Hub : Genes

Kcnmb2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg gene expression Kcnmb2 0.21 0.12 4.7e-04 0.08 0.11 0.16 0.12 3.0e-03 7.2e-04 3.8e-05 4.4e-04
2 Brain mRNA stability Kcnmb2 0.05 0.03 2.7e-03 0.01 0.02 0.01 0.01 1.3e-02 5.9e-03 5.9e-02 2.0e-02
3 Adipose gene expression Kcnmb2 0.04 0.03 8.5e-04 0.02 0.01 0.01 0.01 5.7e-03 2.7e-02 4.7e-02 4.0e-02
4 PL gene expression Kcnmb2 0.04 0.02 1.5e-04 0.03 0.03 0.03 0.03 7.4e-04 1.2e-04 2.4e-04 5.5e-04
5 Adipose alternative polyA XM_039101980.1 0.05 0.04 2.4e-04 0.01 0.02 0.01 0.01 6.0e-02 1.5e-03 2.4e-02 1.6e-02
6 Adipose alternative polyA NM_176861.2 0.05 0.04 2.7e-04 0.01 0.02 0.01 0.01 6.7e-02 1.6e-03 6.9e-02 2.0e-02
7 Adipose alternative polyA NM_176861.2 0.03 0.03 3.1e-03 0 0.01 0.01 0 2.7e-01 1.4e-02 5.4e-02 1.4e-01
8 Adipose alternative polyA XM_039101980.1 0.04 0.03 1.0e-03 0 0.02 0 0.01 9.9e-02 6.5e-03 2.8e-01 4.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.22.05.6-2.4-2.2-0.82.00.4-0.4-0.20.3
Area under the delay curve0.80.81.9-1.0-0.80.11.40.9-0.9-0.80.9
BMI with tail0.72.43.8-0.9-0.41.12.01.9-1.9-1.81.8
BMI without tail1.02.13.9-1.2-0.70.72.01.7-1.6-1.51.6
Body weight0.52.13.40.21.01.80.71.7-1.7-1.71.8
Weight adjusted by age2.12.43.30.50.4-1.7-1.8-1.81.81.7-1.8
Bone surface0.20.40.7-0.8-0.7-0.60.0-0.60.60.6-0.6
Bone volume0.50.91.6-1.2-1.1-1.10.1-0.80.80.9-0.9
Breakpoint value in progressive ratio session1.31.43.7-0.8-1.10.31.91.2-1.2-1.11.1
Number of licking bursts1.72.03.00.2-0.11.21.61.7-1.7-1.71.7
Context. condit. distance diff. score2.32.78.7-3.0-2.7-1.42.0-0.00.10.3-0.2
Locomotion velocity, session 12.83.15.52.12.22.3-0.41.5-1.5-1.61.6
Locomotion distance, session 12.33.05.41.61.82.30.11.7-1.7-1.81.8
Locomotion velocity, session 23.64.18.32.92.92.5-0.81.5-1.5-1.71.6
Locomotion distance, session 21.31.83.71.91.91.7-0.70.9-0.9-1.01.0
Locomotion velocity, session 30.30.40.60.40.60.60.20.7-0.7-0.80.7
Locomotion distance, session 30.50.51.21.11.00.7-0.20.6-0.6-0.70.6
Stereotopy head waving bouts, day 30.00.00.10.20.2-0.3-0.10.0-0.0-0.10.0
Stereotopy head waving duration, day 30.40.41.1-0.7-0.6-0.21.00.6-0.6-0.60.6
Locomotion velocity, session 70.40.41.10.50.7-0.0-1.1-0.60.60.6-0.6
Locomotion distance, session 70.40.51.20.50.5-0.4-1.1-0.80.80.7-0.8
Stereotopy head waving bouts, day 72.42.74.1-0.2-0.11.41.82.0-2.0-2.02.0
Stereotopy head waving duration, day 72.02.43.6-0.5-0.21.31.81.9-1.9-1.81.9
Locomotion velocity, session 81.31.52.9-0.5-0.70.91.71.4-1.4-1.31.4
Locomotion distance, session 80.30.51.6-1.2-1.0-0.31.00.3-0.3-0.20.3
