LOC102546541

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	LOC102546541	0.7	0.09	0.0e+00	0.35	0.4	0.4	0.41	1.5e-40	7.3e-48	4.7e-48	1.2e-48
2	Liver	intron excision ratio	chr1_155701366_155703063	0.28	0.14	5.7e-15	0.07	0.1	0.09	0.1	1.7e-08	1.1e-11	1.5e-10	1.4e-11
3	Liver	intron excision ratio	chr1_155708732_155710770	0.41	0.16	0.0e+00	0.12	0.15	0.14	0.15	2.9e-13	6.0e-16	6.2e-15	6.1e-16
4	Liver	isoform ratio	XR_005494610.1	0.23	0.13	5.6e-13	0.09	0.08	0.1	0.09	2.1e-10	3.3e-09	6.0e-11	4.8e-10
5	Liver	alternative TSS	XR_005494610.1	0.24	0.17	5.1e-13	0.09	0.08	0.11	0.09	1.8e-10	2.4e-09	3.2e-12	3.9e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.8	1.4	2.2	1.0	-1.0	0.9	-1.5	-1.4
Area under the delay curve	0.3	0.3	0.5	0.4	-0.6	0.5	0.5	0.7
BMI with tail	0.2	0.5	1.2	0.8	-0.3	1.1	0.6	0.5
BMI without tail	0.8	1.7	3.5	-1.5	1.9	-1.3	1.0	0.3
Body weight	1.1	4.7	5.8	-2.4	2.3	-2.0	2.3	1.8
Weight adjusted by age	1.3	1.5	2.0	-1.3	1.4	-1.3	1.1	0.9
Bone surface	0.4	0.7	1.4	-0.7	0.6	-0.7	-0.9	-1.2
Bone volume	0.2	0.4	0.5	-0.7	0.5	-0.7	-0.5	-0.7
Breakpoint value in progressive ratio session	0.1	0.1	0.3	0.3	-0.4	0.5	-0.2	-0.1
Number of licking bursts	1.4	1.6	2.5	1.6	-1.5	1.5	0.6	0.9
Context. condit. distance diff. score	1.7	2.1	2.6	-1.5	1.5	-1.5	-1.1	-1.6
Locomotion velocity, session 1	1.7	1.8	2.2	1.5	-1.2	1.4	-1.4	-1.2
Locomotion distance, session 1	0.4	0.5	1.3	0.1	0.1	0.2	-1.1	-1.1
Locomotion velocity, session 2	0.0	0.0	0.1	0.1	0.1	0.2	-0.1	-0.0
Locomotion distance, session 2	0.1	0.1	0.2	-0.2	0.4	-0.0	0.3	0.3
Locomotion velocity, session 3	0.5	0.6	1.3	-0.4	0.3	-0.5	-1.0	-1.2
Locomotion distance, session 3	1.0	1.1	3.0	-0.0	0.1	-0.2	-1.6	-1.7
Stereotopy head waving bouts, day 3	0.7	0.8	1.6	-0.6	0.4	-0.5	1.3	1.3
Stereotopy head waving duration, day 3	0.0	0.0	0.0	-0.1	0.2	-0.1	-0.2	-0.2
Locomotion velocity, session 7	0.5	0.5	1.0	0.6	-0.4	0.5	-0.9	-1.0
Locomotion distance, session 7	0.1	0.1	0.4	0.0	-0.1	0.0	0.6	0.6
Stereotopy head waving bouts, day 7	1.7	1.9	3.8	-0.9	1.0	-1.0	-1.7	-2.0
Stereotopy head waving duration, day 7	1.5	1.8	3.3	-0.9	1.1	-1.0	-1.6	-1.8
Locomotion velocity, session 8	0.9	1.1	1.5	-1.2	1.1	-1.2	-0.6	-0.9
Locomotion distance, session 8	1.1	1.6	2.8	-1.6	1.7	-1.4	-0.3	-0.7
Degree of sensitization distance	3.7	3.7	7.8	-1.3	1.0	-1.0	2.8	2.7
Degree of sensitization stereotypy	3.1	3.4	6.1	-1.5	1.5	-1.6	-2.0	-2.5
Conditioned locomotion	0.7	0.9	2.4	-0.4	-0.1	-0.3	1.3	1.5
