LOC102547518

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	intron excision ratio	chr9_44943995_45025905	0.02	0.01	8.1e-03	0.01	0.01	0.01	0.01	6.0e-03	8.1e-03	2.0e-02	3.3e-02
2	NAcc	intron excision ratio	chr9_44944938_44945016	0.03	0.02	1.3e-03	0	0.02	0.01	0.01	7.5e-02	4.0e-03	4.0e-02	4.2e-02
3	Brain	intron excision ratio	chr9_44944938_44945021	0.06	0.04	4.0e-06	0.03	0.05	0.05	0.04	2.1e-03	1.2e-05	2.8e-05	4.6e-05
4	BLA	mRNA stability	LOC102547518	0.16	0.09	1.3e-04	0.03	0.05	0.05	0.05	1.4e-02	1.1e-03	8.7e-04	9.1e-04
5	pVTA	intron excision ratio	chr9_44944938_44945016	0.15	0.12	8.2e-03	0.05	0.03	-0	0.05	4.6e-03	1.8e-02	6.3e-01	2.3e-03
6	Brain	mRNA stability	LOC102547518	0.35	0.14	2.0e-11	0.12	0.13	0.12	0.12	3.1e-11	8.3e-12	2.1e-11	3.0e-11
7	PL	gene expression	LOC102547518	0.06	0.04	4.4e-04	0.03	0.03	0.03	0.02	1.9e-04	5.8e-04	6.6e-04	9.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	2.6	4.4	10.9	3.3	2.7	2.6	1.2	1.2	-0.6	1.6
Area under the delay curve	3.0	3.2	4.6	-0.9	-1.5	-1.6	-1.8	-2.2	2.0	-2.1
BMI with tail	0.6	1.9	5.3	-2.3	-1.8	-1.8	-0.2	-1.0	-0.1	-0.7
BMI without tail	0.0	0.0	0.2	0.5	0.0	0.1	-0.3	0.0	-0.1	-0.2
Body weight	0.0	0.1	0.2	0.2	0.3	0.2	-0.1	-0.0	-0.4	0.3
Weight adjusted by age	1.1	1.2	4.1	-0.7	0.4	0.3	2.0	0.2	-1.4	1.3
Bone surface	0.7	1.3	2.4	1.5	1.0	1.1	1.3	1.0	-0.8	0.9
Bone volume	1.6	2.7	6.6	2.6	1.9	1.9	1.3	1.3	-0.7	1.2
Breakpoint value in progressive ratio session	0.4	0.4	1.0	1.0	0.6	0.2	-0.7	0.2	1.0	-0.4
Number of licking bursts	0.1	0.2	0.5	0.2	-0.4	-0.3	-0.3	-0.3	0.4	-0.7
Context. condit. distance diff. score	1.0	1.2	2.5	1.6	1.5	1.5	0.1	-0.3	-0.5	1.0
Locomotion velocity, session 1	0.4	0.4	1.6	-0.1	-0.1	-0.1	-0.9	-1.3	0.5	-0.3
Locomotion distance, session 1	0.3	0.4	1.2	-1.1	-0.2	-0.3	-0.4	-1.1	-0.2	0.5
Locomotion velocity, session 2	1.0	1.2	3.2	-1.8	-1.4	-1.4	0.3	-0.8	-0.3	-0.2
Locomotion distance, session 2	0.9	1.3	3.4	-1.9	-1.5	-1.5	-0.3	-0.7	0.1	-0.6
Locomotion velocity, session 3	0.3	0.3	0.6	0.6	0.7	0.6	0.4	0.2	-0.4	0.8
Locomotion distance, session 3	0.1	0.1	0.2	0.4	0.4	0.3	0.0	0.3	0.0	0.3
Stereotopy head waving bouts, day 3	0.1	0.1	0.3	0.6	0.2	0.2	-0.3	0.1	0.5	-0.2
Stereotopy head waving duration, day 3	0.2	0.3	0.9	0.2	-0.2	-0.2	-0.9	-0.5	0.8	-0.5
Locomotion velocity, session 7	0.8	0.9	1.9	-0.9	-0.1	0.0	1.4	-0.5	-1.4	1.2
Locomotion distance, session 7	0.3	0.4	0.9	-0.9	-0.7	-0.6	0.4	-0.9	-0.5	-0.0
Stereotopy head waving bouts, day 7	0.2	0.2	0.6	0.5	0.2	0.1	-0.6	-0.5	0.8	0.2
Stereotopy head waving duration, day 7	0.4	0.4	1.0	0.8	0.9	0.8	0.0	-0.1	-0.2	1.0
Locomotion velocity, session 8	1.3	1.5	3.2	0.4	1.2	1.2	1.5	-0.1	-1.4	1.8
Locomotion distance, session 8	0.4	0.6	1.4	-0.0	0.6	0.6	0.8	-0.3	-1.2	1.2
Degree of sensitization distance	1.4	1.4	2.8	-1.4	-1.4	-1.3	-0.4	-1.7	0.3	-1.0
