Hub : Genes

Klf16

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Klf16 0.2 0.15 5.9e-03 0.1 0.08 0.1 0.09 2.1e-03 5.0e-03 2.5e-03 3.9e-03
2 pVTA intron excision ratio chr7_9139039_9146263 0.07 0.06 5.3e-03 0.01 0.02 0.02 0.01 1.1e-01 3.5e-02 4.9e-02 1.0e-01
3 pVTA intron excision ratio chr7_9144160_9146263 0.07 0.06 3.4e-03 0.01 0.03 0.01 0.01 7.7e-02 2.5e-02 7.6e-02 8.5e-02
4 BLA intron excision ratio chr7_9139039_9146263 0.12 0.07 1.2e-07 0.13 0.12 0.13 0.12 1.2e-07 4.1e-07 2.6e-07 3.6e-07
5 NAcc intron excision ratio chr7_9139039_9146263 0.06 0.04 1.9e-08 0.08 0.07 0.08 0.08 1.2e-09 1.4e-08 4.2e-09 3.9e-09
6 NAcc intron excision ratio chr7_9144160_9146263 0.08 0.05 8.6e-12 0.11 0.1 0.1 0.11 6.8e-13 2.0e-11 7.6e-12 3.0e-12
7 Brain gene expression Klf16 0.11 0.07 2.2e-11 0.1 0.1 0.09 0.11 6.0e-10 5.6e-10 8.6e-09 4.5e-10
8 pVTA gene expression Klf16 0.12 0.08 1.7e-05 0.12 0.1 0.1 0.1 9.1e-06 3.3e-05 5.4e-05 3.2e-05
9 PL gene expression Klf16 0.04 0.03 3.1e-05 0.04 0.05 0.04 0.04 2.0e-05 7.1e-06 9.5e-06 2.0e-05
10 BLA intron excision ratio chr7_9144160_9146263 0.11 0.07 1.8e-07 0.13 0.12 0.11 0.12 1.5e-07 5.3e-07 1.5e-06 3.8e-07
11 BLA gene expression Klf16 0.04 0.03 4.9e-03 0.03 0.01 0.01 0.01 1.5e-02 6.2e-02 5.2e-02 1.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.20.41.01.00.1-0.10.60.6-0.60.6-0.70.7-0.6-0.6
Area under the delay curve2.52.73.3-1.2-1.71.71.81.8-1.81.6-1.61.7-1.5-1.5
BMI with tail6.621.323.4-4.8-4.84.84.54.5-4.54.5-4.54.5-4.6-4.6
BMI without tail2.34.67.3-2.7-2.52.52.02.0-2.02.0-1.91.9-2.1-2.1
Body weight1.25.05.6-2.3-2.42.42.22.2-2.22.2-2.12.2-2.3-2.3
Weight adjusted by age0.20.31.1-1.0-0.80.80.20.2-0.20.3-0.30.3-0.4-0.4
Bone surface0.30.64.32.10.8-0.70.30.3-0.30.3-0.40.4-0.3-0.2
Bone volume0.30.64.42.10.8-0.70.30.3-0.30.3-0.40.5-0.3-0.3
Breakpoint value in progressive ratio session6.16.77.42.22.5-2.5-2.7-2.72.7-2.72.6-2.72.62.5
Number of licking bursts0.10.10.4-0.6-0.30.3-0.2-0.20.2-0.20.1-0.10.20.2
Context. condit. distance diff. score0.30.30.4-0.6-0.70.60.60.6-0.60.6-0.60.5-0.6-0.6
Locomotion velocity, session 10.40.41.51.20.9-0.9-0.4-0.40.4-0.40.5-0.40.50.5
Locomotion distance, session 10.10.20.90.90.6-0.60.20.2-0.20.2-0.20.2-0.2-0.1
Locomotion velocity, session 22.93.46.42.52.3-2.3-1.5-1.51.5-1.51.6-1.51.71.7
Locomotion distance, session 21.11.64.22.01.8-1.7-0.9-0.90.9-0.91.0-0.91.01.0
Locomotion velocity, session 36.47.48.22.52.7-2.7-2.7-2.72.7-2.72.8-2.82.92.9
Locomotion distance, session 30.00.00.0-0.1-0.10.1-0.0-0.00.0-0.0-0.0-0.10.00.0
Stereotopy head waving bouts, day 34.75.56.82.52.6-2.6-2.2-2.22.2-2.22.3-2.32.32.3
Stereotopy head waving duration, day 35.76.87.92.62.8-2.8-2.5-2.52.5-2.52.6-2.62.72.6
Locomotion velocity, session 70.60.71.21.10.7-0.7-0.8-0.80.8-0.80.9-0.70.70.7
Locomotion distance, session 70.10.10.4-0.6-0.50.50.10.1-0.10.1-0.10.1-0.2-0.2
Stereotopy head waving bouts, day 70.10.10.40.60.2-0.20.30.3-0.30.3-0.20.2-0.1-0.2
