Hub : Genes

LOC102549998

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative polyA	XR_005487574.1	0.03	0.02	2.6e-04	0.02	0.02	0.02	0.02	2.6e-03	1.2e-03	1.5e-03	4.4e-03
2	Liver	isoform ratio	XR_005487574.1	0.25	0.11	0.0e+00	0.14	0.19	0.19	0.2	4.6e-15	4.3e-21	5.2e-21	1.5e-21
3	Liver	gene expression	LOC102549998	0.58	0.1	0.0e+00	0.32	0.36	0.35	0.35	1.4e-36	2.4e-41	8.6e-41	6.6e-41
4	Liver	alternative polyA	XR_005487575.1	0.04	0.02	3.4e-05	0.03	0.03	0.03	0.03	1.7e-04	1.9e-04	7.7e-04	6.0e-04
5	Liver	intron excision ratio	chr7_120398465_120405346	0.08	0.04	9.0e-07	0.06	0.05	0.04	0.05	1.0e-06	4.9e-06	8.8e-06	6.2e-06
6	Liver	intron excision ratio	chr7_120398465_120405359	0.09	0.05	2.2e-07	0.06	0.06	0.06	0.06	3.0e-07	3.4e-07	4.1e-07	3.5e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.4	0.7	1.9	1.3	-0.4	-0.3	1.4	0.2	-0.2
Area under the delay curve	0.7	0.7	1.9	1.0	0.1	0.1	1.4	-0.8	-0.8
BMI with tail	4.5	14.5	19.4	-4.4	3.7	4.2	-4.2	-3.2	-2.8
BMI without tail	2.4	4.9	7.3	-2.7	2.0	2.6	-2.6	-1.4	-1.7
Body weight	2.3	9.8	13.1	-3.6	3.2	3.4	-3.3	-2.6	-2.5
Weight adjusted by age	4.3	4.8	6.7	-2.6	2.5	2.4	-2.1	-1.8	-1.8
Bone surface	0.5	1.0	1.9	0.9	0.7	0.5	1.4	-0.9	-1.2
Bone volume	0.5	0.8	2.3	1.3	0.2	-0.0	1.5	-0.6	-0.8
Breakpoint value in progressive ratio session	0.8	0.9	1.6	-1.3	0.9	1.0	-1.1	-0.7	-0.7
Number of licking bursts	0.1	0.1	0.3	0.3	-0.1	-0.2	0.0	0.5	0.3
Context. condit. distance diff. score	0.7	0.8	2.4	-1.3	0.3	0.7	-1.6	0.0	-0.1
Locomotion velocity, session 1	0.2	0.3	0.5	-0.3	0.4	0.7	-0.3	-0.7	-0.5
Locomotion distance, session 1	1.0	1.3	3.2	1.8	-0.9	-0.8	1.8	0.4	0.2
Locomotion velocity, session 2	0.8	1.0	1.7	-0.9	1.0	1.3	-0.9	-0.9	-0.9
Locomotion distance, session 2	0.5	0.7	1.7	1.2	-0.8	-0.6	1.3	0.2	0.1
Locomotion velocity, session 3	1.3	1.5	3.6	-0.1	-1.4	-1.1	-0.4	1.9	1.4
Locomotion distance, session 3	0.3	0.3	0.6	0.5	-0.8	-0.5	0.0	0.7	0.6
Stereotopy head waving bouts, day 3	0.7	0.9	2.5	1.6	-0.1	-0.5	1.6	-0.1	-0.2
Stereotopy head waving duration, day 3	0.5	0.6	1.2	1.1	-0.5	-0.8	0.9	0.5	0.4
Locomotion velocity, session 7	0.6	0.6	1.9	-0.4	-0.5	-0.4	-1.4	0.5	1.0
Locomotion distance, session 7	0.2	0.2	0.8	-0.4	-0.3	-0.1	-0.9	0.0	0.5
Stereotopy head waving bouts, day 7	0.3	0.3	0.8	0.6	-0.4	-0.4	0.9	0.6	0.2
Stereotopy head waving duration, day 7	1.1	1.3	1.6	1.2	-1.2	-1.1	1.2	1.2	0.8
Locomotion velocity, session 8	0.4	0.5	1.7	-0.9	0.3	0.7	-1.3	-0.2	-0.1
Locomotion distance, session 8	0.6	0.9	1.5	-1.1	0.8	1.2	-0.8	-0.8	-1.0
Degree of sensitization distance	1.9	1.9	2.4	-1.5	1.5	1.4	-1.2	-1.4	-1.1
Degree of sensitization stereotypy	0.5	0.5	1.1	0.3	-0.8	-0.7	0.5	1.1	0.6
