Hub : Genes

Kcnj16

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA alternative polyA NM_053314.3 0.04 0.02 1.8e-04 0.04 0.05 0.04 0.04 1.7e-04 1.1e-04 6.4e-04 2.1e-04
2 pVTA isoform ratio NM_053314.3 0.16 0.06 0.0e+00 0.21 0.22 0.2 0.22 4.5e-17 2.7e-17 2.6e-16 6.7e-18
3 pVTA alternative polyA XM_006247570.4 0.04 0.02 9.1e-05 0.04 0.05 0.04 0.04 2.5e-04 7.0e-05 8.3e-04 2.5e-04
4 pVTA gene expression Kcnj16 0.27 0.08 0.0e+00 0.41 0.43 0.44 0.44 8.5e-35 6.4e-38 1.9e-38 1.3e-38
5 pVTA isoform ratio XM_006247570.4 0.16 0.06 0.0e+00 0.22 0.22 0.2 0.22 3.7e-17 2.7e-17 2.3e-16 5.6e-18
6 Brain isoform ratio XM_006247570.4 0.04 0.02 2.5e-05 0.04 0.04 0.03 0.04 1.5e-04 5.1e-05 6.8e-04 7.0e-05
7 Brain alternative TSS NM_053314.3 0.25 0.08 0.0e+00 0.33 0.29 0.31 0.32 3.5e-31 2.6e-27 4.9e-29 5.8e-30
8 Brain alternative TSS XM_006247570.4 0.25 0.08 0.0e+00 0.32 0.29 0.31 0.31 4.8e-31 2.9e-27 5.3e-29 7.7e-30
9 PL gene expression Kcnj16 0.04 0.02 1.5e-05 0.03 0.02 0.03 0.03 3.1e-04 1.4e-03 6.2e-04 9.3e-04
10 Brain isoform ratio NM_053314.3 0.04 0.02 1.9e-05 0.04 0.05 0.05 0.04 1.2e-04 3.7e-05 2.0e-05 5.5e-05
11 LHb gene expression Kcnj16 0.48 0.13 4.7e-12 0.33 0.44 0.33 0.42 9.4e-09 7.3e-12 1.2e-08 3.9e-11
12 Brain gene expression Kcnj16 0.24 0.07 0.0e+00 0.4 0.4 0.41 0.41 3.2e-40 5.5e-40 2.4e-40 3.5e-41
13 Liver alternative polyA NM_053314.3 0.03 0.02 7.0e-03 0.02 0.01 0.01 0.02 2.5e-03 3.4e-02 3.0e-02 5.4e-03
14 Liver alternative polyA XM_006247570.4 0.03 0.02 8.7e-03 0.02 0.01 0.01 0.02 2.7e-03 4.9e-02 1.8e-02 6.3e-03
15 pVTA alternative TSS NM_053314.3 0.33 0.08 0.0e+00 0.39 0.37 0.38 0.38 2.2e-33 9.7e-31 9.2e-32 6.7e-32
16 pVTA alternative TSS XM_006247570.4 0.33 0.08 0.0e+00 0.4 0.37 0.38 0.38 5.3e-34 4.0e-31 2.3e-32 2.2e-32
17 IC gene expression Kcnj16 0.12 0.06 2.8e-05 0.11 0.12 0.1 0.12 1.8e-05 1.2e-05 3.6e-05 1.1e-05
18 BLA gene expression Kcnj16 0.11 0.06 1.6e-03 0.03 0.05 0.03 0.04 1.3e-02 1.1e-03 1.3e-02 4.2e-03
19 NAcc gene expression Kcnj16 0.04 0.02 9.9e-03 0 0.01 -0 0 2.4e-01 1.6e-02 4.2e-01 8.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
Bone: apparent density4.98.410.43.03.0-3.13.1-3.1-2.83.0-3.02.93.03.23.23.1-3.13.1-3.12.81.01.5
Area under the delay curve0.20.22.5-0.00.2-0.00.3-0.3-0.40.2-0.20.10.40.40.30.4-0.40.2-0.2-0.3-0.7-1.6
BMI with tail1.96.69.6-2.3-2.82.5-2.62.82.5-2.62.6-2.3-2.4-3.1-2.6-3.13.1-3.03.0-2.1-1.0-1.3
BMI without tail3.610.917.0-3.0-3.23.2-3.33.33.4-3.43.4-3.4-3.5-4.1-3.7-3.63.6-3.53.5-3.2-0.7-2.2
Body weight1.25.310.5-1.9-2.22.1-2.32.22.3-2.22.2-2.2-2.6-3.2-2.6-2.52.5-2.42.4-2.1-0.6-2.4
Weight adjusted by age1.92.94.1-1.6-1.91.7-1.71.91.7-1.91.9-1.8-1.4-2.0-1.5-2.02.0-2.02.0-1.1-0.20.3
Bone surface13.023.728.45.35.3-5.35.2-5.3-5.05.1-5.15.05.14.85.05.1-5.15.0-5.04.72.51.6
Bone volume9.617.220.64.54.5-4.54.5-4.5-4.44.5-4.54.34.34.44.54.2-4.24.2-4.24.01.50.9
Breakpoint value in progressive ratio session0.81.01.81.00.9-1.00.8-0.9-0.91.0-1.01.41.10.70.91.1-1.11.2-1.21.20.41.0
Number of licking bursts0.40.61.10.80.6-0.80.8-0.7-0.70.9-0.90.90.80.51.00.7-0.70.7-0.71.00.60.7
Context. condit. distance diff. score1.11.32.1-1.1-1.11.1-1.11.11.2-1.01.0-1.0-1.3-1.0-1.4-1.31.3-1.41.4-1.4-0.8-0.7
Locomotion velocity, session 10.10.10.50.40.2-0.40.7-0.2-0.30.2-0.20.40.40.20.30.2-0.20.3-0.30.70.10.5
Locomotion distance, session 10.91.14.5-1.2-1.21.1-0.91.20.8-1.01.0-0.9-0.7-0.7-0.6-1.01.0-0.90.9-1.1-2.1-1.0
Locomotion velocity, session 20.20.20.50.30.4-0.30.3-0.4-0.00.4-0.40.4-0.10.10.00.7-0.70.7-0.70.50.30.5
Locomotion distance, session 20.10.11.9-0.0-0.1-0.00.10.1-0.20.3-0.30.30.10.30.30.1-0.10.3-0.30.1-1.4-0.3
Locomotion velocity, session 31.11.21.7-1.2-1.31.2-1.31.30.9-1.21.2-1.0-1.0-1.0-1.0-1.11.1-1.21.2-0.8-1.0-0.6
Locomotion distance, session 30.00.00.20.10.0-0.10.3-0.0-0.3-0.00.00.30.40.40.3-0.00.00.0-0.00.3-0.30.0
Stereotopy head waving bouts, day 30.10.10.6-0.3-0.30.2-0.50.30.0-0.20.2-0.2-0.3-0.0-0.2-0.40.4-0.30.3-0.5-0.8-0.3
Stereotopy head waving duration, day 30.00.10.40.20.3-0.2-0.1-0.2-0.10.1-0.10.0-0.1-0.0-0.10.2-0.20.2-0.20.10.60.6
