Kcnh6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	gene expression	Kcnh6	0.64	0.14	1.3e-06	0.25	0.19	0.19	0.21	8.9e-05	6.7e-04	7.6e-04	3.9e-04
2	Adipose	gene expression	Kcnh6	0.04	0.03	4.9e-03	0.01	0.02	0.02	0.01	1.8e-02	4.0e-03	3.8e-03	7.1e-03
3	Eye	alternative TSS	NM_053937.1	0.35	0.16	1.6e-03	0.13	0.22	0.19	0.18	5.4e-03	2.9e-04	6.5e-04	8.7e-04
4	Eye	alternative TSS	NM_053937.1	0.3	0.16	6.4e-03	0.18	0.15	0.14	0.16	8.9e-04	2.9e-03	3.2e-03	2.1e-03
5	Brain	gene expression	Kcnh6	0.07	0.04	2.9e-04	0.01	0.03	0.04	0.03	2.4e-02	7.7e-04	2.0e-04	9.2e-04
6	PL	gene expression	Kcnh6	0.09	0.04	2.1e-05	0.05	0.04	0.03	0.05	1.4e-06	3.7e-05	1.6e-04	8.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	2.2	3.7	11.4	0.5	2.0	0.2	0.8	2.5	3.4
Area under the delay curve	0.0	0.0	0.1	-0.1	0.3	-0.0	0.2	0.0	-0.2
BMI with tail	1.0	3.3	13.9	-0.3	-1.1	-2.0	0.5	-0.3	-3.7
BMI without tail	1.4	2.9	6.8	1.4	-0.2	-2.6	2.2	0.6	-1.8
Body weight	1.3	5.6	15.1	2.3	1.6	-3.9	2.4	1.6	-1.5
Weight adjusted by age	0.7	0.8	2.4	-0.8	-0.2	0.1	-0.7	-1.2	-1.5
Bone surface	6.3	11.1	21.7	2.4	4.7	-1.8	2.3	4.2	3.6
Bone volume	5.0	8.5	15.4	1.9	3.9	-1.4	2.1	3.7	3.5
Breakpoint value in progressive ratio session	0.9	1.0	2.4	1.5	0.9	-1.0	0.9	-0.1	1.0
Number of licking bursts	0.1	0.1	0.7	0.1	0.9	-0.1	-0.3	0.1	-0.1
Context. condit. distance diff. score	0.6	0.7	2.6	-0.0	-1.0	-0.3	0.2	-0.8	-1.6
Locomotion velocity, session 1	1.2	1.3	3.0	0.8	0.7	-0.3	1.1	1.7	1.6
Locomotion distance, session 1	0.2	0.2	0.5	-0.1	-0.4	0.4	0.7	0.4	0.7
Locomotion velocity, session 2	1.2	1.4	4.6	1.1	1.2	-0.0	0.5	0.8	2.1
Locomotion distance, session 2	0.2	0.2	0.8	0.3	0.1	0.6	0.3	-0.2	0.9
Locomotion velocity, session 3	0.2	0.3	0.6	-0.8	0.1	0.6	-0.6	0.2	0.3
Locomotion distance, session 3	0.3	0.3	0.9	-0.1	0.9	0.1	-0.0	0.6	0.7
Stereotopy head waving bouts, day 3	0.5	0.6	1.3	-1.0	-0.4	1.1	-0.7	0.1	0.6
Stereotopy head waving duration, day 3	0.3	0.4	0.7	-0.8	-0.5	0.8	-0.6	-0.6	-0.2
Locomotion velocity, session 7	0.4	0.4	1.0	-0.8	-1.0	0.8	-0.3	-0.1	0.1
Locomotion distance, session 7	0.3	0.3	1.0	0.2	-0.7	0.2	0.7	-1.0	-0.3
Stereotopy head waving bouts, day 7	0.5	0.6	1.4	-0.7	0.5	1.2	-0.8	0.0	0.9
Stereotopy head waving duration, day 7	1.5	1.8	4.4	-1.3	-0.0	2.1	-1.8	-0.7	1.0
Locomotion velocity, session 8	0.7	0.8	1.9	1.0	0.3	-1.4	0.9	0.7	-0.7
Locomotion distance, session 8	0.3	0.4	0.8	0.5	-0.9	0.1	0.6	-0.9	-0.2
Degree of sensitization distance	0.8	0.8	1.2	0.7	-1.1	-0.5	1.0	-1.1	-1.0
Degree of sensitization stereotypy	0.7	0.8	1.7	-0.8	0.4	1.3	-1.3	-0.2	0.5
Conditioned locomotion	0.6	0.7	1.6	1.1	-0.2	-0.6	1.3	-0.8	0.5
