Hub : Genes

Ksr1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	RMTg	isoform ratio	XM_039085012.2	0.12	0.1	3.5e-03	0.13	0.06	0.11	0.1	2.2e-04	8.3e-03	8.1e-04	1.4e-03
2	OFC	mRNA stability	Ksr1	0.2	0.14	2.8e-03	0.12	0.07	0.11	0.1	7.0e-04	9.2e-03	1.3e-03	2.8e-03
3	pVTA	intron excision ratio	chr10_64475594_64479640	0.3	0.18	1.8e-03	0	0.04	0.03	0.02	2.7e-01	3.0e-04	9.7e-04	1.2e-02
4	pVTA	intron excision ratio	chr10_64477572_64479640	0.39	0.18	3.7e-05	-0	0.07	0.07	0.03	4.1e-01	1.3e-06	1.2e-06	1.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.3	2.3	5.4	1.2	2.3	1.5	-0.4
Area under the delay curve	0.2	0.2	0.4	-0.5	-0.6	0.3	-0.3
BMI with tail	1.1	3.9	9.2	3.0	1.6	-1.2	1.6
BMI without tail	1.0	3.1	6.5	2.5	1.4	-1.1	1.7
Body weight	1.4	6.2	12.9	3.2	3.6	1.3	-0.3
Weight adjusted by age	2.6	3.9	6.8	0.7	-1.1	-2.6	2.6
Bone surface	0.7	1.3	1.7	1.3	1.2	-0.3	1.3
Bone volume	0.6	1.0	2.2	1.2	1.5	0.3	0.8
Breakpoint value in progressive ratio session	3.1	3.8	6.5	-0.2	1.6	2.5	-2.4
Number of licking bursts	0.5	0.8	1.6	-1.3	-1.0	-0.8	0.0
Context. condit. distance diff. score	0.3	0.3	0.7	0.8	0.8	0.1	-0.0
Locomotion velocity, session 1	1.3	1.4	3.1	1.4	1.8	0.6	-0.3
Locomotion distance, session 1	0.2	0.2	0.5	-0.1	0.2	-0.5	0.7
Locomotion velocity, session 2	0.0	0.1	0.1	0.3	0.3	0.2	0.1
Locomotion distance, session 2	0.8	1.1	1.7	1.3	0.8	-0.6	1.2
Locomotion velocity, session 3	1.5	1.7	3.2	-1.8	-1.8	-0.5	-0.0
Locomotion distance, session 3	0.4	0.4	0.7	-0.6	-0.8	-0.7	0.5
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	-0.0	0.1	0.1	-0.1
Stereotopy head waving duration, day 3	0.5	0.5	1.2	-1.1	-0.5	0.6	-0.5
Locomotion velocity, session 7	0.7	0.8	2.1	0.5	-0.1	-0.9	1.4
Locomotion distance, session 7	0.6	0.7	1.7	0.6	0.0	-0.9	1.3
Stereotopy head waving bouts, day 7	0.7	0.8	1.2	0.9	1.1	1.0	-0.6
Stereotopy head waving duration, day 7	0.6	0.7	1.1	0.5	0.8	1.1	-0.8
Locomotion velocity, session 8	0.0	0.0	0.2	0.1	0.4	0.1	0.1
Locomotion distance, session 8	0.4	0.6	1.1	1.1	0.7	-0.6	0.8
Degree of sensitization distance	1.4	1.5	3.7	1.9	1.4	0.1	0.3
Degree of sensitization stereotypy	1.0	1.0	1.3	0.9	1.2	1.1	-0.9
Conditioned locomotion	1.8	2.1	3.5	-1.7	-1.9	-1.3	0.7
Cocaine response after cond. corrected	0.9	1.1	2.4	1.6	0.9	-0.6	0.8
Cocaine response after cond. not corrected	1.1	1.2	2.8	1.7	1.3	-0.2	0.7
Cocaine response before conditioning	0.1	0.2	0.4	0.2	0.6	0.5	-0.0
Saline control response	0.0	0.1	0.1	-0.2	-0.2	-0.1	0.4
Bone: connectivity density	1.3	2.1	5.4	1.5	2.3	0.7	0.4
Bone: cortical apparent density	0.4	0.5	1.4	-1.2	-0.6	0.3	-0.3
Bone: cortical area	1.4	2.2	3.5	-1.3	-1.9	-1.6	1.1
