Hub : Genes

LOC102550051

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	LOC102550051	0.42	0.14	0.0e+00	0.4	0.41	0.42	0.41	3.0e-47	7.4e-49	4.1e-50	1.1e-48
2	Liver	isoform ratio	XR_005490376.2	0.26	0.15	0.0e+00	0.19	0.21	0.21	0.2	1.8e-20	9.7e-23	4.1e-23	5.7e-22
3	Liver	isoform ratio	XR_010055696.1	0.14	0.11	5.5e-11	0.08	0.08	0.1	0.08	2.0e-09	2.6e-09	3.3e-11	2.7e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	2.6	4.7	5.4	-2.0	2.3	-2.2
Area under the delay curve	0.0	0.0	0.0	0.0	-0.2	-0.1
BMI with tail	0.2	0.6	0.8	-0.8	0.9	-0.6
BMI without tail	0.2	1.1	1.3	-1.0	1.1	-1.0
Body weight	2.5	10.9	11.9	-3.3	3.5	-3.2
Weight adjusted by age	0.2	0.6	0.8	0.7	-0.9	0.6
Bone surface	0.7	1.4	1.7	-1.1	1.3	-1.2
Bone volume	1.1	2.1	2.5	-1.3	1.6	-1.5
Breakpoint value in progressive ratio session	1.4	2.4	2.6	-1.5	1.6	-1.6
Number of licking bursts	0.1	0.2	0.4	0.6	-0.6	0.2
Context. condit. distance diff. score	0.0	0.0	0.1	-0.2	0.3	0.0
Locomotion velocity, session 1	2.4	2.7	3.0	-1.7	1.6	-1.6
Locomotion distance, session 1	0.3	0.3	0.4	-0.6	0.5	-0.7
Locomotion velocity, session 2	0.1	0.1	0.1	-0.2	0.3	-0.3
Locomotion distance, session 2	0.6	0.9	1.0	-0.9	1.0	-1.0
Locomotion velocity, session 3	2.5	2.8	3.0	1.7	-1.7	1.6
Locomotion distance, session 3	0.2	0.3	0.4	0.5	-0.6	0.4
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	0.1	-0.1	0.1
Stereotopy head waving duration, day 3	0.1	0.2	0.2	0.5	-0.4	0.4
Locomotion velocity, session 7	0.0	0.0	0.0	-0.1	-0.0	0.1
Locomotion distance, session 7	0.0	0.0	0.0	-0.0	-0.0	0.2
Stereotopy head waving bouts, day 7	1.0	1.2	1.2	-1.1	1.1	-1.1
Stereotopy head waving duration, day 7	0.6	0.7	0.7	-0.8	0.8	-0.8
Locomotion velocity, session 8	0.1	0.1	0.1	-0.3	0.3	-0.2
Locomotion distance, session 8	0.0	0.1	0.1	-0.2	0.3	-0.0
Degree of sensitization distance	1.1	1.2	1.4	-1.2	1.2	-0.9
Degree of sensitization stereotypy	1.2	1.4	1.4	-1.2	1.2	-1.1
Conditioned locomotion	2.9	3.4	3.9	2.0	-1.8	1.7
Cocaine response after cond. corrected	0.1	0.2	0.3	-0.5	0.4	-0.2
Cocaine response after cond. not corrected	0.4	0.6	0.7	-0.8	0.8	-0.6
Cocaine response before conditioning	0.1	0.2	0.3	-0.4	0.5	-0.4
Saline control response	0.2	0.2	0.4	0.4	-0.4	0.6
Bone: connectivity density	3.1	5.0	5.6	-2.1	2.4	-2.2
Bone: cortical apparent density	0.1	0.2	0.3	0.5	-0.5	0.4
Bone: cortical area	1.8	3.0	3.2	1.8	-1.7	1.6
Bone: cortical porosity	0.1	0.1	0.2	0.3	-0.4	0.4
Bone: cortical porosity	0.3	0.4	0.4	0.6	-0.6	0.7
Bone: cortical thickness	3.0	5.0	5.7	2.4	-2.2	2.1
Bone: cortical thickness	0.1	0.2	0.3	0.6	-0.3	0.2
Bone: cortical tissue density	0.0	0.1	0.1	0.3	-0.3	0.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.4	-0.5	0.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.2	0.4	-0.5	0.3
Condit. Reinf. active responses	0.0	0.0	0.0	0.2	-0.2	0.1
