Hub : Genes

Kdm3b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	gene expression	Kdm3b	0.23	0.16	8.0e-03	0.08	0.06	0.03	0.05	5.5e-03	1.7e-02	5.5e-02	2.1e-02
2	NAcc	intron excision ratio	chr18_26689613_26690444	0.02	0.01	9.4e-03	0.02	0	0.01	0.01	1.4e-03	7.7e-02	1.3e-02	6.8e-03
3	PL	gene expression	Kdm3b	0.02	0.02	6.9e-03	0.02	0.01	0.01	0.01	6.4e-03	2.1e-02	7.9e-03	1.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	2.1	3.6	5.8	0.2	2.4	-2.2
Area under the delay curve	2.2	2.6	5.1	2.3	1.3	-1.0
BMI with tail	4.2	14.5	24.8	-5.0	-3.2	2.9
BMI without tail	3.7	11.3	23.3	-4.8	-2.5	2.1
Body weight	3.5	15.5	33.2	-5.8	-2.9	2.2
Weight adjusted by age	1.6	2.4	4.6	-2.1	-0.8	1.4
Bone surface	1.9	3.5	5.0	0.7	2.2	-2.2
Bone volume	1.8	3.2	4.7	0.4	2.1	-2.2
Breakpoint value in progressive ratio session	0.3	0.3	0.7	0.8	0.3	-0.5
Number of licking bursts	0.2	0.3	0.6	0.8	0.3	-0.3
Context. condit. distance diff. score	0.1	0.1	0.2	-0.4	-0.4	0.2
Locomotion velocity, session 1	0.1	0.2	0.2	-0.4	0.3	-0.4
Locomotion distance, session 1	0.1	0.1	0.2	-0.1	-0.5	0.2
Locomotion velocity, session 2	1.2	1.4	2.2	-0.4	-1.4	1.5
Locomotion distance, session 2	0.2	0.3	0.7	0.8	0.2	-0.2
Locomotion velocity, session 3	0.3	0.3	0.7	-0.4	-0.9	0.0
Locomotion distance, session 3	0.4	0.5	1.0	0.3	0.5	-1.0
Stereotopy head waving bouts, day 3	0.9	1.1	2.6	1.6	0.4	-0.6
Stereotopy head waving duration, day 3	0.4	0.5	0.6	0.7	-0.5	0.8
Locomotion velocity, session 7	0.7	0.8	1.1	-0.7	0.8	-1.1
Locomotion distance, session 7	1.7	2.1	3.2	0.1	1.8	-1.8
Stereotopy head waving bouts, day 7	1.0	1.2	2.2	-0.3	-1.1	1.5
Stereotopy head waving duration, day 7	2.0	2.4	4.4	-0.1	-1.7	2.1
Locomotion velocity, session 8	2.5	3.0	4.6	0.0	-2.1	2.1
Locomotion distance, session 8	0.1	0.2	0.5	-0.2	-0.7	0.1
Degree of sensitization distance	0.2	0.2	0.5	-0.7	0.4	0.1
Degree of sensitization stereotypy	1.8	1.9	3.4	-0.1	-1.5	1.9
Conditioned locomotion	0.6	0.6	1.2	-0.1	0.8	-1.1
Cocaine response after cond. corrected	0.5	0.6	1.5	-1.2	-0.3	-0.4
Cocaine response after cond. not corrected	0.2	0.3	0.5	-0.6	-0.7	0.2
Cocaine response before conditioning	1.7	2.0	4.4	2.1	-0.7	1.1
Saline control response	0.3	0.4	0.6	0.8	-0.7	0.4
Bone: connectivity density	2.7	4.2	5.4	1.5	2.3	-2.2
Bone: cortical apparent density	0.4	0.5	1.1	1.0	-0.6	0.2
Bone: cortical area	1.2	1.9	2.7	1.2	1.3	-1.6
Bone: cortical porosity	0.7	0.8	1.9	-1.4	-0.5	0.4
Bone: cortical porosity	0.5	0.6	1.6	-1.3	-0.2	0.2
Bone: cortical thickness	0.7	1.2	1.8	1.4	0.7	-1.1
Bone: cortical thickness	0.2	0.3	0.4	0.3	0.5	-0.6
Bone: cortical tissue density	0.3	0.5	1.0	1.0	-0.6	0.2
Condit. Reinf. active minus inactive responses	1.5	1.7	2.8	1.7	0.9	-1.1
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.2	1.1	0.4	-0.5
Condit. Reinf. active responses	2.1	2.6	3.6	1.3	1.5	-1.9