Bone: cortical porosity	0.9	1.0	1.9	0.5	-0.4	-1.2	1.4
Bone: cortical porosity	1.0	1.1	2.2	0.3	-0.5	-1.3	1.5
Bone: cortical thickness	1.7	2.7	5.2	-2.1	-2.3	-1.0	0.5
Bone: cortical thickness	0.7	0.9	1.3	-0.9	-0.7	-0.9	1.1
Bone: cortical tissue density	0.3	0.4	1.0	-1.0	-0.4	0.4	-0.3
Condit. Reinf. active minus inactive responses	0.4	0.5	1.2	-1.1	-0.8	-0.1	-0.2
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	-0.6	-0.7	-0.6	0.3
Condit. Reinf. active responses	0.0	0.0	0.0	-0.2	-0.2	-0.1	-0.0
Condit. Reinf. inactive responses	0.2	0.3	0.7	0.8	0.4	-0.3	0.2
Incentive salience index mean	0.2	0.2	0.4	-0.5	-0.7	-0.4	0.3
Condit. Reinf. lever presses	0.2	0.2	0.8	0.9	0.4	-0.1	0.2
Condit. Reinf. active minus inactive responses	0.7	0.9	2.5	-1.6	-0.5	0.7	-0.7
Condit. Reinf. active-inactive response ratio	1.5	1.7	2.6	-1.5	0.0	1.6	-1.4
Condit. Reinf. active responses	0.4	0.5	1.6	-1.2	-0.6	0.3	-0.1
Condit. Reinf. inactive responses	0.8	1.0	1.9	0.0	-0.7	-1.3	1.4
Condit. Reinf. lever presses	1.5	2.1	5.9	-2.4	-1.3	0.6	-0.7
Condit. Reinf. lever reinforcers received	0.6	0.8	2.5	-1.6	-0.8	0.2	0.0
Conditioned reinforcement - actives	0.1	0.2	0.3	0.6	0.5	-0.1	0.4
Conditioned reinforcement - inactives	0.5	0.7	1.6	0.5	-0.1	-0.9	1.3
Conditioned locomotion	0.6	0.8	1.2	1.0	0.2	-1.1	0.9
Patch foraging indifference point 0 sec	0.4	0.7	2.0	-1.4	-0.8	0.0	-0.2
Patch foraging indifference point AUC	1.2	1.7	4.3	-2.1	-1.5	-0.3	-0.3
Delay disc. indifference point, 0s delay	0.5	0.5	1.0	-0.9	-1.0	-0.5	0.4
Delay disc. indifference point, 16s delay	0.3	0.3	0.7	0.1	0.0	0.9	-0.8
Delay disc. indifference point, 2s delay	1.0	1.1	2.1	-1.5	-1.1	0.6	-0.8
Delay disc. indifference point, 24s delay	2.0	2.2	4.3	1.2	-0.1	-1.8	2.1
Delay disc. indifference point, 4s delay	1.2	1.3	2.3	-0.4	0.5	1.5	-1.5
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	-0.2	-0.1	0.7	-0.7
Indifference point function ln k	1.1	1.9	2.8	1.2	1.5	1.7	-1.1
Indifference point function log k	1.1	1.9	2.8	1.2	1.5	1.7	-1.1
Patch foraging total patch changes 0 sec	0.3	0.5	1.6	-1.3	-0.8	-0.0	-0.2
Patch foraging total patch changes 12 sec	0.4	0.5	1.6	-1.3	-0.5	-0.3	0.2
Patch foraging total patch changes 18 sec	1.2	1.8	5.1	-2.3	-1.2	0.2	-0.8
Patch foraging total patch changes 24 sec	1.2	2.1	6.1	-2.5	-1.3	0.4	-0.7
Patch foraging total patch changes 6 sec	2.1	3.3	7.5	-2.7	-2.2	-0.8	0.4
Patch foraging time to switch 0 sec	0.6	1.2	2.9	1.7	1.4	0.1	-0.1
Patch foraging water rate 0 sec	0.8	1.7	4.0	-2.0	-1.7	-0.4	-0.0
Patch foraging water rate 12 sec	0.0	0.1	0.1	0.3	0.4	0.1	0.2
Patch foraging water rate 18 sec	0.5	0.8	1.4	1.2	1.1	0.8	-0.3
