Kctd21

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative TSS	XM_039087670.2	0.09	0.05	2.1e-08	0.06	0.05	0.04	0.05	9.2e-07	2.0e-06	1.8e-05	7.6e-06
2	Adipose	alternative TSS	XM_006229781.5	0.08	0.05	4.6e-08	0.05	0.05	0.04	0.04	1.4e-06	4.9e-06	3.7e-05	2.1e-05
3	Adipose	isoform ratio	XM_039087670.2	0.04	0.03	2.5e-04	0.02	0.02	0.01	0.01	1.1e-03	4.7e-03	1.0e-02	9.4e-03
4	Adipose	mRNA stability	Kctd21	0.08	0.05	7.2e-07	0.05	0.04	0.04	0.04	7.4e-06	1.2e-05	3.6e-05	1.2e-05
5	Adipose	isoform ratio	XM_006229781.5	0.05	0.03	8.9e-05	0.03	0.02	0.01	0.01	5.2e-04	2.2e-03	1.1e-02	1.8e-02
6	Adipose	alternative TSS	XM_039087670.2	0.04	0.03	2.4e-04	0.01	0.02	0.01	0.01	1.8e-02	5.1e-03	1.3e-02	1.7e-02
7	Adipose	gene expression	Kctd21	0.05	0.03	9.5e-06	0.02	0.03	0.03	0.03	1.1e-03	1.7e-04	5.8e-04	6.0e-04
8	Brain	gene expression	Kctd21	0.03	0.02	5.7e-03	0.03	0.01	0.01	0.02	8.6e-04	1.5e-02	3.8e-02	4.2e-03
9	IC	gene expression	Kctd21	0.11	0.07	4.0e-03	0.05	0.02	0.02	0.03	3.1e-03	5.6e-02	5.0e-02	3.1e-02
10	NAcc	gene expression	Kctd21	0.05	0.03	1.9e-07	0.06	0.05	0.04	0.06	7.0e-09	4.5e-08	2.0e-07	1.0e-08
11	PL	gene expression	Kctd21	0.09	0.04	1.3e-08	0.08	0.08	0.07	0.08	1.1e-08	1.0e-08	1.6e-08	1.2e-08
12	BLA	gene expression	Kctd21	0.06	0.04	1.0e-02	0.01	0.03	0.03	0.02	5.3e-02	1.7e-02	6.8e-03	4.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12
Bone: apparent density	0.1	0.2	0.4	-0.1	0.1	-0.1	0.1	-0.3	-0.4	0.6	0.6	0.6	0.5	0.6	0.5
Area under the delay curve	0.5	0.6	1.4	-1.2	1.2	-1.2	1.2	0.9	-0.8	-0.2	0.3	0.3	0.2	0.4	0.4
BMI with tail	2.5	8.7	12.7	3.1	-3.1	3.1	-3.1	-0.4	3.6	-2.1	-3.2	-3.2	-3.0	-3.0	-3.3
BMI without tail	4.1	12.5	17.5	3.6	-3.6	3.6	-3.6	-0.3	4.2	-2.8	-3.9	-3.8	-3.6	-3.6	-4.1
Body weight	3.4	14.9	23.2	4.1	-4.1	4.1	-4.1	-0.6	4.8	-2.7	-3.9	-3.9	-3.8	-3.8	-4.5
Weight adjusted by age	0.5	0.8	1.6	0.6	-0.6	0.6	-0.6	0.6	0.6	-1.0	-1.2	-1.2	-1.3	-1.2	-0.6
Bone surface	0.5	0.9	3.1	-1.1	1.1	-1.1	1.1	1.8	-0.8	-0.9	-0.5	-0.5	-0.5	-0.4	0.4
Bone volume	0.3	0.5	1.7	-0.5	0.5	-0.5	0.5	1.3	-0.2	-1.0	-0.8	-0.7	-0.7	-0.6	-0.1
Breakpoint value in progressive ratio session	0.5	0.6	1.3	-0.3	0.3	-0.3	0.3	-0.6	-0.6	1.1	1.0	1.0	0.9	1.1	0.7
Number of licking bursts	0.8	1.4	3.1	1.7	-1.7	1.7	-1.7	-1.8	1.2	0.8	0.1	0.1	0.1	0.1	-0.5
Context. condit. distance diff. score	2.1	2.5	4.8	-2.2	2.2	-2.2	2.2	2.0	-2.0	-0.4	0.4	0.4	0.4	0.4	1.4
Locomotion velocity, session 1	1.5	1.6	2.4	-1.4	1.4	-1.4	1.4	0.3	-1.5	0.7	1.3	1.3	1.3	1.1	1.4
Locomotion distance, session 1	0.4	0.5	0.9	-0.9	0.9	-0.9	0.9	0.4	-1.0	0.1	0.6	0.6	0.5	0.3	0.7
Locomotion velocity, session 2	0.3	0.3	0.9	-0.7	0.7	-0.7	0.7	0.9	-0.4	-0.6	-0.2	-0.2	-0.3	-0.3	0.1
Locomotion distance, session 2	0.0	0.1	0.3	0.2	-0.2	0.2	-0.2	-0.1	0.4	-0.3	-0.1	-0.1	-0.1	-0.2	-0.5
Locomotion velocity, session 3	0.2	0.2	0.4	-0.6	0.6	-0.6	0.6	0.5	-0.5	-0.1	0.3	0.2	0.2	0.2	0.3
Locomotion distance, session 3	1.9	2.0	3.7	-1.9	1.9	-1.9	1.9	1.3	-1.8	0.1	0.8	0.8	0.8	0.8	1.3
Stereotopy head waving bouts, day 3	1.9	2.2	4.6	2.2	-2.2	2.2	-2.2	-2.0	1.5	0.9	-0.2	-0.2	-0.2	-0.3	-0.6
Stereotopy head waving duration, day 3	0.1	0.2	0.4	0.4	-0.4	0.4	-0.4	-0.7	0.5	0.3	0.3	0.3	0.3	0.4	-0.4
Locomotion velocity, session 7	0.3	0.3	0.6	-0.7	0.7	-0.7	0.7	0.5	-0.7	0.1	0.4	0.4	0.4	0.4	0.7
Locomotion distance, session 7	0.4	0.5	1.7	-0.8	0.8	-0.8	0.8	1.3	-0.6	-0.7	-0.3	-0.3	-0.3	-0.4	0.3
Stereotopy head waving bouts, day 7	0.6	0.7	1.2	-0.8	0.8	-0.8	0.8	0.0	-1.0	0.7	0.9	0.9	0.9	0.8	1.1
Stereotopy head waving duration, day 7	0.1	0.1	0.3	-0.5	0.5	-0.5	0.5	0.4	-0.4	-0.1	0.2	0.2	0.2	0.2	0.3
Locomotion velocity, session 8	4.1	4.9	9.8	-3.1	3.1	-3.1	3.1	2.7	-2.5	-0.5	0.9	0.9	0.8	1.0	1.5