Degree of sensitization stereotypy	0.2	0.3	0.6	0.6	0.7	0.6	0.1	-0.2	0.1	0.8
Conditioned locomotion	0.4	0.5	1.1	1.0	0.6	0.5	-0.8	-0.2	1.1	-0.2
Cocaine response after cond. corrected	1.2	1.4	2.9	-0.7	-1.3	-1.3	-1.1	-0.9	0.9	-1.7
Cocaine response after cond. not corrected	0.7	0.7	1.4	-0.6	-0.9	-0.9	-0.8	-0.9	0.6	-1.2
Cocaine response before conditioning	0.5	0.6	2.1	0.2	0.9	0.7	0.7	-0.1	-0.7	1.4
Saline control response	0.4	0.5	1.6	0.1	0.5	0.6	0.5	0.1	-1.0	1.3
Bone: connectivity density	0.6	1.0	3.2	1.8	1.1	1.1	0.8	0.6	-0.2	0.7
Bone: cortical apparent density	1.0	1.4	3.2	-1.8	-0.5	-0.5	1.4	0.3	-1.6	1.1
Bone: cortical area	0.1	0.2	0.4	0.4	0.4	0.3	0.7	0.2	-0.3	0.7
Bone: cortical porosity	0.5	0.5	1.7	1.3	0.8	0.8	0.2	0.7	-0.2	0.3
Bone: cortical porosity	0.9	1.0	2.5	1.6	1.2	1.3	0.5	0.6	-0.7	0.8
Bone: cortical thickness	0.1	0.2	0.5	0.4	0.4	0.4	0.7	0.0	-0.4	0.7
Bone: cortical thickness	0.1	0.1	0.2	0.4	0.4	0.4	0.2	-0.4	-0.3	0.3
Bone: cortical tissue density	1.1	1.4	3.1	-1.8	-0.5	-0.5	1.5	0.3	-1.6	1.1
Condit. Reinf. active minus inactive responses	3.3	3.7	10.9	-0.6	-0.9	-1.0	-2.5	-3.3	2.3	-1.2
Condit. Reinf. active-inactive response ratio	3.5	3.8	12.8	-0.4	-0.6	-0.7	-2.6	-3.6	2.2	-1.1
Condit. Reinf. active responses	1.5	1.8	6.2	-0.4	-0.6	-0.7	-1.7	-2.5	1.5	-0.8
Condit. Reinf. inactive responses	0.1	0.2	0.5	-0.7	-0.5	-0.6	0.0	-0.1	-0.1	-0.1
Incentive salience index mean	1.0	1.2	5.0	-0.0	-0.1	-0.2	-1.3	-2.2	1.2	-0.5
Condit. Reinf. lever presses	0.6	0.8	1.4	0.9	1.2	1.2	0.6	-0.0	-0.7	1.0
Condit. Reinf. active minus inactive responses	1.2	1.5	3.9	0.3	-0.2	-0.3	-1.6	-2.0	1.8	-0.8
Condit. Reinf. active-inactive response ratio	0.8	0.9	2.2	0.9	0.6	0.4	-1.0	-1.3	1.5	-0.4
Condit. Reinf. active responses	0.9	1.2	3.0	-0.2	-0.7	-0.8	-1.2	-1.7	1.3	-1.0
Condit. Reinf. inactive responses	0.3	0.4	0.7	-0.8	-0.8	-0.7	0.4	-0.0	-0.7	-0.2
Condit. Reinf. lever presses	0.2	0.2	0.8	0.4	0.1	0.1	-0.3	-0.9	0.7	-0.1
Condit. Reinf. lever reinforcers received	1.2	1.7	3.9	-0.5	-1.0	-1.0	-1.4	-2.0	1.5	-1.2
Conditioned reinforcement - actives	1.0	1.0	2.1	-0.3	-0.6	-0.7	-1.1	-1.5	1.4	-1.0
Conditioned reinforcement - inactives	0.3	0.3	0.7	0.2	0.6	0.2	-0.6	-0.7	0.8	0.0
Conditioned locomotion	0.2	0.3	1.4	-0.4	-0.2	-0.4	0.1	-1.2	0.4	-0.0
Patch foraging indifference point 0 sec	0.9	1.4	4.5	-0.2	0.3	0.3	2.1	1.1	-1.5	1.3
Patch foraging indifference point AUC	0.6	0.7	1.4	-1.2	-0.9	-1.0	-0.6	-0.6	0.9	-0.6
Delay disc. indifference point, 0s delay	0.3	0.4	0.9	-0.5	-0.1	-0.0	0.9	-0.5	-0.9	0.5
Delay disc. indifference point, 16s delay	2.0	2.0	4.0	0.2	-0.7	-0.7	-1.6	-2.0	1.8	-1.8
Delay disc. indifference point, 2s delay	0.9	1.0	1.7	-0.6	-0.9	-1.1	-0.4	-1.0	1.2	-1.3
Delay disc. indifference point, 24s delay	0.4	0.4	1.5	-0.1	-0.3	-0.3	-0.7	-1.2	0.6	-0.6
Delay disc. indifference point, 4s delay	0.5	0.5	1.2	-0.8	-0.7	-0.7	-0.6	-1.1	0.3	-0.6
