Hub : Genes

LOC102550782

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	gene expression	LOC102550782	0.18	0.1	5.0e-03	0.06	0.06	0.03	0.03	1.4e-02	1.3e-02	8.4e-02	5.3e-02
2	BLA	gene expression	LOC102550782	0.11	0.06	5.0e-05	0.09	0.09	0.04	0.07	2.5e-05	2.7e-05	3.4e-03	1.1e-04
3	Brain	mRNA stability	LOC102550782	0.03	0.02	9.5e-03	0.01	0.01	0	0	1.3e-02	2.3e-02	3.6e-01	1.0e-01
4	PL	gene expression	LOC102550782	0.03	0.02	9.3e-04	0.01	0.02	0.01	0.01	4.8e-02	3.2e-03	1.9e-02	3.1e-02
5	Brain	gene expression	LOC102550782	0.09	0.06	1.9e-05	0.03	0.05	0.05	0.04	2.0e-03	1.2e-05	2.9e-05	6.9e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	3.9	6.6	9.0	-1.9	3.0	2.7	-2.7	-2.4
Area under the delay curve	0.1	0.1	0.4	-0.6	0.1	0.1	-0.3	-0.2
BMI with tail	4.7	15.2	22.0	2.8	-3.5	-3.5	4.6	4.7
BMI without tail	2.5	5.1	8.6	1.6	-2.0	-2.0	2.9	2.5
Body weight	3.1	13.1	24.3	1.6	-3.0	-3.0	4.6	4.9
Weight adjusted by age	3.2	3.7	6.1	1.3	-1.6	-1.6	2.3	2.5
Bone surface	7.2	12.7	15.1	-3.5	3.9	3.7	-3.5	-3.2
Bone volume	6.6	11.2	13.6	-3.4	3.7	3.4	-3.2	-3.0
Breakpoint value in progressive ratio session	2.1	2.3	2.6	1.5	-1.5	-1.6	1.6	1.3
Number of licking bursts	0.1	0.1	0.3	-0.5	0.2	0.2	0.1	0.4
Context. condit. distance diff. score	0.0	0.0	0.1	-0.2	-0.0	-0.0	0.1	0.2
Locomotion velocity, session 1	0.1	0.1	0.2	0.4	-0.5	-0.5	0.2	-0.1
Locomotion distance, session 1	0.2	0.2	0.5	0.7	-0.4	-0.7	0.3	-0.2
Locomotion velocity, session 2	0.3	0.3	0.9	0.7	-0.4	-0.3	-0.2	-1.0
Locomotion distance, session 2	0.4	0.5	1.4	1.2	-0.4	-0.7	0.2	-0.6
Locomotion velocity, session 3	2.8	3.3	5.4	2.3	-1.8	-1.9	1.8	1.0
Locomotion distance, session 3	0.2	0.2	0.3	-0.3	0.5	0.4	-0.3	-0.5
Stereotopy head waving bouts, day 3	1.4	1.7	3.8	2.0	-1.4	-1.5	0.4	-0.2
Stereotopy head waving duration, day 3	0.7	0.8	1.7	1.3	-1.0	-1.1	0.1	-0.5
Locomotion velocity, session 7	0.1	0.1	0.1	0.2	0.2	0.3	-0.2	-0.3
Locomotion distance, session 7	1.0	1.2	1.5	-1.2	1.2	1.2	-1.0	-0.9
Stereotopy head waving bouts, day 7	0.5	0.6	2.1	1.4	-0.4	-0.6	0.5	0.3
Stereotopy head waving duration, day 7	0.5	0.6	2.6	1.6	-0.5	-0.5	0.3	0.2
Locomotion velocity, session 8	0.1	0.1	0.2	-0.1	-0.0	-0.1	-0.2	-0.5
Locomotion distance, session 8	0.1	0.2	0.4	0.4	-0.2	-0.4	0.0	-0.6
Degree of sensitization distance	0.3	0.3	0.4	-0.6	0.3	0.4	-0.6	-0.7
Degree of sensitization stereotypy	0.6	0.6	1.7	1.3	-0.4	-0.4	0.7	0.7
Conditioned locomotion	0.3	0.3	0.7	-0.4	0.5	0.4	-0.7	-0.9
