Hub : Genes

Kcne3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Kcne3	0.05	0.04	9.7e-05	0.04	0.04	0.04	0.04	5.1e-05	5.0e-05	1.8e-04	1.3e-04
2	NAcc	gene expression	Kcne3	0.02	0.02	2.3e-03	0.02	0.01	0.01	0.01	5.2e-03	8.4e-03	6.1e-02	1.5e-02
3	Adipose	gene expression	Kcne3	0.06	0.04	1.2e-06	0.06	0.04	0.05	0.05	1.0e-06	2.4e-05	7.2e-06	4.8e-06
4	PL	gene expression	Kcne3	0.06	0.04	9.6e-05	0.01	0.03	0.03	0.02	3.2e-02	3.8e-04	5.2e-04	1.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.2	0.5	0.2	-0.1	-0.3	0.7
Area under the delay curve	0.2	0.2	0.2	-0.4	0.5	0.5	-0.4
BMI with tail	0.1	0.3	0.5	-0.4	0.6	0.4	-0.7
BMI without tail	1.2	2.6	5.9	-0.9	1.4	1.2	-2.4
Body weight	1.0	4.3	8.9	-1.3	1.9	1.8	-3.0
Weight adjusted by age	0.3	0.4	1.2	-0.1	0.4	0.4	-1.1
Bone surface	0.3	0.6	1.0	1.0	-0.7	-0.9	0.1
Bone volume	0.2	0.4	0.7	0.8	-0.6	-0.7	0.2
Breakpoint value in progressive ratio session	0.1	0.2	0.5	0.1	-0.3	-0.2	0.7
Number of licking bursts	4.9	5.7	7.5	-2.7	2.6	2.6	-1.3
Context. condit. distance diff. score	3.0	3.6	4.6	2.1	-2.1	-2.0	1.2
Locomotion velocity, session 1	0.3	0.4	1.0	0.3	-0.4	-0.4	1.0
Locomotion distance, session 1	1.2	1.6	1.8	1.3	-1.4	-1.3	1.0
Locomotion velocity, session 2	0.0	0.0	0.0	0.2	-0.0	-0.1	-0.1
Locomotion distance, session 2	0.5	0.7	0.8	0.9	-0.9	-0.9	0.6
Locomotion velocity, session 3	1.4	1.7	1.8	1.3	-1.3	-1.3	1.2
Locomotion distance, session 3	2.5	2.8	3.0	1.7	-1.7	-1.7	1.5
Stereotopy head waving bouts, day 3	0.8	1.0	1.0	-1.0	1.0	1.0	-0.9
Stereotopy head waving duration, day 3	0.2	0.2	0.2	0.4	-0.5	-0.5	0.4
Locomotion velocity, session 7	0.0	0.0	0.1	-0.2	0.0	0.1	0.4
Locomotion distance, session 7	0.1	0.2	0.2	-0.5	0.5	0.4	-0.2
Stereotopy head waving bouts, day 7	2.7	3.1	3.9	2.0	-1.9	-1.9	1.1
Stereotopy head waving duration, day 7	2.5	3.1	4.2	2.0	-2.0	-1.9	0.8
Locomotion velocity, session 8	0.7	0.9	1.1	1.1	-1.0	-1.0	0.5
Locomotion distance, session 8	2.2	3.3	4.4	2.0	-2.1	-1.9	1.0
Degree of sensitization distance	3.6	3.6	4.3	-1.7	1.9	1.9	-2.1
Degree of sensitization stereotypy	5.6	6.1	8.0	2.8	-2.7	-2.7	1.4
Conditioned locomotion	0.1	0.1	0.3	0.1	-0.2	-0.2	0.5
Cocaine response after cond. corrected	2.6	2.9	3.4	-1.9	1.8	1.8	-1.3
Cocaine response after cond. not corrected	0.6	0.6	0.8	-0.9	0.9	0.8	-0.6
Cocaine response before conditioning	3.0	3.7	4.2	2.0	-2.0	-2.1	1.5
Saline control response	0.5	0.6	1.0	1.0	-0.7	-0.7	-0.6
Bone: connectivity density	0.4	0.6	1.1	0.7	-0.6	-0.7	1.1
Bone: cortical apparent density	2.5	3.2	4.0	-2.0	2.0	1.9	-1.2
Bone: cortical area	0.1	0.1	0.4	0.2	0.1	-0.0	-0.6
Bone: cortical porosity	1.9	2.1	2.5	1.5	-1.6	-1.5	1.2
