Hub : Genes

LOC102552420

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	intron excision ratio	chr7_8251234_8252522	0.04	0.03	4.9e-04	0.01	0.02	0.01	0.02	1.3e-02	3.2e-03	1.4e-02	1.1e-02
2	Brain	intron excision ratio	chr7_8251643_8252522	0.04	0.03	7.6e-04	0.01	0.02	0.01	0.01	1.9e-02	4.7e-03	1.7e-02	1.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.1	0.1	0.1	0.4	-0.4
Area under the delay curve	2.0	2.1	2.1	-1.4	1.4
BMI with tail	6.9	22.5	22.5	-4.7	4.7
BMI without tail	2.6	5.4	5.4	-2.3	2.3
Body weight	1.3	5.5	5.5	-2.3	2.3
Weight adjusted by age	0.4	0.4	0.4	-0.7	0.7
Bone surface	0.7	1.2	1.2	1.1	-1.1
Bone volume	0.7	1.2	1.2	1.1	-1.1
Breakpoint value in progressive ratio session	5.2	5.7	5.7	2.4	-2.4
Number of licking bursts	0.1	0.2	0.2	-0.4	0.4
Context. condit. distance diff. score	0.4	0.4	0.4	-0.7	0.7
Locomotion velocity, session 1	0.9	1.0	1.0	1.0	-1.0
Locomotion distance, session 1	0.2	0.3	0.3	0.5	-0.5
Locomotion velocity, session 2	4.4	5.1	5.2	2.3	-2.3
Locomotion distance, session 2	2.0	2.8	2.8	1.7	-1.7
Locomotion velocity, session 3	6.4	7.5	7.5	2.7	-2.7
Locomotion distance, session 3	0.0	0.0	0.0	0.1	-0.1
Stereotopy head waving bouts, day 3	5.3	6.2	6.2	2.5	-2.5
Stereotopy head waving duration, day 3	6.0	7.2	7.2	2.7	-2.7
Locomotion velocity, session 7	0.9	1.0	1.0	1.0	-1.0
Locomotion distance, session 7	0.1	0.1	0.1	-0.3	0.3
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	0.2	-0.2
Stereotopy head waving duration, day 7	0.3	0.4	0.4	0.6	-0.6
Locomotion velocity, session 8	0.7	0.8	0.8	0.9	-0.9
Locomotion distance, session 8	0.1	0.2	0.2	0.4	-0.4
Degree of sensitization distance	0.4	0.4	0.4	-0.6	0.6
Degree of sensitization stereotypy	1.5	1.6	1.6	-1.3	1.3
Conditioned locomotion	2.3	2.6	2.6	-1.6	1.6
Cocaine response after cond. corrected	6.2	6.9	6.9	-2.6	2.6
Cocaine response after cond. not corrected	6.8	7.4	7.5	-2.7	2.7
Cocaine response before conditioning	0.6	0.7	0.7	0.8	-0.8
Saline control response	0.1	0.1	0.1	-0.3	0.3
Bone: connectivity density	0.0	0.0	0.0	-0.1	0.1
Bone: cortical apparent density	1.2	1.5	1.5	-1.2	1.2
Bone: cortical area	0.3	0.5	0.5	-0.7	0.7
Bone: cortical porosity	0.7	0.7	0.7	0.9	-0.9
Bone: cortical porosity	0.1	0.1	0.1	0.3	-0.3
Bone: cortical thickness	1.0	1.7	1.7	-1.3	1.3
Bone: cortical thickness	0.0	0.0	0.0	-0.0	0.0
Bone: cortical tissue density	0.8	1.1	1.1	-1.0	1.0
Condit. Reinf. active minus inactive responses	4.5	5.0	5.0	2.2	-2.2
Condit. Reinf. active-inactive response ratio	2.0	2.2	2.2	1.5	-1.5
Condit. Reinf. active responses	4.2	5.2	5.2	2.3	-2.3