Cocaine response after cond. corrected	0.4	0.4	1.0	-0.8	0.9	-0.0	-0.1	0.4	-1.0
Cocaine response after cond. not corrected	0.8	0.9	2.9	-0.9	1.7	0.4	-0.5	1.1	-0.1
Cocaine response before conditioning	0.7	0.9	2.2	-0.2	0.9	0.9	-0.7	0.9	1.5
Saline control response	1.2	1.6	3.7	1.8	-0.1	-1.6	1.9	-0.2	0.1
Bone: connectivity density	2.8	4.4	12.1	1.1	2.3	-0.1	1.3	2.4	3.5
Bone: cortical apparent density	4.7	6.2	9.6	-2.8	-3.1	3.1	-2.0	-2.5	-0.3
Bone: cortical area	2.0	3.0	6.8	0.7	2.6	-1.2	0.9	2.5	1.5
Bone: cortical porosity	12.1	13.2	26.2	2.9	4.8	-3.5	2.0	5.1	2.3
Bone: cortical porosity	7.8	8.5	17.9	1.9	4.2	-2.9	1.4	4.2	1.4
Bone: cortical thickness	2.7	4.4	12.4	-3.5	-1.0	2.5	-2.6	0.2	0.1
Bone: cortical thickness	2.5	2.9	5.9	-2.4	-1.3	2.3	-2.1	0.0	0.5
Bone: cortical tissue density	4.6	6.0	9.7	-2.7	-3.1	3.0	-1.9	-2.5	-0.3
Condit. Reinf. active minus inactive responses	2.5	2.8	4.5	2.1	1.6	-1.6	1.9	1.3	1.3
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.3	1.5	1.3	-1.0	1.2	1.0	0.8
Condit. Reinf. active responses	2.7	3.3	5.7	2.4	1.5	-1.7	2.2	1.0	1.7
Condit. Reinf. inactive responses	0.7	0.8	1.7	1.1	0.4	-0.6	1.2	0.1	1.3
Incentive salience index mean	2.7	3.2	4.9	1.9	1.9	-1.2	1.6	1.8	2.2
Condit. Reinf. lever presses	0.9	1.2	4.9	0.8	0.9	-0.0	0.2	0.9	2.2
Condit. Reinf. active minus inactive responses	5.2	6.4	8.8	2.9	3.0	-1.6	2.0	2.4	2.9
Condit. Reinf. active-inactive response ratio	4.5	4.7	7.4	2.2	2.5	-1.2	1.6	2.4	2.7
Condit. Reinf. active responses	4.5	6.3	10.6	3.3	2.5	-2.0	2.5	1.8	2.7
Condit. Reinf. inactive responses	1.0	1.2	2.9	1.7	0.2	-1.1	1.5	-0.4	1.0
Condit. Reinf. lever presses	1.4	1.9	3.0	1.7	1.2	-1.1	1.1	1.3	1.6
Condit. Reinf. lever reinforcers received	3.9	5.5	8.7	3.0	2.4	-1.9	2.3	1.8	2.6
Conditioned reinforcement - actives	0.6	0.6	1.4	0.8	-0.4	-1.2	1.0	0.2	-0.5
Conditioned reinforcement - inactives	0.8	0.9	1.6	0.9	0.6	-1.3	1.1	1.1	0.1
Conditioned locomotion	1.6	1.9	3.6	1.7	0.3	-1.9	1.8	1.4	0.3
Patch foraging indifference point 0 sec	2.4	3.9	8.1	2.7	1.2	-1.8	2.8	0.6	1.8
Patch foraging indifference point AUC	0.8	0.9	3.6	0.9	0.1	-1.1	1.9	-0.0	-0.1
Delay disc. indifference point, 0s delay	0.7	0.8	1.9	-0.9	-0.5	1.1	-0.8	-1.4	-0.0
Delay disc. indifference point, 16s delay	0.3	0.3	0.5	0.2	0.7	-0.7	0.6	0.3	-0.4
Delay disc. indifference point, 2s delay	0.3	0.4	1.5	0.2	0.4	0.6	0.4	-0.2	1.2
Delay disc. indifference point, 24s delay	1.0	1.0	2.6	1.0	0.3	-1.5	1.6	0.2	-0.3
Delay disc. indifference point, 4s delay	0.5	0.5	1.3	-1.1	0.2	0.8	-1.1	0.3	-0.3
Delay disc. indifference point, 8s delay	0.3	0.3	0.8	-0.8	-0.3	0.9	-0.3	-0.2	0.1