Locomotion velocity, session 71.01.11.71.11.3-1.21.1-1.2-1.10.9-0.90.91.01.11.01.3-1.31.2-1.20.90.4-0.0
Locomotion distance, session 70.70.81.50.90.9-1.00.7-0.9-1.10.9-0.91.20.80.90.90.9-0.90.8-0.8-0.1-1.1-1.2
Stereotopy head waving bouts, day 70.80.88.20.30.3-0.20.5-0.30.2-0.10.1-0.20.2-0.00.00.3-0.30.3-0.31.32.22.9
Stereotopy head waving duration, day 71.21.512.20.60.7-0.60.7-0.7-0.10.3-0.30.20.60.30.40.8-0.80.8-0.81.92.63.5
Locomotion velocity, session 80.10.20.60.60.4-0.50.5-0.4-0.50.4-0.40.60.20.30.10.3-0.30.3-0.30.1-0.4-0.8
Locomotion distance, session 80.60.82.5-0.9-0.80.9-0.80.90.8-0.50.5-0.5-1.1-0.7-1.0-0.80.8-0.90.9-1.2-1.6-1.0
Degree of sensitization distance0.50.52.30.60.7-0.60.3-0.7-0.60.6-0.60.60.20.40.40.7-0.70.6-0.6-0.6-1.0-1.5
Degree of sensitization stereotypy0.91.09.3-0.3-0.20.30.10.20.9-0.70.7-0.7-0.2-0.7-0.5-0.20.2-0.20.21.12.33.0
Conditioned locomotion0.30.40.9-0.4-0.70.4-0.40.70.1-0.50.5-0.30.1-0.00.1-1.01.0-0.90.9-0.5-0.8-0.4
Cocaine response after cond. corrected0.10.10.40.20.0-0.20.50.0-0.40.1-0.10.10.70.40.5-0.20.2-0.20.20.3-0.5-0.6
Cocaine response after cond. not corrected0.10.10.40.40.2-0.40.6-0.2-0.40.1-0.10.10.50.30.5-0.10.1-0.10.10.40.1-0.2
Cocaine response before conditioning0.10.10.9-0.00.00.1-0.20.00.4-0.40.4-0.4-0.5-0.5-0.1-0.10.1-0.10.1-0.30.90.6
Saline control response3.64.79.0-2.2-2.32.1-2.42.31.5-1.81.8-1.6-1.8-1.7-1.8-2.12.1-2.12.1-2.8-3.0-3.0
Bone: connectivity density5.99.311.73.13.0-3.23.1-3.1-3.13.2-3.23.23.43.23.43.2-3.23.2-3.23.11.11.9
Bone: cortical apparent density4.96.78.8-3.0-2.92.9-2.72.92.8-2.42.4-2.5-2.6-2.5-2.8-2.42.4-2.42.4-2.7-2.7-1.1
Bone: cortical area0.30.53.9-0.1-0.30.1-0.00.3-0.30.3-0.30.20.10.10.2-0.40.4-0.40.4-0.7-2.0-1.7
Bone: cortical porosity2.32.55.21.72.0-1.72.0-2.0-1.01.5-1.51.10.91.11.11.7-1.71.6-1.61.62.31.1
Bone: cortical porosity1.61.73.91.51.6-1.41.7-1.6-1.01.2-1.20.90.90.91.01.3-1.31.2-1.21.42.00.6
Bone: cortical thickness13.422.227.9-5.3-5.25.2-5.05.14.8-4.64.6-4.8-4.7-4.4-4.4-4.74.7-4.74.7-5.0-4.5-2.6
Bone: cortical thickness3.54.25.9-2.3-2.42.3-2.22.41.8-1.81.8-1.7-1.7-1.6-1.6-2.22.2-2.32.3-2.3-2.3-1.1
Bone: cortical tissue density4.66.38.4-2.9-2.82.8-2.62.82.7-2.42.4-2.4-2.5-2.4-2.7-2.42.4-2.32.3-2.6-2.6-1.0
Condit. Reinf. active minus inactive responses0.60.71.1-0.7-0.90.8-0.60.90.9-0.80.8-0.7-0.7-1.0-0.8-1.01.0-1.01.0-0.50.30.8
Condit. Reinf. active-inactive response ratio0.10.11.40.30.2-0.20.3-0.20.00.1-0.10.20.10.00.10.0-0.00.1-0.10.40.71.2
Condit. Reinf. active responses1.01.21.9-1.0-1.21.1-0.91.21.2-1.21.2-1.0-0.9-1.2-1.0-1.41.4-1.41.4-0.80.10.6
Condit. Reinf. inactive responses0.60.81.3-0.9-1.00.9-0.81.00.8-0.90.9-0.8-0.6-0.8-0.7-1.11.1-1.11.1-0.9-0.7-0.4
Incentive salience index mean0.30.41.7-0.5-0.70.5-0.40.70.7-0.60.6-0.5-0.3-0.6-0.4-0.70.7-0.70.7-0.00.41.3
Condit. Reinf. lever presses0.40.61.0-0.9-0.90.8-0.70.90.9-1.01.0-0.9-0.6-0.7-0.6-0.80.8-0.70.7-0.30.00.9
Condit. Reinf. active minus inactive responses0.10.21.50.40.4-0.40.5-0.40.10.2-0.20.10.1-0.10.10.0-0.00.0-0.00.41.21.0
Condit. Reinf. active-inactive response ratio0.30.31.5-0.1-0.10.2-0.10.10.6-0.50.5-0.6-0.5-0.6-0.5-0.40.4-0.50.5-0.11.21.1
Condit. Reinf. active responses0.20.30.50.70.7-0.70.7-0.7-0.50.6-0.60.60.60.50.50.4-0.40.4-0.40.20.10.0
Condit. Reinf. inactive responses0.30.41.10.60.6-0.60.5-0.6-0.70.7-0.70.70.80.70.70.5-0.50.6-0.60.0-1.0-0.7
Condit. Reinf. lever presses0.20.20.50.40.7-0.40.5-0.6-0.20.7-0.70.30.10.2-0.20.4-0.40.4-0.4-0.3-0.4-0.7
Condit. Reinf. lever reinforcers received0.20.20.50.60.7-0.60.6-0.6-0.40.7-0.70.60.40.40.30.3-0.30.3-0.3-0.0-0.2-0.4
Conditioned reinforcement - actives0.61.01.71.11.3-1.11.3-1.2-0.91.1-1.11.10.60.90.61.0-1.01.2-1.20.70.90.2
Conditioned reinforcement - inactives0.10.10.70.10.2-0.1-0.0-0.20.10.4-0.40.2-0.4-0.1-0.40.2-0.20.3-0.3-0.6-0.8-0.8
Conditioned locomotion0.10.10.5-0.1-0.10.1-0.10.10.2-0.10.1-0.2-0.4-0.4-0.4-0.20.2-0.10.1-0.5-0.2-0.7
Patch foraging indifference point 0 sec1.83.38.3-1.7-1.51.6-1.71.51.7-1.31.3-1.7-2.1-1.8-2.2-1.51.5-1.41.4-2.6-2.2-2.9
Patch foraging indifference point AUC0.71.11.6-1.2-1.11.1-1.31.21.0-1.01.0-1.0-1.2-1.0-1.0-1.11.1-1.01.0-0.9-0.5-0.6