Bone: cortical porosity	1.7	1.9	2.2	1.4	-1.5	-1.4	1.2
Bone: cortical thickness	0.0	0.1	0.1	-0.3	0.3	0.3	0.1
Bone: cortical thickness	0.3	0.3	0.4	0.6	-0.5	-0.6	0.6
Bone: cortical tissue density	2.3	3.1	3.8	-1.9	1.9	1.8	-1.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	-0.2	0.3	0.3	-0.8
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.9	0.0	0.2	0.2	-0.9
Condit. Reinf. active responses	0.1	0.1	0.3	-0.3	0.3	0.3	-0.5
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.0	-0.0	-0.0	0.2
Incentive salience index mean	0.1	0.1	0.4	0.0	0.2	0.1	-0.7
Condit. Reinf. lever presses	0.0	0.0	0.0	0.2	-0.0	-0.1	-0.2
Condit. Reinf. active minus inactive responses	1.9	2.4	4.3	2.1	-1.5	-1.6	-0.8
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.3	1.2	-1.0	-1.0	-0.0
Condit. Reinf. active responses	2.1	2.9	5.1	2.3	-1.6	-1.6	-1.2
Condit. Reinf. inactive responses	1.0	1.2	1.9	1.4	-0.9	-0.9	-1.2
Condit. Reinf. lever presses	7.1	9.6	16.3	4.0	-3.3	-3.3	-0.1
Condit. Reinf. lever reinforcers received	2.7	3.8	6.8	2.6	-1.9	-1.9	-1.0
Conditioned reinforcement - actives	3.6	3.6	4.5	2.1	-2.0	-2.0	1.3
Conditioned reinforcement - inactives	0.2	0.3	0.3	-0.5	0.5	0.5	-0.6
Conditioned locomotion	4.4	5.2	5.9	2.4	-2.4	-2.4	1.8
Patch foraging indifference point 0 sec	2.5	4.0	6.0	2.5	-2.2	-2.2	0.5
Patch foraging indifference point AUC	0.7	0.8	1.5	-0.6	0.9	0.8	-1.2
Delay disc. indifference point, 0s delay	0.2	0.2	0.4	0.6	-0.4	-0.5	-0.2
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	-0.0	-0.0	-0.0	0.3
Delay disc. indifference point, 2s delay	0.2	0.2	0.8	0.1	0.1	0.1	-0.9
Delay disc. indifference point, 24s delay	0.4	0.4	0.6	-0.8	0.7	0.7	0.1
Delay disc. indifference point, 4s delay	0.4	0.4	1.3	-0.0	0.3	0.3	-1.1
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.0	0.1	0.1	-0.1
Indifference point function ln k	2.9	4.0	4.2	2.0	-2.1	-2.1	1.9
Indifference point function log k	2.9	4.0	4.2	2.0	-2.1	-2.1	1.9
Patch foraging total patch changes 0 sec	1.8	3.0	4.5	2.1	-1.9	-1.9	0.3
Patch foraging total patch changes 12 sec	0.3	0.3	1.3	0.3	0.0	-0.0	-1.1
Patch foraging total patch changes 18 sec	0.7	0.9	1.5	1.2	-0.9	-1.0	-0.4
Patch foraging total patch changes 24 sec	0.2	0.3	1.1	0.3	-0.1	-0.1	-1.0
Patch foraging total patch changes 6 sec	0.4	0.6	0.9	0.9	-0.8	-0.8	0.3
Patch foraging time to switch 0 sec	1.4	2.1	3.6	-1.9	1.5	1.6	0.1
Patch foraging water rate 0 sec	2.0	3.2	4.8	2.2	-1.9	-2.0	0.6
Patch foraging water rate 12 sec	2.1	3.2	4.2	2.1	-1.9	-2.0	1.0
Patch foraging water rate 18 sec	0.4	0.6	1.0	1.0	-0.8	-0.8	-0.1
Patch foraging water rate 24 sec	2.3	3.2	3.5	1.8	-1.8	-1.9	1.6