Stereotopy head waving duration, day 70.20.21.21.10.6-0.6-0.1-0.10.1-0.10.1-0.10.20.2
Locomotion velocity, session 80.30.41.91.41.0-0.9-0.3-0.30.3-0.30.4-0.30.40.4
Locomotion distance, session 80.10.10.30.60.5-0.5-0.2-0.20.2-0.20.2-0.20.20.2
Degree of sensitization distance0.40.40.5-0.6-0.70.70.60.6-0.60.6-0.60.7-0.7-0.7
Degree of sensitization stereotypy2.12.32.8-0.8-1.31.41.61.6-1.61.6-1.71.6-1.6-1.6
Conditioned locomotion1.21.43.8-2.0-1.51.51.01.0-1.01.1-0.91.0-1.0-1.0
Cocaine response after cond. corrected4.75.28.8-3.0-2.72.72.12.1-2.12.0-2.02.0-2.1-2.1
Cocaine response after cond. not corrected5.05.510.0-3.2-2.82.82.12.1-2.12.1-2.12.0-2.1-2.1
Cocaine response before conditioning0.40.50.70.80.8-0.8-0.7-0.70.7-0.60.7-0.70.70.7
Saline control response0.00.00.2-0.5-0.20.20.10.1-0.10.2-0.20.2-0.2-0.2
Bone: connectivity density0.40.71.10.3-0.40.41.01.0-1.01.0-1.01.0-0.9-0.9
Bone: cortical apparent density0.81.01.1-1.0-1.01.01.01.0-1.01.0-1.11.0-1.0-1.0
Bone: cortical area0.71.11.5-0.1-0.80.91.11.1-1.11.1-1.11.2-1.1-1.1
Bone: cortical porosity0.40.51.21.10.9-0.8-0.6-0.60.6-0.60.6-0.50.60.5
Bone: cortical porosity0.10.10.50.70.3-0.30.10.1-0.10.1-0.20.2-0.2-0.2
Bone: cortical thickness1.22.02.3-0.9-1.31.31.51.5-1.51.5-1.41.5-1.5-1.5
Bone: cortical thickness0.00.10.1-0.3-0.20.1-0.3-0.30.3-0.30.3-0.20.20.2
Bone: cortical tissue density0.50.70.8-0.9-0.80.80.80.8-0.80.8-0.90.8-0.8-0.8
Condit. Reinf. active minus inactive responses4.24.85.22.12.3-2.3-2.1-2.12.1-2.12.1-2.22.22.2
Condit. Reinf. active-inactive response ratio2.42.53.01.21.5-1.5-1.6-1.61.6-1.61.6-1.71.71.7
Condit. Reinf. active responses3.44.15.72.42.3-2.3-1.9-1.91.9-1.91.9-1.92.02.0
Condit. Reinf. inactive responses0.60.81.91.41.2-1.2-0.6-0.60.6-0.60.7-0.60.70.7
Incentive salience index mean2.02.43.61.91.8-1.8-1.4-1.41.4-1.41.4-1.51.51.5
Condit. Reinf. lever presses0.10.20.90.90.4-0.30.40.4-0.40.4-0.40.4-0.4-0.3
Condit. Reinf. active minus inactive responses2.63.23.81.31.6-1.6-1.9-1.91.9-1.91.9-1.91.91.9
Condit. Reinf. active-inactive response ratio0.30.30.4-0.30.2-0.2-0.6-0.60.6-0.70.6-0.60.60.6
Condit. Reinf. active responses2.33.23.51.71.6-1.7-1.8-1.81.8-1.91.8-1.81.81.8
Condit. Reinf. inactive responses1.11.32.21.51.1-1.1-1.1-1.11.1-1.11.1-1.11.11.1
Condit. Reinf. lever presses2.63.54.11.41.7-1.7-2.0-2.02.0-2.02.0-2.01.91.9
Condit. Reinf. lever reinforcers received1.82.52.91.41.4-1.4-1.7-1.71.7-1.71.6-1.61.71.7
Conditioned reinforcement - actives2.42.43.01.61.6-1.6-1.7-1.71.7-1.71.4-1.51.11.2
Conditioned reinforcement - inactives0.40.51.0-1.0-0.80.80.50.5-0.50.6-0.60.5-0.9-0.6
Conditioned locomotion7.79.210.53.03.1-3.1-3.1-3.13.1-3.22.9-3.02.82.9
Patch foraging indifference point 0 sec0.10.20.3-0.3-0.40.40.50.5-0.50.5-0.50.5-0.5-0.5
Patch foraging indifference point AUC1.01.11.40.81.0-1.0-1.1-1.11.1-1.21.0-1.11.01.0
Delay disc. indifference point, 0s delay7.98.710.4-1.9-2.52.63.13.1-3.13.2-3.23.2-3.2-3.1
Delay disc. indifference point, 16s delay0.20.20.3-0.3-0.40.40.60.6-0.60.4-0.40.3-0.3-0.3