Delay disc. indifference point, 0s delay0.20.30.4-0.6-0.50.6-0.40.50.5-0.60.6-0.6-0.3-0.4-0.3-0.40.4-0.50.5-0.6-0.5-0.3
Delay disc. indifference point, 16s delay0.70.71.20.81.0-0.81.1-1.0-0.80.6-0.60.61.00.91.11.0-1.00.8-0.80.90.80.1
Delay disc. indifference point, 2s delay0.50.55.0-0.00.2-0.10.1-0.2-0.40.4-0.40.30.30.50.20.5-0.50.3-0.3-0.5-1.7-2.2
Delay disc. indifference point, 24s delay1.31.42.71.21.3-1.21.5-1.3-1.11.1-1.10.91.31.21.21.1-1.10.9-0.91.51.60.7
Delay disc. indifference point, 4s delay0.50.63.3-0.8-0.60.7-0.60.60.3-0.60.6-0.5-0.4-0.4-0.4-0.30.3-0.60.6-1.0-1.4-1.8
Delay disc. indifference point, 8s delay0.30.42.0-0.8-0.60.7-0.50.60.4-0.50.5-0.4-0.4-0.3-0.4-0.40.4-0.40.4-0.8-0.7-1.4
Indifference point function ln k0.00.00.40.10.1-0.10.2-0.10.1-0.10.1-0.10.0-0.00.00.0-0.0-0.00.0-0.2-0.00.7
Indifference point function log k0.00.00.40.10.1-0.10.2-0.10.1-0.10.1-0.10.0-0.00.00.0-0.0-0.00.0-0.2-0.00.7
Patch foraging total patch changes 0 sec2.03.89.7-1.8-1.71.8-1.81.71.7-1.41.4-1.7-2.1-1.8-2.2-1.61.6-1.61.6-2.8-2.6-3.1
Patch foraging total patch changes 12 sec2.12.76.2-1.6-1.61.6-1.51.61.3-1.31.3-1.4-1.7-1.3-1.6-1.61.6-1.61.6-1.9-2.1-2.5
Patch foraging total patch changes 18 sec3.24.86.3-2.4-2.32.4-2.52.32.4-2.02.0-2.2-2.5-2.3-2.4-2.22.2-2.22.2-2.3-1.5-1.4
Patch foraging total patch changes 24 sec0.61.03.2-0.8-0.80.8-0.80.90.7-0.60.6-0.7-1.1-0.8-1.0-1.01.0-0.90.9-1.3-1.5-1.8
Patch foraging total patch changes 6 sec3.85.88.8-2.6-2.42.6-2.72.42.8-2.22.2-2.5-3.0-2.9-2.9-2.22.2-2.22.2-2.6-1.0-1.6
Patch foraging time to switch 0 sec1.02.12.81.61.6-1.61.5-1.6-1.51.3-1.31.41.71.41.51.5-1.51.4-1.41.61.30.9
Patch foraging water rate 0 sec2.85.97.1-2.6-2.72.6-2.42.72.6-2.32.3-2.4-2.4-2.6-2.4-2.62.6-2.62.6-2.4-1.8-0.9
Patch foraging water rate 12 sec1.32.75.3-1.7-1.81.7-1.71.81.6-1.31.3-1.4-1.7-1.8-1.6-1.51.5-1.41.4-2.0-2.3-1.3
Patch foraging water rate 18 sec1.21.92.3-1.4-1.51.4-1.41.51.5-1.51.5-1.3-1.5-1.3-1.3-1.51.5-1.41.4-1.4-1.00.3
Patch foraging water rate 24 sec0.30.41.0-0.8-0.50.8-0.60.50.7-0.30.3-0.5-0.8-0.4-0.7-0.50.5-0.60.6-0.9-1.0-0.5
Patch foraging water rate 6 sec1.62.33.2-1.6-1.71.5-1.31.71.5-1.61.6-1.6-1.1-1.3-1.1-1.71.7-1.71.7-1.4-1.8-0.1
Seeking ratio, delayed vs. immediate footshock1.92.44.1-1.4-1.61.5-1.51.61.6-1.71.7-2.0-1.6-1.9-1.6-1.71.7-1.61.6-1.10.8-0.3
Distance traveled before self-admin1.41.82.6-1.3-1.31.3-1.21.31.5-1.61.6-1.6-1.3-1.3-1.3-1.51.5-1.51.5-1.20.00.3
Distance traveled after self-admin1.31.62.8-1.1-1.21.1-1.21.31.2-1.71.7-1.6-1.1-1.2-0.9-1.61.6-1.61.6-0.80.10.7
Extensor digitorum longus weight0.00.10.70.1-0.00.0-0.30.00.0-0.30.3-0.10.0-0.5-0.20.1-0.10.1-0.10.10.8-0.2
Bone: elastic displacement4.24.97.0-2.6-2.52.6-2.42.52.6-2.42.4-2.3-2.3-2.1-2.1-2.22.2-2.22.2-1.9-0.70.6
Bone: elastic work0.81.11.9-1.4-1.31.3-1.21.21.3-0.80.8-0.8-1.0-1.0-0.9-1.01.0-0.90.9-1.1-1.20.1
Bone: endosteal estimation17.538.452.97.36.9-7.16.9-6.8-6.96.7-6.76.86.55.96.25.9-5.95.9-5.95.73.60.7
Bone: endosteal perimeter16.334.647.46.96.5-6.76.6-6.4-6.66.4-6.46.46.35.66.15.6-5.65.7-5.75.42.90.5
Epididymis fat weight2.17.38.8-2.8-2.92.8-2.62.82.7-2.72.7-2.7-2.8-3.0-2.5-2.82.8-2.82.8-2.8-1.9-2.3
Delta time in closed arm before/after self-admin0.10.10.20.20.3-0.20.4-0.3-0.10.1-0.10.10.20.30.20.1-0.10.1-0.10.30.40.4
Delta time in open arm before/after self-admin0.70.71.30.90.9-0.90.9-0.8-1.10.8-0.80.80.91.20.80.7-0.70.8-0.80.4-0.5-0.5
Diff in mean of infusions in LGA sessions1.21.52.4-1.4-1.31.4-1.51.21.4-1.11.1-0.9-1.4-1.5-1.4-0.80.8-1.01.0-1.5-1.2-0.8
Delay discount exponential model param0.20.32.9-0.0-0.30.1-0.40.30.4-0.20.2-0.1-0.4-0.4-0.3-0.40.4-0.20.20.30.81.7
Extinction: sum of active levers before priming2.73.06.01.91.9-1.92.0-1.9-1.41.4-1.41.41.61.21.71.5-1.51.4-1.42.02.42.2
Active lever presses in extinction session 63.93.95.32.02.1-2.01.8-2.1-2.22.1-2.12.22.02.22.02.3-2.32.1-2.10.9-0.9-1.0
Bone: final force1.11.82.71.51.4-1.51.6-1.3-1.61.6-1.61.61.41.51.41.1-1.11.1-1.10.9-0.5-0.8
Bone: final moment0.81.21.91.31.3-1.31.4-1.2-1.31.3-1.31.31.11.21.10.9-0.90.9-0.90.6-0.3-0.8
