Hub : Genes

Klc4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain isoform ratio XM_039083506.1 0.08 0.05 6.6e-06 0.03 0.05 0.05 0.02 4.9e-04 9.8e-06 1.6e-05 6.3e-03
2 Liver mRNA stability Klc4 0.02 0.02 9.2e-03 0.01 0.01 0.01 0.01 5.6e-02 1.3e-02 3.4e-02 3.7e-02
3 LHb gene expression Klc4 0.2 0.12 9.1e-04 0.08 0.08 0.1 0.09 6.8e-03 5.7e-03 1.9e-03 3.4e-03
4 Adipose gene expression Klc4 0.05 0.03 3.0e-05 0.02 0.03 0.03 0.03 5.3e-03 9.7e-05 3.6e-04 4.6e-04
5 BLA gene expression Klc4 0.14 0.08 8.6e-08 0.15 0.15 0.15 0.16 2.6e-08 3.0e-08 2.8e-08 8.4e-09
6 IL gene expression Klc4 0.29 0.15 3.2e-05 0.18 0.15 0.13 0.17 5.1e-05 1.7e-04 5.5e-04 6.1e-05
7 Brain mRNA stability Klc4 0.17 0.09 0.0e+00 0.19 0.17 0.18 0.2 7.1e-18 8.9e-16 6.7e-17 4.5e-18
8 Brain gene expression Klc4 0.79 0.09 0.0e+00 0.66 0.66 0.66 0.67 2.3e-81 9.7e-83 2.5e-82 6.4e-83
9 Liver intron excision ratio chr9_21840549_21840946 0.02 0.02 2.9e-03 0.01 0.01 0 0.01 1.2e-02 4.2e-02 3.5e-01 6.8e-02
10 PL gene expression Klc4 0.16 0.09 0.0e+00 0.2 0.19 0.19 0.2 3.8e-21 1.3e-20 4.7e-20 6.3e-21
11 IC gene expression Klc4 0.22 0.13 1.4e-07 0.14 0.12 0.13 0.13 2.3e-06 9.1e-06 5.5e-06 5.6e-06
12 BLA isoform ratio XM_006244516.5 0.09 0.06 9.8e-04 0.03 0.02 0.03 0.02 8.0e-03 2.3e-02 9.4e-03 3.0e-02
13 Liver gene expression Klc4 0.07 0.05 1.1e-04 0.04 0.03 0.03 0.04 2.9e-05 2.3e-04 1.3e-04 5.7e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.91.63.4-1.3-1.4-1.3-1.7-1.0-1.01.0-0.90.9-0.9-0.91.9-1.7
Area under the delay curve7.18.310.7-2.6-2.7-3.0-2.3-3.2-3.13.1-3.23.3-3.3-3.31.32.1
BMI with tail3.712.915.83.83.94.03.93.83.7-3.73.7-3.73.73.7-3.40.0
BMI without tail4.915.017.24.14.14.13.94.14.1-4.14.1-4.14.14.1-3.1-1.2
Body weight4.319.021.84.64.54.54.24.74.6-4.64.7-4.74.74.7-3.3-2.2
Weight adjusted by age0.30.40.70.60.70.60.60.70.8-0.70.7-0.60.60.7-0.0-0.6
Bone surface1.73.25.5-1.9-2.0-2.0-2.3-1.6-1.61.6-1.51.6-1.6-1.62.3-1.2
Bone volume1.01.73.1-1.4-1.5-1.5-1.7-1.1-1.11.1-1.11.1-1.1-1.11.8-1.2
Breakpoint value in progressive ratio session0.10.10.90.20.20.20.3-0.1-0.20.2-0.10.0-0.0-0.0-1.00.7
Number of licking bursts2.43.85.11.61.72.01.42.22.2-2.22.3-2.22.22.2-0.5-1.9
Context. condit. distance diff. score0.20.21.20.60.40.20.30.40.4-0.40.4-0.50.50.4-0.4-1.1
Locomotion velocity, session 10.91.02.61.11.11.01.30.70.7-0.70.7-0.70.70.7-1.61.2
Locomotion distance, session 12.22.83.61.91.81.71.71.71.7-1.71.7-1.71.71.7-1.7-0.6
Locomotion velocity, session 25.66.59.93.13.02.73.02.42.4-2.42.4-2.42.42.4-3.1-0.1
Locomotion distance, session 21.42.02.81.61.61.51.61.41.4-1.41.4-1.41.41.3-1.70.1
Locomotion velocity, session 30.81.02.51.21.11.01.30.70.6-0.70.6-0.70.70.7-1.61.2
Locomotion distance, session 30.80.92.4-0.6-0.7-0.8-0.5-1.0-1.01.0-1.01.0-1.0-1.0-0.01.6
Stereotopy head waving bouts, day 31.31.62.11.11.31.31.21.41.5-1.41.4-1.31.31.3-0.8-0.3
Stereotopy head waving duration, day 32.12.53.01.61.71.71.71.71.7-1.71.7-1.61.61.6-1.50.3
Locomotion velocity, session 70.60.62.30.90.80.71.00.30.3-0.30.3-0.40.40.4-1.51.5
Locomotion distance, session 70.30.42.00.60.50.50.70.20.2-0.20.2-0.30.30.2-1.11.4
Stereotopy head waving bouts, day 70.10.20.80.20.20.20.10.40.5-0.40.4-0.30.30.30.0-0.9