Cocaine response after cond. corrected	0.3	0.3	0.6	0.7	-0.6	0.8	0.2	0.2
Cocaine response after cond. not corrected	0.6	0.7	1.1	1.0	-0.8	1.0	-0.6	-0.6
Cocaine response before conditioning	1.4	1.7	4.2	0.3	-0.0	0.2	-2.0	-2.0
Saline control response	2.4	3.1	6.0	-2.4	2.0	-2.3	0.6	0.3
Bone: connectivity density	2.1	3.3	5.2	1.7	-1.3	1.5	-2.3	-2.2
Bone: cortical apparent density	0.7	0.9	2.2	0.0	-0.2	0.2	1.4	1.5
Bone: cortical area	0.8	1.2	1.9	-1.4	1.1	-1.2	1.0	0.8
Bone: cortical porosity	0.1	0.2	0.4	0.1	-0.4	0.1	-0.7	-0.4
Bone: cortical porosity	0.1	0.1	0.3	0.1	-0.3	0.0	-0.6	-0.3
Bone: cortical thickness	0.1	0.1	0.2	0.3	-0.3	0.4	0.4	0.5
Bone: cortical thickness	0.1	0.2	0.3	-0.3	0.1	-0.2	0.5	0.6
Bone: cortical tissue density	0.6	0.8	2.0	0.1	-0.3	0.2	1.4	1.4
Condit. Reinf. active minus inactive responses	1.1	1.3	2.1	-1.4	1.1	-1.4	0.9	0.6
Condit. Reinf. active-inactive response ratio	1.3	1.4	2.6	-1.6	1.3	-1.6	0.7	0.4
Condit. Reinf. active responses	0.8	1.0	1.7	-0.9	0.5	-0.8	1.2	1.3
Condit. Reinf. inactive responses	0.6	0.7	1.9	0.3	-0.5	0.5	1.0	1.4
Incentive salience index mean	0.7	0.9	1.1	-1.1	0.7	-0.9	1.0	1.1
Condit. Reinf. lever presses	0.1	0.1	0.2	0.1	-0.3	0.3	0.1	0.4
Condit. Reinf. active minus inactive responses	5.6	6.9	12.5	-3.5	3.3	-3.3	0.5	-0.1
Condit. Reinf. active-inactive response ratio	0.9	0.9	1.3	-1.1	1.1	-1.0	-0.6	-0.9
Condit. Reinf. active responses	8.0	11.2	19.6	-4.4	4.1	-4.1	1.4	0.8
Condit. Reinf. inactive responses	6.0	7.4	11.4	-3.4	3.0	-3.1	2.0	1.7
Condit. Reinf. lever presses	8.6	11.7	21.0	-4.6	4.4	-4.2	0.5	-0.3
Condit. Reinf. lever reinforcers received	7.6	10.8	19.4	-4.4	4.0	-4.0	1.2	0.6
Conditioned reinforcement - actives	0.0	0.0	0.1	0.0	-0.1	0.1	-0.3	-0.2
Conditioned reinforcement - inactives	0.6	0.7	2.0	-0.0	-0.2	0.1	1.1	1.4
Conditioned locomotion	0.3	0.4	0.9	0.0	0.1	-0.0	-1.0	-0.9
Patch foraging indifference point 0 sec	0.8	1.3	2.1	-1.4	1.5	-1.4	-0.3	-0.7
Patch foraging indifference point AUC	0.7	0.8	1.2	-1.1	1.1	-1.1	0.7	0.4
Delay disc. indifference point, 0s delay	0.4	0.4	0.8	-0.9	0.8	-0.8	0.3	0.2
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	0.1	-0.6	0.1	-0.0	0.0
Delay disc. indifference point, 2s delay	0.6	0.7	1.1	-1.1	0.8	-0.8	0.6	0.7
Delay disc. indifference point, 24s delay	0.7	0.7	1.3	0.5	-0.9	0.6	0.9	1.1
Delay disc. indifference point, 4s delay	1.5	1.5	2.1	-1.5	1.3	-1.3	1.1	1.0
Delay disc. indifference point, 8s delay	0.3	0.3	0.7	0.4	-0.6	0.5	0.5	0.8
