LOC102546698

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg gene expression LOC102546698 0.19 0.11 7.8e-04 0.15 0.12 0.13 0.13 8.8e-05 3.3e-04 2.9e-04 2.0e-04
2 RMTg mRNA stability LOC102546698 0.24 0.11 3.6e-05 0.1 0.07 0.03 0.08 1.4e-03 7.3e-03 6.7e-02 4.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density1.32.23.3-1.8-1.1
Area under the delay curve0.00.10.1-0.3-0.1
BMI with tail0.10.20.5-0.1-0.7
BMI without tail1.93.94.6-2.1-1.8
Body weight2.49.810.4-3.2-3.1
Weight adjusted by age0.30.40.60.80.4
Bone surface5.39.313.0-3.6-2.3
Bone volume4.37.39.3-3.1-2.3
Breakpoint value in progressive ratio session0.70.80.9-0.8-1.0
Number of licking bursts0.10.10.20.40.1
Context. condit. distance diff. score0.20.20.40.60.1
Locomotion velocity, session 11.51.62.8-1.7-0.6
Locomotion distance, session 10.60.81.5-1.20.2
Locomotion velocity, session 20.30.30.5-0.7-0.4
Locomotion distance, session 20.10.20.3-0.50.3
Locomotion velocity, session 30.30.30.50.50.7
Locomotion distance, session 30.10.10.1-0.20.3
Stereotopy head waving bouts, day 30.20.20.30.20.6
Stereotopy head waving duration, day 30.10.20.20.40.4
Locomotion velocity, session 70.30.40.60.30.8
Locomotion distance, session 70.00.10.1-0.10.3
Stereotopy head waving bouts, day 70.50.60.70.60.8
Stereotopy head waving duration, day 72.22.73.11.81.5
Locomotion velocity, session 80.30.40.7-0.3-0.8
Locomotion distance, session 80.00.00.00.2-0.2
Degree of sensitization distance0.20.20.2-0.4-0.5
Degree of sensitization stereotypy1.41.51.51.21.2
Conditioned locomotion0.50.60.9-0.6-0.9
Cocaine response after cond. corrected0.60.61.30.21.1
Cocaine response after cond. not corrected1.01.22.20.31.5
Cocaine response before conditioning0.10.10.20.40.3
Saline control response1.62.03.4-0.8-1.9
Bone: connectivity density2.03.14.6-2.2-1.2
Bone: cortical apparent density2.83.74.31.82.1
Bone: cortical area1.82.73.5-1.9-1.4
Bone: cortical porosity6.87.49.5-3.1-2.3
Bone: cortical porosity4.04.46.0-2.4-1.7
Bone: cortical thickness2.44.05.71.52.4
Bone: cortical thickness3.13.64.61.62.1
Bone: cortical tissue density2.73.64.11.82.0
Condit. Reinf. active minus inactive responses2.73.13.2-1.7-1.8
Condit. Reinf. active-inactive response ratio0.90.91.3-0.7-1.2
Condit. Reinf. active responses3.74.65.0-2.1-2.2
Condit. Reinf. inactive responses1.82.12.9-1.7-1.2
Incentive salience index mean2.83.44.0-2.0-1.7
Condit. Reinf. lever presses0.50.60.8-0.9-0.6
Condit. Reinf. active minus inactive responses6.07.48.6-2.9-2.5
Condit. Reinf. active-inactive response ratio3.23.34.0-2.0-1.6
Condit. Reinf. active responses7.19.89.8-3.1-3.1
Condit. Reinf. inactive responses2.43.03.9-1.5-2.0
Condit. Reinf. lever presses2.23.03.3-1.8-1.7
Condit. Reinf. lever reinforcers received6.18.58.8-3.0-2.9
Conditioned reinforcement - actives1.01.01.3-1.1-0.9
Conditioned reinforcement - inactives1.21.41.4-1.2-1.2
Conditioned locomotion3.44.14.2-2.0-2.0
Patch foraging indifference point 0 sec4.47.07.3-2.6-2.7
Patch foraging indifference point AUC1.61.92.8-1.0-1.7
Delay disc. indifference point, 0s delay0.40.50.60.70.6
Delay disc. indifference point, 16s delay0.20.20.4-0.6-0.3
Delay disc. indifference point, 2s delay0.40.50.7-0.8-0.5
Delay disc. indifference point, 24s delay1.91.92.1-1.5-1.3
Delay disc. indifference point, 4s delay0.60.60.80.70.9
Delay disc. indifference point, 8s delay0.10.10.10.10.3
Indifference point function ln k0.30.40.70.20.8
Indifference point function log k0.30.40.70.20.8
Patch foraging total patch changes 0 sec4.77.77.8-2.8-2.7