Stereotopy head waving duration, day 70.10.21.0-0.3-0.3-0.3-0.5-0.1-0.00.0-0.10.2-0.2-0.20.6-1.0
Locomotion velocity, session 80.50.61.31.10.90.70.90.60.6-0.60.6-0.70.70.6-1.1-0.3
Locomotion distance, session 81.01.52.11.41.31.21.21.21.2-1.21.2-1.31.31.2-1.3-0.7
Degree of sensitization distance2.02.02.51.51.51.61.61.41.4-1.41.4-1.51.51.5-1.5-0.0
Degree of sensitization stereotypy0.50.50.8-0.7-0.8-0.8-0.9-0.6-0.60.6-0.70.8-0.8-0.70.7-0.7
Conditioned locomotion1.82.15.5-1.1-1.2-1.2-0.8-1.6-1.61.6-1.61.5-1.5-1.50.02.3
Cocaine response after cond. corrected0.10.20.3-0.6-0.5-0.4-0.5-0.4-0.40.4-0.30.4-0.4-0.40.60.3
Cocaine response after cond. not corrected0.30.40.5-0.7-0.6-0.5-0.6-0.6-0.60.6-0.60.6-0.6-0.60.50.6
Cocaine response before conditioning0.10.10.60.30.30.30.40.0-0.0-0.0-0.0-0.10.10.1-0.70.8
Saline control response0.00.00.20.30.2-0.00.2-0.00.00.0-0.10.1-0.1-0.1-0.50.1
Bone: connectivity density1.62.56.4-1.9-1.8-1.6-2.2-1.2-1.21.2-1.11.1-1.1-1.12.5-1.8
Bone: cortical apparent density0.40.50.9-0.5-0.6-0.7-0.5-0.9-1.01.0-0.90.8-0.8-0.80.20.5
Bone: cortical area0.81.23.61.61.31.01.40.80.8-0.80.8-0.70.70.7-1.90.4
Bone: cortical porosity0.10.10.20.10.20.20.10.40.4-0.40.4-0.30.30.40.20.0
Bone: cortical porosity0.10.20.30.30.30.30.40.40.4-0.40.4-0.30.30.4-0.20.6
Bone: cortical thickness0.81.44.11.81.41.01.50.80.8-0.80.8-0.80.80.8-2.00.5
Bone: cortical thickness0.10.10.2-0.2-0.3-0.3-0.4-0.3-0.30.2-0.20.1-0.1-0.10.3-0.4
Bone: cortical tissue density0.40.61.0-0.6-0.7-0.8-0.6-1.0-1.01.0-0.90.8-0.8-0.80.20.5
Condit. Reinf. active minus inactive responses1.51.72.11.31.41.41.31.41.4-1.41.4-1.41.41.4-1.0-0.3
Condit. Reinf. active-inactive response ratio0.30.30.40.30.40.50.30.60.6-0.60.6-0.60.60.60.1-0.6
Condit. Reinf. active responses2.73.43.92.01.91.91.81.91.9-1.91.9-2.02.02.0-1.5-0.8
Condit. Reinf. inactive responses2.22.73.21.71.71.71.61.71.7-1.71.8-1.81.81.8-1.2-0.8
Incentive salience index mean2.32.83.92.01.91.81.91.61.7-1.61.6-1.71.71.7-1.8-0.2
Condit. Reinf. lever presses3.95.57.62.72.62.52.62.32.3-2.32.3-2.32.32.3-2.5-0.6
Condit. Reinf. active minus inactive responses0.10.11.1-0.1-0.1-0.2-0.30.20.2-0.20.2-0.10.10.10.6-1.0
Condit. Reinf. active-inactive response ratio0.60.72.20.40.50.60.30.91.0-1.00.9-0.90.90.90.3-1.5
Condit. Reinf. active responses0.00.00.3-0.1-0.0-0.2-0.10.10.2-0.10.00.0-0.0-0.00.2-0.6
Condit. Reinf. inactive responses0.10.10.30.10.1-0.10.2-0.2-0.20.2-0.20.3-0.3-0.3-0.50.6
Condit. Reinf. lever presses0.50.72.20.60.70.50.51.01.1-1.00.9-0.80.80.80.0-1.5
Condit. Reinf. lever reinforcers received0.00.10.4-0.1-0.1-0.3-0.2-0.00.10.0-0.10.1-0.1-0.10.3-0.6
Conditioned reinforcement - actives0.30.52.00.1-0.0-0.20.3-0.6-0.60.6-0.70.7-0.7-0.7-1.31.4
Conditioned reinforcement - inactives0.40.61.30.90.90.91.00.70.7-0.70.6-0.70.70.7-1.10.3
Conditioned locomotion0.20.20.40.40.50.60.50.60.6-0.60.6-0.50.50.5-0.3-0.1
Patch foraging indifference point 0 sec0.61.21.61.11.11.21.11.11.3-1.21.2-1.11.11.1-0.8-0.4
Patch foraging indifference point AUC1.11.65.01.51.41.31.70.80.8-0.80.7-0.80.80.7-2.21.5
Delay disc. indifference point, 0s delay1.92.13.4-1.7-1.4-1.2-1.2-1.5-1.51.5-1.51.5-1.5-1.50.61.8
Delay disc. indifference point, 16s delay9.810.813.6-3.1-3.2-3.5-2.9-3.7-3.63.7-3.73.7-3.7-3.71.81.7