Patch foraging water rate 6 sec	1.4	2.0	2.4	1.6	-1.5	-1.5	1.0
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.4	-0.6	0.2	0.4	0.6
Distance traveled before self-admin	1.2	1.3	1.7	-1.3	1.2	1.3	-0.5
Distance traveled after self-admin	0.7	0.8	2.1	0.4	-0.6	-0.7	1.4
Extensor digitorum longus weight	0.6	2.3	3.1	-1.3	1.6	1.5	-1.8
Bone: elastic displacement	0.5	0.5	0.9	-1.0	0.6	0.6	0.6
Bone: elastic work	0.3	0.4	0.9	-0.7	0.4	0.4	1.0
Bone: endosteal estimation	0.3	0.6	2.0	0.5	0.0	-0.1	-1.4
Bone: endosteal perimeter	0.3	0.6	1.4	0.8	-0.3	-0.4	-1.2
Epididymis fat weight	2.0	4.6	5.5	-1.9	2.1	2.2	-2.4
Delta time in closed arm before/after self-admin	6.0	5.8	6.3	-2.3	2.4	2.5	-2.4
Delta time in open arm before/after self-admin	2.2	2.1	3.1	1.8	-1.6	-1.6	0.3
Diff in mean of infusions in LGA sessions	2.8	3.1	4.4	-2.1	1.8	2.0	-0.8
Delay discount exponential model param	0.2	0.2	0.3	0.4	-0.5	-0.5	0.4
Extinction: sum of active levers before priming	0.1	0.1	0.1	-0.4	0.2	0.3	-0.3
Active lever presses in extinction session 6	5.8	5.7	6.4	2.4	-2.5	-2.4	2.2
Bone: final force	0.0	0.0	0.0	-0.2	0.2	0.2	-0.1
Bone: final moment	0.0	0.0	0.0	-0.0	0.0	0.0	-0.2
Food consumed during 24 hour testing period	3.7	4.5	5.9	2.4	-2.3	-2.3	1.2
Glucose	0.1	0.2	0.2	0.4	-0.3	-0.4	0.5
Heart weight	0.9	1.2	1.9	1.4	-1.2	-1.2	0.4
Delay discount hyperbolic model param	0.2	0.3	0.4	0.4	-0.5	-0.5	0.6
Intermittent access intake day 1-15 change	0.5	0.5	0.8	0.9	-0.7	-0.7	0.4
Intermittent access intake escalation	0.7	0.6	1.0	1.0	-0.8	-0.8	0.5
Intermittent access intake escalation 2	0.1	0.1	0.1	0.1	0.2	0.2	-0.4
Intermitt. access day 1 inactive lever presses	0.5	0.6	0.6	-0.8	0.8	0.8	-0.7
Intermitt. access day 15 inactive lever presses	0.5	0.5	0.6	0.7	-0.8	-0.8	0.6
Intermitt. access escalation Index	0.2	0.2	0.3	0.6	-0.4	-0.4	0.2
Intermittent access day 1 total infusions	0.7	0.8	1.2	1.1	-1.1	-1.1	0.0
Intermittent access day 15 total infusions	1.6	1.7	2.4	1.6	-1.4	-1.4	0.6
Intermittent access terminal intake (last 3 days)	1.0	1.0	1.6	1.3	-1.1	-1.1	0.3
Intermittent access total infusions	0.7	0.8	1.1	1.1	-1.0	-1.0	0.1
Intermittent access day 1 locomotion	0.4	0.4	0.6	0.6	-0.7	-0.7	0.5
Intermittent access day 15 total locomotion	1.5	1.6	2.1	1.4	-1.4	-1.4	0.8
Intermittent access total locomotion	0.7	0.7	1.0	1.0	-1.0	-1.0	0.3
Intermittent access standard deviation	0.1	0.1	0.2	-0.0	0.2	0.2	-0.4
Left kidney weight	0.4	1.2	4.2	-0.1	0.6	0.6	-2.1
Right kidney weight	0.3	0.9	2.9	-0.2	0.6	0.7	-1.7
Cocaine induced anxiety	1.1	1.3	2.1	-1.4	1.3	1.3	-0.2
Post-drug Anxiety	1.2	1.4	1.7	-1.3	1.3	1.3	-0.7