Degree of sensitization distance1.71.72.6-0.1-0.1-1.2-1.3-1.61.61.6-1.6
Degree of sensitization stereotypy2.22.43.6-0.5-0.31.31.91.9-1.9-1.81.8
Conditioned locomotion1.11.32.0-0.9-0.9-1.4-0.4-1.21.21.3-1.3
Cocaine response after cond. corrected0.40.40.6-0.3-0.4-0.8-0.3-0.70.70.7-0.7
Cocaine response after cond. not corrected0.30.30.50.20.2-0.4-0.7-0.60.60.6-0.6
Cocaine response before conditioning0.00.10.10.20.40.3-0.10.2-0.2-0.20.2
Saline control response0.40.50.80.00.3-0.6-0.9-0.80.80.8-0.8
Bone: connectivity density0.71.23.0-1.4-1.3-0.11.70.9-0.9-0.70.8
Bone: cortical apparent density0.20.20.4-0.3-0.5-0.6-0.1-0.50.60.6-0.6
Bone: cortical area1.62.43.7-1.1-1.1-1.9-0.7-1.81.81.8-1.8
Bone: cortical porosity0.20.20.6-0.5-0.4-0.70.1-0.40.40.4-0.4
Bone: cortical porosity0.50.51.0-0.9-0.7-1.0-0.0-0.70.70.7-0.7
Bone: cortical thickness1.42.33.6-1.5-1.5-1.9-0.2-1.51.61.6-1.6
Bone: cortical thickness1.11.31.61.21.11.30.21.2-1.2-1.31.2
Bone: cortical tissue density0.10.20.3-0.3-0.5-0.6-0.1-0.50.50.5-0.5
Condit. Reinf. active minus inactive responses0.70.82.01.41.30.4-1.4-0.50.50.4-0.5
Condit. Reinf. active-inactive response ratio0.90.92.20.90.8-0.2-1.5-1.01.00.9-1.0
Condit. Reinf. active responses0.50.61.71.31.20.6-1.0-0.10.10.0-0.0
Condit. Reinf. inactive responses0.40.50.70.30.40.80.40.8-0.8-0.80.8
Incentive salience index mean0.80.92.51.61.50.7-1.4-0.30.30.2-0.2
Condit. Reinf. lever presses0.50.61.61.01.30.9-0.50.5-0.5-0.60.6
Condit. Reinf. active minus inactive responses0.50.61.70.81.2-0.0-1.3-0.50.50.4-0.4
Condit. Reinf. active-inactive response ratio0.60.61.50.50.8-0.4-1.2-0.80.80.7-0.8
Condit. Reinf. active responses1.11.55.01.72.20.6-1.8-0.20.2-0.0-0.1
Condit. Reinf. inactive responses1.31.64.12.02.01.3-1.00.6-0.6-0.80.7
Condit. Reinf. lever presses0.10.20.60.50.80.1-0.6-0.10.10.0-0.0
Condit. Reinf. lever reinforcers received1.01.44.71.72.20.6-1.8-0.20.20.0-0.1
Conditioned reinforcement - actives0.40.40.50.70.1-0.5-0.7-0.70.70.6-0.7
Conditioned reinforcement - inactives0.10.10.10.2-0.00.3-0.2-0.30.30.2-0.2
Conditioned locomotion0.30.41.91.40.70.7-0.50.0-0.0-0.10.1
Patch foraging indifference point 0 sec0.20.30.9-0.1-0.7-0.10.90.5-0.5-0.50.4
Patch foraging indifference point AUC4.95.68.60.10.62.92.02.8-2.8-2.82.8
Delay disc. indifference point, 0s delay0.20.30.70.30.80.5-0.20.4-0.4-0.50.5
Delay disc. indifference point, 16s delay0.90.92.4-1.3-1.5-1.31.1-0.10.10.2-0.2
Delay disc. indifference point, 2s delay0.40.40.9-1.0-0.60.31.00.6-0.5-0.50.5
Delay disc. indifference point, 24s delay1.31.33.1-1.5-1.8-1.50.8-0.60.60.7-0.7