Delay disc. indifference point, 2s delay3.23.54.5-1.8-1.7-1.7-1.4-2.1-2.12.1-2.12.1-2.1-2.10.71.8
Delay disc. indifference point, 24s delay1.21.41.9-1.1-1.2-1.4-1.2-1.2-1.31.3-1.21.2-1.2-1.21.1-0.2
Delay disc. indifference point, 4s delay2.72.85.5-1.1-1.2-1.4-0.7-1.9-1.81.8-1.92.0-2.0-2.0-0.32.3
Delay disc. indifference point, 8s delay4.04.76.4-1.9-2.0-2.3-1.7-2.5-2.42.4-2.52.5-2.5-2.50.81.8
Indifference point function ln k0.40.71.3-1.2-1.0-0.7-0.9-0.8-0.80.8-0.70.7-0.7-0.71.10.5
Indifference point function log k0.40.71.3-1.2-1.0-0.7-0.9-0.8-0.80.8-0.70.7-0.7-0.71.10.5
Patch foraging total patch changes 0 sec0.81.52.01.21.31.41.31.31.4-1.41.3-1.31.31.3-0.9-0.4
Patch foraging total patch changes 12 sec1.31.75.11.81.61.21.81.01.1-1.01.0-0.90.90.9-2.30.6
Patch foraging total patch changes 18 sec1.42.24.71.81.71.61.91.21.3-1.21.2-1.21.21.2-2.21.0
Patch foraging total patch changes 24 sec0.71.22.41.31.31.21.40.91.0-1.00.9-1.01.00.9-1.60.4
Patch foraging total patch changes 6 sec2.33.55.02.22.11.92.11.82.0-1.91.8-1.81.81.8-2.0-0.5
Patch foraging time to switch 0 sec3.77.511.1-2.9-3.0-3.3-3.2-2.7-2.72.7-2.62.6-2.6-2.63.1-1.0
Patch foraging water rate 0 sec2.86.014.62.72.82.83.21.91.9-1.91.8-1.91.91.9-3.82.3
Patch foraging water rate 12 sec4.08.410.83.13.23.33.22.92.9-2.92.9-2.92.92.9-2.90.3
Patch foraging water rate 18 sec1.21.82.51.51.51.51.61.31.4-1.31.3-1.31.31.3-1.40.3
Patch foraging water rate 24 sec1.92.73.81.71.82.01.91.71.7-1.71.6-1.51.51.6-1.60.6
Patch foraging water rate 6 sec0.60.93.10.90.91.11.20.50.4-0.50.4-0.50.50.6-1.51.7
Seeking ratio, delayed vs. immediate footshock1.92.33.0-1.7-1.7-1.6-1.7-1.6-1.41.4-1.51.5-1.5-1.51.6-0.1
Distance traveled before self-admin0.10.10.30.40.40.40.40.30.2-0.20.3-0.30.30.3-0.60.4
Distance traveled after self-admin2.12.53.01.61.71.71.71.71.7-1.71.7-1.61.61.6-1.50.6
Extensor digitorum longus weight0.10.50.90.80.70.90.80.50.6-0.50.6-0.90.90.8-0.80.3
Bone: elastic displacement0.60.60.9-0.6-0.7-1.0-0.7-0.9-1.00.9-0.90.9-0.9-0.90.40.2
Bone: elastic work0.10.11.10.30.0-0.3-0.2-0.1-0.10.1-0.10.1-0.1-0.10.0-1.0
Bone: endosteal estimation0.40.81.3-1.1-1.1-0.9-1.1-0.8-0.80.8-0.80.9-0.9-0.91.1-0.2
Bone: endosteal perimeter0.00.00.10.20.20.10.10.30.3-0.30.2-0.10.10.1-0.2-0.3
Epididymis fat weight2.79.111.12.92.93.02.53.33.3-3.33.3-3.33.33.3-1.6-2.7
Delta time in closed arm before/after self-admin0.70.63.4-0.6-0.6-0.5-0.90.10.1-0.10.0-0.10.10.01.7-1.8
Delta time in open arm before/after self-admin0.40.43.4-0.2-0.10.00.2-0.3-0.20.2-0.30.4-0.4-0.4-0.61.8
Diff in mean of infusions in LGA sessions0.91.12.51.11.11.31.30.90.9-0.90.9-1.01.01.0-1.60.2
Delay discount exponential model param7.18.010.42.52.62.92.33.23.1-3.13.2-3.23.23.2-1.3-1.9
Extinction: sum of active levers before priming0.20.21.10.20.30.40.50.10.1-0.10.0-0.00.00.0-1.10.9
Active lever presses in extinction session 60.40.41.80.60.70.70.90.40.3-0.30.3-0.30.30.3-1.31.1
Bone: final force0.40.71.41.20.90.70.80.80.8-0.80.8-0.70.70.7-0.9-0.8
Bone: final moment0.40.71.61.31.00.81.00.70.7-0.70.7-0.60.60.6-1.2-0.3
Food consumed during 24 hour testing period0.60.81.40.91.01.01.20.70.7-0.70.7-0.70.70.7-1.11.0
Glucose6.510.312.03.33.33.43.23.43.3-3.43.4-3.53.53.4-2.6-1.2