Locomotion distance, session 8	0.8	1.2	2.5	-1.6	1.6	-1.6	1.6	1.4	-1.3	-0.5	0.2	0.2	0.2	0.2	0.8
Degree of sensitization distance	1.9	2.0	2.6	1.4	-1.4	1.4	-1.4	0.1	1.5	-1.1	-1.5	-1.5	-1.5	-1.6	-1.4
Degree of sensitization stereotypy	1.7	1.9	3.3	-1.8	1.8	-1.8	1.8	1.1	-1.8	0.3	0.8	0.8	0.9	0.8	1.6
Conditioned locomotion	0.2	0.3	0.6	-0.3	0.3	-0.3	0.3	-0.4	-0.2	0.5	0.7	0.8	0.8	0.8	0.2
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.2	0.2	-0.2	0.2	0.4	-0.2	-0.3	-0.3	-0.3	-0.3	-0.4	0.1
Cocaine response after cond. not corrected	0.2	0.2	0.6	-0.6	0.6	-0.6	0.6	0.3	-0.7	0.2	0.2	0.2	0.2	0.1	0.8
Cocaine response before conditioning	0.8	0.9	1.9	-0.3	0.3	-0.3	0.3	-0.8	-1.0	1.4	1.2	1.2	1.1	1.1	1.4
Saline control response	0.4	0.6	1.6	0.1	-0.1	0.1	-0.1	0.7	0.9	-1.3	-0.9	-0.8	-0.8	-0.8	-1.2
Bone: connectivity density	0.8	1.3	2.4	-1.1	1.1	-1.1	1.1	0.2	-1.5	0.9	1.1	1.1	1.1	1.0	1.6
Bone: cortical apparent density	0.1	0.2	0.4	0.4	-0.4	0.4	-0.4	-0.7	0.4	0.3	0.3	0.2	0.3	0.2	-0.4
Bone: cortical area	0.6	0.9	1.8	0.3	-0.3	0.3	-0.3	1.0	0.6	-1.3	-1.3	-1.3	-1.3	-1.2	-0.8
Bone: cortical porosity	0.3	0.3	0.8	-0.3	0.3	-0.3	0.3	-0.4	-0.6	0.8	0.7	0.8	0.8	0.6	0.9
Bone: cortical porosity	0.4	0.4	0.9	-0.2	0.2	-0.2	0.2	-0.5	-0.6	0.9	0.7	0.8	0.8	0.6	1.0
Bone: cortical thickness	0.1	0.1	0.2	0.5	-0.5	0.5	-0.5	-0.2	0.3	0.0	-0.2	-0.2	-0.2	-0.3	-0.0
Bone: cortical thickness	0.3	0.3	1.0	-0.6	0.6	-0.6	0.6	1.0	-0.6	-0.6	-0.3	-0.4	-0.3	-0.6	0.5
Bone: cortical tissue density	0.1	0.2	0.5	0.4	-0.4	0.4	-0.4	-0.7	0.3	0.4	0.4	0.4	0.4	0.3	-0.2
Condit. Reinf. active minus inactive responses	1.3	1.5	2.3	1.0	-1.0	1.0	-1.0	0.4	1.4	-1.3	-1.4	-1.4	-1.3	-1.5	-1.5
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.2	1.0	-1.0	1.0	-1.0	0.3	1.4	-1.2	-1.3	-1.3	-1.2	-1.3	-1.5
Condit. Reinf. active responses	0.8	1.0	1.5	1.0	-1.0	1.0	-1.0	-0.1	1.2	-0.8	-1.0	-0.9	-0.9	-1.0	-1.2
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.2	-0.2	0.2	-0.2	-0.2	0.1	0.0	-0.0	-0.0	-0.0	-0.0	-0.1
Incentive salience index mean	0.8	0.9	1.7	0.5	-0.5	0.5	-0.5	0.7	0.8	-1.3	-1.2	-1.2	-1.2	-1.3	-1.1
Condit. Reinf. lever presses	0.2	0.3	1.0	-0.6	0.6	-0.6	0.6	1.0	-0.4	-0.6	-0.3	-0.3	-0.3	-0.3	0.1
Condit. Reinf. active minus inactive responses	2.3	3.0	7.7	-0.7	0.7	-0.7	0.7	2.6	0.4	-2.8	-2.1	-2.1	-2.1	-2.0	-1.3
Condit. Reinf. active-inactive response ratio	0.9	1.1	3.1	-0.8	0.8	-0.8	0.8	1.8	-0.1	-1.7	-1.0	-1.1	-1.1	-1.0	-0.6
Condit. Reinf. active responses	3.3	4.7	11.8	-0.5	0.5	-0.5	0.5	3.0	0.8	-3.4	-2.7	-2.8	-2.8	-2.6	-1.9
Condit. Reinf. inactive responses	1.7	2.2	4.2	0.5	-0.5	0.5	-0.5	1.2	1.3	-2.0	-1.9	-2.0	-2.0	-1.9	-1.7
Condit. Reinf. lever presses	4.0	5.5	17.1	-2.6	2.6	-2.6	2.6	4.1	-0.8	-3.3	-1.7	-1.7	-1.7	-1.3	-1.0
Condit. Reinf. lever reinforcers received	3.4	4.7	12.1	-0.8	0.8	-0.8	0.8	3.2	0.6	-3.5	-2.7	-2.7	-2.7	-2.6	-1.8
Conditioned reinforcement - actives	0.6	1.0	2.2	-1.3	1.3	-1.3	1.3	1.2	-1.5	0.1	0.3	0.3	0.2	0.4	1.2
Conditioned reinforcement - inactives	0.6	0.9	2.0	-0.6	0.6	-0.6	0.6	-0.5	-0.9	1.4	1.2	1.1	1.1	1.3	1.0
Conditioned locomotion	2.6	3.4	6.5	-2.3	2.3	-2.3	2.3	1.2	-2.5	0.9	1.2	1.2	1.2	1.3	2.4
Patch foraging indifference point 0 sec	0.4	0.8	2.4	-0.8	0.8	-0.8	0.8	1.5	0.0	-1.4	-0.7	-0.6	-0.7	-0.6	-0.8
Patch foraging indifference point AUC	0.2	0.3	0.7	-0.0	0.0	-0.0	0.0	0.6	0.2	-0.8	-0.7	-0.6	-0.7	-0.7	-0.5
Delay disc. indifference point, 0s delay	0.4	0.5	1.3	-0.3	0.3	-0.3	0.3	1.1	-0.3	-0.8	-0.9	-0.9	-0.9	-0.9	0.1
Delay disc. indifference point, 16s delay	0.7	0.8	1.4	-1.2	1.2	-1.2	1.2	0.4	-0.7	0.1	0.8	0.9	0.8	0.9	0.3
Delay disc. indifference point, 2s delay	0.4	0.4	1.2	-0.9	0.9	-0.9	0.9	1.1	-0.7	-0.3	-0.3	-0.2	-0.2	-0.0	0.4