Condit. Reinf. inactive responses	1.1	1.3	1.3	1.1	-1.1
Incentive salience index mean	2.6	3.2	3.2	1.8	-1.8
Condit. Reinf. lever presses	0.1	0.2	0.2	0.4	-0.4
Condit. Reinf. active minus inactive responses	2.1	2.6	2.6	1.6	-1.6
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.1	-0.1
Condit. Reinf. active responses	2.5	3.4	3.4	1.9	-1.9
Condit. Reinf. inactive responses	1.6	2.0	2.0	1.4	-1.4
Condit. Reinf. lever presses	2.3	3.1	3.1	1.8	-1.8
Condit. Reinf. lever reinforcers received	1.8	2.5	2.5	1.6	-1.6
Conditioned reinforcement - actives	3.0	3.0	3.0	1.7	-1.7
Conditioned reinforcement - inactives	0.9	1.0	1.0	-1.0	1.0
Conditioned locomotion	8.7	10.5	10.5	3.2	-3.2
Patch foraging indifference point 0 sec	0.2	0.3	0.3	-0.5	0.5
Patch foraging indifference point AUC	1.1	1.3	1.3	1.1	-1.1
Delay disc. indifference point, 0s delay	6.1	6.7	6.7	-2.6	2.6
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	-0.3	0.3
Delay disc. indifference point, 2s delay	5.4	5.9	6.0	-2.4	2.4
Delay disc. indifference point, 24s delay	0.5	0.5	0.5	-0.7	0.7
Delay disc. indifference point, 4s delay	0.7	0.8	0.8	-0.9	0.9
Delay disc. indifference point, 8s delay	1.2	1.3	1.3	-1.1	1.1
Indifference point function ln k	0.3	0.4	0.4	-0.6	0.6
Indifference point function log k	0.3	0.4	0.4	-0.6	0.6
Patch foraging total patch changes 0 sec	0.1	0.2	0.2	-0.5	0.5
Patch foraging total patch changes 12 sec	0.4	0.5	0.5	-0.7	0.7
Patch foraging total patch changes 18 sec	1.0	1.3	1.3	1.2	-1.2
Patch foraging total patch changes 24 sec	0.1	0.1	0.1	0.4	-0.4
Patch foraging total patch changes 6 sec	0.1	0.2	0.2	0.5	-0.5
Patch foraging time to switch 0 sec	1.3	2.0	2.0	-1.4	1.4
Patch foraging water rate 0 sec	0.0	0.0	0.0	0.0	-0.0
Patch foraging water rate 12 sec	1.3	1.9	1.9	-1.4	1.4
Patch foraging water rate 18 sec	0.0	0.0	0.0	-0.0	0.0
Patch foraging water rate 24 sec	0.7	0.9	1.0	-1.0	1.0
Patch foraging water rate 6 sec	0.2	0.3	0.3	0.5	-0.5
Seeking ratio, delayed vs. immediate footshock	5.8	6.7	6.7	2.6	-2.6
Distance traveled before self-admin	0.2	0.2	0.2	-0.4	0.4
Distance traveled after self-admin	1.1	1.2	1.2	1.1	-1.1
Extensor digitorum longus weight	5.2	20.5	20.5	-4.5	4.5
Bone: elastic displacement	0.3	0.4	0.4	0.6	-0.6
Bone: elastic work	0.1	0.1	0.1	-0.4	0.4
Bone: endosteal estimation	0.1	0.3	0.3	-0.5	0.5
Bone: endosteal perimeter	0.3	0.7	0.7	0.9	-0.8
Epididymis fat weight	0.1	0.2	0.2	0.5	-0.5
Delta time in closed arm before/after self-admin	1.0	0.9	0.9	-1.0	1.0
Delta time in open arm before/after self-admin	1.4	1.3	1.3	-1.2	1.2
Diff in mean of infusions in LGA sessions	1.6	1.8	1.8	1.3	-1.3
