Hub : Genes

Klc4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain isoform ratio XM_039083506.1 0.07 0.05 1.7e-05 0.04 0.03 0.04 0.05 3.2e-04 5.6e-04 7.2e-05 3.6e-05
2 BLA isoform ratio XM_006244516.4 0.06 0.04 4.0e-03 0.01 0.01 -0 0 7.8e-02 6.2e-02 9.6e-01 1.7e-01
3 Adipose gene expression Klc4 0.05 0.03 1.0e-05 0.02 0.04 0.03 0.03 1.7e-03 2.3e-05 2.4e-04 1.2e-04
4 Liver intron excision ratio chr9_14342948_14343345 0.03 0.02 1.3e-03 0.02 0.01 0.01 0.01 4.8e-03 1.3e-02 3.3e-02 1.8e-02
5 Liver intron excision ratio chr9_14343432_14344962 0.02 0.01 5.7e-03 0.01 0.01 0 0 1.7e-02 6.1e-02 2.8e-01 8.2e-02
6 Brain alternative TSS XM_006244517.4 0.03 0.02 7.4e-03 0.02 0.01 0 0.01 6.3e-03 3.5e-02 2.7e-01 3.3e-02
7 PL gene expression Klc4 0.15 0.08 0.0e+00 0.18 0.19 0.18 0.18 1.6e-19 1.7e-20 1.7e-19 7.8e-20
8 Brain gene expression Klc4 0.75 0.08 0.0e+00 0.64 0.66 0.67 0.66 8.1e-78 8.6e-82 9.2e-83 3.9e-82
9 LHb gene expression Klc4 0.27 0.13 1.6e-05 0.23 0.16 0.2 0.18 2.7e-06 1.2e-04 1.6e-05 3.7e-05
10 Brain mRNA stability Klc4 0.15 0.07 5.6e-17 0.18 0.18 0.19 0.2 6.3e-17 1.2e-16 2.2e-17 4.8e-18
11 IL gene expression Klc4 0.3 0.15 9.6e-06 0.23 0.19 0.17 0.21 2.5e-06 2.2e-05 5.3e-05 1.0e-05
12 BLA gene expression Klc4 0.14 0.08 4.5e-08 0.14 0.15 0.15 0.16 5.6e-08 1.5e-08 1.6e-08 8.1e-09
13 Liver gene expression Klc4 0.09 0.06 8.0e-06 0.05 0.04 0.05 0.05 1.2e-06 1.8e-05 6.5e-06 4.0e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.40.71.9-1.11.1-1.2-0.70.7-0.7-0.40.70.60.70.5-0.61.4
Area under the delay curve8.38.811.6-2.52.4-2.4-3.43.4-3.4-3.23.13.13.23.1-3.0-2.0
BMI with tail4.113.416.03.9-4.04.03.8-3.83.83.5-3.8-3.8-3.8-3.73.8-0.1
BMI without tail12.225.230.35.5-5.35.35.1-5.15.15.1-5.2-5.2-5.2-5.15.30.8
Body weight3.012.514.53.8-3.73.63.6-3.63.63.7-3.7-3.7-3.7-3.63.71.3
Weight adjusted by age0.20.20.30.5-0.50.60.2-0.20.20.4-0.4-0.5-0.4-0.50.50.2
Bone surface1.32.33.7-1.81.9-1.9-1.41.4-1.4-1.21.41.51.41.4-1.51.0
Bone volume0.50.91.6-1.21.2-1.3-0.90.9-0.9-0.70.90.90.90.8-0.90.9
Breakpoint value in progressive ratio session0.00.00.10.1-0.20.2-0.20.2-0.2-0.10.10.20.10.2-0.1-0.2
Number of licking bursts3.54.15.51.6-1.41.32.1-2.12.12.3-2.2-2.1-2.1-2.12.12.2
Context. condit. distance diff. score0.20.21.00.3-0.40.30.4-0.40.40.6-0.4-0.4-0.4-0.50.41.0
Locomotion velocity, session 10.70.81.71.1-1.31.30.7-0.70.70.5-0.7-0.6-0.7-0.70.7-1.3
Locomotion distance, session 12.32.93.51.8-1.91.81.8-1.81.81.8-1.8-1.7-1.8-1.71.60.5
Locomotion velocity, session 25.56.49.53.0-3.13.02.5-2.52.52.5-2.5-2.5-2.5-2.52.6-0.1
Locomotion distance, session 21.42.02.81.6-1.71.61.5-1.51.51.4-1.4-1.4-1.5-1.41.3-0.2
Locomotion velocity, session 30.60.71.61.1-1.31.30.5-0.50.50.5-0.6-0.6-0.6-0.60.7-1.3
Locomotion distance, session 30.80.81.7-0.70.5-0.5-1.01.0-1.0-1.01.00.90.90.9-1.0-1.3
Stereotopy head waving bouts, day 31.31.51.81.3-1.21.21.3-1.31.31.3-1.3-1.3-1.3-1.31.20.2
Stereotopy head waving duration, day 32.02.43.31.8-1.71.71.5-1.51.51.5-1.6-1.6-1.6-1.61.6-0.4
Locomotion velocity, session 70.40.41.60.9-1.01.00.4-0.40.40.2-0.4-0.4-0.4-0.40.3-1.2
Locomotion distance, session 70.20.31.40.6-0.70.70.3-0.30.30.1-0.2-0.2-0.3-0.30.1-1.2
Stereotopy head waving bouts, day 70.20.20.50.3-0.40.40.5-0.50.50.6-0.5-0.6-0.5-0.50.50.7