Cocaine response after cond. corrected	1.1	1.2	1.9	-1.4	1.2	1.1	-1.0	-0.6
Cocaine response after cond. not corrected	1.4	1.5	2.4	-1.6	1.4	1.3	-1.1	-0.6
Cocaine response before conditioning	0.0	0.0	0.1	0.1	-0.2	-0.0	-0.1	-0.3
Saline control response	3.9	5.1	7.0	2.0	-2.2	-2.3	2.6	2.2
Bone: connectivity density	3.7	5.8	7.6	-1.2	2.6	2.4	-2.7	-2.8
Bone: cortical apparent density	3.1	4.1	5.8	2.3	-2.3	-2.4	1.6	1.0
Bone: cortical area	0.1	0.1	0.3	-0.2	-0.2	-0.4	0.3	-0.5
Bone: cortical porosity	1.5	1.7	2.5	-1.6	1.4	1.4	-1.0	-1.0
Bone: cortical porosity	0.9	1.0	2.2	-1.5	1.1	1.0	-0.6	-0.6
Bone: cortical thickness	8.7	14.3	18.0	4.2	-4.0	-4.2	3.7	2.5
Bone: cortical thickness	2.8	3.2	6.0	2.4	-1.9	-2.0	1.4	0.6
Bone: cortical tissue density	3.0	3.9	5.4	2.3	-2.3	-2.3	1.6	1.1
Condit. Reinf. active minus inactive responses	0.5	0.6	1.9	-1.4	0.6	0.5	-0.4	-0.5
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.7	-1.3	0.6	0.7	-0.6	-0.4
Condit. Reinf. active responses	0.6	0.8	1.6	-1.3	0.8	0.6	-0.6	-0.9
Condit. Reinf. inactive responses	0.2	0.2	0.8	-0.1	0.4	0.4	-0.3	-0.9
Incentive salience index mean	0.1	0.2	0.5	-0.7	0.5	0.3	-0.1	-0.2
Condit. Reinf. lever presses	0.4	0.5	0.9	0.7	-0.4	-0.4	0.9	0.9
Condit. Reinf. active minus inactive responses	3.8	4.8	5.9	-2.4	2.3	2.1	-1.9	-2.2
Condit. Reinf. active-inactive response ratio	4.6	4.8	6.4	-2.5	2.3	2.3	-2.0	-1.8
Condit. Reinf. active responses	3.7	5.1	6.0	-2.5	2.3	2.1	-2.0	-2.4
Condit. Reinf. inactive responses	0.3	0.3	1.5	-0.0	0.1	-0.0	-0.2	-1.2
Condit. Reinf. lever presses	0.3	0.4	0.8	-0.9	0.7	0.6	-0.3	-0.6
Condit. Reinf. lever reinforcers received	3.2	4.5	5.7	-2.4	2.2	2.0	-1.8	-2.2
Conditioned reinforcement - actives	1.0	1.0	1.9	-0.1	0.7	0.8	-1.3	-1.4
Conditioned reinforcement - inactives	0.1	0.1	0.1	-0.2	0.2	0.3	-0.3	-0.2
Conditioned locomotion	2.1	2.5	3.2	-1.8	1.7	1.8	-1.4	-1.2
Patch foraging indifference point 0 sec	0.3	0.5	1.1	0.1	-0.7	-0.9	1.0	0.1
Patch foraging indifference point AUC	0.1	0.1	0.2	-0.5	-0.5	-0.4	0.1	-0.2
Delay disc. indifference point, 0s delay	0.3	0.3	0.5	-0.7	0.6	0.7	-0.4	0.1
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	-0.2	-0.6	-0.5	0.5	0.5
Delay disc. indifference point, 2s delay	0.4	0.5	0.8	-0.9	0.5	0.5	-0.6	-0.8
Delay disc. indifference point, 24s delay	0.3	0.3	0.6	-0.8	0.6	0.6	-0.4	-0.4
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.4	-0.0	0.0	-0.3	-0.3
Delay disc. indifference point, 8s delay	0.8	0.8	1.3	0.7	-1.2	-1.1	0.7	0.7
