Hub : Genes

Klc3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative TSS NM_138520.2 0.02 0.02 4.4e-03 0 0.01 0.01 0 1.7e-01 3.6e-02 2.6e-02 8.2e-02
2 Brain gene expression Klc3 0.21 0.19 6.2e-07 0.06 0.06 0.06 0.06 1.2e-06 2.1e-06 3.5e-06 1.4e-06
3 PL gene expression Klc3 0.05 0.05 4.2e-06 0.04 0.05 0.04 0.04 1.1e-05 7.0e-06 2.7e-05 1.5e-05
4 Brain mRNA stability Klc3 0.21 0.2 2.8e-07 0.07 0.07 0.07 0.07 5.2e-07 2.4e-07 3.0e-07 2.8e-07
5 PL alternative TSS NM_138520.2 0.03 0.06 8.9e-03 0.02 0.01 0.02 0.02 4.3e-03 7.6e-03 7.0e-03 5.4e-03
6 PL alternative TSS XM_006228379.5 0.04 0.09 8.6e-03 0.01 0.01 0.01 0.01 1.0e-02 3.4e-02 1.3e-02 2.2e-02
7 NAcc gene expression Klc3 0.06 0.05 1.7e-08 0.05 0.05 0.04 0.05 6.6e-08 5.1e-08 1.9e-07 7.1e-08
8 Adipose gene expression Klc3 0.08 0.06 9.7e-09 0.05 0.07 0.08 0.08 3.4e-06 1.7e-08 1.7e-09 2.7e-09
9 Liver alternative TSS XM_006228379.5 0.02 0.02 3.9e-03 0.01 0.01 0 0.01 2.0e-02 3.5e-02 7.5e-02 5.7e-02
10 pVTA gene expression Klc3 0.06 0.06 9.7e-04 0.02 0.02 0.02 0.02 6.7e-03 8.5e-03 5.9e-03 1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.00.00.1-0.3-0.1-0.0-0.30.20.20.10.2-0.2-0.1
Area under the delay curve1.82.12.71.7-1.4-1.4-1.31.51.5-1.4-1.61.6-1.1
BMI with tail0.51.92.4-1.61.51.41.3-1.2-1.21.41.5-1.41.2
BMI without tail0.61.82.1-1.31.41.41.4-1.3-1.31.31.3-1.41.1
Body weight1.14.75.4-2.32.32.22.1-2.1-2.12.22.2-2.11.8
Weight adjusted by age0.00.00.00.10.10.00.10.00.00.0-0.00.00.1
Bone surface0.30.50.9-1.00.60.70.4-0.6-0.60.70.9-0.80.5
Bone volume0.20.30.7-0.80.40.50.3-0.4-0.40.60.7-0.80.3
Breakpoint value in progressive ratio session2.12.52.81.6-1.7-1.7-1.61.51.5-1.7-1.61.6-1.4
Number of licking bursts2.23.65.2-1.72.11.92.3-2.1-2.11.81.7-1.51.7
Context. condit. distance diff. score0.10.10.2-0.40.30.30.3-0.3-0.30.30.4-0.40.3
Locomotion velocity, session 10.10.10.10.3-0.3-0.3-0.20.30.3-0.3-0.30.3-0.1
Locomotion distance, session 10.00.00.1-0.30.10.20.1-0.1-0.10.30.2-0.40.1
Locomotion velocity, session 21.21.41.8-1.01.21.21.4-1.2-1.21.21.1-1.11.0
Locomotion distance, session 20.30.40.7-0.80.50.70.5-0.5-0.50.70.7-0.80.5
Locomotion velocity, session 30.20.20.3-0.40.50.50.5-0.4-0.40.50.4-0.50.4
Locomotion distance, session 30.70.80.91.0-0.9-0.9-0.90.90.9-0.9-0.90.8-0.7
Stereotopy head waving bouts, day 30.81.01.5-0.71.11.01.2-1.1-1.10.90.8-0.70.9
Stereotopy head waving duration, day 31.01.21.5-1.01.21.11.2-1.2-1.21.11.0-1.00.9
Locomotion velocity, session 70.10.10.30.2-0.4-0.4-0.60.40.4-0.3-0.20.1-0.3
Locomotion distance, session 70.00.00.1-0.30.20.20.1-0.2-0.20.20.3-0.30.2
Stereotopy head waving bouts, day 70.91.01.2-1.01.01.01.0-1.1-1.11.01.0-1.00.8
Stereotopy head waving duration, day 70.70.81.0-0.91.00.91.0-1.0-1.00.90.9-0.80.7
Locomotion velocity, session 80.00.00.00.2-0.1-0.00.10.10.1-0.1-0.10.10.0
