-0.4	-0.8	0.1	0.7	-0.7
Bone: tissue strength	0.1	0.1	0.3	-0.5	0.1	0.2	-0.4	0.0	0.0
Total heroin consumption	0.3	0.4	1.0	0.2	0.6	-0.1	-0.1	-1.0	0.9
Bone: trabecular number	1.1	1.8	5.9	-2.4	1.1	1.5	0.3	-0.8	0.8
Bone: trabecular spacing	0.9	1.1	2.3	0.9	-1.2	-1.5	-0.9	0.9	-0.9
Bone: trabecular thickness	1.0	1.2	3.0	-0.5	1.6	1.7	1.0	-0.6	0.7
Bone: trabecular tissue density	0.5	0.7	3.3	1.8	-0.7	-0.7	-0.1	-0.3	0.4
Water consumed over 24 hours	0.2	0.3	0.6	-0.5	0.7	0.8	0.1	-0.4	0.4
Number of responses in last shaping day	0.2	0.2	0.4	0.7	-0.0	-0.4	0.1	0.6	-0.6