Indifference point function ln k	0.4	0.5	1.9	0.6	0.2	0.2	-0.6	-1.4
Indifference point function log k	0.4	0.5	1.9	0.6	0.2	0.2	-0.6	-1.4
Patch foraging total patch changes 0 sec	0.4	0.6	1.2	0.2	-0.8	-1.0	1.1	0.2
Patch foraging total patch changes 12 sec	0.2	0.2	0.9	-1.0	0.1	-0.1	0.0	-0.4
Patch foraging total patch changes 18 sec	1.5	1.9	3.3	0.8	-1.6	-1.8	1.6	0.9
Patch foraging total patch changes 24 sec	0.1	0.1	0.3	-0.5	-0.1	-0.4	0.2	-0.5
Patch foraging total patch changes 6 sec	0.3	0.5	0.8	-0.8	-0.6	-0.7	0.9	0.3
Patch foraging time to switch 0 sec	0.2	0.3	0.7	-0.5	0.5	0.5	0.1	0.8
Patch foraging water rate 0 sec	0.1	0.2	0.5	0.2	-0.6	-0.7	0.4	-0.3
Patch foraging water rate 12 sec	1.4	2.1	2.5	1.4	-1.6	-1.6	1.6	1.0
Patch foraging water rate 18 sec	0.2	0.2	0.9	1.0	-0.3	-0.3	0.2	-0.3
Patch foraging water rate 24 sec	0.1	0.2	0.5	0.6	-0.1	-0.1	-0.3	-0.7
Patch foraging water rate 6 sec	0.5	0.8	1.3	1.1	-1.0	-1.1	0.7	0.0
Seeking ratio, delayed vs. immediate footshock	0.8	1.0	1.4	0.1	-1.0	-1.0	1.2	1.2
Distance traveled before self-admin	0.1	0.1	0.2	-0.2	-0.4	-0.2	0.1	0.1
Distance traveled after self-admin	0.1	0.1	0.2	-0.1	-0.4	-0.4	0.2	0.2
Extensor digitorum longus weight	2.1	8.2	17.8	1.9	-2.3	-2.2	3.1	4.2
Bone: elastic displacement	1.1	1.2	3.1	1.8	-1.1	-1.1	0.8	0.3
Bone: elastic work	0.9	1.1	1.9	1.4	-0.8	-0.9	1.2	0.9
Bone: endosteal estimation	12.0	26.1	43.6	-6.6	5.2	5.2	-4.4	-3.6
Bone: endosteal perimeter	12.9	26.8	42.3	-6.5	5.3	5.3	-4.5	-3.9
Epididymis fat weight	5.7	13.3	28.5	1.7	-2.9	-2.9	4.3	5.3
Delta time in closed arm before/after self-admin	3.3	3.2	4.1	-1.5	1.8	2.0	-2.0	-1.6
Delta time in open arm before/after self-admin	0.4	0.4	1.1	1.1	-0.6	-0.5	0.1	-0.4
Diff in mean of infusions in LGA sessions	1.6	1.8	2.7	1.1	-1.2	-1.3	1.4	1.6
Delay discount exponential model param	0.3	0.3	0.9	1.0	-0.4	-0.4	0.5	0.5
Extinction: sum of active levers before priming	0.0	0.0	0.1	-0.2	-0.1	0.0	0.3	0.3
Active lever presses in extinction session 6	0.1	0.1	0.1	0.3	-0.1	-0.1	0.4	0.4
Bone: final force	0.6	1.0	1.6	-1.3	0.9	0.8	-0.8	-1.0
Bone: final moment	0.6	1.0	1.5	-1.2	0.9	0.7	-0.9	-1.2
Food consumed during 24 hour testing period	5.2	6.3	7.1	2.3	-2.6	-2.6	2.7	2.2
Glucose	0.0	0.0	0.0	-0.1	-0.2	-0.1	0.1	0.2
Heart weight	0.4	0.5	1.0	-1.0	0.9	0.9	0.1	0.0
Delay discount hyperbolic model param	0.2	0.2	0.7	0.8	-0.2	-0.3	0.4	0.4
Intermittent access intake day 1-15 change	0.7	0.7	1.6	-1.3	0.7	0.9	-0.6	0.2
Intermittent access intake escalation	0.8	0.8	1.8	-1.3	0.7	0.9	-0.7	0.2