Delay disc. indifference point, 8s delay	1.6	1.7	2.7	-0.8	-1.2	-1.2	-1.3	-1.4	1.4	-1.7
Indifference point function ln k	0.4	0.6	1.2	-0.7	-1.1	-0.8	0.7	0.2	-0.9	-0.4
Indifference point function log k	0.4	0.6	1.2	-0.7	-1.1	-0.8	0.7	0.2	-0.9	-0.4
Patch foraging total patch changes 0 sec	0.5	0.9	3.2	-0.4	-0.1	-0.1	1.8	0.9	-1.1	0.9
Patch foraging total patch changes 12 sec	1.2	1.5	3.2	0.4	1.2	1.0	1.8	1.0	-1.1	1.6
Patch foraging total patch changes 18 sec	0.4	0.6	1.5	-1.2	-1.0	-1.1	0.3	-0.0	0.5	-0.3
Patch foraging total patch changes 24 sec	0.6	0.7	1.8	-0.4	0.5	0.4	1.3	0.9	-0.9	1.0
Patch foraging total patch changes 6 sec	0.3	0.4	1.5	-0.4	0.1	0.1	1.2	0.7	-0.5	0.8
Patch foraging time to switch 0 sec	0.7	1.1	1.9	0.9	1.2	1.1	0.7	1.4	-0.8	0.9
Patch foraging water rate 0 sec	1.0	1.6	2.8	-0.8	-1.3	-1.3	-1.1	-1.7	1.4	-1.1
Patch foraging water rate 12 sec	0.4	0.6	1.3	-0.8	-1.1	-1.0	-0.1	-0.3	0.6	-0.9
Patch foraging water rate 18 sec	0.0	0.0	0.1	0.2	-0.2	-0.3	0.0	0.1	0.3	-0.1
Patch foraging water rate 24 sec	0.2	0.2	0.5	-0.4	-0.7	-0.6	-0.4	-0.3	0.1	-0.6
Patch foraging water rate 6 sec	0.7	1.0	2.3	-1.1	-1.5	-1.3	-0.5	0.1	0.6	-1.2
Seeking ratio, delayed vs. immediate footshock	0.6	0.6	1.7	1.1	1.3	1.1	-0.1	-0.3	0.2	0.5
Distance traveled before self-admin	0.6	0.7	1.3	0.5	0.8	0.8	0.9	1.2	-0.8	0.4
Distance traveled after self-admin	4.2	4.6	7.2	2.0	2.7	2.5	2.1	2.0	-1.6	2.1
Extensor digitorum longus weight	2.2	8.6	29.6	-5.4	-3.8	-3.7	0.1	-0.4	-1.3	-0.8
Bone: elastic displacement	0.2	0.3	0.8	0.5	-0.3	-0.3	-0.1	0.4	0.7	-0.9
Bone: elastic work	0.3	0.3	1.3	1.2	0.7	0.7	0.2	0.2	0.1	0.1
Bone: endosteal estimation	0.0	0.0	0.1	0.3	0.1	0.1	0.2	0.2	-0.1	-0.1
Bone: endosteal perimeter	0.0	0.0	0.1	0.2	0.1	0.1	-0.2	0.1	0.3	-0.0
Epididymis fat weight	0.0	0.0	0.1	-0.1	-0.1	-0.3	-0.1	0.2	0.1	-0.3
Delta time in closed arm before/after self-admin	0.1	0.1	0.7	0.1	-0.0	-0.2	0.9	0.5	0.1	-0.1
Delta time in open arm before/after self-admin	0.2	0.1	0.3	0.6	0.3	0.6	0.1	0.1	-0.5	0.2
Diff in mean of infusions in LGA sessions	0.4	0.4	1.2	1.1	0.5	0.4	-0.4	0.5	0.8	-0.5
Delay discount exponential model param	3.0	3.1	4.7	0.9	1.5	1.5	1.9	2.1	-2.0	2.2
Extinction: sum of active levers before priming	0.7	0.7	2.2	1.5	1.0	0.8	-0.4	0.4	0.8	-0.4
Active lever presses in extinction session 6	2.7	2.6	4.5	-0.9	-1.2	-1.5	-2.0	-1.1	2.1	-2.0
Bone: final force	0.4	0.7	1.6	0.4	0.8	0.8	0.8	0.3	-1.0	1.3
Bone: final moment	0.3	0.5	1.3	0.4	0.6	0.6	0.7	0.2	-1.0	1.1
Food consumed during 24 hour testing period	0.4	0.5	1.0	-0.8	-0.6	-0.7	-0.4	-1.0	0.4	-0.5
Glucose	0.1	0.2	0.6	0.2	-0.2	-0.2	-0.3	0.4	0.7	-0.8
Heart weight	0.4	0.6	1.2	-1.1	-1.0	-1.0	0.2	-0.3	0.2	-1.0
Delay discount hyperbolic model param	2.9	3.1	4.3	1.2	1.6	1.6	1.8	2.0	-1.8	2.1
Intermittent access intake day 1-15 change	0.1	0.1	0.3	0.3	0.2	0.3	0.3	-0.0	-0.5	0.3