Baseline Anxiety	0.3	0.3	0.5	0.7	-0.5	-0.5	-0.3
Tail length	1.7	5.2	15.5	-0.7	1.6	1.5	-3.9
Length with tail	1.4	5.2	12.7	-1.2	1.8	1.8	-3.6
Length without tail	0.1	0.2	0.3	-0.5	0.4	0.5	-0.0
Times rat made contact with spout	1.2	1.4	1.5	-1.1	1.2	1.2	-1.2
Lifetime Intake	1.0	1.1	1.6	1.2	-1.2	-1.2	0.2
Liver weight, left	2.2	3.5	3.9	-1.7	1.8	1.9	-2.0
Liver weight, right	4.8	7.9	8.4	-2.7	2.8	2.8	-2.9
Locomotor activity	0.4	0.7	1.1	1.0	-0.8	-0.9	0.5
Locomotor testing distance	0.7	1.1	2.0	1.4	-1.1	-1.1	-0.1
Locomotor testing rearing	0.3	0.4	1.5	0.0	0.3	0.3	-1.2
Locomotion in novel chamber	1.8	2.2	2.4	1.4	-1.5	-1.4	1.5
Locomotion in novel chamber post-restriction	3.0	3.6	4.4	2.0	-2.1	-2.1	1.3
Fecal boli incidents, locomotor time 1	1.7	1.8	2.0	1.4	-1.4	-1.4	1.2
Change in fecal boli incidents, locomotor task	1.0	1.0	1.3	-1.1	1.1	1.1	-0.5
Time >=10cm from walls, locomotor time 1	2.4	2.4	2.9	1.7	-1.7	-1.7	1.0
Bouts of movement, locomotor time 1	0.3	0.3	0.4	0.6	-0.6	-0.6	0.4
Total resting periods, locomotor time 1	0.7	0.8	0.9	0.8	-0.9	-0.9	0.9
Rest time, locomotor task time 1	0.3	0.3	0.7	0.3	-0.5	-0.5	0.8
Distance moved, locomotor task time 1	0.8	0.8	1.6	-0.5	0.8	0.8	-1.3
Vertical activity count, locomotor time 1	0.2	0.2	0.8	-0.1	0.3	0.3	-0.9
Time >=10cm from walls, locomotor time 2	0.7	0.7	1.2	1.1	-1.0	-1.0	0.0
Bouts of movement, locomotor time 2	0.5	0.5	1.3	-0.3	0.6	0.6	-1.1
Total resting periods, locomotor time 2	0.6	0.7	1.2	-0.6	0.8	0.8	-1.1
Rest time, locomotor task time 2	1.3	1.4	2.6	-1.6	1.3	1.3	-0.0
Distance moved, locomotor task time 2	0.9	1.1	2.1	1.4	-1.0	-1.0	-0.4
Vertical activity count, locomotor time 2	0.2	0.3	0.8	0.5	-0.2	-0.2	-0.9
Light reinforcement 1	1.5	2.7	4.2	-2.1	1.8	1.7	-0.6
Light reinforcement 2	0.1	0.1	0.4	-0.1	-0.1	-0.1	0.7
Bone: marrow area	0.3	0.6	2.2	0.3	0.2	0.0	-1.5
Bone: maximum diameter	0.3	0.6	1.0	1.0	-0.6	-0.7	-0.8
Bone: maximum force	0.0	0.0	0.0	0.1	-0.0	-0.0	-0.1
Bone: maximum moment	0.0	0.0	0.1	0.3	-0.2	-0.2	-0.1
Mean time between licks in bursts	0.9	1.3	4.0	0.9	-0.3	-0.4	-2.0
Mean num. licks in bursts	3.4	4.1	5.7	2.4	-2.2	-2.2	0.9
Cd content in liver	1.3	1.4	1.7	-1.2	1.3	1.1	-1.1
Co content in liver	0.3	0.3	0.8	0.5	-0.3	-0.3	-0.9
Cu content in liver	0.3	0.3	1.3	0.1	0.2	0.1	-1.1
Fe content in liver	0.1	0.1	0.1	-0.3	0.3	0.3	-0.3
K content in liver	0.6	0.6	0.7	-0.8	0.8	0.8	-0.8
Mg content in liver	0.0	0.0	0.0	0.2	-0.1	-0.1	-0.2
Mn content in liver	0.3	0.3	1.2	-0.4	0.1	0.2	1.1
Na content in liver	0.3	0.3	0.5	0.6	-0.7	-0.6	0.4
Rb content in liver	0.2	0.3	0.5	0.7	-0.5	-0.5	-0.2