Delay disc. indifference point, 4s delay0.70.81.2-0.20.00.60.91.1-1.1-1.11.1
Delay disc. indifference point, 8s delay0.50.50.8-0.10.00.30.70.9-0.9-0.90.9
Indifference point function ln k2.94.15.90.1-0.2-2.3-2.0-2.42.42.4-2.4
Indifference point function log k2.94.15.90.1-0.2-2.3-2.0-2.42.42.4-2.4
Patch foraging total patch changes 0 sec0.30.41.1-0.2-0.70.11.10.7-0.7-0.60.6
Patch foraging total patch changes 12 sec1.21.52.3-0.2-0.31.11.51.5-1.5-1.41.5
Patch foraging total patch changes 18 sec1.72.23.20.20.11.61.51.8-1.8-1.81.8
Patch foraging total patch changes 24 sec2.93.57.6-1.3-1.31.12.82.0-2.0-1.91.9
Patch foraging total patch changes 6 sec2.02.96.4-0.9-1.20.92.51.9-1.9-1.81.8
Patch foraging time to switch 0 sec0.40.61.60.0-0.4-1.3-0.5-0.90.90.9-0.9
Patch foraging water rate 0 sec0.20.30.5-0.6-0.30.60.70.6-0.6-0.50.6
Patch foraging water rate 12 sec0.40.71.5-0.2-0.4-1.2-0.5-0.90.90.9-0.9
Patch foraging water rate 18 sec0.30.41.00.91.00.5-0.30.5-0.5-0.60.5
Patch foraging water rate 24 sec0.40.61.5-0.8-0.7-0.01.20.8-0.8-0.70.7
Patch foraging water rate 6 sec0.00.10.10.20.20.00.10.3-0.3-0.30.3
Seeking ratio, delayed vs. immediate footshock1.51.75.8-1.3-1.7-2.40.7-0.80.80.9-0.9
Distance traveled before self-admin0.60.61.7-1.1-1.20.21.30.5-0.5-0.40.4
Distance traveled after self-admin0.20.20.7-0.1-0.20.90.50.5-0.5-0.50.5
Extensor digitorum longus weight0.51.93.40.20.51.81.01.6-1.6-1.61.6
Bone: elastic displacement1.21.42.2-0.5-0.8-1.5-0.6-1.41.41.4-1.4
Bone: elastic work3.24.26.2-0.3-0.6-2.3-1.7-2.52.52.5-2.5
Bone: endosteal estimation0.30.71.50.70.6-0.4-1.2-0.80.80.8-0.8
Bone: endosteal perimeter0.20.51.21.11.10.3-1.1-0.20.20.2-0.2
Epididymis fat weight0.51.13.21.11.81.3-0.70.7-0.7-0.80.8
Delta time in closed arm before/after self-admin0.40.41.1-1.1-0.9-0.40.3-0.40.40.5-0.4
Delta time in open arm before/after self-admin0.40.41.01.01.00.6-0.30.4-0.4-0.50.5
Diff in mean of infusions in LGA sessions0.40.41.1-1.1-0.8-1.00.4-0.30.30.4-0.4
Delay discount exponential model param0.90.92.11.00.9-0.1-1.5-0.90.90.8-0.9
Extinction: sum of active levers before priming1.41.42.3-0.2-0.4-0.9-1.0-1.51.51.5-1.5
Active lever presses in extinction session 60.20.20.40.1-0.6-0.6-0.0-0.50.50.5-0.5
Bone: final force0.61.01.4-0.2-0.1-1.2-1.0-1.21.21.2-1.2
Bone: final moment0.81.32.3-0.5-0.4-1.5-0.9-1.31.31.4-1.3
Food consumed during 24 hour testing period0.00.10.1-0.20.20.10.10.3-0.3-0.30.3
Glucose0.71.12.91.51.30.0-1.7-0.80.80.7-0.7
Heart weight0.30.41.0-1.0-1.0-0.90.7-0.00.00.1-0.1
