Hub : Genes

LOC100359681

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression LOC100359681 0.11 0.11 2.9e-07 0.07 0.06 0.06 0.07 4.3e-08 1.1e-06 1.5e-07 9.6e-08
2 BLA gene expression LOC100359681 0.04 0.04 6.6e-03 0.02 0.03 0.02 0.02 1.8e-02 1.4e-02 2.9e-02 2.7e-02
3 Brain gene expression LOC100359681 0.04 0.03 4.0e-04 0.03 0.03 0.03 0.02 3.6e-04 1.5e-03 1.2e-03 2.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.30.40.70.8-0.80.3
Area under the delay curve0.60.71.00.7-0.71.0
BMI with tail0.30.90.9-0.91.0-1.0
BMI without tail0.00.10.10.3-0.30.3
Body weight2.39.410.23.2-3.22.8
Weight adjusted by age0.10.10.2-0.10.1-0.5
Bone surface1.22.22.71.6-1.61.1
Bone volume1.01.82.31.4-1.51.0
Breakpoint value in progressive ratio session3.43.74.52.0-1.62.1
Number of licking bursts4.14.85.2-2.32.1-2.2
Context. condit. distance diff. score0.00.00.0-0.20.10.0
Locomotion velocity, session 10.60.60.7-0.70.8-0.8
Locomotion distance, session 10.40.50.70.8-0.80.6
Locomotion velocity, session 20.30.30.5-0.50.7-0.5
Locomotion distance, session 21.31.82.2-1.21.3-1.5
Locomotion velocity, session 30.40.40.5-0.70.6-0.7
Locomotion distance, session 33.23.53.51.9-1.91.9
Stereotopy head waving bouts, day 30.70.91.3-0.80.9-1.1
Stereotopy head waving duration, day 31.61.92.3-1.31.4-1.5
Locomotion velocity, session 70.20.30.40.6-0.60.3
Locomotion distance, session 70.10.10.10.4-0.40.1
Stereotopy head waving bouts, day 70.91.01.1-1.01.0-0.9
Stereotopy head waving duration, day 72.32.83.0-1.71.7-1.6
Locomotion velocity, session 84.25.05.6-2.12.2-2.4
Locomotion distance, session 80.71.01.0-1.01.0-1.0
Degree of sensitization distance0.70.70.8-0.80.8-0.9
Degree of sensitization stereotypy1.21.41.4-1.21.2-1.1
Conditioned locomotion0.30.40.6-0.50.7-0.6
Cocaine response after cond. corrected0.00.00.1-0.20.20.1
Cocaine response after cond. not corrected0.00.00.0-0.10.10.1
Cocaine response before conditioning1.11.31.61.3-1.30.8
Saline control response0.00.00.10.1-0.10.3
Bone: connectivity density0.10.20.30.6-0.60.0
Bone: cortical apparent density2.22.93.0-1.71.7-1.7
Bone: cortical area1.31.92.11.4-1.41.3
Bone: cortical porosity1.71.92.6-1.21.3-1.6
Bone: cortical porosity2.22.43.0-1.41.5-1.7
Bone: cortical thickness0.20.40.40.6-0.70.6
Bone: cortical thickness0.91.01.1-0.91.0-1.1
Bone: cortical tissue density2.63.43.6-1.81.8-1.9
Condit. Reinf. active minus inactive responses0.10.10.2-0.40.5-0.1
Condit. Reinf. active-inactive response ratio0.10.10.2-0.40.4-0.2
Condit. Reinf. active responses1.72.12.6-1.51.6-1.2
Condit. Reinf. inactive responses1.82.12.6-1.41.6-1.4
Incentive salience index mean0.10.10.2-0.40.40.0
Condit. Reinf. lever presses0.10.10.20.2-0.20.5
Condit. Reinf. active minus inactive responses2.63.24.51.6-1.62.1
Condit. Reinf. active-inactive response ratio0.10.10.3-0.20.10.5
Condit. Reinf. active responses4.56.26.72.4-2.42.6
Condit. Reinf. inactive responses4.65.76.52.5-2.52.1
Condit. Reinf. lever presses8.611.711.83.4-3.43.4
Condit. Reinf. lever reinforcers received4.56.46.92.5-2.52.6