Stereotopy head waving duration, day 70.10.11.0-0.50.5-0.5-0.20.2-0.20.00.10.10.10.2-0.11.0
Locomotion velocity, session 80.50.61.00.9-1.00.90.7-0.70.70.9-0.7-0.8-0.7-0.70.80.3
Locomotion distance, session 81.11.62.01.2-1.41.31.3-1.31.31.4-1.3-1.3-1.3-1.41.10.7
Degree of sensitization distance1.91.92.61.6-1.51.51.5-1.51.51.3-1.4-1.4-1.4-1.41.3-0.0
Degree of sensitization stereotypy0.50.50.8-0.90.8-0.9-0.70.7-0.7-0.50.70.60.60.7-0.70.8
Conditioned locomotion1.72.04.3-0.80.8-0.7-1.51.5-1.5-1.71.51.41.51.5-1.5-2.1
Cocaine response after cond. corrected0.20.30.4-0.60.6-0.6-0.50.5-0.5-0.60.50.50.50.5-0.5-0.2
Cocaine response after cond. not corrected0.40.50.6-0.70.7-0.7-0.70.7-0.7-0.80.70.80.70.7-0.7-0.5
Cocaine response before conditioning0.10.10.50.4-0.50.50.2-0.20.20.0-0.1-0.0-0.1-0.00.1-0.7
Saline control response0.00.00.00.1-0.20.2-0.10.1-0.1-0.00.00.10.10.1-0.1-0.1
Bone: connectivity density0.91.53.3-1.61.8-1.8-0.90.9-0.9-0.70.91.00.90.8-1.01.7
Bone: cortical apparent density0.70.91.3-0.70.7-0.8-1.11.1-1.1-1.01.11.01.11.1-1.0-0.3
Bone: cortical area0.71.12.51.5-1.61.50.8-0.80.81.0-0.9-0.9-0.9-0.90.8-0.4
Bone: cortical porosity0.10.10.20.3-0.20.20.4-0.40.40.3-0.4-0.4-0.4-0.40.30.1
Bone: cortical porosity0.10.10.40.4-0.40.40.3-0.30.30.2-0.4-0.3-0.4-0.40.2-0.6
Bone: cortical thickness1.01.63.51.8-1.91.81.1-1.11.11.2-1.1-1.0-1.0-1.11.1-0.4
Bone: cortical thickness0.00.00.3-0.10.2-0.2-0.00.0-0.00.10.10.10.10.0-0.10.5
Bone: cortical tissue density0.60.81.1-0.70.7-0.7-1.11.1-1.1-0.91.00.91.01.0-0.9-0.3
Condit. Reinf. active minus inactive responses1.61.82.01.4-1.31.31.4-1.41.41.4-1.4-1.3-1.4-1.41.40.3
Condit. Reinf. active-inactive response ratio0.20.30.30.4-0.30.30.5-0.50.50.6-0.6-0.5-0.6-0.60.60.6
Condit. Reinf. active responses2.73.43.92.0-1.91.81.9-1.91.92.0-1.9-1.9-1.9-1.91.90.7
Condit. Reinf. inactive responses2.32.73.21.7-1.61.61.7-1.71.71.8-1.7-1.7-1.7-1.71.80.8
Incentive salience index mean2.22.63.81.9-1.91.91.6-1.61.61.6-1.6-1.6-1.6-1.61.70.1
Condit. Reinf. lever presses3.95.27.02.7-2.62.62.2-2.22.22.4-2.3-2.3-2.3-2.32.40.4
Condit. Reinf. active minus inactive responses0.10.10.9-0.30.3-0.40.0-0.00.00.2-0.1-0.1-0.0-0.00.10.9
Condit. Reinf. active-inactive response ratio0.70.72.20.3-0.30.20.9-0.90.91.0-0.9-0.8-0.9-0.80.91.5
Condit. Reinf. active responses0.00.00.1-0.20.2-0.2-0.10.1-0.10.00.00.00.10.10.00.4
Condit. Reinf. inactive responses0.10.10.50.2-0.20.2-0.30.3-0.3-0.30.20.20.30.2-0.1-0.7
Condit. Reinf. lever presses0.50.71.60.5-0.50.50.8-0.80.81.0-0.9-0.8-0.8-0.80.91.3
Condit. Reinf. lever reinforcers received0.00.00.2-0.20.2-0.2-0.10.1-0.1-0.00.10.10.20.1-0.00.5
Conditioned reinforcement - actives0.70.71.2-0.40.3-0.3-0.90.9-0.9-1.10.90.90.90.9-1.0-1.1
Conditioned reinforcement - inactives0.91.01.81.2-1.31.31.0-1.01.00.7-0.9-1.0-1.0-1.00.8-0.6
Conditioned locomotion0.00.00.1-0.0-0.10.10.1-0.10.10.0-0.1-0.2-0.2-0.2-0.10.3
Patch foraging indifference point 0 sec0.81.21.61.1-1.01.11.1-1.11.11.1-1.2-1.3-1.1-1.31.30.4
Patch foraging indifference point AUC1.11.33.01.7-1.61.70.7-0.70.70.6-0.8-0.8-0.8-0.80.9-1.7
Delay disc. indifference point, 0s delay1.71.93.0-1.21.1-1.0-1.51.5-1.5-1.51.31.31.41.3-1.1-1.7
Delay disc. indifference point, 16s delay11.311.513.6-3.13.0-2.9-3.73.7-3.7-3.73.63.63.73.6-3.5-1.7