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	-0.3	0.3	-0.3	0.3	-0.3	-0.0	0.2	0.6	0.6	0.6	0.6	-0.3
Delay disc. indifference point, 4s delay	1.1	1.2	3.7	-0.8	0.8	-0.8	0.8	1.9	-0.1	-1.5	-1.2	-1.2	-1.3	-1.0	-0.6
Delay disc. indifference point, 8s delay	0.6	0.7	1.6	-1.2	1.2	-1.2	1.2	0.8	-0.8	-0.3	0.4	0.4	0.4	0.4	0.4
Indifference point function ln k	0.4	0.7	1.0	-1.0	1.0	-1.0	1.0	0.0	-0.8	0.5	0.9	1.0	0.9	1.0	0.6
Indifference point function log k	0.4	0.7	1.0	-1.0	1.0	-1.0	1.0	0.0	-0.8	0.5	0.9	1.0	0.9	1.0	0.6
Patch foraging total patch changes 0 sec	0.4	0.8	2.4	-0.9	0.9	-0.9	0.9	1.6	-0.1	-1.3	-0.6	-0.6	-0.7	-0.6	-0.7
Patch foraging total patch changes 12 sec	0.6	0.7	1.7	0.2	-0.2	0.2	-0.2	0.9	0.4	-1.1	-1.1	-1.2	-1.3	-1.3	-0.6
Patch foraging total patch changes 18 sec	1.0	1.5	3.9	-0.2	0.2	-0.2	0.2	1.7	0.5	-2.0	-1.6	-1.5	-1.6	-1.6	-1.2
Patch foraging total patch changes 24 sec	0.5	0.8	1.9	0.2	-0.2	0.2	-0.2	0.9	0.5	-1.3	-1.2	-1.2	-1.3	-1.4	-0.8
Patch foraging total patch changes 6 sec	0.1	0.1	0.2	-0.5	0.5	-0.5	0.5	0.4	0.0	-0.3	0.1	0.2	0.1	0.1	-0.4
Patch foraging time to switch 0 sec	0.9	1.7	4.9	1.4	-1.4	1.4	-1.4	-2.2	0.3	2.0	1.1	1.0	1.0	0.9	0.7
Patch foraging water rate 0 sec	0.6	1.3	3.8	-1.4	1.4	-1.4	1.4	1.9	-0.7	-1.4	-0.7	-0.6	-0.6	-0.5	-0.1
Patch foraging water rate 12 sec	0.4	0.8	1.7	-1.3	1.3	-1.3	1.3	1.3	-0.5	-0.9	-0.0	-0.2	0.0	0.1	-0.1
Patch foraging water rate 18 sec	0.4	0.6	1.6	-0.7	0.7	-0.7	0.7	1.2	0.2	-1.3	-0.7	-0.5	-0.5	-0.6	-0.7
Patch foraging water rate 24 sec	1.1	1.6	3.4	-1.8	1.8	-1.8	1.8	1.0	-1.1	-0.1	0.7	0.8	0.9	0.9	0.6
Patch foraging water rate 6 sec	0.5	0.7	1.4	-1.2	1.2	-1.2	1.2	0.7	-0.9	-0.0	0.6	0.6	0.7	0.6	0.6
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.5	-0.1	0.1	-0.1	0.1	-0.2	-0.4	0.6	0.2	0.2	0.2	0.1	0.7
Distance traveled before self-admin	0.1	0.1	0.2	0.4	-0.4	0.4	-0.4	-0.2	0.3	0.2	0.1	0.0	0.2	0.1	-0.4
Distance traveled after self-admin	1.1	1.4	3.4	0.7	-0.7	0.7	-0.7	-1.7	-0.2	1.8	1.4	1.4	1.5	1.3	0.7
Extensor digitorum longus weight	0.5	2.0	4.1	0.9	-0.9	0.9	-0.9	0.7	1.7	-1.7	-1.7	-1.7	-1.7	-1.5	-2.0
Bone: elastic displacement	0.3	0.4	0.8	-0.3	0.3	-0.3	0.3	-0.5	-0.4	0.8	0.8	0.9	0.8	0.8	0.5
Bone: elastic work	1.2	1.6	2.8	-0.8	0.8	-0.8	0.8	-0.6	-1.1	1.4	1.6	1.7	1.7	1.6	1.3
Bone: endosteal estimation	1.0	2.1	4.7	0.1	-0.1	0.1	-0.1	1.8	0.7	-2.2	-1.9	-2.0	-2.0	-1.9	-1.3
Bone: endosteal perimeter	1.1	2.4	6.2	-0.7	0.7	-0.7	0.7	2.5	0.3	-2.4	-1.9	-1.9	-1.9	-1.6	-1.2
Epididymis fat weight	0.8	2.8	4.6	2.1	-2.1	2.1	-2.1	-0.9	2.1	-0.3	-1.4	-1.5	-1.3	-1.3	-1.7
Delta time in closed arm before/after self-admin	0.7	0.6	2.4	0.1	-0.1	0.1	-0.1	0.6	1.0	-1.4	-0.7	-0.7	-0.7	-0.7	-1.5
Delta time in open arm before/after self-admin	0.9	0.9	2.4	-0.6	0.6	-0.6	0.6	1.5	-0.2	-1.2	-1.2	-1.2	-1.1	-0.9	-0.5
Diff in mean of infusions in LGA sessions	1.4	1.7	4.6	1.1	-1.1	1.1	-1.1	-2.2	0.6	1.8	1.4	1.3	1.1	1.3	0.1
Delay discount exponential model param	0.6	0.6	1.4	1.2	-1.2	1.2	-1.2	-0.8	0.8	0.2	-0.3	-0.3	-0.3	-0.4	-0.3
Extinction: sum of active levers before priming	0.4	0.5	1.2	-0.1	0.1	-0.1	0.1	0.6	0.7	-1.0	-0.9	-0.9	-0.8	-0.7	-1.1
Active lever presses in extinction session 6	1.4	1.4	2.0	-1.2	1.2	-1.2	1.2	-0.3	-1.3	1.3	1.4	1.3	1.3	1.4	1.1
Bone: final force	0.2	0.4	0.7	-0.7	0.7	-0.7	0.7	0.6	-0.8	0.2	0.4	0.3	0.4	0.4	0.8
Bone: final moment	0.2	0.3	0.5	-0.6	0.6	-0.6	0.6	0.6	-0.7	0.1	0.2	0.2	0.2	0.3	0.7
Food consumed during 24 hour testing period	0.8	1.0	1.9	-1.4	1.4	-1.4	1.4	0.9	-1.3	0.1	0.5	0.5	0.5	0.7	1.0
Glucose	0.2	0.4	1.1	-0.3	0.3	-0.3	0.3	1.1	0.0	-0.8	-0.9	-0.8	-0.8	-0.5	-0.3
Heart weight	0.2	0.3	0.6	-0.5	0.5	-0.5	0.5	0.7	0.2	-0.8	-0.4	-0.5	-0.3	-0.3	-0.7
Delay discount hyperbolic model param	0.5	0.6	1.2	1.1	-1.1	1.1	-1.1	-1.1	0.7	0.5	-0.0	-0.0	0.0	-0.1	-0.2