Conditioned reinforcement - actives0.20.20.3-0.50.4-0.4
Conditioned reinforcement - inactives0.60.60.70.8-0.80.7
Conditioned locomotion1.72.12.6-1.11.6-1.6
Patch foraging indifference point 0 sec0.10.10.20.4-0.40.1
Patch foraging indifference point AUC0.40.40.6-0.30.7-0.8
Delay disc. indifference point, 0s delay0.30.40.70.5-0.40.8
Delay disc. indifference point, 16s delay1.91.92.61.3-1.21.6
Delay disc. indifference point, 2s delay0.91.01.11.0-1.00.9
Delay disc. indifference point, 24s delay2.92.83.01.6-1.61.7
Delay disc. indifference point, 4s delay0.00.00.0-0.20.00.2
Delay disc. indifference point, 8s delay0.20.20.30.3-0.50.5
Indifference point function ln k0.60.81.30.7-0.81.1
Indifference point function log k0.60.81.30.7-0.81.1
Patch foraging total patch changes 0 sec0.10.20.30.5-0.60.3
Patch foraging total patch changes 12 sec0.00.00.10.3-0.20.2
Patch foraging total patch changes 18 sec0.20.20.6-0.20.2-0.7
Patch foraging total patch changes 24 sec0.50.60.90.8-0.90.7
Patch foraging total patch changes 6 sec0.00.10.10.2-0.1-0.4
Patch foraging time to switch 0 sec0.40.71.2-1.10.7-0.5
Patch foraging water rate 0 sec0.81.42.1-0.91.1-1.4
Patch foraging water rate 12 sec0.30.40.50.7-0.70.5
Patch foraging water rate 18 sec0.20.30.5-0.40.5-0.7
Patch foraging water rate 24 sec0.00.00.0-0.2-0.0-0.2
Patch foraging water rate 6 sec0.71.01.21.0-1.10.9
Seeking ratio, delayed vs. immediate footshock0.91.01.40.5-1.21.2
Distance traveled before self-admin0.20.20.60.1-0.30.8
Distance traveled after self-admin4.75.25.32.3-2.32.3
Extensor digitorum longus weight0.20.80.9-1.00.9-0.9
Bone: elastic displacement0.00.00.10.10.0-0.3
Bone: elastic work1.82.32.51.6-1.51.4
Bone: endosteal estimation1.73.74.02.0-2.01.8
Bone: endosteal perimeter1.83.84.11.9-1.92.0
Epididymis fat weight0.00.00.10.2-0.2-0.0
Delta time in closed arm before/after self-admin2.42.42.51.5-1.61.5
Delta time in open arm before/after self-admin1.31.21.4-1.11.0-1.2
Diff in mean of infusions in LGA sessions0.10.10.10.10.20.4
Delay discount exponential model param0.70.71.0-0.70.8-1.0
Extinction: sum of active levers before priming4.24.24.62.2-1.92.1
Active lever presses in extinction session 63.73.64.02.0-1.81.9
Bone: final force1.52.42.71.6-1.61.4
Bone: final moment2.03.23.51.8-1.91.7
Food consumed during 24 hour testing period0.81.01.11.0-1.00.9
Glucose0.20.30.4-0.60.6-0.6
Heart weight0.20.30.30.5-0.50.6
Delay discount hyperbolic model param0.50.50.7-0.60.7-0.8
Intermittent access intake day 1-15 change1.61.61.91.3-1.41.1
Intermittent access intake escalation1.51.51.91.2-1.41.0
Intermittent access intake escalation 21.41.41.80.9-1.31.2
Intermitt. access day 1 inactive lever presses4.34.65.32.0-2.12.3
Intermitt. access day 15 inactive lever presses0.50.61.00.4-0.81.0
Intermitt. access escalation Index0.10.10.1-0.20.3-0.3
Intermittent access day 1 total infusions2.22.52.8-1.71.6-1.5
Intermittent access day 15 total infusions0.00.00.1-0.40.1-0.1
Intermittent access terminal intake (last 3 days)0.20.20.5-0.70.3-0.2