Intermittent access intake escalation 2	1.9	1.9	3.9	-2.0	1.3	1.5	-1.3	-0.4
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	-0.1	0.2	0.1	0.2	0.0
Intermitt. access day 15 inactive lever presses	0.4	0.5	1.7	0.2	-0.4	-0.4	0.7	1.3
Intermitt. access escalation Index	0.3	0.3	0.4	-0.4	0.4	0.5	-0.6	-0.6
Intermittent access day 1 total infusions	0.3	0.3	0.8	0.9	-0.5	-0.6	0.3	-0.1
Intermittent access day 15 total infusions	0.3	0.4	0.7	-0.8	0.6	0.7	-0.6	-0.0
Intermittent access terminal intake (last 3 days)	0.9	1.0	1.6	-1.3	1.0	1.1	-1.0	-0.5
Intermittent access total infusions	0.0	0.0	0.0	-0.0	-0.0	0.1	-0.2	-0.2
Intermittent access day 1 locomotion	0.1	0.1	0.1	-0.2	0.3	0.2	0.1	0.3
Intermittent access day 15 total locomotion	1.5	1.6	2.3	-1.5	1.4	1.5	-1.1	-0.7
Intermittent access total locomotion	0.1	0.1	0.4	-0.6	0.3	0.4	0.1	0.3
Intermittent access standard deviation	0.4	0.4	1.1	-1.0	0.6	0.6	-0.6	-0.1
Left kidney weight	0.4	1.0	1.9	1.0	-0.6	-0.7	1.4	1.2
Right kidney weight	0.2	0.5	1.5	-0.3	0.5	0.4	0.7	1.2
Cocaine induced anxiety	0.7	0.8	1.1	-0.6	1.0	1.0	-1.0	-0.9
Post-drug Anxiety	0.8	0.9	1.1	-0.9	1.0	1.0	-1.0	-0.7
Baseline Anxiety	1.0	1.0	1.2	0.9	-1.0	-1.1	1.1	0.9
Tail length	0.1	0.3	1.0	-1.0	0.5	0.5	0.3	0.5
Length with tail	0.2	0.8	2.2	-0.9	-0.1	-0.1	1.0	1.5
Length without tail	0.3	0.7	2.4	-0.0	-0.4	-0.4	0.8	1.6
Times rat made contact with spout	0.4	0.4	0.7	0.5	-0.6	-0.5	0.8	0.8
Lifetime Intake	0.1	0.1	0.1	0.4	-0.3	-0.2	-0.0	-0.2
Liver weight, left	0.2	0.3	0.8	-0.1	0.2	0.1	-0.7	-0.9
Liver weight, right	0.8	1.3	2.1	1.2	-1.3	-1.4	0.8	0.6
Locomotor activity	0.2	0.4	0.9	0.6	-0.4	-0.6	0.9	0.5
Locomotor testing distance	0.2	0.4	0.8	0.7	-0.5	-0.6	0.9	0.1
Locomotor testing rearing	1.5	2.4	3.5	1.3	-1.6	-1.6	1.9	1.3
Locomotion in novel chamber	0.2	0.3	0.6	0.2	-0.4	-0.5	0.6	0.8
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	0.2	-0.1	-0.1	0.1	0.1
Fecal boli incidents, locomotor time 1	2.3	2.5	3.4	-1.7	1.8	1.7	-1.5	-1.0
Change in fecal boli incidents, locomotor task	0.4	0.4	0.9	0.1	-0.9	-0.9	0.3	-0.1
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.8	0.9	-0.5	-0.4	0.1	-0.2
Bouts of movement, locomotor time 1	0.7	0.8	1.6	0.6	-0.6	-0.7	1.0	1.3
Total resting periods, locomotor time 1	0.2	0.3	1.0	0.1	-0.1	-0.1	0.5	1.0
Rest time, locomotor task time 1	0.0	0.0	0.1	-0.2	0.2	0.1	-0.1	0.4
Distance moved, locomotor task time 1	2.7	2.9	3.8	1.7	-2.0	-1.9	1.7	1.3