Locomotion distance, session 80.00.00.2-0.3-0.00.1-0.10.00.00.20.2-0.40.1
Degree of sensitization distance0.60.60.7-0.80.80.80.8-0.8-0.80.80.8-0.80.7
Degree of sensitization stereotypy1.01.01.2-1.11.01.01.0-1.1-1.11.01.0-1.00.8
Conditioned locomotion0.00.00.10.2-0.2-0.2-0.20.30.3-0.2-0.20.2-0.2
Cocaine response after cond. corrected0.60.71.0-1.00.80.80.7-0.9-0.90.91.0-0.80.7
Cocaine response after cond. not corrected1.51.82.4-1.61.31.31.2-1.3-1.31.31.5-1.31.1
Cocaine response before conditioning1.51.82.0-1.31.41.41.4-1.3-1.31.41.3-1.41.1
Saline control response2.02.72.9-1.71.61.71.7-1.7-1.71.71.6-1.71.3
Bone: connectivity density0.00.10.2-0.1-0.3-0.2-0.40.30.3-0.10.0-0.1-0.2
Bone: cortical apparent density0.10.10.20.4-0.4-0.3-0.50.40.4-0.3-0.40.1-0.4
Bone: cortical area1.62.42.7-1.61.61.61.6-1.6-1.61.61.6-1.51.2
Bone: cortical porosity0.20.20.40.6-0.4-0.4-0.20.30.3-0.5-0.60.6-0.3
Bone: cortical porosity0.00.00.00.2-0.0-0.10.1-0.1-0.1-0.1-0.20.2-0.0
Bone: cortical thickness0.60.91.1-1.11.01.01.0-0.9-0.91.01.0-1.00.8
Bone: cortical thickness1.41.72.0-1.41.41.31.3-1.2-1.21.31.4-1.41.1
Bone: cortical tissue density0.20.20.40.5-0.5-0.5-0.60.50.5-0.4-0.50.2-0.4
Condit. Reinf. active minus inactive responses0.40.40.8-0.90.60.60.4-0.5-0.50.70.8-0.70.5
Condit. Reinf. active-inactive response ratio0.30.30.7-0.80.40.50.2-0.3-0.30.60.7-0.70.3
Condit. Reinf. active responses0.20.30.7-0.80.40.50.2-0.3-0.30.50.7-0.70.3
Condit. Reinf. inactive responses0.00.00.1-0.1-0.2-0.1-0.30.30.3-0.10.1-0.1-0.2
Incentive salience index mean0.20.20.5-0.70.50.50.3-0.4-0.40.50.7-0.60.4
Condit. Reinf. lever presses0.00.00.0-0.20.10.1-0.0-0.1-0.10.10.2-0.10.1
Condit. Reinf. active minus inactive responses0.10.10.2-0.40.30.30.2-0.2-0.20.30.4-0.40.2
Condit. Reinf. active-inactive response ratio0.40.50.7-0.90.60.70.5-0.6-0.60.80.8-0.80.5
Condit. Reinf. active responses0.10.10.20.3-0.2-0.3-0.30.40.4-0.3-0.30.3-0.3
Condit. Reinf. inactive responses0.70.91.11.0-0.9-0.9-0.81.01.0-1.0-1.01.0-0.8
Condit. Reinf. lever presses0.10.20.3-0.60.50.40.4-0.3-0.30.50.5-0.40.4
Condit. Reinf. lever reinforcers received0.10.10.20.4-0.3-0.3-0.30.40.4-0.3-0.40.4-0.3
Conditioned reinforcement - actives1.32.12.6-1.61.51.51.4-1.4-1.41.51.5-1.51.2
Conditioned reinforcement - inactives0.40.50.6-0.70.70.70.8-0.8-0.80.70.7-0.70.6
Conditioned locomotion2.32.93.4-1.81.81.71.7-1.7-1.71.81.8-1.71.4
Patch foraging indifference point 0 sec0.40.70.9-0.90.90.91.0-0.9-0.90.90.8-0.80.7
Patch foraging indifference point AUC2.94.25.0-1.92.22.12.2-2.2-2.22.01.9-2.01.8
Delay disc. indifference point, 0s delay1.31.51.81.3-1.2-1.2-1.11.21.2-1.2-1.31.3-1.0
Delay disc. indifference point, 16s delay1.21.41.71.3-1.1-1.1-1.11.21.2-1.1-1.21.2-0.9
Delay disc. indifference point, 2s delay3.84.25.72.4-1.9-2.0-1.72.12.1-2.1-2.22.4-1.6
