Hub : Genes

Jup

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	mRNA stability	Jup	0.1	0.06	7.3e-03	-0.01	0.04	0	-0.01	4.8e-01	5.2e-02	3.1e-01	4.9e-01
2	Adipose	gene expression	Jup	0.04	0.02	2.6e-06	0.02	0.04	0.03	0.03	5.8e-03	2.0e-05	4.1e-04	4.9e-04
3	Brain	gene expression	Jup	0.07	0.04	8.5e-07	0.06	0.06	0.06	0.06	2.7e-06	1.9e-06	1.3e-06	2.0e-06
4	Liver	gene expression	Jup	0.04	0.03	9.0e-04	0.02	0	0.01	0.01	2.8e-03	1.1e-01	1.5e-02	1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.5	0.9	1.0	-1.0	1.0	0.8	-0.9
Area under the delay curve	0.3	0.3	0.5	0.3	-0.7	-0.5	0.6
BMI with tail	0.4	1.1	1.4	1.2	-0.9	-1.0	1.1
BMI without tail	2.4	4.9	6.8	1.7	-1.9	-2.5	2.6
Body weight	0.2	0.7	2.0	1.4	-0.8	0.2	0.1
Weight adjusted by age	1.8	2.0	3.3	1.3	-1.5	-0.9	1.8
Bone surface	0.4	0.7	1.6	-0.0	0.4	1.0	-1.2
Bone volume	0.6	1.0	2.1	-0.2	0.8	1.1	-1.4
Breakpoint value in progressive ratio session	1.0	1.1	4.0	-0.4	-0.1	-0.5	2.0
Number of licking bursts	0.5	0.5	1.0	-1.0	1.0	0.3	-0.3
Context. condit. distance diff. score	2.1	2.5	4.4	1.3	-1.9	-2.1	0.6
Locomotion velocity, session 1	0.1	0.1	0.2	0.1	0.1	0.4	-0.5
Locomotion distance, session 1	0.6	0.7	1.3	1.1	-1.0	-0.7	0.3
Locomotion velocity, session 2	0.1	0.1	0.3	-0.2	0.2	-0.2	-0.5
Locomotion distance, session 2	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1
Locomotion velocity, session 3	0.6	0.7	1.4	0.5	-0.9	-1.2	0.6
Locomotion distance, session 3	0.8	0.8	1.2	0.9	-1.1	-0.9	0.7
Stereotopy head waving bouts, day 3	1.6	1.9	2.4	-1.5	1.3	1.3	-1.3
Stereotopy head waving duration, day 3	0.5	0.6	1.2	-0.5	0.6	0.8	-1.1
Locomotion velocity, session 7	0.1	0.2	0.3	0.6	-0.1	-0.2	-0.4
Locomotion distance, session 7	1.2	1.5	2.9	1.7	-1.4	-1.1	0.0
Stereotopy head waving bouts, day 7	1.3	1.4	2.6	-1.6	1.4	0.7	-0.9
Stereotopy head waving duration, day 7	1.8	2.2	3.9	-2.0	1.7	1.2	-0.9
Locomotion velocity, session 8	1.1	1.3	2.0	1.4	-1.4	-1.1	0.6
Locomotion distance, session 8	0.7	1.0	1.9	0.9	-1.1	-1.4	-0.1
Degree of sensitization distance	0.4	0.4	0.8	0.9	-0.5	-0.1	-0.8
Degree of sensitization stereotypy	0.9	1.0	2.1	-1.4	1.2	0.4	-0.6
Conditioned locomotion	0.1	0.1	0.4	-0.6	0.3	-0.2	-0.1
Cocaine response after cond. corrected	0.2	0.2	0.4	-0.6	0.4	-0.1	0.6
Cocaine response after cond. not corrected	0.2	0.3	0.5	-0.7	0.6	0.2	0.5
Cocaine response before conditioning	0.1	0.2	0.6	-0.1	0.2	0.7	-0.3
Saline control response	0.2	0.2	0.5	0.3	-0.4	0.5	0.7
Bone: connectivity density	0.8	1.2	1.4	-1.2	1.1	1.1	-1.0
Bone: cortical apparent density	3.0	3.9	5.3	-2.2	2.3	2.0	-1.3