Vertical activity count, locomotor time 1	1.8	1.9	3.0	1.2	-1.7	-1.6	1.2	0.9
Time >=10cm from walls, locomotor time 2	4.9	5.2	5.4	2.3	-2.2	-2.2	2.3	2.3
Bouts of movement, locomotor time 2	4.4	4.7	5.8	1.8	-2.1	-2.2	2.4	2.3
Total resting periods, locomotor time 2	3.2	3.4	4.2	1.6	-1.8	-1.9	2.0	1.9
Rest time, locomotor task time 2	0.9	1.0	1.8	-0.7	1.1	1.0	-1.3	-0.9
Distance moved, locomotor task time 2	6.9	8.1	8.6	2.8	-2.9	-2.8	2.9	2.8
Vertical activity count, locomotor time 2	3.3	3.6	4.1	1.6	-2.0	-1.9	2.0	1.8
Light reinforcement 1	1.8	3.3	4.7	2.2	-1.9	-2.0	1.8	0.9
Light reinforcement 2	0.2	0.2	0.4	0.5	-0.2	-0.3	0.5	0.6
Bone: marrow area	11.8	25.5	42.7	-6.5	5.1	5.2	-4.4	-3.6
Bone: maximum diameter	4.8	8.8	12.3	-3.5	2.9	2.8	-2.8	-2.8
Bone: maximum force	1.1	1.9	3.3	-1.8	1.4	1.2	-1.1	-1.3
Bone: maximum moment	1.1	2.0	3.2	-1.8	1.4	1.2	-1.2	-1.4
Mean time between licks in bursts	0.4	0.5	1.9	-0.5	0.2	0.3	0.6	1.4
Mean num. licks in bursts	0.2	0.3	0.6	0.8	-0.6	-0.5	0.4	0.0
Cd content in liver	0.6	0.7	1.3	-0.2	1.1	1.1	-0.9	-0.1
Co content in liver	0.5	0.5	1.1	-0.5	0.9	1.1	-0.2	0.6
Cu content in liver	0.8	1.0	1.3	-0.8	1.2	1.0	-1.0	-0.9
Fe content in liver	0.1	0.2	0.5	-0.1	-0.1	0.1	-0.5	-0.7
K content in liver	1.7	1.7	2.6	-0.7	1.2	1.3	-1.4	-1.6
Mg content in liver	1.8	1.9	3.7	-0.3	1.2	1.1	-1.7	-1.9
Mn content in liver	2.3	2.6	4.5	-0.5	1.6	1.5	-1.8	-2.1
Na content in liver	0.4	0.4	1.2	-0.3	0.3	0.4	-0.8	-1.1
Rb content in liver	0.2	0.2	0.5	0.2	-0.3	-0.3	-0.5	-0.7
Se content in liver	0.1	0.2	0.6	0.8	-0.3	-0.3	0.2	0.1
Sr content in liver	0.1	0.1	0.2	-0.2	0.3	0.3	0.4	0.4
Zn content in liver	1.4	1.5	2.0	-0.3	1.4	1.4	-1.3	-1.4
Bone: minimum diameter	6.4	12.0	20.8	-4.6	3.7	3.5	-2.7	-2.5
Time in familiar zone, hab. session 1	1.4	1.3	2.7	-1.7	1.0	1.2	-0.9	-0.6
Time in novel zone, hab. session 1	0.9	0.9	2.0	1.4	-0.9	-1.0	0.7	0.4
Total zone transitions, hab. session 1	1.2	1.6	2.3	1.3	-1.0	-1.1	1.5	1.4
Total locomotion distance, hab. session 1	1.7	2.4	2.9	1.7	-1.6	-1.7	1.6	1.0
Locomotion velocity, hab. session 1	1.5	2.2	2.6	1.6	-1.5	-1.5	1.6	1.1
Time in familiar zone, hab. session 2	0.6	0.6	1.5	-1.2	0.6	0.7	-0.6	-0.6
Time in novel zone, hab. session 2	0.3	0.3	1.2	1.1	-0.2	-0.4	-0.0	-0.1
Total zone transitions, hab. session 2	2.2	2.9	4.1	2.0	-1.3	-1.5	1.9	1.7
Total locomotion distance, hab. session 2	3.7	4.9	6.2	2.5	-2.2	-2.3	2.3	1.7
Locomotion velocity, hab. session 2	3.6	4.9	6.6	2.6	-2.2	-2.3	2.2	1.7
Novel to familiar place preference ratio	1.3	1.4	2.8	-1.7	1.2	1.2	-0.8	-0.7