Patch foraging total patch changes 12 sec5.57.19.4-2.2-3.1
Patch foraging total patch changes 18 sec3.03.94.8-1.7-2.2
Patch foraging total patch changes 24 sec4.85.95.9-2.4-2.4
Patch foraging total patch changes 6 sec2.73.94.5-1.9-2.1
Patch foraging time to switch 0 sec0.30.50.50.70.6
Patch foraging water rate 0 sec1.82.93.9-2.0-1.4
Patch foraging water rate 12 sec1.11.72.41.01.5
Patch foraging water rate 18 sec0.20.30.7-0.10.8
Patch foraging water rate 24 sec0.20.30.50.00.7
Patch foraging water rate 6 sec0.10.20.3-0.30.5
Seeking ratio, delayed vs. immediate footshock0.10.10.1-0.3-0.3
Distance traveled before self-admin0.50.50.70.50.8
Distance traveled after self-admin0.20.20.20.50.3
Extensor digitorum longus weight0.93.66.32.51.0
Bone: elastic displacement1.51.62.80.71.7
Bone: elastic work0.50.71.3-1.10.2
Bone: endosteal estimation14.230.933.0-5.7-5.4
Bone: endosteal perimeter15.632.433.0-5.6-5.7
Epididymis fat weight1.22.93.4-1.8-1.6
Delta time in closed arm before/after self-admin0.00.00.0-0.00.2
Delta time in open arm before/after self-admin0.30.20.50.70.2
Diff in mean of infusions in LGA sessions0.70.81.11.00.8
Delay discount exponential model param0.20.20.30.50.3
Extinction: sum of active levers before priming0.50.50.9-0.4-0.9
Active lever presses in extinction session 62.62.52.7-1.6-1.6
Bone: final force1.01.62.9-1.7-0.5
Bone: final moment1.21.93.5-1.9-0.6
Food consumed during 24 hour testing period3.33.94.5-1.8-2.1
Glucose1.32.02.31.51.3
Heart weight0.10.10.1-0.10.4
Delay discount hyperbolic model param0.10.10.20.40.3
Intermittent access intake day 1-15 change0.10.10.1-0.0-0.4
Intermittent access intake escalation0.00.00.00.1-0.0
Intermittent access intake escalation 20.30.30.4-0.4-0.6
Intermitt. access day 1 inactive lever presses5.25.56.3-2.5-2.2
Intermitt. access day 15 inactive lever presses2.62.83.6-1.9-1.4
Intermitt. access escalation Index5.04.45.02.22.0
Intermittent access day 1 total infusions1.01.21.6-1.3-0.9
Intermittent access day 15 total infusions0.60.60.7-0.9-0.7
Intermittent access terminal intake (last 3 days)2.52.73.0-1.7-1.6
Intermittent access total infusions3.33.64.2-2.1-1.7
Intermittent access day 1 locomotion4.95.26.3-2.5-2.0
Intermittent access day 15 total locomotion6.06.46.8-2.6-2.5
Intermittent access total locomotion9.711.112.4-3.5-3.1
Intermittent access standard deviation1.71.81.8-1.4-1.3
Left kidney weight0.51.42.40.61.6
Right kidney weight0.20.71.4-0.11.2
Cocaine induced anxiety0.20.30.5-0.10.7
Post-drug Anxiety0.30.30.7-0.00.8
Baseline Anxiety0.60.60.70.70.9
Tail length2.88.410.5-3.2-2.5
Length with tail2.38.410.5-3.2-2.5
Length without tail0.20.50.6-0.8-0.7
Times rat made contact with spout1.11.31.8-1.3-0.9
Lifetime Intake3.74.24.9-2.2-1.9
Liver weight, left0.61.01.4-0.8-1.2
Liver weight, right0.20.40.60.40.7
Locomotor activity0.20.40.6-0.8-0.3
Locomotor testing distance1.32.23.0-1.7-1.2
Locomotor testing rearing0.81.21.4-1.2-1.0
Locomotion in novel chamber0.10.10.1-0.10.3
Locomotion in novel chamber post-restriction1.82.22.4-1.5-1.4
Fecal boli incidents, locomotor time 10.00.00.0-0.1-0.1
Change in fecal boli incidents, locomotor task0.00.00.00.10.1
Time >=10cm from walls, locomotor time 13.23.33.61.91.7
Bouts of movement, locomotor time 10.20.30.30.50.5
Total resting periods, locomotor time 10.30.30.40.50.6
Rest time, locomotor task time 10.20.20.4-0.00.6
Distance moved, locomotor task time 10.50.50.7-0.6-0.8
Vertical activity count, locomotor time 10.20.20.3-0.5-0.3