Delay disc. indifference point, 2s delay6.16.87.6-2.0-2.52.52.72.7-2.72.8-2.82.8-2.6-2.5
Delay disc. indifference point, 24s delay0.80.81.0-0.9-1.00.91.01.0-1.00.7-0.70.8-0.7-0.9
Delay disc. indifference point, 4s delay1.31.42.0-0.6-1.11.11.41.4-1.41.2-1.21.2-1.0-1.0
Delay disc. indifference point, 8s delay1.21.21.7-1.2-1.31.31.11.1-1.11.0-1.01.1-1.1-0.9
Indifference point function ln k0.20.30.5-0.5-0.70.70.50.5-0.50.6-0.60.5-0.5-0.5
Indifference point function log k0.20.30.5-0.5-0.70.70.50.5-0.50.6-0.60.5-0.5-0.5
Patch foraging total patch changes 0 sec0.10.10.2-0.3-0.40.40.40.4-0.40.4-0.40.4-0.4-0.4
Patch foraging total patch changes 12 sec0.20.31.0-1.0-0.70.70.40.4-0.40.4-0.40.4-0.4-0.5
Patch foraging total patch changes 18 sec1.21.51.61.11.2-1.2-1.3-1.31.3-1.21.2-1.21.31.3
Patch foraging total patch changes 24 sec0.10.10.10.20.3-0.3-0.3-0.30.3-0.30.3-0.30.30.3
Patch foraging total patch changes 6 sec0.20.30.40.60.7-0.7-0.6-0.60.6-0.60.6-0.50.60.5
Patch foraging time to switch 0 sec1.62.53.4-0.8-1.11.11.81.8-1.81.8-1.61.7-1.7-1.7
Patch foraging water rate 0 sec0.10.20.4-0.5-0.30.2-0.6-0.60.6-0.60.3-0.50.50.5
Patch foraging water rate 12 sec0.71.13.5-1.9-1.51.50.80.8-0.80.8-0.80.8-0.7-0.8
Patch foraging water rate 18 sec0.50.71.0-0.9-0.20.1-1.0-1.01.0-1.00.8-0.90.90.9
Patch foraging water rate 24 sec0.30.42.9-1.7-1.00.9-0.1-0.10.1-0.1-0.1-0.10.10.1
Patch foraging water rate 6 sec0.60.81.2-0.10.3-0.4-1.1-1.11.1-1.11.0-1.01.01.0
Seeking ratio, delayed vs. immediate footshock4.45.16.82.62.4-2.4-2.2-2.22.2-2.22.1-2.12.22.1
Distance traveled before self-admin0.50.50.9-0.3-0.60.60.70.7-0.70.6-0.90.8-1.0-0.9
Distance traveled after self-admin0.60.71.41.20.9-0.9-0.8-0.80.8-0.90.7-0.70.60.6
Extensor digitorum longus weight4.517.821.6-4.6-4.64.64.14.1-4.14.0-4.04.0-4.1-4.1
Bone: elastic displacement0.20.30.40.70.5-0.5-0.5-0.50.5-0.50.5-0.40.50.5
Bone: elastic work0.30.30.4-0.0-0.50.50.60.6-0.60.6-0.60.7-0.6-0.6
Bone: endosteal estimation0.20.50.6-0.2-0.60.60.80.8-0.80.8-0.80.7-0.7-0.7
Bone: endosteal perimeter0.20.41.61.20.7-0.7-0.4-0.40.4-0.40.4-0.40.50.5
Epididymis fat weight0.30.61.00.20.7-0.7-0.8-0.80.8-0.80.8-0.91.01.0
Delta time in closed arm before/after self-admin0.60.63.2-1.8-1.11.00.30.3-0.30.3-0.40.3-0.4-0.4
Delta time in open arm before/after self-admin1.31.31.6-0.8-1.01.01.31.3-1.31.2-1.11.2-1.0-1.1
Diff in mean of infusions in LGA sessions1.92.12.41.21.5-1.5-1.4-1.41.4-1.41.4-1.51.51.5
Delay discount exponential model param2.32.43.01.21.6-1.6-1.7-1.71.7-1.51.5-1.61.41.4
Extinction: sum of active levers before priming1.61.62.30.61.0-1.1-1.5-1.51.5-1.41.2-1.31.21.1
Active lever presses in extinction session 63.02.93.71.91.8-1.8-1.8-1.81.8-1.81.6-1.61.61.4
Bone: final force1.52.32.9-0.7-1.41.51.61.6-1.61.6-1.61.7-1.6-1.6
Bone: final moment1.11.82.3-0.5-1.31.31.41.4-1.41.4-1.41.5-1.5-1.4
Food consumed during 24 hour testing period0.50.60.8-0.8-0.90.90.70.7-0.70.7-0.90.8-0.7-0.7
Glucose1.42.02.3-1.4-1.51.51.41.4-1.41.4-1.41.4-1.4-1.5