Intermittent access intake day 1-15 change	0.6	1.3	2.6	-1.6	1.6	-1.6	1.6	0.9	-1.3	0.2	0.6	0.6	0.6	0.8	1.0
Intermittent access intake escalation	0.9	1.8	3.6	-1.9	1.9	-1.9	1.9	1.1	-1.5	0.2	0.6	0.7	0.7	0.8	1.2
Intermittent access intake escalation 2	0.5	0.6	1.1	-1.0	1.0	-1.0	1.0	0.7	-1.0	0.2	0.1	0.2	0.2	0.3	1.0
Intermitt. access day 1 inactive lever presses	0.3	1.0	2.8	0.2	-0.2	0.2	-0.2	-1.4	-0.6	1.7	1.1	1.2	1.1	1.0	1.4
Intermitt. access day 15 inactive lever presses	0.4	0.9	2.4	0.6	-0.6	0.6	-0.6	-1.6	0.1	1.5	1.1	1.1	1.0	1.0	0.4
Intermitt. access escalation Index	0.5	0.7	1.4	-0.5	0.5	-0.5	0.5	-0.3	-0.8	1.0	1.2	1.0	1.1	1.1	0.8
Intermittent access day 1 total infusions	0.4	0.7	1.6	-1.2	1.2	-1.2	1.2	1.3	-0.8	-0.3	0.1	0.0	0.0	0.3	0.2
Intermittent access day 15 total infusions	1.9	2.8	5.8	-2.4	2.4	-2.4	2.4	1.8	-2.0	0.1	0.6	0.6	0.6	1.0	1.2
Intermittent access terminal intake (last 3 days)	1.0	1.3	2.6	-1.6	1.6	-1.6	1.6	1.5	-1.5	0.0	0.1	0.1	0.1	0.5	1.0
Intermittent access total infusions	0.8	0.9	2.3	-1.3	1.3	-1.3	1.3	1.5	-1.1	-0.2	-0.2	-0.2	-0.2	0.1	0.5
Intermittent access day 1 locomotion	0.7	0.9	1.5	-1.1	1.1	-1.1	1.1	0.4	-1.2	0.7	0.8	0.7	0.7	1.0	1.1
Intermittent access day 15 total locomotion	0.5	0.9	1.6	-1.2	1.2	-1.2	1.2	0.7	-1.3	0.6	0.6	0.6	0.6	0.9	1.2
Intermittent access total locomotion	0.4	0.4	0.8	-0.8	0.8	-0.8	0.8	0.8	-0.9	0.3	0.1	0.1	0.1	0.5	0.7
Intermittent access standard deviation	0.4	0.8	1.3	0.5	-0.5	0.5	-0.5	0.6	0.9	-0.9	-1.1	-1.1	-1.1	-1.1	-1.0
Left kidney weight	1.4	6.5	9.5	2.7	-2.7	2.7	-2.7	-0.2	3.1	-1.9	-2.5	-2.7	-2.5	-2.6	-2.9
Right kidney weight	1.5	6.8	9.4	2.6	-2.6	2.6	-2.6	-0.1	3.1	-2.1	-2.7	-2.9	-2.7	-2.9	-2.9
Cocaine induced anxiety	0.8	1.1	2.4	1.6	-1.6	1.6	-1.6	-1.4	0.9	0.7	0.5	0.5	0.4	0.2	-0.2
Post-drug Anxiety	0.3	0.4	0.6	0.8	-0.8	0.8	-0.8	-0.8	0.8	0.1	0.4	0.4	0.3	0.2	-0.5
Baseline Anxiety	0.7	0.8	1.6	-1.3	1.3	-1.3	1.3	1.3	-0.4	-0.9	-0.3	-0.3	-0.2	-0.1	-0.3
Tail length	2.4	9.2	13.7	2.7	-2.7	2.7	-2.7	0.6	3.5	-2.9	-3.5	-3.5	-3.4	-3.3	-3.7
Length with tail	2.1	9.1	13.7	3.1	-3.1	3.1	-3.1	-0.1	3.7	-2.2	-3.2	-3.2	-3.1	-3.0	-3.5
Length without tail	0.5	1.5	2.9	1.7	-1.7	1.7	-1.7	-1.4	1.6	0.5	-0.3	-0.3	-0.4	-0.3	-1.0
Times rat made contact with spout	0.8	1.0	1.8	1.4	-1.4	1.4	-1.4	-0.8	1.2	-0.1	-0.6	-0.6	-0.6	-0.5	-0.8
Lifetime Intake	1.0	1.2	2.6	-1.5	1.5	-1.5	1.5	1.6	-1.4	-0.2	0.1	0.0	0.0	0.2	0.8
Liver weight, left	1.1	1.7	2.9	1.3	-1.3	1.3	-1.3	0.1	1.2	-0.7	-1.7	-1.7	-1.7	-1.5	-1.1
Liver weight, right	3.9	6.7	10.2	3.2	-3.2	3.2	-3.2	-1.0	2.9	-1.0	-2.4	-2.5	-2.4	-2.5	-2.3
Locomotor activity	0.5	0.7	1.7	1.1	-1.1	1.1	-1.1	-0.7	1.3	-0.6	-0.4	-0.4	-0.4	-0.6	-1.0
Locomotor testing distance	1.4	2.6	4.1	1.3	-1.3	1.3	-1.3	0.4	1.8	-2.0	-1.7	-1.8	-1.8	-2.0	-1.9
Locomotor testing rearing	2.3	4.6	6.2	2.2	-2.2	2.2	-2.2	-0.0	2.5	-1.9	-2.1	-2.3	-2.3	-2.3	-2.3
Locomotion in novel chamber	1.5	2.0	4.1	-1.5	1.5	-1.5	1.5	0.7	-2.0	0.9	1.5	0.8	0.8	1.4	1.8
Locomotion in novel chamber post-restriction	1.8	2.9	5.7	-2.4	2.4	-2.4	2.4	1.6	-2.1	0.1	1.1	0.9	0.9	1.3	1.2
Fecal boli incidents, locomotor time 1	1.4	2.0	4.0	-1.9	1.9	-1.9	1.9	1.2	-2.0	-0.1	0.5	0.6	0.6	0.3	1.6
Change in fecal boli incidents, locomotor task	0.8	0.8	1.8	1.1	-1.1	1.1	-1.1	-1.3	0.9	0.7	0.6	0.5	0.5	0.5	-0.5
Time >=10cm from walls, locomotor time 1	1.2	1.3	2.4	-1.6	1.6	-1.6	1.6	0.9	-1.5	0.2	0.6	0.7	0.8	0.9	0.9
Bouts of movement, locomotor time 1	0.2	0.3	0.6	-0.7	0.7	-0.7	0.7	0.8	-0.0	-0.7	-0.1	-0.1	-0.1	0.0	-0.3
Total resting periods, locomotor time 1	0.4	0.4	0.9	-1.0	1.0	-1.0	1.0	0.5	-0.4	-0.2	0.4	0.5	0.5	0.6	0.2
Rest time, locomotor task time 1	0.8	1.0	1.6	-1.3	1.3	-1.3	1.3	0.3	-1.0	0.3	1.0	1.0	1.0	1.0	0.5