Bone: cortical area	1.1	1.7	2.8	-0.7	1.0	1.6	-1.7
Bone: cortical porosity	0.5	0.6	0.8	0.8	-0.8	-0.9	0.5
Bone: cortical porosity	0.5	0.5	0.7	0.7	-0.8	-0.8	0.5
Bone: cortical thickness	1.6	2.6	3.2	-1.8	1.7	1.5	-1.6
Bone: cortical thickness	1.9	2.2	4.3	-2.1	1.5	0.9	-1.3
Bone: cortical tissue density	2.9	3.8	5.2	-2.2	2.3	1.9	-1.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.5	0.1	0.0	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.5	-0.7	0.1	0.1	-0.2
Condit. Reinf. active responses	0.1	0.1	0.3	-0.5	0.2	-0.0	-0.2
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.1	0.2	0.2	-0.1
Incentive salience index mean	0.1	0.1	0.5	-0.7	0.2	-0.1	0.0
Condit. Reinf. lever presses	0.2	0.3	0.9	-0.1	-0.2	-0.3	0.9
Condit. Reinf. active minus inactive responses	0.4	0.5	0.8	-0.8	0.9	0.3	-0.7
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.0	0.0	-0.1	0.2
Condit. Reinf. active responses	0.8	1.1	1.7	-1.1	1.3	0.7	-1.1
Condit. Reinf. inactive responses	1.0	1.2	1.8	-1.2	1.3	0.9	-1.0
Condit. Reinf. lever presses	0.1	0.2	0.6	0.1	-0.3	-0.8	0.2
Condit. Reinf. lever reinforcers received	0.7	1.0	1.3	-1.1	1.2	0.5	-1.0
Conditioned reinforcement - actives	0.4	0.4	0.6	0.5	-0.6	-0.7	0.8
Conditioned reinforcement - inactives	1.6	1.8	4.7	-0.8	1.2	2.2	-0.7
Conditioned locomotion	2.5	3.0	4.1	1.5	-1.6	-1.8	2.0
Patch foraging indifference point 0 sec	0.0	0.1	0.1	-0.3	0.2	-0.1	-0.3
Patch foraging indifference point AUC	0.4	0.4	0.7	-0.7	0.7	0.8	-0.2
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	0.0	-0.1	0.1	0.1
Delay disc. indifference point, 16s delay	0.4	0.4	0.6	-0.4	-0.5	-0.7	0.8
Delay disc. indifference point, 2s delay	0.1	0.1	0.4	-0.2	0.3	0.7	-0.2
Delay disc. indifference point, 24s delay	0.5	0.5	0.8	0.7	-0.9	-0.8	0.3
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	-0.3	-0.0	0.5	-0.4
Delay disc. indifference point, 8s delay	0.5	0.5	0.7	0.8	-0.8	-0.6	0.7
Indifference point function ln k	0.2	0.3	0.8	-0.2	0.3	0.4	-0.9
Indifference point function log k	0.2	0.3	0.8	-0.2	0.3	0.4	-0.9
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	-0.2	0.2	-0.1	-0.2
Patch foraging total patch changes 12 sec	1.5	2.0	2.8	-1.7	1.5	1.4	-0.9
Patch foraging total patch changes 18 sec	0.1	0.1	0.1	-0.3	0.2	-0.2	0.3
Patch foraging total patch changes 24 sec	0.2	0.2	0.5	-0.7	0.4	0.1	-0.3
Patch foraging total patch changes 6 sec	0.1	0.1	0.2	-0.1	-0.1	-0.4	0.3
Patch foraging time to switch 0 sec	0.6	0.9	2.4	0.6	-0.9	-1.6	0.2
Patch foraging water rate 0 sec	0.1	0.1	0.4	0.2	-0.0	-0.2	0.6