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.0	-0.0	0.1
Incentive salience index mean	0.1	0.1	0.2	0.4	-0.4	0.1
Condit. Reinf. lever presses	0.1	0.1	0.1	-0.2	0.3	-0.4
Condit. Reinf. active minus inactive responses	0.3	0.5	0.6	0.7	-0.6	0.7
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.1	0.0	0.0
Condit. Reinf. active responses	0.4	0.6	0.7	0.8	-0.8	0.7
Condit. Reinf. inactive responses	0.4	0.6	0.7	0.8	-0.8	0.7
Condit. Reinf. lever presses	0.6	0.9	1.0	1.0	-1.0	0.7
Condit. Reinf. lever reinforcers received	0.5	0.7	0.9	0.9	-0.9	0.8
Conditioned reinforcement - actives	0.2	0.7	1.2	0.8	-0.5	1.1
Conditioned reinforcement - inactives	0.1	0.2	0.4	0.6	-0.3	0.3
Conditioned locomotion	0.7	1.0	1.3	1.1	-0.7	1.1
Patch foraging indifference point 0 sec	0.0	0.1	0.1	0.2	-0.4	0.1
Patch foraging indifference point AUC	1.0	2.4	2.9	1.7	-1.5	1.4
Delay disc. indifference point, 0s delay	0.7	0.8	0.9	0.9	-0.9	0.8
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.4	0.3	-0.5
Delay disc. indifference point, 2s delay	0.8	0.9	1.0	0.9	-1.0	0.9
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.3	0.2	-0.4
Delay disc. indifference point, 4s delay	0.7	0.8	1.0	-1.0	0.8	-0.8
Delay disc. indifference point, 8s delay	0.2	0.3	0.4	-0.6	0.4	-0.6
Indifference point function ln k	1.7	5.1	5.9	-2.4	2.1	-2.2
Indifference point function log k	1.7	5.1	5.9	-2.4	2.1	-2.2
Patch foraging total patch changes 0 sec	0.0	0.1	0.1	0.2	-0.3	0.1
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	0.4	-0.3	0.2
Patch foraging total patch changes 18 sec	0.7	1.6	1.7	1.3	-1.3	1.2
Patch foraging total patch changes 24 sec	0.3	0.9	1.2	1.1	-1.0	0.7
Patch foraging total patch changes 6 sec	1.7	2.9	3.3	1.8	-1.8	1.5
Patch foraging time to switch 0 sec	0.1	0.3	0.5	-0.6	0.7	-0.3
Patch foraging water rate 0 sec	0.3	1.0	1.3	1.0	-1.2	0.8
Patch foraging water rate 12 sec	0.5	1.9	2.5	-1.3	1.1	-1.6
Patch foraging water rate 18 sec	0.9	2.0	2.2	-1.5	1.3	-1.4
Patch foraging water rate 24 sec	0.0	0.0	0.1	-0.2	0.1	-0.3
Patch foraging water rate 6 sec	0.0	0.0	0.1	0.2	-0.3	-0.1
Seeking ratio, delayed vs. immediate footshock	2.4	3.4	3.7	1.7	-1.9	1.9
Distance traveled before self-admin	0.5	1.0	1.3	1.0	-1.2	0.9
Distance traveled after self-admin	0.1	0.2	0.3	0.5	-0.3	0.5
Extensor digitorum longus weight	0.2	1.0	1.1	-0.9	1.0	-1.0
Bone: elastic displacement	1.6	2.1	2.2	1.5	-1.5	1.4
Bone: elastic work	6.3	8.2	9.3	3.1	-2.9	2.6
Bone: endosteal estimation	0.0	0.0	0.0	-0.2	0.1	-0.1
Bone: endosteal perimeter	0.2	0.4	0.6	-0.7	0.6	-0.5
Epididymis fat weight	5.7	28.7	30.2	-5.5	5.4	-5.1
Delta time in closed arm before/after self-admin	0.3	0.3	0.5	0.4	-0.7	0.5
Delta time in open arm before/after self-admin	1.4	1.6	2.2	-1.1	1.5	-1.2
Diff in mean of infusions in LGA sessions	0.5	0.9	1.2	-0.9	1.1	-0.9
