Hub : Genes

LOC102550051

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression LOC102550051 0.42 0.14 0.0e+00 0.4 0.41 0.42 0.41 3.0e-47 7.4e-49 4.0e-50 8.3e-49
2 Liver isoform ratio XR_005490376.2 0.26 0.15 0.0e+00 0.19 0.21 0.21 0.2 1.8e-20 9.7e-23 4.0e-23 5.3e-22
3 Liver isoform ratio XR_010055696.1 0.14 0.11 5.5e-11 0.08 0.08 0.1 0.08 2.0e-09 2.6e-09 3.3e-11 3.4e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density2.74.75.42.0-2.32.2
Area under the delay curve0.00.00.0-0.00.20.1
BMI with tail0.20.60.80.8-0.90.6
BMI without tail0.41.11.31.0-1.11.0
Body weight2.510.811.83.3-3.43.2
Weight adjusted by age0.40.50.8-0.70.9-0.6
Bone surface0.81.41.71.1-1.31.2
Bone volume1.22.12.51.3-1.61.5
Breakpoint value in progressive ratio session2.02.42.51.5-1.61.6
Number of licking bursts0.10.20.4-0.60.5-0.2
Context. condit. distance diff. score0.00.00.10.2-0.3-0.0
Locomotion velocity, session 12.52.73.01.7-1.61.6
Locomotion distance, session 10.30.30.40.6-0.60.7
Locomotion velocity, session 20.10.10.10.2-0.30.3
Locomotion distance, session 20.60.91.00.9-1.01.0
Locomotion velocity, session 32.52.83.0-1.71.7-1.6
Locomotion distance, session 30.20.30.4-0.50.6-0.4
Stereotopy head waving bouts, day 30.00.00.0-0.10.1-0.1
Stereotopy head waving duration, day 30.10.20.2-0.50.4-0.4
Locomotion velocity, session 70.00.00.00.10.0-0.1
Locomotion distance, session 70.00.00.00.00.0-0.2
Stereotopy head waving bouts, day 71.11.21.21.1-1.11.1
Stereotopy head waving duration, day 70.60.70.70.8-0.80.8
Locomotion velocity, session 80.10.10.10.3-0.30.2
Locomotion distance, session 80.00.00.10.2-0.30.0
Degree of sensitization distance1.21.21.41.2-1.20.9
Degree of sensitization stereotypy1.31.41.41.2-1.21.1
Conditioned locomotion2.93.43.9-2.01.8-1.7
Cocaine response after cond. corrected0.10.20.30.5-0.40.2
Cocaine response after cond. not corrected0.50.60.70.8-0.80.6
Cocaine response before conditioning0.10.20.30.4-0.50.4
Saline control response0.20.20.4-0.40.4-0.6
Bone: connectivity density3.25.05.62.1-2.42.2
Bone: cortical apparent density0.20.20.3-0.50.5-0.4
Bone: cortical area1.93.03.2-1.81.7-1.6
Bone: cortical porosity0.10.10.2-0.30.4-0.4
Bone: cortical porosity0.30.40.4-0.60.6-0.7
Bone: cortical thickness3.05.05.7-2.42.2-2.1
Bone: cortical thickness0.10.20.3-0.60.3-0.2
Bone: cortical tissue density0.10.10.1-0.30.3-0.2
Condit. Reinf. active minus inactive responses0.10.10.2-0.40.5-0.2
Condit. Reinf. active-inactive response ratio0.10.20.2-0.40.5-0.3
Condit. Reinf. active responses0.00.00.1-0.20.2-0.1
Condit. Reinf. inactive responses0.00.00.0-0.00.0-0.1
Incentive salience index mean0.10.10.1-0.40.4-0.1
Condit. Reinf. lever presses0.10.10.10.2-0.30.4
Condit. Reinf. active minus inactive responses0.40.50.6-0.70.7-0.7
Condit. Reinf. active-inactive response ratio0.00.00.0-0.1-0.0-0.0
Condit. Reinf. active responses0.40.60.7-0.80.8-0.7
Condit. Reinf. inactive responses0.50.60.7-0.80.8-0.7
Condit. Reinf. lever presses0.60.91.0-1.01.0-0.7
Condit. Reinf. lever reinforcers received0.50.70.9-0.90.9-0.8