Indifference point function ln k	0.7	0.9	3.2	-0.5	0.1	0.9	-1.8	0.1	1.1
Indifference point function log k	0.7	0.9	3.2	-0.5	0.1	0.9	-1.8	0.1	1.1
Patch foraging total patch changes 0 sec	2.6	4.2	8.4	2.7	1.4	-2.0	2.9	0.8	1.7
Patch foraging total patch changes 12 sec	3.6	4.7	13.5	2.8	1.1	-1.8	3.7	-0.1	1.4
Patch foraging total patch changes 18 sec	2.4	3.1	7.1	2.1	1.5	-2.1	2.7	0.8	0.4
Patch foraging total patch changes 24 sec	2.3	2.8	5.9	1.9	1.2	-1.4	2.4	1.1	1.6
Patch foraging total patch changes 6 sec	1.7	2.5	4.4	1.8	1.5	-1.5	2.1	1.3	1.1
Patch foraging time to switch 0 sec	0.1	0.1	0.3	-0.3	0.1	0.3	-0.3	0.6	0.3
Patch foraging water rate 0 sec	0.7	1.2	2.8	1.2	0.3	-1.4	1.7	0.8	0.4
Patch foraging water rate 12 sec	0.9	1.4	3.6	-1.6	0.4	0.9	-1.9	0.5	-0.9
Patch foraging water rate 18 sec	0.5	0.6	1.2	-0.7	0.9	1.0	-0.4	0.5	1.1
Patch foraging water rate 24 sec	0.1	0.1	0.4	-0.2	0.6	0.2	-0.4	-0.2	-0.1
Patch foraging water rate 6 sec	0.3	0.5	1.0	-0.7	0.1	0.6	-1.0	0.8	0.7
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.1	0.2	-1.1	-0.7	0.4	-0.5	-0.8
Distance traveled before self-admin	1.2	1.3	3.9	-0.3	2.0	-0.5	-1.0	1.2	-1.2
Distance traveled after self-admin	1.0	1.1	3.6	0.2	1.9	-0.8	-0.4	0.7	-1.4
Extensor digitorum longus weight	2.4	9.3	24.5	-1.6	-4.2	-0.5	-0.9	-3.3	-4.9
Bone: elastic displacement	1.1	1.2	3.4	-1.8	-0.5	1.2	-1.2	0.6	-0.3
Bone: elastic work	0.7	0.9	4.1	-0.7	0.3	0.0	-0.5	2.0	0.7
Bone: endosteal estimation	11.9	25.9	38.3	6.2	5.6	-5.4	5.0	4.6	3.1
Bone: endosteal perimeter	13.9	28.7	44.1	6.1	6.6	-6.1	5.1	4.9	2.1
Epididymis fat weight	0.7	1.5	3.9	1.0	0.0	-1.9	2.0	0.6	-0.7
Delta time in closed arm before/after self-admin	0.5	0.5	1.5	-0.1	1.0	0.3	-0.5	1.2	0.4
Delta time in open arm before/after self-admin	1.9	1.8	5.6	-0.2	-2.2	0.3	0.0	-2.4	-0.4
Diff in mean of infusions in LGA sessions	0.7	0.8	1.2	-0.9	-1.1	0.4	-1.1	-0.6	-1.0
Delay discount exponential model param	0.1	0.1	0.2	-0.1	-0.5	0.3	-0.4	-0.2	0.1
Extinction: sum of active levers before priming	0.7	0.7	2.3	0.9	0.1	-0.7	0.6	-1.5	-0.2
Active lever presses in extinction session 6	2.3	2.3	3.6	1.6	1.6	-1.9	1.9	0.9	0.6
Bone: final force	1.2	1.9	5.2	0.1	2.3	-0.3	0.2	2.1	1.3
Bone: final moment	1.4	2.3	5.8	0.1	2.4	-0.3	0.2	2.4	1.5
Food consumed during 24 hour testing period	1.9	2.3	5.6	2.1	0.4	-2.4	1.7	0.8	-0.1
Glucose	0.6	0.9	2.2	-1.1	-0.5	0.3	-1.0	-0.8	-1.5
Heart weight	0.4	0.6	2.7	-0.1	0.4	-0.8	0.3	-0.3	-1.6
Delay discount hyperbolic model param	0.0	0.0	0.1	0.1	-0.2	-0.1	-0.3	-0.0	-0.1
Intermittent access intake day 1-15 change	0.6	0.6	1.5	0.8	0.8	-1.2	0.5	0.5	-0.5
Intermittent access intake escalation	0.2	0.2	0.5	0.4	0.2	-0.7	0.1	0.1	-0.4