Conditioned locomotion	0.3	0.4	0.8	-0.7	0.4	0.6	-0.9	-0.6	-0.3
Cocaine response after cond. corrected	0.9	1.0	1.8	-1.3	0.9	1.0	-1.3	-0.7	-0.5
Cocaine response after cond. not corrected	1.8	2.0	4.0	-2.0	1.1	1.4	-1.9	-0.7	-0.6
Cocaine response before conditioning	0.6	0.8	1.3	-1.1	0.8	0.9	-1.2	-0.3	-0.5
Saline control response	2.7	3.6	5.0	-1.5	2.2	2.2	-1.0	-2.0	-2.0
Bone: connectivity density	0.3	0.5	1.2	1.1	-0.4	-0.2	1.1	0.5	-0.2
Bone: cortical apparent density	2.7	3.6	4.6	2.1	-2.0	-2.2	1.7	1.7	1.7
Bone: cortical area	1.2	1.9	3.3	-0.8	1.7	1.4	-0.8	-1.8	-1.4
Bone: cortical porosity	1.8	1.9	2.9	-0.8	1.6	1.7	-0.3	-1.6	-1.7
Bone: cortical porosity	2.8	3.1	4.7	-1.3	2.1	2.2	-0.5	-1.8	-2.1
Bone: cortical thickness	0.0	0.1	0.2	0.0	0.2	0.0	-0.3	-0.5	-0.0
Bone: cortical thickness	0.2	0.3	1.0	-0.3	0.0	-0.2	-1.0	-0.4	0.5
Bone: cortical tissue density	2.6	3.4	4.4	2.1	-1.9	-2.1	1.6	1.7	1.6
Condit. Reinf. active minus inactive responses	2.1	2.4	3.6	-1.1	1.8	1.9	-1.3	-1.7	-1.5
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	-0.1	0.5	0.7	-0.3	-0.5	-0.5
Condit. Reinf. active responses	2.8	3.4	4.7	-1.6	2.0	2.2	-1.7	-1.9	-1.6
Condit. Reinf. inactive responses	1.8	2.2	2.6	-1.4	1.6	1.6	-1.4	-1.5	-1.2
Incentive salience index mean	3.7	4.4	6.3	-1.6	2.4	2.5	-1.6	-2.3	-2.0
Condit. Reinf. lever presses	3.0	4.0	5.7	-1.7	2.2	2.4	-1.5	-2.1	-1.9
Condit. Reinf. active minus inactive responses	1.0	1.3	3.8	-0.0	1.3	0.8	0.1	-1.9	-1.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.8	0.2	0.4	0.2	-0.1	-0.9	-0.3
Condit. Reinf. active responses	2.1	2.9	6.2	-0.7	2.0	1.6	-0.6	-2.5	-1.8
Condit. Reinf. inactive responses	1.5	1.8	2.4	-1.1	1.5	1.4	-0.9	-1.5	-1.4
Condit. Reinf. lever presses	2.4	3.3	4.6	-1.4	2.1	2.0	-1.2	-2.2	-1.8
Condit. Reinf. lever reinforcers received	2.0	2.8	6.3	-0.7	2.0	1.6	-0.4	-2.5	-1.8
Conditioned reinforcement - actives	0.5	0.5	0.7	-0.8	0.8	0.8	-0.6	-0.6	-0.7
Conditioned reinforcement - inactives	0.2	0.2	0.6	-0.7	0.1	0.3	-0.8	0.1	0.0
Conditioned locomotion	3.0	3.6	5.4	-2.3	2.0	2.0	-2.1	-1.4	-1.4
Patch foraging indifference point 0 sec	0.3	0.5	0.7	-0.8	0.7	0.7	-0.8	-0.4	-0.5
Patch foraging indifference point AUC	2.4	2.8	5.9	0.2	1.6	1.6	1.0	-2.2	-2.4
Delay disc. indifference point, 0s delay	3.0	3.3	5.4	-0.7	2.2	2.0	-0.2	-2.3	-2.3
Delay disc. indifference point, 16s delay	0.5	0.5	0.9	0.4	0.6	0.6	0.6	-1.0	-0.9
Delay disc. indifference point, 2s delay	2.7	3.0	5.0	1.2	1.4	1.1	1.9	-2.2	-2.2
Delay disc. indifference point, 24s delay	0.3	0.3	0.5	-0.5	0.4	0.7	-0.6	-0.4	-0.3
Delay disc. indifference point, 4s delay	0.5	0.6	1.6	0.7	0.2	0.1	1.3	-0.8	-0.8