Delay disc. indifference point, 2s delay3.43.85.4-1.51.5-1.4-2.32.3-2.3-2.12.02.02.02.0-1.8-1.9
Delay disc. indifference point, 24s delay1.41.41.8-1.11.1-1.2-1.31.3-1.3-1.11.31.31.31.3-1.0-0.0
Delay disc. indifference point, 4s delay3.23.36.1-1.00.8-0.7-2.22.2-2.2-2.11.81.81.91.7-1.9-2.5
Delay disc. indifference point, 8s delay5.15.27.1-1.81.7-1.7-2.72.7-2.7-2.52.42.42.42.3-2.4-1.8
Indifference point function ln k0.40.60.9-0.90.9-0.8-0.70.7-0.7-0.90.70.70.70.8-0.7-0.6
Indifference point function log k0.40.60.9-0.90.9-0.8-0.70.7-0.7-0.90.70.70.70.8-0.7-0.6
Patch foraging total patch changes 0 sec1.01.62.11.3-1.21.21.3-1.31.31.3-1.4-1.4-1.3-1.41.40.3
Patch foraging total patch changes 12 sec1.11.53.21.8-1.71.70.9-0.90.91.1-1.0-1.1-1.0-1.21.1-0.7
Patch foraging total patch changes 18 sec1.62.04.02.0-1.91.91.2-1.21.21.2-1.3-1.3-1.2-1.31.5-0.8
Patch foraging total patch changes 24 sec1.01.22.31.5-1.41.40.9-0.91.01.0-1.0-1.0-1.0-1.11.2-0.4
Patch foraging total patch changes 6 sec2.23.24.42.1-2.02.01.7-1.71.71.8-1.8-1.9-1.7-1.92.00.4
Patch foraging time to switch 0 sec4.77.310.7-3.23.2-3.3-2.72.7-2.6-2.32.72.72.72.7-2.71.3
Patch foraging water rate 0 sec3.15.010.02.9-3.13.21.9-1.91.91.5-1.9-2.0-1.9-1.91.9-2.4
Patch foraging water rate 12 sec5.48.311.03.3-3.33.32.9-2.92.92.7-2.9-2.9-2.9-2.92.9-0.4
Patch foraging water rate 18 sec1.31.72.61.6-1.61.61.2-1.21.21.1-1.3-1.3-1.2-1.31.3-0.5
Patch foraging water rate 24 sec2.02.83.91.8-1.92.01.7-1.71.61.4-1.7-1.8-1.7-1.71.6-0.9
Patch foraging water rate 6 sec0.40.72.91.0-1.11.20.5-0.50.50.3-0.4-0.5-0.5-0.50.4-1.7
Seeking ratio, delayed vs. immediate footshock2.02.23.2-1.71.7-1.7-1.51.5-1.5-1.51.51.51.41.5-1.80.0
Distance traveled before self-admin0.20.20.30.5-0.60.60.4-0.40.40.4-0.4-0.5-0.4-0.50.2-0.4
Distance traveled after self-admin3.74.15.12.0-2.12.12.1-2.12.12.0-2.2-2.2-2.2-2.32.1-0.3
Extensor digitorum longus weight0.10.40.60.7-0.80.70.6-0.60.60.6-0.6-0.6-0.6-0.60.6-0.2
Bone: elastic displacement0.30.40.6-0.40.5-0.5-0.70.7-0.7-0.50.70.70.70.7-0.50.0
Bone: elastic work0.10.10.90.2-0.10.00.0-0.00.00.4-0.0-0.1-0.0-0.10.21.0
Bone: endosteal estimation0.40.81.3-1.11.1-1.1-0.90.9-0.9-0.90.90.80.80.9-1.00.1
Bone: endosteal perimeter0.00.00.00.0-0.00.0-0.00.0-0.00.0-0.1-0.2-0.1-0.1-0.00.1
Epididymis fat weight2.04.76.31.9-1.81.72.2-2.22.22.5-2.3-2.2-2.2-2.22.32.3
Delta time in closed arm before/after self-admin0.30.31.7-0.10.0-0.00.5-0.50.50.5-0.5-0.5-0.6-0.50.31.3
Delta time in open arm before/after self-admin0.50.52.4-0.50.4-0.4-0.60.6-0.6-0.80.70.60.60.6-0.6-1.5
Diff in mean of infusions in LGA sessions0.40.51.10.9-1.01.10.6-0.60.60.5-0.6-0.6-0.6-0.50.50.0
Delay discount exponential model param8.18.611.62.4-2.32.33.4-3.43.43.1-3.1-3.1-3.1-3.02.91.9
Extinction: sum of active levers before priming0.00.00.10.2-0.10.10.0-0.00.00.0-0.1-0.0-0.10.00.0-0.3
Active lever presses in extinction session 60.10.10.50.6-0.70.70.0-0.00.00.1-0.1-0.1-0.10.00.2-0.5
Bone: final force0.40.71.01.0-1.00.90.8-0.80.81.0-0.8-0.9-0.8-0.80.70.7
Bone: final moment0.40.61.21.1-1.11.00.7-0.70.70.9-0.7-0.8-0.7-0.70.70.1
Food consumed during 24 hour testing period0.60.71.31.0-1.11.10.7-0.70.70.6-0.7-0.7-0.7-0.70.8-1.0