Condit. Reinf. inactive responses	2.1	2.6	4.5	0.7	1.7	-2.1
Incentive salience index mean	1.0	1.2	2.1	1.4	0.8	-1.0
Condit. Reinf. lever presses	0.4	0.6	0.6	0.7	0.8	-0.7
Condit. Reinf. active minus inactive responses	1.7	2.1	3.8	1.9	1.0	-1.2
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.0	-0.1	0.8	-1.0
Condit. Reinf. active responses	3.0	4.2	10.0	3.2	1.1	-1.2
Condit. Reinf. inactive responses	2.6	3.4	9.7	3.1	0.5	-0.3
Condit. Reinf. lever presses	1.9	2.7	2.7	1.6	1.7	-1.6
Condit. Reinf. lever reinforcers received	2.7	3.8	9.7	3.1	0.9	-0.9
Conditioned reinforcement - actives	0.3	0.5	1.0	-0.3	-0.7	1.0
Conditioned reinforcement - inactives	0.1	0.1	0.4	0.6	-0.1	0.1
Conditioned locomotion	0.2	0.2	0.3	-0.3	-0.6	0.4
Patch foraging indifference point 0 sec	0.4	0.7	1.7	1.3	-0.3	0.4
Patch foraging indifference point AUC	3.4	4.9	7.2	2.7	2.2	-1.6
Delay disc. indifference point, 0s delay	1.0	1.0	1.9	1.4	1.0	-0.6
Delay disc. indifference point, 16s delay	2.1	2.4	5.3	2.3	1.0	-0.9
Delay disc. indifference point, 2s delay	1.1	1.2	1.5	1.0	1.2	-1.0
Delay disc. indifference point, 24s delay	0.8	1.0	1.1	0.9	1.0	-1.1
Delay disc. indifference point, 4s delay	1.4	1.5	2.3	1.0	1.5	-1.1
Delay disc. indifference point, 8s delay	2.5	3.0	6.1	2.5	1.2	-1.1
Indifference point function ln k	6.5	11.4	16.9	-4.1	-3.3	2.5
Indifference point function log k	6.5	11.4	16.9	-4.1	-3.3	2.5
Patch foraging total patch changes 0 sec	0.3	0.6	1.7	1.3	-0.2	0.2
Patch foraging total patch changes 12 sec	4.8	6.2	15.0	3.9	1.7	-0.9
Patch foraging total patch changes 18 sec	5.8	8.9	10.6	2.7	3.3	-3.0
Patch foraging total patch changes 24 sec	1.2	2.0	3.1	1.8	1.3	-1.1
Patch foraging total patch changes 6 sec	2.1	3.2	5.6	2.4	1.7	-1.1
Patch foraging time to switch 0 sec	0.0	0.1	0.2	-0.5	0.0	0.2
Patch foraging water rate 0 sec	0.0	0.0	0.0	-0.0	0.0	0.0
Patch foraging water rate 12 sec	0.4	0.8	2.2	-1.5	0.4	-0.3
Patch foraging water rate 18 sec	0.2	0.3	0.4	-0.6	-0.5	0.6
Patch foraging water rate 24 sec	0.1	0.1	0.3	-0.6	0.2	-0.3
Patch foraging water rate 6 sec	0.2	0.4	0.8	-0.4	0.4	-0.9
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.5	0.7	0.1	0.3
Distance traveled before self-admin	2.2	2.9	4.4	0.4	2.0	-2.1
Distance traveled after self-admin	2.1	2.6	4.1	1.2	1.5	-2.0
Extensor digitorum longus weight	1.6	6.3	12.1	-3.5	-1.8	1.9
Bone: elastic displacement	1.2	1.3	1.4	-1.1	-1.2	1.2
Bone: elastic work	2.3	3.0	3.7	-1.5	-1.7	1.9
Bone: endosteal estimation	0.1	0.3	0.7	0.2	0.8	-0.5
Bone: endosteal perimeter	0.0	0.0	0.0	-0.1	-0.2	-0.2
Epididymis fat weight	2.2	7.4	8.8	-3.0	-2.7	2.4
Delta time in closed arm before/after self-admin	2.7	2.5	3.8	-1.0	-2.0	1.6
Delta time in open arm before/after self-admin	1.1	1.1	1.6	0.3	1.3	-1.2
Diff in mean of infusions in LGA sessions	0.1	0.1	0.1	-0.4	-0.3	-0.1