Delay discount exponential model param	0.0	0.0	0.1	0.2	0.0	0.3
Extinction: sum of active levers before priming	0.9	1.3	1.6	-1.0	1.2	-1.2
Active lever presses in extinction session 6	0.0	0.0	0.0	-0.1	0.1	-0.1
Bone: final force	1.0	1.6	1.8	1.3	-1.2	1.3
Bone: final moment	0.9	1.4	1.6	1.2	-1.1	1.2
Food consumed during 24 hour testing period	0.2	0.5	0.5	0.7	-0.7	0.6
Glucose	2.5	4.0	4.7	1.9	-2.0	2.2
Heart weight	0.7	1.2	1.2	-1.1	1.1	-1.1
Delay discount hyperbolic model param	0.0	0.0	0.0	0.0	0.2	0.1
Intermittent access intake day 1-15 change	0.3	1.5	1.7	1.2	-1.2	1.3
Intermittent access intake escalation	0.2	1.3	1.5	1.1	-1.1	1.2
Intermittent access intake escalation 2	0.8	1.4	1.5	1.1	-1.2	1.2
Intermitt. access day 1 inactive lever presses	0.1	0.7	0.7	0.8	-0.8	0.8
Intermitt. access day 15 inactive lever presses	0.4	2.3	3.0	1.7	-1.4	1.4
Intermitt. access escalation Index	1.3	4.0	4.3	-1.9	2.1	-2.1
Intermittent access day 1 total infusions	0.0	0.0	0.0	-0.1	0.2	-0.0
Intermittent access day 15 total infusions	0.0	0.1	0.2	0.4	-0.2	0.4
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	-0.2	0.3	0.0
Intermittent access total infusions	0.2	0.2	0.4	0.4	-0.4	0.6
Intermittent access day 1 locomotion	0.3	0.5	0.6	0.8	-0.6	0.7
Intermittent access day 15 total locomotion	0.2	0.7	0.9	0.9	-0.8	0.8
Intermittent access total locomotion	0.5	0.6	0.7	0.9	-0.7	0.8
Intermittent access standard deviation	0.5	2.4	3.0	1.5	-1.4	1.7
Left kidney weight	0.0	0.2	0.3	-0.4	0.5	-0.3
Right kidney weight	0.0	0.3	0.4	-0.5	0.6	-0.4
Cocaine induced anxiety	0.1	0.4	0.4	-0.6	0.6	-0.6
Post-drug Anxiety	1.7	2.0	2.1	-1.3	1.5	-1.4
Baseline Anxiety	0.0	0.1	0.1	0.4	-0.1	0.2
Tail length	0.6	3.3	3.5	-1.8	1.8	-1.9
Length with tail	2.7	11.8	12.3	-3.4	3.4	-3.5
Length without tail	1.0	5.5	5.6	-2.3	2.3	-2.4
Times rat made contact with spout	0.0	0.0	0.0	-0.1	-0.1	-0.0
Lifetime Intake	0.0	0.0	0.0	0.1	0.0	0.2
Liver weight, left	4.9	8.4	9.4	-2.9	3.1	-2.7
Liver weight, right	5.4	9.4	10.1	-3.2	3.2	-2.9
Locomotor activity	0.0	0.0	0.0	-0.0	0.0	0.1
Locomotor testing distance	0.0	0.0	0.0	0.0	-0.1	0.2
Locomotor testing rearing	0.1	0.3	0.3	0.6	-0.5	0.5
Locomotion in novel chamber	1.2	1.6	2.0	1.2	-1.4	1.2
Locomotion in novel chamber post-restriction	0.2	0.7	1.2	-1.1	0.7	-0.6
Fecal boli incidents, locomotor time 1	0.1	0.4	0.7	0.5	-0.4	0.8
Change in fecal boli incidents, locomotor task	0.8	0.9	1.3	-0.9	0.7	-1.1
Time >=10cm from walls, locomotor time 1	1.5	1.9	2.2	1.5	-1.2	1.4
Bouts of movement, locomotor time 1	1.3	1.7	2.0	1.4	-1.3	1.2
Total resting periods, locomotor time 1	1.6	1.8	2.2	1.5	-1.3	1.2
Rest time, locomotor task time 1	0.5	0.8	0.9	1.0	-0.9	0.9
Distance moved, locomotor task time 1	0.2	0.5	0.6	-0.8	0.7	-0.7
Vertical activity count, locomotor time 1	0.1	0.7	0.9	-0.9	0.8	-0.7