Patch foraging water rate 12 sec	0.2	0.3	0.5	-0.4	0.6	0.7	-0.3
Patch foraging water rate 18 sec	2.1	2.9	3.7	-1.5	1.6	1.8	-1.9
Patch foraging water rate 24 sec	0.2	0.2	0.5	0.2	-0.3	-0.6	0.7
Patch foraging water rate 6 sec	1.0	1.4	2.3	-1.5	1.4	0.9	-0.8
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.6	0.1	-0.4	-0.8	-0.3
Distance traveled before self-admin	1.4	1.5	2.2	1.5	-1.5	-1.1	0.7
Distance traveled after self-admin	0.6	0.7	1.2	0.9	-0.8	-1.1	0.3
Extensor digitorum longus weight	5.0	19.7	29.0	5.4	-4.9	-4.0	3.1
Bone: elastic displacement	2.6	2.9	3.3	1.7	-1.6	-1.8	1.7
Bone: elastic work	0.7	0.9	1.3	0.9	-1.0	-1.1	0.7
Bone: endosteal estimation	1.1	2.4	6.3	2.5	-1.7	-0.5	-0.3
Bone: endosteal perimeter	0.4	0.8	2.3	1.5	-0.8	0.2	-0.4
Epididymis fat weight	0.4	0.9	3.0	0.5	-0.6	0.1	1.7
Delta time in closed arm before/after self-admin	0.3	0.3	0.9	0.0	0.1	0.5	-1.0
Delta time in open arm before/after self-admin	0.2	0.2	0.4	-0.1	0.2	0.6	0.6
Diff in mean of infusions in LGA sessions	2.0	2.2	2.9	1.1	-1.4	-1.7	1.6
Delay discount exponential model param	0.3	0.3	0.5	-0.3	0.7	0.5	-0.6
Extinction: sum of active levers before priming	2.7	2.6	3.4	1.8	-1.7	-1.3	1.7
Active lever presses in extinction session 6	0.3	0.3	1.1	-0.3	-0.1	0.2	1.1
Bone: final force	2.3	3.7	6.5	-1.3	1.7	2.0	-2.5
Bone: final moment	2.0	3.2	5.9	-1.1	1.5	1.9	-2.4
Food consumed during 24 hour testing period	0.0	0.0	0.0	-0.0	0.0	0.0	0.1
Glucose	0.1	0.2	0.3	0.4	-0.3	-0.5	0.5
Heart weight	0.8	1.1	1.6	1.3	-1.2	-0.5	1.0
Delay discount hyperbolic model param	0.2	0.2	0.5	-0.3	0.7	0.3	-0.5
Intermittent access intake day 1-15 change	1.7	1.7	2.8	-1.4	1.7	1.2	-0.8
Intermittent access intake escalation	2.4	2.3	3.6	-1.8	1.9	1.3	-0.9
Intermittent access intake escalation 2	1.0	1.0	1.9	-1.2	1.4	0.5	-0.6
Intermitt. access day 1 inactive lever presses	1.4	1.4	2.7	-1.5	0.9	1.7	0.4
Intermitt. access day 15 inactive lever presses	2.8	3.1	5.4	-1.9	1.8	2.3	-0.2
Intermitt. access escalation Index	0.8	0.7	2.8	0.1	-0.1	0.1	-1.7
Intermittent access day 1 total infusions	0.2	0.3	0.7	0.4	-0.4	0.9	-0.0
Intermittent access day 15 total infusions	1.4	1.6	3.0	-1.1	1.0	1.7	-1.1
Intermittent access terminal intake (last 3 days)	1.5	1.6	2.9	-1.0	1.0	1.7	-1.2
Intermittent access total infusions	0.6	0.7	1.8	-0.4	0.4	1.3	-0.8
Intermittent access day 1 locomotion	0.4	0.4	0.9	0.5	-0.2	0.9	0.5
Intermittent access day 15 total locomotion	0.6	0.7	1.3	-0.2	0.9	1.1	-0.8
Intermittent access total locomotion	0.3	0.3	0.8	-0.3	0.5	0.9	0.2