Indifference point function ln k	0.5	0.8	1.6	0.4	-0.6	0.4	-1.3	-1.2
Indifference point function log k	0.5	0.8	1.6	0.4	-0.6	0.4	-1.3	-1.2
Patch foraging total patch changes 0 sec	0.6	1.0	1.8	-1.2	1.3	-1.2	-0.1	-0.5
Patch foraging total patch changes 12 sec	1.8	2.4	3.5	-1.9	1.8	-1.7	1.2	0.8
Patch foraging total patch changes 18 sec	0.6	0.7	1.2	-1.1	1.1	-1.1	0.3	0.1
Patch foraging total patch changes 24 sec	1.5	1.8	2.9	-1.7	1.7	-1.7	0.8	0.3
Patch foraging total patch changes 6 sec	0.3	0.4	0.6	-0.6	0.8	-0.7	-0.3	-0.6
Patch foraging time to switch 0 sec	1.8	2.8	4.8	2.1	-2.2	2.0	0.3	1.0
Patch foraging water rate 0 sec	1.2	1.9	2.7	-1.5	1.6	-1.6	-0.6	-1.2
Patch foraging water rate 12 sec	0.4	0.7	1.3	-0.6	1.1	-0.7	-0.5	-1.0
Patch foraging water rate 18 sec	1.6	2.1	4.1	-1.7	2.0	-1.7	-0.1	-0.8
Patch foraging water rate 24 sec	0.2	0.3	0.6	0.2	-0.1	0.3	-0.7	-0.8
Patch foraging water rate 6 sec	0.3	0.4	1.0	-0.3	0.5	-0.2	-0.7	-1.0
Seeking ratio, delayed vs. immediate footshock	2.5	2.9	4.6	2.1	-1.9	2.0	-1.2	-1.0
Distance traveled before self-admin	0.4	0.4	0.6	0.7	-0.4	0.6	0.7	0.7
Distance traveled after self-admin	0.3	0.4	1.0	0.2	-0.1	0.0	-0.8	-1.0
Extensor digitorum longus weight	0.1	0.3	0.9	-0.1	0.2	0.1	0.9	0.8
Bone: elastic displacement	2.4	2.7	4.2	2.1	-1.8	1.9	-1.3	-0.9
Bone: elastic work	4.5	5.8	8.8	3.0	-2.4	2.7	-2.1	-1.7
Bone: endosteal estimation	1.2	2.5	4.6	-2.1	1.9	-2.1	0.6	0.0
Bone: endosteal perimeter	1.3	2.7	4.9	-2.2	2.0	-2.1	0.4	-0.0
Epididymis fat weight	0.3	0.7	1.9	-0.1	0.3	-0.0	1.4	1.2
Delta time in closed arm before/after self-admin	2.0	1.9	4.8	-0.3	0.5	-0.5	2.2	2.0
Delta time in open arm before/after self-admin	1.3	1.3	2.6	-1.6	1.1	-1.3	-0.6	-0.7
Diff in mean of infusions in LGA sessions	0.4	0.5	1.1	0.2	-0.8	0.5	0.5	1.0
Delay discount exponential model param	0.4	0.4	0.6	-0.5	0.7	-0.6	-0.5	-0.8
Extinction: sum of active levers before priming	0.1	0.1	0.1	0.3	-0.3	0.3	-0.0	0.2
Active lever presses in extinction session 6	1.0	1.0	2.6	0.1	-0.1	0.1	-1.6	-1.6
Bone: final force	0.5	0.8	1.6	-0.6	0.1	-0.6	1.2	1.3
Bone: final moment	0.5	0.8	1.4	-0.8	0.3	-0.7	1.1	1.2
Food consumed during 24 hour testing period	1.0	1.2	2.1	-0.8	0.8	-0.7	-1.4	-1.4
Glucose	0.5	0.7	1.4	0.7	-0.4	0.6	-1.1	-1.2
Heart weight	0.5	0.7	0.9	-0.8	0.7	-0.8	-0.8	-0.9
Delay discount hyperbolic model param	0.3	0.3	0.8	-0.2	0.4	-0.4	-0.6	-0.9
Intermittent access intake day 1-15 change	0.1	0.1	0.2	0.1	0.3	0.2	-0.4	-0.5
Intermittent access intake escalation	0.1	0.1	0.2	0.3	0.1	0.4	-0.5	-0.5