Food consumed during 24 hour testing period0.20.30.90.30.4-0.40.2-0.4-0.50.7-0.70.40.40.40.40.6-0.60.6-0.60.2-0.9-0.6
Glucose0.20.32.5-0.2-0.50.2-0.20.4-0.20.3-0.30.4-0.10.10.0-0.40.4-0.40.4-0.4-1.6-1.4
Heart weight1.82.73.6-1.7-1.71.8-1.61.71.9-1.61.6-1.9-1.6-1.9-1.8-1.81.8-1.81.8-1.5-0.7-0.9
Delay discount hyperbolic model param0.30.33.3-0.0-0.30.1-0.30.30.4-0.30.3-0.2-0.4-0.4-0.3-0.40.4-0.20.20.30.91.8
Intermittent access intake day 1-15 change0.30.61.6-0.9-0.70.9-0.80.70.9-0.40.4-0.7-1.3-0.8-1.2-0.50.5-0.50.5-0.9-0.7-1.0
Intermittent access intake escalation0.61.22.4-1.3-1.11.3-1.11.11.2-0.80.8-1.1-1.5-1.1-1.6-0.90.9-0.90.9-1.2-0.8-1.1
Intermittent access intake escalation 20.91.02.0-1.2-0.91.1-0.90.91.1-0.70.7-1.2-1.4-0.9-1.4-0.90.9-0.80.8-1.1-0.6-1.1
Intermitt. access day 1 inactive lever presses0.20.81.7-0.9-1.00.9-1.11.01.1-0.80.8-0.8-0.8-1.3-0.9-0.80.8-0.80.8-0.5-0.40.5
Intermitt. access day 15 inactive lever presses0.20.41.3-0.8-0.90.8-1.00.80.7-0.40.4-0.4-0.6-0.8-0.6-0.40.4-0.40.4-0.5-1.1-0.1
Intermitt. access escalation Index0.40.61.1-0.7-0.60.7-0.70.60.9-0.80.8-0.9-0.8-0.7-0.8-0.90.9-0.90.9-0.41.10.8
Intermittent access day 1 total infusions0.20.30.80.70.6-0.70.4-0.5-0.60.6-0.60.90.50.20.40.5-0.50.6-0.60.1-0.1-0.2
Intermittent access day 15 total infusions0.30.41.0-0.6-0.60.6-0.70.60.7-0.50.5-0.3-1.0-0.9-1.0-0.50.5-0.50.5-0.9-0.3-0.4
Intermittent access terminal intake (last 3 days)0.00.10.20.10.1-0.10.0-0.1-0.00.2-0.20.3-0.3-0.2-0.40.2-0.20.3-0.3-0.3-0.3-0.5
Intermittent access total infusions0.00.00.20.0-0.10.0-0.10.2-0.0-0.00.00.3-0.2-0.4-0.3-0.10.10.0-0.0-0.4-0.4-0.5
Intermittent access day 1 locomotion0.10.10.3-0.2-0.20.2-0.40.20.2-0.30.3-0.2-0.2-0.5-0.1-0.00.0-0.10.1-0.5-0.5-0.4
Intermittent access day 15 total locomotion2.03.74.7-2.1-1.92.1-2.11.92.0-1.91.9-1.8-2.1-2.1-2.1-1.71.7-1.91.9-2.2-1.6-1.4
Intermittent access total locomotion1.61.92.8-1.4-1.41.4-1.61.41.4-1.51.5-1.3-1.5-1.7-1.5-1.31.3-1.31.3-1.6-1.1-1.1
Intermittent access standard deviation0.40.91.9-0.8-0.90.8-0.80.90.9-0.80.8-0.5-1.4-1.0-1.4-0.90.9-0.80.8-1.1-0.6-1.1
Left kidney weight0.00.11.90.00.0-0.0-0.0-0.0-0.10.3-0.30.2-0.3-0.2-0.30.1-0.10.1-0.1-0.1-0.4-1.4
Right kidney weight0.10.54.80.20.0-0.20.2-0.0-0.50.5-0.50.5-0.10.10.00.1-0.10.2-0.2-0.2-1.8-2.2
Cocaine induced anxiety0.10.21.70.20.1-0.10.2-0.10.10.0-0.00.10.2-0.10.1-0.00.00.1-0.10.61.21.3
Post-drug Anxiety0.10.10.50.20.2-0.20.3-0.2-0.20.2-0.20.20.50.30.40.2-0.20.2-0.20.60.60.7
Baseline Anxiety0.20.21.50.20.2-0.30.1-0.2-0.50.3-0.30.10.30.50.30.3-0.30.2-0.2-0.2-1.2-1.0
Tail length0.51.94.5-1.2-1.01.3-1.41.01.7-1.21.2-1.5-2.0-2.1-1.9-1.01.0-1.01.0-1.60.5-1.4
Length with tail0.20.86.4-0.6-0.40.6-0.80.40.7-0.30.3-0.6-1.2-1.1-1.0-0.30.3-0.30.3-1.1-0.6-2.5
Length without tail0.10.44.1-0.1-0.20.1-0.20.2-0.30.3-0.30.4-0.10.10.2-0.10.10.1-0.1-0.5-1.8-2.0
Times rat made contact with spout0.70.81.3-1.0-1.01.0-1.11.00.9-1.11.1-1.1-0.8-1.0-0.8-0.70.7-0.60.6-0.7-0.9-0.6
Lifetime Intake0.10.10.60.20.1-0.20.0-0.0-0.20.2-0.20.5-0.2-0.2-0.20.1-0.10.2-0.2-0.4-0.6-0.8
Liver weight, left0.40.71.61.11.0-1.11.2-1.0-1.00.7-0.70.70.70.70.60.7-0.70.7-0.70.5-0.4-1.3
Liver weight, right0.20.40.5-0.6-0.60.6-0.40.60.4-0.60.6-0.4-0.6-0.6-0.6-0.60.6-0.70.7-0.4-0.7-0.7
Locomotor activity0.40.61.0-0.7-0.80.7-0.50.80.9-0.60.6-0.5-0.9-0.9-0.8-0.90.9-1.01.0-0.9-0.7-0.2
Locomotor testing distance1.93.55.2-1.8-1.91.9-1.62.02.0-1.81.8-1.8-1.8-2.0-1.8-2.12.1-2.32.3-1.8-1.5-0.4
Locomotor testing rearing5.711.413.8-3.5-3.53.5-3.43.53.6-3.23.2-3.4-3.6-3.7-3.4-3.53.5-3.73.7-3.5-2.4-1.5
Locomotion in novel chamber0.70.91.51.11.1-1.11.2-1.1-0.80.9-0.90.80.90.91.00.9-0.90.9-0.90.80.70.8
Locomotion in novel chamber post-restriction0.20.31.50.20.3-0.30.1-0.3-0.30.7-0.70.2-0.10.70.20.4-0.40.6-0.6-0.6-1.0-1.2
Fecal boli incidents, locomotor time 11.11.62.81.21.4-1.31.2-1.4-1.61.1-1.10.81.51.71.41.3-1.31.3-1.30.90.4-1.0
Change in fecal boli incidents, locomotor task0.20.20.9-0.5-0.30.5-0.20.20.9-0.00.0-0.2-0.7-0.4-0.5-0.00.0-0.10.1-0.4-0.10.9