Delay disc. indifference point, 24s delay0.00.10.1-0.30.20.20.10.00.00.30.3-0.30.2
Delay disc. indifference point, 4s delay0.00.00.00.20.0-0.00.10.10.1-0.1-0.10.20.0
Delay disc. indifference point, 8s delay1.72.02.51.6-1.4-1.4-1.31.41.4-1.4-1.51.6-1.2
Indifference point function ln k0.81.31.81.0-1.3-1.2-1.31.21.2-1.1-1.01.0-1.0
Indifference point function log k0.81.31.81.0-1.3-1.2-1.31.21.2-1.1-1.01.0-1.0
Patch foraging total patch changes 0 sec0.61.11.3-1.21.01.11.1-1.1-1.11.11.1-1.10.8
Patch foraging total patch changes 12 sec1.31.72.1-1.31.41.31.4-1.4-1.41.31.2-1.11.1
Patch foraging total patch changes 18 sec1.92.93.3-1.81.61.71.7-1.8-1.81.81.7-1.71.3
Patch foraging total patch changes 24 sec0.30.50.5-0.70.60.70.7-0.7-0.70.70.7-0.60.5
Patch foraging total patch changes 6 sec2.43.64.0-1.92.02.02.0-2.0-2.01.91.8-2.01.5
Patch foraging time to switch 0 sec2.65.36.72.6-2.3-2.4-2.22.22.2-2.4-2.52.4-1.9
Patch foraging water rate 0 sec2.86.06.9-2.62.42.52.5-2.4-2.42.52.5-2.62.0
Patch foraging water rate 12 sec0.10.30.5-0.70.40.50.3-0.4-0.40.60.6-0.70.3
Patch foraging water rate 18 sec0.10.20.3-0.50.30.50.4-0.3-0.30.50.5-0.60.3
Patch foraging water rate 24 sec0.50.81.0-1.00.90.90.9-0.8-0.80.91.0-1.00.7
Patch foraging water rate 6 sec0.71.01.6-1.10.91.00.8-0.8-0.81.11.1-1.30.8
Seeking ratio, delayed vs. immediate footshock1.82.22.61.6-1.6-1.5-1.61.51.5-1.5-1.51.4-1.3
Distance traveled before self-admin0.10.10.1-0.30.30.30.3-0.2-0.20.30.2-0.20.2
Distance traveled after self-admin0.10.20.20.4-0.4-0.4-0.40.50.5-0.4-0.40.4-0.3
Extensor digitorum longus weight1.76.98.1-2.92.52.62.6-2.7-2.72.62.8-2.52.1
Bone: elastic displacement1.01.21.71.0-1.3-1.1-1.21.01.0-1.1-0.91.0-1.0
Bone: elastic work0.00.00.1-0.20.00.10.1-0.1-0.10.10.2-0.20.0
Bone: endosteal estimation0.00.00.10.1-0.3-0.2-0.40.20.2-0.2-0.10.2-0.2
Bone: endosteal perimeter0.00.00.00.00.0-0.0-0.0-0.1-0.1-0.00.00.10.0
Epididymis fat weight0.20.81.21.1-0.8-0.9-0.80.80.8-0.9-1.01.0-0.7
Delta time in closed arm before/after self-admin0.10.10.10.3-0.3-0.3-0.30.40.4-0.2-0.20.2-0.1
Delta time in open arm before/after self-admin0.00.00.10.1-0.2-0.1-0.10.10.1-0.1-0.10.1-0.3
Diff in mean of infusions in LGA sessions1.31.61.81.3-1.3-1.3-1.31.21.2-1.3-1.31.2-1.1
Delay discount exponential model param1.41.52.0-1.41.11.21.1-1.3-1.31.21.3-1.40.9
Extinction: sum of active levers before priming0.00.00.10.1-0.3-0.2-0.20.10.1-0.3-0.10.1-0.2
Active lever presses in extinction session 60.10.10.1-0.30.20.20.2-0.4-0.40.20.3-0.40.1
Bone: final force0.40.60.7-0.80.80.80.8-0.8-0.80.80.8-0.70.7
Bone: final moment0.50.91.0-1.01.01.01.0-0.9-0.90.91.0-0.80.8
Food consumed during 24 hour testing period4.96.77.62.6-2.8-2.6-2.72.72.7-2.6-2.52.4-2.2
Glucose0.30.40.80.9-0.5-0.6-0.40.60.6-0.7-0.80.8-0.4
Heart weight2.23.43.7-1.91.91.91.9-1.9-1.91.81.8-1.81.5