Delay disc. indifference point, 8s delay	0.7	0.8	2.1	1.2	-0.8	-0.7	1.4	0.1	0.1
Indifference point function ln k	1.0	1.4	4.1	-1.9	0.5	0.4	-2.0	0.0	0.4
Indifference point function log k	1.0	1.4	4.1	-1.9	0.5	0.4	-2.0	0.0	0.4
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	-0.5	0.3	0.3	-0.4	-0.1	-0.3
Patch foraging total patch changes 12 sec	1.3	1.7	3.7	-0.2	1.4	1.3	0.1	-1.7	-1.9
Patch foraging total patch changes 18 sec	0.7	0.9	1.8	1.2	0.2	0.2	1.3	-0.9	-1.0
Patch foraging total patch changes 24 sec	0.2	0.3	0.5	0.7	0.3	0.2	0.4	-0.5	-0.7
Patch foraging total patch changes 6 sec	0.8	1.2	2.8	-0.3	1.1	1.2	0.5	-1.1	-1.7
Patch foraging time to switch 0 sec	0.5	0.8	1.1	1.0	-1.1	-0.9	0.6	0.6	0.9
Patch foraging water rate 0 sec	0.4	0.7	2.0	-1.4	0.6	0.4	-1.2	0.1	0.0
Patch foraging water rate 12 sec	1.3	1.9	4.7	-2.2	1.4	1.1	-1.9	-0.5	-0.4
Patch foraging water rate 18 sec	1.6	2.1	5.8	-2.4	0.8	0.5	-2.4	0.2	0.5
Patch foraging water rate 24 sec	0.5	0.7	2.1	-1.4	0.1	0.1	-1.2	0.8	0.5
Patch foraging water rate 6 sec	0.4	0.6	1.6	-1.3	0.5	0.3	-1.2	0.1	0.2
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	0.9	0.9	-0.5	-0.8	0.8	0.4	0.5
Distance traveled before self-admin	1.1	1.1	1.8	1.3	-1.0	-1.2	1.1	0.8	0.9
Distance traveled after self-admin	0.2	0.2	0.5	0.0	-0.1	-0.4	-0.5	0.5	0.7
Extensor digitorum longus weight	0.2	0.7	1.7	-1.2	0.6	0.8	-1.3	-0.3	-0.2
Bone: elastic displacement	0.3	0.3	0.8	0.4	-0.4	-0.2	0.9	0.8	0.1
Bone: elastic work	0.4	0.5	0.8	-0.8	0.8	0.9	-0.4	-0.6	-0.7
Bone: endosteal estimation	0.7	1.5	2.4	-0.7	1.5	1.4	-0.4	-1.4	-1.4
Bone: endosteal perimeter	4.0	8.2	14.4	-1.2	3.5	3.2	-0.5	-3.8	-3.3
Epididymis fat weight	2.5	5.7	7.2	-1.9	2.7	2.7	-2.0	-2.5	-2.4
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.3	-0.2	-0.1	-0.3	0.3	0.4
Delta time in open arm before/after self-admin	0.0	0.0	0.1	0.1	0.2	-0.0	0.2	-0.3	-0.3
Diff in mean of infusions in LGA sessions	1.4	1.5	2.3	-1.5	1.2	1.3	-1.5	-0.8	-0.9
Delay discount exponential model param	0.5	0.5	1.7	-1.0	0.2	0.1	-1.3	0.5	0.5
Extinction: sum of active levers before priming	0.3	0.3	0.7	-0.2	0.6	0.6	0.2	-0.9	-0.7
Active lever presses in extinction session 6	1.4	1.3	2.6	-1.6	1.0	1.2	-1.5	-0.6	-0.6
Bone: final force	0.1	0.1	0.5	0.3	0.3	0.0	-0.0	-0.7	-0.1
Bone: final moment	0.0	0.1	0.2	0.5	0.1	-0.2	0.2	-0.3	0.1
Food consumed during 24 hour testing period	1.7	2.0	3.6	-1.9	1.3	1.3	-1.9	-1.1	-0.5
Glucose	0.2	0.3	1.0	0.7	0.1	-0.0	1.0	-0.2	-0.4
Heart weight	1.5	2.1	3.7	1.0	-1.6	-1.6	0.4	1.9	1.7
Delay discount hyperbolic model param	0.6	0.7	1.8	-1.0	-0.1	-0.1	-1.4	0.8	0.8
Intermittent access intake day 1-15 change	0.3	0.3	1.0	-1.0	0.3	0.4	-0.9	-0.1	-0.1