Heart weight0.20.31.20.80.70.40.70.40.5-0.50.4-0.30.30.3-1.1-0.2
Delay discount hyperbolic model param6.47.19.42.42.52.82.13.02.9-2.93.0-3.13.13.1-1.1-1.9
Intermittent access intake day 1-15 change0.00.00.20.30.30.10.30.10.0-0.10.10.0-0.0-0.0-0.4-0.1
Intermittent access intake escalation0.00.00.10.20.1-0.00.10.0-0.0-0.0-0.00.1-0.1-0.1-0.2-0.3
Intermittent access intake escalation 20.10.10.30.1-0.0-0.20.1-0.3-0.30.2-0.30.4-0.4-0.4-0.50.3
Intermitt. access day 1 inactive lever presses0.31.12.60.60.70.80.41.11.1-1.11.2-1.21.21.20.3-1.6
Intermitt. access day 15 inactive lever presses0.30.71.20.60.71.00.60.80.9-0.80.9-1.11.11.1-0.2-0.5
Intermitt. access escalation Index0.00.00.1-0.3-0.2-0.0-0.2-0.0-0.1-0.0-0.0-0.00.00.00.40.3
Intermittent access day 1 total infusions0.60.91.20.80.91.10.81.11.1-1.11.1-1.11.11.1-0.6-0.5
Intermittent access day 15 total infusions0.40.60.80.70.70.90.60.90.9-0.90.9-0.80.80.8-0.4-0.6
Intermittent access terminal intake (last 3 days)0.00.00.10.20.10.30.10.30.3-0.30.3-0.20.20.2-0.2-0.2
Intermittent access total infusions0.20.30.40.50.50.70.50.60.6-0.60.6-0.60.60.6-0.4-0.2
Intermittent access day 1 locomotion0.91.11.60.80.91.20.81.31.2-1.31.3-1.21.21.2-0.4-0.3
Intermittent access day 15 total locomotion0.71.31.71.21.21.21.11.31.3-1.31.2-1.11.11.1-0.9-0.1
Intermittent access total locomotion0.70.81.30.70.70.90.61.11.1-1.11.1-1.01.01.0-0.2-0.5
Intermittent access standard deviation1.32.73.8-1.7-1.8-1.9-2.0-1.6-1.61.6-1.61.6-1.6-1.61.8-0.5
Left kidney weight1.67.39.33.13.02.93.02.72.7-2.72.7-2.72.72.7-2.7-0.4
Right kidney weight1.67.410.83.23.13.03.32.72.6-2.62.5-2.52.52.5-3.30.5
Cocaine induced anxiety0.20.21.6-0.2-0.1-0.1-0.30.30.3-0.30.4-0.20.20.20.9-1.3
Post-drug Anxiety0.20.21.6-0.1-0.1-0.2-0.30.10.1-0.10.1-0.10.10.10.6-1.3
Baseline Anxiety0.40.40.8-0.3-0.4-0.5-0.3-0.8-0.80.8-0.80.6-0.6-0.6-0.30.9
Tail length1.24.85.72.22.12.01.82.32.3-2.42.4-2.42.42.3-1.2-2.4
Length with tail1.04.210.81.81.71.61.12.22.2-2.22.2-2.22.22.2-0.4-3.3
Length without tail0.62.04.01.41.21.20.91.51.5-1.51.5-1.51.51.5-0.6-2.0
Times rat made contact with spout4.04.65.72.02.22.31.92.32.3-2.32.4-2.42.42.4-1.2-1.6
Lifetime Intake0.00.00.0-0.1-0.10.1-0.10.00.0-0.00.00.0-0.0-0.00.00.0
Liver weight, left0.50.83.01.21.00.81.20.40.4-0.40.4-0.50.50.5-1.71.2
Liver weight, right2.54.46.52.52.32.32.22.12.0-2.12.1-2.12.12.1-2.1-1.1
Locomotor activity2.03.13.82.01.81.51.61.81.9-1.81.9-1.91.91.9-1.2-1.6
Locomotor testing distance1.83.34.21.91.81.51.41.91.9-1.92.0-2.02.02.0-1.1-1.9
Locomotor testing rearing2.44.86.52.52.52.32.52.12.2-2.22.1-2.12.12.2-2.50.1
Locomotion in novel chamber0.70.91.3-0.8-0.9-0.9-0.8-1.1-1.01.0-1.11.1-1.1-1.10.20.8
Locomotion in novel chamber post-restriction0.50.84.3-0.4-0.4-0.3-0.0-0.9-0.90.9-0.90.8-0.8-0.8-0.62.1
Fecal boli incidents, locomotor time 10.40.62.60.1-0.0-0.10.2-0.7-0.60.6-0.70.7-0.7-0.7-1.31.6
Change in fecal boli incidents, locomotor task0.10.10.1-0.3-0.2-0.1-0.0-0.3-0.30.3-0.30.3-0.3-0.3-0.00.3
Time >=10cm from walls, locomotor time 10.40.51.00.60.70.90.80.60.7-0.70.6-0.60.60.5-1.00.3
Bouts of movement, locomotor time 10.20.21.5-0.8-0.6-0.3-0.7-0.10.0-0.00.00.0-0.0-0.01.20.0
