Hub : Genes

Kcnmb2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Kcnmb2 0.05 0.04 1.2e-03 0.04 0.03 0.04 0.04 1.0e-04 8.9e-04 1.9e-04 2.6e-04
2 BLA mRNA stability Kcnmb2 0.07 0.05 3.1e-03 0 0.02 0.01 0.01 2.1e-01 4.5e-02 7.9e-02 1.5e-01
3 PL gene expression Kcnmb2 0.03 0.02 2.3e-04 0.03 0.03 0.03 0.03 7.6e-04 5.3e-04 7.8e-04 5.3e-04
4 Adipose gene expression Kcnmb2 0.06 0.04 2.7e-05 0.02 0.03 0.03 0.02 4.4e-03 7.1e-04 6.4e-04 1.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density2.23.85.8-2.4-2.41.90.2
Area under the delay curve1.31.52.5-1.2-0.91.6-1.2
BMI with tail0.61.94.5-0.9-0.41.5-2.1
BMI without tail0.51.42.1-1.0-0.71.5-1.4
Body weight0.31.12.5-0.4-0.21.3-1.6
Weight adjusted by age1.42.24.60.40.7-1.92.1
Bone surface0.20.30.9-0.3-0.6-0.10.9
Bone volume0.40.71.9-0.5-0.9-0.11.4
Breakpoint value in progressive ratio session1.51.82.6-1.4-1.51.6-0.8
Number of licking bursts0.81.23.10.1-0.51.3-1.8
Context. condit. distance diff. score4.25.18.0-2.6-2.82.30.5
Locomotion velocity, session 11.92.03.61.21.9-1.0-1.4
Locomotion distance, session 11.11.43.00.61.4-0.4-1.7
Locomotion velocity, session 23.03.56.71.72.6-1.6-1.4
Locomotion distance, session 21.21.73.31.21.8-1.2-0.8
Locomotion velocity, session 30.00.10.10.00.3-0.2-0.3
Locomotion distance, session 30.40.40.80.60.9-0.6-0.5
Stereotopy head waving bouts, day 30.10.10.20.10.1-0.40.3
Stereotopy head waving duration, day 30.50.61.0-1.0-0.90.8-0.3
Locomotion velocity, session 70.80.81.30.90.8-1.10.8
Locomotion distance, session 70.81.01.51.00.8-1.21.0
Stereotopy head waving bouts, day 70.91.12.6-0.8-0.11.0-1.6
Stereotopy head waving duration, day 71.51.82.6-1.3-0.71.5-1.6
Locomotion velocity, session 81.61.92.6-1.6-1.01.4-1.4
Locomotion distance, session 80.60.91.5-1.2-1.10.90.1
Degree of sensitization distance1.31.33.20.90.3-1.11.8
Degree of sensitization stereotypy2.22.43.6-1.5-0.81.8-1.9
Conditioned locomotion0.50.61.8-0.1-0.6-0.21.3
Cocaine response after cond. corrected0.10.10.4-0.1-0.2-0.10.6
Cocaine response after cond. not corrected0.30.30.50.50.4-0.60.7
Cocaine response before conditioning0.00.00.00.10.2-0.20.1
Saline control response0.20.20.70.40.0-0.40.8
Bone: connectivity density1.21.92.8-1.7-1.61.6-0.3
Bone: cortical apparent density0.20.30.7-0.3-0.5-0.20.9
Bone: cortical area0.91.44.70.1-0.7-0.62.2
Bone: cortical porosity0.10.10.2-0.2-0.50.40.3
Bone: cortical porosity0.20.20.4-0.2-0.60.40.5
Bone: cortical thickness0.81.33.6-0.5-1.10.01.9
Bone: cortical thickness0.30.40.80.40.7-0.2-0.9
Bone: cortical tissue density0.20.20.6-0.3-0.5-0.20.8
Condit. Reinf. active minus inactive responses1.31.42.21.51.5-1.2-0.0
Condit. Reinf. active-inactive response ratio0.91.01.41.21.1-1.00.5