Distance moved, locomotor task time 1	1.0	1.5	2.7	0.9	-0.9	0.9	-0.9	0.7	1.1	-1.3	-1.7	-1.5	-1.6	-1.6	-1.2
Vertical activity count, locomotor time 1	0.4	0.9	2.1	0.5	-0.5	0.5	-0.5	0.7	0.8	-1.1	-1.5	-1.2	-1.3	-1.2	-1.0
Time >=10cm from walls, locomotor time 2	0.4	0.6	1.7	-0.5	0.5	-0.5	0.5	1.3	-0.3	-1.0	-1.0	-0.9	-0.8	-0.7	-0.4
Bouts of movement, locomotor time 2	0.1	0.2	0.4	0.2	-0.2	0.2	-0.2	0.4	0.4	-0.6	-0.6	-0.6	-0.7	-0.5	-0.4
Total resting periods, locomotor time 2	0.0	0.1	0.2	0.1	-0.1	0.1	-0.1	0.3	0.2	-0.4	-0.4	-0.4	-0.4	-0.4	-0.2
Rest time, locomotor task time 2	0.6	0.7	1.7	0.5	-0.5	0.5	-0.5	-1.3	-0.2	1.3	1.2	0.9	0.9	0.8	0.6
Distance moved, locomotor task time 2	1.4	1.6	3.6	-0.3	0.3	-0.3	0.3	1.9	0.2	-1.8	-1.9	-1.7	-1.7	-1.6	-0.6
Vertical activity count, locomotor time 2	1.0	1.4	3.5	0.0	-0.0	0.0	-0.0	1.4	0.6	-1.6	-1.9	-1.6	-1.6	-1.6	-0.8
Light reinforcement 1	0.4	1.1	2.2	1.5	-1.5	1.5	-1.5	-1.4	1.1	0.4	-0.4	-0.4	-0.2	-0.4	-0.6
Light reinforcement 2	0.1	0.2	0.6	0.2	-0.2	0.2	-0.2	-0.8	-0.2	0.6	0.4	0.3	0.3	0.3	0.5
Bone: marrow area	0.9	1.9	4.2	0.2	-0.2	0.2	-0.2	1.6	0.7	-2.0	-1.9	-1.9	-1.9	-1.8	-1.3
Bone: maximum diameter	0.9	1.6	3.9	-0.3	0.3	-0.3	0.3	2.0	0.4	-1.9	-1.7	-1.6	-1.6	-1.4	-1.0
Bone: maximum force	0.5	0.8	1.4	-1.1	1.1	-1.1	1.1	0.7	-1.2	0.3	0.7	0.6	0.7	0.8	1.1
Bone: maximum moment	0.4	0.7	1.1	-1.0	1.0	-1.0	1.0	0.8	-1.0	0.2	0.5	0.5	0.5	0.6	0.9
Mean time between licks in bursts	1.1	2.6	5.4	0.4	-0.4	0.4	-0.4	1.6	0.9	-2.2	-2.3	-2.3	-2.3	-2.2	-1.2
Mean num. licks in bursts	0.6	1.0	2.7	-1.3	1.3	-1.3	1.3	1.6	-0.8	-0.9	-0.4	-0.4	-0.4	-0.3	0.2
Cd content in liver	0.8	0.9	2.6	0.8	-0.8	0.8	-0.8	0.1	1.2	-1.0	-0.9	-0.9	-0.9	-0.9	-1.6
Co content in liver	0.7	0.8	2.1	0.1	-0.1	0.1	-0.1	1.2	0.4	-1.4	-1.2	-1.2	-1.2	-1.3	-0.4
Cu content in liver	2.8	3.3	6.2	1.5	-1.5	1.5	-1.5	0.3	2.1	-1.9	-2.0	-2.0	-2.0	-2.1	-2.5
Fe content in liver	0.1	0.1	0.4	-0.2	0.2	-0.2	0.2	0.2	-0.4	0.1	0.0	0.0	0.0	-0.1	0.6
K content in liver	0.4	0.3	0.9	0.8	-0.8	0.8	-0.8	-0.9	0.4	0.5	0.2	0.1	0.1	0.1	-0.0
Mg content in liver	0.0	0.0	0.1	0.2	-0.2	0.2	-0.2	-0.3	0.0	0.2	0.2	0.2	0.2	0.1	-0.1
Mn content in liver	1.1	1.2	2.9	-0.2	0.2	-0.2	0.2	-1.0	-1.0	1.7	1.4	1.5	1.5	1.4	1.2
Na content in liver	0.4	0.4	1.3	-0.2	0.2	-0.2	0.2	-0.5	-0.8	1.0	0.7	0.7	0.7	0.6	1.1
Rb content in liver	0.2	0.2	1.1	0.4	-0.4	0.4	-0.4	0.1	0.7	-0.5	-0.4	-0.4	-0.4	-0.3	-1.1
Se content in liver	1.4	1.7	5.0	0.9	-0.9	0.9	-0.9	-2.2	-0.2	2.1	1.4	1.4	1.4	1.2	0.5
Sr content in liver	0.5	0.4	0.7	-0.9	0.9	-0.9	0.9	0.7	-0.8	-0.0	0.2	0.2	0.2	0.3	0.7
Zn content in liver	2.1	2.3	4.9	0.6	-0.6	0.6	-0.6	1.3	1.2	-2.2	-1.9	-1.9	-1.9	-2.0	-1.8
Bone: minimum diameter	1.5	2.8	5.0	1.0	-1.0	1.0	-1.0	1.1	1.4	-2.1	-2.2	-2.2	-2.2	-2.2	-1.7
Time in familiar zone, hab. session 1	0.0	0.0	0.0	-0.2	0.2	-0.2	0.2	0.2	-0.2	0.0	-0.0	0.0	0.1	0.0	0.1
Time in novel zone, hab. session 1	0.6	0.6	1.1	0.9	-0.9	0.9	-0.9	-0.4	1.1	-0.5	-0.5	-0.6	-0.6	-0.6	-1.0
Total zone transitions, hab. session 1	0.6	0.9	2.0	-0.2	0.2	-0.2	0.2	-0.9	-0.4	1.1	1.4	1.4	1.4	1.4	0.5
Total locomotion distance, hab. session 1	4.1	5.8	11.7	3.4	-3.4	3.4	-3.4	-2.6	2.7	0.4	-1.2	-1.2	-1.2	-1.4	-1.5
Locomotion velocity, hab. session 1	3.4	4.8	9.8	3.1	-3.1	3.1	-3.1	-2.5	2.3	0.5	-1.0	-1.0	-1.0	-1.2	-1.2
Time in familiar zone, hab. session 2	0.4	0.4	1.1	-0.2	0.2	-0.2	0.2	0.9	0.3	-1.0	-0.9	-0.8	-0.8	-0.6	-0.7
Time in novel zone, hab. session 2	0.1	0.1	0.2	-0.3	0.3	-0.3	0.3	0.2	-0.5	0.2	0.2	0.2	0.1	0.0	0.4
Total zone transitions, hab. session 2	0.4	0.5	1.1	-0.5	0.5	-0.5	0.5	-0.3	-0.3	0.5	1.0	1.0	1.0	1.0	0.2
Total locomotion distance, hab. session 2	3.2	4.1	7.6	2.8	-2.8	2.8	-2.8	-1.8	2.4	-0.3	-1.3	-1.3	-1.3	-1.5	-1.7