Total resting periods, locomotor time 10.20.20.5-0.2-0.00.3-0.20.50.6-0.60.5-0.50.50.50.7-0.2
Rest time, locomotor task time 10.50.71.1-1.0-0.9-0.8-0.8-0.9-0.80.8-0.80.9-0.9-0.90.50.5
Distance moved, locomotor task time 10.00.10.10.20.20.00.10.20.3-0.30.2-0.20.20.20.4-0.4
Vertical activity count, locomotor time 10.20.60.9-0.5-0.7-0.9-0.6-0.9-0.90.9-0.90.9-0.9-0.90.30.0
Time >=10cm from walls, locomotor time 20.60.81.30.91.01.11.10.70.9-0.90.8-0.80.80.8-1.10.8
Bouts of movement, locomotor time 20.20.41.40.40.40.40.40.60.7-0.70.6-0.60.60.50.0-1.2
Total resting periods, locomotor time 20.10.21.7-0.10.00.0-0.10.20.4-0.40.3-0.20.20.20.4-1.3
Rest time, locomotor task time 20.60.71.3-1.1-1.0-0.8-1.1-0.7-0.70.7-0.70.8-0.8-0.71.0-0.4
Distance moved, locomotor task time 21.01.21.51.01.11.11.11.21.2-1.21.2-1.21.21.2-0.40.4
Vertical activity count, locomotor time 20.10.10.3-0.1-0.2-0.2-0.0-0.4-0.40.4-0.40.4-0.4-0.4-0.20.5
Light reinforcement 11.53.65.12.22.12.02.21.91.9-1.91.8-1.81.81.8-2.30.1
Light reinforcement 21.93.03.91.61.61.71.32.02.0-1.91.9-1.91.91.8-0.7-1.6
Bone: marrow area0.40.91.2-1.1-1.1-0.9-1.1-0.8-0.80.8-0.90.9-0.9-1.01.1-0.2
Bone: maximum diameter0.40.72.11.11.00.81.10.60.6-0.60.6-0.50.50.5-1.40.7
Bone: maximum force0.10.11.30.30.1-0.1-0.10.20.2-0.20.1-0.10.10.00.1-1.1
Bone: maximum moment0.00.00.40.30.10.00.00.10.1-0.10.00.0-0.0-0.0-0.1-0.6
Mean time between licks in bursts1.33.15.7-2.2-2.1-1.8-2.2-1.6-1.61.6-1.61.6-1.6-1.62.4-0.3
Mean num. licks in bursts0.40.61.0-0.6-0.6-0.7-0.4-0.9-0.90.9-0.90.9-0.9-0.90.01.0
Cd content in liver1.51.72.3-1.5-1.4-1.3-1.3-1.2-1.31.2-1.21.3-1.3-1.31.21.2
Co content in liver0.10.10.4-0.6-0.4-0.3-0.5-0.3-0.30.3-0.20.2-0.2-0.20.7-0.0
Cu content in liver0.20.21.3-0.2-0.2-0.20.0-0.5-0.50.5-0.50.5-0.5-0.5-0.31.1
Fe content in liver0.10.10.30.50.40.30.40.30.3-0.30.3-0.30.30.3-0.5-0.3
K content in liver0.80.73.8-0.7-0.7-0.7-1.1-0.3-0.20.3-0.20.2-0.2-0.21.6-2.0
Mg content in liver0.20.20.5-0.3-0.5-0.6-0.6-0.5-0.50.5-0.50.5-0.5-0.50.3-0.7
Mn content in liver0.20.20.4-0.00.30.50.20.60.6-0.60.6-0.50.50.60.5-0.3
Na content in liver0.70.71.61.31.00.81.00.70.7-0.70.7-0.70.70.7-1.1-0.7
Rb content in liver3.33.85.1-1.7-2.0-2.1-1.8-2.3-2.22.2-2.22.2-2.2-2.21.00.7
Se content in liver1.01.21.61.01.21.21.31.11.1-1.11.1-1.21.21.1-1.00.8
Sr content in liver1.00.91.21.01.11.11.10.90.9-0.90.9-0.90.90.9-0.90.0
Zn content in liver1.31.41.9-0.9-1.0-1.2-0.8-1.4-1.41.4-1.41.4-1.4-1.30.21.2
Bone: minimum diameter0.30.60.90.90.80.70.80.80.8-0.80.7-0.60.60.6-0.9-0.1
Time in familiar zone, hab. session 11.11.13.11.21.21.11.30.80.8-0.80.8-0.80.80.8-1.81.0
Time in novel zone, hab. session 11.11.12.2-1.5-1.2-1.0-1.3-0.9-1.00.9-0.90.9-0.9-0.91.4-0.1
Total zone transitions, hab. session 14.15.76.62.62.52.52.42.52.5-2.52.5-2.52.52.5-2.3-0.8
Total locomotion distance, hab. session 14.56.48.12.82.82.72.82.52.5-2.52.5-2.52.52.5-2.7-0.1
Locomotion velocity, hab. session 14.15.87.62.82.72.52.72.42.4-2.42.4-2.42.42.4-2.6-0.1
Time in familiar zone, hab. session 22.12.23.4-1.5-1.6-1.8-1.7-1.5-1.51.5-1.41.5-1.5-1.51.4-0.6
Time in novel zone, hab. session 20.50.50.90.50.70.90.80.60.6-0.60.6-0.60.60.6-0.70.9
Total zone transitions, hab. session 22.33.04.11.51.51.51.22.01.9-2.02.0-1.91.91.9-0.5-2.0