Heart weight0.40.60.70.20.5-0.6-0.8-0.80.8-0.80.8-0.90.80.8
Delay discount hyperbolic model param3.23.43.91.51.9-1.9-2.0-2.02.0-1.81.8-1.91.81.7
Intermittent access intake day 1-15 change7.27.18.02.52.6-2.6-2.8-2.82.8-2.82.7-2.72.62.5
Intermittent access intake escalation7.37.28.62.02.4-2.5-2.9-2.92.9-2.92.7-2.82.62.6
Intermittent access intake escalation 28.88.710.22.22.7-2.7-3.2-3.23.2-3.23.1-3.13.02.8
Intermitt. access day 1 inactive lever presses0.30.30.80.30.3-0.3-0.7-0.70.7-0.90.5-0.60.40.4
Intermitt. access day 15 inactive lever presses0.60.60.80.50.7-0.7-0.8-0.80.8-0.80.9-0.80.90.9
Intermitt. access escalation Index0.40.40.60.1-0.30.30.70.7-0.70.7-0.80.7-0.7-0.8
Intermittent access day 1 total infusions0.00.00.1-0.1-0.20.20.20.2-0.20.3-0.20.3-0.2-0.1
Intermittent access day 15 total infusions2.32.53.11.21.4-1.4-1.8-1.81.8-1.71.7-1.61.61.6
Intermittent access terminal intake (last 3 days)1.21.41.71.01.1-1.1-1.3-1.31.3-1.21.2-1.11.11.0
Intermittent access total infusions0.30.30.50.40.4-0.4-0.7-0.70.7-0.60.5-0.50.50.5
Intermittent access day 1 locomotion0.40.40.50.50.6-0.6-0.7-0.70.7-0.60.7-0.70.60.7
Intermittent access day 15 total locomotion3.84.14.61.82.0-2.0-2.1-2.12.1-2.22.0-2.11.91.9
Intermittent access total locomotion1.01.21.41.21.1-1.1-1.2-1.21.2-1.21.0-1.00.90.9
Intermittent access standard deviation3.33.54.31.51.7-1.7-2.1-2.12.1-2.11.9-1.91.81.8
Left kidney weight0.00.00.30.60.3-0.3-0.0-0.00.0-0.00.10.0-0.1-0.1
Right kidney weight1.43.94.52.12.0-2.0-2.0-2.02.0-2.02.0-1.91.91.8
Cocaine induced anxiety0.50.51.41.21.0-1.0-0.6-0.60.6-0.60.7-0.50.40.4
Post-drug Anxiety0.30.31.01.00.8-0.8-0.3-0.30.3-0.30.7-0.30.50.5
Baseline Anxiety0.20.20.4-0.10.2-0.2-0.3-0.30.3-0.30.6-0.50.60.6
Tail length3.29.810.52.83.0-3.0-3.2-3.23.2-3.23.2-3.23.13.1
Length with tail1.86.78.22.92.7-2.7-2.6-2.62.6-2.62.6-2.42.42.4
Length without tail0.10.10.80.90.5-0.4-0.0-0.00.0-0.00.00.0-0.00.0
Times rat made contact with spout0.10.20.6-0.8-0.60.60.30.3-0.30.3-0.30.2-0.3-0.3
Lifetime Intake0.10.10.20.30.3-0.3-0.5-0.50.5-0.30.3-0.30.20.3
Liver weight, left2.43.85.4-2.3-2.12.11.91.9-1.91.9-1.81.8-1.8-1.8
Liver weight, right1.83.03.2-1.6-1.71.71.71.7-1.71.8-1.71.7-1.8-1.8
Locomotor activity3.04.88.73.02.5-2.4-2.1-2.12.1-2.12.1-1.92.01.9
Locomotor testing distance1.93.25.02.21.9-1.9-1.8-1.81.8-1.71.7-1.61.71.6
Locomotor testing rearing0.10.10.2-0.00.0-0.1-0.3-0.30.3-0.30.4-0.30.30.3
Locomotion in novel chamber0.30.40.60.30.5-0.5-0.8-0.80.8-0.80.6-0.70.60.6
Locomotion in novel chamber post-restriction0.81.01.40.90.9-0.9-1.0-1.01.0-1.01.0-1.11.21.2
Fecal boli incidents, locomotor time 11.61.82.8-1.7-1.41.41.11.1-1.11.2-1.21.3-1.4-1.6
Change in fecal boli incidents, locomotor task0.20.21.11.00.4-0.4-0.4-0.40.4-0.30.3-0.20.10.2
Time >=10cm from walls, locomotor time 10.60.61.6-0.0-0.50.50.70.7-0.70.7-0.71.0-1.1-1.3
Bouts of movement, locomotor time 10.20.20.20.40.4-0.4-0.5-0.50.5-0.50.5-0.50.40.3