Intermittent access intake escalation 2	0.6	0.6	1.3	1.0	0.5	-1.1	0.7	0.6	-0.1
Intermitt. access day 1 inactive lever presses	4.3	4.6	6.4	2.3	2.5	-1.6	2.1	1.9	2.3
Intermitt. access day 15 inactive lever presses	2.2	2.5	3.4	1.6	0.8	-1.4	1.8	1.7	1.8
Intermitt. access escalation Index	2.1	1.9	3.5	-1.7	0.1	1.3	-1.9	-1.1	-1.4
Intermittent access day 1 total infusions	0.4	0.5	1.2	0.8	0.1	-1.1	0.9	0.5	-0.2
Intermittent access day 15 total infusions	0.7	0.7	2.1	0.9	-0.3	-1.4	0.8	0.2	-0.9
Intermittent access terminal intake (last 3 days)	1.7	1.8	4.1	1.8	0.2	-2.0	1.7	0.8	-0.0
Intermittent access total infusions	1.7	1.9	3.7	1.8	0.3	-1.9	1.8	1.0	0.3
Intermittent access day 1 locomotion	2.7	2.9	5.1	1.9	1.1	-2.3	1.8	2.0	0.0
Intermittent access day 15 total locomotion	3.3	3.5	6.4	2.4	0.8	-2.5	2.4	1.7	0.3
Intermittent access total locomotion	5.0	5.7	9.0	2.9	1.1	-3.0	3.0	2.4	0.9
Intermittent access standard deviation	1.1	1.2	2.0	1.3	0.4	-1.4	1.2	1.3	0.7
Left kidney weight	0.4	1.1	2.5	-1.6	-0.1	0.7	-1.1	-0.5	-1.4
Right kidney weight	0.2	0.5	1.2	-1.1	0.3	0.8	-0.8	0.3	-0.3
Cocaine induced anxiety	0.5	0.5	1.9	-0.7	0.6	0.3	-0.6	1.4	0.1
Post-drug Anxiety	0.6	0.7	1.7	-0.9	0.8	0.2	-0.8	1.3	-0.5
Baseline Anxiety	0.6	0.6	1.2	-1.1	-0.5	0.8	-1.0	-0.5	-0.8
Tail length	1.5	4.4	7.4	2.7	1.5	-2.1	2.5	1.8	1.6
Length with tail	1.3	4.8	6.7	2.4	2.6	-2.2	2.0	2.2	1.7
Length without tail	0.4	0.8	2.2	0.3	1.5	-0.3	0.1	1.0	1.1
Times rat made contact with spout	0.6	0.7	1.3	1.0	0.6	-1.0	0.4	1.1	0.3
Lifetime Intake	2.0	2.3	4.1	2.0	0.4	-1.9	2.0	0.9	0.9
Liver weight, left	0.5	0.8	2.9	1.0	0.7	-0.1	0.7	0.4	1.7
Liver weight, right	0.8	1.3	2.8	-1.7	-0.4	1.6	-1.4	-0.2	0.2
Locomotor activity	0.5	0.8	2.1	1.4	1.1	-0.7	0.8	0.3	0.5
Locomotor testing distance	1.4	2.3	5.7	2.4	1.2	-1.8	1.5	0.8	0.5
Locomotor testing rearing	1.5	2.3	6.3	2.5	1.1	-1.9	1.4	1.0	0.3
Locomotion in novel chamber	0.6	0.7	1.4	-0.5	1.0	-0.3	-0.5	1.2	-1.2
Locomotion in novel chamber post-restriction	1.0	1.2	2.2	1.2	1.5	-1.0	1.2	0.9	0.7
Fecal boli incidents, locomotor time 1	0.4	0.4	0.9	0.2	0.7	-0.7	0.2	-0.7	-1.0
Change in fecal boli incidents, locomotor task	0.5	0.5	1.0	-0.9	-0.9	0.2	-0.4	-0.4	-1.0
Time >=10cm from walls, locomotor time 1	1.6	1.6	3.9	-1.6	0.0	1.2	-2.0	-0.5	-1.3
Bouts of movement, locomotor time 1	0.4	0.4	1.4	-0.7	-1.2	0.5	-0.3	-0.4	-0.1
Total resting periods, locomotor time 1	0.5	0.6	1.7	-0.9	-1.3	0.7	-0.5	-0.4	-0.1
Rest time, locomotor task time 1	0.4	0.5	1.1	-0.4	-0.5	1.0	-0.4	-0.5	1.0
Distance moved, locomotor task time 1	0.5	0.5	1.6	0.4	0.1	-0.9	0.7	1.3	-0.1