Intermittent access intake escalation 2	0.3	0.3	0.8	0.2	0.1	0.3	0.9	0.8
Intermitt. access day 1 inactive lever presses	1.3	1.3	3.5	0.4	-0.9	0.7	1.3	1.9
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.0	-0.0	0.1	-0.2	-0.2	0.0
Intermitt. access escalation Index	0.0	0.0	0.1	-0.3	0.1	-0.2	0.2	-0.0
Intermittent access day 1 total infusions	0.6	0.7	1.3	-1.1	0.9	-1.1	0.0	0.0
Intermittent access day 15 total infusions	0.2	0.2	0.4	-0.7	0.6	-0.6	0.1	0.3
Intermittent access terminal intake (last 3 days)	0.4	0.5	0.7	-0.9	0.7	-0.7	0.4	0.5
Intermittent access total infusions	0.3	0.3	0.6	-0.8	0.6	-0.7	0.2	0.3
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.2	-0.4	0.2	-0.3	0.1
Intermittent access day 15 total locomotion	0.2	0.2	0.7	0.2	-0.1	0.2	-0.8	-0.4
Intermittent access total locomotion	0.1	0.1	0.2	-0.4	0.4	-0.4	0.0	0.3
Intermittent access standard deviation	0.4	0.4	0.9	0.4	-0.1	0.5	0.8	0.9
Left kidney weight	1.2	3.4	5.4	-2.2	2.3	-1.9	1.5	0.9
Right kidney weight	0.9	2.6	3.3	-1.8	1.8	-1.6	1.7	1.2
Cocaine induced anxiety	2.1	2.4	3.9	1.4	-1.6	1.4	1.3	2.0
Post-drug Anxiety	0.6	0.6	1.7	-0.3	-0.0	-0.4	1.1	1.3
Baseline Anxiety	1.9	2.0	2.8	-1.7	1.5	-1.6	-0.7	-1.2
Tail length	5.8	17.5	29.3	-5.4	5.0	-5.2	2.3	1.1
Length with tail	4.0	14.7	22.5	-4.7	4.1	-4.4	3.1	2.4
Length without tail	0.1	0.3	0.8	-0.1	-0.2	0.0	0.7	0.9
Times rat made contact with spout	0.1	0.1	0.3	-0.1	-0.0	0.1	0.4	0.6
Lifetime Intake	0.4	0.5	0.9	-0.9	0.8	-0.9	0.1	0.1
Liver weight, left	1.5	2.4	5.9	-0.6	-0.0	-0.4	2.4	2.4
Liver weight, right	1.9	3.1	6.4	-1.6	0.8	-1.2	2.5	2.2
Locomotor activity	0.3	0.5	0.8	-0.9	0.9	-0.8	0.4	0.2
Locomotor testing distance	1.4	2.3	3.9	-1.9	2.0	-1.7	0.8	0.3
Locomotor testing rearing	1.7	2.7	4.2	-2.1	1.8	-1.8	1.3	0.9
Locomotion in novel chamber	0.9	1.1	2.3	1.3	-1.3	1.5	-0.0	0.2
Locomotion in novel chamber post-restriction	0.9	1.1	3.0	0.2	-0.1	0.3	-1.7	-1.6
Fecal boli incidents, locomotor time 1	1.5	1.7	3.3	1.4	-1.8	1.6	0.1	0.7
Change in fecal boli incidents, locomotor task	0.3	0.3	0.8	-0.2	0.6	-0.6	-0.3	-0.9
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.4	-0.6	0.4	-0.6	0.3	0.1
Bouts of movement, locomotor time 1	0.1	0.1	0.3	-0.2	-0.0	-0.3	0.3	0.6
Total resting periods, locomotor time 1	0.1	0.1	0.4	0.4	-0.6	0.4	-0.1	0.2
Rest time, locomotor task time 1	0.4	0.4	1.1	0.0	-0.2	-0.2	-0.9	-1.0
Distance moved, locomotor task time 1	0.6	0.6	1.3	-0.5	0.5	-0.2	1.1	1.1