Time >=10cm from walls, locomotor time 11.31.42.31.41.3-1.51.4-1.2-1.51.2-1.21.31.21.31.11.0-1.01.3-1.30.9-0.1-0.5
Bouts of movement, locomotor time 11.51.73.2-1.2-1.11.3-1.51.21.3-1.01.0-1.4-1.6-1.4-1.8-1.21.2-1.21.2-1.6-0.5-1.6
Total resting periods, locomotor time 10.70.72.1-0.8-0.70.8-0.90.70.7-0.60.6-1.0-1.0-0.8-1.3-0.80.8-0.70.7-1.0-0.2-1.4
Rest time, locomotor task time 10.20.20.60.30.5-0.30.2-0.6-0.30.6-0.60.10.30.40.20.8-0.80.6-0.60.30.5-0.4
Distance moved, locomotor task time 10.91.31.9-1.1-1.31.1-1.01.41.0-1.41.4-0.7-1.0-1.1-1.0-1.41.4-1.41.4-0.9-0.90.1
Vertical activity count, locomotor time 10.30.61.6-0.6-1.00.7-0.91.00.7-0.70.7-0.1-0.7-1.0-0.6-0.90.9-0.60.6-0.8-1.3-0.3
Time >=10cm from walls, locomotor time 20.60.81.4-0.8-0.90.8-0.90.91.2-0.90.9-1.1-1.0-1.1-0.8-1.01.0-1.01.0-0.8-0.10.9
Bouts of movement, locomotor time 20.50.85.3-0.6-0.60.6-0.90.60.3-0.30.3-0.7-0.6-0.5-0.7-0.50.5-0.70.7-1.4-1.8-2.3
Total resting periods, locomotor time 20.50.96.7-0.7-0.60.6-0.80.60.3-0.30.3-0.7-0.6-0.4-0.7-0.40.4-0.50.5-1.4-1.9-2.6
Rest time, locomotor task time 22.02.53.61.41.7-1.51.6-1.7-1.61.7-1.71.51.51.81.51.9-1.91.9-1.91.50.80.1
Distance moved, locomotor task time 22.63.04.8-1.6-1.91.7-1.71.91.6-2.12.1-1.7-1.5-1.8-1.5-2.02.0-2.22.2-1.5-1.10.2
Vertical activity count, locomotor time 21.52.02.6-1.2-1.41.3-1.51.41.3-1.61.6-1.3-1.4-1.6-1.3-1.51.5-1.61.6-1.6-1.2-0.8
Light reinforcement 10.20.41.3-0.7-0.70.7-0.80.70.2-0.50.5-0.60.0-0.3-0.2-0.60.6-0.70.7-0.5-1.1-0.6
Light reinforcement 20.60.91.81.00.9-1.01.2-0.9-1.20.8-0.81.01.31.01.10.7-0.70.6-0.61.20.60.4
Bone: marrow area16.936.850.77.16.8-7.06.8-6.6-6.76.6-6.66.66.35.86.15.7-5.75.8-5.85.63.50.6
Bone: maximum diameter8.616.020.84.64.3-4.54.4-4.2-4.54.6-4.64.54.44.04.33.8-3.83.8-3.83.41.10.1
Bone: maximum force2.44.36.32.32.2-2.32.4-2.2-2.42.5-2.52.32.22.22.11.9-1.91.9-1.91.3-0.7-1.3
Bone: maximum moment1.83.14.52.02.0-2.02.0-1.9-2.02.1-2.11.91.81.81.71.6-1.61.6-1.60.9-0.6-1.3
Mean time between licks in bursts0.20.50.90.90.9-0.80.5-0.9-0.40.8-0.80.60.50.20.50.9-0.91.0-1.00.60.90.5
Mean num. licks in bursts0.81.22.2-1.1-1.01.1-1.21.00.8-1.21.2-1.2-0.9-0.7-1.0-0.90.9-0.90.9-1.3-1.5-1.4
Cd content in liver0.91.01.7-0.9-0.90.9-0.71.01.0-1.21.2-1.1-1.1-0.7-1.0-1.31.3-1.31.3-0.9-0.3-0.0
Co content in liver0.80.92.1-0.9-0.60.9-1.00.61.4-1.11.1-1.3-1.0-1.2-0.9-0.50.5-0.40.4-0.51.11.4
Cu content in liver0.20.20.40.40.4-0.40.4-0.4-0.50.5-0.50.50.60.50.50.4-0.40.3-0.30.60.30.3
Fe content in liver0.50.73.8-0.3-0.20.4-0.20.20.8-1.01.0-0.8-0.7-0.7-0.9-0.40.4-0.40.40.12.01.6
K content in liver2.22.13.21.21.2-1.31.3-1.2-1.61.8-1.81.71.81.61.61.6-1.61.5-1.51.2-0.7-0.1
Mg content in liver1.41.42.40.91.0-1.00.9-1.0-1.11.6-1.61.31.41.41.41.3-1.31.3-1.30.9-0.40.6
Mn content in liver1.71.83.31.21.2-1.31.2-1.3-1.61.5-1.51.41.81.81.61.4-1.41.4-1.41.1-0.30.4
Na content in liver1.21.21.71.01.1-1.11.2-1.1-1.31.3-1.31.01.21.31.01.2-1.21.3-1.31.0-0.5-0.3
Rb content in liver0.50.51.2-0.7-1.10.7-0.81.10.3-0.70.7-0.3-0.1-0.1-0.1-1.11.1-1.11.10.1-0.30.3
Se content in liver0.20.20.60.0-0.1-0.10.30.0-0.40.8-0.80.70.60.60.60.1-0.10.1-0.10.5-0.60.1
Sr content in liver0.20.20.40.30.5-0.2-0.0-0.50.2-0.20.2-0.3-0.1-0.2-0.10.6-0.60.6-0.6-0.10.50.6
Zn content in liver1.01.11.91.11.0-1.11.2-1.0-1.11.1-1.11.11.41.21.40.9-0.90.9-0.91.20.40.9
Bone: minimum diameter8.816.021.84.64.3-4.54.5-4.3-4.64.7-4.74.44.33.94.33.7-3.73.8-3.83.40.9-0.6
Time in familiar zone, hab. session 10.10.10.30.30.5-0.30.5-0.5-0.20.0-0.0-0.3-0.20.40.10.2-0.20.0-0.00.00.2-0.6
Time in novel zone, hab. session 10.20.20.7-0.5-0.80.5-0.70.70.3-0.10.10.10.0-0.5-0.3-0.50.5-0.40.4-0.2-0.90.3
Total zone transitions, hab. session 10.40.50.8-0.8-0.80.8-0.80.80.8-0.60.6-0.7-0.8-0.9-0.7-0.70.7-0.70.7-0.7-0.7-0.0
Total locomotion distance, hab. session 11.11.52.1-1.4-1.51.4-1.21.51.2-1.11.1-1.2-1.0-1.2-1.1-1.31.3-1.41.4-1.2-1.4-0.4
Locomotion velocity, hab. session 10.81.11.7-1.2-1.31.2-1.01.31.0-1.01.0-1.0-0.9-1.2-0.9-1.21.2-1.21.2-0.8-0.70.1
Time in familiar zone, hab. session 20.30.30.6-0.2-0.30.30.10.30.6-0.70.7-0.8-0.6-0.5-0.3-0.70.7-0.80.8-0.00.70.6