Total resting periods, locomotor time 10.20.20.30.50.5-0.5-0.5-0.50.5-0.50.5-0.50.40.4
Rest time, locomotor task time 10.20.20.50.70.6-0.5-0.5-0.50.5-0.40.3-0.40.40.3
Distance moved, locomotor task time 10.60.71.1-0.2-0.60.60.90.9-0.90.8-0.81.0-0.9-1.0
Vertical activity count, locomotor time 10.10.10.2-0.3-0.50.50.10.1-0.10.2-0.20.3-0.2-0.2
Time >=10cm from walls, locomotor time 21.21.31.7-1.1-1.31.31.01.0-1.00.9-1.01.1-1.2-1.3
Bouts of movement, locomotor time 20.30.41.01.00.9-0.8-0.3-0.30.3-0.40.3-0.40.60.6
Total resting periods, locomotor time 20.30.31.01.00.8-0.8-0.2-0.20.2-0.30.3-0.40.50.6
Rest time, locomotor task time 20.40.51.01.00.9-0.9-0.5-0.50.5-0.60.7-0.60.70.6
Distance moved, locomotor task time 20.60.71.3-1.1-1.01.00.80.8-0.80.8-0.80.8-0.8-0.8
Vertical activity count, locomotor time 20.50.61.4-1.2-1.01.00.50.5-0.50.6-0.70.6-0.7-0.7
Light reinforcement 15.710.512.63.33.5-3.5-3.1-3.13.1-3.13.2-3.23.23.1
Light reinforcement 22.02.63.31.71.8-1.8-1.5-1.51.5-1.51.6-1.61.61.6
Bone: marrow area0.20.50.7-0.2-0.60.70.80.8-0.80.8-0.80.8-0.7-0.7
Bone: maximum diameter0.61.03.31.81.2-1.2-0.8-0.80.8-0.80.8-0.70.80.8
Bone: maximum force1.42.42.8-0.8-1.51.51.61.6-1.61.6-1.51.7-1.6-1.6
Bone: maximum moment1.11.92.3-0.7-1.41.41.51.5-1.51.5-1.41.5-1.4-1.4
Mean time between licks in bursts4.56.36.92.12.5-2.5-2.6-2.62.6-2.62.6-2.62.62.6
Mean num. licks in bursts0.10.10.10.0-0.10.20.30.3-0.30.3-0.30.2-0.3-0.3
Cd content in liver0.20.20.3-0.3-0.50.50.50.5-0.50.5-0.50.6-0.5-0.5
Co content in liver0.60.70.80.70.8-0.8-0.9-0.90.9-0.90.8-0.90.90.9
Cu content in liver0.20.20.40.3-0.20.20.60.6-0.60.6-0.50.6-0.6-0.6
Fe content in liver0.10.10.1-0.20.1-0.1-0.3-0.30.3-0.30.2-0.30.30.3
K content in liver0.10.10.30.50.1-0.10.30.3-0.30.3-0.40.4-0.3-0.3
Mg content in liver0.10.10.30.60.1-0.10.40.4-0.40.4-0.40.4-0.4-0.4
Mn content in liver0.70.84.02.01.2-1.1-0.5-0.50.5-0.50.4-0.40.50.5
Na content in liver1.21.31.9-0.5-0.80.91.21.2-1.21.2-1.41.3-1.2-1.2
Rb content in liver0.60.71.00.0-0.50.50.90.9-0.90.9-1.01.0-0.9-0.9
Se content in liver0.10.20.20.50.5-0.5-0.4-0.40.4-0.40.2-0.40.40.4
Sr content in liver0.10.10.2-0.4-0.10.0-0.3-0.30.3-0.30.2-0.30.30.3
Zn content in liver2.32.63.40.61.2-1.3-1.8-1.81.8-1.81.6-1.81.81.8
Bone: minimum diameter0.00.10.20.4-0.10.10.30.3-0.30.3-0.30.3-0.3-0.2
Time in familiar zone, hab. session 12.52.42.91.11.4-1.4-1.6-1.61.6-1.61.7-1.61.71.7
Time in novel zone, hab. session 11.31.31.7-0.4-0.90.91.21.2-1.21.2-1.31.3-1.3-1.3
Total zone transitions, hab. session 10.71.02.51.61.4-1.3-0.7-0.70.7-0.70.7-0.70.80.8
Total locomotion distance, hab. session 10.71.03.82.01.5-1.4-0.6-0.60.6-0.60.7-0.50.70.7
Locomotion velocity, hab. session 11.11.64.02.01.7-1.7-1.0-1.01.0-1.01.1-0.91.01.0
Time in familiar zone, hab. session 26.97.18.22.02.5-2.5-2.8-2.82.8-2.82.8-2.92.82.8
Time in novel zone, hab. session 25.35.36.1-1.5-2.12.22.42.4-2.42.4-2.42.5-2.4-2.4
Total zone transitions, hab. session 20.40.50.70.30.00.00.80.8-0.80.8-0.80.9-0.7-0.7