Delay discount exponential model param	2.5	2.8	4.8	-2.2	-1.4	1.2
Extinction: sum of active levers before priming	0.9	1.0	2.1	-0.2	0.9	-1.4
Active lever presses in extinction session 6	1.2	1.2	1.8	1.3	0.7	-1.1
Bone: final force	0.3	0.5	0.9	0.4	0.7	-1.0
Bone: final moment	0.2	0.3	0.5	-0.1	0.6	-0.7
Food consumed during 24 hour testing period	0.7	1.0	1.2	-0.8	1.1	-1.0
Glucose	2.3	3.6	10.6	-3.2	-0.2	0.5
Heart weight	1.3	2.0	4.0	-2.0	-0.8	1.1
Delay discount hyperbolic model param	2.8	3.1	4.8	-2.2	-1.6	1.4
Intermittent access intake day 1-15 change	1.3	2.6	5.1	-0.3	-2.3	1.6
Intermittent access intake escalation	1.4	2.8	5.5	-0.4	-2.3	1.7
Intermittent access intake escalation 2	1.7	1.9	3.7	-0.5	-1.9	1.3
Intermitt. access day 1 inactive lever presses	0.1	0.3	0.9	0.9	0.1	-0.2
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.5	-0.0	-0.6	0.7
Intermitt. access escalation Index	0.1	0.2	0.4	-0.6	-0.5	-0.1
Intermittent access day 1 total infusions	0.3	0.5	0.7	0.6	-0.6	0.8
Intermittent access day 15 total infusions	2.0	3.0	4.9	0.2	-2.2	2.0
Intermittent access terminal intake (last 3 days)	3.2	4.2	6.7	0.2	-2.6	2.4
Intermittent access total infusions	1.6	1.9	3.1	-0.3	-1.6	1.8
Intermittent access day 1 locomotion	0.3	0.4	0.8	0.3	-0.6	0.9
Intermittent access day 15 total locomotion	1.4	2.6	3.0	-1.3	-1.7	1.7
Intermittent access total locomotion	1.5	1.9	2.8	-0.7	-1.5	1.7
Intermittent access standard deviation	1.2	2.6	3.9	0.0	-2.0	2.0
Left kidney weight	0.3	1.3	3.8	-1.9	0.1	-0.1
Right kidney weight	0.1	0.4	1.0	-1.0	0.0	0.1
Cocaine induced anxiety	0.8	1.1	2.0	-0.6	1.4	-1.0
Post-drug Anxiety	0.8	0.8	1.2	-1.1	0.9	-0.7
Baseline Anxiety	1.2	1.4	2.1	-0.9	-1.5	1.0
Tail length	0.2	0.7	1.8	-1.3	0.1	-0.4
Length with tail	0.4	1.7	4.7	-2.2	-0.6	0.0
Length without tail	0.2	0.6	1.5	-1.2	-0.5	0.3
Times rat made contact with spout	2.0	2.3	3.7	-0.3	1.7	-1.9
Lifetime Intake	2.3	2.8	4.4	-0.5	-1.9	2.1
Liver weight, left	0.2	0.4	1.0	1.0	-0.0	0.5
Liver weight, right	1.3	2.2	5.5	2.3	-0.8	0.7
Locomotor activity	0.3	0.5	0.6	0.8	0.7	-0.7
Locomotor testing distance	0.4	0.7	1.1	0.4	0.9	-1.1
Locomotor testing rearing	0.3	0.5	1.1	1.1	0.6	-0.3
Locomotion in novel chamber	1.0	1.3	2.8	-0.1	-1.1	1.7
Locomotion in novel chamber post-restriction	0.7	1.2	2.1	-0.6	-1.0	1.4
Fecal boli incidents, locomotor time 1	0.3	0.5	1.1	-0.3	-0.5	1.1
Change in fecal boli incidents, locomotor task	0.3	0.3	0.8	-0.0	-0.9	0.5
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.3	-0.4	0.2	-0.5
Bouts of movement, locomotor time 1	0.3	0.4	1.0	1.0	0.3	-0.3
Total resting periods, locomotor time 1	0.2	0.3	0.8	0.9	0.1	0.0
Rest time, locomotor task time 1	0.4	0.5	1.1	-0.3	-1.0	0.6
Distance moved, locomotor task time 1	0.5	0.8	1.2	0.1	1.0	-1.1
Vertical activity count, locomotor time 1	0.6	1.4	2.1	-0.5	1.4	-1.4