Locomotion velocity, hab. session 2	3.6	4.8	8.5	2.9	-2.9	2.9	-2.9	-1.9	2.7	-0.4	-1.4	-1.4	-1.4	-1.6	-2.0
Novel to familiar place preference ratio	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.2	0.1	0.2	0.1	0.1	0.0	0.1	-0.0
Novelty place preference	0.0	0.0	0.0	-0.0	0.0	-0.0	0.0	0.0	0.1	0.0	-0.0	-0.1	-0.1	0.0	-0.1
Time in novel zone, NPP test	0.0	0.0	0.1	-0.3	0.3	-0.3	0.3	0.3	-0.0	-0.1	-0.0	-0.0	-0.1	0.1	-0.1
Total zone transitions, NPP test	0.7	1.0	1.4	-1.1	1.1	-1.1	1.1	0.2	-1.0	0.5	1.2	1.2	1.1	1.1	0.8
Total locomotion distance, NPP test	1.9	2.6	5.0	2.2	-2.2	2.2	-2.2	-1.4	1.6	-0.0	-1.1	-1.1	-1.1	-1.4	-0.8
Locomotion velocity, NPP test	2.3	3.2	6.4	2.5	-2.5	2.5	-2.5	-1.8	1.8	0.2	-1.1	-1.1	-1.1	-1.4	-0.8
Intraocular pressure	3.0	4.3	8.8	-3.0	3.0	-3.0	3.0	2.2	-2.3	-0.3	0.8	0.9	0.8	1.1	1.5
Delta distance traveled before/after self-admin	0.5	0.6	1.2	0.1	-0.1	0.1	-0.1	-1.1	-0.4	1.1	1.0	1.0	1.0	0.9	0.7
Delta ambulatory time before/after self-admin	0.5	0.7	1.3	-0.2	0.2	-0.2	0.2	-0.9	-0.5	1.1	1.1	1.1	1.1	1.2	0.7
Parametrial fat weight	0.6	1.4	2.7	1.6	-1.6	1.6	-1.6	-1.5	1.4	0.4	-0.1	-0.1	-0.1	-0.2	-0.9
Pavlov. Cond. lever latency	0.4	0.5	2.0	0.7	-0.7	0.7	-0.7	-1.4	0.5	0.9	0.6	0.6	0.6	0.5	-0.2
Pavlov. Cond. magazine entry latency	0.7	0.9	2.6	-0.4	0.4	-0.4	0.4	1.6	0.1	-1.5	-1.1	-1.1	-1.1	-1.1	-0.6
Pavlov. Cond. change in total contacts	0.6	0.6	2.2	-0.8	0.8	-0.8	0.8	1.5	-0.8	-0.8	-0.7	-0.6	-0.6	-0.7	0.6
Pavlov. Cond. index score	0.8	1.0	3.0	-0.4	0.4	-0.4	0.4	1.7	0.0	-1.6	-1.2	-1.2	-1.2	-1.2	-0.5
Pavlov. Cond. latency score	0.7	0.9	2.7	-0.4	0.4	-0.4	0.4	1.6	-0.1	-1.4	-1.2	-1.1	-1.1	-1.1	-0.3
Pavlov. Cond. lever contacts	0.4	0.4	1.5	-0.3	0.3	-0.3	0.3	1.2	-0.1	-1.0	-0.8	-0.8	-0.7	-0.8	-0.1
Pavlov. Cond. magazine entry number	0.9	1.1	2.9	0.4	-0.4	0.4	-0.4	-1.7	-0.2	1.7	1.2	1.2	1.3	1.2	0.7
Pavlov. Cond. intertrial magazine entries	0.4	0.4	1.3	0.9	-0.9	0.9	-0.9	-1.2	0.4	0.6	0.2	0.2	0.2	0.1	-0.0
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	2.6	-0.5	0.5	-0.5	0.5	1.6	-0.1	-1.4	-1.0	-1.0	-1.0	-1.0	-0.3
Pavlov. Cond. response bias	0.4	0.5	1.3	-0.2	0.2	-0.2	0.2	1.1	0.1	-1.1	-0.8	-0.8	-0.8	-0.9	-0.4
Pavlov. Cond. lever latency	4.9	6.6	19.6	3.2	-3.2	3.2	-3.2	-4.4	1.4	3.2	1.3	1.3	1.3	1.0	0.6
Pavlov. Cond. magazine entry latency	2.9	3.5	7.4	-2.7	2.7	-2.7	2.7	2.6	-1.7	-1.2	0.3	0.3	0.2	0.3	0.5
Pavlov. Cond. change in total contacts	2.6	4.1	12.6	-2.3	2.3	-2.3	2.3	3.5	-0.7	-2.8	-1.3	-1.3	-1.3	-1.1	-0.9
Pavlov. Cond. index score	4.2	5.7	16.7	-3.1	3.1	-3.1	3.1	4.1	-1.5	-2.8	-1.0	-1.0	-1.0	-0.7	-0.3
Pavlov. Cond. latency score	4.0	5.2	14.7	-3.1	3.1	-3.1	3.1	3.8	-1.6	-2.5	-0.7	-0.7	-0.7	-0.5	-0.2
Pavlov. Cond. lever contacts	4.4	6.1	18.2	-3.0	3.0	-3.0	3.0	4.3	-1.0	-3.3	-1.3	-1.4	-1.4	-1.1	-1.0
Pavlov. Cond. magazine entry number	5.2	6.4	16.5	3.5	-3.5	3.5	-3.5	-4.1	2.2	2.2	0.4	0.4	0.4	0.2	-0.4
Pavlov. Cond. intertrial magazine entries	2.4	3.7	5.6	2.4	-2.4	2.4	-2.4	-0.9	2.2	-0.9	-1.7	-1.7	-1.7	-1.9	-1.6
Pavlov. Cond. lever-magazine prob. diff.	4.1	5.4	16.2	-3.0	3.0	-3.0	3.0	4.0	-1.4	-2.8	-1.0	-1.0	-1.1	-0.8	-0.4
Pavlov. Cond. response bias	5.4	7.3	21.5	-3.4	3.4	-3.4	3.4	4.6	-1.5	-3.3	-1.3	-1.3	-1.3	-1.1	-0.6
Time in closed arm before self-admin	0.5	0.6	0.9	-0.7	0.7	-0.7	0.7	-0.2	-0.8	0.7	0.9	0.9	0.9	0.9	0.9
Time in closed arm after self-admin	1.7	1.9	2.8	-1.2	1.2	-1.2	1.2	-0.2	-1.4	1.1	1.7	1.7	1.6	1.7	1.4
Time in open arm before self-admin	0.4	0.5	1.0	1.0	-1.0	1.0	-1.0	-1.0	0.7	0.4	0.0	-0.0	0.0	-0.3	-0.2
Time in open arm after self-admin	1.1	1.2	2.1	1.0	-1.0	1.0	-1.0	0.2	1.1	-0.9	-1.4	-1.5	-1.3	-1.3	-1.1
Bone: periosteal estimation	1.1	2.2	5.0	-0.1	0.1	-0.1	0.1	2.1	0.5	-2.2	-2.0	-2.1	-2.0	-1.9	-1.1