Intermittent access total infusions0.40.50.7-0.80.6-0.5
Intermittent access day 1 locomotion0.70.70.8-0.90.9-0.8
Intermittent access day 15 total locomotion0.00.00.10.10.1-0.3
Intermittent access total locomotion0.91.01.1-0.91.1-1.0
Intermittent access standard deviation5.86.26.42.5-2.52.4
Left kidney weight1.95.46.22.4-2.52.1
Right kidney weight4.412.313.13.6-3.63.3
Cocaine induced anxiety0.70.80.90.9-0.80.9
Post-drug Anxiety0.00.00.1-0.10.00.3
Baseline Anxiety1.51.62.2-1.51.2-1.2
Tail length4.814.715.13.9-3.93.7
Length with tail7.929.030.55.5-5.55.1
Length without tail4.49.711.13.3-3.32.7
Times rat made contact with spout1.11.31.8-1.11.0-1.3
Lifetime Intake0.70.81.2-1.10.8-0.8
Liver weight, left0.71.11.3-1.00.9-1.1
Liver weight, right0.10.20.3-0.30.4-0.5
Locomotor activity0.50.71.1-0.60.8-1.1
Locomotor testing distance0.40.70.9-0.70.8-1.0
Locomotor testing rearing2.84.44.8-2.21.9-2.2
Locomotion in novel chamber0.00.00.0-0.10.20.1
Locomotion in novel chamber post-restriction0.40.51.10.3-0.51.0
Fecal boli incidents, locomotor time 10.91.01.5-0.81.2-1.0
Change in fecal boli incidents, locomotor task0.10.10.20.1-0.30.4
Time >=10cm from walls, locomotor time 10.10.10.2-0.50.2-0.1
Bouts of movement, locomotor time 11.11.21.61.3-0.91.0
Total resting periods, locomotor time 11.11.21.61.3-0.91.1
Rest time, locomotor task time 10.20.30.7-0.20.8-0.3
Distance moved, locomotor task time 10.10.10.3-0.50.0-0.4
Vertical activity count, locomotor time 11.11.11.61.0-1.30.9
Time >=10cm from walls, locomotor time 21.21.31.5-1.21.2-1.0
Bouts of movement, locomotor time 20.00.00.00.2-0.00.1
Total resting periods, locomotor time 20.00.00.00.10.1-0.0
Rest time, locomotor task time 20.10.10.3-0.20.5-0.2
Distance moved, locomotor task time 20.60.71.0-1.00.5-0.9
Vertical activity count, locomotor time 20.40.40.60.5-0.80.6
Light reinforcement 10.10.30.6-0.20.4-0.8
Light reinforcement 22.53.33.6-1.71.9-1.8
Bone: marrow area1.83.94.22.0-2.01.8
Bone: maximum diameter1.22.32.71.5-1.61.4
Bone: maximum force2.44.24.72.1-2.21.9
Bone: maximum moment3.05.15.52.3-2.32.2
Mean time between licks in bursts0.00.00.10.1-0.10.3
Mean num. licks in bursts1.21.41.61.3-1.21.1
Cd content in liver0.00.00.10.1-0.1-0.3
Co content in liver0.40.50.6-0.60.7-0.7
Cu content in liver0.30.30.50.6-0.70.3
Fe content in liver0.00.00.0-0.10.1-0.0
K content in liver0.00.00.10.2-0.20.2
Mg content in liver0.50.50.6-0.70.7-0.8
Mn content in liver0.91.01.4-0.81.0-1.2
Na content in liver2.02.13.21.1-1.41.8
Rb content in liver0.00.00.0-0.20.2-0.2
Se content in liver8.19.910.0-3.13.2-3.2
Sr content in liver0.70.60.8-0.80.9-0.8
Zn content in liver0.10.20.2-0.40.3-0.4
Bone: minimum diameter3.87.18.02.6-2.62.8
Time in familiar zone, hab. session 10.30.20.30.5-0.50.5
Time in novel zone, hab. session 11.11.01.2-1.11.0-1.0
Total zone transitions, hab. session 10.00.00.00.10.00.2
Total locomotion distance, hab. session 11.72.42.61.6-1.41.6
Locomotion velocity, hab. session 11.11.51.81.3-1.11.2
