Hub : Genes

LOC100910615

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC100910615	0.07	0.05	1.6e-07	0.07	0.06	0.06	0.06	5.5e-07	1.0e-06	2.6e-06	1.5e-06
2	PL	gene expression	LOC100910615	0.07	0.05	1.2e-09	0.08	0.09	0.08	0.08	8.7e-09	8.4e-10	4.2e-09	3.1e-09
3	OFC	gene expression	LOC100910615	0.68	0.19	6.9e-04	0.13	0.11	0.12	0.13	4.5e-04	1.4e-03	7.3e-04	6.2e-04
4	NAcc	gene expression	LOC100910615	0.11	0.07	3.4e-15	0.14	0.14	0.14	0.14	4.5e-16	1.4e-15	1.6e-16	8.9e-16

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.5	0.8	1.1	1.1	-1.0	0.8	0.8
Area under the delay curve	0.7	0.8	1.2	-1.1	1.0	-0.8	-0.5
BMI with tail	1.7	5.4	6.7	-2.6	2.6	-2.3	-1.7
BMI without tail	1.1	2.2	3.0	-1.7	1.7	-1.4	-0.9
Body weight	5.9	24.6	27.9	-5.3	5.3	-5.1	-4.1
Weight adjusted by age	0.8	1.0	1.5	-0.9	1.2	-1.1	-0.6
Bone surface	0.0	0.0	0.1	0.2	0.0	-0.1	0.3
Bone volume	0.0	0.0	0.0	0.0	0.1	-0.2	-0.1
Breakpoint value in progressive ratio session	0.2	0.3	0.3	0.5	-0.6	0.5	0.4
Number of licking bursts	0.5	0.6	0.7	0.8	-0.8	0.7	0.7
Context. condit. distance diff. score	0.3	0.3	0.6	0.4	-0.6	0.7	0.5
Locomotion velocity, session 1	0.5	0.6	0.7	0.8	-0.8	0.8	0.6
Locomotion distance, session 1	3.3	4.2	4.8	2.2	-2.1	2.1	1.8
Locomotion velocity, session 2	0.2	0.3	0.3	0.5	-0.5	0.5	0.5
Locomotion distance, session 2	0.8	1.2	1.3	1.2	-1.1	1.1	0.9
Locomotion velocity, session 3	0.5	0.6	0.7	-0.7	0.7	-0.8	-0.8
Locomotion distance, session 3	0.2	0.2	0.3	0.5	-0.5	0.5	0.3
Stereotopy head waving bouts, day 3	2.0	2.4	2.7	-1.6	1.5	-1.5	-1.5
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.4	0.4	-0.3	-0.2
Locomotion velocity, session 7	0.0	0.0	0.1	0.1	-0.2	0.1	-0.3
Locomotion distance, session 7	0.6	0.8	1.1	0.9	-1.1	1.0	0.4
Stereotopy head waving bouts, day 7	0.5	0.5	0.6	-0.7	0.7	-0.8	-0.7
Stereotopy head waving duration, day 7	1.3	1.5	1.9	-1.2	1.2	-1.4	-1.1
Locomotion velocity, session 8	0.0	0.0	0.0	-0.0	-0.1	0.1	-0.0
Locomotion distance, session 8	0.8	1.2	1.4	1.1	-1.1	1.2	1.0
Degree of sensitization distance	0.0	0.0	0.0	0.0	-0.1	0.1	0.0
Degree of sensitization stereotypy	0.0	0.0	0.0	-0.0	0.0	-0.2	-0.2
Conditioned locomotion	2.8	3.3	3.6	-1.9	1.8	-1.8	-1.7
Cocaine response after cond. corrected	0.5	0.5	0.9	-0.8	0.9	-0.7	-0.4
Cocaine response after cond. not corrected	0.5	0.6	0.9	-0.9	0.9	-0.7	-0.4
Cocaine response before conditioning	0.0	0.0	0.1	-0.2	-0.0	-0.0	-0.3
Saline control response	0.7	0.9	1.2	-1.1	0.9	-0.8	-0.9
Bone: connectivity density	0.5	0.8	1.1	1.0	-0.8	0.7	0.9
Bone: cortical apparent density	0.0	0.0	0.0	0.0	-0.0	-0.1	-0.2