Intermittent access intake escalation	0.2	0.2	0.5	0.7	0.6	0.6	-0.1	-0.5	-0.2	0.4
Intermittent access intake escalation 2	0.2	0.2	0.4	0.5	0.5	0.4	-0.5	-0.6	0.2	0.1
Intermitt. access day 1 inactive lever presses	0.9	1.0	1.8	1.0	1.3	1.2	0.6	1.1	-0.6	0.8
Intermitt. access day 15 inactive lever presses	0.5	0.6	1.0	0.3	0.8	0.7	1.0	0.6	-0.7	1.0
Intermitt. access escalation Index	0.3	0.3	1.1	-0.0	0.1	0.1	-1.1	-0.8	0.4	0.2
Intermittent access day 1 total infusions	1.9	2.2	5.5	-0.0	-0.7	-1.0	-1.7	-1.4	2.4	-1.9
Intermittent access day 15 total infusions	0.9	1.0	2.2	0.4	-0.1	-0.4	-1.3	-1.0	1.5	-1.2
Intermittent access terminal intake (last 3 days)	1.0	1.1	2.7	0.1	-0.3	-0.7	-1.2	-1.0	1.6	-1.3
Intermittent access total infusions	1.3	1.5	3.5	0.2	-0.5	-0.8	-1.4	-1.0	1.9	-1.7
Intermittent access day 1 locomotion	0.1	0.1	0.3	0.0	0.1	-0.1	-0.1	-0.3	0.5	-0.5
Intermittent access day 15 total locomotion	0.2	0.2	0.6	-0.3	-0.2	-0.3	-0.3	-0.8	0.4	-0.2
Intermittent access total locomotion	0.2	0.2	0.5	-0.2	-0.3	-0.4	-0.2	-0.7	0.4	-0.5
Intermittent access standard deviation	0.7	0.8	2.4	1.5	1.0	0.7	-0.6	0.0	1.0	-0.4
Left kidney weight	0.2	0.6	1.5	-0.0	0.4	0.2	1.2	1.2	-0.8	0.5
Right kidney weight	1.4	4.0	5.5	0.9	1.9	1.7	2.3	2.2	-2.3	2.2
Cocaine induced anxiety	0.6	0.7	2.4	-1.6	-0.3	-0.5	0.5	0.4	-0.8	1.1
Post-drug Anxiety	0.9	0.9	1.8	-1.2	-0.7	-0.9	-1.3	-1.1	1.1	-0.0
Baseline Anxiety	2.0	2.1	5.2	0.5	-0.4	-0.5	-2.1	-1.5	2.3	-1.6
Tail length	0.3	1.0	3.5	1.9	1.1	1.0	-0.9	0.1	0.5	-0.1
Length with tail	0.2	0.9	2.0	1.4	1.4	1.2	0.0	0.6	-0.3	0.7
Length without tail	0.2	0.5	1.1	-0.8	0.1	-0.0	1.0	0.4	-1.1	1.0
Times rat made contact with spout	0.9	1.0	2.0	0.6	-0.5	-0.5	-1.4	-0.3	1.4	-1.4
Lifetime Intake	1.3	1.5	3.2	-0.0	-0.7	-1.0	-1.3	-1.2	1.8	-1.7
Liver weight, left	0.6	1.0	2.2	0.9	0.7	0.7	1.5	1.3	-0.9	0.5
Liver weight, right	0.1	0.1	0.3	0.5	0.4	0.4	0.1	0.2	0.3	0.1
Locomotor activity	0.1	0.2	0.5	0.5	0.2	0.0	-0.5	0.2	0.7	-0.4
Locomotor testing distance	0.5	0.8	2.5	1.6	1.1	1.1	0.2	0.7	0.1	0.3
Locomotor testing rearing	1.1	1.6	3.9	2.0	1.6	1.6	0.3	0.7	-0.7	1.1
Locomotion in novel chamber	1.9	2.3	6.7	-2.6	-1.9	-2.0	-0.8	-1.0	0.4	-0.4
Locomotion in novel chamber post-restriction	0.7	0.8	3.0	-1.7	-1.1	-1.1	-0.3	-0.3	0.2	-0.1
Fecal boli incidents, locomotor time 1	1.3	1.4	2.7	-1.6	-1.6	-1.4	-0.6	-1.0	0.1	-1.1
Change in fecal boli incidents, locomotor task	0.5	0.5	1.2	1.1	0.7	0.6	0.8	0.5	-0.5	0.3
Time >=10cm from walls, locomotor time 1	1.8	1.8	5.1	-2.3	-2.0	-1.7	0.3	-0.2	-0.6	-0.5
Bouts of movement, locomotor time 1	8.5	9.2	13.0	-2.9	-3.6	-3.4	-2.9	-3.1	2.5	-2.7
Total resting periods, locomotor time 1	7.3	8.0	11.7	-2.9	-3.4	-3.2	-2.5	-3.0	2.2	-2.3
Rest time, locomotor task time 1	2.4	2.7	4.1	-0.5	-1.3	-1.3	-1.8	-2.0	2.0	-2.0