Time >=10cm from walls, locomotor time 20.30.30.50.40.7
Bouts of movement, locomotor time 20.40.40.80.90.2
Total resting periods, locomotor time 20.70.81.31.10.5
Rest time, locomotor task time 23.54.04.02.02.0
Distance moved, locomotor task time 20.40.50.6-0.8-0.6
Vertical activity count, locomotor time 23.43.74.7-2.2-1.7
Light reinforcement 10.30.60.6-0.7-0.8
Light reinforcement 20.81.11.4-1.2-0.9
Bone: marrow area13.829.932.2-5.7-5.2
Bone: maximum diameter4.58.39.1-3.0-2.7
Bone: maximum force2.13.65.6-2.4-1.3
Bone: maximum moment2.34.06.3-2.5-1.3
Mean time between licks in bursts0.20.20.4-0.6-0.3
Mean num. licks in bursts0.81.01.4-1.2-0.7
Cd content in liver3.03.34.02.01.6
Co content in liver0.70.91.61.20.4
Cu content in liver0.20.20.4-0.3-0.6
Fe content in liver0.10.10.20.50.1
K content in liver0.40.40.8-0.1-0.9
Mg content in liver0.40.40.50.7-0.5
Mn content in liver0.00.00.00.00.1
Na content in liver0.50.61.00.3-1.0
Rb content in liver3.74.65.52.41.9
Se content in liver1.51.93.01.70.9
Sr content in liver0.50.40.8-0.9-0.2
Zn content in liver0.00.00.0-0.20.0
Bone: minimum diameter13.725.626.3-5.1-5.0
Time in familiar zone, hab. session 10.60.61.0-0.4-1.0
Time in novel zone, hab. session 11.11.11.40.91.2
Total zone transitions, hab. session 10.30.51.0-1.0-0.1
Total locomotion distance, hab. session 11.62.24.3-2.1-0.4
Locomotion velocity, hab. session 12.02.95.4-2.3-0.6
Time in familiar zone, hab. session 21.31.31.9-0.9-1.4
Time in novel zone, hab. session 21.31.32.20.71.5
Total zone transitions, hab. session 20.00.00.0-0.2-0.2
Total locomotion distance, hab. session 20.81.01.6-1.3-0.6
Locomotion velocity, hab. session 20.81.01.7-1.3-0.6
Novel to familiar place preference ratio0.30.30.3-0.5-0.6
Novelty place preference0.10.10.2-0.3-0.4
Time in novel zone, NPP test0.00.00.1-0.2-0.2
Total zone transitions, NPP test0.10.20.4-0.60.1
Total locomotion distance, NPP test1.01.42.7-1.7-0.4
Locomotion velocity, NPP test0.81.22.1-1.5-0.5
Intraocular pressure1.11.52.2-1.5-0.9
Delta distance traveled before/after self-admin0.20.20.30.50.3
Delta ambulatory time before/after self-admin0.10.10.1-0.3-0.3
Parametrial fat weight1.22.34.0-2.0-0.8
Pavlov. Cond. lever latency2.22.84.02.01.3
Pavlov. Cond. magazine entry latency3.64.74.9-2.2-2.1
Pavlov. Cond. change in total contacts3.33.53.5-1.9-1.9
Pavlov. Cond. index score3.44.34.5-2.1-2.0
Pavlov. Cond. latency score2.73.53.6-1.9-1.8
Pavlov. Cond. lever contacts1.92.32.8-1.7-1.3
Pavlov. Cond. magazine entry number2.83.53.71.81.9
Pavlov. Cond. intertrial magazine entries1.31.62.0-1.0-1.4
Pavlov. Cond. lever-magazine prob. diff.3.13.94.2-2.0-1.9
Pavlov. Cond. response bias3.94.75.8-2.4-1.9
Pavlov. Cond. lever latency0.30.40.50.50.7
Pavlov. Cond. magazine entry latency2.93.33.41.81.8
Pavlov. Cond. change in total contacts0.30.40.8-0.3-0.9
Pavlov. Cond. index score0.00.00.00.10.1
Pavlov. Cond. latency score0.10.10.10.20.4
Pavlov. Cond. lever contacts0.30.50.5-0.6-0.7
Pavlov. Cond. magazine entry number3.54.35.0-1.9-2.2
Pavlov. Cond. intertrial magazine entries15.720.421.1-4.4-4.6
Pavlov. Cond. lever-magazine prob. diff.0.10.10.10.30.3
Pavlov. Cond. response bias0.00.00.0-0.1-0.1
Time in closed arm before self-admin1.01.11.50.81.2
Time in closed arm after self-admin1.21.31.61.01.3
Time in open arm before self-admin0.70.80.80.80.9
Time in open arm after self-admin0.10.10.3-0.1-0.5
Bone: periosteal estimation10.020.723.6-4.9-4.2
Bone: periosteal perimeter5.08.39.4-3.1-2.7
Bone: post-yield work1.82.52.8-1.7-1.5
Progressive ratio test 1 active lever presses5.35.66.4-2.5-2.2