Bone: cortical area	0.2	0.3	0.5	-0.7	0.7	-0.4	-0.1
Bone: cortical porosity	0.0	0.0	0.0	-0.0	0.0	0.0	0.1
Bone: cortical porosity	0.0	0.0	0.0	0.0	-0.0	0.1	0.1
Bone: cortical thickness	0.1	0.1	0.2	0.2	-0.3	0.5	0.5
Bone: cortical thickness	0.0	0.1	0.1	-0.3	0.1	-0.1	-0.4
Bone: cortical tissue density	0.0	0.0	0.1	-0.0	0.1	-0.2	-0.2
Condit. Reinf. active minus inactive responses	0.9	1.0	1.2	1.1	-1.0	0.9	0.9
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	0.4	-0.2	0.3	0.4
Condit. Reinf. active responses	0.1	0.2	0.3	0.5	-0.5	0.3	0.3
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.4	-0.5	0.3	0.1
Incentive salience index mean	0.3	0.4	0.5	0.7	-0.6	0.5	0.6
Condit. Reinf. lever presses	0.0	0.1	0.1	0.3	-0.2	0.2	0.3
Condit. Reinf. active minus inactive responses	0.6	0.8	1.1	1.0	-1.0	0.8	0.7
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.6	0.8	-0.5	0.4	0.5
Condit. Reinf. active responses	0.5	0.8	0.9	1.0	-1.0	0.9	0.6
Condit. Reinf. inactive responses	0.1	0.1	0.1	-0.3	0.1	-0.1	-0.4
Condit. Reinf. lever presses	3.3	4.5	5.6	2.1	-2.3	2.4	1.6
Condit. Reinf. lever reinforcers received	1.2	1.7	2.0	1.4	-1.4	1.4	1.0
Conditioned reinforcement - actives	0.6	0.6	0.6	-0.8	0.8	-0.8	-0.8
Conditioned reinforcement - inactives	0.1	0.1	0.2	0.2	-0.4	0.3	0.1
Conditioned locomotion	0.6	0.7	0.8	-0.9	0.9	-0.8	-0.8
Patch foraging indifference point 0 sec	0.3	0.5	0.6	-0.8	0.7	-0.7	-0.8
Patch foraging indifference point AUC	0.0	0.0	0.0	0.1	-0.2	0.1	-0.1
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.2	0.4	-0.0	0.2
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	-0.5	0.4	-0.3	-0.2
Delay disc. indifference point, 2s delay	0.2	0.2	0.4	0.2	-0.2	0.5	0.6
Delay disc. indifference point, 24s delay	2.2	2.1	2.7	-1.6	1.6	-1.5	-1.0
Delay disc. indifference point, 4s delay	1.0	1.0	1.4	-1.2	1.2	-0.9	-0.7
Delay disc. indifference point, 8s delay	1.8	1.9	2.4	-1.6	1.4	-1.3	-1.2
Indifference point function ln k	0.1	0.2	0.2	0.5	-0.3	0.4	0.4
Indifference point function log k	0.1	0.2	0.2	0.5	-0.3	0.4	0.4
Patch foraging total patch changes 0 sec	0.3	0.4	0.6	-0.7	0.6	-0.6	-0.8
Patch foraging total patch changes 12 sec	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.3
Patch foraging total patch changes 18 sec	0.8	1.0	1.5	-1.1	0.8	-0.9	-1.2
Patch foraging total patch changes 24 sec	0.3	0.4	0.6	0.7	-0.7	0.8	0.4
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	-0.2	0.2	-0.1	-0.2
Patch foraging time to switch 0 sec	0.8	1.3	1.9	-1.2	1.4	-1.1	-0.8
Patch foraging water rate 0 sec	0.1	0.2	0.4	0.6	-0.6	0.4	0.1
Patch foraging water rate 12 sec	0.1	0.2	0.3	0.6	-0.5	0.4	0.3