Distance moved, locomotor task time 1	0.1	0.1	0.3	-0.3	-0.0	-0.2	0.5	0.3	-0.1	0.3
Vertical activity count, locomotor time 1	1.1	1.2	2.2	1.0	1.2	1.2	0.9	0.7	-1.0	1.5
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.2	-0.3	-0.2	0.2	-0.1	-0.0	-0.4
Bouts of movement, locomotor time 2	1.9	2.1	4.2	-1.6	-1.3	-1.4	-1.3	-2.0	1.4	-0.7
Total resting periods, locomotor time 2	1.6	1.7	3.3	-1.4	-1.2	-1.3	-1.1	-1.8	1.3	-0.6
Rest time, locomotor task time 2	0.1	0.1	0.4	0.3	-0.2	-0.1	-0.3	-0.2	0.6	-0.2
Distance moved, locomotor task time 2	0.6	0.6	1.2	-0.9	-1.0	-1.1	-0.1	-0.9	0.4	-0.7
Vertical activity count, locomotor time 2	0.3	0.3	1.5	-0.4	0.0	0.1	-0.3	-1.2	-0.3	0.5
Light reinforcement 1	0.6	1.2	3.7	-1.9	-1.1	-1.2	0.8	0.6	-0.9	-0.0
Light reinforcement 2	0.4	0.5	1.1	-0.8	-0.5	-0.7	1.0	0.8	-0.1	-0.4
Bone: marrow area	0.0	0.0	0.1	0.3	0.1	0.1	0.2	0.2	-0.1	-0.1
Bone: maximum diameter	0.2	0.4	0.7	0.8	0.6	0.5	0.5	0.8	-0.2	0.5
Bone: maximum force	0.3	0.5	1.1	0.5	0.7	0.7	0.8	0.3	-0.9	1.1
Bone: maximum moment	0.3	0.4	0.9	0.4	0.5	0.5	0.8	0.3	-0.9	0.9
Mean time between licks in bursts	1.2	1.6	4.1	-1.4	-0.7	-0.7	1.5	2.0	-1.5	0.2
Mean num. licks in bursts	0.1	0.1	0.2	-0.3	-0.2	-0.4	-0.5	-0.1	0.4	-0.3
Cd content in liver	0.3	0.4	0.6	0.6	0.8	0.8	0.5	0.1	-0.6	0.7
Co content in liver	0.5	0.5	1.5	0.5	0.4	0.4	-1.2	-1.1	0.5	0.3
Cu content in liver	0.6	0.8	2.3	0.7	0.6	0.5	-1.2	-1.5	0.8	-0.0
Fe content in liver	2.1	2.5	5.1	2.3	2.1	2.1	0.7	1.1	-0.6	1.3
K content in liver	0.6	0.5	1.2	-0.6	-0.3	-0.2	1.1	1.1	-0.8	0.6
Mg content in liver	0.5	0.6	1.3	0.0	0.2	0.3	1.0	1.1	-0.9	0.8
Mn content in liver	0.2	0.2	0.7	-0.8	-0.2	-0.1	0.3	0.5	-0.6	0.5
Na content in liver	3.0	3.1	5.5	1.2	1.3	1.6	2.4	1.9	-2.2	1.5
Rb content in liver	1.6	2.0	3.6	-1.9	-1.4	-1.5	-1.4	-1.6	1.1	-0.5
Se content in liver	0.0	0.0	0.1	-0.2	-0.1	-0.2	0.1	-0.1	0.1	-0.1
Sr content in liver	0.7	0.6	1.3	-0.6	-1.0	-1.0	-0.7	0.4	0.3	-1.2
Zn content in liver	0.1	0.1	0.3	0.0	0.0	-0.1	-0.4	-0.5	0.3	0.2
Bone: minimum diameter	0.1	0.2	0.6	-0.2	0.0	0.1	0.8	0.2	-0.7	0.6
Time in familiar zone, hab. session 1	1.3	1.2	3.3	0.5	-0.4	-0.5	-1.8	-0.6	1.6	-1.2
Time in novel zone, hab. session 1	0.1	0.1	0.3	0.4	0.4	0.4	0.6	0.3	-0.1	0.1
Total zone transitions, hab. session 1	1.4	1.9	3.8	0.2	1.1	1.1	1.9	0.6	-1.7	1.9
Total locomotion distance, hab. session 1	0.2	0.3	0.8	-0.9	-0.4	-0.5	0.6	-0.6	-0.3	0.3
Locomotion velocity, hab. session 1	0.3	0.5	1.3	-0.7	-0.1	-0.1	1.2	0.1	-0.9	0.7
Time in familiar zone, hab. session 2	0.2	0.2	0.7	0.5	0.2	0.2	0.2	0.8	0.2	-0.1
Time in novel zone, hab. session 2	0.2	0.2	0.8	0.1	0.1	0.1	-0.6	-0.9	0.2	0.0
Total zone transitions, hab. session 2	0.0	0.1	0.2	-0.5	-0.2	-0.3	-0.2	-0.1	0.0	-0.0
Total locomotion distance, hab. session 2	1.5	2.0	2.7	-1.6	-1.5	-1.6	-1.4	-1.3	1.1	-1.3
Locomotion velocity, hab. session 2	0.9	1.3	2.2	-1.5	-1.3	-1.3	-1.0	-1.0	0.6	-0.9