Patch foraging water rate 24 sec	0.3	0.4	0.6	-0.8	-0.5	-0.4	0.8
Patch foraging water rate 6 sec	0.4	0.6	1.2	-1.1	-0.8	0.4	-0.6
Seeking ratio, delayed vs. immediate footshock	1.1	1.4	2.5	-1.5	-1.6	-0.9	0.2
Distance traveled before self-admin	0.9	1.2	2.8	-1.3	-1.7	0.1	-0.4
Distance traveled after self-admin	0.1	0.1	0.3	0.2	-0.2	-0.0	0.6
Extensor digitorum longus weight	0.7	2.6	4.6	2.1	0.8	-1.5	1.7
Bone: elastic displacement	1.3	1.5	3.4	-1.8	-1.6	-0.2	-0.0
Bone: elastic work	4.8	6.3	13.5	-3.7	-3.2	-1.0	0.5
Bone: endosteal estimation	0.1	0.3	0.5	0.1	-0.2	-0.7	0.7
Bone: endosteal perimeter	0.0	0.1	0.2	0.3	0.5	0.2	-0.2
Epididymis fat weight	4.7	16.0	30.2	5.5	5.5	2.0	-0.4
Delta time in closed arm before/after self-admin	1.2	1.1	1.9	-0.8	-0.9	1.0	-1.4
Delta time in open arm before/after self-admin	1.6	1.6	3.9	1.2	2.0	-0.4	0.9
Diff in mean of infusions in LGA sessions	1.7	2.1	3.2	0.2	1.5	1.7	-1.8
Delay discount exponential model param	0.1	0.1	0.2	0.4	0.4	-0.3	0.3
Extinction: sum of active levers before priming	0.4	0.4	1.1	0.5	1.0	0.6	-0.0
Active lever presses in extinction session 6	0.2	0.2	0.3	0.6	0.3	0.3	-0.5
Bone: final force	0.9	1.5	2.1	-0.8	-1.2	-1.4	1.4
Bone: final moment	0.7	1.2	1.6	-0.8	-1.1	-1.2	1.1
Food consumed during 24 hour testing period	0.1	0.2	0.3	-0.1	-0.5	0.2	-0.5
Glucose	0.7	1.0	2.3	-1.3	-1.5	-0.5	0.1
Heart weight	0.5	0.7	1.3	1.1	1.0	-0.3	0.8
Delay discount hyperbolic model param	0.3	0.3	0.5	0.7	0.7	-0.3	0.4
Intermittent access intake day 1-15 change	0.9	1.8	3.7	0.1	-1.0	-1.9	1.6
Intermittent access intake escalation	1.0	2.1	4.2	0.2	-0.9	-2.1	1.8
Intermittent access intake escalation 2	1.7	1.9	3.2	-0.3	-1.3	-1.8	1.6
Intermitt. access day 1 inactive lever presses	0.4	1.6	2.8	-0.3	-1.1	-1.7	1.4
Intermitt. access day 15 inactive lever presses	0.8	1.7	2.8	-1.7	-1.3	-1.2	0.9
Intermitt. access escalation Index	2.4	3.4	4.1	1.5	2.0	2.0	-1.8
Intermittent access day 1 total infusions	0.1	0.1	0.4	0.3	0.6	-0.1	0.0
Intermittent access day 15 total infusions	0.9	1.4	2.9	0.6	0.2	-1.7	1.5
Intermittent access terminal intake (last 3 days)	0.4	0.6	0.9	0.9	0.9	-0.6	0.6
Intermittent access total infusions	0.4	0.5	1.3	0.3	0.1	-1.2	0.8
Intermittent access day 1 locomotion	0.4	0.5	1.2	0.2	-0.1	-1.1	0.9
Intermittent access day 15 total locomotion	1.8	3.3	6.5	0.8	-0.6	-2.6	2.3
Intermittent access total locomotion	2.8	3.3	6.8	0.7	-0.5	-2.6	2.4
Intermittent access standard deviation	1.1	2.2	4.4	-0.4	-0.9	-2.1	1.9
Left kidney weight	0.1	0.5	0.8	0.3	0.9	0.9	-0.6
Right kidney weight	0.1	0.7	1.1	1.0	1.1	0.5	-0.6
Cocaine induced anxiety	1.1	1.5	2.7	-0.8	0.5	1.6	-1.6