Vertical activity count, locomotor time 1	0.4	0.4	1.7	0.1	0.3	-0.7	0.3	1.3	0.1
Time >=10cm from walls, locomotor time 2	0.6	0.6	2.3	-0.1	0.9	0.1	-0.9	1.5	0.1
Bouts of movement, locomotor time 2	0.2	0.2	0.5	-0.5	-0.7	0.0	-0.1	-0.7	-0.5
Total resting periods, locomotor time 2	0.3	0.4	0.7	-0.7	-0.6	0.3	-0.4	-0.8	-0.5
Rest time, locomotor task time 2	2.6	3.0	5.1	-1.9	-0.6	1.8	-1.9	-2.2	-1.4
Distance moved, locomotor task time 2	0.9	1.1	4.3	0.5	-0.1	-0.7	0.5	2.1	1.1
Vertical activity count, locomotor time 2	2.7	2.9	4.7	1.8	0.2	-1.5	1.6	2.2	2.1
Light reinforcement 1	0.4	0.7	1.8	0.4	-0.9	0.2	0.9	-0.9	1.3
Light reinforcement 2	0.6	0.8	3.4	0.4	-0.6	0.3	0.7	-0.3	1.8
Bone: marrow area	11.7	25.3	37.3	6.1	5.6	-5.4	4.9	4.6	3.0
Bone: maximum diameter	4.9	9.0	19.7	2.6	4.4	-2.7	2.3	3.3	2.1
Bone: maximum force	1.4	2.4	5.8	0.9	2.4	-1.2	1.1	2.0	1.1
Bone: maximum moment	1.6	2.7	6.2	0.8	2.5	-1.2	1.0	2.3	1.3
Mean time between licks in bursts	0.5	0.7	2.7	-0.0	0.4	-1.0	0.4	-0.1	-1.6
Mean num. licks in bursts	0.2	0.3	0.6	0.4	-0.8	-0.6	0.7	0.3	-0.1
Cd content in liver	3.0	3.3	4.6	-1.7	-2.1	1.6	-1.4	-2.0	-2.0
Co content in liver	0.3	0.3	1.2	-0.2	-0.1	0.0	-0.1	-0.7	-1.1
Cu content in liver	0.3	0.3	1.3	0.6	-0.2	-0.2	0.6	0.2	1.1
Fe content in liver	0.6	0.7	1.3	-0.1	-1.1	1.0	-0.8	-1.0	0.7
K content in liver	1.1	1.1	3.4	0.9	1.4	-0.1	0.8	0.1	1.8
Mg content in liver	1.0	1.1	3.8	0.3	-0.4	1.0	0.3	-1.1	1.9
Mn content in liver	1.5	1.7	6.9	-0.2	0.3	1.7	-0.0	-0.4	2.6
Na content in liver	0.7	0.7	2.3	1.0	1.0	0.1	0.3	-0.3	1.5
Rb content in liver	2.6	3.3	7.0	-1.8	-1.2	2.6	-1.7	-2.2	0.4
Se content in liver	1.2	1.4	3.2	-1.1	-0.9	1.2	-0.9	-1.8	-1.0
Sr content in liver	0.8	0.8	2.4	0.1	1.2	-0.7	0.4	1.6	-0.1
Zn content in liver	0.4	0.4	1.6	-0.3	1.2	0.4	0.6	0.3	0.4
Bone: minimum diameter	10.6	19.7	26.8	4.7	5.2	-5.0	4.3	4.6	2.1
Time in familiar zone, hab. session 1	0.9	0.8	1.5	1.1	0.1	-1.2	1.2	-0.6	-0.6
Time in novel zone, hab. session 1	1.0	0.9	2.1	-1.3	-0.5	1.2	-1.4	0.4	0.1
Total zone transitions, hab. session 1	0.1	0.2	0.4	0.4	-0.2	-0.5	0.7	0.4	-0.3
Total locomotion distance, hab. session 1	0.7	1.0	2.6	0.5	0.5	-0.3	0.9	1.6	1.5
Locomotion velocity, hab. session 1	0.9	1.3	2.5	0.8	0.7	-0.5	1.2	1.6	1.5
Time in familiar zone, hab. session 2	1.6	1.6	3.3	1.8	1.2	-1.6	1.5	0.0	-0.6
Time in novel zone, hab. session 2	1.8	1.8	3.5	-1.9	-1.0	1.7	-1.5	0.1	0.8
Total zone transitions, hab. session 2	0.1	0.1	0.4	0.5	-0.3	-0.1	0.7	-0.3	-0.0
Total locomotion distance, hab. session 2	0.5	0.7	1.7	0.6	-0.9	0.1	1.3	-0.2	1.1
Locomotion velocity, hab. session 2	0.5	0.6	1.6	0.4	-0.9	0.2	1.3	-0.3	1.0