Condit. Reinf. active responses0.81.01.81.11.3-1.0-0.3
Condit. Reinf. inactive responses0.10.10.5-0.10.2-0.0-0.7
Incentive salience index mean1.51.82.91.61.7-1.3-0.2
Condit. Reinf. lever presses0.71.01.51.11.2-0.7-0.8
Condit. Reinf. active minus inactive responses0.60.81.11.11.1-0.90.3
Condit. Reinf. active-inactive response ratio0.50.50.90.90.7-0.70.6
Condit. Reinf. active responses2.12.94.31.92.1-1.90.3
Condit. Reinf. inactive responses1.62.13.71.41.9-1.6-0.5
Condit. Reinf. lever presses0.30.40.60.60.8-0.7-0.0
Condit. Reinf. lever reinforcers received1.92.73.91.82.0-1.90.3
Conditioned reinforcement - actives0.40.71.31.10.6-0.90.3
Conditioned reinforcement - inactives0.10.10.30.10.2-0.60.3
Conditioned locomotion0.40.50.70.70.9-0.7-0.4
Patch foraging indifference point 0 sec0.40.81.4-1.2-0.80.7-0.6
Patch foraging indifference point AUC1.82.65.6-1.5-0.31.5-2.4
Delay disc. indifference point, 0s delay0.20.20.50.40.7-0.2-0.4
Delay disc. indifference point, 16s delay1.51.72.4-1.5-1.61.5-0.2
Delay disc. indifference point, 2s delay0.91.01.6-1.0-0.81.3-0.9
Delay disc. indifference point, 24s delay1.21.42.5-1.3-1.61.10.2
Delay disc. indifference point, 4s delay0.80.81.9-0.5-0.31.0-1.4
Delay disc. indifference point, 8s delay0.50.61.6-0.5-0.10.9-1.2
Indifference point function ln k1.01.73.21.30.4-1.31.8
Indifference point function log k1.01.73.21.30.4-1.31.8
Patch foraging total patch changes 0 sec0.40.71.3-1.1-0.70.7-0.7
Patch foraging total patch changes 12 sec0.70.91.6-1.1-0.40.9-1.3
Patch foraging total patch changes 18 sec0.81.23.0-1.1-0.10.8-1.7
Patch foraging total patch changes 24 sec2.23.75.1-2.3-1.62.1-1.7
Patch foraging total patch changes 6 sec2.23.46.3-2.5-1.51.7-1.5
Patch foraging time to switch 0 sec0.10.20.80.3-0.1-0.30.9
Patch foraging water rate 0 sec0.10.20.5-0.7-0.50.4-0.3
Patch foraging water rate 12 sec0.20.51.50.1-0.3-0.51.2
Patch foraging water rate 18 sec0.40.60.90.90.9-0.9-0.1
Patch foraging water rate 24 sec0.60.91.4-1.2-1.01.0-0.3
Patch foraging water rate 6 sec0.00.00.00.1-0.0-0.10.0
Seeking ratio, delayed vs. immediate footshock1.41.72.7-1.2-1.60.91.4
Distance traveled before self-admin1.41.82.9-1.7-1.01.5-1.1
Distance traveled after self-admin0.30.41.0-0.5-0.00.4-1.0
Extensor digitorum longus weight0.31.33.7-0.30.11.2-1.9
Bone: elastic displacement0.20.30.8-0.1-0.60.00.9
Bone: elastic work1.52.05.30.8-0.0-1.42.3
Bone: endosteal estimation0.40.91.41.10.8-1.20.6
Bone: endosteal perimeter0.61.21.81.31.2-1.30.4
Epididymis fat weight0.10.50.90.50.90.0-0.9
Delta time in closed arm before/after self-admin1.41.32.0-1.1-1.41.4-0.1
Delta time in open arm before/after self-admin0.30.30.50.40.7-0.2-0.6