Vertical activity count, locomotor time 1	1.1	1.2	3.1	-0.7	0.4	-0.3	1.4	1.8
Time >=10cm from walls, locomotor time 2	2.7	2.8	5.0	-2.1	1.9	-2.2	0.9	0.4
Bouts of movement, locomotor time 2	2.4	2.6	3.7	-1.6	1.1	-1.5	1.9	1.9
Total resting periods, locomotor time 2	1.7	1.8	3.3	-1.1	0.7	-1.0	1.7	1.8
Rest time, locomotor task time 2	1.2	1.4	2.8	1.7	-1.5	1.4	-0.4	-0.1
Distance moved, locomotor task time 2	2.1	2.4	4.2	-2.0	1.9	-1.8	0.8	0.5
Vertical activity count, locomotor time 2	2.3	2.5	3.9	-1.5	1.1	-1.3	1.8	2.0
Light reinforcement 1	1.2	2.1	4.4	2.1	-1.6	1.9	-0.2	-0.0
Light reinforcement 2	1.5	2.0	2.9	1.7	-0.9	1.5	-1.5	-1.3
Bone: marrow area	1.0	2.2	3.9	-2.0	1.7	-1.9	0.6	0.1
Bone: maximum diameter	1.7	3.1	5.6	-2.4	2.1	-2.2	0.5	0.0
Bone: maximum force	0.1	0.2	0.3	-0.6	0.2	-0.6	0.6	0.5
Bone: maximum moment	0.1	0.2	0.5	-0.7	0.4	-0.6	0.4	0.3
Mean time between licks in bursts	8.9	12.5	17.5	-4.2	3.8	-3.9	3.1	2.5
Mean num. licks in bursts	1.3	1.5	2.5	-1.6	1.4	-1.5	-0.6	-0.8
Cd content in liver	0.2	0.2	0.3	0.6	-0.5	0.6	0.1	0.3
Co content in liver	2.6	3.0	5.2	-2.3	1.8	-2.1	1.2	0.9
Cu content in liver	1.3	1.6	2.6	-1.6	1.3	-1.5	0.9	0.7
Fe content in liver	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.1	0.2
K content in liver	1.1	1.1	3.3	0.0	-0.2	0.4	1.4	1.8
Mg content in liver	0.1	0.1	0.4	-0.2	0.1	0.0	0.5	0.7
Mn content in liver	2.2	2.5	4.1	2.0	-1.9	1.9	-1.0	-0.6
Na content in liver	0.7	0.8	2.0	0.0	-0.0	0.0	-1.4	-1.4
Rb content in liver	0.2	0.2	0.5	-0.7	0.5	-0.6	-0.3	-0.2
Se content in liver	2.6	3.1	5.4	2.3	-2.3	2.2	-0.5	0.0
Sr content in liver	1.1	1.0	2.4	0.8	-0.2	0.6	-1.3	-1.5
Zn content in liver	0.7	0.8	1.8	-1.1	1.4	-1.0	-0.0	-0.2
Bone: minimum diameter	2.1	3.9	5.2	-2.3	1.9	-2.0	1.9	1.6
Time in familiar zone, hab. session 1	0.3	0.3	0.6	-0.7	0.7	-0.7	0.3	0.2
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.4	-0.4	0.3	-0.1	-0.2
Total zone transitions, hab. session 1	0.7	0.9	2.1	0.4	-0.3	0.3	-1.5	-1.5
Total locomotion distance, hab. session 1	1.4	2.0	4.0	-1.1	1.0	-1.0	2.0	1.7
Locomotion velocity, hab. session 1	1.4	2.0	4.0	-1.0	0.8	-0.8	2.0	1.9
Time in familiar zone, hab. session 2	2.3	2.4	4.2	-2.0	1.8	-2.1	0.7	0.1
Time in novel zone, hab. session 2	1.5	1.5	2.9	1.6	-1.3	1.7	-0.6	-0.2
Total zone transitions, hab. session 2	1.2	1.6	2.9	-1.0	1.1	-1.0	-1.4	-1.7
Total locomotion distance, hab. session 2	3.6	4.8	6.0	-2.3	2.1	-2.1	2.5	2.0
Locomotion velocity, hab. session 2	3.9	5.2	6.9	-2.4	2.1	-2.1	2.6	2.2