Progressive ratio test 1 breakpoint6.87.27.6-2.8-2.6
Progressive ratio test 1 inactive lever presses5.35.86.2-2.5-2.3
Progressive ratio test 2 active lever presses5.96.37.0-2.6-2.4
Progressive ratio test 2 breakpoint6.87.68.9-3.0-2.5
Progressive ratio test 2 inactive lever presses5.56.47.3-2.7-2.3
Incentive Sensitization - Responses3.23.33.6-1.9-1.7
Incentive Sensitization - Breakpoint2.93.03.4-1.8-1.6
Sum of active levers in priming session hrs 5-60.20.20.30.60.2
Progressive ratio0.20.20.30.40.6
Food seeking constrained by brief footshock3.03.74.0-1.9-2.0
Seeking ratio, punishment vs. effort1.92.32.8-1.4-1.7
Retroperitoneal fat weight1.75.57.5-2.7-1.9
Reaction time number correct0.81.11.90.61.4
Reaction time mean minus median0.20.30.30.60.5
Reaction time mean minus median AUC0.91.21.31.11.1
Reaction time num false alarms3.34.44.6-2.1-2.1
Reaction time num false alarms AUC3.65.05.4-2.3-2.1
Reaction time trials correct on left0.81.11.90.61.4
Reaction time trials on left0.81.11.90.51.4
Reaction time mean1.01.41.71.31.1
Reaction time mean AUC1.41.82.31.51.2
Median of all reaction times1.01.41.71.31.1
Reaction time omissions0.00.00.0-0.20.2
Reaction time false alarm rate3.75.25.8-2.1-2.4
Reaction time premature initiation rate1.41.92.9-1.7-1.0
Reaction time premature initiations0.70.91.8-1.3-0.3
Std. dev. reaction times0.40.50.70.80.6
Reaction time trials completed0.81.11.90.51.4
Reaction time trials AUC0.81.11.90.61.4
Run reversals in cocaine runway, females0.40.40.80.00.9
Run reversals in cocaine runway, males0.00.00.00.20.1
Latency to leave start box in cocaine runway0.30.30.30.50.6
Latency to leave start box in cocaine runway, F0.50.60.60.70.8
Latency to leave start box in cocaine runway, M0.00.00.00.10.1
Std. dev. time between licks in bursts0.00.00.10.0-0.3
Total sessions with >9 infusions0.30.30.4-0.6-0.4
Short access day 1 total inactive lever presses1.01.11.7-1.3-0.7
Short access day 10 total inactive lever presses0.70.70.8-0.8-0.9
Short access day 1 total infusions1.21.21.4-1.2-1.0
Short access day 10 total infusions6.97.68.4-2.9-2.6
Short access total infusions3.53.94.5-2.1-1.8
Short access day 1 locomotion4.95.25.2-2.3-2.3
Short access day 10 total locomotion13.114.715.2-3.9-3.8
Short access total locomotion7.17.37.3-2.7-2.7
One hour access (0.3 mA shock)0.91.11.1-1.1-1.0
Compulsive drug intake1.91.92.91.01.7
One hour access (shock baseline)2.12.43.1-1.3-1.8
Social response proportion0.30.30.50.40.7
Social responses0.00.00.1-0.3-0.0
Social time0.10.20.2-0.30.5
Soleus weight0.20.50.6-0.7-0.6
Bone: stiffness0.60.91.0-1.0-0.9
Tibialis anterior weight0.31.12.2-0.1-1.5
Time to tail flick, vehicle, before self-admin0.20.20.40.20.7
Time to tail flick, vehicle, after self-admin1.11.21.5-1.2-1.0
Time to tail flick, test, before self-admin0.60.50.60.70.7
Time to tail flick, test, after self-admin0.00.00.10.30.1
Delta time to tail flick, vehicle, before/after SA3.13.13.6-1.9-1.6
Delta time to tail flick, test, before/after SA0.00.00.10.2-0.1
Tibia length0.20.60.8-0.90.5
Ambulatory time before self-admin0.30.30.40.40.6
Ambulatory time after self-admin0.10.10.1-0.4-0.1
Bone: tissue strength1.21.22.00.61.4
Total heroin consumption0.40.50.6-0.8-0.6
Bone: trabecular number2.13.34.8-2.2-1.3
Bone: trabecular spacing0.70.91.61.30.5
Bone: trabecular thickness3.34.05.6-2.4-1.5
Bone: trabecular tissue density0.60.81.50.31.2
Water consumed over 24 hours0.20.20.4-0.6-0.2
Number of responses in last shaping day1.11.21.6-1.3-0.9