Delay discount exponential model param	1.8	1.9	1.9	1.4	-1.4
Extinction: sum of active levers before priming	0.9	0.9	0.9	1.0	-1.0
Active lever presses in extinction session 6	3.5	3.4	3.4	1.9	-1.9
Bone: final force	0.9	1.4	1.4	-1.2	1.2
Bone: final moment	0.7	1.1	1.1	-1.0	1.0
Food consumed during 24 hour testing period	0.5	0.6	0.6	-0.8	0.8
Glucose	1.3	1.9	1.9	-1.4	1.4
Heart weight	0.3	0.4	0.4	0.6	-0.6
Delay discount hyperbolic model param	2.6	2.7	2.7	1.7	-1.7
Intermittent access intake day 1-15 change	6.9	6.8	6.8	2.6	-2.6
Intermittent access intake escalation	5.7	5.6	5.6	2.4	-2.4
Intermittent access intake escalation 2	7.3	7.2	7.3	2.7	-2.7
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.3	0.6	-0.6
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.3	0.5	-0.5
Intermitt. access escalation Index	0.1	0.0	0.0	-0.2	0.2
Intermittent access day 1 total infusions	0.1	0.1	0.1	-0.3	0.3
Intermittent access day 15 total infusions	1.5	1.7	1.7	1.3	-1.3
Intermittent access terminal intake (last 3 days)	1.1	1.2	1.2	1.1	-1.1
Intermittent access total infusions	0.1	0.1	0.1	0.3	-0.3
Intermittent access day 1 locomotion	0.2	0.2	0.2	0.4	-0.4
Intermittent access day 15 total locomotion	3.2	3.5	3.5	1.9	-1.9
Intermittent access total locomotion	1.0	1.1	1.1	1.1	-1.1
Intermittent access standard deviation	3.1	3.3	3.3	1.8	-1.8
Left kidney weight	0.1	0.2	0.2	0.5	-0.5
Right kidney weight	1.7	4.7	4.7	2.2	-2.2
Cocaine induced anxiety	1.1	1.3	1.3	1.1	-1.1
Post-drug Anxiety	0.8	0.9	0.9	0.9	-0.9
Baseline Anxiety	0.0	0.0	0.0	0.0	-0.0
Tail length	3.1	9.3	9.4	3.1	-3.1
Length with tail	2.0	7.3	7.3	2.7	-2.7
Length without tail	0.1	0.2	0.2	0.4	-0.4
Times rat made contact with spout	0.2	0.3	0.3	-0.5	0.5
Lifetime Intake	0.0	0.0	0.0	0.2	-0.2
Liver weight, left	2.9	4.6	4.6	-2.1	2.1
Liver weight, right	1.8	3.0	3.0	-1.7	1.7
Locomotor activity	4.0	6.4	6.4	2.5	-2.5
Locomotor testing distance	2.3	3.8	3.8	2.0	-1.9
Locomotor testing rearing	0.0	0.0	0.0	0.1	-0.1
Locomotion in novel chamber	0.4	0.5	0.5	0.7	-0.7
Locomotion in novel chamber post-restriction	0.8	0.9	0.9	1.0	-1.0
Fecal boli incidents, locomotor time 1	2.4	2.6	2.6	-1.6	1.6
Change in fecal boli incidents, locomotor task	0.6	0.6	0.6	0.8	-0.7
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.2	-0.4	0.4
Bouts of movement, locomotor time 1	0.1	0.1	0.1	0.4	-0.4
Total resting periods, locomotor time 1	0.2	0.2	0.2	0.5	-0.5
Rest time, locomotor task time 1	0.2	0.2	0.2	0.5	-0.5
Distance moved, locomotor task time 1	0.2	0.2	0.2	-0.4	0.4
Vertical activity count, locomotor time 1	0.1	0.1	0.1	-0.2	0.2