Novel to familiar place preference ratio	1.2	1.3	2.2	-1.0	0.5	-1.0	1.3	1.5
Novelty place preference	1.3	1.3	2.0	-1.1	0.6	-1.1	1.3	1.4
Time in novel zone, NPP test	1.5	1.6	2.1	-1.3	0.8	-1.3	1.4	1.4
Total zone transitions, NPP test	0.3	0.4	0.6	0.6	-0.4	0.7	-0.8	-0.6
Total locomotion distance, NPP test	1.4	2.0	4.7	-0.6	0.7	-0.3	2.2	2.0
Locomotion velocity, NPP test	1.1	1.6	4.0	-0.3	0.4	-0.0	2.0	1.9
Intraocular pressure	3.1	4.3	7.7	1.6	-1.3	1.4	-2.8	-2.8
Delta distance traveled before/after self-admin	1.5	1.6	2.8	-1.7	1.2	-1.6	-0.7	-0.9
Delta ambulatory time before/after self-admin	1.2	1.3	2.0	-1.1	0.8	-1.1	-1.2	-1.4
Parametrial fat weight	0.3	0.6	1.3	1.1	-0.6	1.1	0.1	0.1
Pavlov. Cond. lever latency	0.4	0.5	1.0	1.0	-0.7	0.8	-0.2	-0.3
Pavlov. Cond. magazine entry latency	1.9	2.4	4.3	-2.1	2.0	-1.9	0.3	0.0
Pavlov. Cond. change in total contacts	0.7	0.8	1.6	-1.3	1.0	-1.2	-0.1	-0.2
Pavlov. Cond. index score	1.2	1.5	2.8	-1.7	1.5	-1.5	0.2	0.1
Pavlov. Cond. latency score	1.1	1.4	2.7	-1.6	1.4	-1.4	0.4	0.3
Pavlov. Cond. lever contacts	0.4	0.4	0.9	-0.9	0.8	-0.8	0.2	0.3
Pavlov. Cond. magazine entry number	1.2	1.5	2.7	1.6	-1.5	1.5	0.2	0.3
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.9	0.8	-1.0	0.8	-0.4	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	2.0	-1.4	1.3	-1.3	-0.0	-0.1
Pavlov. Cond. response bias	0.6	0.7	1.3	-1.2	1.1	-1.0	0.2	0.2
Pavlov. Cond. lever latency	8.9	12.0	20.9	4.5	-4.6	4.2	-0.2	0.7
Pavlov. Cond. magazine entry latency	1.0	1.2	2.6	-1.2	1.6	-1.1	-0.5	-0.8
Pavlov. Cond. change in total contacts	7.0	9.7	16.7	-4.0	4.1	-3.8	-0.3	-1.1
Pavlov. Cond. index score	6.1	7.9	14.3	-3.7	3.8	-3.4	0.1	-0.6
Pavlov. Cond. latency score	5.1	6.4	11.8	-3.3	3.4	-3.0	-0.1	-0.8
Pavlov. Cond. lever contacts	8.9	12.1	21.2	-4.6	4.6	-4.3	0.2	-0.6
Pavlov. Cond. magazine entry number	2.4	2.9	5.1	2.0	-2.3	1.8	0.8	1.2
Pavlov. Cond. intertrial magazine entries	1.0	1.3	1.6	-1.2	0.9	-1.0	1.3	1.2
Pavlov. Cond. lever-magazine prob. diff.	6.2	7.9	14.2	-3.7	3.8	-3.4	0.2	-0.5
Pavlov. Cond. response bias	8.5	11.5	20.3	-4.4	4.5	-4.1	0.0	-0.8
Time in closed arm before self-admin	1.5	1.7	4.3	-0.5	0.5	-0.6	-1.8	-2.1
Time in closed arm after self-admin	0.3	0.3	0.7	0.9	-0.8	0.6	-0.1	0.1
Time in open arm before self-admin	3.1	3.4	5.5	2.3	-2.0	2.2	1.0	1.4
Time in open arm after self-admin	0.1	0.2	0.3	-0.4	0.3	-0.3	0.5	0.4
Bone: periosteal estimation	1.0	2.0	3.6	-1.9	1.7	-1.7	0.7	0.3
Bone: periosteal perimeter	1.1	1.9	3.3	-1.8	1.7	-1.7	0.6	0.2