Post-drug Anxiety	4.1	4.4	7.7	0.0	1.5	2.8	-2.7
Baseline Anxiety	0.2	0.2	0.3	0.3	0.5	0.6	-0.5
Tail length	0.2	0.9	2.1	0.8	1.4	1.0	-0.3
Length with tail	1.1	4.6	7.1	1.0	2.7	2.7	-1.8
Length without tail	1.0	3.1	4.2	1.0	2.1	2.0	-1.8
Times rat made contact with spout	0.1	0.1	0.2	0.3	-0.1	0.4	-0.3
Lifetime Intake	0.3	0.4	0.6	0.5	0.5	-0.8	0.7
Liver weight, left	3.9	6.4	12.0	2.8	3.5	2.0	-1.3
Liver weight, right	3.9	6.9	11.9	2.5	3.4	2.4	-1.9
Locomotor activity	0.3	0.5	0.7	-0.8	0.3	0.8	-0.8
Locomotor testing distance	0.2	0.3	0.6	-0.8	0.1	0.6	-0.5
Locomotor testing rearing	0.2	0.3	1.2	-1.1	-0.3	0.3	-0.2
Locomotion in novel chamber	0.8	1.0	2.8	-0.6	-1.7	-0.9	0.5
Locomotion in novel chamber post-restriction	0.7	1.1	1.8	0.8	0.7	1.3	-1.3
Fecal boli incidents, locomotor time 1	1.1	1.5	2.5	1.3	0.4	-1.3	1.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	-0.4	-0.1	-0.3	0.3
Time >=10cm from walls, locomotor time 1	1.7	1.8	3.3	-0.1	-0.8	-1.8	1.8
Bouts of movement, locomotor time 1	1.3	1.5	2.1	-0.6	-1.3	-1.4	1.3
Total resting periods, locomotor time 1	1.8	2.1	3.4	-0.5	-1.3	-1.9	1.7
Rest time, locomotor task time 1	1.7	2.1	4.0	-0.1	-0.9	-2.0	1.9
Distance moved, locomotor task time 1	1.2	1.7	3.2	-0.4	0.6	1.8	-1.8
Vertical activity count, locomotor time 1	1.0	2.5	4.3	-0.4	1.1	2.1	-2.1
Time >=10cm from walls, locomotor time 2	3.4	5.1	10.1	0.1	-0.7	-3.2	3.1
Bouts of movement, locomotor time 2	0.3	0.4	0.8	-0.9	-0.3	0.5	-0.7
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.5	-0.4	-0.0	-0.1
Rest time, locomotor task time 2	0.7	0.9	1.3	-0.6	-1.1	-1.1	0.9
Distance moved, locomotor task time 2	1.6	1.9	3.6	0.0	0.9	1.9	-1.8
Vertical activity count, locomotor time 2	2.8	3.9	6.9	-0.2	1.5	2.6	-2.6
Light reinforcement 1	0.4	1.1	1.9	-0.1	0.8	1.4	-1.3
Light reinforcement 2	1.5	2.2	5.4	-0.5	0.4	1.8	-2.3
Bone: marrow area	0.1	0.3	0.6	0.1	-0.3	-0.8	0.8
Bone: maximum diameter	0.6	1.2	1.9	-0.5	-1.1	-1.4	1.1
Bone: maximum force	1.5	2.7	4.0	-0.8	-1.6	-2.0	1.8
Bone: maximum moment	1.2	2.1	3.0	-0.8	-1.6	-1.7	1.5
Mean time between licks in bursts	0.4	0.9	1.6	1.3	0.3	-1.0	0.9
Mean num. licks in bursts	0.6	1.0	2.4	1.6	0.9	0.8	0.0
Cd content in liver	1.1	1.2	2.2	-1.5	-0.2	0.8	-1.4
Co content in liver	0.5	0.5	1.2	-1.1	-0.9	-0.5	-0.0
Cu content in liver	1.0	1.2	2.5	-1.6	-1.4	-0.3	-0.1
Fe content in liver	1.0	1.2	3.6	0.7	1.9	0.8	-0.0
K content in liver	0.2	0.2	0.2	0.4	0.4	0.3	-0.5
Mg content in liver	0.7	0.7	1.9	-1.4	-0.6	0.2	-0.8
Mn content in liver	0.2	0.3	0.5	-0.6	-0.7	-0.3	0.2
Na content in liver	1.0	1.0	2.1	0.3	1.3	1.4	-0.6
Rb content in liver	0.2	0.2	0.5	-0.3	-0.1	-0.6	0.7