Delay discount hyperbolic model param1.31.41.9-1.41.01.11.0-1.2-1.21.21.3-1.40.9
Intermittent access intake day 1-15 change0.10.10.2-0.40.40.40.5-0.3-0.30.40.4-0.40.3
Intermittent access intake escalation0.10.20.3-0.50.50.50.5-0.4-0.40.50.5-0.50.4
Intermittent access intake escalation 20.00.00.0-0.10.10.10.1-0.0-0.00.10.1-0.10.1
Intermitt. access day 1 inactive lever presses0.00.00.0-0.10.00.10.1-0.0-0.00.10.1-0.00.1
Intermitt. access day 15 inactive lever presses0.00.00.0-0.00.00.00.0-0.0-0.00.00.0-0.00.0
Intermitt. access escalation Index0.20.30.40.5-0.6-0.6-0.60.50.5-0.6-0.50.5-0.4
Intermittent access day 1 total infusions1.42.32.4-1.51.51.51.5-1.5-1.51.51.5-1.51.2
Intermittent access day 15 total infusions0.71.11.2-1.11.11.11.1-1.0-1.01.11.0-1.00.8
Intermittent access terminal intake (last 3 days)1.11.41.6-1.21.31.21.3-1.1-1.11.21.2-1.21.0
Intermittent access total infusions2.42.83.1-1.81.71.71.7-1.7-1.71.71.7-1.71.4
Intermittent access day 1 locomotion0.30.40.4-0.70.60.60.6-0.6-0.60.60.6-0.60.5
Intermittent access day 15 total locomotion0.10.20.3-0.50.50.50.5-0.5-0.50.50.5-0.50.4
Intermittent access total locomotion1.61.92.1-1.41.41.41.4-1.4-1.41.41.4-1.41.1
Intermittent access standard deviation0.10.20.30.5-0.4-0.4-0.40.50.5-0.5-0.50.5-0.3
Left kidney weight5.425.230.0-5.55.15.14.8-4.9-4.95.25.2-5.34.1
Right kidney weight5.022.826.7-5.24.84.94.7-4.7-4.74.94.9-4.93.9
Cocaine induced anxiety0.20.30.40.7-0.6-0.5-0.50.40.4-0.6-0.60.6-0.4
Post-drug Anxiety0.10.10.10.3-0.3-0.2-0.20.10.1-0.3-0.30.3-0.2
Baseline Anxiety0.00.00.0-0.10.00.00.0-0.0-0.00.00.1-0.00.0
Tail length0.31.21.4-1.01.21.11.2-1.2-1.21.11.0-1.10.8
Length with tail0.31.31.5-1.21.21.21.1-1.2-1.21.21.1-1.10.9
Length without tail0.31.11.8-1.31.01.10.9-1.0-1.01.11.2-1.00.8
Times rat made contact with spout0.00.00.1-0.2-0.2-0.1-0.30.20.20.00.1-0.2-0.1
Lifetime Intake2.32.83.0-1.71.71.71.7-1.7-1.71.71.7-1.71.4
Liver weight, left2.03.33.9-1.81.91.81.9-2.0-2.01.81.8-1.71.5
Liver weight, right1.22.12.7-1.61.41.51.3-1.4-1.41.51.5-1.61.1
Locomotor activity2.13.44.2-1.72.01.92.0-1.9-1.91.81.7-1.71.5
Locomotor testing distance1.12.12.6-1.31.51.51.6-1.6-1.61.41.3-1.41.1
Locomotor testing rearing4.18.49.1-2.93.03.03.0-3.0-3.02.92.8-2.82.3
Locomotion in novel chamber0.10.20.30.4-0.3-0.4-0.30.50.5-0.4-0.40.4-0.2
Locomotion in novel chamber post-restriction0.81.31.51.2-1.2-1.1-1.11.11.1-1.2-1.11.1-1.0
Fecal boli incidents, locomotor time 10.00.00.1-0.10.20.20.3-0.3-0.30.20.1-0.10.1
Change in fecal boli incidents, locomotor task0.80.81.11.0-0.9-0.9-0.80.90.9-0.9-1.01.1-0.8
Time >=10cm from walls, locomotor time 10.00.00.1-0.2-0.1-0.0-0.20.10.10.00.2-0.3-0.2
Bouts of movement, locomotor time 12.22.52.91.5-1.7-1.6-1.71.71.7-1.6-1.51.5-1.4
Total resting periods, locomotor time 13.03.33.71.8-1.9-1.8-1.91.91.9-1.8-1.81.7-1.6