Time >=10cm from walls, locomotor time 2	1.4	2.0	5.6	-2.4	0.6	-0.3
Bouts of movement, locomotor time 2	0.2	0.3	0.6	0.5	-0.8	0.4
Total resting periods, locomotor time 2	0.1	0.2	0.6	0.2	-0.8	0.3
Rest time, locomotor task time 2	0.5	0.6	1.2	-1.1	-0.8	0.3
Distance moved, locomotor task time 2	0.6	0.7	1.1	0.1	1.1	-1.0
Vertical activity count, locomotor time 2	2.0	2.7	5.3	0.4	2.3	-1.7
Light reinforcement 1	0.4	1.0	1.7	1.3	0.7	-1.0
Light reinforcement 2	2.7	4.1	4.9	2.2	2.1	-1.7
Bone: marrow area	0.1	0.3	0.5	0.2	0.7	-0.4
Bone: maximum diameter	0.9	1.8	2.3	1.3	1.1	-1.5
Bone: maximum force	0.1	0.2	0.4	-0.4	0.4	-0.6
Bone: maximum moment	0.2	0.3	0.7	-0.8	0.2	-0.4
Mean time between licks in bursts	0.2	0.5	1.4	-1.2	-0.0	-0.2
Mean num. licks in bursts	0.3	0.5	1.0	-1.0	0.5	-0.5
Cd content in liver	0.7	0.8	1.0	1.0	0.8	-0.8
Co content in liver	1.3	1.5	2.3	-0.7	1.3	-1.5
Cu content in liver	1.9	2.3	4.4	2.1	1.3	-0.9
Fe content in liver	4.7	5.7	9.6	0.9	3.1	-2.6
K content in liver	1.0	1.0	1.4	1.2	-0.6	1.1
Mg content in liver	0.9	0.9	2.3	1.5	-0.4	0.6
Mn content in liver	0.5	0.6	0.9	-0.5	-1.0	0.7
Na content in liver	1.4	1.4	2.1	0.4	1.4	-1.4
Rb content in liver	0.9	1.1	1.4	0.7	-1.2	1.2
Se content in liver	0.2	0.2	0.5	0.4	0.7	-0.3
Sr content in liver	1.5	1.3	1.7	0.9	1.2	-1.3
Zn content in liver	3.2	3.5	9.9	3.1	0.7	-0.5
Bone: minimum diameter	0.8	1.5	2.4	0.4	1.5	-1.4
Time in familiar zone, hab. session 1	0.4	0.4	0.7	-0.8	0.3	-0.7
Time in novel zone, hab. session 1	0.5	0.5	1.5	1.2	0.2	0.3
Total zone transitions, hab. session 1	0.8	1.1	1.7	-1.3	0.8	-1.0
Total locomotion distance, hab. session 1	1.6	2.3	3.6	0.6	1.7	-1.9
Locomotion velocity, hab. session 1	1.3	1.8	3.3	0.5	1.4	-1.8
Time in familiar zone, hab. session 2	1.6	1.7	3.9	2.0	0.6	-0.8
Time in novel zone, hab. session 2	1.0	1.0	2.8	-1.7	-0.1	0.3
Total zone transitions, hab. session 2	0.2	0.2	0.5	-0.4	-0.7	0.2
Total locomotion distance, hab. session 2	0.3	0.3	0.8	0.4	0.1	-0.9
Locomotion velocity, hab. session 2	0.3	0.4	1.0	0.2	0.2	-1.0
Novel to familiar place preference ratio	0.5	0.6	1.6	-1.2	-0.3	0.3
Novelty place preference	0.7	0.7	1.7	-1.3	-0.5	0.5
Time in novel zone, NPP test	0.7	0.7	1.6	-1.3	-0.5	0.5
Total zone transitions, NPP test	0.1	0.1	0.2	-0.3	0.0	-0.5
Total locomotion distance, NPP test	1.0	1.4	2.5	0.6	1.1	-1.6
Locomotion velocity, NPP test	1.0	1.5	2.6	0.7	1.2	-1.6
Intraocular pressure	2.5	3.6	6.3	-2.5	-1.8	1.1
Delta distance traveled before/after self-admin	0.7	0.8	1.8	1.3	0.2	-0.7
Delta ambulatory time before/after self-admin	1.4	1.7	2.3	1.3	1.1	-1.5
Parametrial fat weight	0.7	1.7	2.1	-1.1	-1.4	1.5
Pavlov. Cond. lever latency	0.1	0.1	0.1	0.2	0.3	-0.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.0	-0.4	0.5
Pavlov. Cond. change in total contacts	0.7	0.7	1.3	0.0	1.1	-1.0
Pavlov. Cond. index score	0.0	0.0	0.1	-0.2	0.1	-0.0