Conditioned reinforcement - actives0.40.71.2-0.80.5-1.1
Conditioned reinforcement - inactives0.10.20.4-0.60.3-0.3
Conditioned locomotion0.81.01.3-1.10.8-1.1
Patch foraging indifference point 0 sec0.00.10.1-0.20.3-0.1
Patch foraging indifference point AUC1.62.42.9-1.71.5-1.4
Delay disc. indifference point, 0s delay0.70.80.9-0.90.9-0.8
Delay disc. indifference point, 16s delay0.10.10.20.4-0.30.5
Delay disc. indifference point, 2s delay0.80.91.0-0.91.0-0.9
Delay disc. indifference point, 24s delay0.10.10.20.3-0.20.4
Delay disc. indifference point, 4s delay0.70.81.01.0-0.80.8
Delay disc. indifference point, 8s delay0.30.30.40.6-0.40.6
Indifference point function ln k2.95.15.92.4-2.12.2
Indifference point function log k2.95.15.92.4-2.12.2
Patch foraging total patch changes 0 sec0.00.00.1-0.20.3-0.1
Patch foraging total patch changes 12 sec0.10.10.2-0.40.3-0.2
Patch foraging total patch changes 18 sec1.01.61.7-1.31.3-1.2
Patch foraging total patch changes 24 sec0.50.91.2-1.11.0-0.7
Patch foraging total patch changes 6 sec1.92.93.3-1.81.7-1.5
Patch foraging time to switch 0 sec0.10.30.50.6-0.70.3
Patch foraging water rate 0 sec0.51.01.3-1.01.1-0.8
Patch foraging water rate 12 sec0.91.92.51.3-1.21.6
Patch foraging water rate 18 sec1.32.02.21.5-1.31.4
Patch foraging water rate 24 sec0.00.00.10.2-0.10.3
Patch foraging water rate 6 sec0.00.00.1-0.20.20.1
Seeking ratio, delayed vs. immediate footshock2.83.53.7-1.71.9-1.9
Distance traveled before self-admin0.71.01.3-0.91.1-0.9
Distance traveled after self-admin0.20.20.3-0.50.3-0.5
Extensor digitorum longus weight0.21.01.10.9-1.01.0
Bone: elastic displacement1.82.12.2-1.51.4-1.4
Bone: elastic work6.38.29.3-3.12.9-2.6
Bone: endosteal estimation0.00.00.00.2-0.10.1
Bone: endosteal perimeter0.20.40.60.7-0.60.5
Epididymis fat weight8.428.630.25.5-5.45.1
Delta time in closed arm before/after self-admin0.30.30.5-0.40.7-0.5
Delta time in open arm before/after self-admin1.61.62.11.1-1.41.2
Diff in mean of infusions in LGA sessions0.70.91.10.9-1.10.9
Delay discount exponential model param0.00.00.1-0.20.0-0.3
Extinction: sum of active levers before priming1.21.31.61.0-1.21.2
Active lever presses in extinction session 60.00.00.00.1-0.10.1
Bone: final force1.01.71.8-1.31.2-1.3
Bone: final moment0.91.41.6-1.31.1-1.2
Food consumed during 24 hour testing period0.30.50.6-0.70.7-0.6
Glucose2.54.04.7-1.92.0-2.2
Heart weight0.81.21.21.1-1.11.1
Delay discount hyperbolic model param0.00.00.0-0.0-0.2-0.1
Intermittent access intake day 1-15 change0.71.51.7-1.21.2-1.3
Intermittent access intake escalation0.61.31.5-1.11.1-1.2
Intermittent access intake escalation 21.21.31.5-1.11.2-1.2
Intermitt. access day 1 inactive lever presses0.20.70.7-0.80.8-0.8
Intermitt. access day 15 inactive lever presses1.12.32.9-1.71.4-1.4
Intermitt. access escalation Index2.84.04.31.9-2.12.1
Intermittent access day 1 total infusions0.00.00.00.1-0.20.0
Intermittent access day 15 total infusions0.10.10.2-0.40.2-0.4