Total locomotion distance, hab. session 22.83.64.61.81.91.91.72.12.1-2.12.2-2.12.12.1-1.1-1.3
Locomotion velocity, hab. session 22.12.83.71.51.61.61.41.91.9-1.91.9-1.91.91.9-0.8-1.3
Novel to familiar place preference ratio0.10.10.10.30.30.30.30.20.2-0.20.2-0.30.30.3-0.30.1
Novelty place preference0.00.00.10.20.10.00.1-0.1-0.10.1-0.10.0-0.00.0-0.30.1
Time in novel zone, NPP test0.00.00.10.10.10.10.1-0.1-0.10.1-0.10.0-0.0-0.0-0.20.3
Total zone transitions, NPP test5.98.610.43.23.12.82.93.13.1-3.13.1-3.03.03.1-2.4-1.6
Total locomotion distance, NPP test5.37.28.32.92.82.72.62.92.8-2.82.9-2.92.92.9-2.0-1.6
Locomotion velocity, NPP test5.78.19.73.13.02.82.63.03.0-3.03.0-3.03.03.0-2.1-2.1
Intraocular pressure0.50.71.5-1.2-1.0-0.6-0.8-0.8-0.80.8-0.80.7-0.7-0.70.91.2
Delta distance traveled before/after self-admin2.02.13.21.31.51.51.41.71.8-1.81.7-1.61.61.6-0.7-0.3
Delta ambulatory time before/after self-admin2.42.94.21.61.81.81.71.92.1-2.01.9-1.81.81.8-1.0-0.1
Parametrial fat weight3.99.211.62.93.03.12.73.43.4-3.33.4-3.43.43.4-1.6-1.5
Pavlov. Cond. lever latency3.03.77.1-2.5-2.3-2.1-2.4-1.7-1.71.7-1.71.7-1.7-1.72.70.1
Pavlov. Cond. magazine entry latency1.01.24.11.31.31.21.50.70.7-0.70.6-0.70.70.7-2.01.3
Pavlov. Cond. change in total contacts2.42.53.81.71.81.82.01.51.5-1.51.4-1.51.51.5-1.90.7
Pavlov. Cond. index score3.14.08.42.52.32.22.51.71.7-1.71.6-1.71.71.7-2.90.5
Pavlov. Cond. latency score2.32.97.72.32.11.82.31.41.3-1.31.3-1.31.31.4-2.80.7
Pavlov. Cond. lever contacts3.34.06.72.52.32.22.41.81.8-1.81.8-1.81.81.8-2.6-0.1
Pavlov. Cond. magazine entry number2.83.56.8-2.2-2.2-2.1-2.4-1.6-1.61.6-1.61.7-1.7-1.72.6-0.6
Pavlov. Cond. intertrial magazine entries0.91.11.4-1.2-1.2-1.1-1.1-1.1-1.11.1-1.11.1-1.1-1.11.10.3
Pavlov. Cond. lever-magazine prob. diff.2.93.67.82.42.22.12.41.61.6-1.61.5-1.61.61.6-2.80.6
Pavlov. Cond. response bias4.15.18.02.72.62.52.72.12.1-2.12.0-2.12.12.1-2.80.2
Pavlov. Cond. lever latency2.53.44.7-1.8-1.8-1.5-1.5-2.0-2.12.0-2.01.9-1.9-1.91.02.2
Pavlov. Cond. magazine entry latency2.42.93.51.81.71.61.51.91.8-1.91.9-1.81.81.8-1.2-1.5
Pavlov. Cond. change in total contacts2.23.55.51.91.81.61.42.02.1-2.12.0-1.91.91.9-0.9-2.3
Pavlov. Cond. index score4.15.66.82.52.42.22.12.62.6-2.62.5-2.42.42.4-1.6-2.2
Pavlov. Cond. latency score4.56.07.32.52.52.32.12.72.7-2.72.7-2.62.62.6-1.6-2.2
Pavlov. Cond. lever contacts2.83.85.22.01.91.71.52.22.2-2.22.1-2.02.02.0-1.0-2.3
Pavlov. Cond. magazine entry number0.81.01.8-1.2-1.0-0.7-0.8-1.0-1.01.0-1.01.0-1.0-1.00.91.3
Pavlov. Cond. intertrial magazine entries0.00.00.4-0.1-0.0-0.00.1-0.1-0.10.1-0.10.1-0.1-0.10.00.6
Pavlov. Cond. lever-magazine prob. diff.4.35.77.02.52.42.22.12.62.6-2.62.6-2.52.52.5-1.6-2.3
Pavlov. Cond. response bias1.11.54.31.31.10.80.81.31.4-1.31.3-1.21.21.2-0.6-2.1
Time in closed arm before self-admin0.10.20.8-0.5-0.5-0.2-0.6-0.2-0.20.2-0.1-0.00.00.10.8-0.9
Time in closed arm after self-admin0.90.95.4-0.6-0.5-0.2-0.90.40.4-0.30.4-0.50.50.52.0-2.3
Time in open arm before self-admin2.42.64.21.91.91.72.01.61.6-1.61.5-1.51.51.4-2.0-0.2
Time in open arm after self-admin1.01.03.41.11.11.01.40.70.7-0.70.5-0.40.40.4-1.81.6
Bone: periosteal estimation0.10.20.50.60.50.40.50.30.3-0.30.2-0.20.20.1-0.70.3