Novel to familiar place preference ratio	0.3	0.3	0.8	0.1	0.7	-0.7	0.3	0.9	-0.1
Novelty place preference	0.2	0.2	0.6	-0.1	0.6	-0.4	0.1	0.7	-0.1
Time in novel zone, NPP test	0.2	0.2	0.6	-0.1	0.7	-0.3	-0.1	0.8	0.0
Total zone transitions, NPP test	0.2	0.3	0.5	0.1	-0.6	0.6	0.7	-0.3	0.7
Total locomotion distance, NPP test	0.6	0.9	3.0	0.5	-0.2	0.3	1.1	0.7	1.7
Locomotion velocity, NPP test	0.4	0.5	1.5	0.4	-0.7	0.1	1.2	0.0	1.0
Intraocular pressure	0.9	1.2	3.8	0.8	-0.2	-1.9	1.0	-0.2	-1.4
Delta distance traveled before/after self-admin	0.1	0.1	0.4	-0.2	-0.3	0.4	-0.4	-0.6	-0.1
Delta ambulatory time before/after self-admin	0.1	0.1	0.4	0.1	-0.1	0.3	0.2	-0.6	0.5
Parametrial fat weight	0.7	1.4	3.2	0.7	0.5	-0.5	1.2	1.7	1.8
Pavlov. Cond. lever latency	2.6	3.3	6.5	-1.3	-2.0	1.0	-1.0	-2.4	-2.6
Pavlov. Cond. magazine entry latency	3.6	4.7	8.6	2.1	2.2	-1.4	1.8	2.2	2.9
Pavlov. Cond. change in total contacts	3.4	3.6	7.9	1.7	1.5	-1.2	1.6	2.1	2.8
Pavlov. Cond. index score	3.2	4.1	7.8	1.9	2.2	-1.3	1.5	2.2	2.8
Pavlov. Cond. latency score	2.7	3.4	5.8	1.7	2.1	-1.3	1.3	2.0	2.4
Pavlov. Cond. lever contacts	2.3	2.7	4.9	1.3	1.7	-1.2	0.9	2.2	2.0
Pavlov. Cond. magazine entry number	2.9	3.7	9.4	-1.7	-1.7	0.9	-1.6	-1.9	-3.1
Pavlov. Cond. intertrial magazine entries	1.1	1.3	3.4	1.3	-0.1	-1.3	1.8	-1.1	-0.6
Pavlov. Cond. lever-magazine prob. diff.	3.1	3.8	6.8	1.7	2.2	-1.3	1.3	2.3	2.6
Pavlov. Cond. response bias	4.4	5.3	12.9	1.8	2.3	-1.0	1.5	2.7	3.6
Pavlov. Cond. lever latency	0.4	0.5	1.3	-0.8	-1.1	0.4	-0.5	-0.4	-0.7
Pavlov. Cond. magazine entry latency	1.5	1.8	3.1	-1.6	-0.2	1.3	-1.8	-1.2	-1.4
Pavlov. Cond. change in total contacts	0.3	0.4	1.2	1.1	0.7	-0.4	0.7	-0.2	0.3
Pavlov. Cond. index score	0.2	0.2	1.1	0.1	1.0	0.0	-0.4	0.1	-0.2
Pavlov. Cond. latency score	0.2	0.3	1.5	0.0	1.2	0.1	-0.4	0.2	-0.2
Pavlov. Cond. lever contacts	0.2	0.2	0.4	0.6	0.7	-0.2	0.4	0.3	0.6
Pavlov. Cond. magazine entry number	1.9	2.3	4.0	1.9	0.2	-1.7	2.0	1.1	1.4
Pavlov. Cond. intertrial magazine entries	8.5	11.1	18.1	4.1	1.8	-4.0	4.3	2.6	2.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.9	-0.0	0.9	0.2	-0.5	-0.1	-0.2
Pavlov. Cond. response bias	0.0	0.0	0.2	0.1	0.4	0.2	-0.1	-0.1	0.1
Time in closed arm before self-admin	0.6	0.7	1.5	-0.9	-0.4	1.2	-1.2	0.3	0.3
Time in closed arm after self-admin	0.8	0.8	2.1	-0.8	0.5	1.2	-1.4	0.7	-0.1
Time in open arm before self-admin	0.8	0.9	2.1	-0.9	0.9	-0.2	-1.0	0.9	-1.4
Time in open arm after self-admin	0.8	0.9	1.8	0.3	-0.6	-1.3	0.7	-0.9	-1.4
Bone: periosteal estimation	8.6	17.7	27.9	4.2	5.3	-4.0	3.7	4.6	3.1
Bone: periosteal perimeter	6.1	10.1	24.3	2.4	4.9	-3.0	1.9	4.0	1.4
Bone: post-yield work	2.5	3.4	6.4	1.7	2.5	-2.3	1.6	1.9	-0.0