Rest time, locomotor task time 10.10.20.20.4-0.5-0.4-0.50.40.4-0.4-0.40.3-0.4
Distance moved, locomotor task time 10.30.50.7-0.60.80.70.8-0.7-0.70.70.6-0.50.7
Vertical activity count, locomotor time 10.00.00.10.2-0.0-0.10.0-0.0-0.0-0.1-0.20.3-0.1
Time >=10cm from walls, locomotor time 20.10.10.20.4-0.2-0.3-0.20.20.2-0.3-0.40.4-0.2
Bouts of movement, locomotor time 24.36.98.12.6-2.7-2.7-2.82.82.8-2.6-2.52.5-2.1
Total resting periods, locomotor time 23.46.07.12.4-2.5-2.5-2.62.72.7-2.4-2.32.3-2.0
Rest time, locomotor task time 20.00.00.1-0.1-0.3-0.2-0.40.20.2-0.10.0-0.1-0.3
Distance moved, locomotor task time 20.70.81.2-0.71.00.91.1-0.9-0.90.90.7-0.60.9
Vertical activity count, locomotor time 20.10.10.40.6-0.2-0.3-0.10.20.2-0.4-0.50.6-0.1
Light reinforcement 10.10.10.4-0.40.20.40.2-0.4-0.40.40.4-0.60.2
Light reinforcement 20.10.10.2-0.30.30.30.2-0.4-0.40.30.3-0.50.2
Bone: marrow area0.00.00.10.1-0.2-0.2-0.30.10.1-0.2-0.00.1-0.1
Bone: maximum diameter2.24.24.8-2.22.12.12.0-2.1-2.12.02.1-2.01.7
Bone: maximum force0.20.30.4-0.60.60.60.6-0.5-0.50.50.5-0.50.5
Bone: maximum moment0.20.40.5-0.70.70.70.7-0.6-0.60.60.7-0.50.6
Mean time between licks in bursts0.00.10.10.4-0.3-0.3-0.30.30.3-0.3-0.40.3-0.3
Mean num. licks in bursts2.33.75.91.5-2.2-1.9-2.42.22.2-1.8-1.61.3-1.7
Cd content in liver0.00.10.2-0.1-0.3-0.2-0.40.30.3-0.10.00.1-0.1
Co content in liver1.31.51.81.3-1.2-1.2-1.21.21.2-1.2-1.31.4-1.0
Cu content in liver0.30.30.5-0.60.60.60.7-0.7-0.70.60.6-0.30.4
Fe content in liver4.65.67.2-2.12.62.52.7-2.5-2.52.42.1-2.12.0
K content in liver0.10.10.3-0.30.40.30.5-0.5-0.50.30.30.00.3
Mg content in liver0.50.50.8-0.60.80.70.9-0.8-0.80.70.6-0.40.6
Mn content in liver0.91.01.3-1.11.01.01.0-1.0-1.01.01.1-0.90.8
Na content in liver0.20.20.4-0.30.40.40.6-0.6-0.60.40.4-0.20.4
Rb content in liver0.10.10.4-0.60.20.30.1-0.3-0.30.40.5-0.40.2
Se content in liver3.54.15.6-1.72.22.12.4-2.2-2.22.01.7-1.81.7
Sr content in liver0.00.00.10.10.20.10.3-0.2-0.20.1-0.1-0.20.2
Zn content in liver0.80.81.1-1.00.90.90.9-1.0-1.00.91.0-0.70.7
Bone: minimum diameter0.20.30.4-0.60.50.60.6-0.6-0.60.60.6-0.50.4
Time in familiar zone, hab. session 10.20.20.3-0.40.50.40.5-0.5-0.50.40.4-0.30.4
Time in novel zone, hab. session 10.50.50.6-0.70.80.70.8-0.7-0.70.70.7-0.60.6
Total zone transitions, hab. session 10.20.30.5-0.60.40.50.3-0.4-0.40.50.6-0.70.3
Total locomotion distance, hab. session 10.40.60.70.8-0.7-0.7-0.70.80.8-0.7-0.80.7-0.6
Locomotion velocity, hab. session 11.21.72.01.4-1.3-1.3-1.31.41.4-1.3-1.41.3-1.1
Time in familiar zone, hab. session 20.20.20.4-0.30.50.50.6-0.6-0.60.40.3-0.30.4
Time in novel zone, hab. session 20.00.00.1-0.0-0.2-0.2-0.30.30.3-0.10.00.2-0.1
Total zone transitions, hab. session 20.50.60.8-0.70.80.80.9-0.9-0.90.80.7-0.70.7
Total locomotion distance, hab. session 20.60.71.01.0-0.8-0.9-0.80.80.8-0.9-0.91.0-0.7