Time >=10cm from walls, locomotor time 2	1.3	1.3	1.3	-1.2	1.2
Bouts of movement, locomotor time 2	0.5	0.6	0.6	0.8	-0.8
Total resting periods, locomotor time 2	0.5	0.5	0.5	0.7	-0.7
Rest time, locomotor task time 2	0.6	0.7	0.7	0.9	-0.9
Distance moved, locomotor task time 2	1.0	1.1	1.1	-1.1	1.1
Vertical activity count, locomotor time 2	1.1	1.2	1.2	-1.1	1.1
Light reinforcement 1	6.2	11.2	11.2	3.3	-3.4
Light reinforcement 2	1.8	2.4	2.4	1.6	-1.6
Bone: marrow area	0.1	0.3	0.3	-0.6	0.6
Bone: maximum diameter	0.9	1.6	1.6	1.3	-1.3
Bone: maximum force	1.0	1.8	1.8	-1.3	1.3
Bone: maximum moment	0.8	1.4	1.4	-1.2	1.2
Mean time between licks in bursts	3.9	5.4	5.4	2.3	-2.3
Mean num. licks in bursts	0.0	0.0	0.0	0.0	-0.0
Cd content in liver	0.2	0.2	0.2	-0.4	0.4
Co content in liver	0.5	0.6	0.6	0.8	-0.8
Cu content in liver	0.0	0.0	0.0	-0.1	0.1
Fe content in liver	0.0	0.0	0.0	-0.0	0.0
K content in liver	0.0	0.0	0.0	0.2	-0.2
Mg content in liver	0.1	0.1	0.1	0.3	-0.3
Mn content in liver	1.6	1.8	1.9	1.4	-1.4
Na content in liver	0.8	0.9	0.9	-0.9	0.9
Rb content in liver	0.1	0.2	0.2	-0.4	0.4
Se content in liver	0.2	0.3	0.3	0.5	-0.5
Sr content in liver	0.0	0.0	0.0	-0.1	0.1
Zn content in liver	1.5	1.6	1.6	1.3	-1.3
Bone: minimum diameter	0.0	0.0	0.0	0.1	-0.1
Time in familiar zone, hab. session 1	2.1	1.9	1.9	1.4	-1.4
Time in novel zone, hab. session 1	0.7	0.6	0.6	-0.8	0.8
Total zone transitions, hab. session 1	1.2	1.7	1.7	1.3	-1.3
Total locomotion distance, hab. session 1	1.6	2.2	2.2	1.5	-1.5
Locomotion velocity, hab. session 1	2.0	2.8	2.8	1.7	-1.7
Time in familiar zone, hab. session 2	6.0	6.2	6.2	2.5	-2.5
Time in novel zone, hab. session 2	4.1	4.1	4.1	-2.0	2.0
Total zone transitions, hab. session 2	0.0	0.0	0.0	-0.2	0.2
Total locomotion distance, hab. session 2	1.1	1.5	1.5	1.2	-1.2
Locomotion velocity, hab. session 2	1.1	1.5	1.5	1.2	-1.2
Novel to familiar place preference ratio	3.2	3.3	3.3	-1.8	1.8
Novelty place preference	1.7	1.8	1.8	-1.3	1.3
Time in novel zone, NPP test	2.1	2.2	2.2	-1.5	1.5
Total zone transitions, NPP test	0.0	0.0	0.0	0.0	-0.0
Total locomotion distance, NPP test	0.0	0.0	0.0	0.0	-0.0
Locomotion velocity, NPP test	0.1	0.1	0.1	0.3	-0.3
Intraocular pressure	0.0	0.0	0.0	-0.0	0.0
Delta distance traveled before/after self-admin	1.7	1.8	1.8	1.4	-1.4
Delta ambulatory time before/after self-admin	2.0	2.2	2.2	1.5	-1.5
Parametrial fat weight	0.4	0.8	0.8	0.9	-0.9
Pavlov. Cond. lever latency	0.0	0.0	0.0	-0.1	0.1
Pavlov. Cond. magazine entry latency	2.7	3.5	3.5	1.9	-1.9
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.3	-0.3