Novelty place preference	1.0	1.1	1.9	-1.4	1.1	1.1	-0.7	-0.5
Time in novel zone, NPP test	1.0	1.0	1.7	-1.3	1.1	1.0	-0.7	-0.7
Total zone transitions, NPP test	1.8	2.5	4.5	2.1	-1.6	-1.9	1.3	0.4
Total locomotion distance, NPP test	2.2	3.1	5.4	2.3	-1.9	-2.0	1.4	0.5
Locomotion velocity, NPP test	2.9	4.0	6.1	2.5	-2.1	-2.3	1.8	0.9
Intraocular pressure	0.1	0.1	0.3	0.3	-0.3	-0.2	0.5	0.0
Delta distance traveled before/after self-admin	1.0	1.0	1.8	1.3	-1.1	-1.1	0.8	0.5
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	-0.2	0.4	0.3	-0.4	-0.5
Parametrial fat weight	0.9	1.8	2.6	-1.1	1.2	1.2	-1.6	-1.4
Pavlov. Cond. lever latency	1.2	1.5	3.0	-0.7	0.6	0.8	-1.7	-1.7
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	-0.6	0.2	0.2	0.1	0.2
Pavlov. Cond. change in total contacts	0.3	0.4	1.0	-0.1	-0.1	-0.0	0.9	1.0
Pavlov. Cond. index score	0.2	0.2	0.6	-0.2	-0.0	-0.1	0.8	0.8
Pavlov. Cond. latency score	0.4	0.5	1.4	-0.0	-0.2	-0.2	1.1	1.2
Pavlov. Cond. lever contacts	1.4	1.6	3.7	0.7	-0.6	-0.7	1.7	1.9
Pavlov. Cond. magazine entry number	0.2	0.2	0.6	0.8	-0.4	-0.4	0.1	0.0
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.4	-1.2	0.8	0.7	-0.4	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.5	-0.2	-0.0	0.0	0.7	0.7
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.2	0.1	0.1	0.5	0.5
Pavlov. Cond. lever latency	1.4	1.9	3.6	1.1	-1.3	-1.1	1.4	1.9
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.1	-0.2	-0.3	-0.2	-0.4
Pavlov. Cond. change in total contacts	0.8	1.1	2.1	-1.0	0.9	0.7	-1.0	-1.4
Pavlov. Cond. index score	0.9	1.2	1.8	-1.1	1.0	0.9	-1.0	-1.3
Pavlov. Cond. latency score	0.9	1.1	2.0	-1.0	0.9	0.7	-1.0	-1.4
Pavlov. Cond. lever contacts	0.5	0.7	1.7	-0.5	0.7	0.6	-0.8	-1.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	-0.2	0.4	0.6	-0.2	0.1
Pavlov. Cond. intertrial magazine entries	0.8	1.1	1.4	-1.0	1.2	1.2	-1.0	-0.9
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	2.0	-1.1	1.0	0.9	-1.1	-1.4
Pavlov. Cond. response bias	0.6	0.9	1.6	-0.8	0.9	0.7	-0.9	-1.3
Time in closed arm before self-admin	1.9	2.1	2.7	1.6	-1.4	-1.5	1.6	1.1
Time in closed arm after self-admin	0.1	0.1	0.2	0.1	-0.1	-0.0	0.3	0.5
Time in open arm before self-admin	0.5	0.5	1.9	-0.3	-0.4	-0.4	0.6	1.4
Time in open arm after self-admin	0.1	0.1	0.2	-0.1	-0.3	-0.3	0.3	0.5
Bone: periosteal estimation	6.3	12.9	22.0	-4.7	3.5	3.4	-3.1	-3.0
Bone: periosteal perimeter	5.0	8.3	14.5	-3.8	2.9	2.8	-2.4	-2.2