Bone: periosteal perimeter	1.1	1.9	4.4	0.1	-0.1	0.1	-0.1	1.6	1.0	-2.1	-1.8	-1.8	-1.8	-1.5	-1.7
Bone: post-yield work	0.1	0.1	0.3	-0.0	0.0	-0.0	0.0	-0.3	-0.2	0.4	0.4	0.4	0.4	0.5	0.4
Progressive ratio test 1 active lever presses	0.7	0.9	1.3	-0.9	0.9	-0.9	0.9	0.0	-1.1	0.9	1.0	1.0	1.0	1.1	1.0
Progressive ratio test 1 breakpoint	0.7	0.9	1.3	-0.9	0.9	-0.9	0.9	0.1	-1.1	0.9	1.1	1.0	1.0	1.2	1.0
Progressive ratio test 1 inactive lever presses	0.7	0.9	2.1	-0.2	0.2	-0.2	0.2	-1.0	-0.7	1.4	1.3	1.2	1.3	1.2	1.1
Progressive ratio test 2 active lever presses	0.7	0.9	3.1	-1.1	1.1	-1.1	1.1	1.8	-0.8	-0.7	-0.6	-0.7	-0.6	-0.4	0.2
Progressive ratio test 2 breakpoint	0.8	1.0	3.3	-1.2	1.2	-1.2	1.2	1.8	-0.9	-0.7	-0.6	-0.7	-0.6	-0.4	0.3
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.4	-0.5	0.5	-0.5	0.5	0.6	-0.4	0.0	0.1	-0.1	0.1	0.1	0.2
Incentive Sensitization - Responses	0.8	1.1	3.5	-0.8	0.8	-0.8	0.8	1.9	-0.2	-1.2	-1.2	-1.3	-1.2	-1.0	-0.5
Incentive Sensitization - Breakpoint	0.8	1.0	3.3	-0.8	0.8	-0.8	0.8	1.8	-0.2	-1.1	-1.2	-1.3	-1.1	-0.9	-0.4
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	0.5	-0.5	0.5	-0.5	-0.6	0.6	0.3	-0.3	-0.3	-0.2	-0.1	-0.5
Progressive ratio	1.1	1.6	3.4	-1.8	1.8	-1.8	1.8	1.1	-1.5	-0.1	0.8	0.7	0.7	0.7	0.9
Food seeking constrained by brief footshock	1.1	1.3	2.9	0.6	-0.6	0.6	-0.6	0.7	1.2	-1.7	-1.3	-1.4	-1.4	-1.5	-1.4
Seeking ratio, punishment vs. effort	2.5	3.6	5.1	2.3	-2.3	2.3	-2.3	-0.4	2.1	-1.0	-2.0	-1.9	-1.8	-1.9	-1.6
Retroperitoneal fat weight	4.8	20.4	32.9	5.5	-5.5	5.5	-5.5	-1.9	5.7	-1.9	-4.0	-4.0	-3.9	-3.8	-4.9
Reaction time number correct	0.4	0.8	2.1	0.1	-0.1	0.1	-0.1	-1.4	-0.2	1.1	1.2	1.3	1.4	1.1	0.6
Reaction time mean minus median	0.2	0.6	1.3	0.2	-0.2	0.2	-0.2	0.8	0.7	-1.1	-0.7	-0.9	-1.1	-0.9	-1.0
Reaction time mean minus median AUC	0.1	0.1	0.4	-0.1	0.1	-0.1	0.1	0.5	0.2	-0.7	-0.2	-0.4	-0.6	-0.3	-0.5
Reaction time num false alarms	0.4	0.6	1.1	1.0	-1.0	1.0	-1.0	-0.8	0.9	0.0	-0.4	-0.3	-0.3	-0.3	-0.8
Reaction time num false alarms AUC	0.0	0.1	0.2	0.4	-0.4	0.4	-0.4	-0.5	0.3	0.1	-0.1	0.1	0.0	-0.0	-0.2
Reaction time trials correct on left	0.4	0.8	2.1	0.1	-0.1	0.1	-0.1	-1.4	-0.2	1.1	1.2	1.3	1.4	1.1	0.6
Reaction time trials on left	0.4	0.8	2.0	0.0	-0.0	0.0	-0.0	-1.4	-0.2	1.1	1.2	1.2	1.4	1.1	0.6
Reaction time mean	0.1	0.2	0.5	0.7	-0.7	0.7	-0.7	-0.3	0.6	-0.0	-0.3	-0.3	-0.2	-0.4	-0.4
Reaction time mean AUC	0.1	0.1	0.2	0.4	-0.4	0.4	-0.4	-0.3	0.3	0.2	0.0	0.1	0.0	-0.1	-0.1
Median of all reaction times	0.1	0.2	0.3	0.6	-0.6	0.6	-0.6	-0.5	0.3	0.4	0.1	0.1	0.2	-0.1	0.1
Reaction time omissions	0.5	0.7	1.4	0.3	-0.3	0.3	-0.3	0.8	0.7	-1.2	-1.1	-1.1	-1.1	-1.2	-0.9
Reaction time false alarm rate	0.1	0.1	0.3	0.2	-0.2	0.2	-0.2	0.2	0.2	-0.2	-0.5	-0.4	-0.5	-0.4	-0.3
Reaction time premature initiation rate	3.3	4.5	7.3	1.7	-1.7	1.7	-1.7	0.5	2.2	-2.1	-2.7	-2.6	-2.6	-2.6	-2.2
Reaction time premature initiations	1.3	2.3	3.3	1.4	-1.4	1.4	-1.4	-0.1	1.8	-1.4	-1.8	-1.7	-1.6	-1.8	-1.6
Std. dev. reaction times	0.6	1.2	2.0	0.7	-0.7	0.7	-0.7	0.7	1.1	-1.4	-1.2	-1.3	-1.4	-1.4	-1.3
Reaction time trials completed	0.4	0.8	2.0	0.0	-0.0	0.0	-0.0	-1.4	-0.2	1.1	1.2	1.2	1.4	1.1	0.6
Reaction time trials AUC	0.3	0.6	1.8	0.2	-0.2	0.2	-0.2	-1.3	-0.0	0.9	1.0	1.0	1.2	0.9	0.4
Run reversals in cocaine runway, females	2.9	2.9	4.8	1.2	-1.2	1.2	-1.2	0.5	2.0	-1.9	-2.1	-2.0	-2.0	-2.0	-2.2
Run reversals in cocaine runway, males	1.6	1.6	3.6	-1.9	1.9	-1.9	1.9	0.9	-1.1	-0.1	0.5	0.7	0.8	0.9	0.4
Latency to leave start box in cocaine runway	0.9	1.0	2.5	1.4	-1.4	1.4	-1.4	-1.6	0.7	0.9	0.1	0.2	0.1	-0.2	0.1
Latency to leave start box in cocaine runway, F	1.4	1.6	3.5	1.9	-1.9	1.9	-1.9	-1.4	1.2	0.2	-0.6	-0.5	-0.7	-1.0	-0.4