Time >=10cm from walls, locomotor time 2	0.6	1.7	1.9	1.4	-1.2	1.4
Bouts of movement, locomotor time 2	0.2	0.6	0.8	0.7	-0.7	0.9
Total resting periods, locomotor time 2	0.1	0.6	0.7	0.7	-0.7	0.9
Rest time, locomotor task time 2	0.6	1.0	1.0	1.0	-1.0	0.9
Distance moved, locomotor task time 2	0.4	0.5	0.6	-0.7	0.8	-0.7
Vertical activity count, locomotor time 2	0.2	0.5	0.7	-0.7	0.9	-0.5
Light reinforcement 1	0.1	0.4	0.5	-0.7	0.6	-0.6
Light reinforcement 2	0.0	0.1	0.1	-0.3	0.2	-0.1
Bone: marrow area	0.0	0.0	0.0	-0.1	-0.0	-0.0
Bone: maximum diameter	0.3	0.6	0.7	0.8	-0.8	0.8
Bone: maximum force	1.5	3.0	3.3	1.8	-1.7	1.7
Bone: maximum moment	1.4	2.6	2.9	1.7	-1.6	1.6
Mean time between licks in bursts	0.0	0.1	0.1	0.3	-0.2	0.4
Mean num. licks in bursts	0.1	0.3	0.4	-0.7	0.5	-0.3
Cd content in liver	0.0	0.0	0.0	-0.1	-0.0	-0.2
Co content in liver	0.6	0.7	0.8	0.7	-0.9	0.8
Cu content in liver	1.1	1.3	1.4	1.2	-1.2	1.0
Fe content in liver	3.6	4.5	4.8	-2.0	2.1	-2.2
K content in liver	0.1	0.1	0.1	-0.3	0.3	-0.2
Mg content in liver	0.3	0.4	0.4	0.6	-0.6	0.6
Mn content in liver	0.3	0.4	0.4	0.6	-0.6	0.6
Na content in liver	1.5	1.7	2.0	-1.2	1.4	-1.3
Rb content in liver	0.3	0.3	0.5	0.5	-0.5	0.7
Se content in liver	1.2	1.5	1.6	1.3	-1.1	1.2
Sr content in liver	0.2	0.1	0.2	-0.3	0.4	-0.4
Zn content in liver	0.1	0.1	0.2	-0.4	0.4	-0.1
Bone: minimum diameter	0.0	0.0	0.0	0.1	-0.1	0.1
Time in familiar zone, hab. session 1	0.0	0.0	0.0	0.2	-0.1	-0.1
Time in novel zone, hab. session 1	0.0	0.0	0.0	-0.0	0.0	0.2
Total zone transitions, hab. session 1	0.0	0.0	0.0	0.1	0.1	-0.1
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.2	0.0	-0.1
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.4	-0.2	0.1
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.2	0.4	-0.5
Time in novel zone, hab. session 2	0.4	0.4	0.6	0.5	-0.7	0.8
Total zone transitions, hab. session 2	0.1	0.1	0.1	-0.2	0.4	-0.2
Total locomotion distance, hab. session 2	0.2	0.2	0.3	0.6	-0.4	0.4
Locomotion velocity, hab. session 2	0.2	0.2	0.4	0.6	-0.4	0.4
Novel to familiar place preference ratio	0.0	0.0	0.0	-0.0	-0.0	0.2
Novelty place preference	0.0	0.1	0.1	-0.3	0.2	-0.1
Time in novel zone, NPP test	0.1	0.1	0.2	-0.4	0.3	-0.2
Total zone transitions, NPP test	0.0	0.0	0.0	-0.1	0.1	-0.0
Total locomotion distance, NPP test	0.6	0.9	1.0	1.0	-0.9	0.8
Locomotion velocity, NPP test	0.8	1.2	1.3	1.2	-1.1	1.0
Intraocular pressure	1.7	2.7	3.1	1.6	-1.8	1.6
Delta distance traveled before/after self-admin	0.2	0.2	0.4	-0.4	0.7	-0.2
Delta ambulatory time before/after self-admin	0.8	1.4	1.8	-1.1	1.3	-1.1
Parametrial fat weight	6.1	14.4	16.0	-4.0	3.9	-3.5
Pavlov. Cond. lever latency	0.0	0.0	0.0	0.0	-0.0	0.1
Pavlov. Cond. magazine entry latency	0.5	0.7	0.8	-0.7	0.8	-0.9
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.2	-0.1	-0.0