Intermittent access intake escalation	0.6	0.6	1.4	-1.2	0.6	0.7	-1.1	-0.4	-0.4
Intermittent access intake escalation 2	2.4	2.4	3.7	-1.9	1.7	1.5	-1.6	-1.2	-1.3
Intermitt. access day 1 inactive lever presses	1.8	2.0	2.4	-1.5	1.5	1.5	-1.2	-1.3	-1.2
Intermitt. access day 15 inactive lever presses	1.9	2.1	5.5	-2.4	0.8	1.0	-2.3	-0.1	-0.1
Intermitt. access escalation Index	1.0	0.9	1.2	1.0	-1.1	-1.1	0.7	1.0	0.9
Intermittent access day 1 total infusions	0.1	0.1	0.1	-0.2	-0.3	-0.1	-0.3	0.3	0.3
Intermittent access day 15 total infusions	0.1	0.1	0.4	-0.6	-0.1	0.1	-0.6	0.2	0.1
Intermittent access terminal intake (last 3 days)	1.9	2.0	4.0	-2.0	1.3	1.4	-1.7	-0.9	-0.9
Intermittent access total infusions	0.2	0.2	0.5	-0.7	0.3	0.5	-0.6	-0.2	-0.3
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.3	-0.1	0.2	-0.3	-0.0	-0.0
Intermittent access day 15 total locomotion	0.3	0.3	0.6	-0.8	0.4	0.7	-0.7	-0.4	-0.4
Intermittent access total locomotion	0.3	0.3	0.9	-0.9	-0.1	0.2	-1.0	0.2	0.2
Intermittent access standard deviation	0.6	0.6	1.1	-0.9	-0.4	-0.3	-1.0	0.8	0.8
Left kidney weight	2.6	7.2	14.2	-3.8	2.3	2.7	-3.5	-1.2	-1.6
Right kidney weight	5.6	15.7	27.6	-5.3	3.7	4.1	-4.8	-2.5	-2.6
Cocaine induced anxiety	1.6	1.8	4.8	-2.1	0.9	1.0	-2.2	-0.1	-0.1
Post-drug Anxiety	2.0	2.2	4.5	-2.1	1.4	1.4	-1.9	-0.8	-0.8
Baseline Anxiety	0.4	0.4	1.2	0.9	-0.2	-0.2	1.1	-0.3	-0.3
Tail length	0.4	1.1	1.9	1.2	-1.0	-1.0	1.4	1.0	0.4
Length with tail	0.0	0.1	0.2	0.2	0.3	-0.0	0.4	-0.2	-0.4
Length without tail	0.5	1.0	1.4	-1.2	1.1	0.9	-1.1	-1.0	-0.6
Times rat made contact with spout	1.7	2.0	3.6	-0.9	-1.4	-1.2	-1.1	1.7	1.9
Lifetime Intake	0.1	0.1	0.4	-0.6	-0.0	0.2	-0.6	0.1	0.1
Liver weight, left	0.2	0.4	0.8	-0.0	0.7	0.4	0.3	-0.9	-0.7
Liver weight, right	0.8	1.4	3.2	0.8	1.1	0.5	1.1	-1.8	-1.3
Locomotor activity	1.6	2.6	4.4	-0.8	2.1	1.8	-0.3	-1.8	-2.1
Locomotor testing distance	0.2	0.4	1.0	0.9	-0.3	-0.5	1.0	0.3	0.0
Locomotor testing rearing	2.0	3.0	5.4	0.1	2.0	1.6	0.8	-2.3	-2.3
Locomotion in novel chamber	0.7	0.9	1.6	-0.5	-0.7	-0.7	-0.9	1.3	1.3
Locomotion in novel chamber post-restriction	0.4	0.5	1.3	0.1	1.2	0.7	0.1	-0.7	-0.7
Fecal boli incidents, locomotor time 1	0.5	0.6	0.8	0.7	-0.9	-0.8	0.6	0.7	0.7
Change in fecal boli incidents, locomotor task	0.3	0.2	0.6	-0.8	0.6	0.4	-0.4	-0.3	-0.3
Time >=10cm from walls, locomotor time 1	1.0	1.0	1.3	-1.0	1.2	1.1	-0.6	-1.1	-1.1
Bouts of movement, locomotor time 1	0.1	0.1	0.4	-0.2	-0.1	0.0	-0.6	0.3	0.4
Total resting periods, locomotor time 1	0.1	0.2	0.3	0.2	-0.3	-0.3	-0.2	0.6	0.6
Rest time, locomotor task time 1	0.7	0.8	1.7	0.2	-0.9	-0.9	-0.2	1.1	1.3
Distance moved, locomotor task time 1	1.3	1.4	2.1	-0.9	1.4	1.3	-0.6	-1.3	-1.4