Pavlov. Cond. index score	0.5	0.6	0.6	0.8	-0.8
Pavlov. Cond. latency score	0.5	0.6	0.6	0.8	-0.8
Pavlov. Cond. lever contacts	0.1	0.2	0.2	0.4	-0.4
Pavlov. Cond. magazine entry number	0.6	0.8	0.8	-0.9	0.9
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	1.1	1.0	-1.0
Pavlov. Cond. response bias	1.1	1.3	1.3	1.2	-1.2
Pavlov. Cond. lever latency	1.0	1.4	1.4	-1.2	1.2
Pavlov. Cond. magazine entry latency	0.6	0.7	0.7	0.9	-0.9
Pavlov. Cond. change in total contacts	1.0	1.4	1.4	1.2	-1.2
Pavlov. Cond. index score	1.1	1.4	1.4	1.2	-1.2
Pavlov. Cond. latency score	1.1	1.3	1.3	1.2	-1.2
Pavlov. Cond. lever contacts	0.8	1.2	1.2	1.1	-1.1
Pavlov. Cond. magazine entry number	1.1	1.3	1.3	-1.2	1.2
Pavlov. Cond. intertrial magazine entries	0.6	0.7	0.7	-0.9	0.8
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	1.5	1.2	-1.2
Pavlov. Cond. response bias	2.0	2.7	2.7	1.7	-1.7
Time in closed arm before self-admin	0.6	0.7	0.7	-0.8	0.8
Time in closed arm after self-admin	0.0	0.0	0.0	0.1	-0.1
Time in open arm before self-admin	1.2	1.3	1.3	1.1	-1.1
Time in open arm after self-admin	0.9	0.9	0.9	-1.0	1.0
Bone: periosteal estimation	0.2	0.3	0.3	-0.6	0.6
Bone: periosteal perimeter	0.1	0.2	0.2	0.5	-0.5
Bone: post-yield work	0.7	1.0	1.0	-1.0	1.0
Progressive ratio test 1 active lever presses	0.2	0.2	0.2	-0.5	0.5
Progressive ratio test 1 breakpoint	0.3	0.3	0.3	-0.5	0.5
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	0.0	-0.0
Progressive ratio test 2 active lever presses	0.2	0.2	0.2	0.4	-0.4
Progressive ratio test 2 breakpoint	0.3	0.4	0.4	0.6	-0.6
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	0.3	-0.3
Incentive Sensitization - Responses	0.3	0.3	0.3	0.6	-0.6
Incentive Sensitization - Breakpoint	0.4	0.4	0.4	0.7	-0.7
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.1	0.1
Progressive ratio	0.2	0.2	0.2	-0.5	0.5
Food seeking constrained by brief footshock	0.1	0.1	0.1	0.4	-0.4
Seeking ratio, punishment vs. effort	0.1	0.1	0.1	0.4	-0.4
Retroperitoneal fat weight	0.6	1.9	1.9	-1.4	1.4
Reaction time number correct	0.7	1.0	1.0	-1.0	1.0
Reaction time mean minus median	0.9	1.2	1.2	1.1	-1.1
Reaction time mean minus median AUC	0.1	0.1	0.1	0.3	-0.3
Reaction time num false alarms	0.0	0.0	0.0	-0.2	0.2
Reaction time num false alarms AUC	0.1	0.2	0.2	-0.4	0.4
Reaction time trials correct on left	0.7	1.0	1.0	-1.0	1.0
Reaction time trials on left	0.7	1.0	1.0	-1.0	1.0
Reaction time mean	0.0	0.0	0.0	0.1	-0.1
Reaction time mean AUC	0.0	0.0	0.0	0.0	-0.0
Median of all reaction times	0.1	0.2	0.2	-0.4	0.4
Reaction time omissions	0.3	0.4	0.4	0.6	-0.6