Locomotion velocity, hab. session 20.30.50.60.8-0.7-0.7-0.60.70.7-0.7-0.80.7-0.5
Novel to familiar place preference ratio0.80.91.7-1.30.70.90.5-0.6-0.61.01.2-1.30.6
Novelty place preference0.70.81.5-1.20.70.90.5-0.6-0.60.91.1-1.20.6
Time in novel zone, NPP test0.90.91.7-1.30.80.90.6-0.7-0.71.01.2-1.20.7
Total zone transitions, NPP test0.10.20.2-0.30.40.40.5-0.4-0.40.40.3-0.40.3
Total locomotion distance, NPP test0.10.10.2-0.40.30.40.4-0.4-0.40.40.4-0.40.3
Locomotion velocity, NPP test0.10.10.1-0.30.30.30.3-0.3-0.30.40.3-0.40.3
Intraocular pressure0.00.00.0-0.0-0.1-0.1-0.10.10.1-0.00.00.20.1
Delta distance traveled before/after self-admin1.61.72.01.4-1.4-1.4-1.41.31.3-1.4-1.31.2-1.1
Delta ambulatory time before/after self-admin0.30.40.50.7-0.7-0.7-0.60.60.6-0.7-0.60.6-0.5
Parametrial fat weight0.10.10.2-0.40.40.30.3-0.3-0.30.30.4-0.40.4
Pavlov. Cond. lever latency0.50.60.91.0-0.7-0.8-0.60.70.7-0.8-0.90.8-0.6
Pavlov. Cond. magazine entry latency0.00.10.2-0.40.20.20.1-0.2-0.20.30.4-0.20.2
Pavlov. Cond. change in total contacts0.60.60.90.6-0.8-0.8-1.00.90.9-0.8-0.60.7-0.6
Pavlov. Cond. index score0.20.30.4-0.60.50.50.4-0.5-0.50.50.6-0.50.4
Pavlov. Cond. latency score0.00.00.1-0.30.20.20.1-0.2-0.20.20.3-0.10.2
Pavlov. Cond. lever contacts0.30.30.6-0.80.50.60.4-0.5-0.50.60.7-0.60.4
Pavlov. Cond. magazine entry number0.00.00.00.2-0.0-0.00.10.00.0-0.1-0.1-0.0-0.0
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.40.30.30.3-0.3-0.30.40.4-0.40.3
Pavlov. Cond. lever-magazine prob. diff.0.20.30.4-0.70.50.50.4-0.5-0.50.60.6-0.50.4
Pavlov. Cond. response bias0.70.91.5-1.20.90.90.7-0.9-0.91.01.1-1.00.7
Pavlov. Cond. lever latency0.00.00.00.2-0.2-0.1-0.20.10.1-0.1-0.20.0-0.1
Pavlov. Cond. magazine entry latency0.10.10.4-0.60.10.1-0.20.00.00.20.5-0.40.1
Pavlov. Cond. change in total contacts0.10.20.30.2-0.4-0.5-0.60.60.6-0.4-0.30.4-0.4
Pavlov. Cond. index score0.00.00.1-0.2-0.1-0.1-0.30.20.2-0.00.10.0-0.1
Pavlov. Cond. latency score0.00.10.1-0.0-0.3-0.2-0.40.30.3-0.2-0.00.2-0.2
Pavlov. Cond. lever contacts0.10.10.2-0.40.40.30.3-0.2-0.20.30.4-0.30.3
Pavlov. Cond. magazine entry number0.30.30.6-0.20.60.60.8-0.7-0.70.50.3-0.50.5
Pavlov. Cond. intertrial magazine entries0.00.00.00.20.10.10.2-0.1-0.10.0-0.1-0.10.1
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.40.10.1-0.10.10.10.10.3-0.2-0.0
Pavlov. Cond. response bias0.00.00.1-0.20.0-0.0-0.10.10.10.00.2-0.0-0.0
Time in closed arm before self-admin0.81.01.2-1.11.01.11.0-0.9-0.91.11.0-1.00.7
Time in closed arm after self-admin0.80.81.01.0-0.9-0.9-0.91.01.0-0.9-1.01.0-0.7
Time in open arm before self-admin0.80.91.11.1-1.0-1.0-1.00.80.8-1.0-1.01.0-0.6
Time in open arm after self-admin0.10.10.20.3-0.4-0.4-0.30.20.2-0.4-0.20.2-0.3
Bone: periosteal estimation0.30.60.7-0.80.70.70.7-0.8-0.80.80.8-0.70.6