Patch foraging water rate 18 sec	0.5	0.6	0.8	0.9	-0.9	0.8	0.5
Patch foraging water rate 24 sec	0.3	0.4	0.6	0.6	-0.7	0.8	0.4
Patch foraging water rate 6 sec	0.1	0.2	0.3	0.3	-0.5	0.5	0.2
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	-0.1	-0.0	-0.2	-0.3
Distance traveled before self-admin	0.8	0.8	0.9	-1.0	0.9	-1.0	-0.7
Distance traveled after self-admin	0.1	0.1	0.2	-0.3	0.2	-0.5	-0.2
Extensor digitorum longus weight	0.1	0.6	0.8	0.7	-0.9	0.9	0.5
Bone: elastic displacement	0.0	0.0	0.1	0.2	-0.2	0.2	0.2
Bone: elastic work	0.0	0.0	0.0	-0.2	0.1	-0.0	0.1
Bone: endosteal estimation	3.1	6.7	7.7	-2.7	2.8	-2.7	-2.2
Bone: endosteal perimeter	1.5	3.1	4.1	-1.8	2.0	-1.9	-1.2
Epididymis fat weight	1.3	3.1	3.7	-1.9	1.9	-1.8	-1.4
Delta time in closed arm before/after self-admin	1.4	1.4	1.8	-1.3	1.3	-1.2	-0.8
Delta time in open arm before/after self-admin	0.8	0.7	0.8	0.9	-0.9	0.9	0.7
Diff in mean of infusions in LGA sessions	0.9	1.0	1.2	1.1	-1.0	0.9	0.8
Delay discount exponential model param	0.6	0.6	1.0	1.0	-0.9	0.7	0.5
Extinction: sum of active levers before priming	0.2	0.2	0.2	0.4	-0.4	0.5	0.5
Active lever presses in extinction session 6	0.0	0.0	0.0	0.0	0.1	-0.0	-0.0
Bone: final force	3.9	6.3	7.4	-2.7	2.7	-2.6	-2.0
Bone: final moment	3.3	5.3	6.4	-2.5	2.5	-2.3	-1.9
Food consumed during 24 hour testing period	0.4	0.4	0.6	-0.7	0.7	-0.6	-0.5
Glucose	0.0	0.0	0.1	-0.0	0.1	0.2	0.3
Heart weight	2.6	3.6	4.3	1.9	-1.8	1.9	2.1
Delay discount hyperbolic model param	0.3	0.4	0.6	0.8	-0.7	0.5	0.3
Intermittent access intake day 1-15 change	1.0	1.0	1.3	-1.0	0.8	-1.1	-1.0
Intermittent access intake escalation	1.6	1.5	1.9	-1.2	1.1	-1.4	-1.2
Intermittent access intake escalation 2	0.0	0.0	0.1	0.1	-0.2	-0.2	-0.3
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.1	0.2	-0.2	0.3	0.3
Intermitt. access day 15 inactive lever presses	1.5	1.6	1.9	-1.3	1.2	-1.4	-1.2
Intermitt. access escalation Index	0.5	0.4	0.5	0.7	-0.6	0.6	0.6
Intermittent access day 1 total infusions	0.2	0.3	0.3	0.5	-0.6	0.6	0.4
Intermittent access day 15 total infusions	0.1	0.1	0.2	-0.4	0.3	-0.4	-0.4
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.3	-0.5	0.5	-0.6	-0.5
Intermittent access total infusions	0.0	0.0	0.0	0.1	-0.2	0.1	0.1
Intermittent access day 1 locomotion	0.2	0.2	0.3	-0.5	0.4	-0.4	-0.4
Intermittent access day 15 total locomotion	5.2	5.6	6.4	-2.5	2.3	-2.5	-2.1
Intermittent access total locomotion	2.0	2.3	2.8	-1.7	1.4	-1.6	-1.4
Intermittent access standard deviation	1.0	1.0	1.1	-1.0	1.0	-1.0	-1.0
Left kidney weight	2.9	8.3	9.7	-2.9	3.0	-3.1	-2.5