Pavlov. Cond. index score	0.1	0.2	0.3	-0.3	0.4	-0.5
Pavlov. Cond. latency score	0.1	0.2	0.2	-0.3	0.4	-0.5
Pavlov. Cond. lever contacts	0.1	0.1	0.1	-0.2	0.3	-0.3
Pavlov. Cond. magazine entry number	0.2	0.3	0.5	0.4	-0.5	0.7
Pavlov. Cond. intertrial magazine entries	0.6	0.7	0.8	0.9	-0.9	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.2	0.3	-0.5
Pavlov. Cond. response bias	0.4	0.5	0.7	-0.6	0.7	-0.8
Pavlov. Cond. lever latency	1.2	1.7	1.8	-1.3	1.3	-1.2
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	-0.3	0.2	-0.3
Pavlov. Cond. change in total contacts	0.4	0.9	1.0	1.0	-1.0	0.9
Pavlov. Cond. index score	0.7	1.2	1.3	1.1	-1.1	1.0
Pavlov. Cond. latency score	0.9	1.4	1.6	1.2	-1.3	1.1
Pavlov. Cond. lever contacts	0.6	0.8	0.9	1.0	-0.9	0.8
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.2	-0.1	0.2
Pavlov. Cond. intertrial magazine entries	0.1	0.3	0.4	-0.4	0.6	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.8	0.9	0.9	-0.9	0.8
Pavlov. Cond. response bias	0.2	0.3	0.3	0.6	-0.6	0.4
Time in closed arm before self-admin	1.4	2.4	2.6	-1.6	1.6	-1.4
Time in closed arm after self-admin	0.0	0.0	0.0	-0.0	-0.2	0.1
Time in open arm before self-admin	1.5	1.9	2.6	1.3	-1.6	1.2
Time in open arm after self-admin	0.0	0.0	0.1	-0.0	0.1	-0.2
Bone: periosteal estimation	0.4	0.9	1.0	0.9	-1.0	0.9
Bone: periosteal perimeter	0.1	0.2	0.3	0.4	-0.5	0.6
Bone: post-yield work	0.0	0.0	0.0	-0.1	0.1	-0.2
Progressive ratio test 1 active lever presses	0.2	0.4	0.4	0.6	-0.6	0.7
Progressive ratio test 1 breakpoint	0.2	0.4	0.4	0.6	-0.6	0.7
Progressive ratio test 1 inactive lever presses	1.3	3.4	3.8	1.9	-1.8	1.8
Progressive ratio test 2 active lever presses	1.5	2.1	2.2	1.5	-1.4	1.5
Progressive ratio test 2 breakpoint	1.6	2.0	2.1	1.5	-1.4	1.4
Progressive ratio test 2 inactive lever presses	0.8	2.4	2.7	1.5	-1.5	1.7
Incentive Sensitization - Responses	0.3	0.9	0.9	1.0	-0.9	0.9
Incentive Sensitization - Breakpoint	0.3	0.8	0.8	0.9	-0.8	0.9
Sum of active levers in priming session hrs 5-6	3.1	2.9	3.0	-1.6	1.7	-1.7
Progressive ratio	0.8	2.5	2.6	1.6	-1.5	1.6
Food seeking constrained by brief footshock	0.0	0.0	0.0	0.0	0.1	-0.1
Seeking ratio, punishment vs. effort	0.6	1.4	1.4	-1.2	1.2	-1.2
Retroperitoneal fat weight	2.0	9.1	9.7	-3.1	3.0	-2.9
Reaction time number correct	0.1	0.4	0.5	-0.7	0.4	-0.7
Reaction time mean minus median	0.1	0.9	1.0	-1.0	0.9	-0.9
Reaction time mean minus median AUC	0.4	2.7	2.9	-1.7	1.7	-1.6
Reaction time num false alarms	2.5	4.2	4.8	2.2	-2.1	1.9
Reaction time num false alarms AUC	2.4	5.5	6.2	2.5	-2.4	2.1
Reaction time trials correct on left	0.1	0.4	0.5	-0.7	0.4	-0.7
Reaction time trials on left	0.1	0.4	0.5	-0.7	0.3	-0.7
Reaction time mean	0.8	1.8	2.0	-1.4	1.4	-1.2
Reaction time mean AUC	0.7	1.6	1.8	-1.3	1.2	-1.2
Median of all reaction times	1.0	1.5	1.7	-1.3	1.3	-1.1