Delay discount hyperbolic model param0.70.71.71.00.7-0.2-1.3-0.90.80.8-0.8
Intermittent access intake day 1-15 change0.30.31.10.1-0.41.10.70.5-0.5-0.50.5
Intermittent access intake escalation0.60.62.00.2-0.11.40.60.7-0.7-0.70.7
Intermittent access intake escalation 20.30.30.90.80.60.9-0.40.1-0.1-0.10.1
Intermitt. access day 1 inactive lever presses0.20.20.3-0.0-0.2-0.5-0.4-0.60.60.6-0.6
Intermitt. access day 15 inactive lever presses0.60.72.71.70.91.1-0.8-0.00.0-0.10.0
Intermitt. access escalation Index0.00.00.00.00.0-0.20.00.0-0.0-0.00.0
Intermittent access day 1 total infusions1.21.44.02.01.90.4-1.7-0.30.30.1-0.2
Intermittent access day 15 total infusions1.11.22.81.51.11.7-0.10.9-0.9-1.01.0
Intermittent access terminal intake (last 3 days)1.71.84.92.22.01.6-0.90.7-0.7-0.90.8
Intermittent access total infusions1.51.64.72.21.81.5-0.80.7-0.7-0.80.7
Intermittent access day 1 locomotion0.20.30.80.90.90.1-0.6-0.00.0-0.10.0
Intermittent access day 15 total locomotion0.60.61.2-0.1-0.40.61.10.9-0.9-0.90.9
Intermittent access total locomotion1.11.22.31.10.81.50.31.1-1.1-1.21.2
Intermittent access standard deviation0.00.00.20.1-0.20.40.1-0.10.10.1-0.1
Left kidney weight0.10.20.4-0.7-0.3-0.30.60.4-0.4-0.40.4
Right kidney weight0.51.32.0-0.6-0.10.81.31.4-1.4-1.31.4
Cocaine induced anxiety0.60.71.31.01.11.1-0.30.6-0.6-0.70.6
Post-drug Anxiety0.80.93.31.81.41.1-1.00.1-0.1-0.20.2
Baseline Anxiety0.20.20.4-0.1-0.6-0.60.1-0.40.40.4-0.4
Tail length0.00.10.3-0.5-0.1-0.2-0.1-0.30.30.3-0.3
Length with tail0.10.20.70.30.80.4-0.8-0.30.30.2-0.2
Length without tail0.61.32.90.50.8-0.6-1.7-1.31.31.2-1.2
Times rat made contact with spout0.40.51.31.11.10.1-1.1-0.30.30.2-0.2
Lifetime Intake1.41.65.32.32.01.3-1.10.4-0.4-0.60.5
Liver weight, left1.82.85.12.12.32.0-0.51.4-1.4-1.61.5
Liver weight, right0.00.10.20.50.2-0.1-0.3-0.20.20.2-0.2
Locomotor activity1.22.03.90.60.7-0.8-2.0-1.71.71.6-1.6
Locomotor testing distance0.40.61.40.40.6-0.5-1.2-0.90.90.8-0.9
Locomotor testing rearing0.81.21.9-0.7-0.6-1.4-0.7-1.31.31.3-1.3
Locomotion in novel chamber1.51.92.51.11.61.50.11.5-1.5-1.61.5
Locomotion in novel chamber post-restriction0.10.20.5-0.7-0.7-0.10.2-0.20.20.3-0.2
Fecal boli incidents, locomotor time 10.70.71.91.11.0-0.2-1.4-0.70.70.6-0.7
Change in fecal boli incidents, locomotor task0.20.20.6-0.4-0.6-0.10.80.4-0.4-0.30.3
Time >=10cm from walls, locomotor time 10.20.20.6-0.1-0.2-0.8-0.3-0.50.50.5-0.5
Bouts of movement, locomotor time 10.70.71.4-0.8-0.5-1.2-0.4-0.90.91.0-0.9
Total resting periods, locomotor time 10.50.61.2-0.5-0.3-1.1-0.5-0.80.80.8-0.8