Bone: post-yield work	0.2	0.3	0.4	-0.6	0.6	-0.7	0.1	-0.4
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	0.0	0.0	-0.1	-0.3	-0.2
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	-0.1	0.1	-0.2	-0.2	-0.1
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	-0.2	-0.0	-0.0	0.1	0.4
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	-0.7	0.4	-0.6	0.2	0.4
Progressive ratio test 2 breakpoint	0.3	0.4	0.7	-0.8	0.6	-0.7	0.3	0.5
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.2	-0.1	-0.1	-0.0	0.3
Incentive Sensitization - Responses	0.9	0.9	1.8	-1.4	1.0	-1.1	0.6	0.6
Incentive Sensitization - Breakpoint	0.6	0.6	1.3	-1.1	0.8	-0.9	0.4	0.5
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	-0.1	0.3	-0.2	0.0	0.0
Progressive ratio	0.7	0.8	1.3	0.7	-0.5	0.7	-1.1	-1.1
Food seeking constrained by brief footshock	1.7	2.1	3.5	-1.9	1.8	-1.8	0.7	0.3
Seeking ratio, punishment vs. effort	2.5	3.0	4.0	-2.0	1.8	-1.8	1.6	1.4
Retroperitoneal fat weight	2.0	6.7	16.1	-1.0	0.9	-0.5	4.0	3.9
Reaction time number correct	0.1	0.2	0.2	0.5	-0.5	0.4	-0.5	-0.3
Reaction time mean minus median	0.8	1.1	1.5	-1.1	0.9	-0.9	1.2	1.1
Reaction time mean minus median AUC	0.5	0.7	0.9	-0.9	0.7	-0.7	0.9	0.8
Reaction time num false alarms	1.3	1.8	4.0	0.7	-0.9	0.8	1.7	2.0
Reaction time num false alarms AUC	1.4	2.0	4.2	0.9	-1.1	1.0	1.6	2.1
Reaction time trials correct on left	0.1	0.2	0.2	0.5	-0.5	0.4	-0.5	-0.3
Reaction time trials on left	0.1	0.2	0.3	0.5	-0.5	0.5	-0.5	-0.2
Reaction time mean	1.4	1.9	5.3	-0.1	-0.4	0.2	2.0	2.3
Reaction time mean AUC	1.1	1.5	3.9	0.2	-0.7	0.5	1.6	2.0
Median of all reaction times	1.4	1.9	4.8	0.4	-0.9	0.7	1.8	2.2
Reaction time omissions	0.8	1.0	2.8	0.4	-0.5	0.7	1.2	1.7
Reaction time false alarm rate	1.3	1.9	4.3	0.7	-0.8	0.8	1.8	2.1
Reaction time premature initiation rate	2.5	3.3	4.9	-2.2	2.2	-2.0	1.4	0.8
Reaction time premature initiations	1.1	1.6	2.2	-1.5	1.5	-1.4	1.1	0.7
Std. dev. reaction times	1.6	2.3	4.3	-1.2	0.8	-0.9	2.1	2.1
Reaction time trials completed	0.1	0.2	0.3	0.5	-0.5	0.5	-0.5	-0.2
Reaction time trials AUC	0.0	0.1	0.1	0.3	-0.3	0.2	-0.2	-0.0
Run reversals in cocaine runway, females	3.1	3.0	4.3	-1.5	1.7	-1.3	2.1	1.9
Run reversals in cocaine runway, males	0.5	0.5	1.0	0.9	-1.0	0.9	-0.3	-0.0
Latency to leave start box in cocaine runway	0.3	0.3	0.8	0.9	-0.6	0.7	-0.2	0.0
Latency to leave start box in cocaine runway, F	0.2	0.2	0.5	0.3	-0.1	0.1	0.6	0.7