Vertical activity count, locomotor time 1	3.0	3.2	4.3	-1.4	2.1	1.9	-1.0	-2.0	-2.1
Time >=10cm from walls, locomotor time 2	2.9	3.1	4.3	-1.9	2.1	2.0	-1.4	-1.5	-1.6
Bouts of movement, locomotor time 2	0.4	0.4	0.8	0.7	-0.9	-0.7	0.6	0.4	0.6
Total resting periods, locomotor time 2	0.4	0.4	0.7	0.8	-0.8	-0.6	0.7	0.2	0.5
Rest time, locomotor task time 2	2.2	2.5	3.5	1.4	-1.8	-1.8	1.0	1.6	1.9
Distance moved, locomotor task time 2	3.7	4.3	5.8	-1.8	2.4	2.3	-1.5	-2.0	-2.2
Vertical activity count, locomotor time 2	4.3	4.7	5.8	-2.1	2.4	2.4	-1.7	-2.1	-2.2
Light reinforcement 1	1.0	1.7	2.3	-1.0	1.5	1.5	-0.7	-1.5	-1.5
Light reinforcement 2	4.6	6.2	8.7	-2.3	2.9	2.7	-1.6	-2.7	-2.6
Bone: marrow area	0.6	1.2	2.0	-0.6	1.4	1.2	-0.3	-1.3	-1.3
Bone: maximum diameter	2.0	3.7	5.3	-1.4	2.3	2.1	-1.4	-2.2	-1.9
Bone: maximum force	0.0	0.0	0.1	0.0	0.3	0.1	-0.1	-0.3	-0.1
Bone: maximum moment	0.0	0.0	0.0	0.2	0.0	-0.2	0.1	0.0	0.2
Mean time between licks in bursts	3.0	4.2	5.6	2.4	-2.2	-2.1	1.8	1.9	1.9
Mean num. licks in bursts	0.3	0.4	0.7	-0.5	-0.8	-0.6	-0.2	0.5	0.8
Cd content in liver	0.2	0.3	0.5	0.5	-0.5	-0.7	0.3	0.4	0.5
Co content in liver	1.1	1.3	2.1	-0.8	1.4	1.4	-0.5	-1.1	-1.3
Cu content in liver	4.4	5.4	8.0	2.0	-2.8	-2.7	1.0	2.2	2.7
Fe content in liver	0.2	0.2	0.6	-0.1	0.6	0.4	-0.1	-0.8	-0.4
K content in liver	0.1	0.1	0.2	0.5	-0.1	0.2	0.0	-0.1	-0.3
Mg content in liver	0.4	0.4	0.8	0.8	0.1	0.3	0.9	-0.4	-0.8
Mn content in liver	0.1	0.1	0.2	0.3	0.0	0.3	0.4	0.1	-0.5
Na content in liver	1.5	1.6	4.9	2.2	-0.4	-0.6	1.8	-0.9	-0.3
Rb content in liver	0.2	0.2	0.7	0.7	-0.1	-0.0	0.8	0.0	-0.3
Se content in liver	0.2	0.3	0.9	-0.8	0.0	0.4	-1.0	0.4	-0.1
Sr content in liver	2.5	2.3	3.3	1.4	-1.8	-1.7	0.9	1.4	1.6
Zn content in liver	0.1	0.1	0.3	0.2	-0.5	-0.4	-0.1	0.4	0.5
Bone: minimum diameter	1.0	1.8	3.8	-0.6	1.6	1.4	-0.7	-2.0	-1.3
Time in familiar zone, hab. session 1	0.5	0.4	1.1	-0.4	-0.7	-0.4	-0.3	1.0	0.8
Time in novel zone, hab. session 1	0.4	0.4	0.7	0.8	0.3	0.2	0.8	-0.6	-0.6
Total zone transitions, hab. session 1	1.3	1.8	4.2	1.7	-1.2	-1.2	2.0	0.5	0.5
Total locomotion distance, hab. session 1	0.2	0.3	0.6	0.0	0.4	0.5	0.7	-0.6	-0.8
Locomotion velocity, hab. session 1	0.3	0.4	0.8	0.1	0.5	0.5	0.8	-0.8	-0.9
Time in familiar zone, hab. session 2	0.7	0.7	2.3	-1.1	-0.1	0.3	-1.5	0.4	0.5
Time in novel zone, hab. session 2	1.1	1.1	3.1	1.5	-0.6	-0.7	1.7	0.5	-0.0
Total zone transitions, hab. session 2	0.1	0.1	0.1	-0.3	-0.3	-0.1	-0.3	0.1	0.2
Total locomotion distance, hab. session 2	0.7	0.9	1.7	-1.3	0.8	1.1	-0.8	-0.6	-0.8
Locomotion velocity, hab. session 2	0.7	1.0	1.7	-1.3	1.0	1.2	-0.8	-0.8	-0.9