Intermittent access standard deviation	0.7	0.7	1.2	-1.1	1.0	0.5	0.7
Left kidney weight	0.5	1.3	2.0	-1.4	0.9	0.9	-1.3
Right kidney weight	0.7	2.1	2.5	-1.6	1.2	1.6	-1.4
Cocaine induced anxiety	0.9	1.0	2.0	0.5	-1.0	-0.9	1.4
Post-drug Anxiety	1.5	1.6	4.7	0.4	-1.0	-0.8	2.2
Baseline Anxiety	0.2	0.2	0.6	0.4	-0.3	-0.1	0.8
Tail length	1.0	3.2	5.0	1.4	-1.8	-1.6	2.2
Length with tail	0.1	0.4	0.8	0.9	-0.7	0.4	0.0
Length without tail	1.2	2.6	5.4	-0.5	1.0	2.3	-1.9
Times rat made contact with spout	0.2	0.3	0.7	0.4	-0.2	-0.4	0.8
Lifetime Intake	0.8	0.9	2.7	-0.4	0.4	1.6	-0.9
Liver weight, left	0.0	0.0	0.1	0.2	-0.2	-0.3	-0.1
Liver weight, right	1.0	1.7	3.5	-1.9	1.3	1.1	-0.5
Locomotor activity	0.5	0.9	1.3	-1.1	1.1	0.6	-0.8
Locomotor testing distance	0.5	0.9	1.3	-1.2	1.1	0.6	-0.8
Locomotor testing rearing	0.2	0.3	0.8	-0.9	0.4	-0.3	-0.6
Locomotion in novel chamber	0.7	0.9	1.6	-1.0	0.6	0.8	-1.3
Locomotion in novel chamber post-restriction	0.1	0.1	0.3	0.1	0.3	0.6	-0.1
Fecal boli incidents, locomotor time 1	0.1	0.1	0.1	0.2	0.4	-0.3	0.2
Change in fecal boli incidents, locomotor task	0.4	0.4	1.0	-1.0	0.5	0.7	-0.0
Time >=10cm from walls, locomotor time 1	1.2	1.2	1.4	-1.2	1.2	1.1	-1.0
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.4	-0.4	-0.2	0.3
Total resting periods, locomotor time 1	0.4	0.4	0.8	0.9	-0.7	-0.4	0.5
Rest time, locomotor task time 1	0.2	0.2	0.5	0.7	-0.3	-0.3	0.3
Distance moved, locomotor task time 1	0.2	0.2	0.3	-0.6	0.1	0.6	-0.2
Vertical activity count, locomotor time 1	0.1	0.1	0.3	0.4	-0.5	-0.0	0.4
Time >=10cm from walls, locomotor time 2	2.9	3.1	3.7	-1.9	1.9	1.7	-1.6
Bouts of movement, locomotor time 2	1.1	1.2	2.1	0.5	-1.1	-1.1	1.5
Total resting periods, locomotor time 2	1.3	1.4	2.1	0.7	-1.3	-1.1	1.4
Rest time, locomotor task time 2	1.0	1.2	2.1	1.0	-0.9	-0.8	1.5
Distance moved, locomotor task time 2	0.4	0.5	1.1	-0.2	0.1	0.8	-1.0
Vertical activity count, locomotor time 2	0.5	0.5	0.8	0.9	-0.9	-0.7	0.1
Light reinforcement 1	0.4	0.8	1.6	-1.3	0.9	0.8	-0.0
Light reinforcement 2	0.0	0.0	0.2	-0.4	0.1	-0.0	0.0
Bone: marrow area	1.0	2.2	5.9	2.4	-1.7	-0.4	-0.3
Bone: maximum diameter	0.9	1.6	2.8	-0.5	0.9	1.7	-1.6
Bone: maximum force	0.5	0.9	2.4	0.1	0.4	1.0	-1.6
Bone: maximum moment	0.4	0.7	2.1	0.4	0.1	0.8	-1.4
Mean time between licks in bursts	0.4	0.6	2.0	0.5	-0.2	-0.4	1.4
Mean num. licks in bursts	1.2	1.4	2.1	1.4	-1.4	-0.7	1.1
Cd content in liver	2.2	2.4	3.6	1.3	-1.6	-1.9	1.3
Co content in liver	0.3	0.3	0.9	0.2	-0.1	-0.5	-1.0
Cu content in liver	0.4	0.4	1.0	-0.0	-0.3	-0.8	1.0
Fe content in liver	0.1	0.1	0.2	-0.1	-0.2	-0.4	0.4