Glucose4.87.38.52.6-2.52.52.9-2.92.92.9-2.8-2.8-2.8-2.82.81.3
Heart weight1.21.72.2-1.11.0-1.0-1.31.3-1.3-1.51.41.51.41.5-1.5-1.0
Delay discount hyperbolic model param7.37.710.72.2-2.22.13.3-3.33.32.9-2.9-2.9-3.0-2.92.82.0
Intermittent access intake day 1-15 change0.10.10.30.5-0.60.60.2-0.20.20.1-0.1-0.1-0.1-0.10.1-0.1
Intermittent access intake escalation0.00.00.00.1-0.20.10.0-0.00.0-0.00.10.10.10.1-0.10.1
Intermittent access intake escalation 20.10.10.40.6-0.60.60.2-0.20.20.2-0.2-0.2-0.2-0.20.1-0.4
Intermitt. access day 1 inactive lever presses1.51.62.11.2-1.31.31.5-1.51.51.2-1.3-1.3-1.3-1.31.30.1
Intermitt. access day 15 inactive lever presses2.02.23.01.3-1.51.51.7-1.71.71.4-1.6-1.5-1.5-1.51.4-0.1
Intermitt. access escalation Index0.00.00.1-0.20.3-0.20.0-0.00.0-0.10.00.00.00.0-0.1-0.3
Intermittent access day 1 total infusions0.70.91.20.5-0.50.51.1-1.11.10.9-1.0-1.1-1.1-1.10.81.1
Intermittent access day 15 total infusions0.50.50.80.4-0.40.40.9-0.90.90.7-0.8-0.8-0.8-0.80.50.9
Intermittent access terminal intake (last 3 days)0.30.41.00.1-0.20.20.7-0.70.70.6-0.6-0.7-0.6-0.70.31.0
Intermittent access total infusions0.30.31.1-0.10.0-0.00.7-0.70.70.4-0.5-0.6-0.5-0.60.31.1
Intermittent access day 1 locomotion0.30.40.60.0-0.00.00.7-0.70.70.6-0.7-0.8-0.7-0.80.60.6
Intermittent access day 15 total locomotion0.40.40.50.5-0.60.50.7-0.70.70.6-0.7-0.7-0.7-0.70.60.1
Intermittent access total locomotion0.10.20.8-0.40.4-0.40.4-0.40.40.3-0.3-0.3-0.3-0.30.20.9
Intermittent access standard deviation3.13.34.7-2.22.1-2.2-1.81.8-1.8-1.61.81.81.81.8-1.90.9
Left kidney weight0.30.72.01.3-1.41.40.6-0.60.60.5-0.5-0.6-0.5-0.50.5-1.2
Right kidney weight0.20.43.40.8-0.91.0-0.10.1-0.0-0.2-0.0-0.0-0.00.00.0-1.8
Cocaine induced anxiety0.10.10.30.1-0.10.10.4-0.40.40.4-0.4-0.3-0.3-0.30.40.5
Post-drug Anxiety0.10.21.6-0.30.4-0.40.1-0.10.10.20.00.10.10.10.11.2
Baseline Anxiety0.20.20.3-0.40.4-0.5-0.40.4-0.4-0.40.60.60.60.6-0.50.3
Tail length1.85.67.22.7-2.42.32.3-2.32.32.7-2.4-2.4-2.4-2.42.41.7
Length with tail0.10.41.90.8-0.60.40.4-0.40.40.9-0.5-0.5-0.4-0.50.41.4
Length without tail2.65.66.5-2.42.4-2.5-2.52.5-2.5-2.22.52.52.52.5-2.60.1
Times rat made contact with spout4.55.26.52.2-2.01.92.4-2.42.42.6-2.4-2.5-2.4-2.52.51.4
Lifetime Intake0.10.10.3-0.50.4-0.40.1-0.10.1-0.10.0-0.00.0-0.0-0.30.5
Liver weight, left0.40.71.41.1-1.21.20.7-0.70.70.6-0.7-0.7-0.7-0.60.6-0.9
Liver weight, right0.50.91.31.1-1.00.90.9-0.90.91.2-0.9-0.9-0.9-0.90.90.8
Locomotor activity2.13.34.61.7-1.61.51.9-1.91.92.2-1.9-1.9-1.8-1.91.91.8
Locomotor testing distance1.83.14.31.6-1.51.41.8-1.81.82.1-1.8-1.8-1.7-1.81.91.8
Locomotor testing rearing3.24.96.42.5-2.52.52.2-2.22.22.2-2.2-2.3-2.2-2.32.40.0
Locomotion in novel chamber0.70.91.2-0.80.7-0.8-1.01.0-1.0-1.01.01.01.00.9-1.1-0.6
Locomotion in novel chamber post-restriction1.21.43.4-0.80.5-0.5-1.11.1-1.1-1.51.21.31.21.3-1.3-1.9
Fecal boli incidents, locomotor time 10.50.52.70.0-0.10.0-0.50.5-0.5-0.70.70.70.80.7-0.7-1.6
Change in fecal boli incidents, locomotor task0.10.10.20.0-0.00.1-0.30.3-0.3-0.40.20.20.20.2-0.2-0.4
Time >=10cm from walls, locomotor time 10.40.40.70.8-0.80.90.6-0.60.60.4-0.6-0.6-0.5-0.70.4-0.6
Bouts of movement, locomotor time 10.10.10.5-0.70.7-0.70.0-0.00.1-0.20.00.00.1-0.0-0.3-0.3