Rest time, locomotor task time 10.40.41.51.01.2-0.2-0.80.1-0.1-0.20.2
Distance moved, locomotor task time 11.61.83.3-0.4-0.21.81.41.5-1.5-1.41.5
Vertical activity count, locomotor time 11.51.54.1-0.6-0.32.01.31.3-1.2-1.21.3
Time >=10cm from walls, locomotor time 20.30.31.00.31.00.3-0.20.5-0.5-0.60.5
Bouts of movement, locomotor time 20.40.42.0-0.6-0.5-1.40.2-0.30.30.3-0.3
Total resting periods, locomotor time 20.30.41.9-0.5-0.4-1.40.0-0.40.40.4-0.4
Rest time, locomotor task time 20.60.73.5-0.5-0.5-1.9-0.1-0.60.60.6-0.6
Distance moved, locomotor task time 22.52.99.10.61.13.00.71.7-1.7-1.81.8
Vertical activity count, locomotor time 23.43.710.81.42.03.3-0.11.7-1.7-1.81.8
Light reinforcement 11.52.84.1-0.6-0.6-1.9-1.3-2.02.02.0-2.0
Light reinforcement 20.00.00.10.10.20.3-0.2-0.10.10.0-0.0
Bone: marrow area0.20.41.10.70.6-0.3-1.1-0.70.70.6-0.6
Bone: maximum diameter0.20.30.5-0.3-0.3-0.6-0.4-0.70.70.7-0.7
Bone: maximum force1.12.02.8-0.0-0.1-1.6-1.4-1.71.71.7-1.7
Bone: maximum moment1.52.53.8-0.3-0.3-2.0-1.4-1.91.91.9-1.9
Mean time between licks in bursts1.52.13.20.20.2-1.2-1.7-1.81.81.7-1.7
Mean num. licks in bursts1.31.63.00.40.6-0.8-1.7-1.51.51.4-1.4
Cd content in liver0.60.61.61.31.30.7-1.1-0.20.20.1-0.1
Co content in liver1.61.93.61.31.51.90.01.3-1.3-1.41.4
Cu content in liver0.20.20.50.60.4-0.0-0.7-0.50.50.4-0.4
Fe content in liver0.70.81.20.50.0-0.8-1.0-1.11.11.1-1.1
K content in liver1.01.02.3-1.5-1.4-1.10.4-0.70.70.8-0.8
Mg content in liver1.71.82.8-1.7-1.4-1.6-0.1-1.31.31.4-1.3
Mn content in liver2.22.55.1-1.5-1.4-2.3-0.3-1.61.61.7-1.6
Na content in liver1.01.02.3-0.9-0.80.51.51.1-1.1-1.01.0
Rb content in liver0.91.22.1-1.2-1.5-1.40.3-0.90.91.0-1.0
Se content in liver0.30.41.31.11.00.4-0.9-0.10.1-0.0-0.0
Sr content in liver1.81.72.50.80.71.40.81.5-1.5-1.61.5
Zn content in liver0.50.50.8-0.1-0.3-0.7-0.6-0.90.90.9-0.9
Bone: minimum diameter1.93.55.3-0.1-0.2-1.8-1.9-2.32.32.3-2.3
Time in familiar zone, hab. session 10.70.72.00.70.61.40.20.8-0.8-0.80.8
Time in novel zone, hab. session 11.41.43.2-1.8-1.8-1.60.9-0.50.50.7-0.6
Total zone transitions, hab. session 10.60.81.1-0.3-0.11.01.01.0-1.0-1.01.0
Total locomotion distance, hab. session 10.81.22.9-1.7-1.60.01.70.6-0.6-0.50.6
Locomotion velocity, hab. session 10.81.12.7-1.6-1.50.01.60.6-0.6-0.50.6
Time in familiar zone, hab. session 20.10.10.2-0.0-0.1-0.2-0.3-0.40.40.4-0.4
Time in novel zone, hab. session 20.50.51.3-1.2-1.1-0.80.90.0-0.00.0-0.0
Total zone transitions, hab. session 20.50.71.01.00.80.90.10.9-0.9-0.90.9
Total locomotion distance, hab. session 20.20.20.40.2-0.00.40.50.6-0.6-0.60.6