Bone: periosteal perimeter0.91.62.91.71.41.11.31.31.3-1.31.2-1.11.11.1-1.5-0.6
Bone: post-yield work0.10.21.5-0.2-0.2-0.0-0.40.30.3-0.30.3-0.20.20.20.7-1.2
Progressive ratio test 1 active lever presses0.81.01.40.80.91.00.71.21.2-1.21.1-1.11.11.1-0.3-1.1
Progressive ratio test 1 breakpoint0.80.91.20.80.81.00.71.11.1-1.11.1-1.11.11.1-0.3-1.0
Progressive ratio test 1 inactive lever presses0.81.21.61.11.11.31.21.11.1-1.11.1-1.21.21.2-1.1-0.3
Progressive ratio test 2 active lever presses2.83.34.41.91.92.11.91.91.9-1.91.9-1.91.91.9-1.8-0.4
Progressive ratio test 2 breakpoint3.23.74.82.02.02.22.02.02.0-2.02.0-1.91.91.9-1.9-0.5
Progressive ratio test 2 inactive lever presses0.81.32.01.11.11.41.11.11.2-1.11.2-1.31.31.3-1.0-0.2
Incentive Sensitization - Responses1.52.12.91.51.61.71.61.41.5-1.41.5-1.41.41.4-1.5-0.2
Incentive Sensitization - Breakpoint1.62.13.01.61.61.71.61.51.5-1.51.5-1.41.41.4-1.5-0.2
Sum of active levers in priming session hrs 5-60.90.85.80.40.50.51.0-0.3-0.30.3-0.30.2-0.2-0.1-1.72.4
Progressive ratio0.50.71.0-0.6-0.7-1.0-0.7-1.0-1.01.0-1.01.0-1.0-1.00.1-0.4
Food seeking constrained by brief footshock0.10.10.70.20.2-0.00.00.40.4-0.40.3-0.30.30.30.1-0.8
Seeking ratio, punishment vs. effort0.30.40.60.40.60.60.60.80.8-0.80.8-0.80.80.8-0.10.2
Retroperitoneal fat weight3.012.615.93.93.94.04.03.63.6-3.63.5-3.63.63.5-3.70.0
Reaction time number correct0.20.32.80.00.10.20.4-0.3-0.30.4-0.40.3-0.3-0.4-0.81.7
Reaction time mean minus median0.10.20.4-0.2-0.3-0.6-0.4-0.5-0.50.4-0.50.5-0.5-0.50.1-0.5
Reaction time mean minus median AUC0.30.71.0-0.8-0.9-1.0-1.0-0.7-0.80.7-0.80.8-0.8-0.81.0-0.9
Reaction time num false alarms0.60.81.2-0.9-1.0-1.1-0.9-1.0-0.90.9-1.01.0-1.0-1.00.60.2
Reaction time num false alarms AUC0.40.60.9-0.7-0.8-0.9-0.7-0.9-0.80.8-0.80.9-0.9-0.90.30.3
Reaction time trials correct on left0.20.32.80.00.10.20.4-0.3-0.30.4-0.40.3-0.3-0.4-0.81.7
Reaction time trials on left0.20.32.50.10.10.30.4-0.3-0.30.3-0.30.3-0.3-0.3-0.81.6
Reaction time mean0.60.95.4-0.8-0.9-0.8-1.2-0.3-0.30.3-0.30.2-0.2-0.31.5-2.3
Reaction time mean AUC0.61.06.0-0.8-0.9-0.8-1.3-0.3-0.30.2-0.20.2-0.2-0.21.7-2.4
Median of all reaction times0.70.96.0-0.8-0.8-0.7-1.2-0.2-0.20.2-0.10.0-0.0-0.11.7-2.4
Reaction time omissions0.30.41.10.70.60.50.40.60.7-0.60.6-0.60.60.6-0.4-1.1
Reaction time false alarm rate0.70.91.7-1.0-1.1-1.3-1.2-0.9-0.90.9-0.90.9-0.9-0.91.0-0.6
Reaction time premature initiation rate1.01.31.61.21.31.21.21.21.2-1.21.2-1.21.21.2-1.0-0.2
Reaction time premature initiations0.81.52.41.41.41.51.51.11.1-1.11.0-1.11.11.1-1.60.7
Std. dev. reaction times0.40.74.1-0.6-0.7-0.9-1.0-0.4-0.50.4-0.40.4-0.4-0.41.0-2.0
Reaction time trials completed0.20.32.50.10.10.30.4-0.3-0.30.3-0.30.3-0.3-0.3-0.81.6
Reaction time trials AUC0.20.32.50.20.30.50.6-0.1-0.10.2-0.20.1-0.1-0.1-0.91.6
Run reversals in cocaine runway, females1.31.32.71.41.21.21.31.01.0-1.01.0-1.01.01.0-1.7-0.2
Run reversals in cocaine runway, males0.10.10.30.20.30.40.40.50.3-0.30.3-0.40.40.3-0.50.5
Latency to leave start box in cocaine runway1.61.82.31.41.41.51.51.41.4-1.51.4-1.31.31.3-1.10.0
Latency to leave start box in cocaine runway, F0.30.30.60.50.50.50.40.80.6-0.80.7-0.50.50.50.10.1