Reaction time false alarm rate	0.0	0.0	0.0	-0.0	0.0
Reaction time premature initiation rate	0.7	1.0	1.0	1.0	-1.0
Reaction time premature initiations	0.2	0.3	0.3	0.5	-0.5
Std. dev. reaction times	0.3	0.5	0.5	0.7	-0.7
Reaction time trials completed	0.7	1.0	1.0	-1.0	1.0
Reaction time trials AUC	0.7	1.0	1.0	-1.0	1.0
Run reversals in cocaine runway, females	1.0	1.0	1.0	1.0	-1.0
Run reversals in cocaine runway, males	1.6	1.6	1.6	1.3	-1.3
Latency to leave start box in cocaine runway	1.3	1.4	1.5	1.2	-1.2
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	0.3	-0.3
Latency to leave start box in cocaine runway, M	2.5	2.4	2.4	1.6	-1.6
Std. dev. time between licks in bursts	1.1	1.3	1.3	1.1	-1.1
Total sessions with >9 infusions	0.0	0.0	0.0	0.2	-0.2
Short access day 1 total inactive lever presses	0.0	0.0	0.0	0.2	-0.2
Short access day 10 total inactive lever presses	0.0	0.0	0.0	0.1	-0.1
Short access day 1 total infusions	0.2	0.2	0.2	0.4	-0.4
Short access day 10 total infusions	0.0	0.0	0.0	0.0	-0.0
Short access total infusions	0.0	0.0	0.0	0.1	-0.1
Short access day 1 locomotion	0.9	0.9	0.9	1.0	-1.0
Short access day 10 total locomotion	4.0	4.4	4.4	2.1	-2.1
Short access total locomotion	1.0	1.0	1.0	1.0	-1.0
One hour access (0.3 mA shock)	0.3	0.3	0.3	-0.6	0.6
Compulsive drug intake	0.8	0.8	0.8	-0.9	0.9
One hour access (shock baseline)	0.0	0.0	0.0	0.0	-0.0
Social response proportion	0.7	0.8	0.8	0.9	-0.9
Social responses	8.9	11.4	11.4	3.4	-3.4
Social time	0.8	1.1	1.1	-1.0	1.0
Soleus weight	9.6	28.2	28.2	-5.3	5.3
Bone: stiffness	2.9	4.6	4.6	-2.1	2.1
Tibialis anterior weight	1.0	3.4	3.4	-1.8	1.8
Time to tail flick, vehicle, before self-admin	1.0	1.0	1.0	1.0	-1.0
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.1	-0.1
Time to tail flick, test, before self-admin	0.3	0.3	0.3	0.6	-0.6
Time to tail flick, test, after self-admin	0.3	0.3	0.3	0.5	-0.5
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	0.8	-0.9	0.9
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	0.2	-0.2
Tibia length	0.9	2.5	2.5	1.6	-1.6
Ambulatory time before self-admin	0.2	0.2	0.2	-0.4	0.4
Ambulatory time after self-admin	0.6	0.7	0.7	0.8	-0.8
Bone: tissue strength	1.9	1.8	1.8	-1.4	1.4
Total heroin consumption	2.2	2.6	2.6	1.6	-1.6
Bone: trabecular number	1.1	1.8	1.8	1.3	-1.3
Bone: trabecular spacing	0.8	1.0	1.1	-1.0	1.0
Bone: trabecular thickness	0.3	0.3	0.3	0.6	-0.6
Bone: trabecular tissue density	2.9	4.0	4.0	-2.0	2.0
Water consumed over 24 hours	0.3	0.4	0.4	-0.6	0.6
Number of responses in last shaping day	0.2	0.2	0.2	0.4	-0.4