Locomotion velocity, hab. session 20.20.30.50.50.30.60.40.7-0.7-0.70.7
Novel to familiar place preference ratio3.13.28.7-2.9-2.9-0.92.70.5-0.5-0.20.4
Novelty place preference3.94.011.0-3.2-3.3-1.12.90.5-0.5-0.20.4
Time in novel zone, NPP test4.44.513.0-3.5-3.6-1.23.00.4-0.4-0.10.2
Total zone transitions, NPP test1.92.74.82.12.22.1-0.51.3-1.3-1.51.4
Total locomotion distance, NPP test1.01.32.41.51.41.5-0.21.0-1.0-1.01.0
Locomotion velocity, NPP test1.01.42.81.71.61.4-0.50.9-0.9-1.00.9
Intraocular pressure0.20.30.70.40.6-0.6-0.9-0.50.50.4-0.5
Delta distance traveled before/after self-admin0.40.41.31.11.00.4-0.8-0.10.1-0.0-0.0
Delta ambulatory time before/after self-admin0.20.20.90.90.60.2-0.5-0.10.10.0-0.1
Parametrial fat weight0.30.61.30.20.71.10.20.8-0.8-0.80.9
Pavlov. Cond. lever latency1.51.94.4-1.8-2.1-1.60.7-1.01.01.1-1.1
Pavlov. Cond. magazine entry latency0.40.61.10.00.31.10.50.9-0.9-0.80.9
Pavlov. Cond. change in total contacts1.81.93.91.21.52.00.01.3-1.3-1.41.4
Pavlov. Cond. index score3.13.97.11.51.92.70.42.1-2.1-2.22.2
Pavlov. Cond. latency score2.63.35.91.62.12.4-0.11.7-1.7-1.91.8
Pavlov. Cond. lever contacts1.71.94.21.72.11.8-0.61.0-1.1-1.21.1
Pavlov. Cond. magazine entry number3.24.06.8-0.7-1.0-2.6-1.2-2.42.42.4-2.4
Pavlov. Cond. intertrial magazine entries0.50.60.90.30.2-0.6-0.9-0.90.90.9-0.9
Pavlov. Cond. lever-magazine prob. diff.2.83.56.21.31.62.50.52.0-2.0-2.12.1
Pavlov. Cond. response bias2.73.35.50.81.12.31.02.1-2.1-2.12.2
Pavlov. Cond. lever latency0.60.91.3-0.5-0.6-1.0-0.5-1.11.11.1-1.1
Pavlov. Cond. magazine entry latency0.70.81.30.70.71.10.31.0-1.0-1.01.0
Pavlov. Cond. change in total contacts1.01.32.91.71.71.4-0.60.8-0.8-0.90.8
Pavlov. Cond. index score1.21.52.40.91.01.60.41.4-1.4-1.41.4
Pavlov. Cond. latency score1.31.72.71.01.11.70.41.4-1.4-1.51.4
Pavlov. Cond. lever contacts0.30.40.60.10.10.60.70.8-0.8-0.80.8
Pavlov. Cond. magazine entry number1.31.62.3-0.6-0.5-1.5-0.9-1.51.51.5-1.5
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.2-0.0-0.4-0.4-0.40.40.4-0.4
Pavlov. Cond. lever-magazine prob. diff.1.41.83.01.11.21.70.41.5-1.5-1.51.5
Pavlov. Cond. response bias0.30.40.60.30.20.70.50.8-0.8-0.80.8
Time in closed arm before self-admin0.10.20.4-0.3-0.6-0.40.2-0.40.40.4-0.4
Time in closed arm after self-admin0.80.81.3-0.8-1.0-0.8-0.2-1.01.11.1-1.1
Time in open arm before self-admin0.80.91.9-1.3-0.80.11.40.9-0.8-0.80.8
Time in open arm after self-admin0.70.81.3-0.10.50.50.71.1-1.1-1.21.1
Bone: periosteal estimation0.71.52.3-0.1-0.2-1.3-1.2-1.51.51.5-1.5