Intermittent access terminal intake (last 3 days)0.00.00.10.2-0.3-0.0
Intermittent access total infusions0.20.20.4-0.40.4-0.6
Intermittent access day 1 locomotion0.40.50.6-0.80.6-0.7
Intermittent access day 15 total locomotion0.40.70.9-0.90.8-0.8
Intermittent access total locomotion0.50.70.8-0.90.7-0.8
Intermittent access standard deviation1.22.53.0-1.51.4-1.7
Left kidney weight0.00.20.30.4-0.50.3
Right kidney weight0.10.20.30.5-0.60.4
Cocaine induced anxiety0.30.40.40.6-0.60.6
Post-drug Anxiety1.82.02.11.3-1.51.4
Baseline Anxiety0.10.10.1-0.40.1-0.2
Tail length0.93.33.51.8-1.81.9
Length with tail2.711.912.33.4-3.43.5
Length without tail1.75.55.62.3-2.32.4
Times rat made contact with spout0.00.00.00.10.10.0
Lifetime Intake0.00.00.0-0.1-0.0-0.2
Liver weight, left5.08.39.22.9-3.02.7
Liver weight, right5.49.410.03.2-3.22.9
Locomotor activity0.00.00.00.00.0-0.1
Locomotor testing distance0.00.00.0-0.00.1-0.2
Locomotor testing rearing0.10.30.3-0.60.5-0.5
Locomotion in novel chamber1.21.61.9-1.21.4-1.2
Locomotion in novel chamber post-restriction0.40.71.21.1-0.70.6
Fecal boli incidents, locomotor time 10.30.40.7-0.50.4-0.8
Change in fecal boli incidents, locomotor task0.90.91.30.9-0.71.1
Time >=10cm from walls, locomotor time 11.81.92.2-1.51.3-1.4
Bouts of movement, locomotor time 11.51.72.0-1.41.3-1.2
Total resting periods, locomotor time 11.61.82.2-1.51.3-1.2
Rest time, locomotor task time 10.70.80.9-1.00.9-0.9
Distance moved, locomotor task time 10.30.50.60.8-0.70.7
Vertical activity count, locomotor time 10.30.70.90.9-0.80.7
Time >=10cm from walls, locomotor time 21.21.81.9-1.41.2-1.4
Bouts of movement, locomotor time 20.40.60.8-0.70.7-0.9
Total resting periods, locomotor time 20.30.60.7-0.70.7-0.9
Rest time, locomotor task time 20.81.01.0-1.01.0-0.9
Distance moved, locomotor task time 20.40.50.60.7-0.70.7
Vertical activity count, locomotor time 20.30.50.70.7-0.80.5
Light reinforcement 10.20.40.50.7-0.60.6
Light reinforcement 20.00.10.10.3-0.20.1
Bone: marrow area0.00.00.00.1-0.00.0
Bone: maximum diameter0.30.60.7-0.80.8-0.8
Bone: maximum force1.73.03.3-1.81.7-1.7
Bone: maximum moment1.52.62.9-1.71.6-1.6
Mean time between licks in bursts0.00.10.1-0.30.2-0.4
Mean num. licks in bursts0.20.30.40.7-0.50.3
Cd content in liver0.00.00.00.10.00.2
Co content in liver0.60.70.8-0.70.9-0.8
Cu content in liver1.11.31.4-1.21.2-1.0
Fe content in liver3.74.54.82.0-2.12.2
K content in liver0.10.10.10.3-0.30.2
Mg content in liver0.40.40.4-0.60.6-0.6
Mn content in liver0.30.40.4-0.60.6-0.6
Na content in liver1.61.72.01.2-1.41.3
Rb content in liver0.30.30.5-0.50.5-0.7
Se content in liver1.21.51.6-1.31.1-1.2
Sr content in liver0.20.10.20.3-0.40.4
Zn content in liver0.10.10.20.4-0.30.1
Bone: minimum diameter0.00.00.0-0.10.1-0.1
Time in familiar zone, hab. session 10.00.00.0-0.20.10.1
Time in novel zone, hab. session 10.00.00.00.00.0-0.2
Total zone transitions, hab. session 10.00.00.0-0.1-0.00.1
Total locomotion distance, hab. session 10.00.00.0-0.2-0.00.1
Locomotion velocity, hab. session 10.10.10.2-0.40.2-0.1