Reaction time omissions	0.7	1.2	1.5	-1.2	1.1	-1.0
Reaction time false alarm rate	3.7	5.1	6.0	2.4	-2.2	2.2
Reaction time premature initiation rate	2.0	3.1	3.4	-1.7	1.7	-1.8
Reaction time premature initiations	1.0	3.1	3.7	-1.7	1.6	-1.9
Std. dev. reaction times	0.2	0.7	0.8	-0.9	0.8	-0.8
Reaction time trials completed	0.1	0.4	0.5	-0.7	0.3	-0.7
Reaction time trials AUC	0.1	0.3	0.4	-0.6	0.3	-0.7
Run reversals in cocaine runway, females	0.0	0.0	0.0	-0.0	-0.0	0.1
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.5	0.2	-0.3
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.1	-0.3	0.1
Latency to leave start box in cocaine runway, F	0.0	0.0	0.0	-0.0	-0.1	0.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	-0.0	-0.2	-0.1
Std. dev. time between licks in bursts	1.3	2.4	2.7	1.5	-1.5	1.7
Total sessions with >9 infusions	0.7	0.8	1.0	-0.8	1.0	-0.9
Short access day 1 total inactive lever presses	0.3	0.5	0.8	-0.6	0.9	-0.6
Short access day 10 total inactive lever presses	0.0	0.2	0.3	0.6	-0.5	0.3
Short access day 1 total infusions	0.4	0.8	1.0	-0.7	0.9	-1.0
Short access day 10 total infusions	0.0	0.1	0.1	-0.2	0.4	0.1
Short access total infusions	0.0	0.0	0.1	-0.0	0.3	-0.1
Short access day 1 locomotion	0.0	0.0	0.1	0.2	-0.0	-0.1
Short access day 10 total locomotion	0.6	2.2	2.5	1.6	-1.5	1.4
Short access total locomotion	0.8	1.3	1.6	1.3	-1.1	1.0
One hour access (0.3 mA shock)	1.0	1.2	1.6	1.1	-0.9	1.3
Compulsive drug intake	2.6	3.9	4.9	-1.8	1.9	-2.2
One hour access (shock baseline)	1.1	2.8	3.9	1.5	-1.5	2.0
Social response proportion	2.0	2.6	2.6	-1.6	1.6	-1.6
Social responses	0.6	0.9	0.9	-0.9	0.9	-0.9
Social time	0.6	0.9	1.0	-1.0	1.0	-0.9
Soleus weight	2.3	6.7	7.1	-2.6	2.7	-2.5
Bone: stiffness	0.3	0.5	0.6	-0.7	0.8	-0.5
Tibialis anterior weight	1.5	5.1	5.5	-2.2	2.3	-2.3
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	-0.3	0.5	-0.3
Time to tail flick, vehicle, after self-admin	0.4	0.9	1.0	-1.0	0.8	-1.0
Time to tail flick, test, before self-admin	0.2	0.2	0.3	0.4	-0.4	0.6
Time to tail flick, test, after self-admin	0.2	0.2	0.3	0.4	-0.5	0.3
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.1	-0.1	-0.1
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	0.5	-0.5	0.3
Tibia length	0.2	0.5	0.7	0.6	-0.7	0.8
Ambulatory time before self-admin	0.1	0.2	0.3	0.3	-0.5	0.4
Ambulatory time after self-admin	0.7	1.1	1.2	-1.1	1.1	-1.0
Bone: tissue strength	0.3	0.3	0.4	0.6	-0.6	0.5
Total heroin consumption	2.2	2.6	2.8	-1.6	1.7	-1.5
Bone: trabecular number	3.4	6.4	7.3	-2.3	2.7	-2.6
Bone: trabecular spacing	1.5	2.2	2.5	1.3	-1.6	1.5
Bone: trabecular thickness	0.5	0.7	0.8	-0.6	0.9	-0.9
Bone: trabecular tissue density	0.4	0.7	0.8	0.8	-0.8	0.9
Water consumed over 24 hours	0.3	0.6	0.6	-0.8	0.7	-0.8
Number of responses in last shaping day	0.0	0.0	0.1	0.3	-0.2	-0.2