Diff in mean of infusions in LGA sessions0.30.40.8-0.9-0.60.20.5
Delay discount exponential model param1.61.82.91.21.0-1.71.3
Extinction: sum of active levers before priming0.80.81.50.80.6-1.01.2
Active lever presses in extinction session 60.20.20.50.1-0.60.7-0.2
Bone: final force0.40.61.60.60.1-0.71.3
Bone: final moment0.40.72.10.4-0.2-0.51.5
Food consumed during 24 hour testing period0.10.10.20.5-0.00.4-0.2
Glucose1.01.62.51.31.3-1.60.6
Heart weight0.10.20.4-0.3-0.10.6-0.7
Delay discount hyperbolic model param1.61.72.81.20.9-1.71.4
Intermittent access intake day 1-15 change0.20.40.5-0.5-0.70.7-0.5
Intermittent access intake escalation0.20.50.7-0.5-0.70.7-0.8
Intermittent access intake escalation 20.00.00.10.2-0.1-0.20.3
Intermitt. access day 1 inactive lever presses0.10.30.80.1-0.3-0.40.9
Intermitt. access day 15 inactive lever presses0.30.71.50.41.1-1.2-0.1
Intermitt. access escalation Index0.20.30.9-0.4-0.60.00.9
Intermittent access day 1 total infusions3.15.06.72.52.5-2.60.7
Intermittent access day 15 total infusions0.30.50.60.70.7-0.5-0.7
Intermittent access terminal intake (last 3 days)1.21.62.31.51.4-1.50.3
Intermittent access total infusions1.41.72.51.51.6-1.3-0.5
Intermittent access day 1 locomotion1.52.02.71.61.6-1.60.4
Intermittent access day 15 total locomotion0.10.20.6-0.20.00.2-0.8
Intermittent access total locomotion0.40.51.10.60.8-0.3-1.0
Intermittent access standard deviation0.10.10.3-0.5-0.40.2-0.0
Left kidney weight0.10.61.3-0.5-0.80.21.2
Right kidney weight0.42.02.9-1.7-1.31.7-0.7
Cocaine induced anxiety0.60.91.61.31.1-0.3-0.9
Post-drug Anxiety0.70.71.21.11.0-0.5-0.6
Baseline Anxiety0.00.10.2-0.40.0-0.20.1
Tail length0.00.00.10.10.20.3-0.2
Length with tail0.10.41.01.00.8-0.30.0
Length without tail0.10.20.30.50.40.2-0.6
Times rat made contact with spout1.11.22.31.51.2-1.10.1
Lifetime Intake1.92.33.41.71.8-1.7-0.3
Liver weight, left1.72.84.82.02.2-1.4-0.8
Liver weight, right0.50.91.60.70.3-1.21.3
Locomotor activity1.42.23.11.81.0-1.61.4
Locomotor testing distance0.71.21.91.41.1-1.10.7
Locomotor testing rearing0.30.51.80.3-0.3-0.41.3
Locomotion in novel chamber1.01.32.11.21.2-0.2-1.5
Locomotion in novel chamber post-restriction0.00.10.2-0.2-0.40.20.1
Fecal boli incidents, locomotor time 10.91.31.91.41.2-1.30.5
Change in fecal boli incidents, locomotor task0.40.40.7-0.8-0.60.8-0.3
Time >=10cm from walls, locomotor time 10.10.10.20.2-0.1-0.10.5
Bouts of movement, locomotor time 10.70.82.60.3-0.5-0.41.6
Total resting periods, locomotor time 10.60.72.00.5-0.2-0.51.4
Rest time, locomotor task time 10.50.61.10.91.1-0.80.2
Distance moved, locomotor task time 10.91.33.0-0.9-0.51.1-1.7