Novel to familiar place preference ratio	1.4	1.5	2.8	0.0	-1.0	-0.9	-1.4	-1.1	1.6	-1.7
Novelty place preference	1.4	1.4	2.5	0.1	-0.9	-0.9	-1.4	-1.1	1.5	-1.6
Time in novel zone, NPP test	1.4	1.4	2.8	0.2	-0.8	-0.8	-1.4	-1.0	1.7	-1.6
Total zone transitions, NPP test	0.2	0.2	0.8	-0.8	-0.2	-0.3	-0.3	-0.9	-0.1	0.2
Total locomotion distance, NPP test	0.7	0.9	1.4	-1.2	-1.1	-1.1	-0.7	-1.2	0.5	-0.6
Locomotion velocity, NPP test	0.5	0.7	2.0	-1.4	-1.1	-1.1	-0.3	-0.8	0.0	-0.3
Intraocular pressure	0.9	1.2	2.6	-1.6	-1.3	-1.3	-0.9	-0.7	0.4	-0.9
Delta distance traveled before/after self-admin	0.9	1.0	1.6	0.7	1.1	1.0	1.1	0.8	-0.8	1.3
Delta ambulatory time before/after self-admin	0.6	0.6	1.1	0.4	0.9	0.7	1.0	0.7	-0.6	1.0
Parametrial fat weight	0.0	0.1	0.4	0.2	0.1	0.2	0.2	0.6	-0.3	-0.2
Pavlov. Cond. lever latency	0.8	1.0	1.9	-1.1	-1.4	-1.4	-0.5	0.3	0.7	-1.0
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	0.2	0.3	0.3	-0.3	-0.3	0.2	0.0
Pavlov. Cond. change in total contacts	0.3	0.4	1.9	-0.1	-0.2	-0.2	-0.5	-1.4	0.4	-0.4
Pavlov. Cond. index score	0.2	0.3	0.7	0.8	0.7	0.7	-0.2	-0.4	0.1	0.0
Pavlov. Cond. latency score	0.3	0.4	1.0	1.0	0.9	0.9	-0.1	-0.4	-0.1	0.2
Pavlov. Cond. lever contacts	0.4	0.5	1.0	0.8	1.0	1.0	0.5	-0.1	-0.6	0.6
Pavlov. Cond. magazine entry number	0.3	0.4	0.7	-0.8	-0.6	-0.6	0.6	0.6	-0.8	0.2
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.0	-0.4	-1.0	-0.9	-1.0	-0.8	0.7	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	0.5	0.3	0.3	-0.4	-0.6	0.3	-0.1
Pavlov. Cond. response bias	0.1	0.1	0.3	0.6	0.5	0.5	-0.2	-0.2	0.1	0.1
Pavlov. Cond. lever latency	0.1	0.2	0.4	-0.5	-0.6	-0.5	-0.3	0.2	-0.1	-0.5
Pavlov. Cond. magazine entry latency	1.1	1.3	3.1	0.5	1.3	1.2	1.0	0.5	-1.1	1.8
Pavlov. Cond. change in total contacts	0.2	0.2	0.8	0.9	0.5	0.5	0.3	-0.6	0.0	0.1
Pavlov. Cond. index score	0.3	0.4	0.7	0.6	0.8	0.8	0.7	0.1	-0.2	0.8
Pavlov. Cond. latency score	0.2	0.3	0.5	0.4	0.7	0.6	0.6	0.1	-0.2	0.7
Pavlov. Cond. lever contacts	0.4	0.5	0.8	0.9	0.8	0.8	0.8	0.5	-0.2	0.6
Pavlov. Cond. magazine entry number	0.8	0.9	1.8	-0.8	-1.2	-1.1	-0.8	-0.3	0.6	-1.3
Pavlov. Cond. intertrial magazine entries	2.1	2.8	4.5	-2.1	-2.0	-2.0	-1.3	-1.5	1.1	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	0.6	0.8	0.7	0.8	0.1	-0.4	0.9
Pavlov. Cond. response bias	1.3	1.8	2.5	1.1	1.5	1.5	1.6	0.9	-1.1	1.6
Time in closed arm before self-admin	1.1	1.3	3.0	0.4	-0.4	-0.4	-1.7	-1.0	1.7	-1.3
Time in closed arm after self-admin	0.3	0.3	0.7	0.8	0.8	0.6	0.2	-0.1	0.5	0.3
Time in open arm before self-admin	0.2	0.3	1.0	-1.0	-0.5	-0.7	0.3	0.2	-0.1	-0.2
Time in open arm after self-admin	0.4	0.5	0.9	0.6	0.6	0.8	0.6	0.7	-1.0	0.5
Bone: periosteal estimation	0.1	0.3	0.6	0.8	0.6	0.6	0.5	0.4	-0.2	0.5
Bone: periosteal perimeter	0.1	0.1	0.4	0.4	0.1	-0.0	-0.3	0.1	0.6	-0.1