Time in familiar zone, hab. session 22.93.03.41.9-1.61.7
Time in novel zone, hab. session 21.91.92.2-1.51.3-1.4
Total zone transitions, hab. session 22.83.64.0-1.92.0-1.8
Total locomotion distance, hab. session 20.00.00.1-0.10.2-0.2
Locomotion velocity, hab. session 20.10.10.1-0.20.4-0.3
Novel to familiar place preference ratio0.10.10.10.1-0.40.3
Novelty place preference0.00.00.10.0-0.20.2
Time in novel zone, NPP test0.00.00.0-0.2-0.0-0.0
Total zone transitions, NPP test0.10.20.4-0.10.3-0.6
Total locomotion distance, NPP test2.43.43.92.0-1.91.6
Locomotion velocity, NPP test2.73.84.42.1-2.01.7
Intraocular pressure0.00.00.1-0.1-0.00.2
Delta distance traveled before/after self-admin4.34.65.52.3-2.21.8
Delta ambulatory time before/after self-admin4.54.96.52.5-2.31.7
Parametrial fat weight0.30.50.9-0.60.5-0.9
Pavlov. Cond. lever latency0.10.20.20.4-0.40.4
Pavlov. Cond. magazine entry latency0.40.60.7-0.80.7-0.8
Pavlov. Cond. change in total contacts0.20.20.3-0.50.5-0.2
Pavlov. Cond. index score0.50.60.6-0.80.8-0.8
Pavlov. Cond. latency score0.20.20.3-0.50.5-0.4
Pavlov. Cond. lever contacts0.10.10.10.3-0.20.3
Pavlov. Cond. magazine entry number0.60.80.80.9-0.80.9
Pavlov. Cond. intertrial magazine entries0.50.60.9-0.91.0-0.3
Pavlov. Cond. lever-magazine prob. diff.0.60.80.9-0.90.9-0.9
Pavlov. Cond. response bias0.10.10.2-0.40.4-0.4
Pavlov. Cond. lever latency5.47.27.3-2.72.7-2.7
Pavlov. Cond. magazine entry latency3.74.24.62.1-2.02.1
Pavlov. Cond. change in total contacts9.112.614.13.4-3.53.8
Pavlov. Cond. index score5.77.37.62.7-2.72.8
Pavlov. Cond. latency score5.56.97.32.6-2.62.7
Pavlov. Cond. lever contacts4.66.36.62.4-2.52.6
Pavlov. Cond. magazine entry number4.15.05.6-2.12.2-2.4
Pavlov. Cond. intertrial magazine entries1.62.13.2-1.31.2-1.8
Pavlov. Cond. lever-magazine prob. diff.5.46.97.22.6-2.62.7
Pavlov. Cond. response bias5.37.17.82.5-2.72.8
Time in closed arm before self-admin2.73.04.0-2.01.6-1.6
Time in closed arm after self-admin0.30.30.70.4-0.40.8
Time in open arm before self-admin4.85.26.02.4-2.32.1
Time in open arm after self-admin0.50.50.70.8-0.80.4
Bone: periosteal estimation2.04.24.52.1-2.11.9
Bone: periosteal perimeter1.83.13.41.8-1.61.8
Bone: post-yield work1.72.32.61.5-1.61.4
Progressive ratio test 1 active lever presses0.50.50.50.7-0.70.7
Progressive ratio test 1 breakpoint1.01.01.11.0-0.91.1
Progressive ratio test 1 inactive lever presses0.50.60.70.7-0.70.8
Progressive ratio test 2 active lever presses0.10.10.1-0.1-0.20.4
Progressive ratio test 2 breakpoint0.00.00.1-0.1-0.10.3
Progressive ratio test 2 inactive lever presses1.82.03.11.3-1.21.8
Incentive Sensitization - Responses0.10.10.2-0.40.20.1
Incentive Sensitization - Breakpoint0.10.10.2-0.40.20.1
Sum of active levers in priming session hrs 5-60.30.20.40.4-0.40.6
Progressive ratio0.00.00.1-0.0-0.20.3
Food seeking constrained by brief footshock3.74.55.21.9-2.22.3
Seeking ratio, punishment vs. effort0.60.70.80.8-0.90.8
Retroperitoneal fat weight1.86.07.1-2.32.4-2.7