Se content in liver	1.1	1.3	4.2	-2.1	-0.9	-0.5	0.0
Sr content in liver	0.2	0.2	0.6	0.8	0.3	0.0	0.4
Zn content in liver	0.3	0.3	0.6	-0.2	0.8	0.3	-0.6
Bone: minimum diameter	0.0	0.0	0.0	-0.1	-0.2	-0.1	-0.2
Time in familiar zone, hab. session 1	0.1	0.1	0.1	-0.4	-0.3	0.3	-0.2
Time in novel zone, hab. session 1	0.1	0.1	0.1	0.2	0.3	0.1	-0.2
Total zone transitions, hab. session 1	0.0	0.0	0.0	0.0	0.0	0.1	0.2
Total locomotion distance, hab. session 1	0.1	0.1	0.3	-0.3	-0.0	0.5	-0.3
Locomotion velocity, hab. session 1	0.1	0.2	0.5	-0.7	-0.5	0.0	0.2
Time in familiar zone, hab. session 2	0.7	0.7	1.1	-1.0	-0.0	1.0	-0.9
Time in novel zone, hab. session 2	0.1	0.2	0.3	0.1	-0.4	-0.6	0.3
Total zone transitions, hab. session 2	0.3	0.4	1.1	1.1	0.6	-0.0	0.5
Total locomotion distance, hab. session 2	0.1	0.1	0.3	-0.2	-0.4	-0.3	0.5
Locomotion velocity, hab. session 2	0.1	0.1	0.2	-0.2	-0.4	-0.2	0.4
Novel to familiar place preference ratio	0.5	0.6	1.2	1.1	0.4	-0.7	0.6
Novelty place preference	0.5	0.6	1.6	1.2	0.7	-0.4	0.3
Time in novel zone, NPP test	0.5	0.6	1.5	1.2	0.8	-0.3	0.2
Total zone transitions, NPP test	0.0	0.0	0.1	-0.1	0.2	-0.1	0.3
Total locomotion distance, NPP test	0.6	0.8	1.8	-1.3	-1.1	-0.4	0.3
Locomotion velocity, NPP test	0.7	1.0	1.9	-1.4	-1.2	-0.5	0.4
Intraocular pressure	1.7	2.4	3.7	-0.9	-1.9	-1.7	1.5
Delta distance traveled before/after self-admin	1.1	1.2	2.1	1.5	1.3	-0.4	0.9
Delta ambulatory time before/after self-admin	0.6	0.8	2.4	0.7	1.5	0.3	0.3
Parametrial fat weight	4.4	10.3	18.0	4.0	4.2	2.2	-1.4
Pavlov. Cond. lever latency	0.2	0.3	0.9	-0.3	-0.3	-0.5	0.9
Pavlov. Cond. magazine entry latency	0.5	0.7	1.3	0.2	0.7	1.0	-1.1
Pavlov. Cond. change in total contacts	0.5	0.6	1.4	-0.1	0.1	0.9	-1.2
Pavlov. Cond. index score	0.5	0.6	1.3	0.2	0.5	0.9	-1.2
Pavlov. Cond. latency score	0.5	0.6	1.4	0.4	0.6	0.8	-1.2
Pavlov. Cond. lever contacts	0.3	0.3	0.5	0.5	0.4	0.6	-0.7
Pavlov. Cond. magazine entry number	0.6	0.8	1.5	0.3	-0.3	-1.2	1.2
Pavlov. Cond. intertrial magazine entries	0.5	0.5	0.8	-0.6	-0.9	-0.9	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.2	0.0	0.3	0.8	-1.1
Pavlov. Cond. response bias	0.5	0.6	1.2	0.1	0.6	1.0	-1.1
Pavlov. Cond. lever latency	1.7	2.3	6.4	2.5	1.3	-0.7	0.8
Pavlov. Cond. magazine entry latency	0.5	0.7	1.1	-0.8	0.1	1.0	-1.1
Pavlov. Cond. change in total contacts	0.9	1.5	4.7	-2.2	-1.1	0.3	-0.2
Pavlov. Cond. index score	1.6	2.1	5.7	-2.4	-1.2	0.7	-0.9
Pavlov. Cond. latency score	1.8	2.4	6.5	-2.6	-1.3	0.6	-0.9
Pavlov. Cond. lever contacts	1.2	1.6	4.6	-2.2	-1.0	0.6	-0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	0.7	0.1	-0.1	0.0