Se content in liver	1.3	1.6	2.7	-1.6	1.3	1.4	0.1
Sr content in liver	0.4	0.3	0.6	0.4	-0.6	-0.5	0.8
Zn content in liver	2.3	2.6	4.2	2.0	-1.7	-1.7	0.2
Bone: minimum diameter	0.9	1.7	4.3	-0.7	1.1	1.0	-2.1
Time in familiar zone, hab. session 1	0.2	0.2	0.4	-0.3	0.4	0.4	-0.6
Time in novel zone, hab. session 1	0.2	0.2	0.3	-0.5	0.4	0.5	-0.1
Total zone transitions, hab. session 1	0.5	0.7	1.2	0.6	-0.8	-0.7	1.1
Total locomotion distance, hab. session 1	2.2	3.1	3.3	-1.7	1.8	1.8	-1.8
Locomotion velocity, hab. session 1	1.3	1.8	1.9	-1.3	1.3	1.4	-1.4
Time in familiar zone, hab. session 2	0.5	0.5	0.9	0.9	-0.8	-0.7	-0.2
Time in novel zone, hab. session 2	0.1	0.1	0.2	-0.2	0.2	0.1	0.4
Total zone transitions, hab. session 2	2.1	2.7	3.2	1.7	-1.8	-1.7	1.2
Total locomotion distance, hab. session 2	1.0	1.3	2.6	-0.8	1.0	1.0	-1.6
Locomotion velocity, hab. session 2	1.5	2.0	3.4	-1.1	1.2	1.3	-1.8
Novel to familiar place preference ratio	0.1	0.1	0.1	0.3	-0.3	-0.3	0.2
Novelty place preference	0.1	0.1	0.1	0.3	-0.3	-0.3	0.2
Time in novel zone, NPP test	0.2	0.2	0.3	0.5	-0.5	-0.5	0.3
Total zone transitions, NPP test	0.6	0.9	1.0	0.9	-1.0	-0.9	0.9
Total locomotion distance, NPP test	1.5	2.0	2.4	-1.3	1.4	1.4	-1.5
Locomotion velocity, NPP test	1.8	2.6	2.8	-1.6	1.6	1.7	-1.6
Intraocular pressure	0.7	1.0	1.2	0.9	-1.0	-1.0	1.1
Delta distance traveled before/after self-admin	2.6	2.8	3.5	1.7	-1.8	-1.9	1.3
Delta ambulatory time before/after self-admin	3.3	3.7	4.5	1.9	-2.0	-2.1	1.7
Parametrial fat weight	1.9	3.8	3.9	-2.0	2.0	2.0	-1.8
Pavlov. Cond. lever latency	0.5	0.6	1.1	-1.1	0.8	0.9	0.0
Pavlov. Cond. magazine entry latency	1.1	1.4	2.4	1.6	-1.3	-1.3	-0.2
Pavlov. Cond. change in total contacts	0.5	0.6	0.9	1.0	-0.8	-0.8	-0.2
Pavlov. Cond. index score	1.0	1.3	2.3	1.5	-1.2	-1.2	-0.3
Pavlov. Cond. latency score	1.0	1.3	2.3	1.5	-1.2	-1.2	-0.2
Pavlov. Cond. lever contacts	0.3	0.4	0.6	0.8	-0.5	-0.6	-0.4
Pavlov. Cond. magazine entry number	1.6	2.0	3.2	-1.8	1.5	1.5	-0.1
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.7	-0.9	0.6	0.7	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	1.8	1.4	-1.1	-1.1	-0.2
Pavlov. Cond. response bias	0.3	0.4	0.7	0.8	-0.6	-0.6	-0.3
Pavlov. Cond. lever latency	8.1	10.9	18.1	-4.2	3.6	3.6	-0.2
Pavlov. Cond. magazine entry latency	3.2	3.7	5.2	2.3	-2.1	-2.1	0.8
Pavlov. Cond. change in total contacts	7.4	10.1	16.1	4.0	-3.5	-3.5	0.6
Pavlov. Cond. index score	7.0	9.0	14.4	3.8	-3.2	-3.3	0.4
Pavlov. Cond. latency score	6.5	8.1	12.9	3.6	-3.1	-3.1	0.5
Pavlov. Cond. lever contacts	8.5	11.6	19.1	4.4	-3.7	-3.7	0.3
Pavlov. Cond. magazine entry number	5.5	6.7	9.7	-3.1	2.8	2.8	-1.1