Right kidney weight	3.8	10.7	11.6	-3.4	3.4	-3.4	-2.9
Cocaine induced anxiety	0.0	0.0	0.1	0.1	-0.3	0.1	-0.2
Post-drug Anxiety	0.2	0.2	0.3	0.5	-0.6	0.4	0.2
Baseline Anxiety	0.3	0.4	0.5	0.6	-0.4	0.6	0.7
Tail length	1.1	3.5	3.9	-2.0	1.9	-1.9	-1.6
Length with tail	2.4	8.9	10.3	-3.0	3.0	-3.2	-2.7
Length without tail	1.8	4.0	4.7	-1.9	2.0	-2.2	-1.8
Times rat made contact with spout	2.5	2.9	3.6	1.8	-1.9	1.7	1.3
Lifetime Intake	0.1	0.1	0.1	-0.3	0.2	-0.3	-0.3
Liver weight, left	5.9	9.4	10.6	-3.3	2.9	-3.1	-3.0
Liver weight, right	2.9	4.8	5.2	-2.3	2.0	-2.2	-2.2
Locomotor activity	0.2	0.3	0.5	-0.6	0.4	-0.4	-0.7
Locomotor testing distance	0.0	0.0	0.0	-0.2	0.0	0.1	-0.1
Locomotor testing rearing	1.0	1.5	2.0	-1.4	1.2	-1.1	-1.1
Locomotion in novel chamber	0.5	0.7	1.0	0.7	-0.8	1.0	0.8
Locomotion in novel chamber post-restriction	1.8	2.1	2.4	-1.5	1.6	-1.4	-1.3
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	-0.1	0.1	-0.0	-0.1
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.3	0.5	-0.1	0.1
Time >=10cm from walls, locomotor time 1	1.4	1.4	1.7	-1.1	1.3	-1.3	-1.0
Bouts of movement, locomotor time 1	0.2	0.2	0.3	0.5	-0.5	0.5	0.4
Total resting periods, locomotor time 1	0.0	0.0	0.1	0.1	-0.2	0.3	0.1
Rest time, locomotor task time 1	0.1	0.1	0.2	-0.3	0.4	-0.3	-0.3
Distance moved, locomotor task time 1	0.1	0.1	0.1	-0.3	0.3	-0.4	-0.2
Vertical activity count, locomotor time 1	0.5	0.6	0.8	-0.7	0.8	-0.9	-0.6
Time >=10cm from walls, locomotor time 2	5.2	5.5	6.9	-2.4	2.6	-2.4	-1.9
Bouts of movement, locomotor time 2	0.1	0.1	0.2	-0.3	0.3	-0.3	-0.4
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.2	-0.1	0.3	0.1
Rest time, locomotor task time 2	0.0	0.0	0.1	-0.1	0.1	0.2	0.3
Distance moved, locomotor task time 2	2.3	2.7	3.2	-1.6	1.6	-1.8	-1.6
Vertical activity count, locomotor time 2	1.5	1.6	2.4	-1.1	1.2	-1.6	-1.2
Light reinforcement 1	2.0	3.7	3.9	-2.0	1.9	-1.9	-1.8
Light reinforcement 2	2.4	3.2	3.4	-1.8	1.8	-1.8	-1.6
Bone: marrow area	3.2	6.9	7.9	-2.8	2.8	-2.7	-2.2
Bone: maximum diameter	0.3	0.5	0.9	-0.8	0.9	-0.7	-0.2
Bone: maximum force	1.4	2.4	3.0	-1.6	1.7	-1.6	-1.2
Bone: maximum moment	1.0	1.8	2.2	-1.5	1.5	-1.3	-1.0
Mean time between licks in bursts	0.6	0.8	1.2	1.1	-0.9	0.8	0.9
Mean num. licks in bursts	0.2	0.2	0.2	0.5	-0.5	0.5	0.2
Cd content in liver	1.1	1.2	1.5	-1.1	1.1	-1.2	-1.1
Co content in liver	2.0	2.4	2.8	-1.5	1.7	-1.6	-1.3
Cu content in liver	3.3	4.0	4.7	2.2	-2.1	2.0	1.7
Fe content in liver	4.0	4.8	5.9	-2.1	2.3	-2.4	-1.9
K content in liver	1.3	1.3	1.9	1.4	-1.1	0.9	1.1
Mg content in liver	2.7	2.8	3.4	1.8	-1.6	1.6	1.6