Time in novel zone, hab. session 21.71.83.41.11.1-1.10.8-1.1-1.51.7-1.71.91.51.41.31.5-1.51.6-1.60.8-0.8-0.0
Total zone transitions, hab. session 20.10.11.1-0.3-0.20.3-0.20.20.4-0.30.3-0.3-0.1-0.3-0.1-0.10.1-0.10.10.20.41.0
Total locomotion distance, hab. session 20.70.91.3-1.1-1.11.1-1.01.11.0-1.01.0-1.1-0.8-0.9-0.9-1.01.0-1.01.0-0.6-0.60.1
Locomotion velocity, hab. session 20.70.91.3-1.1-1.11.1-0.91.10.9-1.01.0-1.0-0.7-0.9-0.8-1.11.1-1.01.0-0.6-0.60.1
Novel to familiar place preference ratio0.20.20.6-0.3-0.20.3-0.30.20.5-0.30.3-0.4-0.5-0.6-0.7-0.20.2-0.30.3-0.8-0.2-0.7
Novelty place preference0.10.10.4-0.1-0.00.2-0.10.00.4-0.20.2-0.2-0.4-0.5-0.5-0.00.0-0.20.2-0.60.0-0.4
Time in novel zone, NPP test0.10.10.4-0.2-0.10.2-0.20.10.5-0.20.2-0.3-0.4-0.6-0.6-0.10.1-0.20.2-0.60.0-0.2
Total zone transitions, NPP test0.40.60.9-0.9-0.90.9-0.80.90.7-0.80.8-0.8-0.6-0.5-0.6-0.70.7-0.70.7-0.6-1.0-0.0
Total locomotion distance, NPP test2.63.55.3-2.2-2.32.1-1.82.31.7-1.71.7-1.8-1.5-1.5-1.4-2.22.2-2.12.1-1.5-2.0-0.3
Locomotion velocity, NPP test3.14.36.2-2.4-2.52.3-2.02.51.8-1.91.9-2.0-1.7-1.6-1.7-2.42.4-2.32.3-1.8-2.3-1.0
Intraocular pressure0.10.10.70.1-0.1-0.0-0.10.10.2-0.30.3-0.2-0.1-0.6-0.1-0.40.4-0.50.50.30.80.5
Delta distance traveled before/after self-admin0.20.21.1-0.2-0.40.2-0.30.40.3-0.60.6-0.6-0.2-0.4-0.1-0.60.6-0.60.60.20.41.0
Delta ambulatory time before/after self-admin0.00.00.20.20.2-0.20.1-0.1-0.2-0.10.1-0.10.10.20.3-0.10.1-0.10.10.30.40.4
Parametrial fat weight1.63.96.32.22.1-2.22.2-2.0-2.52.1-2.11.92.32.52.21.6-1.61.6-1.61.90.6-0.0
Pavlov. Cond. lever latency2.32.94.41.71.9-1.81.8-1.9-1.92.1-2.12.01.52.01.51.7-1.71.7-1.71.20.3-0.5
Pavlov. Cond. magazine entry latency0.70.91.4-1.1-1.21.1-0.81.11.2-0.90.9-1.0-0.7-1.0-0.8-1.11.1-1.11.1-0.6-0.40.6
Pavlov. Cond. change in total contacts2.02.13.7-1.5-1.61.6-1.51.51.9-1.41.4-1.5-1.5-1.8-1.5-1.41.4-1.41.4-1.1-0.21.0
Pavlov. Cond. index score1.41.72.6-1.4-1.61.4-1.31.61.4-1.51.5-1.4-0.9-1.4-1.0-1.51.5-1.51.5-0.9-0.60.5
Pavlov. Cond. latency score1.41.72.6-1.4-1.61.4-1.31.61.5-1.51.5-1.4-1.0-1.4-1.0-1.41.4-1.41.4-0.9-0.60.5
Pavlov. Cond. lever contacts1.62.02.9-1.5-1.61.5-1.51.51.6-1.71.7-1.6-1.3-1.6-1.3-1.41.4-1.41.4-1.2-0.40.1
Pavlov. Cond. magazine entry number1.01.21.81.21.4-1.21.0-1.3-1.31.0-1.01.00.81.10.91.3-1.31.3-1.30.90.7-0.6
Pavlov. Cond. intertrial magazine entries0.10.20.5-0.1-0.10.1-0.10.10.4-0.60.6-0.5-0.6-0.6-0.5-0.30.3-0.40.4-0.20.7-0.3
Pavlov. Cond. lever-magazine prob. diff.1.01.22.0-1.2-1.41.2-1.11.41.2-1.21.2-1.1-0.7-1.1-0.8-1.31.3-1.31.3-0.7-0.60.6
Pavlov. Cond. response bias0.91.21.7-1.2-1.31.2-1.01.21.3-1.11.1-1.1-0.8-1.1-0.8-1.21.2-1.21.2-0.7-0.40.7
Pavlov. Cond. lever latency0.81.02.2-1.1-1.31.1-1.01.20.9-1.51.5-1.1-0.9-0.9-0.5-1.21.2-1.01.0-0.30.30.3
Pavlov. Cond. magazine entry latency0.70.82.00.81.1-0.70.8-1.1-0.41.2-1.20.90.30.40.11.1-1.11.1-1.10.81.40.5
Pavlov. Cond. change in total contacts1.21.93.21.41.7-1.41.4-1.7-1.01.8-1.81.61.11.00.71.6-1.61.6-1.61.10.90.7
Pavlov. Cond. index score1.31.83.11.31.6-1.31.4-1.6-0.91.8-1.81.40.90.90.61.5-1.51.5-1.51.01.10.6
Pavlov. Cond. latency score1.21.62.91.21.5-1.21.3-1.5-0.81.7-1.71.40.90.80.61.4-1.41.4-1.41.01.10.6
Pavlov. Cond. lever contacts0.70.91.81.01.2-1.00.9-1.2-0.81.3-1.31.00.80.80.51.1-1.11.1-1.10.3-0.2-0.1
Pavlov. Cond. magazine entry number0.40.51.4-0.4-0.80.4-0.60.80.0-1.01.0-0.80.1-0.10.2-0.80.8-0.80.8-0.5-1.2-0.5
Pavlov. Cond. intertrial magazine entries1.62.34.61.61.3-1.61.5-1.3-2.11.5-1.51.62.02.02.01.2-1.21.3-1.31.1-1.1-1.0
Pavlov. Cond. lever-magazine prob. diff.1.31.83.11.31.6-1.31.4-1.6-0.91.8-1.81.40.90.90.61.5-1.51.5-1.51.11.10.6
Pavlov. Cond. response bias1.01.42.71.11.4-1.11.2-1.4-0.91.7-1.71.40.91.00.61.4-1.41.4-1.40.60.10.1
Time in closed arm before self-admin0.20.21.4-0.2-0.50.3-0.40.40.5-0.20.2-0.0-0.4-0.6-0.3-0.30.3-0.10.10.30.91.2
Time in closed arm after self-admin1.01.11.9-1.0-1.21.1-1.21.11.3-1.01.0-0.9-1.1-1.4-0.8-1.01.0-1.01.0-0.30.51.2
Time in open arm before self-admin0.20.30.5-0.6-0.50.6-0.60.40.6-0.30.3-0.5-0.6-0.6-0.5-0.20.2-0.30.3-0.7-0.6-0.6