Latency to leave start box in cocaine runway, M4.64.35.42.22.32.32.32.02.1-2.12.1-2.12.12.1-2.1-0.3
Std. dev. time between licks in bursts1.01.41.9-1.4-1.3-1.1-1.2-1.2-1.21.2-1.21.2-1.2-1.21.00.8
Total sessions with >9 infusions0.00.00.3-0.1-0.1-0.00.0-0.0-0.10.0-0.10.2-0.2-0.2-0.30.6
Short access day 1 total inactive lever presses0.20.30.40.50.50.60.60.50.5-0.50.6-0.60.60.6-0.40.0
Short access day 10 total inactive lever presses0.10.20.40.30.30.50.30.30.3-0.30.4-0.60.60.6-0.1-0.2
Short access day 1 total infusions0.10.20.4-0.4-0.4-0.4-0.3-0.4-0.40.4-0.40.5-0.5-0.50.10.6
Short access day 10 total infusions0.00.00.2-0.2-0.2-0.1-0.3-0.0-0.00.00.0-0.10.10.10.3-0.5
Short access total infusions0.60.71.0-1.0-1.0-0.8-0.9-0.9-0.90.8-0.90.9-0.9-0.90.70.4
Short access day 1 locomotion0.10.10.1-0.3-0.3-0.3-0.3-0.2-0.20.2-0.20.4-0.4-0.40.20.2
Short access day 10 total locomotion0.61.12.8-1.3-1.3-1.1-1.4-0.8-0.90.8-0.80.8-0.8-0.81.7-0.5
Short access total locomotion0.50.60.7-0.8-0.8-0.8-0.7-0.7-0.70.6-0.70.8-0.8-0.80.50.7
One hour access (0.3 mA shock)0.30.31.40.30.2-0.00.4-0.3-0.30.3-0.40.5-0.5-0.5-1.21.1
Compulsive drug intake0.20.20.6-0.2-0.2-0.2-0.1-0.6-0.50.6-0.50.4-0.4-0.4-0.30.8
One hour access (shock baseline)0.30.50.70.80.80.70.70.80.8-0.80.8-0.60.60.6-0.8-0.2
Social response proportion1.01.12.0-0.9-1.1-1.4-1.2-1.0-0.90.9-1.01.2-1.2-1.11.0-0.6
Social responses1.72.23.3-1.2-1.5-1.8-1.6-1.6-1.61.6-1.61.7-1.7-1.61.0-0.6
Social time1.01.34.6-0.2-0.4-0.8-0.1-1.2-1.21.2-1.21.3-1.3-1.3-1.02.1
Soleus weight0.51.52.41.61.41.21.31.11.1-1.11.1-1.21.21.2-1.4-0.3
Bone: stiffness0.00.00.20.0-0.1-0.1-0.10.10.1-0.10.00.1-0.1-0.10.2-0.4
Tibialis anterior weight0.20.81.20.80.81.00.80.90.9-0.90.9-1.11.11.0-0.5-0.3
Time to tail flick, vehicle, before self-admin0.10.10.4-0.2-0.4-0.2-0.4-0.5-0.60.6-0.50.2-0.2-0.3-0.1-0.4
Time to tail flick, vehicle, after self-admin3.24.26.7-2.1-2.2-2.3-2.5-2.0-1.91.9-1.91.8-1.8-1.82.6-1.5
Time to tail flick, test, before self-admin3.03.16.5-1.3-1.4-1.6-1.0-2.0-1.81.8-2.02.0-2.0-2.00.22.6
Time to tail flick, test, after self-admin1.61.62.3-1.1-1.2-1.5-1.1-1.4-1.41.3-1.41.5-1.5-1.50.70.1
Delta time to tail flick, vehicle, before/after SA1.41.32.0-1.1-1.2-1.4-1.2-1.2-1.11.1-1.11.2-1.2-1.21.2-0.2
Delta time to tail flick, test, before/after SA1.01.09.20.10.10.0-0.40.70.6-0.60.6-0.60.60.61.1-3.0
Tibia length2.98.010.83.23.23.23.32.82.8-2.82.7-2.82.82.7-3.00.3
Ambulatory time before self-admin0.10.10.70.10.00.00.2-0.2-0.30.3-0.30.2-0.2-0.2-0.60.9
Ambulatory time after self-admin2.22.63.41.61.81.71.81.71.7-1.71.6-1.51.51.5-1.60.6
Bone: tissue strength0.10.10.2-0.0-0.1-0.3-0.1-0.3-0.40.3-0.40.4-0.4-0.40.00.1
Total heroin consumption0.30.40.70.50.60.60.60.60.8-0.80.7-0.60.60.6-0.5-0.2
Bone: trabecular number0.81.32.2-1.1-1.3-1.2-1.5-1.0-1.01.0-1.00.9-0.9-1.01.4-1.3
Bone: trabecular spacing0.70.92.11.01.11.01.30.70.6-0.60.7-0.70.70.8-1.41.3
Bone: trabecular thickness1.41.73.1-1.4-1.5-1.4-1.7-1.1-1.11.1-1.11.2-1.2-1.21.7-1.0
Bone: trabecular tissue density0.60.88.10.10.20.40.7-0.3-0.40.4-0.30.2-0.2-0.2-1.12.8
Water consumed over 24 hours2.83.75.22.32.22.12.31.81.8-1.91.8-1.81.81.8-2.3-0.0
Number of responses in last shaping day0.10.10.20.30.30.20.30.10.2-0.10.1-0.10.10.1-0.50.5