Pavlov. Cond. intertrial magazine entries	1.1	1.5	2.6	-0.9	1.1	1.1	-1.6
Pavlov. Cond. lever-magazine prob. diff.	6.2	7.8	12.8	3.6	-3.0	-3.1	0.3
Pavlov. Cond. response bias	9.3	12.6	20.5	4.5	-3.9	-3.9	0.5
Time in closed arm before self-admin	6.1	6.9	7.4	2.6	-2.7	-2.7	2.6
Time in closed arm after self-admin	0.2	0.2	0.9	-0.2	-0.1	-0.0	0.9
Time in open arm before self-admin	4.9	5.3	6.6	-2.6	2.5	2.5	-1.3
Time in open arm after self-admin	0.7	0.8	1.9	-0.5	0.7	0.7	-1.4
Bone: periosteal estimation	0.2	0.4	1.5	0.5	0.0	-0.2	-1.2
Bone: periosteal perimeter	0.2	0.4	0.7	0.7	-0.3	-0.4	-0.9
Bone: post-yield work	0.1	0.1	0.2	0.4	-0.4	-0.4	0.1
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	-0.2	0.1	0.1	0.0
Progressive ratio test 1 breakpoint	0.1	0.1	0.1	-0.3	0.2	0.2	-0.2
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.3	0.5	-0.6	-0.6	-0.2
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	0.7	-0.5	-0.5	-0.3
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	0.7	-0.5	-0.5	-0.4
Progressive ratio test 2 inactive lever presses	1.1	1.3	1.6	1.2	-1.3	-1.3	0.6
Incentive Sensitization - Responses	0.4	0.4	0.9	1.0	-0.6	-0.6	-0.4
Incentive Sensitization - Breakpoint	0.5	0.5	1.0	1.0	-0.7	-0.7	-0.2
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.0	-0.1	-0.1	0.5
Progressive ratio	0.3	0.3	0.4	0.4	-0.6	-0.5	0.6
Food seeking constrained by brief footshock	0.2	0.3	1.0	0.2	0.2	0.1	-1.0
Seeking ratio, punishment vs. effort	0.6	0.8	2.2	-0.3	0.7	0.5	-1.5
Retroperitoneal fat weight	8.3	27.3	29.2	-5.1	5.3	5.4	-5.1
Reaction time number correct	1.2	1.7	3.1	1.0	-1.1	-1.2	1.8
Reaction time mean minus median	0.1	0.2	0.3	0.5	-0.4	-0.3	-0.5
Reaction time mean minus median AUC	0.7	0.9	1.3	1.2	-1.1	-1.0	0.3
Reaction time num false alarms	2.2	3.0	3.8	-2.0	1.9	1.8	-1.1
Reaction time num false alarms AUC	0.9	1.2	1.7	-1.3	1.2	1.2	-0.6
Reaction time trials correct on left	1.2	1.7	3.1	1.0	-1.1	-1.2	1.8
Reaction time trials on left	1.2	1.7	3.1	1.0	-1.1	-1.2	1.8
Reaction time mean	1.1	1.5	1.7	-1.3	1.3	1.3	-1.0
Reaction time mean AUC	1.0	1.3	1.8	-1.3	1.2	1.2	-0.7
Median of all reaction times	1.3	1.8	2.4	-1.5	1.4	1.4	-0.8
Reaction time omissions	0.5	0.7	0.7	-0.9	0.9	0.8	-0.7
Reaction time false alarm rate	2.0	2.9	3.3	-1.8	1.8	1.8	-1.4
Reaction time premature initiation rate	0.8	1.1	3.8	-0.1	0.4	0.6	-1.9
Reaction time premature initiations	0.2	0.3	0.4	0.6	-0.4	-0.3	-0.7
Std. dev. reaction times	0.6	0.9	2.1	-0.5	0.8	0.8	-1.4
Reaction time trials completed	1.2	1.7	3.1	1.0	-1.1	-1.2	1.8
Reaction time trials AUC	0.9	1.2	2.3	0.9	-0.9	-1.0	1.5