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.4	-0.1	0.2
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.0	-0.2	0.5
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.0	-0.1	0.3
Pavlov. Cond. intertrial magazine entries	1.8	2.2	4.0	0.7	1.5	-2.0
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.1	0.3	-0.1
Pavlov. Cond. response bias	0.0	0.0	0.0	-0.0	0.2	-0.2
Pavlov. Cond. lever latency	0.9	1.3	1.5	-1.2	-1.1	1.0
Pavlov. Cond. magazine entry latency	0.3	0.4	0.5	0.3	0.7	-0.7
Pavlov. Cond. change in total contacts	1.1	1.8	3.2	1.8	1.0	-1.2
Pavlov. Cond. index score	0.8	1.1	1.4	1.2	0.9	-1.0
Pavlov. Cond. latency score	0.6	0.8	1.2	1.1	0.8	-0.7
Pavlov. Cond. lever contacts	0.9	1.3	1.4	1.2	1.0	-1.2
Pavlov. Cond. magazine entry number	0.4	0.4	1.3	-1.1	-0.1	0.0
Pavlov. Cond. intertrial magazine entries	1.2	1.8	3.2	0.1	1.5	-1.8
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.1	1.3	1.2	0.9	-1.0
Pavlov. Cond. response bias	1.4	1.9	2.5	1.6	1.3	-1.3
Time in closed arm before self-admin	1.0	1.2	2.8	-1.7	0.7	-0.6
Time in closed arm after self-admin	0.4	0.4	1.3	-1.1	0.0	-0.2
Time in open arm before self-admin	1.3	1.4	1.8	1.3	-1.3	0.9
Time in open arm after self-admin	0.1	0.1	0.2	0.4	-0.1	-0.1
Bone: periosteal estimation	0.4	0.9	1.2	0.5	1.1	-1.1
Bone: periosteal perimeter	0.0	0.1	0.1	0.3	-0.2	-0.3
Bone: post-yield work	0.0	0.1	0.1	-0.3	0.1	-0.3
Progressive ratio test 1 active lever presses	0.8	0.9	1.7	-0.4	-0.9	1.3
Progressive ratio test 1 breakpoint	0.9	1.1	2.0	-0.4	-1.1	1.4
Progressive ratio test 1 inactive lever presses	0.8	1.1	2.1	0.2	-1.1	1.4
Progressive ratio test 2 active lever presses	0.9	1.1	1.6	-0.5	-1.1	1.3
Progressive ratio test 2 breakpoint	0.7	0.8	1.3	-0.5	-1.0	1.1
Progressive ratio test 2 inactive lever presses	0.6	0.9	1.5	-0.3	-1.2	1.1
Incentive Sensitization - Responses	0.0	0.1	0.1	-0.3	0.2	-0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.3	0.4	-0.3
Sum of active levers in priming session hrs 5-6	7.4	6.9	7.5	2.7	2.4	-2.7
Progressive ratio	0.1	0.2	0.2	0.5	-0.3	0.4
Food seeking constrained by brief footshock	0.2	0.2	0.5	0.7	0.2	-0.2
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	-0.1	-0.3	0.2
Retroperitoneal fat weight	1.3	5.4	7.5	-2.7	-2.1	2.1
Reaction time number correct	0.4	0.8	2.4	-1.5	-0.0	-0.0
Reaction time mean minus median	0.7	1.8	2.8	0.3	1.6	-1.7
Reaction time mean minus median AUC	1.3	3.3	4.9	-0.2	2.2	-2.2
Reaction time num false alarms	0.1	0.2	0.4	-0.6	0.1	0.3
Reaction time num false alarms AUC	0.4	0.6	0.9	-1.0	-0.3	0.9
Reaction time trials correct on left	0.4	0.8	2.4	-1.5	-0.0	-0.0
Reaction time trials on left	0.4	0.8	2.4	-1.5	-0.0	-0.0
Reaction time mean	0.1	0.1	0.2	-0.4	0.2	0.1
Reaction time mean AUC	0.0	0.0	0.0	-0.2	0.2	-0.1
Median of all reaction times	0.4	0.5	0.8	-0.7	-0.5	0.9