Vertical activity count, locomotor time 10.61.52.9-1.0-0.61.3-1.7
Time >=10cm from walls, locomotor time 20.10.10.30.30.50.1-0.2
Bouts of movement, locomotor time 20.30.51.5-0.5-0.6-0.21.2
Total resting periods, locomotor time 20.30.51.5-0.5-0.4-0.41.2
Rest time, locomotor task time 20.30.41.1-0.4-0.50.01.0
Distance moved, locomotor task time 21.21.44.70.20.80.5-2.2
Vertical activity count, locomotor time 21.52.15.00.71.6-0.1-2.2
Light reinforcement 10.41.02.70.8-0.0-0.71.6
Light reinforcement 20.10.10.20.50.4-0.1-0.2
Bone: marrow area0.30.71.00.90.8-1.00.5
Bone: maximum diameter0.20.51.40.1-0.1-0.61.2
Bone: maximum force0.91.63.41.00.4-1.31.8
Bone: maximum moment0.91.54.10.80.1-1.22.0
Mean time between licks in bursts0.61.52.70.20.8-1.61.6
Mean num. licks in bursts0.81.32.10.41.0-1.51.3
Cd content in liver2.32.54.31.22.0-2.10.4
Co content in liver0.40.51.00.60.8-0.1-1.0
Cu content in liver0.30.30.70.50.5-0.80.3
Fe content in liver0.30.30.50.70.3-0.60.6
K content in liver1.31.22.2-0.5-1.50.41.5
Mg content in liver1.31.32.9-0.4-1.40.41.7
Mn content in liver0.60.71.70.5-0.90.11.3
Na content in liver0.40.40.6-0.6-0.60.8-0.5
Rb content in liver0.80.91.8-0.9-1.30.80.7
Se content in liver0.70.81.21.10.8-1.10.6
Sr content in liver0.60.51.7-0.00.30.6-1.3
Zn content in liver0.20.20.40.70.3-0.50.1
Bone: minimum diameter1.22.14.91.20.3-1.42.2
Time in familiar zone, hab. session 10.30.30.90.30.50.1-0.9
Time in novel zone, hab. session 11.91.93.1-1.7-1.81.00.8
Total zone transitions, hab. session 10.60.81.5-0.9-0.30.9-1.2
Total locomotion distance, hab. session 12.02.84.8-2.2-1.71.8-0.7
Locomotion velocity, hab. session 11.82.64.0-2.0-1.61.8-0.8
Time in familiar zone, hab. session 20.20.20.40.50.0-0.50.6
Time in novel zone, hab. session 21.41.42.2-1.5-1.31.4-0.2
Total zone transitions, hab. session 20.20.30.50.00.6-0.3-0.7
Total locomotion distance, hab. session 20.10.20.3-0.5-0.10.4-0.6
Locomotion velocity, hab. session 20.10.10.4-0.20.20.1-0.6
Novel to familiar place preference ratio6.87.510.3-3.2-3.23.0-0.5
Novelty place preference8.69.213.0-3.6-3.53.3-0.5
Time in novel zone, NPP test9.510.214.5-3.8-3.83.5-0.4
Total zone transitions, NPP test1.42.13.91.22.0-1.1-1.3
Total locomotion distance, NPP test0.70.91.60.81.2-0.8-0.9
Locomotion velocity, NPP test0.91.32.21.11.5-1.1-0.7
Intraocular pressure0.50.71.81.30.6-0.60.5
Delta distance traveled before/after self-admin0.60.60.90.90.9-0.90.0
Delta ambulatory time before/after self-admin0.20.20.40.70.5-0.5-0.2
Parametrial fat weight0.30.71.11.01.0-0.5-0.5
Pavlov. Cond. lever latency1.62.03.3-1.6-1.80.81.3
Pavlov. Cond. magazine entry latency0.50.61.90.40.40.4-1.4
Pavlov. Cond. change in total contacts1.01.11.90.81.3-0.4-1.4