Total resting periods, locomotor time 10.20.20.3-0.10.2-0.10.5-0.50.60.4-0.6-0.5-0.5-0.60.3-0.2
Rest time, locomotor task time 10.60.71.0-0.70.7-0.7-0.80.8-0.8-1.00.80.80.90.8-0.9-1.0
Distance moved, locomotor task time 10.00.00.2-0.0-0.00.0-0.00.0-0.10.2-0.1-0.2-0.2-0.20.20.4
Vertical activity count, locomotor time 10.70.71.2-0.80.7-0.7-1.11.1-1.1-0.70.90.90.90.9-0.7-0.1
Time >=10cm from walls, locomotor time 20.70.71.41.1-1.11.20.6-0.60.60.5-0.8-0.8-0.7-0.90.5-0.9
Bouts of movement, locomotor time 20.40.40.70.4-0.50.50.6-0.60.70.7-0.7-0.8-0.7-0.80.60.9
Total resting periods, locomotor time 20.10.21.0-0.1-0.10.00.3-0.30.30.3-0.4-0.4-0.3-0.40.21.0
Rest time, locomotor task time 20.60.71.2-0.91.1-1.1-0.80.8-0.9-0.70.80.80.80.8-0.90.3
Distance moved, locomotor task time 21.01.11.50.9-1.01.01.1-1.11.11.0-1.2-1.2-1.2-1.21.1-0.3
Vertical activity count, locomotor time 20.20.20.5-0.20.1-0.0-0.50.5-0.5-0.50.40.40.40.4-0.2-0.7
Light reinforcement 12.03.74.72.1-2.22.22.0-2.01.91.9-1.9-2.0-1.9-2.01.90.1
Light reinforcement 22.73.64.51.5-1.51.42.1-2.12.12.1-2.0-2.0-2.0-2.01.71.8
Bone: marrow area0.41.01.3-1.11.2-1.1-1.01.0-1.0-1.00.90.90.90.9-1.00.1
Bone: maximum diameter0.30.51.11.0-1.01.00.5-0.50.50.4-0.5-0.6-0.5-0.50.5-0.9
Bone: maximum force0.10.11.40.1-0.0-0.10.2-0.20.20.4-0.2-0.2-0.2-0.20.11.2
Bone: maximum moment0.00.00.40.1-0.10.10.1-0.10.10.3-0.1-0.1-0.1-0.10.00.6
Mean time between licks in bursts1.52.13.9-1.92.0-1.9-1.31.3-1.3-1.31.31.31.31.3-1.30.6
Mean num. licks in bursts0.50.62.1-0.50.4-0.3-0.80.8-0.8-1.00.80.70.80.7-0.8-1.5
Cd content in liver1.11.22.7-0.90.8-0.7-1.11.1-1.1-1.31.01.11.01.0-1.1-1.6
Co content in liver0.00.00.20.1-0.10.10.2-0.20.2-0.0-0.2-0.2-0.2-0.20.2-0.5
Cu content in liver0.70.82.9-0.40.2-0.2-1.01.0-1.0-1.00.90.80.90.9-0.9-1.7
Fe content in liver0.30.40.6-0.60.6-0.6-0.60.6-0.6-0.50.70.80.70.6-0.80.5
K content in liver0.90.93.3-1.21.4-1.4-0.60.6-0.6-0.30.60.60.60.6-0.61.8
Mg content in liver1.91.92.3-1.41.4-1.4-1.51.5-1.5-1.31.51.51.51.5-1.40.1
Mn content in liver0.70.81.20.6-0.50.61.0-1.01.00.8-1.0-1.1-1.0-1.01.10.1
Na content in liver0.10.10.20.5-0.50.40.1-0.10.10.4-0.1-0.2-0.1-0.10.20.4
Rb content in liver6.17.69.0-2.72.6-2.6-2.92.9-2.9-2.82.93.02.92.9-3.0-0.7
Se content in liver0.20.20.90.5-0.50.60.3-0.30.30.1-0.4-0.4-0.4-0.40.4-0.9
Sr content in liver0.80.71.00.9-0.91.00.9-0.90.90.7-0.9-0.9-0.9-0.90.9-0.6
Zn content in liver4.44.97.2-1.71.5-1.4-2.22.2-2.2-2.62.32.42.32.3-2.3-2.7
Bone: minimum diameter0.30.50.80.8-0.90.90.7-0.70.70.7-0.8-0.8-0.8-0.80.5-0.2
Time in familiar zone, hab. session 10.90.81.81.2-1.31.30.8-0.80.80.6-0.7-0.7-0.8-0.80.8-1.1
Time in novel zone, hab. session 11.01.01.7-1.21.3-1.3-0.90.9-0.9-0.90.90.90.90.9-1.00.1
Total zone transitions, hab. session 14.36.06.92.6-2.52.52.6-2.62.62.5-2.5-2.5-2.5-2.52.30.8
Total locomotion distance, hab. session 14.46.28.12.8-2.92.82.5-2.52.52.5-2.5-2.5-2.5-2.52.50.1
Locomotion velocity, hab. session 13.95.67.62.7-2.82.72.4-2.42.42.4-2.4-2.4-2.4-2.32.30.1
Time in familiar zone, hab. session 22.02.02.9-1.61.6-1.7-1.41.4-1.4-1.21.41.41.41.5-1.50.7
Time in novel zone, hab. session 20.40.41.00.7-0.70.80.6-0.60.60.3-0.6-0.6-0.6-0.60.6-1.0
Total zone transitions, hab. session 22.73.54.81.5-1.31.32.0-2.02.02.2-2.0-2.0-2.0-2.01.92.0