Mn content in liver	0.1	0.1	0.2	0.5	-0.3	0.2	0.4
Na content in liver	0.1	0.1	0.2	0.5	-0.3	-0.0	0.2
Rb content in liver	0.1	0.2	0.2	-0.5	0.4	-0.3	-0.3
Se content in liver	2.8	3.5	4.5	2.1	-1.9	1.7	1.8
Sr content in liver	0.0	0.0	0.1	0.1	-0.1	0.3	0.2
Zn content in liver	0.6	0.7	1.5	-1.2	1.0	-0.4	-0.4
Bone: minimum diameter	1.0	1.8	2.7	-1.5	1.6	-1.3	-0.7
Time in familiar zone, hab. session 1	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1
Time in novel zone, hab. session 1	0.2	0.2	0.3	-0.4	0.6	-0.6	-0.3
Total zone transitions, hab. session 1	2.3	3.2	3.8	1.9	-2.0	1.8	1.4
Total locomotion distance, hab. session 1	1.7	2.4	2.7	1.6	-1.7	1.6	1.3
Locomotion velocity, hab. session 1	1.6	2.2	2.6	1.5	-1.6	1.6	1.3
Time in familiar zone, hab. session 2	1.2	1.2	1.6	1.0	-1.2	1.3	0.9
Time in novel zone, hab. session 2	1.4	1.4	1.7	-1.1	1.3	-1.3	-1.0
Total zone transitions, hab. session 2	0.4	0.5	0.6	0.8	-0.7	0.7	0.6
Total locomotion distance, hab. session 2	2.3	3.0	3.3	1.8	-1.8	1.8	1.5
Locomotion velocity, hab. session 2	2.7	3.6	4.0	2.0	-2.0	2.0	1.6
Novel to familiar place preference ratio	0.3	0.3	0.4	-0.6	0.6	-0.5	-0.3
Novelty place preference	0.2	0.2	0.3	-0.6	0.6	-0.5	-0.3
Time in novel zone, NPP test	0.3	0.3	0.4	-0.6	0.6	-0.6	-0.4
Total zone transitions, NPP test	1.6	2.3	2.6	1.6	-1.5	1.6	1.3
Total locomotion distance, NPP test	1.3	1.7	2.1	1.3	-1.4	1.5	1.1
Locomotion velocity, NPP test	1.9	2.7	3.2	1.7	-1.7	1.8	1.4
Intraocular pressure	1.0	1.5	1.7	-1.2	1.3	-1.2	-1.1
Delta distance traveled before/after self-admin	0.4	0.5	0.6	0.8	-0.8	0.6	0.6
Delta ambulatory time before/after self-admin	0.5	0.6	0.8	0.8	-0.9	0.7	0.6
Parametrial fat weight	2.1	4.2	4.9	-2.2	1.9	-2.0	-2.0
Pavlov. Cond. lever latency	0.4	0.5	0.6	-0.8	0.7	-0.6	-0.7
Pavlov. Cond. magazine entry latency	0.5	0.6	0.9	0.8	-0.7	0.9	0.7
Pavlov. Cond. change in total contacts	0.4	0.5	0.6	-0.7	0.8	-0.7	-0.6
Pavlov. Cond. index score	0.2	0.2	0.3	0.5	-0.4	0.6	0.5
Pavlov. Cond. latency score	0.1	0.2	0.2	0.4	-0.3	0.5	0.4
Pavlov. Cond. lever contacts	0.3	0.3	0.4	0.6	-0.5	0.6	0.6
Pavlov. Cond. magazine entry number	1.1	1.3	1.5	-1.2	1.1	-1.2	-1.1
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	0.4	-0.3	0.5	0.4
Pavlov. Cond. response bias	1.0	1.2	1.4	1.2	-1.1	1.2	1.0
Pavlov. Cond. lever latency	1.7	2.3	3.2	-1.5	1.7	-1.8	-1.0
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	-0.5	0.4	-0.5	-0.5
Pavlov. Cond. change in total contacts	1.1	1.5	2.0	1.3	-1.4	1.4	0.8
Pavlov. Cond. index score	0.4	0.5	0.7	0.7	-0.8	0.8	0.3
Pavlov. Cond. latency score	0.2	0.2	0.4	0.5	-0.6	0.6	0.2