Pavlov. Cond. intertrial magazine entries	0.5	0.7	1.7	0.8	0.3	-0.7	1.3
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.7	4.4	-2.1	-1.0	0.7	-0.9
Pavlov. Cond. response bias	1.2	1.6	3.8	-2.0	-0.6	1.0	-1.0
Time in closed arm before self-admin	0.8	1.1	2.7	1.1	1.6	0.6	0.1
Time in closed arm after self-admin	0.1	0.1	0.3	0.6	-0.2	0.3	-0.2
Time in open arm before self-admin	1.9	2.1	4.9	-1.2	-2.2	-1.4	0.5
Time in open arm after self-admin	0.7	0.8	1.6	0.1	0.1	-1.3	1.2
Bone: periosteal estimation	0.6	1.2	1.8	-0.7	-1.2	-1.3	1.0
Bone: periosteal perimeter	0.1	0.1	0.3	-0.2	-0.5	-0.5	0.3
Bone: post-yield work	0.5	0.8	2.5	1.6	0.3	-0.6	0.4
Progressive ratio test 1 active lever presses	0.4	0.4	0.9	-0.9	-0.2	0.4	-0.8
Progressive ratio test 1 breakpoint	0.4	0.5	1.1	-1.0	-0.3	0.5	-0.9
Progressive ratio test 1 inactive lever presses	1.2	1.8	2.6	-1.4	-1.6	-1.4	0.9
Progressive ratio test 2 active lever presses	0.7	0.8	1.3	-0.7	-1.1	-1.2	0.7
Progressive ratio test 2 breakpoint	0.7	0.8	1.3	-0.8	-1.0	-1.1	0.6
Progressive ratio test 2 inactive lever presses	1.0	1.7	3.2	-0.2	-1.1	-1.8	1.5
Incentive Sensitization - Responses	0.5	0.7	1.6	0.0	-0.6	-1.2	1.0
Incentive Sensitization - Breakpoint	0.5	0.7	1.5	0.0	-0.5	-1.2	1.0
Sum of active levers in priming session hrs 5-6	1.1	1.0	2.3	0.5	1.5	1.1	-0.6
Progressive ratio	1.6	2.5	4.6	-0.2	-1.3	-2.1	1.9
Food seeking constrained by brief footshock	0.0	0.0	0.1	0.1	0.2	-0.2	0.3
Seeking ratio, punishment vs. effort	0.9	1.4	2.6	0.3	0.9	1.6	-1.4
Retroperitoneal fat weight	1.5	6.3	9.5	1.3	2.8	3.1	-2.4
Reaction time number correct	1.6	3.1	5.9	1.3	-0.2	-2.2	2.4
Reaction time mean minus median	0.2	0.4	0.6	0.4	0.8	0.7	-0.7
Reaction time mean minus median AUC	0.5	1.4	2.8	1.5	1.7	0.6	-0.2
Reaction time num false alarms	2.6	3.7	8.5	-2.9	-2.2	0.4	-1.0
Reaction time num false alarms AUC	2.4	3.8	8.4	-2.9	-2.5	-0.0	-0.6
Reaction time trials correct on left	1.6	3.1	5.9	1.3	-0.2	-2.2	2.4
Reaction time trials on left	1.8	3.3	6.2	1.3	-0.2	-2.3	2.5
Reaction time mean	0.5	0.9	1.6	0.6	1.3	0.9	-0.9
Reaction time mean AUC	0.4	0.6	1.2	0.6	1.1	0.7	-0.7
Median of all reaction times	0.5	0.8	1.3	0.2	1.1	0.9	-0.9
Reaction time omissions	0.9	1.3	3.6	1.9	1.2	-0.1	0.1
Reaction time false alarm rate	3.0	4.1	9.0	-3.0	-2.0	1.0	-1.6
Reaction time premature initiation rate	1.5	2.0	3.4	0.4	1.5	1.8	-1.5
Reaction time premature initiations	0.3	0.5	1.1	0.8	1.1	0.6	-0.2
Std. dev. reaction times	0.3	0.5	1.3	1.1	0.8	-0.2	0.1
Reaction time trials completed	1.8	3.3	6.2	1.3	-0.2	-2.3	2.5
Reaction time trials AUC	1.7	3.3	6.4	1.1	-0.3	-2.3	2.5