K content in liver	5.7	5.6	8.3	-2.9	2.7	1.8	-2.0
Mg content in liver	6.1	6.3	9.0	-3.0	2.7	2.2	-2.0
Mn content in liver	12.4	14.0	18.8	-4.3	4.1	3.6	-2.7
Na content in liver	0.3	0.3	0.6	-0.4	0.8	0.6	0.3
Rb content in liver	2.4	3.0	3.6	-1.9	1.8	1.3	-1.8
Se content in liver	2.5	3.1	6.2	-2.5	1.9	1.5	-0.6
Sr content in liver	0.7	0.6	1.6	-0.6	0.6	0.5	-1.2
Zn content in liver	0.1	0.2	0.4	-0.4	0.1	-0.6	0.3
Bone: minimum diameter	0.2	0.4	0.8	0.9	-0.5	0.3	-0.8
Time in familiar zone, hab. session 1	1.1	1.0	1.4	-1.2	1.1	1.1	-0.5
Time in novel zone, hab. session 1	0.1	0.1	0.1	0.4	-0.2	-0.0	-0.3
Total zone transitions, hab. session 1	1.8	2.6	3.7	1.7	-1.9	-1.8	0.7
Total locomotion distance, hab. session 1	0.1	0.2	0.3	0.3	-0.6	-0.5	-0.5
Locomotion velocity, hab. session 1	0.3	0.4	0.8	0.6	-0.9	-0.8	-0.1
Time in familiar zone, hab. session 2	1.0	1.0	2.3	-1.5	1.0	0.4	0.7
Time in novel zone, hab. session 2	0.9	0.9	3.0	0.5	0.0	0.4	-1.7
Total zone transitions, hab. session 2	0.8	1.0	1.7	1.3	-1.2	-1.0	-0.2
Total locomotion distance, hab. session 2	0.2	0.3	0.4	0.7	-0.4	-0.5	-0.6
Locomotion velocity, hab. session 2	0.5	0.6	0.9	0.9	-0.8	-1.0	-0.3
Novel to familiar place preference ratio	0.3	0.3	0.5	0.5	-0.7	-0.3	0.6
Novelty place preference	0.1	0.1	0.2	0.3	-0.5	-0.1	0.3
Time in novel zone, NPP test	0.0	0.0	0.1	-0.2	-0.0	0.3	-0.2
Total zone transitions, NPP test	1.6	2.2	3.5	1.9	-1.7	-1.4	0.7
Total locomotion distance, NPP test	0.3	0.4	0.7	0.8	-0.7	-0.3	-0.6
Locomotion velocity, NPP test	1.1	1.5	2.5	1.6	-1.5	-1.1	0.4
Intraocular pressure	5.1	7.2	8.4	2.6	-2.7	-2.5	2.9
Delta distance traveled before/after self-admin	0.6	0.6	1.0	-1.0	1.0	0.2	-0.7
Delta ambulatory time before/after self-admin	0.3	0.3	0.6	-0.7	0.8	0.1	-0.5
Parametrial fat weight	0.1	0.1	0.1	-0.3	0.2	0.4	0.4
Pavlov. Cond. lever latency	0.9	1.1	1.5	1.2	-1.1	-1.1	0.8
Pavlov. Cond. magazine entry latency	2.9	3.7	5.6	-2.4	2.2	1.1	-1.8
Pavlov. Cond. change in total contacts	1.8	1.9	4.5	-2.1	1.5	0.9	-0.6
Pavlov. Cond. index score	1.5	1.8	2.9	-1.7	1.6	1.0	-1.0
Pavlov. Cond. latency score	1.6	2.0	2.6	-1.6	1.6	1.2	-1.2
Pavlov. Cond. lever contacts	0.3	0.3	0.5	-0.7	0.6	0.6	-0.3
Pavlov. Cond. magazine entry number	3.3	4.1	6.3	2.5	-2.3	-1.4	1.6
Pavlov. Cond. intertrial magazine entries	1.1	1.3	1.5	1.2	-1.2	-1.0	1.2
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	3.3	-1.8	1.6	1.0	-0.9
Pavlov. Cond. response bias	1.3	1.6	3.3	-1.8	1.4	0.7	-0.8
Pavlov. Cond. lever latency	0.2	0.2	0.6	0.3	-0.5	0.0	0.8