Total locomotion distance, hab. session 23.04.04.71.8-1.71.72.2-2.22.22.2-2.1-2.1-2.1-2.12.11.2
Locomotion velocity, hab. session 22.33.13.81.5-1.51.51.9-1.91.92.0-1.9-1.9-1.9-1.91.91.2
Novel to familiar place preference ratio0.10.10.20.4-0.30.30.3-0.30.30.3-0.3-0.4-0.2-0.30.40.0
Novelty place preference0.00.00.00.2-0.20.10.0-0.00.00.10.0-0.10.00.00.10.0
Time in novel zone, NPP test0.00.00.00.1-0.10.10.0-0.00.00.00.0-0.10.00.00.1-0.2
Total zone transitions, NPP test6.89.711.53.2-3.13.03.3-3.33.33.4-3.2-3.2-3.2-3.23.11.6
Total locomotion distance, NPP test5.98.09.62.8-2.72.73.0-3.03.03.1-2.9-3.0-2.9-2.92.91.6
Locomotion velocity, NPP test6.49.111.42.9-2.92.83.1-3.13.13.4-3.1-3.1-3.1-3.03.12.1
Intraocular pressure0.91.21.9-1.11.2-1.1-1.01.0-1.0-1.41.11.11.11.1-1.2-1.3
Delta distance traveled before/after self-admin4.34.66.32.1-1.91.92.3-2.32.32.3-2.4-2.3-2.3-2.42.50.5
Delta ambulatory time before/after self-admin3.53.95.22.0-1.71.82.0-2.02.02.1-2.2-2.1-2.1-2.22.30.4
Parametrial fat weight6.111.813.83.6-3.33.33.6-3.63.53.7-3.6-3.5-3.6-3.63.71.7
Pavlov. Cond. lever latency2.63.25.4-2.32.3-2.3-1.71.7-1.7-1.71.71.71.71.7-1.70.2
Pavlov. Cond. magazine entry latency0.91.22.71.5-1.61.60.9-0.90.90.6-0.8-0.8-0.8-0.80.8-1.4
Pavlov. Cond. change in total contacts2.12.33.61.8-1.91.91.5-1.51.51.3-1.5-1.4-1.5-1.51.4-0.7
Pavlov. Cond. index score2.73.56.32.4-2.52.51.7-1.71.71.6-1.7-1.7-1.7-1.71.7-0.7
Pavlov. Cond. latency score2.02.55.12.1-2.32.21.4-1.41.41.3-1.4-1.4-1.4-1.41.3-0.8
Pavlov. Cond. lever contacts3.64.36.62.5-2.62.52.0-2.02.02.0-2.0-2.0-2.0-2.02.0-0.0
Pavlov. Cond. magazine entry number2.02.54.5-2.02.1-2.1-1.51.5-1.5-1.31.41.41.41.4-1.40.8
Pavlov. Cond. intertrial magazine entries0.91.01.3-1.11.2-1.2-1.11.1-1.1-1.01.01.01.01.0-1.10.0
Pavlov. Cond. lever-magazine prob. diff.2.63.25.82.3-2.42.41.7-1.71.71.5-1.7-1.6-1.7-1.71.6-0.8
Pavlov. Cond. response bias4.35.37.92.7-2.82.82.3-2.32.32.1-2.3-2.2-2.3-2.22.2-0.4
Pavlov. Cond. lever latency2.53.34.4-1.51.5-1.4-1.91.9-1.9-2.11.91.81.91.8-1.9-2.1
Pavlov. Cond. magazine entry latency1.82.12.81.3-1.31.21.6-1.61.61.7-1.5-1.4-1.5-1.41.51.5
Pavlov. Cond. change in total contacts2.43.34.71.5-1.51.41.8-1.81.82.1-1.8-1.8-1.8-1.81.92.2
Pavlov. Cond. index score4.55.87.42.2-2.22.12.5-2.52.52.7-2.5-2.4-2.5-2.42.52.1
Pavlov. Cond. latency score4.96.17.72.3-2.22.12.6-2.62.62.8-2.6-2.5-2.5-2.52.52.1
Pavlov. Cond. lever contacts2.83.85.11.7-1.61.52.0-2.02.02.3-2.0-1.9-2.0-1.92.02.1
Pavlov. Cond. magazine entry number0.91.12.0-1.00.9-0.8-1.11.1-1.1-1.21.00.91.00.9-1.0-1.4
Pavlov. Cond. intertrial magazine entries0.00.00.50.0-0.00.1-0.10.1-0.1-0.20.0-0.00.0-0.0-0.0-0.7
Pavlov. Cond. lever-magazine prob. diff.4.55.77.42.2-2.12.02.5-2.52.52.7-2.5-2.4-2.4-2.42.52.2
Pavlov. Cond. response bias1.01.43.80.9-0.90.81.1-1.11.11.5-1.1-1.1-1.1-1.11.22.0
Time in closed arm before self-admin0.20.20.7-0.70.8-0.8-0.20.2-0.2-0.30.40.40.50.4-0.30.5
Time in closed arm after self-admin0.30.32.4-0.70.8-0.80.2-0.20.20.1-0.1-0.0-0.1-0.20.01.6
Time in open arm before self-admin2.83.04.82.1-2.22.21.6-1.61.61.6-1.8-1.8-1.8-1.71.50.1
Time in open arm after self-admin0.70.81.91.2-1.21.20.6-0.60.60.5-0.7-0.8-0.8-0.70.5-1.4