Bone: periosteal perimeter0.71.11.6-0.1-0.2-1.1-1.0-1.31.31.3-1.3
Bone: post-yield work1.11.44.82.21.91.0-1.30.2-0.2-0.40.3
Progressive ratio test 1 active lever presses0.40.51.11.01.10.2-1.1-0.30.30.2-0.2
Progressive ratio test 1 breakpoint0.50.51.31.11.10.2-1.1-0.30.30.2-0.3
Progressive ratio test 1 inactive lever presses0.50.51.71.30.80.4-1.0-0.40.40.3-0.3
Progressive ratio test 2 active lever presses1.51.62.91.61.41.7-0.11.1-1.1-1.21.2
Progressive ratio test 2 breakpoint1.41.62.61.51.21.60.21.2-1.2-1.31.2
Progressive ratio test 2 inactive lever presses1.11.23.31.81.31.5-0.40.7-0.7-0.80.8
Incentive Sensitization - Responses1.71.82.91.00.71.70.71.5-1.5-1.51.5
Incentive Sensitization - Breakpoint1.91.93.31.30.91.80.61.5-1.5-1.51.5
Sum of active levers in priming session hrs 5-61.00.92.21.41.1-0.2-1.5-0.80.80.6-0.7
Progressive ratio0.00.10.10.30.3-0.2-0.3-0.10.10.1-0.1
Food seeking constrained by brief footshock0.60.81.6-1.2-1.1-1.30.3-0.60.60.7-0.6
Seeking ratio, punishment vs. effort0.30.41.3-1.0-1.1-0.30.7-0.10.10.2-0.1
Retroperitoneal fat weight0.00.10.70.20.80.1-0.6-0.0-0.0-0.00.0
Reaction time number correct1.92.76.92.52.61.7-1.11.0-1.0-1.21.1
Reaction time mean minus median0.20.20.30.10.50.60.20.6-0.6-0.60.6
Reaction time mean minus median AUC0.40.60.9-0.20.20.70.70.9-0.9-0.90.9
Reaction time num false alarms0.00.00.0-0.2-0.1-0.10.20.1-0.1-0.10.1
Reaction time num false alarms AUC0.00.10.10.20.20.30.10.3-0.3-0.30.3
Reaction time trials correct on left1.92.76.92.52.61.7-1.11.0-1.0-1.21.1
Reaction time trials on left1.92.76.92.52.61.6-1.20.9-0.9-1.11.0
Reaction time mean0.60.82.11.41.30.1-1.4-0.60.60.4-0.5
Reaction time mean AUC0.50.71.71.21.0-0.1-1.3-0.70.70.6-0.6
Median of all reaction times0.70.92.21.41.1-0.1-1.5-0.70.70.6-0.7
Reaction time omissions1.21.62.5-0.3-0.2-1.2-1.2-1.61.61.6-1.6
Reaction time false alarm rate0.40.51.5-1.2-1.2-0.60.8-0.20.20.3-0.2
Reaction time premature initiation rate0.30.41.2-1.1-1.1-0.60.7-0.10.10.2-0.2
Reaction time premature initiations0.10.20.30.50.50.3-0.10.4-0.4-0.40.4
Std. dev. reaction times0.10.20.40.50.70.6-0.20.3-0.3-0.40.3
Reaction time trials completed1.92.76.92.52.61.6-1.20.9-0.9-1.11.0
Reaction time trials AUC1.72.46.52.42.51.5-1.20.8-0.8-1.00.9
Run reversals in cocaine runway, females0.00.00.10.2-0.20.30.30.2-0.2-0.10.1
Run reversals in cocaine runway, males0.30.30.70.80.70.8-0.50.1-0.1-0.20.2
Latency to leave start box in cocaine runway0.10.10.20.10.50.0-0.00.3-0.3-0.30.3
Latency to leave start box in cocaine runway, F0.20.20.4-0.00.60.10.10.5-0.5-0.50.5