Latency to leave start box in cocaine runway, M	1.4	1.4	2.1	1.4	-1.2	1.2	-1.1	-0.8
Std. dev. time between licks in bursts	4.7	5.7	7.6	-2.4	2.1	-2.2	2.7	2.4
Total sessions with >9 infusions	1.2	1.3	2.3	-0.8	1.1	-0.9	-1.3	-1.5
Short access day 1 total inactive lever presses	0.5	0.5	1.5	0.4	-0.8	0.5	0.4	1.2
Short access day 10 total inactive lever presses	0.9	1.0	1.3	0.9	-1.0	1.0	0.7	1.2
Short access day 1 total infusions	1.1	1.2	2.1	-1.5	1.3	-1.4	0.4	0.4
Short access day 10 total infusions	0.7	0.8	1.6	-1.3	1.1	-1.1	0.1	-0.1
Short access total infusions	0.7	0.8	1.3	-1.1	1.1	-1.1	-0.0	-0.2
Short access day 1 locomotion	1.1	1.2	2.8	0.6	-0.5	0.6	-1.7	-1.5
Short access day 10 total locomotion	0.4	0.5	1.4	-0.1	0.2	0.1	0.9	1.2
Short access total locomotion	0.1	0.1	0.2	0.3	-0.2	0.3	-0.4	-0.2
One hour access (0.3 mA shock)	0.5	0.6	0.8	-0.8	0.9	-0.6	0.8	0.6
Compulsive drug intake	1.3	1.3	2.0	1.4	-1.3	1.3	-0.9	-0.8
One hour access (shock baseline)	1.4	1.6	2.4	-1.5	1.4	-1.3	1.1	0.9
Social response proportion	1.5	1.6	4.5	-0.1	0.1	0.1	1.9	2.1
Social responses	3.7	4.8	12.0	-0.9	0.8	-0.7	3.2	3.5
Social time	1.1	1.5	2.3	1.5	-1.4	1.4	0.4	1.0
Soleus weight	0.8	2.5	5.4	-0.9	0.9	-0.7	2.3	2.2
Bone: stiffness	1.2	1.8	3.7	-1.0	0.4	-0.9	1.9	1.9
Tibialis anterior weight	0.3	1.2	1.7	-1.3	1.1	-1.1	1.1	0.8
Time to tail flick, vehicle, before self-admin	0.5	0.5	1.2	-0.1	0.3	-0.4	-1.0	-1.1
Time to tail flick, vehicle, after self-admin	1.4	1.5	3.5	-0.4	0.4	-0.6	-1.8	-1.9
Time to tail flick, test, before self-admin	1.0	1.0	1.6	-1.1	1.2	-1.3	-0.2	-0.6
Time to tail flick, test, after self-admin	2.2	2.3	4.1	-2.0	1.8	-2.0	0.6	0.1
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.0	0.2	-0.3	0.2	-1.0	-0.9
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	0.0	-0.0	0.1	0.2	0.1
Tibia length	0.1	0.3	0.8	-0.9	0.3	-0.6	-0.4	-0.1
Ambulatory time before self-admin	0.6	0.6	1.6	1.2	-0.7	0.8	0.4	0.4
Ambulatory time after self-admin	0.6	0.7	1.7	0.1	0.0	-0.2	-1.2	-1.3
Bone: tissue strength	2.5	2.4	2.9	1.6	-1.3	1.5	-1.7	-1.5
Total heroin consumption	0.4	0.5	0.9	-0.9	0.9	-0.8	0.4	0.2
Bone: trabecular number	1.8	2.8	3.6	1.9	-1.7	1.7	-1.7	-1.3
Bone: trabecular spacing	0.1	0.1	0.2	-0.2	0.4	-0.1	-0.2	-0.2
Bone: trabecular thickness	0.6	0.7	1.1	-0.9	0.4	-0.9	1.0	1.0
Bone: trabecular tissue density	3.2	4.5	9.9	-1.4	0.7	-1.1	3.0	3.1
Water consumed over 24 hours	0.6	0.8	1.1	1.0	-1.1	1.0	-0.7	-0.4
Number of responses in last shaping day	0.4	0.4	0.7	-0.6	0.3	-0.5	0.7	0.9