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.2	-0.0	-0.1	-0.4
Pavlov. Cond. change in total contacts	0.7	1.0	2.5	-0.7	1.0	0.3	-1.6
Pavlov. Cond. index score	0.2	0.3	0.8	-0.2	0.4	-0.1	-0.9
Pavlov. Cond. latency score	0.1	0.2	0.5	-0.0	0.3	-0.1	-0.7
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.3	0.4	-0.3	-0.4
Pavlov. Cond. magazine entry number	0.8	1.0	3.0	0.5	-0.8	-0.4	1.7
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.4	-0.1	-0.2	0.2	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.2	-0.2	0.4	-0.0	-1.1
Pavlov. Cond. response bias	0.4	0.6	1.2	-0.7	0.7	0.1	-1.1
Time in closed arm before self-admin	0.3	0.4	1.0	-1.0	0.6	-0.2	0.4
Time in closed arm after self-admin	0.2	0.2	0.4	-0.7	0.1	-0.5	0.5
Time in open arm before self-admin	0.1	0.2	0.3	0.4	-0.3	-0.1	-0.6
Time in open arm after self-admin	0.2	0.2	0.6	0.4	-0.0	0.8	-0.3
Bone: periosteal estimation	0.4	0.7	1.6	0.9	-0.2	0.8	-1.3
Bone: periosteal perimeter	0.2	0.4	0.9	0.6	-0.1	0.6	-0.9
Bone: post-yield work	0.4	0.6	1.2	0.9	-0.6	0.2	-1.1
Progressive ratio test 1 active lever presses	0.4	0.4	1.4	-0.3	0.3	1.2	-0.4
Progressive ratio test 1 breakpoint	0.4	0.5	1.5	-0.4	0.3	1.2	-0.2
Progressive ratio test 1 inactive lever presses	1.5	1.7	3.8	-1.2	1.0	1.9	-0.7
Progressive ratio test 2 active lever presses	0.7	0.7	1.8	-0.5	0.7	1.3	-0.6
Progressive ratio test 2 breakpoint	0.5	0.6	1.7	-0.3	0.6	1.3	-0.5
Progressive ratio test 2 inactive lever presses	1.2	1.4	3.7	-0.7	0.9	1.9	-0.8
Incentive Sensitization - Responses	0.1	0.2	0.3	0.3	0.3	0.5	-0.4
Incentive Sensitization - Breakpoint	0.2	0.2	0.3	0.2	0.4	0.6	-0.5
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.8	-0.9	0.6	0.3	-0.4
Progressive ratio	0.1	0.1	0.2	0.3	-0.2	-0.3	0.4
Food seeking constrained by brief footshock	0.1	0.2	0.2	-0.5	0.4	0.5	-0.3
Seeking ratio, punishment vs. effort	0.1	0.1	0.1	-0.4	0.3	0.4	-0.4
Retroperitoneal fat weight	0.0	0.0	0.2	-0.1	-0.1	-0.0	0.4
Reaction time number correct	0.1	0.1	0.3	0.6	-0.3	0.1	0.1
Reaction time mean minus median	0.1	0.2	0.6	0.7	-0.3	0.1	-0.0
Reaction time mean minus median AUC	0.1	0.2	0.3	0.3	0.1	0.5	-0.6
Reaction time num false alarms	0.3	0.4	0.8	-0.8	0.9	0.3	0.1
Reaction time num false alarms AUC	0.3	0.4	1.0	-0.7	1.0	0.2	-0.1
Reaction time trials correct on left	0.1	0.1	0.3	0.6	-0.3	0.1	0.1
Reaction time trials on left	0.1	0.1	0.3	0.5	-0.2	0.1	0.1
Reaction time mean	1.6	2.3	2.7	-1.6	1.6	1.3	-1.6
Reaction time mean AUC	1.0	1.4	1.7	-1.3	1.2	1.0	-1.3
Median of all reaction times	2.9	3.9	5.0	-2.2	2.1	1.6	-2.0