Progressive ratio test 1 active lever presses	3.0	3.1	5.0	2.2	1.5	-2.0	2.2	1.2	1.0
Progressive ratio test 1 breakpoint	3.9	4.0	7.0	2.6	1.5	-2.4	2.6	1.2	1.0
Progressive ratio test 1 inactive lever presses	3.1	3.4	5.9	2.4	1.6	-2.0	2.4	0.9	1.3
Progressive ratio test 2 active lever presses	3.2	3.4	6.4	2.2	1.2	-2.2	2.5	1.5	0.9
Progressive ratio test 2 breakpoint	4.2	4.7	7.2	2.6	1.8	-2.7	2.7	1.9	0.8
Progressive ratio test 2 inactive lever presses	2.4	2.8	6.5	2.0	0.4	-2.1	2.5	1.0	0.9
Incentive Sensitization - Responses	2.3	2.4	4.2	1.8	1.2	-1.9	2.0	1.2	0.4
Incentive Sensitization - Breakpoint	2.2	2.3	3.7	1.7	1.3	-1.9	1.9	1.3	0.3
Sum of active levers in priming session hrs 5-6	1.1	1.1	5.6	0.2	-0.8	0.2	-0.2	-2.4	-0.1
Progressive ratio	0.2	0.2	0.7	-0.4	0.8	0.2	-0.2	0.0	-0.4
Food seeking constrained by brief footshock	2.6	3.2	5.7	2.4	1.6	-2.1	2.2	1.2	0.6
Seeking ratio, punishment vs. effort	1.0	1.3	2.6	1.6	0.2	-1.4	1.4	0.7	0.7
Retroperitoneal fat weight	0.9	3.0	7.9	1.8	0.6	-1.9	2.8	1.4	0.7
Reaction time number correct	0.7	0.9	1.5	-1.2	-0.5	0.8	-1.2	-0.8	-1.1
Reaction time mean minus median	0.3	0.4	0.9	-0.6	-1.0	0.4	-0.7	-0.5	-0.2
Reaction time mean minus median AUC	1.1	1.4	2.1	-1.3	-1.3	1.4	-1.5	-1.1	-0.3
Reaction time num false alarms	2.6	3.5	6.0	2.1	2.5	-2.1	1.8	1.3	1.0
Reaction time num false alarms AUC	2.7	3.7	5.1	2.2	2.3	-2.0	2.2	1.3	1.5
Reaction time trials correct on left	0.7	0.9	1.5	-1.2	-0.5	0.8	-1.2	-0.8	-1.1
Reaction time trials on left	0.6	0.9	1.4	-1.2	-0.5	0.8	-1.2	-0.7	-1.1
Reaction time mean	0.8	1.1	2.5	-1.0	-0.7	1.6	-1.1	-0.7	0.9
Reaction time mean AUC	1.0	1.3	2.9	-0.9	-0.9	1.7	-1.1	-0.9	0.9
Median of all reaction times	0.8	1.2	3.0	-0.9	-0.6	1.7	-1.0	-0.6	1.1
Reaction time omissions	0.2	0.3	1.2	-0.4	-0.3	0.6	0.0	0.3	1.1
Reaction time false alarm rate	3.2	4.5	5.7	2.4	2.3	-2.1	2.4	1.6	1.8
Reaction time premature initiation rate	0.6	0.8	1.3	1.0	0.1	-1.1	1.1	1.0	0.0
Reaction time premature initiations	0.2	0.2	0.4	0.4	-0.2	-0.6	0.6	0.4	-0.6
Std. dev. reaction times	0.4	0.6	1.0	-0.8	-1.0	1.0	-0.7	-0.6	0.5
Reaction time trials completed	0.6	0.9	1.4	-1.2	-0.5	0.8	-1.2	-0.7	-1.1
Reaction time trials AUC	0.7	1.0	1.5	-1.2	-0.6	0.9	-1.2	-0.8	-1.2
Run reversals in cocaine runway, females	0.6	0.6	1.0	-0.8	-1.0	-0.3	-0.5	1.0	-0.8
Run reversals in cocaine runway, males	0.3	0.3	1.0	-0.5	1.0	-0.2	-0.3	0.4	-0.7
Latency to leave start box in cocaine runway	0.3	0.3	0.8	-0.6	-0.5	0.3	-0.9	-0.1	-0.6
Latency to leave start box in cocaine runway, F	0.7	0.8	1.6	-1.1	0.6	0.3	-1.3	0.5	-1.0