Bone: periosteal estimation0.10.10.30.5-0.60.50.2-0.20.20.2-0.2-0.3-0.3-0.20.1-0.5
Bone: periosteal perimeter0.61.11.61.2-1.31.21.0-1.01.01.1-1.0-1.1-1.0-1.00.90.4
Bone: post-yield work0.10.10.8-0.30.4-0.40.2-0.20.20.1-0.1-0.1-0.1-0.1-0.00.9
Progressive ratio test 1 active lever presses1.31.42.50.7-0.60.61.3-1.31.31.2-1.2-1.2-1.2-1.21.21.6
Progressive ratio test 1 breakpoint1.11.11.50.7-0.70.71.2-1.21.21.1-1.1-1.1-1.1-1.11.11.2
Progressive ratio test 1 inactive lever presses1.11.21.61.1-1.21.21.3-1.31.31.0-1.2-1.2-1.2-1.21.00.1
Progressive ratio test 2 active lever presses1.41.51.91.2-1.31.31.4-1.41.41.1-1.3-1.3-1.3-1.31.10.3
Progressive ratio test 2 breakpoint2.02.22.71.5-1.61.61.7-1.71.71.4-1.6-1.6-1.6-1.61.40.3
Progressive ratio test 2 inactive lever presses0.60.71.10.8-0.90.91.0-1.01.00.7-0.9-0.9-0.9-0.90.60.1
Incentive Sensitization - Responses1.41.41.91.2-1.41.41.3-1.31.31.0-1.2-1.2-1.2-1.21.0-0.1
Incentive Sensitization - Breakpoint1.41.42.01.2-1.41.41.3-1.31.31.0-1.2-1.2-1.2-1.21.0-0.1
Sum of active levers in priming session hrs 5-61.01.03.3-0.30.2-0.1-0.90.9-0.9-1.21.01.01.01.1-0.9-1.8
Progressive ratio0.60.71.0-0.60.7-0.7-1.01.0-1.0-0.61.00.91.00.9-0.80.4
Food seeking constrained by brief footshock0.00.00.30.0-0.00.00.1-0.10.10.3-0.2-0.1-0.2-0.10.30.6
Seeking ratio, punishment vs. effort0.50.70.90.7-0.70.80.9-0.90.90.7-0.9-0.8-1.0-0.80.8-0.3
Retroperitoneal fat weight1.75.68.52.8-2.92.92.3-2.32.32.2-2.3-2.3-2.3-2.32.3-0.6
Reaction time number correct0.20.42.90.3-0.30.4-0.40.4-0.4-0.60.30.40.30.4-0.3-1.7
Reaction time mean minus median0.10.20.4-0.30.3-0.4-0.50.5-0.4-0.20.50.50.40.5-0.40.6
Reaction time mean minus median AUC0.50.60.9-0.90.9-1.0-0.80.8-0.7-0.50.80.80.80.8-0.70.9
Reaction time num false alarms0.60.91.1-1.01.0-1.0-1.01.0-1.0-0.91.01.01.00.9-1.1-0.1
Reaction time num false alarms AUC0.50.60.8-0.80.7-0.7-0.80.8-0.8-0.80.80.90.90.8-0.9-0.3
Reaction time trials correct on left0.20.42.90.3-0.30.4-0.40.4-0.4-0.60.30.40.30.4-0.3-1.7
Reaction time trials on left0.20.32.50.3-0.40.4-0.30.3-0.3-0.50.30.40.30.3-0.2-1.6
Reaction time mean0.50.85.7-1.11.1-1.2-0.20.2-0.10.10.30.40.30.3-0.32.4
Reaction time mean AUC0.60.86.2-1.11.1-1.2-0.10.1-0.00.10.20.30.20.3-0.32.5
Median of all reaction times0.50.75.8-0.91.0-1.00.1-0.10.10.20.00.20.00.1-0.22.4
Reaction time omissions0.50.71.10.6-0.60.50.9-0.90.90.9-0.8-0.8-0.8-0.80.81.1
Reaction time false alarm rate0.60.91.4-1.21.2-1.2-0.90.9-0.9-0.80.90.90.90.8-1.00.6
Reaction time premature initiation rate1.01.41.61.2-1.21.21.3-1.31.31.2-1.2-1.2-1.2-1.31.10.4
Reaction time premature initiations1.01.42.31.5-1.51.51.1-1.11.10.9-1.1-1.1-1.1-1.11.1-0.6
Std. dev. reaction times0.40.64.2-0.80.8-0.9-0.40.4-0.3-0.00.40.50.40.4-0.42.1
Reaction time trials completed0.20.32.50.3-0.40.4-0.30.3-0.3-0.50.30.40.30.3-0.2-1.6
Reaction time trials AUC0.20.32.50.4-0.50.6-0.20.2-0.2-0.40.20.20.20.2-0.1-1.6
Run reversals in cocaine runway, females0.70.71.41.1-1.21.20.7-0.70.70.8-0.7-0.7-0.7-0.70.70.1
Run reversals in cocaine runway, males0.10.10.30.1-0.30.40.4-0.40.40.1-0.3-0.3-0.3-0.30.1-0.5
Latency to leave start box in cocaine runway2.22.43.01.6-1.71.71.6-1.61.61.4-1.7-1.5-1.7-1.61.4-0.4
Latency to leave start box in cocaine runway, F0.20.30.50.3-0.40.40.6-0.60.60.5-0.7-0.5-0.7-0.60.4-0.3