Pavlov. Cond. index score1.62.04.91.11.4-0.0-2.2
Pavlov. Cond. latency score1.72.23.31.51.7-0.4-1.8
Pavlov. Cond. lever contacts1.61.93.31.61.8-0.9-1.1
Pavlov. Cond. magazine entry number1.41.86.0-0.2-0.5-0.92.4
Pavlov. Cond. intertrial magazine entries0.30.40.80.10.4-0.90.8
Pavlov. Cond. lever-magazine prob. diff.1.41.74.40.91.20.1-2.1
Pavlov. Cond. response bias1.31.65.20.40.70.7-2.3
Pavlov. Cond. lever latency0.10.20.60.4-0.1-0.20.8
Pavlov. Cond. magazine entry latency0.30.31.10.00.5-0.1-1.0
Pavlov. Cond. change in total contacts0.71.02.00.81.4-0.9-0.8
Pavlov. Cond. index score0.40.51.70.00.7-0.1-1.3
Pavlov. Cond. latency score0.50.71.90.20.8-0.1-1.4
Pavlov. Cond. lever contacts0.10.20.4-0.5-0.10.2-0.6
Pavlov. Cond. magazine entry number0.50.62.10.4-0.2-0.41.5
Pavlov. Cond. intertrial magazine entries0.00.10.20.10.0-0.20.4
Pavlov. Cond. lever-magazine prob. diff.0.50.61.80.10.8-0.1-1.4
Pavlov. Cond. response bias0.10.10.4-0.30.1-0.0-0.6
Time in closed arm before self-admin0.30.40.6-0.6-0.80.10.7
Time in closed arm after self-admin0.70.71.5-0.6-1.20.50.8
Time in open arm before self-admin0.80.91.3-1.1-0.71.2-0.7
Time in open arm after self-admin0.40.40.9-0.40.10.7-1.0
Bone: periosteal estimation0.51.12.60.80.2-1.11.6
Bone: periosteal perimeter0.71.13.00.60.1-1.11.7
Bone: post-yield work1.31.83.11.61.7-1.3-0.4
Progressive ratio test 1 active lever presses1.62.02.71.71.6-1.60.3
Progressive ratio test 1 breakpoint1.82.23.11.71.7-1.70.4
Progressive ratio test 1 inactive lever presses1.21.72.61.61.3-1.50.2
Progressive ratio test 2 active lever presses1.21.43.20.71.4-0.4-1.8
Progressive ratio test 2 breakpoint1.11.33.10.61.3-0.3-1.8
Progressive ratio test 2 inactive lever presses0.30.40.80.30.9-0.7-0.7
Incentive Sensitization - Responses0.60.82.60.10.90.1-1.6
Incentive Sensitization - Breakpoint0.70.92.90.10.90.1-1.7
Sum of active levers in priming session hrs 5-61.11.01.51.21.2-1.00.1
Progressive ratio0.10.10.2-0.3-0.50.30.2
Food seeking constrained by brief footshock0.70.81.5-0.7-1.21.00.4
Seeking ratio, punishment vs. effort0.40.60.9-0.8-0.81.0-0.4
Retroperitoneal fat weight0.10.51.20.50.60.3-1.1
Reaction time number correct1.83.55.62.42.3-1.7-0.7
Reaction time mean minus median0.20.51.4-0.00.30.6-1.2
Reaction time mean minus median AUC0.30.81.8-0.5-0.00.9-1.4
Reaction time num false alarms0.00.00.1-0.1-0.20.3-0.1
Reaction time num false alarms AUC0.00.00.00.10.2-0.1-0.2
Reaction time trials correct on left1.83.55.62.42.3-1.7-0.7
Reaction time trials on left1.93.65.82.42.3-1.7-0.6
Reaction time mean0.91.42.41.51.5-0.9-0.2
Reaction time mean AUC0.71.11.91.41.3-0.8-0.2
Median of all reaction times1.01.52.51.61.5-1.10.1