Bone: post-yield work	0.9	1.2	2.5	0.8	1.2	1.2	0.9	0.6	-1.2	1.6
Progressive ratio test 1 active lever presses	0.8	0.8	1.2	-0.7	-0.8	-1.1	-0.8	-0.8	1.0	-1.1
Progressive ratio test 1 breakpoint	0.7	0.8	1.3	-0.6	-0.8	-1.1	-0.7	-0.6	1.0	-1.1
Progressive ratio test 1 inactive lever presses	0.7	0.8	1.8	1.0	1.3	1.0	0.8	0.5	-0.4	0.8
Progressive ratio test 2 active lever presses	0.1	0.1	0.3	0.1	0.0	-0.1	-0.4	-0.6	0.1	-0.1
Progressive ratio test 2 breakpoint	0.2	0.2	0.7	-0.3	-0.3	-0.5	-0.5	-0.8	0.2	-0.2
Progressive ratio test 2 inactive lever presses	0.5	0.6	1.4	0.8	1.2	0.9	0.6	0.2	-0.3	0.8
Incentive Sensitization - Responses	0.5	0.5	1.4	0.5	0.5	0.7	0.5	0.2	-1.2	1.0
Incentive Sensitization - Breakpoint	0.6	0.6	1.6	0.3	0.5	0.7	0.6	0.2	-1.2	1.1
Sum of active levers in priming session hrs 5-6	0.9	0.9	3.0	0.0	-0.5	-0.7	-0.8	0.4	1.2	-1.7
Progressive ratio	2.8	3.2	4.7	-1.5	-2.0	-1.9	-2.2	-1.5	1.5	-1.8
Food seeking constrained by brief footshock	0.2	0.3	0.5	-0.6	-0.4	-0.6	-0.7	-0.4	0.7	-0.4
Seeking ratio, punishment vs. effort	1.2	1.4	2.1	1.0	1.4	1.2	1.5	1.3	-0.8	1.1
Retroperitoneal fat weight	0.1	0.4	1.3	0.0	0.4	0.3	0.8	-0.2	-1.1	0.6
Reaction time number correct	0.4	0.6	1.5	-1.2	-1.1	-0.9	0.1	-0.8	-0.2	-0.3
Reaction time mean minus median	0.3	0.4	1.2	1.1	0.6	0.6	0.0	1.0	0.0	-0.2
Reaction time mean minus median AUC	0.2	0.3	1.0	1.0	0.6	0.6	-0.1	0.5	0.0	-0.0
Reaction time num false alarms	0.7	0.9	2.3	-1.5	-1.1	-1.2	-0.8	-0.8	0.4	-0.2
Reaction time num false alarms AUC	0.7	1.0	3.0	-1.7	-1.3	-1.3	-0.5	-0.4	-0.0	-0.2
Reaction time trials correct on left	0.4	0.6	1.5	-1.2	-1.1	-0.9	0.1	-0.8	-0.2	-0.3
Reaction time trials on left	0.4	0.6	1.4	-1.2	-1.0	-0.9	0.1	-0.8	-0.2	-0.3
Reaction time mean	0.6	0.8	2.8	1.7	0.9	0.9	-0.8	0.4	0.7	-0.2
Reaction time mean AUC	0.5	0.7	2.1	1.5	0.7	0.6	-1.0	0.1	0.8	-0.4
Median of all reaction times	0.6	0.8	2.5	1.6	0.8	0.8	-1.1	0.0	0.9	-0.3
Reaction time omissions	0.5	0.6	1.4	1.2	0.8	0.8	0.4	1.1	-0.5	0.0
Reaction time false alarm rate	0.2	0.2	0.7	-0.8	-0.5	-0.6	-0.4	0.1	-0.0	0.1
Reaction time premature initiation rate	0.1	0.1	0.3	0.2	0.6	0.4	0.2	-0.3	0.3	0.4
Reaction time premature initiations	0.1	0.1	0.5	-0.4	-0.0	-0.0	0.2	-0.7	0.2	0.2
Std. dev. reaction times	0.5	0.7	2.0	1.4	0.9	0.9	0.2	1.2	-0.2	0.1
Reaction time trials completed	0.4	0.6	1.4	-1.2	-1.0	-0.9	0.1	-0.8	-0.2	-0.3
Reaction time trials AUC	0.4	0.5	1.3	-1.1	-1.0	-0.9	0.1	-0.7	-0.2	-0.3
Run reversals in cocaine runway, females	0.3	0.3	0.9	-0.9	-0.4	-0.3	-0.4	-0.3	0.1	0.7
Run reversals in cocaine runway, males	0.5	0.5	1.8	-0.5	-0.0	-0.5	-0.7	-0.6	1.3	-0.4
Latency to leave start box in cocaine runway	0.4	0.4	1.1	-1.0	-0.0	-0.0	0.4	-0.4	-0.7	1.1
Latency to leave start box in cocaine runway, F	1.3	1.4	3.2	-0.1	0.9	0.9	1.4	0.9	-1.4	1.8