Total locomotion distance, hab. session 20.70.91.91.41.4-1.3-0.7-0.70.7-0.70.8-0.70.80.8
Locomotion velocity, hab. session 20.60.92.21.51.4-1.4-0.6-0.60.6-0.60.7-0.60.70.7
Novel to familiar place preference ratio4.95.06.0-1.3-2.02.02.32.3-2.32.3-2.42.4-2.4-2.4
Novelty place preference3.03.13.8-0.9-1.51.51.91.9-1.91.9-1.91.9-1.9-1.9
Time in novel zone, NPP test3.43.54.2-1.1-1.61.72.02.0-2.02.0-2.02.0-2.0-2.0
Total zone transitions, NPP test0.10.10.10.20.3-0.30.30.3-0.30.3-0.20.3-0.3-0.2
Total locomotion distance, NPP test0.10.20.20.30.2-0.10.50.5-0.50.5-0.40.5-0.4-0.4
Locomotion velocity, NPP test0.10.10.30.60.5-0.40.20.2-0.20.2-0.10.2-0.1-0.1
Intraocular pressure0.20.20.5-0.7-0.10.1-0.5-0.50.5-0.50.5-0.60.50.5
Delta distance traveled before/after self-admin1.71.82.21.31.4-1.4-1.3-1.31.3-1.31.5-1.41.51.3
Delta ambulatory time before/after self-admin1.71.92.21.51.5-1.5-1.3-1.31.3-1.31.4-1.41.41.4
Parametrial fat weight0.50.91.10.80.8-0.8-1.1-1.11.1-1.01.0-0.90.90.8
Pavlov. Cond. lever latency0.10.10.2-0.4-0.10.1-0.4-0.40.4-0.40.3-0.40.30.3
Pavlov. Cond. magazine entry latency3.14.04.31.72.0-2.0-2.0-2.02.0-2.02.1-2.12.12.1
Pavlov. Cond. change in total contacts0.00.00.10.30.3-0.3-0.2-0.20.2-0.20.2-0.20.20.2
Pavlov. Cond. index score0.30.40.90.90.8-0.8-0.5-0.50.5-0.50.6-0.50.60.6
Pavlov. Cond. latency score0.30.41.11.10.8-0.8-0.4-0.40.4-0.40.5-0.40.50.5
Pavlov. Cond. lever contacts0.10.10.50.70.3-0.30.20.2-0.20.2-0.20.2-0.2-0.1
Pavlov. Cond. magazine entry number0.70.91.0-0.8-1.01.00.90.9-0.90.9-1.01.0-1.0-1.0
Pavlov. Cond. intertrial magazine entries0.20.30.4-0.10.2-0.3-0.6-0.60.6-0.60.5-0.60.60.6
Pavlov. Cond. lever-magazine prob. diff.0.70.81.41.21.1-1.1-0.8-0.80.8-0.80.9-0.80.90.9
Pavlov. Cond. response bias1.11.41.61.11.2-1.2-1.1-1.11.1-1.11.2-1.21.21.2
Pavlov. Cond. lever latency0.81.11.5-1.2-0.90.91.11.1-1.11.0-1.20.9-1.0-0.9
Pavlov. Cond. magazine entry latency0.40.50.91.00.7-0.7-0.7-0.70.7-0.70.8-0.70.60.6
Pavlov. Cond. change in total contacts0.81.11.31.10.9-0.9-1.1-1.11.1-1.11.1-1.01.11.1
Pavlov. Cond. index score0.91.11.41.21.0-1.0-1.1-1.11.1-1.11.2-1.01.01.0
Pavlov. Cond. latency score0.81.01.51.20.9-0.9-1.0-1.01.0-1.01.1-0.90.90.9
Pavlov. Cond. lever contacts0.81.11.40.90.9-0.9-1.1-1.11.1-1.11.2-1.01.01.0
Pavlov. Cond. magazine entry number0.70.91.6-1.3-0.90.90.90.9-0.91.0-1.00.9-0.9-0.9
Pavlov. Cond. intertrial magazine entries0.20.30.9-0.9-0.70.70.40.4-0.40.4-0.40.4-0.4-0.4
Pavlov. Cond. lever-magazine prob. diff.0.91.11.61.31.0-1.0-1.1-1.11.1-1.11.2-1.01.01.0
Pavlov. Cond. response bias1.92.63.11.51.4-1.4-1.7-1.71.7-1.71.8-1.61.61.6
Time in closed arm before self-admin1.01.11.5-0.3-0.70.71.21.2-1.21.2-1.21.2-1.2-1.1
Time in closed arm after self-admin0.00.00.0-0.20.1-0.1-0.1-0.10.1-0.00.1-0.20.20.2
Time in open arm before self-admin0.91.01.60.90.9-0.9-1.1-1.11.1-1.20.9-1.00.80.9
Time in open arm after self-admin0.70.80.9-0.8-1.01.00.90.9-0.90.7-0.90.9-0.9-0.8
Bone: periosteal estimation0.40.91.20.1-0.70.71.11.1-1.11.1-1.11.1-1.0-1.0