Pavlov. Cond. lever contacts	1.1	1.5	2.1	1.2	-1.4	1.5	0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	0.3	-0.1	0.2	0.4
Pavlov. Cond. intertrial magazine entries	0.5	0.7	1.1	1.0	-0.8	0.7	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	0.4	-0.6	0.5	0.1
Pavlov. Cond. response bias	0.6	0.8	1.2	0.8	-1.1	1.0	0.3
Time in closed arm before self-admin	0.3	0.4	0.6	0.8	-0.6	0.6	0.5
Time in closed arm after self-admin	0.1	0.1	0.1	-0.1	0.3	-0.3	-0.2
Time in open arm before self-admin	0.1	0.2	0.3	0.3	-0.6	0.4	0.2
Time in open arm after self-admin	1.6	1.8	2.2	1.3	-1.5	1.4	1.1
Bone: periosteal estimation	1.9	3.9	4.9	-2.1	2.2	-2.0	-1.5
Bone: periosteal perimeter	0.6	1.0	1.6	-1.1	1.3	-1.0	-0.5
Bone: post-yield work	0.2	0.2	0.3	-0.4	0.6	-0.6	-0.3
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	0.0	-0.1	0.2	0.1
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	0.1	-0.1	0.2	0.2
Progressive ratio test 1 inactive lever presses	0.9	1.0	1.2	-1.1	1.0	-1.0	-0.9
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.3	0.4	-0.5	0.2	0.1
Incentive Sensitization - Responses	0.8	0.8	1.0	1.0	-1.0	0.9	0.7
Incentive Sensitization - Breakpoint	0.4	0.4	0.5	0.7	-0.7	0.6	0.5
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.4	0.6	-0.6	0.5	0.7
Progressive ratio	3.5	4.0	4.5	-2.0	1.9	-2.1	-2.0
Food seeking constrained by brief footshock	0.1	0.1	0.1	0.4	-0.3	0.3	0.4
Seeking ratio, punishment vs. effort	2.5	3.0	3.4	1.8	-1.6	1.8	1.8
Retroperitoneal fat weight	1.3	4.1	4.8	-2.2	2.1	-2.0	-1.8
Reaction time number correct	0.7	1.0	1.4	-1.0	0.9	-1.0	-1.2
Reaction time mean minus median	0.2	0.2	0.3	-0.4	0.4	-0.5	-0.6
Reaction time mean minus median AUC	0.1	0.2	0.2	-0.4	0.4	-0.4	-0.5
Reaction time num false alarms	0.0	0.1	0.2	0.2	-0.4	0.3	-0.1
Reaction time num false alarms AUC	0.4	0.6	0.9	0.7	-1.0	0.8	0.4
Reaction time trials correct on left	0.7	1.0	1.4	-1.0	0.9	-1.0	-1.2
Reaction time trials on left	0.7	1.0	1.3	-1.0	0.9	-0.9	-1.2
Reaction time mean	0.2	0.2	0.3	-0.5	0.6	-0.4	-0.4
Reaction time mean AUC	0.5	0.6	0.7	-0.8	0.9	-0.7	-0.7
Median of all reaction times	0.2	0.2	0.4	-0.5	0.6	-0.4	-0.4
Reaction time omissions	0.0	0.0	0.1	-0.0	0.1	-0.2	-0.3
Reaction time false alarm rate	1.2	1.6	1.9	1.3	-1.4	1.3	1.2
Reaction time premature initiation rate	0.1	0.1	0.2	0.5	-0.4	0.3	0.3
Reaction time premature initiations	0.1	0.1	0.3	-0.2	0.2	-0.4	-0.5
Std. dev. reaction times	0.0	0.0	0.1	-0.1	0.1	-0.2	-0.2
Reaction time trials completed	0.7	1.0	1.3	-1.0	0.9	-0.9	-1.2
Reaction time trials AUC	0.6	0.9	1.3	-0.9	0.9	-0.9	-1.1