Reaction time omissions0.71.01.71.30.7-0.91.0
Reaction time false alarm rate0.71.01.9-1.4-1.20.90.1
Reaction time premature initiation rate0.60.81.4-1.2-1.10.30.6
Reaction time premature initiations0.10.20.40.20.3-0.70.2
Std. dev. reaction times0.30.51.40.40.70.4-1.2
Reaction time trials completed1.93.65.82.42.3-1.7-0.6
Reaction time trials AUC1.83.45.52.32.2-1.7-0.5
Run reversals in cocaine runway, females0.00.00.1-0.2-0.2-0.2-0.1
Run reversals in cocaine runway, males0.50.50.90.61.0-0.4-0.9
Latency to leave start box in cocaine runway0.20.20.60.80.4-0.30.1
Latency to leave start box in cocaine runway, F0.10.20.50.70.2-0.2-0.0
Latency to leave start box in cocaine runway, M0.10.10.10.30.1-0.20.3
Std. dev. time between licks in bursts0.30.40.80.20.8-0.90.5
Total sessions with >9 infusions3.13.85.72.21.8-2.41.2
Short access day 1 total inactive lever presses0.81.12.8-1.7-0.90.7-0.5
Short access day 10 total inactive lever presses1.43.45.6-2.4-2.02.0-0.6
Short access day 1 total infusions1.11.42.81.01.2-1.70.6
Short access day 10 total infusions2.73.55.42.32.0-2.10.4
Short access total infusions3.03.85.52.12.2-2.40.5
Short access day 1 locomotion0.10.10.10.30.3-0.2-0.3
Short access day 10 total locomotion0.00.00.00.1-0.10.2-0.0
Short access total locomotion0.91.11.61.21.1-1.30.4
One hour access (0.3 mA shock)0.70.81.31.00.9-0.2-1.1
Compulsive drug intake0.20.20.50.70.5-0.3-0.1
One hour access (shock baseline)0.50.81.21.01.1-0.7-0.7
Social response proportion1.82.12.61.61.4-1.61.1
Social responses0.00.00.1-0.3-0.20.2-0.0
Social time2.43.34.22.01.2-2.02.0
Soleus weight8.324.433.9-5.8-5.85.5-0.6
Bone: stiffness0.40.71.90.60.1-0.81.4
Tibialis anterior weight0.41.22.4-0.7-0.41.4-1.6
Time to tail flick, vehicle, before self-admin1.81.92.51.61.2-1.61.0
Time to tail flick, vehicle, after self-admin1.21.62.71.71.6-1.0-0.5
Time to tail flick, test, before self-admin2.32.33.8-2.0-1.71.6-0.0
Time to tail flick, test, after self-admin3.43.55.1-2.0-2.22.3-0.4
Delta time to tail flick, vehicle, before/after SA0.40.40.70.60.9-0.4-0.5
Delta time to tail flick, test, before/after SA0.80.81.5-0.6-0.81.2-0.8
Tibia length3.28.813.23.22.8-3.62.0
Ambulatory time before self-admin0.50.81.6-1.3-0.80.8-0.3
Ambulatory time after self-admin0.00.00.1-0.3-0.10.0-0.0
Bone: tissue strength2.72.89.70.3-0.6-1.03.1
Total heroin consumption3.84.56.7-2.5-2.62.2-0.3
Bone: trabecular number5.08.311.1-3.3-3.03.3-1.4
Bone: trabecular spacing3.74.97.42.32.0-2.71.8
Bone: trabecular thickness0.30.40.7-0.7-0.90.40.5
Bone: trabecular tissue density0.60.91.60.90.8-1.30.8
Water consumed over 24 hours0.10.20.60.80.3-0.1-0.2
Number of responses in last shaping day0.10.10.40.10.00.1-0.6