Bone: periosteal perimeter0.10.11.01.00.3-0.30.00.0-0.00.0-0.00.1-0.0-0.0
Bone: post-yield work0.50.71.0-0.8-1.01.00.80.8-0.80.8-0.80.8-0.8-0.8
Progressive ratio test 1 active lever presses0.10.10.2-0.5-0.30.30.10.1-0.10.2-0.20.1-0.1-0.1
Progressive ratio test 1 breakpoint0.10.10.3-0.6-0.50.40.20.2-0.20.3-0.30.2-0.2-0.2
Progressive ratio test 1 inactive lever presses0.00.00.00.10.1-0.1-0.1-0.10.1-0.10.0-0.1-0.00.0
Progressive ratio test 2 active lever presses0.20.30.50.20.3-0.3-0.7-0.70.7-0.70.5-0.60.30.4
Progressive ratio test 2 breakpoint0.30.30.50.50.4-0.4-0.7-0.70.7-0.70.5-0.50.30.4
Progressive ratio test 2 inactive lever presses0.10.10.10.30.2-0.2-0.3-0.30.3-0.20.2-0.1-0.00.0
Incentive Sensitization - Responses0.30.30.60.20.3-0.3-0.7-0.70.7-0.80.4-0.50.20.3
Incentive Sensitization - Breakpoint0.30.30.60.30.4-0.4-0.7-0.70.7-0.80.5-0.60.20.3
Sum of active levers in priming session hrs 5-60.00.00.00.10.0-0.0-0.1-0.10.1-0.1-0.00.0-0.1-0.1
Progressive ratio0.20.20.8-0.9-0.50.50.40.4-0.40.4-0.30.3-0.4-0.3
Food seeking constrained by brief footshock0.10.10.30.20.6-0.5-0.3-0.30.3-0.30.3-0.40.40.4
Seeking ratio, punishment vs. effort0.20.20.50.70.6-0.6-0.3-0.30.3-0.30.2-0.30.40.4
Retroperitoneal fat weight0.30.91.4-1.2-1.01.01.01.0-1.00.9-0.90.8-0.8-0.9
Reaction time number correct0.40.62.1-1.5-1.11.10.50.5-0.50.5-0.60.4-0.5-0.4
Reaction time mean minus median0.71.01.10.90.8-0.9-1.0-1.01.0-1.11.0-1.01.01.0
Reaction time mean minus median AUC0.00.10.30.60.0-0.00.20.2-0.20.2-0.20.3-0.2-0.2
Reaction time num false alarms0.10.10.3-0.4-0.50.50.10.1-0.10.0-0.10.1-0.1-0.1
Reaction time num false alarms AUC0.10.10.5-0.7-0.60.60.10.1-0.10.1-0.20.1-0.1-0.1
Reaction time trials correct on left0.40.62.1-1.5-1.11.10.50.5-0.50.5-0.60.4-0.5-0.4
Reaction time trials on left0.40.62.0-1.4-1.11.10.50.5-0.50.5-0.70.5-0.5-0.5
Reaction time mean0.00.00.10.3-0.10.10.20.2-0.20.2-0.10.3-0.2-0.2
Reaction time mean AUC0.10.10.10.3-0.10.10.30.3-0.30.3-0.20.3-0.3-0.3
Median of all reaction times0.30.50.6-0.1-0.50.50.80.8-0.80.7-0.60.8-0.7-0.7
Reaction time omissions0.20.30.50.70.7-0.7-0.5-0.50.5-0.60.4-0.50.40.4
Reaction time false alarm rate0.00.00.00.0-0.20.20.10.1-0.10.1-0.10.1-0.1-0.1
Reaction time premature initiation rate1.31.82.20.91.2-1.2-1.4-1.41.4-1.41.5-1.41.41.4
Reaction time premature initiations0.91.21.70.20.7-0.7-1.3-1.31.3-1.21.2-1.31.31.3
Std. dev. reaction times0.20.20.40.60.4-0.4-0.5-0.50.5-0.50.5-0.40.50.4
Reaction time trials completed0.40.62.0-1.4-1.11.10.50.5-0.50.5-0.70.5-0.5-0.5
Reaction time trials AUC0.40.52.2-1.5-1.11.00.40.4-0.40.4-0.60.4-0.4-0.4
Run reversals in cocaine runway, females0.30.30.70.80.6-0.6-0.5-0.50.5-0.50.5-0.50.50.6
Run reversals in cocaine runway, males1.31.21.61.21.3-1.3-1.0-1.01.0-1.01.0-1.11.21.2
Latency to leave start box in cocaine runway0.80.93.01.71.1-1.1-0.8-0.80.8-0.80.7-0.60.60.5
Latency to leave start box in cocaine runway, F0.20.20.91.00.2-0.10.20.2-0.20.2-0.50.6-0.6-0.6