Run reversals in cocaine runway, females	0.2	0.2	0.3	-0.6	0.4	-0.3	-0.4
Run reversals in cocaine runway, males	0.4	0.4	0.7	-0.6	0.2	-0.7	-0.8
Latency to leave start box in cocaine runway	0.7	0.7	1.1	1.1	-0.6	0.7	1.0
Latency to leave start box in cocaine runway, F	0.6	0.7	1.1	1.0	-0.6	0.7	0.9
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.2	-0.0	0.1	0.3
Std. dev. time between licks in bursts	0.1	0.1	0.3	-0.5	0.6	-0.2	0.2
Total sessions with >9 infusions	0.0	0.0	0.0	-0.2	0.1	0.0	-0.1
Short access day 1 total inactive lever presses	0.0	0.0	0.1	0.3	-0.2	0.1	0.2
Short access day 10 total inactive lever presses	0.1	0.1	0.1	-0.3	0.1	-0.1	-0.3
Short access day 1 total infusions	0.8	0.9	1.1	0.9	-1.0	1.0	0.7
Short access day 10 total infusions	0.0	0.0	0.0	0.0	-0.1	0.0	0.0
Short access total infusions	0.0	0.0	0.0	-0.1	0.1	-0.0	-0.1
Short access day 1 locomotion	0.1	0.1	0.2	0.1	-0.2	0.4	0.2
Short access day 10 total locomotion	0.4	0.5	0.6	0.6	-0.6	0.8	0.7
Short access total locomotion	0.0	0.0	0.0	-0.1	0.1	0.0	0.0
One hour access (0.3 mA shock)	0.7	0.8	1.0	1.0	-1.0	0.9	0.6
Compulsive drug intake	3.0	3.0	3.3	1.8	-1.6	1.7	1.7
One hour access (shock baseline)	0.3	0.4	0.6	-0.6	0.4	-0.6	-0.8
Social response proportion	0.0	0.0	0.0	-0.0	0.1	0.0	0.1
Social responses	0.0	0.0	0.1	0.1	-0.2	0.3	0.1
Social time	0.1	0.2	0.2	0.5	-0.5	0.4	0.2
Soleus weight	0.2	0.6	0.9	-0.9	1.0	-0.8	-0.4
Bone: stiffness	1.1	1.8	2.2	-1.4	1.5	-1.3	-1.1
Tibialis anterior weight	0.8	2.8	3.3	1.7	-1.7	1.8	1.4
Time to tail flick, vehicle, before self-admin	2.3	2.4	2.7	-1.6	1.4	-1.6	-1.5
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.2	0.4	-0.3	0.5	0.5
Time to tail flick, test, before self-admin	0.1	0.1	0.1	0.3	-0.3	0.2	0.1
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.1	-0.1	-0.2	-0.4
Delta time to tail flick, vehicle, before/after SA	1.5	1.5	1.9	1.3	-1.1	1.4	1.2
Delta time to tail flick, test, before/after SA	1.5	1.4	1.6	-1.3	1.2	-1.1	-1.1
Tibia length	2.6	7.2	8.8	-2.6	2.8	-3.0	-2.3
Ambulatory time before self-admin	0.4	0.4	0.5	-0.6	0.6	-0.7	-0.5
Ambulatory time after self-admin	0.1	0.1	0.2	0.2	-0.4	0.1	0.2
Bone: tissue strength	0.0	0.0	0.0	-0.0	-0.0	0.0	-0.1
Total heroin consumption	0.3	0.3	0.7	0.6	-0.8	0.4	0.3
Bone: trabecular number	1.0	1.5	1.8	1.3	-1.3	1.2	1.1
Bone: trabecular spacing	1.9	2.5	3.1	-1.8	1.6	-1.5	-1.4
Bone: trabecular thickness	0.4	0.4	0.5	-0.6	0.6	-0.7	-0.7
Bone: trabecular tissue density	0.1	0.1	0.2	-0.1	0.2	-0.3	-0.4
Water consumed over 24 hours	1.4	1.7	1.8	1.3	-1.3	1.3	1.3
Number of responses in last shaping day	1.0	1.0	1.4	1.0	-0.8	1.0	1.2