Reaction time omissions	0.0	0.0	0.0	-0.1	-0.1	0.0
Reaction time false alarm rate	0.1	0.1	0.3	-0.2	-0.1	0.6
Reaction time premature initiation rate	1.0	1.4	2.0	0.8	1.4	-1.3
Reaction time premature initiations	0.4	0.8	1.3	0.3	1.1	-1.0
Std. dev. reaction times	1.6	2.9	4.3	-0.4	2.1	-2.1
Reaction time trials completed	0.4	0.8	2.4	-1.5	-0.0	-0.0
Reaction time trials AUC	0.4	0.8	2.3	-1.5	0.1	-0.1
Run reversals in cocaine runway, females	0.2	0.2	0.3	0.5	-0.2	0.4
Run reversals in cocaine runway, males	1.2	1.2	2.6	0.2	-1.0	1.6
Latency to leave start box in cocaine runway	0.7	0.8	1.7	1.3	0.2	-0.8
Latency to leave start box in cocaine runway, F	0.3	0.4	0.8	0.9	-0.2	-0.6
Latency to leave start box in cocaine runway, M	0.3	0.2	0.7	0.8	0.1	-0.2
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.1	0.4	-0.4
Total sessions with >9 infusions	2.8	3.4	4.4	-1.3	-2.0	2.1
Short access day 1 total inactive lever presses	0.5	0.6	0.8	0.7	0.9	-0.8
Short access day 10 total inactive lever presses	0.3	0.8	1.3	0.5	0.9	-1.1
Short access day 1 total infusions	1.2	1.6	2.6	-0.0	-1.5	1.6
Short access day 10 total infusions	0.2	0.2	0.4	-0.0	-0.6	0.5
Short access total infusions	1.6	2.1	3.2	-0.1	-1.8	1.8
Short access day 1 locomotion	0.8	1.0	1.9	-1.4	-1.0	0.4
Short access day 10 total locomotion	1.6	2.9	3.2	-1.7	-1.8	1.6
Short access total locomotion	1.5	1.8	2.5	-0.9	-1.6	1.4
One hour access (0.3 mA shock)	1.1	1.3	1.9	-0.1	-1.4	1.4
Compulsive drug intake	0.4	0.5	0.8	-0.9	0.6	-0.6
One hour access (shock baseline)	1.1	1.7	2.5	0.4	-1.6	1.6
Social response proportion	2.6	2.9	5.2	-0.3	-2.3	1.9
Social responses	0.5	0.7	2.0	1.4	-0.2	0.1
Social time	5.1	6.9	10.6	0.1	-3.2	3.2
Soleus weight	3.7	10.8	14.2	-2.5	-3.5	3.8
Bone: stiffness	0.2	0.4	0.6	0.2	0.7	-0.8
Tibialis anterior weight	1.5	5.2	6.8	-2.6	-2.4	1.7
Time to tail flick, vehicle, before self-admin	1.9	2.0	2.2	1.3	1.5	-1.4
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.4	0.6	0.3	-0.4
Time to tail flick, test, before self-admin	0.6	0.6	0.9	-0.7	0.9	-0.7
Time to tail flick, test, after self-admin	0.7	0.8	1.2	0.8	-0.6	1.1
Delta time to tail flick, vehicle, before/after SA	3.1	2.9	4.8	-0.6	-2.2	1.9
Delta time to tail flick, test, before/after SA	2.7	2.8	4.8	0.5	-1.8	2.2
Tibia length	0.2	0.7	1.3	-1.1	0.4	-0.8
Ambulatory time before self-admin	1.3	1.9	3.0	0.2	1.6	-1.7
Ambulatory time after self-admin	3.0	3.5	5.5	1.2	1.9	-2.3
Bone: tissue strength	0.2	0.2	0.5	-0.2	0.1	-0.7
Total heroin consumption	0.0	0.0	0.1	0.3	-0.0	-0.2
Bone: trabecular number	1.5	2.5	3.8	0.1	1.9	-1.9
Bone: trabecular spacing	1.9	2.5	4.2	0.1	-2.1	1.8
Bone: trabecular thickness	0.7	0.9	1.7	0.5	1.3	-0.9
Bone: trabecular tissue density	0.9	1.3	2.7	-0.5	-1.6	1.0
Water consumed over 24 hours	5.2	6.9	11.8	0.4	3.0	-3.4
Number of responses in last shaping day	0.6	0.7	1.3	1.2	-0.5	0.7