Bone: post-yield work	2.4	3.3	5.0	-2.2	2.1	2.1	-1.5	-0.9
Progressive ratio test 1 active lever presses	3.4	3.6	4.5	2.0	-2.1	-2.1	1.8	1.3
Progressive ratio test 1 breakpoint	3.3	3.4	4.3	1.9	-2.0	-2.1	1.9	1.3
Progressive ratio test 1 inactive lever presses	0.8	0.9	1.1	1.0	-0.9	-1.0	1.0	0.7
Progressive ratio test 2 active lever presses	0.1	0.1	0.3	0.3	-0.5	-0.5	0.1	-0.0
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	0.3	-0.5	-0.5	0.1	-0.1
Progressive ratio test 2 inactive lever presses	0.5	0.5	0.7	-0.6	0.7	0.7	-0.9	-0.8
Incentive Sensitization - Responses	0.6	0.6	0.8	-0.8	0.5	0.6	-0.9	-0.9
Incentive Sensitization - Breakpoint	0.6	0.6	0.8	-0.9	0.5	0.6	-0.9	-0.9
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.7	0.2	-0.8	-0.7	0.7	0.7
Progressive ratio	0.5	0.6	0.8	-0.9	0.9	0.8	-0.7	-0.3
Food seeking constrained by brief footshock	1.1	1.3	2.2	-1.1	1.5	1.4	-0.9	-0.5
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.3	-0.1	-0.1	0.3	0.1
Retroperitoneal fat weight	2.5	8.3	18.6	1.3	-2.1	-2.1	3.5	4.3
Reaction time number correct	0.2	0.4	0.9	0.0	0.5	0.4	-0.7	-1.0
Reaction time mean minus median	0.2	0.3	1.3	-0.2	-0.0	0.1	0.3	1.1
Reaction time mean minus median AUC	0.3	0.4	0.7	-0.5	0.7	0.9	-0.7	-0.3
Reaction time num false alarms	0.4	0.5	0.9	-1.0	0.7	0.6	-0.3	-0.9
Reaction time num false alarms AUC	0.8	1.2	1.7	-1.3	1.1	1.0	-0.7	-1.1
Reaction time trials correct on left	0.2	0.4	0.9	0.0	0.5	0.4	-0.7	-1.0
Reaction time trials on left	0.3	0.4	1.0	-0.1	0.6	0.5	-0.8	-1.0
Reaction time mean	0.2	0.3	0.6	-0.6	0.4	0.6	-0.8	-0.4
Reaction time mean AUC	0.1	0.1	0.2	-0.3	0.2	0.3	-0.5	-0.1
Median of all reaction times	0.4	0.6	1.0	-0.7	0.5	0.6	-1.0	-0.8
Reaction time omissions	0.4	0.5	0.8	-0.6	0.8	0.9	-0.8	-0.1
Reaction time false alarm rate	0.3	0.4	1.0	-1.0	0.6	0.5	-0.1	-0.4
Reaction time premature initiation rate	0.1	0.2	0.5	-0.7	-0.3	-0.2	0.4	0.2
Reaction time premature initiations	0.2	0.3	0.7	-0.8	0.2	0.2	-0.3	-0.6
Std. dev. reaction times	0.2	0.3	0.5	-0.6	0.5	0.7	-0.7	0.1
Reaction time trials completed	0.3	0.4	1.0	-0.1	0.6	0.5	-0.8	-1.0
Reaction time trials AUC	0.3	0.4	0.9	-0.0	0.4	0.4	-0.7	-1.0
Run reversals in cocaine runway, females	6.3	6.1	12.4	1.2	-2.1	-2.1	2.8	3.5
Run reversals in cocaine runway, males	0.5	0.5	0.8	-0.7	0.9	0.9	-0.6	-0.4
Latency to leave start box in cocaine runway	6.5	7.0	9.5	2.7	-3.1	-3.1	2.5	1.6
Latency to leave start box in cocaine runway, F	5.8	6.3	7.6	2.3	-2.8	-2.8	2.7	1.9