Novel to familiar place preference ratio	1.1	1.1	1.8	0.8	-1.3	-1.1	0.3	1.3	1.2
Novelty place preference	1.0	1.0	1.9	0.6	-1.2	-1.0	0.1	1.4	1.1
Time in novel zone, NPP test	1.4	1.4	2.6	0.7	-1.5	-1.2	0.2	1.6	1.4
Total zone transitions, NPP test	0.6	0.8	1.3	0.9	-1.1	-0.9	1.1	0.6	0.5
Total locomotion distance, NPP test	0.2	0.3	0.7	-0.2	0.4	0.7	0.3	-0.6	-0.8
Locomotion velocity, NPP test	0.3	0.4	0.7	-0.3	0.5	0.8	0.2	-0.7	-0.9
Intraocular pressure	0.7	1.0	1.8	0.0	1.2	1.2	-0.1	-1.4	-1.1
Delta distance traveled before/after self-admin	1.5	1.6	4.8	-1.8	0.8	1.0	-2.2	-0.2	-0.1
Delta ambulatory time before/after self-admin	0.8	0.9	2.7	-1.3	0.5	0.7	-1.6	-0.1	-0.0
Parametrial fat weight	0.1	0.2	0.4	-0.4	-0.5	-0.2	-0.6	0.3	0.5
Pavlov. Cond. lever latency	1.5	1.9	2.8	1.2	-1.5	-1.7	1.2	1.3	1.3
Pavlov. Cond. magazine entry latency	0.1	0.2	0.6	0.8	-0.4	-0.2	0.2	0.1	0.3
Pavlov. Cond. change in total contacts	0.8	0.8	1.9	0.2	1.0	1.0	-0.3	-1.4	-1.0
Pavlov. Cond. index score	0.2	0.2	0.5	-0.0	0.5	0.6	-0.5	-0.7	-0.4
Pavlov. Cond. latency score	0.4	0.5	0.7	-0.3	0.7	0.8	-0.7	-0.8	-0.6
Pavlov. Cond. lever contacts	2.2	2.6	3.9	-1.3	1.7	2.0	-1.6	-1.6	-1.5
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	-0.6	0.0	-0.1	-0.2	0.4	0.0
Pavlov. Cond. intertrial magazine entries	2.0	2.5	3.3	-1.4	1.8	1.7	-1.1	-1.6	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.5	0.1	0.4	0.6	-0.4	-0.7	-0.4
Pavlov. Cond. response bias	0.4	0.5	0.8	-0.3	0.7	0.9	-0.6	-0.8	-0.6
Pavlov. Cond. lever latency	1.1	1.4	2.7	1.5	-1.0	-1.1	1.6	1.1	0.6
Pavlov. Cond. magazine entry latency	0.4	0.5	1.1	-0.7	0.6	0.6	-1.1	-0.7	-0.3
Pavlov. Cond. change in total contacts	0.8	1.1	2.4	-0.6	1.3	1.0	-0.6	-1.5	-1.1
Pavlov. Cond. index score	1.0	1.3	1.7	-1.3	1.1	1.1	-1.3	-1.2	-0.7
Pavlov. Cond. latency score	1.2	1.5	2.3	-1.5	1.1	1.1	-1.5	-1.2	-0.7
Pavlov. Cond. lever contacts	1.0	1.4	2.1	-1.4	1.0	1.2	-1.4	-1.0	-0.7
Pavlov. Cond. magazine entry number	0.7	0.9	1.2	0.9	-0.9	-0.9	1.1	1.1	0.6
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.7	-0.1	-0.9	-0.7	0.3	1.3	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	1.5	-1.2	1.0	1.0	-1.2	-1.1	-0.7
Pavlov. Cond. response bias	0.6	0.8	1.0	-0.9	0.9	0.9	-1.0	-1.0	-0.6
Time in closed arm before self-admin	1.9	2.2	4.1	0.8	1.5	1.2	1.0	-1.9	-2.0
Time in closed arm after self-admin	2.0	2.0	3.6	-0.3	1.6	1.5	0.1	-1.9	-1.9
Time in open arm before self-admin	1.3	1.4	2.9	0.1	-1.5	-1.1	-0.2	1.5	1.7
Time in open arm after self-admin	0.3	0.3	0.5	-0.2	-0.5	-0.6	-0.2	0.7	0.7
Bone: periosteal estimation	1.3	2.8	4.4	-1.0	2.1	1.8	-0.7	-2.1	-1.8
Bone: periosteal perimeter	3.4	5.6	9.7	-1.2	2.9	2.6	-0.9	-3.1	-2.5