Latency to leave start box in cocaine runway, M0.20.20.3-0.1-0.4-0.5-0.2-0.60.60.6-0.6
Std. dev. time between licks in bursts0.20.20.80.30.90.1-0.9-0.30.20.2-0.2
Total sessions with >9 infusions1.21.32.10.50.4-1.1-1.4-1.31.31.2-1.3
Short access day 1 total inactive lever presses0.50.61.00.3-0.50.71.00.8-0.8-0.80.8
Short access day 10 total inactive lever presses0.60.71.6-0.7-0.80.71.20.8-0.8-0.70.8
Short access day 1 total infusions0.40.41.61.31.00.2-0.8-0.10.0-0.0-0.0
Short access day 10 total infusions0.60.72.11.51.30.4-1.1-0.10.1-0.0-0.0
Short access total infusions0.80.93.11.81.50.4-1.3-0.20.20.1-0.1
Short access day 1 locomotion0.60.61.00.1-0.10.41.01.0-1.0-1.01.0
Short access day 10 total locomotion0.30.40.7-0.3-0.40.60.80.7-0.7-0.60.6
Short access total locomotion0.20.20.70.80.6-0.1-0.30.2-0.2-0.30.2
One hour access (0.3 mA shock)0.91.02.21.51.31.5-0.50.6-0.6-0.70.7
Compulsive drug intake0.20.20.50.20.60.0-0.7-0.30.30.3-0.3
One hour access (shock baseline)1.31.53.41.81.61.5-0.50.8-0.8-1.00.9
Social response proportion1.51.63.81.11.2-0.8-2.0-1.31.31.1-1.2
Social responses0.00.00.1-0.2-0.1-0.30.20.1-0.1-0.10.1
Social time2.63.45.50.90.7-1.7-2.3-2.12.12.0-2.1
Soleus weight3.811.232.0-5.7-5.2-1.34.91.2-1.2-0.71.0
Bone: stiffness0.50.81.3-0.1-0.2-1.1-0.8-1.11.11.1-1.1
Tibialis anterior weight0.41.21.8-0.3-0.21.11.31.3-1.3-1.31.3
Time to tail flick, vehicle, before self-admin0.60.61.30.30.6-0.6-1.2-0.90.90.8-0.8
Time to tail flick, vehicle, after self-admin0.91.03.01.71.40.6-1.4-0.40.40.3-0.4
Time to tail flick, test, before self-admin1.71.73.9-1.9-2.0-1.70.9-0.70.70.8-0.7
Time to tail flick, test, after self-admin1.61.64.6-2.1-1.8-0.81.90.6-0.6-0.40.5
Delta time to tail flick, vehicle, before/after SA0.60.62.01.41.11.0-0.9-0.00.0-0.00.0
Delta time to tail flick, test, before/after SA2.11.92.9-0.7-0.21.01.71.7-1.7-1.61.6
Tibia length1.64.612.12.22.2-0.2-3.5-2.12.01.9-1.9
Ambulatory time before self-admin0.40.41.5-1.1-1.2-0.10.8-0.10.10.2-0.1
Ambulatory time after self-admin0.00.00.2-0.1-0.40.00.2-0.10.10.1-0.1
Bone: tissue strength7.06.89.9-1.7-1.5-2.9-1.5-3.13.13.1-3.1
Total heroin consumption1.92.36.0-1.9-2.4-0.92.50.7-0.7-0.50.6
Bone: trabecular number2.84.511.3-2.4-2.30.33.41.9-1.9-1.71.8
Bone: trabecular spacing2.43.27.31.51.4-0.8-2.7-1.91.91.7-1.8
Bone: trabecular thickness0.20.20.7-0.9-0.7-0.60.5-0.10.10.1-0.1
Bone: trabecular tissue density0.30.41.10.50.5-0.1-1.0-0.70.70.7-0.7
Water consumed over 24 hours0.00.00.1-0.00.0-0.3-0.1-0.20.20.2-0.2
Number of responses in last shaping day1.41.52.40.30.20.81.21.5-1.5-1.61.5