Latency to leave start box in cocaine runway, M3.33.23.71.21.5-1.6-1.9-1.91.9-1.91.9-1.91.81.9
Std. dev. time between licks in bursts0.70.82.01.41.0-1.0-0.8-0.80.8-0.80.8-0.70.80.8
Total sessions with >9 infusions0.00.00.20.3-0.00.0-0.0-0.00.00.1-0.30.2-0.4-0.3
Short access day 1 total inactive lever presses0.10.10.10.10.3-0.3-0.3-0.30.3-0.20.1-0.20.10.2
Short access day 10 total inactive lever presses0.00.10.2-0.00.1-0.1-0.3-0.30.3-0.40.2-0.20.20.2
Short access day 1 total infusions0.10.10.40.60.5-0.5-0.3-0.30.3-0.10.2-0.20.00.1
Short access day 10 total infusions0.00.00.1-0.00.1-0.1-0.3-0.30.3-0.20.1-0.30.10.3
Short access total infusions0.00.00.10.10.0-0.0-0.1-0.10.10.0-0.10.1-0.2-0.1
Short access day 1 locomotion0.91.01.91.41.1-1.1-1.0-1.01.0-0.90.9-0.80.70.8
Short access day 10 total locomotion4.44.96.12.02.1-2.1-2.5-2.52.5-2.42.0-2.21.92.1
Short access total locomotion0.91.01.31.11.0-1.0-1.1-1.11.1-1.00.8-0.90.60.8
One hour access (0.3 mA shock)0.10.20.3-0.4-0.50.50.30.3-0.30.4-0.40.4-0.5-0.2
Compulsive drug intake1.41.41.9-0.7-1.01.11.21.2-1.21.2-1.31.3-1.4-1.2
One hour access (shock baseline)0.10.20.30.00.2-0.2-0.5-0.50.5-0.40.4-0.50.40.5
Social response proportion0.60.61.10.91.0-1.0-0.6-0.60.6-0.60.8-0.70.70.7
Social responses6.68.511.23.33.1-3.1-2.8-2.82.8-2.82.8-2.72.82.8
Social time0.60.81.2-1.1-0.80.80.90.9-0.90.9-0.80.9-0.9-0.9
Soleus weight9.427.429.7-5.1-5.45.45.25.2-5.25.2-5.25.2-5.2-5.2
Bone: stiffness3.35.25.5-1.7-2.32.32.32.3-2.32.3-2.32.3-2.3-2.3
Tibialis anterior weight1.24.24.6-1.7-2.12.12.12.1-2.12.0-2.12.0-2.1-2.1
Time to tail flick, vehicle, before self-admin0.40.41.11.10.8-0.8-0.4-0.40.4-0.50.4-0.40.50.5
Time to tail flick, vehicle, after self-admin0.20.30.6-0.40.1-0.2-0.5-0.50.5-0.40.6-0.60.80.7
Time to tail flick, test, before self-admin0.10.10.40.60.5-0.5-0.2-0.20.2-0.20.2-0.10.10.2
Time to tail flick, test, after self-admin0.20.20.50.40.6-0.5-0.3-0.30.3-0.30.3-0.40.60.7
Delta time to tail flick, vehicle, before/after SA0.30.31.8-1.3-0.80.80.30.3-0.30.4-0.20.2-0.2-0.2
Delta time to tail flick, test, before/after SA0.20.20.4-0.10.2-0.3-0.4-0.40.4-0.50.5-0.60.70.6
Tibia length1.02.83.31.51.6-1.6-1.7-1.71.7-1.71.8-1.61.71.7
Ambulatory time before self-admin0.40.40.7-0.3-0.60.60.60.6-0.60.5-0.80.7-0.9-0.8
Ambulatory time after self-admin0.30.40.91.00.7-0.7-0.6-0.60.6-0.70.5-0.50.40.4
Bone: tissue strength1.81.71.9-1.0-1.31.31.41.4-1.41.4-1.31.4-1.4-1.4
Total heroin consumption2.12.52.81.71.6-1.6-1.6-1.61.6-1.61.5-1.51.51.5
Bone: trabecular number0.40.72.41.61.1-1.1-0.6-0.60.6-0.60.5-0.50.60.6
Bone: trabecular spacing0.30.42.7-1.6-1.00.90.10.1-0.10.1-0.10.1-0.1-0.1
Bone: trabecular thickness0.50.62.41.50.3-0.20.70.7-0.70.7-0.70.9-0.7-0.8
Bone: trabecular tissue density1.52.13.6-1.9-1.61.61.41.4-1.41.4-1.31.3-1.4-1.4
Water consumed over 24 hours0.70.81.1-0.3-0.80.81.01.0-1.01.0-1.01.1-1.0-1.0
Number of responses in last shaping day0.20.20.40.50.3-0.4-0.6-0.60.6-0.40.3-0.30.10.2