Bone: post-yield work	1.0	1.3	2.0	1.0	-1.3	-1.4	0.7	1.1	1.3
Progressive ratio test 1 active lever presses	1.0	1.1	1.9	-0.3	-1.2	-0.9	-0.6	1.4	1.4
Progressive ratio test 1 breakpoint	0.9	1.0	1.7	-0.4	-1.1	-0.8	-0.7	1.3	1.3
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.3	-0.5	-0.3	-0.2	-0.6	0.5	0.5
Progressive ratio test 2 active lever presses	0.3	0.3	0.6	-0.8	0.4	0.6	-0.7	-0.3	-0.3
Progressive ratio test 2 breakpoint	0.2	0.3	0.4	-0.7	0.4	0.6	-0.7	-0.3	-0.4
Progressive ratio test 2 inactive lever presses	0.4	0.4	0.7	-0.9	0.5	0.8	-0.8	-0.5	-0.5
Incentive Sensitization - Responses	1.1	1.1	1.5	-0.8	1.1	1.2	-0.6	-1.1	-1.2
Incentive Sensitization - Breakpoint	0.9	0.9	1.3	-0.7	1.0	1.1	-0.6	-1.0	-1.1
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.4	-0.4	0.7	0.7	-0.6	-0.5	-0.5
Progressive ratio	0.1	0.2	0.5	-0.5	-0.1	0.2	-0.7	0.3	0.3
Food seeking constrained by brief footshock	2.6	3.2	5.1	-2.3	1.7	2.0	-1.9	-1.3	-1.3
Seeking ratio, punishment vs. effort	0.4	0.4	0.8	-0.4	0.7	0.7	0.0	-0.8	-0.9
Retroperitoneal fat weight	1.4	4.7	6.7	-2.3	2.2	2.6	-1.9	-1.7	-2.1
Reaction time number correct	0.4	0.6	1.0	1.0	-0.7	-0.9	0.8	0.4	0.5
Reaction time mean minus median	0.2	0.2	0.4	-0.2	0.5	0.6	-0.2	-0.5	-0.5
Reaction time mean minus median AUC	0.1	0.1	0.1	-0.3	0.4	0.3	-0.2	-0.2	-0.3
Reaction time num false alarms	0.0	0.1	0.3	0.5	0.1	0.0	0.3	-0.1	-0.1
Reaction time num false alarms AUC	0.1	0.1	0.2	0.5	-0.3	-0.3	0.1	0.5	0.3
Reaction time trials correct on left	0.4	0.6	1.0	1.0	-0.7	-0.9	0.8	0.4	0.5
Reaction time trials on left	0.4	0.6	1.1	1.1	-0.7	-0.9	0.8	0.5	0.6
Reaction time mean	1.1	1.5	2.5	0.7	-1.5	-1.3	0.1	1.5	1.6
Reaction time mean AUC	1.1	1.5	2.4	0.8	-1.5	-1.3	0.3	1.4	1.6
Median of all reaction times	2.4	3.4	5.2	0.9	-2.2	-2.0	0.1	2.3	2.3
Reaction time omissions	1.1	1.6	2.1	1.4	-1.4	-1.2	1.0	1.2	1.2
Reaction time false alarm rate	0.0	0.0	0.0	0.0	0.2	0.2	-0.2	-0.0	-0.1
Reaction time premature initiation rate	5.9	7.9	10.7	-2.3	3.1	3.3	-1.7	-3.2	-3.0
Reaction time premature initiations	2.7	3.9	5.9	-1.4	2.2	2.2	-1.1	-2.4	-2.1
Std. dev. reaction times	0.1	0.1	0.2	-0.1	-0.3	-0.1	-0.3	0.3	0.4
Reaction time trials completed	0.4	0.6	1.1	1.1	-0.7	-0.9	0.8	0.5	0.6
Reaction time trials AUC	0.3	0.4	0.7	0.8	-0.6	-0.8	0.6	0.3	0.5
Run reversals in cocaine runway, females	0.2	0.2	0.4	0.2	-0.3	-0.4	0.1	0.6	0.6
Run reversals in cocaine runway, males	0.4	0.4	1.1	1.0	-0.1	-0.1	1.1	-0.2	-0.2
Latency to leave start box in cocaine runway	0.8	0.9	2.1	-1.4	0.5	0.9	-1.4	-0.4	-0.3
Latency to leave start box in cocaine runway, F	1.2	1.3	2.8	-1.2	-0.7	-0.2	-1.7	1.1	1.2