Run reversals in cocaine runway, females	0.3	0.3	0.9	1.0	0.5	0.0	-0.4
Run reversals in cocaine runway, males	0.3	0.3	0.9	0.9	0.1	-0.4	0.5
Latency to leave start box in cocaine runway	0.6	0.6	1.1	-0.9	-0.7	0.4	-1.0
Latency to leave start box in cocaine runway, F	0.4	0.4	1.2	-0.5	-0.1	0.6	-1.1
Latency to leave start box in cocaine runway, M	0.2	0.1	0.4	-0.3	-0.7	-0.1	-0.3
Std. dev. time between licks in bursts	1.8	2.5	5.1	0.8	-0.9	-2.3	1.8
Total sessions with >9 infusions	0.4	0.5	1.0	0.9	1.0	0.2	0.2
Short access day 1 total inactive lever presses	2.5	3.3	5.2	2.3	1.3	-1.5	2.0
Short access day 10 total inactive lever presses	1.6	3.9	7.5	-0.1	-1.2	-2.6	2.7
Short access day 1 total infusions	0.7	0.9	1.8	0.3	0.4	-1.2	1.3
Short access day 10 total infusions	0.4	0.5	1.3	0.5	1.2	0.6	-0.4
Short access total infusions	0.1	0.2	0.3	0.2	0.6	-0.3	0.4
Short access day 1 locomotion	0.3	0.4	0.8	-0.4	-0.1	-0.9	0.7
Short access day 10 total locomotion	1.1	2.1	2.6	-1.5	-1.5	-1.6	1.3
Short access total locomotion	1.0	1.2	2.0	-0.8	-1.0	-1.4	1.0
One hour access (0.3 mA shock)	0.2	0.2	0.3	-0.5	-0.4	-0.6	0.4
Compulsive drug intake	0.5	0.6	1.4	0.9	1.2	0.4	-0.0
One hour access (shock baseline)	0.2	0.2	0.4	-0.5	-0.6	-0.6	0.1
Social response proportion	1.4	1.6	3.2	1.8	1.7	0.4	0.2
Social responses	1.1	1.4	2.4	1.3	0.8	-1.1	1.6
Social time	1.1	1.5	3.4	1.8	1.0	-0.8	1.0
Soleus weight	1.6	4.9	9.2	2.6	3.0	1.6	-1.1
Bone: stiffness	1.2	1.9	3.0	1.5	0.9	-1.2	1.7
Tibialis anterior weight	1.4	4.7	10.6	3.3	2.2	-0.7	1.6
Time to tail flick, vehicle, before self-admin	0.5	0.5	0.8	0.9	0.8	0.8	-0.0
Time to tail flick, vehicle, after self-admin	1.0	1.4	2.5	-0.9	0.4	1.6	-1.4
Time to tail flick, test, before self-admin	0.2	0.2	0.6	0.4	-0.2	-0.4	0.8
Time to tail flick, test, after self-admin	0.3	0.3	0.7	-0.6	-0.8	0.3	-0.4
Delta time to tail flick, vehicle, before/after SA	0.8	0.7	2.1	-1.4	-0.6	0.3	-0.6
Delta time to tail flick, test, before/after SA	0.5	0.5	1.3	-1.1	-0.7	-0.0	-0.4
Tibia length	0.0	0.0	0.1	0.2	-0.2	-0.3	0.0
Ambulatory time before self-admin	0.1	0.2	0.7	-0.2	-0.9	0.2	-0.1
Ambulatory time after self-admin	0.9	1.0	2.3	0.5	0.9	1.5	-0.8
Bone: tissue strength	0.6	0.6	0.9	-0.9	-0.6	0.6	-0.8
Total heroin consumption	1.3	1.6	3.2	1.3	1.8	1.0	-0.5
Bone: trabecular number	1.6	2.6	6.5	1.2	2.5	1.6	-0.3
Bone: trabecular spacing	1.0	1.3	2.9	0.4	-1.3	-1.7	0.7
Bone: trabecular thickness	0.4	0.5	0.9	-1.0	0.5	0.9	-0.2
Bone: trabecular tissue density	0.8	1.2	3.7	-1.9	-1.1	0.2	0.1
Water consumed over 24 hours	0.8	1.1	2.3	-0.3	0.5	1.4	-1.5
Number of responses in last shaping day	0.4	0.4	1.0	-1.0	-0.7	0.0	-0.2