Latency to leave start box in cocaine runway, M	0.8	0.8	3.4	0.3	-1.8	0.4	-0.1	-1.0	0.4
Std. dev. time between licks in bursts	0.1	0.1	0.3	0.1	-0.6	-0.2	-0.2	-0.5	-0.4
Total sessions with >9 infusions	0.1	0.1	0.3	0.3	-0.5	-0.2	0.5	-0.4	0.1
Short access day 1 total inactive lever presses	1.1	1.3	2.8	0.9	1.5	-1.0	0.7	1.7	0.4
Short access day 10 total inactive lever presses	0.6	0.7	1.1	0.9	0.9	-0.9	1.0	-0.3	0.6
Short access day 1 total infusions	0.6	0.6	1.4	1.1	0.0	-0.9	1.2	-0.3	0.4
Short access day 10 total infusions	4.1	4.5	7.8	2.8	1.2	-2.7	2.7	1.4	1.2
Short access total infusions	2.3	2.6	5.1	2.3	0.9	-1.9	2.0	0.9	1.3
Short access day 1 locomotion	2.0	2.2	4.8	1.8	0.2	-2.2	2.1	0.9	0.0
Short access day 10 total locomotion	7.3	8.2	13.5	3.6	1.7	-3.7	3.6	2.4	1.0
Short access total locomotion	3.7	3.9	7.6	2.5	0.8	-2.8	2.4	1.6	0.3
One hour access (0.3 mA shock)	1.0	1.1	2.3	1.5	1.0	-1.5	1.1	0.5	-0.0
Compulsive drug intake	1.1	1.1	2.1	-1.4	0.8	1.0	-1.4	0.7	-0.7
One hour access (shock baseline)	1.2	1.4	3.0	1.7	-0.4	-1.6	1.6	-0.3	0.3
Social response proportion	0.7	0.7	3.4	-0.4	-0.1	-0.6	0.2	-0.7	-1.8
Social responses	0.2	0.3	0.7	0.3	0.4	-0.7	0.8	-0.4	-0.5
Social time	0.8	1.1	1.8	0.4	1.2	-1.4	1.0	0.5	-1.4
Soleus weight	0.2	0.7	1.3	0.4	1.0	-1.1	-0.1	1.1	-0.5
Bone: stiffness	0.5	0.8	2.9	0.9	1.7	-0.5	0.8	0.2	0.5
Tibialis anterior weight	0.6	2.1	4.1	0.6	-1.8	-1.9	1.0	-0.4	-2.0
Time to tail flick, vehicle, before self-admin	0.4	0.4	1.0	-0.7	1.0	0.2	-0.8	0.5	-0.4
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.8	0.7	0.7	-0.5	0.9	-0.2	0.3
Time to tail flick, test, before self-admin	0.4	0.4	1.0	-0.7	-0.4	0.2	-0.7	-0.0	-1.0
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.5	0.2	0.4	-0.4	0.3	0.2
Delta time to tail flick, vehicle, before/after SA	1.5	1.5	3.3	1.6	-0.1	-0.7	1.8	-0.0	1.6
Delta time to tail flick, test, before/after SA	0.2	0.2	0.8	0.0	0.2	0.6	-0.0	-0.5	0.9
Tibia length	0.2	0.6	1.3	-0.9	1.1	0.5	-0.5	1.0	0.1
Ambulatory time before self-admin	1.3	1.3	4.2	-0.0	2.0	-0.7	-0.7	1.2	-1.1
Ambulatory time after self-admin	0.9	1.0	3.9	0.4	2.0	-0.8	-0.0	1.1	-0.6
Bone: tissue strength	0.9	0.9	1.4	-1.2	-0.2	1.2	-1.1	-0.9	-0.7
Total heroin consumption	0.7	0.9	2.5	0.9	1.6	-0.4	0.4	0.6	1.1
Bone: trabecular number	2.7	4.3	11.3	1.1	2.5	-0.1	1.3	2.3	3.4
Bone: trabecular spacing	1.1	1.4	5.0	-0.0	-0.8	-0.3	-0.2	-1.6	-2.2
Bone: trabecular thickness	3.1	3.7	8.6	0.8	2.0	-0.9	1.1	2.9	2.6
Bone: trabecular tissue density	1.2	1.7	3.5	-1.9	-1.0	1.7	-1.2	-1.0	-0.4
Water consumed over 24 hours	0.1	0.1	0.4	-0.0	-0.3	-0.0	-0.3	0.6	0.3
Number of responses in last shaping day	1.4	1.4	2.4	1.0	1.5	-1.5	0.8	1.5	-0.2