Time in open arm after self-admin0.60.71.00.90.9-0.91.0-0.9-1.00.9-0.90.90.70.90.70.8-0.80.9-0.90.4-0.3-0.7
Bone: periosteal estimation8.317.524.34.94.6-4.84.8-4.5-4.84.7-4.74.74.54.14.43.8-3.83.8-3.83.61.5-0.4
Bone: periosteal perimeter6.110.414.53.83.6-3.73.5-3.5-3.63.6-3.63.53.43.03.43.2-3.23.1-3.12.71.2-0.3
Bone: post-yield work3.24.77.52.42.2-2.42.3-2.1-2.72.6-2.62.42.52.42.51.9-1.91.9-1.91.5-0.7-1.3
Progressive ratio test 1 active lever presses1.82.23.8-1.4-1.51.5-1.71.51.4-1.41.4-1.1-1.6-1.9-1.6-1.21.2-1.31.3-1.9-1.4-1.4
Progressive ratio test 1 breakpoint1.41.73.1-1.3-1.41.3-1.51.41.2-1.21.2-0.9-1.5-1.7-1.4-1.11.1-1.11.1-1.8-1.3-1.4
Progressive ratio test 1 inactive lever presses0.71.03.7-1.0-1.11.0-1.41.11.0-0.70.7-0.6-1.0-1.1-1.0-0.60.6-0.60.6-1.3-1.9-0.9
Progressive ratio test 2 active lever presses0.70.91.7-0.8-0.90.9-0.90.91.0-0.80.8-0.6-1.3-1.3-1.2-0.80.8-0.80.8-1.2-0.5-0.7
Progressive ratio test 2 breakpoint0.91.01.9-0.9-1.01.0-1.01.01.1-1.01.0-0.7-1.4-1.3-1.3-0.90.9-0.90.9-1.3-0.4-0.7
Progressive ratio test 2 inactive lever presses0.30.62.0-0.7-0.60.7-0.80.60.6-0.50.5-0.5-0.9-0.8-0.7-0.50.5-0.50.5-1.1-1.1-1.4
Incentive Sensitization - Responses0.10.10.4-0.2-0.20.2-0.30.20.4-0.30.3-0.2-0.6-0.5-0.5-0.30.3-0.20.2-0.5-0.3-0.6
Incentive Sensitization - Breakpoint0.10.20.4-0.3-0.30.3-0.30.30.4-0.40.4-0.2-0.6-0.5-0.6-0.40.4-0.30.3-0.5-0.3-0.5
Sum of active levers in priming session hrs 5-60.40.30.7-0.7-0.60.7-0.70.60.8-0.60.6-0.5-0.6-0.7-0.5-0.50.5-0.50.5-0.40.20.5
Progressive ratio2.23.55.22.12.1-2.12.3-2.1-1.91.9-1.91.91.92.01.81.8-1.81.8-1.81.81.30.6
Food seeking constrained by brief footshock0.10.11.00.10.3-0.10.2-0.20.10.0-0.00.1-0.40.0-0.30.1-0.1-0.00.0-0.01.00.3
Seeking ratio, punishment vs. effort1.82.73.9-1.7-1.61.7-1.91.61.8-1.71.7-1.7-2.0-1.7-1.8-1.61.6-1.61.6-1.7-0.6-0.6
Retroperitoneal fat weight1.66.98.1-2.7-2.72.7-2.82.72.7-2.72.7-2.7-2.8-2.9-2.8-2.72.7-2.72.7-2.7-1.4-1.7
Reaction time number correct1.22.33.01.71.7-1.71.7-1.7-1.71.6-1.61.51.51.71.61.5-1.51.6-1.61.10.0-0.3
Reaction time mean minus median0.61.52.21.31.4-1.31.3-1.4-1.21.2-1.21.11.21.21.11.5-1.51.5-1.51.20.80.2
Reaction time mean minus median AUC1.84.66.12.32.2-2.32.4-2.2-2.52.3-2.32.22.52.52.22.1-2.12.2-2.22.00.50.2
Reaction time num false alarms0.40.61.10.80.9-0.80.8-0.9-0.81.0-1.01.10.70.80.80.7-0.70.7-0.70.20.3-0.5
Reaction time num false alarms AUC1.62.53.71.71.8-1.71.7-1.8-1.71.9-1.91.91.61.71.61.6-1.61.6-1.61.00.6-0.3
Reaction time trials correct on left1.22.33.01.71.7-1.71.7-1.7-1.71.6-1.61.51.51.71.61.5-1.51.6-1.61.10.0-0.3
Reaction time trials on left1.42.63.41.81.8-1.81.9-1.8-1.81.7-1.71.61.61.91.81.6-1.61.7-1.71.20.0-0.3
Reaction time mean0.20.30.70.50.7-0.50.4-0.7-0.10.4-0.40.40.00.10.10.9-0.90.8-0.80.40.80.8
Reaction time mean AUC0.30.51.00.70.8-0.60.4-0.8-0.20.5-0.50.60.10.10.11.0-1.01.0-1.00.50.90.8
Median of all reaction times0.20.21.40.30.4-0.20.1-0.40.20.1-0.10.3-0.3-0.2-0.20.6-0.60.6-0.60.30.91.2
Reaction time omissions3.04.46.22.22.3-2.32.2-2.3-2.42.3-2.32.02.52.42.22.2-2.22.2-2.21.70.20.2
Reaction time false alarm rate0.10.10.40.30.4-0.30.3-0.4-0.30.7-0.70.60.20.30.20.3-0.30.3-0.3-0.10.4-0.2
Reaction time premature initiation rate4.96.89.3-2.9-3.12.8-2.73.02.4-2.92.9-2.7-2.1-2.3-2.0-2.92.9-2.82.8-2.4-2.0-1.3
Reaction time premature initiations0.81.52.8-1.3-1.51.2-1.11.40.8-1.31.3-1.2-0.6-0.6-0.5-1.41.4-1.31.3-1.2-1.7-1.2
Std. dev. reaction times0.81.52.01.31.3-1.31.2-1.3-1.21.3-1.31.21.21.31.11.4-1.41.4-1.41.00.40.3
Reaction time trials completed1.42.63.41.81.8-1.81.9-1.8-1.81.7-1.71.61.61.91.81.6-1.61.7-1.71.20.0-0.3
Reaction time trials AUC1.22.33.11.71.7-1.71.7-1.7-1.71.6-1.61.51.61.71.71.5-1.51.6-1.61.1-0.1-0.3
Run reversals in cocaine runway, females4.24.25.5-2.3-2.32.3-2.12.32.2-2.32.3-2.1-1.9-2.0-2.0-2.22.2-2.22.2-1.4-0.1-0.1
Run reversals in cocaine runway, males0.20.20.3-0.1-0.20.1-0.10.30.1-0.60.6-0.3-0.3-0.4-0.1-0.60.6-0.60.6-0.20.6-0.1
Latency to leave start box in cocaine runway0.50.61.0-0.7-1.00.8-1.01.00.5-0.80.8-0.4-0.4-0.9-0.8-0.80.8-0.70.7-0.5-0.9-0.5