Latency to leave start box in cocaine runway, M	1.3	1.3	2.4	-0.4	1.1	1.2	0.1	-1.5	-1.5
Std. dev. time between licks in bursts	2.0	2.4	3.7	-1.5	1.9	1.8	-0.8	-1.5	-1.5
Total sessions with >9 infusions	0.2	0.3	0.6	-0.8	0.1	0.6	-0.7	-0.2	-0.2
Short access day 1 total inactive lever presses	1.7	1.9	5.7	-2.1	0.4	0.8	-2.4	0.4	0.4
Short access day 10 total inactive lever presses	8.5	9.4	13.7	-3.7	3.4	3.2	-3.1	-2.4	-2.4
Short access day 1 total infusions	0.4	0.4	0.9	-0.8	-0.4	0.0	-0.9	0.6	0.5
Short access day 10 total infusions	0.4	0.5	1.4	-1.1	0.2	0.4	-1.2	0.1	0.1
Short access total infusions	0.2	0.3	0.7	-0.7	-0.3	0.1	-0.8	0.4	0.4
Short access day 1 locomotion	0.4	0.4	0.9	-0.8	-0.4	-0.1	-1.0	0.6	0.5
Short access day 10 total locomotion	1.6	1.7	4.6	-2.1	0.7	1.0	-2.2	-0.1	-0.1
Short access total locomotion	0.5	0.5	1.4	-1.1	0.1	0.4	-1.2	0.1	0.2
One hour access (0.3 mA shock)	1.0	1.2	1.6	-0.9	1.2	1.1	-0.5	-1.3	-1.3
Compulsive drug intake	0.3	0.3	0.7	0.8	-0.1	-0.3	0.9	-0.2	-0.2
One hour access (shock baseline)	1.4	1.6	2.2	-1.4	1.5	1.4	-1.0	-1.2	-1.2
Social response proportion	0.1	0.1	0.3	0.6	0.0	-0.0	0.3	-0.5	-0.2
Social responses	0.2	0.3	0.7	0.4	0.4	0.4	0.2	-0.8	-0.6
Social time	0.5	0.6	1.3	-0.4	-0.9	-0.6	-0.7	0.7	1.1
Soleus weight	0.5	1.5	3.0	-1.7	1.0	1.1	-1.7	-0.7	-0.6
Bone: stiffness	0.2	0.2	0.4	0.5	-0.4	-0.6	0.3	0.3	0.6
Tibialis anterior weight	0.0	0.0	0.1	-0.1	0.0	0.1	-0.4	0.1	0.1
Time to tail flick, vehicle, before self-admin	1.2	1.2	1.7	-1.2	1.2	1.3	-1.1	-1.0	-0.9
Time to tail flick, vehicle, after self-admin	1.3	1.4	1.8	-1.2	1.2	1.3	-1.1	-1.2	-1.2
Time to tail flick, test, before self-admin	0.4	0.4	1.1	-0.8	0.6	0.5	-1.1	-0.2	-0.2
Time to tail flick, test, after self-admin	1.3	1.4	2.4	-1.5	1.1	1.2	-1.5	-0.6	-0.7
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.7	0.9	-0.6	-0.6	0.8	0.3	0.2
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	-0.3	0.1	0.3	-0.1	-0.1	-0.1
Tibia length	1.0	2.9	4.0	1.8	-1.8	-2.0	1.9	1.1	1.5
Ambulatory time before self-admin	0.9	1.0	1.5	0.7	-1.2	-1.1	0.4	1.1	1.2
Ambulatory time after self-admin	0.3	0.3	0.8	-0.3	-0.2	-0.4	-0.7	0.6	0.9
Bone: tissue strength	1.7	1.6	3.2	0.8	-1.4	-1.2	1.2	1.8	1.0
Total heroin consumption	0.4	0.4	0.5	-0.6	0.7	0.7	-0.6	-0.6	-0.6
Bone: trabecular number	0.3	0.5	1.3	1.1	-0.4	-0.2	1.1	0.3	-0.1
Bone: trabecular spacing	1.0	1.3	3.1	-1.8	0.9	1.0	-1.6	-0.5	-0.5
Bone: trabecular thickness	0.8	1.0	2.3	0.1	1.1	0.9	0.2	-1.5	-1.2
Bone: trabecular tissue density	1.4	2.0	2.9	1.7	-1.4	-1.6	1.4	1.0	1.2
Water consumed over 24 hours	0.2	0.3	1.0	-1.0	0.2	0.4	-0.6	-0.3	-0.1
Number of responses in last shaping day	0.2	0.2	0.3	0.0	-0.6	-0.3	-0.1	0.5	0.5