Latency to leave start box in cocaine runway, M	2.0	1.9	3.4	-1.8	-1.5	-1.6	-1.1	-1.8	0.7	-0.7
Std. dev. time between licks in bursts	0.5	0.6	1.1	-1.0	-1.1	-0.9	0.5	0.8	-0.4	-0.7
Total sessions with >9 infusions	1.3	1.4	2.2	-1.1	-1.3	-1.5	-0.6	-1.4	1.0	-1.2
Short access day 1 total inactive lever presses	0.9	1.0	2.4	0.1	1.0	0.7	1.6	0.9	-0.9	1.1
Short access day 10 total inactive lever presses	1.0	1.1	2.5	0.8	1.6	1.4	0.3	0.4	-0.3	1.5
Short access day 1 total infusions	0.1	0.1	0.3	-0.6	-0.1	-0.4	0.5	-0.3	0.3	-0.3
Short access day 10 total infusions	4.6	5.1	10.4	-0.3	-1.4	-1.8	-2.5	-2.5	3.2	-2.7
Short access total infusions	1.3	1.5	2.7	-0.4	-0.9	-1.2	-1.0	-1.5	1.6	-1.5
Short access day 1 locomotion	0.3	0.3	0.6	-0.7	-0.7	-0.7	0.0	-0.4	0.5	-0.6
Short access day 10 total locomotion	0.1	0.1	0.2	0.4	0.4	0.2	0.2	-0.0	0.2	-0.3
Short access total locomotion	0.1	0.1	0.2	-0.3	-0.4	-0.4	0.1	-0.4	0.1	-0.2
One hour access (0.3 mA shock)	2.4	2.8	5.8	0.9	-0.5	-0.7	-2.3	-1.3	2.4	-2.4
Compulsive drug intake	0.1	0.1	0.4	0.2	-0.1	0.1	-0.0	0.6	-0.2	-0.0
One hour access (shock baseline)	1.9	2.2	4.8	0.7	-0.3	-0.6	-2.0	-1.4	2.2	-1.8
Social response proportion	0.1	0.2	0.4	0.2	0.4	0.2	-0.5	0.1	0.6	-0.4
Social responses	0.4	0.6	1.4	1.2	0.8	0.6	-0.7	0.5	0.6	-0.5
Social time	1.9	2.5	8.0	2.8	2.2	2.0	0.0	0.1	0.5	0.8
Soleus weight	0.5	1.4	3.5	-1.9	-1.1	-1.0	1.2	0.9	-1.5	-0.0
Bone: stiffness	0.6	1.0	2.1	0.2	0.9	0.9	1.0	0.4	-1.5	1.4
Tibialis anterior weight	1.0	3.5	12.3	-3.5	-2.4	-2.3	0.5	-0.1	-0.9	-0.3
Time to tail flick, vehicle, before self-admin	0.0	0.1	0.1	0.4	-0.0	0.1	-0.3	0.2	-0.2	-0.1
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.7	0.1	-0.2	-0.1	-0.8	-0.8	0.5	-0.4
Time to tail flick, test, before self-admin	2.3	2.2	4.1	-2.0	-1.9	-1.8	-1.1	-1.1	1.0	-0.9
Time to tail flick, test, after self-admin	1.0	1.0	1.9	-1.4	-1.3	-1.1	-0.7	-0.8	0.4	-0.8
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	-0.2	-0.2	-0.2	-0.1	-0.5	0.1	-0.1
Delta time to tail flick, test, before/after SA	0.2	0.2	0.6	0.8	0.5	0.5	0.2	-0.0	-0.1	-0.3
Tibia length	0.7	1.9	2.5	1.6	1.4	1.5	1.1	1.2	-1.3	1.5
Ambulatory time before self-admin	0.2	0.2	0.6	0.0	0.3	0.5	0.5	0.8	-0.6	0.1
Ambulatory time after self-admin	2.3	2.5	4.5	0.6	1.7	1.5	2.1	1.7	-1.6	1.6
Bone: tissue strength	0.1	0.1	0.3	-0.2	-0.2	-0.2	-0.1	-0.6	-0.2	0.1
Total heroin consumption	1.0	1.1	2.9	0.7	-0.1	-0.4	-1.5	-0.3	1.7	-1.5
Bone: trabecular number	2.6	4.1	9.0	3.0	2.6	2.6	1.2	0.9	-0.7	1.8
Bone: trabecular spacing	1.0	1.3	4.0	-2.0	-1.2	-1.2	-0.6	-1.1	0.0	-0.6
Bone: trabecular thickness	1.9	2.3	7.7	2.8	1.9	1.9	0.4	0.5	0.0	0.6
Bone: trabecular tissue density	0.3	0.5	1.2	-0.0	0.5	0.5	0.5	0.7	-0.9	1.1
Water consumed over 24 hours	0.6	0.7	2.6	-0.4	-0.3	-0.4	-0.9	-1.6	0.9	-0.4
Number of responses in last shaping day	0.3	0.3	0.8	0.9	0.7	0.6	0.1	0.4	-0.0	0.3