Time in familiar zone, hab. session 20.10.10.20.2-0.40.5
Time in novel zone, hab. session 20.40.40.6-0.50.7-0.8
Total zone transitions, hab. session 20.10.10.10.2-0.40.2
Total locomotion distance, hab. session 20.20.20.3-0.60.4-0.4
Locomotion velocity, hab. session 20.20.20.4-0.60.4-0.4
Novel to familiar place preference ratio0.00.00.00.00.1-0.2
Novelty place preference0.00.10.10.3-0.20.1
Time in novel zone, NPP test0.10.10.20.4-0.30.2
Total zone transitions, NPP test0.00.00.00.1-0.10.0
Total locomotion distance, NPP test0.60.91.0-1.00.9-0.8
Locomotion velocity, NPP test0.81.21.3-1.21.1-1.0
Intraocular pressure1.92.73.1-1.61.8-1.6
Delta distance traveled before/after self-admin0.20.20.40.4-0.60.2
Delta ambulatory time before/after self-admin1.11.41.81.1-1.31.1
Parametrial fat weight6.114.416.04.0-3.93.5
Pavlov. Cond. lever latency0.00.00.0-0.00.0-0.1
Pavlov. Cond. magazine entry latency0.50.70.80.7-0.80.9
Pavlov. Cond. change in total contacts0.00.00.0-0.20.10.0
Pavlov. Cond. index score0.10.20.30.3-0.40.5
Pavlov. Cond. latency score0.10.20.20.3-0.40.5
Pavlov. Cond. lever contacts0.10.10.10.2-0.30.3
Pavlov. Cond. magazine entry number0.20.30.5-0.40.5-0.7
Pavlov. Cond. intertrial magazine entries0.60.70.8-0.90.9-0.8
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.2-0.30.5
Pavlov. Cond. response bias0.40.50.70.6-0.60.8
Pavlov. Cond. lever latency1.21.71.81.3-1.31.2
Pavlov. Cond. magazine entry latency0.00.10.10.3-0.20.3
Pavlov. Cond. change in total contacts0.60.91.0-1.01.0-0.9
Pavlov. Cond. index score0.91.11.3-1.11.1-1.0
Pavlov. Cond. latency score1.11.41.6-1.21.3-1.1
Pavlov. Cond. lever contacts0.60.80.9-1.00.9-0.8
Pavlov. Cond. magazine entry number0.00.00.0-0.20.1-0.2
Pavlov. Cond. intertrial magazine entries0.20.30.40.4-0.60.6
Pavlov. Cond. lever-magazine prob. diff.0.60.70.9-0.90.9-0.8
Pavlov. Cond. response bias0.20.30.3-0.60.5-0.4
Time in closed arm before self-admin1.92.42.61.6-1.61.4
Time in closed arm after self-admin0.00.00.00.00.2-0.1
Time in open arm before self-admin1.71.92.5-1.31.6-1.2
Time in open arm after self-admin0.00.00.10.0-0.10.2
Bone: periosteal estimation0.40.90.9-0.91.0-0.9
Bone: periosteal perimeter0.10.20.3-0.40.5-0.6
Bone: post-yield work0.00.00.00.1-0.10.2
Progressive ratio test 1 active lever presses0.30.40.4-0.60.6-0.7
Progressive ratio test 1 breakpoint0.30.40.4-0.60.6-0.7
Progressive ratio test 1 inactive lever presses2.43.43.8-1.91.8-1.8
Progressive ratio test 2 active lever presses1.82.12.2-1.51.4-1.5
Progressive ratio test 2 breakpoint1.72.02.1-1.51.4-1.4
Progressive ratio test 2 inactive lever presses1.52.52.7-1.51.5-1.7
Incentive Sensitization - Responses0.60.90.9-1.00.9-0.9
Incentive Sensitization - Breakpoint0.60.80.8-0.90.8-0.9
Sum of active levers in priming session hrs 5-63.12.93.01.6-1.71.7
Progressive ratio1.62.52.6-1.61.5-1.6
Food seeking constrained by brief footshock0.00.00.0-0.0-0.10.1
Seeking ratio, punishment vs. effort1.01.41.41.2-1.21.2
Retroperitoneal fat weight2.19.19.73.1-3.02.9