Latency to leave start box in cocaine runway, M	0.5	0.5	1.1	-0.3	0.3	-0.3	0.3	-0.6	-0.5	1.1	0.8	0.8	0.9	0.8	0.8
Std. dev. time between licks in bursts	2.2	2.9	3.8	1.8	-1.8	1.8	-1.8	-0.1	1.9	-1.4	-1.9	-1.8	-1.9	-1.9	-1.8
Total sessions with >9 infusions	0.8	1.0	1.8	-1.3	1.3	-1.3	1.3	1.3	-1.3	-0.2	0.3	0.2	0.1	0.1	0.9
Short access day 1 total inactive lever presses	0.4	0.5	1.1	-1.1	1.1	-1.1	1.1	0.9	-0.6	-0.3	0.2	0.2	0.1	0.2	0.1
Short access day 10 total inactive lever presses	0.4	1.0	3.4	1.1	-1.1	1.1	-1.1	-1.8	0.9	1.1	0.7	0.7	0.6	0.6	-0.3
Short access day 1 total infusions	0.7	0.9	3.8	-1.0	1.0	-1.0	1.0	1.9	-0.7	-1.0	-0.6	-0.8	-0.7	-0.7	0.1
Short access day 10 total infusions	0.8	1.0	2.8	-1.3	1.3	-1.3	1.3	1.7	-1.1	-0.7	-0.2	-0.3	-0.3	-0.3	0.5
Short access total infusions	1.0	1.3	2.9	-1.6	1.6	-1.6	1.6	1.7	-1.4	-0.4	0.1	-0.0	0.0	0.0	0.7
Short access day 1 locomotion	2.0	2.5	5.2	-2.3	2.3	-2.3	2.3	1.7	-1.8	-0.1	0.6	0.6	0.6	0.8	1.1
Short access day 10 total locomotion	0.3	0.5	1.6	-0.9	0.9	-0.9	0.9	1.3	-0.5	-0.7	-0.4	-0.4	-0.5	-0.2	0.3
Short access total locomotion	0.5	0.6	1.2	-0.9	0.9	-0.9	0.9	0.5	-1.1	0.5	0.6	0.6	0.5	0.6	1.1
One hour access (0.3 mA shock)	0.5	0.5	1.6	-0.8	0.8	-0.8	0.8	1.3	-0.3	-0.8	-0.6	-0.5	-0.6	-0.4	-0.3
Compulsive drug intake	0.5	0.5	1.4	0.2	-0.2	0.2	-0.2	-1.2	-0.2	1.2	1.0	0.9	0.9	0.9	0.4
One hour access (shock baseline)	0.8	1.3	3.0	-1.6	1.6	-1.6	1.6	1.7	-1.1	-0.7	-0.2	-0.1	-0.2	-0.1	0.6
Social response proportion	1.5	1.7	3.7	1.9	-1.9	1.9	-1.9	-1.8	1.2	0.8	0.1	0.1	-0.0	-0.2	-0.4
Social responses	1.9	2.5	4.4	2.1	-2.1	2.1	-2.1	-1.0	2.1	-0.5	-0.9	-1.0	-1.0	-1.2	-1.6
Social time	0.8	1.1	3.4	1.3	-1.3	1.3	-1.3	-1.8	0.7	1.1	0.6	0.7	0.6	0.3	0.2
Soleus weight	1.4	4.3	6.4	2.2	-2.2	2.2	-2.2	-0.3	2.5	-1.5	-2.0	-2.0	-2.0	-2.0	-2.5
Bone: stiffness	0.2	0.3	0.6	-0.3	0.3	-0.3	0.3	-0.2	-0.5	0.7	0.7	0.6	0.7	0.8	0.7
Tibialis anterior weight	0.3	0.9	1.8	1.0	-1.0	1.0	-1.0	-0.2	1.3	-0.7	-1.0	-0.9	-0.9	-0.8	-1.3
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.2	-0.2	0.2	-0.2	0.2	0.3	-0.5	-0.4	-0.3	-0.3	-0.4	-0.4
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.7	-0.5	0.5	-0.5	0.5	0.8	-0.3	-0.8	-0.3	-0.3	-0.2	-0.2	-0.1
Time to tail flick, test, before self-admin	0.5	0.5	1.5	-0.5	0.5	-0.5	0.5	1.2	0.1	-1.2	-0.7	-0.7	-0.8	-0.7	-0.7
Time to tail flick, test, after self-admin	0.7	0.7	1.8	0.2	-0.2	0.2	-0.2	0.8	0.6	-1.4	-1.0	-1.0	-1.0	-1.2	-0.9
Delta time to tail flick, vehicle, before/after SA	0.6	0.5	1.0	-1.0	1.0	-1.0	1.0	0.6	-0.9	-0.1	0.4	0.3	0.4	0.4	0.7
Delta time to tail flick, test, before/after SA	0.4	0.4	1.3	0.8	-0.8	0.8	-0.8	-1.1	0.4	0.7	0.4	0.3	0.4	0.2	0.1
Tibia length	0.4	1.1	2.1	-1.4	1.4	-1.4	1.4	1.1	-1.4	-0.1	0.4	0.4	0.4	0.4	1.1
Ambulatory time before self-admin	0.2	0.3	0.6	-0.4	0.4	-0.4	0.4	-0.1	-0.4	0.7	0.7	0.7	0.8	0.8	0.3
Ambulatory time after self-admin	1.3	1.6	3.6	-0.1	0.1	-0.1	0.1	-1.3	-0.8	1.9	1.7	1.6	1.8	1.8	1.1
Bone: tissue strength	2.2	2.2	5.5	-0.2	0.2	-0.2	0.2	-1.6	-0.9	2.3	1.9	1.9	1.9	2.1	1.6
Total heroin consumption	0.0	0.0	0.2	0.0	-0.0	0.0	-0.0	-0.2	0.3	0.1	-0.1	-0.2	-0.2	0.0	-0.4
Bone: trabecular number	0.4	0.6	1.2	-0.2	0.2	-0.2	0.2	-0.7	-0.6	1.1	1.1	1.0	1.0	1.1	0.8
Bone: trabecular spacing	0.1	0.2	0.3	-0.6	0.6	-0.6	0.6	0.5	-0.5	-0.3	-0.0	0.1	0.1	-0.2	0.3
Bone: trabecular thickness	0.5	0.7	2.0	0.7	-0.7	0.7	-0.7	-0.0	1.2	-0.8	-0.7	-0.7	-0.8	-0.5	-1.4
Bone: trabecular tissue density	1.8	2.7	5.2	2.3	-2.3	2.3	-2.3	-1.9	2.2	0.2	-0.4	-0.5	-0.5	-0.5	-1.6
Water consumed over 24 hours	0.3	0.4	1.1	0.7	-0.7	0.7	-0.7	-1.0	0.5	0.6	0.4	0.4	0.4	0.4	-0.1
Number of responses in last shaping day	1.8	2.0	3.0	1.7	-1.7	1.7	-1.7	-0.4	1.5	-0.5	-1.4	-1.4	-1.4	-1.5	-1.1