Run reversals in cocaine runway, females	5.9	5.7	8.3	-2.0	2.3	2.2	-2.9
Run reversals in cocaine runway, males	0.0	0.0	0.0	-0.1	-0.0	-0.0	0.2
Latency to leave start box in cocaine runway	3.7	4.0	4.9	-2.2	2.2	2.1	-1.4
Latency to leave start box in cocaine runway, F	4.6	5.1	5.7	-2.3	2.4	2.3	-2.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	-0.2	-0.0	-0.0	0.6
Std. dev. time between licks in bursts	1.0	1.2	3.9	-0.3	0.7	0.6	-2.0
Total sessions with >9 infusions	2.9	3.2	4.0	2.0	-2.0	-2.0	0.9
Short access day 1 total inactive lever presses	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.2
Short access day 10 total inactive lever presses	0.0	0.0	0.1	-0.1	0.1	0.1	0.3
Short access day 1 total infusions	1.2	1.3	2.1	1.4	-1.3	-1.3	0.0
Short access day 10 total infusions	0.4	0.4	0.7	0.8	-0.7	-0.7	-0.4
Short access total infusions	0.5	0.6	0.8	0.9	-0.9	-0.9	-0.2
Short access day 1 locomotion	3.3	3.6	4.2	1.9	-2.1	-2.1	1.4
Short access day 10 total locomotion	0.0	0.0	0.1	0.3	-0.1	-0.1	-0.2
Short access total locomotion	0.1	0.2	0.2	0.4	-0.4	-0.4	0.2
One hour access (0.3 mA shock)	1.0	1.2	2.0	1.4	-1.2	-1.2	0.2
Compulsive drug intake	0.4	0.4	0.9	0.4	-0.5	-0.5	0.9
One hour access (shock baseline)	0.5	0.6	1.1	1.0	-0.8	-0.8	-0.2
Social response proportion	0.9	0.9	1.1	-0.9	1.0	1.0	-0.9
Social responses	1.7	2.2	2.8	-1.3	1.4	1.5	-1.7
Social time	0.8	1.0	1.8	-1.4	1.0	1.0	0.4
Soleus weight	1.6	4.7	7.4	-1.7	2.1	2.1	-2.7
Bone: stiffness	0.6	1.0	1.1	-1.0	1.0	1.0	-1.0
Tibialis anterior weight	0.1	0.4	1.2	-0.3	0.5	0.5	-1.1
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	0.1	-0.2	-0.2	0.4
Time to tail flick, vehicle, after self-admin	3.3	3.6	4.7	2.0	-2.2	-2.1	1.1
Time to tail flick, test, before self-admin	0.1	0.1	0.4	0.1	0.0	0.1	-0.6
Time to tail flick, test, after self-admin	0.7	0.7	1.9	-0.4	0.6	0.6	-1.4
Delta time to tail flick, vehicle, before/after SA	1.9	1.9	2.7	1.5	-1.6	-1.6	0.6
Delta time to tail flick, test, before/after SA	0.3	0.3	0.4	-0.6	0.6	0.6	-0.4
Tibia length	2.4	6.8	8.1	2.8	-2.7	-2.8	2.0
Ambulatory time before self-admin	0.7	0.8	1.2	-1.1	0.9	1.0	-0.1
Ambulatory time after self-admin	1.6	1.8	3.7	0.9	-1.2	-1.2	1.9
Bone: tissue strength	1.1	1.1	2.5	0.6	-0.9	-0.8	1.6
Total heroin consumption	0.6	0.7	0.8	0.9	-0.9	-0.9	0.7
Bone: trabecular number	0.2	0.3	0.8	-0.4	0.3	0.2	0.9
Bone: trabecular spacing	0.6	0.8	1.1	1.0	-1.1	-1.0	0.3
Bone: trabecular thickness	0.3	0.4	0.6	-0.6	0.8	0.6	-0.4
Bone: trabecular tissue density	3.6	5.0	5.5	-2.2	2.3	2.3	-2.1
Water consumed over 24 hours	0.1	0.2	0.3	-0.5	0.4	0.4	0.3
Number of responses in last shaping day	0.1	0.1	0.4	0.0	0.1	0.1	-0.7