Bone: periosteal perimeter0.20.40.5-0.70.70.70.7-0.7-0.70.70.7-0.60.5
Bone: post-yield work0.71.01.21.0-1.0-1.0-1.11.11.1-1.0-1.00.9-0.9
Progressive ratio test 1 active lever presses2.53.13.3-1.81.81.81.8-1.8-1.81.81.8-1.81.4
Progressive ratio test 1 breakpoint2.22.72.9-1.71.71.71.7-1.6-1.61.71.6-1.71.3
Progressive ratio test 1 inactive lever presses1.21.82.0-1.41.41.41.4-1.3-1.31.31.4-1.31.1
Progressive ratio test 2 active lever presses2.12.42.8-1.61.61.61.6-1.7-1.71.61.5-1.51.3
Progressive ratio test 2 breakpoint2.42.73.1-1.71.71.71.7-1.8-1.81.61.6-1.61.4
Progressive ratio test 2 inactive lever presses0.10.20.2-0.40.40.40.5-0.5-0.50.40.4-0.30.3
Incentive Sensitization - Responses1.01.51.7-1.21.21.21.2-1.3-1.31.21.2-1.11.0
Incentive Sensitization - Breakpoint1.01.31.5-1.21.11.11.2-1.2-1.21.11.1-1.10.9
Sum of active levers in priming session hrs 5-60.20.20.30.5-0.5-0.5-0.50.40.4-0.5-0.40.4-0.4
Progressive ratio1.11.72.11.4-1.4-1.3-1.31.21.2-1.4-1.41.2-1.1
Food seeking constrained by brief footshock5.06.26.72.5-2.6-2.5-2.62.52.5-2.5-2.52.5-2.1
Seeking ratio, punishment vs. effort0.50.70.90.7-0.8-0.8-1.00.90.9-0.8-0.80.8-0.7
Retroperitoneal fat weight0.00.10.2-0.30.40.30.3-0.4-0.40.30.3-0.30.4
Reaction time number correct3.87.38.1-2.82.72.82.8-2.7-2.72.82.7-2.72.2
Reaction time mean minus median0.00.10.10.1-0.3-0.3-0.40.40.4-0.2-0.10.2-0.2
Reaction time mean minus median AUC0.10.20.6-0.80.40.40.3-0.3-0.30.50.7-0.50.4
Reaction time num false alarms4.05.76.6-2.62.42.42.3-2.4-2.42.52.5-2.51.9
Reaction time num false alarms AUC3.14.85.5-2.32.22.22.2-2.3-2.32.22.2-2.21.8
Reaction time trials correct on left3.87.38.1-2.82.72.82.8-2.7-2.72.82.7-2.72.2
Reaction time trials on left3.97.38.1-2.82.72.82.8-2.7-2.72.82.7-2.72.2
Reaction time mean1.01.62.41.1-1.4-1.3-1.51.41.4-1.2-1.11.0-1.1
Reaction time mean AUC0.71.21.90.9-1.2-1.1-1.41.21.2-1.1-0.90.9-1.0
Median of all reaction times1.42.02.91.3-1.5-1.5-1.71.51.5-1.4-1.31.2-1.2
Reaction time omissions0.00.00.1-0.3-0.00.0-0.10.10.10.10.3-0.20.0
Reaction time false alarm rate0.10.10.1-0.40.40.30.3-0.4-0.40.40.4-0.40.3
Reaction time premature initiation rate0.40.60.80.6-0.9-0.8-0.90.80.8-0.7-0.60.6-0.6
Reaction time premature initiations0.20.40.8-0.90.50.70.5-0.6-0.60.70.8-0.70.5
Std. dev. reaction times0.10.20.30.3-0.5-0.5-0.60.60.6-0.5-0.30.5-0.4
Reaction time trials completed3.97.38.1-2.82.72.82.8-2.7-2.72.82.7-2.72.2
Reaction time trials AUC4.78.99.9-3.23.03.13.0-3.0-3.03.03.0-3.02.4
Run reversals in cocaine runway, females0.30.30.40.6-0.4-0.5-0.50.50.5-0.5-0.50.5-0.4
Run reversals in cocaine runway, males0.50.50.5-0.70.70.70.7-0.7-0.70.70.7-0.70.6
Latency to leave start box in cocaine runway0.10.10.3-0.40.40.40.2-0.1-0.10.40.4-0.60.1
Latency to leave start box in cocaine runway, F0.70.81.1-0.91.11.00.9-0.7-0.71.01.0-1.00.7