Latency to leave start box in cocaine runway, M	2.9	2.8	3.8	1.9	-1.9	-1.9	1.3	1.0
Std. dev. time between licks in bursts	1.4	1.6	1.9	1.4	-1.2	-1.1	1.3	1.4
Total sessions with >9 infusions	0.5	0.6	1.1	1.1	-0.9	-0.8	0.7	0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.3	0.5	0.0	-0.2	0.3	0.1
Short access day 10 total inactive lever presses	0.3	0.4	0.6	-0.8	0.6	0.6	-0.6	-0.3
Short access day 1 total infusions	1.6	1.8	3.1	1.8	-1.5	-1.5	1.1	0.2
Short access day 10 total infusions	1.1	1.2	1.3	1.1	-1.1	-1.1	1.1	0.9
Short access total infusions	0.4	0.5	1.0	1.0	-0.7	-0.7	0.5	-0.1
Short access day 1 locomotion	1.1	1.2	1.6	1.2	-1.1	-1.1	1.3	0.8
Short access day 10 total locomotion	0.2	0.2	0.7	-0.3	0.0	-0.0	0.5	0.9
Short access total locomotion	1.5	1.6	2.3	1.0	-1.1	-1.2	1.5	1.4
One hour access (0.3 mA shock)	1.4	1.7	2.5	-1.2	1.0	1.2	-1.4	-1.6
Compulsive drug intake	2.8	2.9	4.1	-2.0	1.6	1.7	-1.6	-1.5
One hour access (shock baseline)	0.0	0.0	0.1	0.1	0.1	0.2	-0.2	-0.1
Social response proportion	1.5	1.6	2.3	-1.5	1.4	1.5	-1.1	-0.6
Social responses	0.0	0.0	0.1	-0.3	0.0	-0.1	0.1	-0.1
Social time	1.7	2.2	3.4	-1.7	1.8	1.7	-1.3	-0.5
Soleus weight	0.2	0.4	0.6	-0.7	0.7	0.7	0.3	0.8
Bone: stiffness	0.9	1.4	2.8	-1.7	1.2	1.0	-0.9	-0.8
Tibialis anterior weight	1.0	3.4	9.4	0.9	-1.0	-0.9	2.2	3.1
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.3	-1.1	0.7	0.8	-0.9	-0.3
Time to tail flick, vehicle, after self-admin	3.0	3.2	5.2	-2.3	1.7	1.7	-1.8	-1.3
Time to tail flick, test, before self-admin	2.9	2.9	5.9	-2.4	1.8	1.9	-1.1	-0.4
Time to tail flick, test, after self-admin	2.3	2.4	3.2	-1.8	1.6	1.5	-1.6	-1.4
Delta time to tail flick, vehicle, before/after SA	2.5	2.5	2.9	-1.5	1.5	1.5	-1.6	-1.7
Delta time to tail flick, test, before/after SA	2.0	1.8	2.9	-1.0	1.2	1.1	-1.6	-1.7
Tibia length	0.5	1.4	3.3	0.1	-0.7	-0.8	1.6	1.8
Ambulatory time before self-admin	0.6	0.6	1.1	0.4	-1.1	-0.9	0.8	0.7
Ambulatory time after self-admin	0.2	0.2	0.4	0.1	-0.6	-0.6	0.5	0.2
Bone: tissue strength	0.6	0.6	1.5	1.2	-0.7	-0.8	0.3	-0.3
Total heroin consumption	0.1	0.1	0.2	-0.4	0.2	0.2	-0.3	-0.3
Bone: trabecular number	4.1	6.5	7.8	-1.7	2.8	2.6	-2.8	-2.8
Bone: trabecular spacing	2.5	3.3	4.7	1.2	-2.2	-2.0	1.8	1.7
Bone: trabecular thickness	2.3	2.7	3.7	-1.6	1.9	1.7	-1.6	-1.5
Bone: trabecular tissue density	1.1	1.5	2.8	0.6	-1.7	-1.6	1.0	0.8
Water consumed over 24 hours	3.7	4.4	5.5	2.4	-2.2	-2.1	2.0	1.6
Number of responses in last shaping day	3.2	3.3	3.6	1.7	-1.9	-1.9	1.8	1.8