Latency to leave start box in cocaine runway, M5.14.96.92.6-2.62.62.3-2.32.32.0-2.2-2.2-2.2-2.22.1-0.3
Std. dev. time between licks in bursts1.61.92.5-1.41.4-1.3-1.41.4-1.4-1.61.41.41.41.4-1.4-0.8
Total sessions with >9 infusions0.00.00.0-0.1-0.10.10.1-0.10.1-0.2-0.0-0.1-0.1-0.1-0.1-0.2
Short access day 1 total inactive lever presses0.20.21.00.4-0.60.70.3-0.30.30.0-0.3-0.3-0.3-0.30.2-1.0
Short access day 10 total inactive lever presses1.01.11.81.2-1.31.41.1-1.11.10.8-1.0-1.0-1.0-1.00.9-0.9
Short access day 1 total infusions0.30.30.5-0.50.4-0.4-0.50.5-0.5-0.70.50.50.50.5-0.6-0.5
Short access day 10 total infusions0.20.21.4-0.40.4-0.40.4-0.40.40.2-0.2-0.2-0.2-0.20.11.2
Short access total infusions0.30.30.8-0.90.8-0.8-0.40.4-0.4-0.60.50.50.50.5-0.60.3
Short access day 1 locomotion0.50.60.8-0.90.8-0.8-0.70.7-0.7-0.80.70.70.70.7-0.9-0.1
Short access day 10 total locomotion2.12.44.3-2.02.0-2.1-1.41.4-1.4-1.31.51.41.51.4-1.40.7
Short access total locomotion2.02.02.5-1.61.5-1.5-1.41.4-1.4-1.51.41.41.41.4-1.5-0.7
One hour access (0.3 mA shock)0.30.31.2-0.0-0.00.0-0.60.6-0.6-0.60.60.50.50.5-0.6-1.1
Compulsive drug intake0.20.21.70.2-0.30.3-0.40.4-0.4-0.30.30.30.30.3-0.1-1.3
One hour access (shock baseline)0.30.30.50.4-0.30.30.6-0.60.60.6-0.6-0.6-0.6-0.60.40.7
Social response proportion0.80.91.2-1.11.0-1.1-0.90.9-0.9-0.80.91.00.91.0-1.10.4
Social responses1.92.53.2-1.61.5-1.6-1.61.6-1.6-1.51.71.71.71.7-1.80.4
Social time1.51.96.0-0.50.3-0.3-1.31.3-1.4-1.51.41.51.41.4-1.6-2.4
Soleus weight0.41.21.61.3-1.21.21.1-1.11.11.2-1.1-1.1-1.1-1.01.00.6
Bone: stiffness0.00.00.4-0.20.2-0.2-0.00.0-0.00.1-0.00.0-0.0-0.0-0.10.6
Tibialis anterior weight0.20.60.70.6-0.60.60.8-0.80.80.8-0.9-0.8-0.9-0.80.80.5
Time to tail flick, vehicle, before self-admin0.20.20.4-0.50.3-0.4-0.30.3-0.3-0.40.40.60.40.5-0.60.7
Time to tail flick, vehicle, after self-admin2.93.14.5-2.12.1-2.1-1.71.7-1.7-1.31.71.71.81.7-1.51.6
Time to tail flick, test, before self-admin5.04.96.1-1.71.6-1.5-2.42.4-2.4-2.52.32.42.32.3-2.4-2.2
Time to tail flick, test, after self-admin0.70.71.1-0.50.6-0.7-1.11.1-1.1-0.70.90.90.91.0-0.70.1
Delta time to tail flick, vehicle, before/after SA0.80.71.0-0.91.0-1.0-1.01.0-1.0-0.60.90.81.01.0-0.50.3
Delta time to tail flick, test, before/after SA1.61.47.70.5-0.30.20.9-0.90.91.4-1.0-1.1-1.0-1.01.22.8
Tibia length2.26.38.92.9-3.03.02.5-2.52.52.4-2.5-2.6-2.5-2.42.6-0.5
Ambulatory time before self-admin0.10.10.60.1-0.30.3-0.20.2-0.2-0.20.20.10.10.1-0.2-0.8
Ambulatory time after self-admin3.43.84.72.1-2.02.01.9-1.91.92.0-2.1-2.1-2.1-2.22.1-0.0
Bone: tissue strength0.10.10.2-0.20.1-0.1-0.40.4-0.4-0.30.40.30.40.4-0.3-0.2
Total heroin consumption0.10.10.40.2-0.20.20.3-0.30.30.3-0.4-0.4-0.5-0.4-0.10.6
Bone: trabecular number0.50.71.2-1.01.0-1.1-0.70.7-0.7-0.60.80.80.80.7-0.91.0
Bone: trabecular spacing0.60.81.51.1-1.21.20.7-0.70.70.5-0.7-0.8-0.7-0.70.7-1.2
Bone: trabecular thickness0.81.01.8-1.31.3-1.3-0.90.9-0.9-0.80.90.90.90.8-0.90.8
Bone: trabecular tissue density0.50.77.00.3-0.40.6-0.30.3-0.3-0.80.30.20.30.3-0.3-2.6
Water consumed over 24 hours2.22.64.22.0-2.02.01.5-1.51.51.6-1.5-1.6-1.5-1.61.6-0.3
Number of responses in last shaping day0.20.20.40.5-0.60.60.3-0.30.30.2-0.3-0.4-0.3-0.40.2-0.6