Reaction time number correct0.10.20.4-0.20.3-0.6
Reaction time mean minus median0.20.30.50.5-0.70.2
Reaction time mean minus median AUC0.40.50.80.7-0.90.2
Reaction time num false alarms1.31.82.0-1.41.2-1.4
Reaction time num false alarms AUC1.41.92.2-1.41.3-1.5
Reaction time trials correct on left0.10.20.4-0.20.3-0.6
Reaction time trials on left0.10.20.4-0.20.3-0.6
Reaction time mean0.00.00.10.0-0.3-0.2
Reaction time mean AUC0.00.00.1-0.1-0.1-0.3
Median of all reaction times0.00.00.1-0.20.0-0.3
Reaction time omissions0.20.30.7-0.50.2-0.8
Reaction time false alarm rate0.60.91.1-1.00.9-0.9
Reaction time premature initiation rate0.20.20.40.6-0.30.4
Reaction time premature initiations0.10.10.20.5-0.1-0.1
Std. dev. reaction times0.20.30.60.5-0.80.1
Reaction time trials completed0.10.20.4-0.20.3-0.6
Reaction time trials AUC0.20.30.6-0.30.5-0.8
Run reversals in cocaine runway, females0.20.20.30.5-0.5-0.0
Run reversals in cocaine runway, males0.20.20.2-0.40.4-0.4
Latency to leave start box in cocaine runway0.00.00.10.2-0.10.0
Latency to leave start box in cocaine runway, F0.10.10.2-0.00.2-0.5
Latency to leave start box in cocaine runway, M0.00.00.00.0-0.10.2
Std. dev. time between licks in bursts0.91.11.90.9-0.81.4
Total sessions with >9 infusions1.71.92.1-1.41.2-1.4
Short access day 1 total inactive lever presses0.30.40.40.6-0.50.7
Short access day 10 total inactive lever presses2.42.63.51.5-1.51.9
Short access day 1 total infusions0.20.20.3-0.60.4-0.4
Short access day 10 total infusions0.60.60.8-0.90.7-0.7
Short access total infusions1.21.41.6-1.21.1-1.1
Short access day 1 locomotion0.90.91.6-0.70.8-1.3
Short access day 10 total locomotion1.01.11.31.2-0.91.1
Short access total locomotion0.80.81.0-0.71.0-1.0
One hour access (0.3 mA shock)1.01.11.31.0-1.11.0
Compulsive drug intake0.00.00.00.1-0.2-0.1
One hour access (shock baseline)0.00.10.10.1-0.20.3
Social response proportion3.43.74.22.0-1.81.9
Social responses1.31.62.81.7-1.10.9
Social time3.03.94.92.2-2.01.7
Soleus weight0.20.71.4-0.60.6-1.2
Bone: stiffness1.42.22.31.5-1.51.4
Tibialis anterior weight0.10.20.3-0.50.4-0.4
Time to tail flick, vehicle, before self-admin0.70.71.0-0.51.0-1.0
Time to tail flick, vehicle, after self-admin0.20.30.40.6-0.30.5
Time to tail flick, test, before self-admin1.41.41.9-1.40.7-1.3
Time to tail flick, test, after self-admin0.20.20.60.30.2-0.8
Delta time to tail flick, vehicle, before/after SA0.70.70.80.9-0.90.8
Delta time to tail flick, test, before/after SA0.10.10.20.40.3-0.3
Tibia length2.36.47.22.5-2.72.4
Ambulatory time before self-admin0.10.20.40.0-0.20.7
Ambulatory time after self-admin8.79.511.13.3-3.02.9
Bone: tissue strength3.02.93.41.6-1.91.6
Total heroin consumption0.81.01.30.9-0.81.1
Bone: trabecular number1.01.62.01.3-1.41.0
Bone: trabecular spacing0.40.50.90.6-0.60.9
Bone: trabecular thickness0.30.30.4-0.60.4-0.6
Bone: trabecular tissue density2.63.63.8-1.91.9-1.9
Water consumed over 24 hours0.20.30.40.6-0.60.3
Number of responses in last shaping day0.00.00.10.3-0.00.2