Latency to leave start box in cocaine runway, F3.13.54.8-1.7-2.11.8-2.12.11.4-1.91.9-1.3-1.6-1.9-1.9-1.91.9-1.71.7-2.0-2.2-2.0
Latency to leave start box in cocaine runway, M1.11.05.40.70.6-0.70.8-0.6-0.50.7-0.70.71.00.70.80.7-0.70.7-0.71.71.62.3
Std. dev. time between licks in bursts0.20.30.9-0.6-0.50.6-1.00.50.7-0.50.5-0.7-0.6-0.6-0.8-0.40.4-0.40.4-0.8-0.3-0.2
Total sessions with >9 infusions0.60.82.6-0.7-0.70.7-0.90.70.6-0.70.7-0.4-1.0-0.8-1.0-0.50.5-0.50.5-1.3-1.5-1.6
Short access day 1 total inactive lever presses0.50.73.1-0.5-0.70.5-1.00.70.4-0.70.7-0.4-0.8-0.7-0.7-0.60.6-0.50.5-1.2-1.7-1.5
Short access day 10 total inactive lever presses0.10.31.00.50.5-0.50.3-0.5-0.20.6-0.60.50.50.20.60.6-0.60.6-0.60.3-0.11.0
Short access day 1 total infusions0.50.62.9-0.5-0.50.5-0.70.60.5-0.50.5-0.3-0.9-0.7-1.0-0.50.5-0.50.5-1.3-1.4-1.7
Short access day 10 total infusions0.70.96.7-0.3-0.40.3-0.60.40.0-0.30.3-0.0-0.7-0.3-0.7-0.30.3-0.20.2-1.6-2.3-2.6
Short access total infusions0.10.21.40.10.0-0.1-0.1-0.0-0.10.1-0.10.3-0.4-0.2-0.30.1-0.10.2-0.2-0.7-1.0-1.2
Short access day 1 locomotion5.36.69.4-2.5-2.62.5-2.82.62.3-2.62.6-2.3-2.6-2.6-2.6-2.52.5-2.52.5-3.1-2.6-2.4
Short access day 10 total locomotion0.20.40.8-0.4-0.30.5-0.60.40.6-0.90.9-0.6-0.7-0.9-0.7-0.60.6-0.60.6-0.90.1-0.6
Short access total locomotion1.82.24.0-1.4-1.31.4-1.61.31.2-1.51.5-1.2-1.5-1.4-1.4-1.31.3-1.31.3-2.0-1.8-2.0
One hour access (0.3 mA shock)0.20.20.30.60.5-0.60.6-0.4-0.50.5-0.50.50.10.40.30.4-0.40.5-0.50.2-0.3-0.4
Compulsive drug intake0.40.51.00.80.6-0.80.6-0.6-1.00.6-0.60.60.90.81.00.6-0.60.6-0.60.7-0.5-0.5
One hour access (shock baseline)0.20.40.60.70.6-0.70.8-0.6-0.50.7-0.70.80.40.50.40.6-0.60.7-0.70.50.30.3
Social response proportion0.91.01.90.80.5-0.81.0-0.6-1.21.1-1.11.41.21.31.30.5-0.50.7-0.71.0-1.3-0.6
Social responses0.20.22.8-0.1-0.10.0-0.10.1-0.20.0-0.00.10.20.40.20.1-0.10.2-0.2-0.3-1.7-0.8
Social time0.50.61.80.70.5-0.71.0-0.6-1.00.6-0.60.71.31.21.20.3-0.30.3-0.31.10.30.6
Soleus weight0.41.32.31.21.0-1.21.3-1.0-1.31.3-1.31.21.41.11.50.9-0.90.9-0.91.30.80.4
Bone: stiffness2.84.66.82.32.3-2.32.6-2.2-2.52.6-2.62.42.02.22.21.9-1.91.9-1.91.4-1.0-1.6
Tibialis anterior weight0.62.13.51.71.6-1.61.3-1.6-1.21.2-1.21.21.30.81.21.6-1.61.6-1.61.71.91.1
Time to tail flick, vehicle, before self-admin0.10.10.5-0.4-0.30.4-0.50.30.3-0.10.1-0.1-0.2-0.4-0.20.0-0.0-0.10.1-0.4-0.7-0.7
Time to tail flick, vehicle, after self-admin0.40.61.20.70.8-0.71.1-0.8-0.80.7-0.70.90.90.90.80.6-0.60.7-0.70.60.7-0.2
Time to tail flick, test, before self-admin0.20.30.7-0.2-0.20.3-0.30.20.7-0.60.6-0.5-0.6-0.8-0.6-0.40.4-0.50.5-0.40.60.7
Time to tail flick, test, after self-admin0.40.54.30.00.2-0.1-0.0-0.2-0.30.1-0.10.30.00.20.10.5-0.50.2-0.2-0.7-2.1-1.7
Delta time to tail flick, vehicle, before/after SA0.90.81.70.90.9-0.91.0-0.9-1.20.8-0.81.01.11.30.90.8-0.80.9-0.90.2-0.5-1.0
Delta time to tail flick, test, before/after SA0.30.31.80.30.4-0.30.4-0.4-0.60.5-0.50.50.30.80.30.5-0.50.5-0.5-0.1-1.1-1.3
Tibia length0.20.51.6-0.5-0.60.6-0.80.60.9-0.80.8-0.6-0.8-1.3-1.1-0.50.5-0.40.4-0.21.0-0.1
Ambulatory time before self-admin1.01.52.1-1.3-1.31.3-1.21.31.5-1.41.4-1.4-1.1-1.2-1.0-1.31.3-1.41.4-0.80.11.1
Ambulatory time after self-admin1.41.62.5-1.1-1.21.1-1.11.21.3-1.61.6-1.5-1.0-1.1-0.7-1.51.5-1.51.5-0.50.71.6
Bone: tissue strength1.01.01.6-1.2-1.11.1-1.31.11.0-1.01.0-1.1-1.0-0.6-1.0-0.80.8-0.80.8-1.2-1.2-0.4
Total heroin consumption3.64.25.72.12.1-2.11.9-2.1-2.32.1-2.12.42.22.12.22.4-2.42.3-2.31.80.20.2
Bone: trabecular number4.98.110.92.92.8-2.93.1-2.8-3.03.0-3.03.13.13.33.32.9-2.92.9-2.92.80.51.1
Bone: trabecular spacing5.57.39.1-2.8-2.82.8-2.82.82.8-3.03.0-3.0-3.0-2.8-2.9-2.82.8-2.82.8-2.4-0.6-1.0
Bone: trabecular thickness2.83.54.62.12.1-2.12.1-2.0-2.02.1-2.12.02.12.12.11.8-1.81.8-1.81.60.20.1
Bone: trabecular tissue density0.71.01.7-1.1-0.81.1-1.00.81.0-1.01.0-1.3-1.2-1.1-1.2-0.80.8-0.80.8-0.9-0.5-1.3
Water consumed over 24 hours0.10.11.6-0.2-0.20.2-0.50.2-0.10.1-0.10.10.10.10.20.2-0.20.3-0.3-0.1-1.3-0.4
Number of responses in last shaping day2.12.33.1-1.5-1.51.5-1.61.51.6-1.71.7-1.6-1.6-1.6-1.7-1.61.6-1.71.7-1.6-0.3-0.4