Reaction time number correct0.20.40.50.7-0.40.7
Reaction time mean minus median0.40.91.01.0-0.90.9
Reaction time mean minus median AUC1.12.72.91.7-1.71.6
Reaction time num false alarms3.04.24.8-2.22.1-1.9
Reaction time num false alarms AUC3.55.56.2-2.52.4-2.1
Reaction time trials correct on left0.20.40.50.7-0.40.7
Reaction time trials on left0.20.40.50.7-0.30.7
Reaction time mean1.11.82.01.4-1.41.2
Reaction time mean AUC1.01.61.81.3-1.31.2
Median of all reaction times1.11.51.71.3-1.31.1
Reaction time omissions0.81.21.51.2-1.11.0
Reaction time false alarm rate3.75.16.0-2.42.2-2.2
Reaction time premature initiation rate2.23.13.41.7-1.71.8
Reaction time premature initiations1.73.13.71.7-1.61.9
Std. dev. reaction times0.40.70.80.9-0.80.8
Reaction time trials completed0.20.40.50.7-0.30.7
Reaction time trials AUC0.20.30.40.6-0.30.7
Run reversals in cocaine runway, females0.00.00.00.00.0-0.1
Run reversals in cocaine runway, males0.10.10.20.5-0.20.3
Latency to leave start box in cocaine runway0.00.00.1-0.10.3-0.1
Latency to leave start box in cocaine runway, F0.00.00.00.00.1-0.1
Latency to leave start box in cocaine runway, M0.00.00.00.00.20.1
Std. dev. time between licks in bursts1.82.42.7-1.51.5-1.7
Total sessions with >9 infusions0.70.81.00.8-1.00.9
Short access day 1 total inactive lever presses0.40.50.80.6-0.90.6
Short access day 10 total inactive lever presses0.10.20.3-0.60.5-0.3
Short access day 1 total infusions0.60.81.00.7-0.91.0
Short access day 10 total infusions0.00.10.10.2-0.3-0.1
Short access total infusions0.00.00.10.0-0.30.1
Short access day 1 locomotion0.00.00.1-0.20.00.1
Short access day 10 total locomotion1.22.22.5-1.61.5-1.4
Short access total locomotion1.11.31.6-1.31.1-1.0
One hour access (0.3 mA shock)1.11.31.6-1.11.0-1.3
Compulsive drug intake3.33.94.91.8-1.92.2
One hour access (shock baseline)1.92.83.9-1.51.5-2.0
Social response proportion2.32.62.71.6-1.61.6
Social responses0.70.90.90.9-0.90.9
Social time0.70.91.01.0-0.90.9
Soleus weight2.26.67.12.6-2.72.5
Bone: stiffness0.30.50.60.7-0.80.5
Tibialis anterior weight1.55.15.52.2-2.32.3
Time to tail flick, vehicle, before self-admin0.10.10.30.3-0.50.3
Time to tail flick, vehicle, after self-admin0.70.91.01.0-0.91.0
Time to tail flick, test, before self-admin0.20.20.3-0.40.4-0.6
Time to tail flick, test, after self-admin0.20.20.3-0.40.5-0.3
Delta time to tail flick, vehicle, before/after SA0.00.00.00.10.10.1
Delta time to tail flick, test, before/after SA0.20.20.3-0.50.5-0.3
Tibia length0.20.50.7-0.60.7-0.8
Ambulatory time before self-admin0.10.20.2-0.30.5-0.4
Ambulatory time after self-admin1.01.11.21.1-1.11.0
Bone: tissue strength0.30.30.3-0.60.6-0.5
Total heroin consumption2.22.52.81.6-1.71.5
Bone: trabecular number3.96.47.32.3-2.72.6
Bone: trabecular spacing1.62.22.6-1.31.6-1.5
Bone: trabecular thickness0.50.70.80.6-0.90.9
Bone: trabecular tissue density0.50.70.8-0.80.8-0.9
Water consumed over 24 hours0.40.60.60.8-0.70.8
Number of responses in last shaping day0.00.00.1-0.30.10.2