Latency to leave start box in cocaine runway, M0.10.10.30.1-0.4-0.3-0.50.40.4-0.3-0.20.1-0.3
Std. dev. time between licks in bursts0.00.00.1-0.2-0.00.1-0.10.10.10.20.2-0.4-0.1
Total sessions with >9 infusions3.74.54.8-2.12.22.22.2-2.2-2.22.12.1-2.11.7
Short access day 1 total inactive lever presses0.40.60.6-0.80.70.80.8-0.8-0.80.70.7-0.70.6
Short access day 10 total inactive lever presses0.61.41.61.2-1.2-1.2-1.21.21.2-1.2-1.21.2-0.9
Short access day 1 total infusions1.92.52.7-1.61.61.61.6-1.7-1.71.61.6-1.61.3
Short access day 10 total infusions3.54.54.9-2.22.22.22.1-2.1-2.12.12.1-2.11.7
Short access total infusions2.12.73.0-1.71.71.71.7-1.7-1.71.61.6-1.61.3
Short access day 1 locomotion3.13.94.1-2.02.02.02.0-2.0-2.02.01.9-2.01.6
Short access day 10 total locomotion0.00.00.0-0.20.10.10.1-0.0-0.00.10.2-0.10.1
Short access total locomotion0.70.91.0-1.01.01.00.9-0.9-0.91.01.0-1.00.8
One hour access (0.3 mA shock)0.00.00.1-0.20.20.20.2-0.1-0.10.20.2-0.20.2
Compulsive drug intake0.20.30.4-0.70.60.60.5-0.4-0.40.60.6-0.60.4
One hour access (shock baseline)0.81.21.4-1.11.11.11.2-1.1-1.11.11.1-1.10.9
Social response proportion1.11.32.1-1.41.01.10.8-1.0-1.01.21.3-1.40.8
Social responses0.91.11.4-1.21.11.00.9-1.0-1.01.11.1-1.20.9
Social time3.24.35.12.1-2.1-2.1-2.12.32.3-2.1-2.02.0-1.7
Soleus weight0.10.40.6-0.80.50.60.5-0.6-0.60.60.8-0.70.4
Bone: stiffness0.81.31.6-1.11.21.21.3-1.2-1.21.11.0-0.91.0
Tibialis anterior weight3.311.213.5-3.73.23.43.2-3.4-3.43.43.5-3.52.7
Time to tail flick, vehicle, before self-admin2.93.03.4-1.71.81.81.8-1.8-1.81.71.7-1.81.4
Time to tail flick, vehicle, after self-admin0.00.00.0-0.10.20.10.1-0.1-0.10.10.0-0.00.1
Time to tail flick, test, before self-admin0.40.40.50.6-0.7-0.7-0.70.60.6-0.7-0.60.6-0.6
Time to tail flick, test, after self-admin0.20.20.40.6-0.4-0.5-0.40.40.4-0.5-0.60.6-0.3
Delta time to tail flick, vehicle, before/after SA0.10.10.20.3-0.3-0.3-0.30.40.4-0.3-0.30.4-0.2
Delta time to tail flick, test, before/after SA0.70.80.9-0.81.00.91.0-0.8-0.80.90.8-0.80.8
Tibia length0.20.50.7-0.80.80.80.7-0.6-0.60.80.8-0.70.6
Ambulatory time before self-admin0.00.00.00.0-0.0-0.0-0.10.10.1-0.0-0.10.1-0.1
Ambulatory time after self-admin0.40.50.50.7-0.7-0.7-0.70.70.7-0.7-0.70.6-0.6
Bone: tissue strength0.80.81.10.8-0.9-0.9-1.01.01.0-0.9-0.80.9-0.7
Total heroin consumption0.00.00.00.1-0.1-0.1-0.10.10.1-0.1-0.10.1-0.1
Bone: trabecular number0.10.10.30.0-0.3-0.3-0.50.40.4-0.2-0.1-0.0-0.3
Bone: trabecular spacing0.10.10.1-0.20.20.20.3-0.4-0.40.20.30.10.3
Bone: trabecular thickness1.31.72.3-1.51.31.31.2-1.1-1.11.41.4-1.51.0
Bone: trabecular tissue density0.30.40.6-0.60.70.70.7-0.6-0.60.70.6-0.70.6
Water consumed over 24 hours0.10.20.40.2-0.5-0.4-0.70.50.5-0.3-0.20.1-0.4
Number of responses in last shaping day2.93.23.5-1.81.91.81.8-1.9-1.91.81.8-1.81.5