Reaction time omissions	1.2	1.7	2.6	-1.6	1.6	0.8	-0.9
Reaction time false alarm rate	0.3	0.4	0.8	-0.8	0.9	0.1	0.0
Reaction time premature initiation rate	0.2	0.2	0.5	-0.7	0.0	0.2	0.5
Reaction time premature initiations	0.1	0.1	0.4	-0.2	-0.2	0.2	0.6
Std. dev. reaction times	0.2	0.2	0.4	-0.3	0.6	0.5	-0.4
Reaction time trials completed	0.1	0.1	0.3	0.5	-0.2	0.1	0.1
Reaction time trials AUC	0.0	0.1	0.2	0.5	-0.2	0.2	0.0
Run reversals in cocaine runway, females	0.3	0.3	0.8	0.3	-0.9	-0.0	0.6
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.2	-0.2	0.2	-0.5
Latency to leave start box in cocaine runway	0.8	0.8	1.9	0.5	-0.7	-0.8	1.4
Latency to leave start box in cocaine runway, F	2.4	2.6	5.3	1.1	-1.5	-1.3	2.3
Latency to leave start box in cocaine runway, M	0.4	0.4	0.6	-0.8	0.7	0.2	-0.7
Std. dev. time between licks in bursts	0.3	0.4	1.3	0.2	-0.2	-0.4	1.1
Total sessions with >9 infusions	0.3	0.3	0.7	0.2	-0.6	-0.1	0.8
Short access day 1 total inactive lever presses	1.8	2.0	5.2	-0.6	0.8	2.3	-1.4
Short access day 10 total inactive lever presses	0.2	0.3	0.5	0.4	-0.6	0.1	0.7
Short access day 1 total infusions	1.9	2.0	4.5	-1.0	0.8	2.1	-1.5
Short access day 10 total infusions	0.3	0.4	1.0	0.5	-0.4	1.0	0.3
Short access total infusions	1.0	1.1	3.1	-0.6	0.4	1.8	-0.8
Short access day 1 locomotion	0.2	0.2	0.4	-0.6	0.2	0.6	0.2
Short access day 10 total locomotion	0.4	0.4	0.9	0.0	0.3	0.9	0.8
Short access total locomotion	0.2	0.2	0.6	0.1	-0.0	0.8	0.4
One hour access (0.3 mA shock)	0.2	0.3	0.8	0.1	0.0	0.9	-0.6
Compulsive drug intake	0.4	0.4	0.7	0.8	-0.7	-0.3	0.3
One hour access (shock baseline)	0.1	0.1	0.3	-0.1	0.1	0.5	-0.5
Social response proportion	2.0	2.1	3.2	0.8	-1.4	-1.8	1.7
Social responses	0.3	0.4	0.8	-0.1	-0.2	-0.7	0.9
Social time	0.4	0.5	1.0	1.0	-0.6	0.3	0.8
Soleus weight	0.2	0.5	0.8	0.9	-0.5	-0.8	0.6
Bone: stiffness	1.1	1.7	2.9	-0.8	0.9	1.6	-1.7
Tibialis anterior weight	0.9	3.1	4.5	2.1	-2.0	-1.5	1.3
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.5	-0.1	0.0	-0.6
Time to tail flick, vehicle, after self-admin	3.7	4.0	4.3	2.1	-2.1	-1.8	2.0
Time to tail flick, test, before self-admin	0.5	0.5	0.8	0.9	-0.7	-0.7	0.2
Time to tail flick, test, after self-admin	0.7	0.7	1.0	-0.7	0.9	1.0	-0.6
Delta time to tail flick, vehicle, before/after SA	1.4	1.3	2.8	1.1	-1.0	-0.6	1.7
Delta time to tail flick, test, before/after SA	0.7	0.6	0.7	-0.8	0.8	0.8	-0.6
Tibia length	0.1	0.2	0.3	0.4	0.0	0.6	-0.5
Ambulatory time before self-admin	2.4	2.5	3.5	1.9	-1.8	-1.6	0.8
Ambulatory time after self-admin	1.1	1.2	1.8	1.3	-1.1	-1.2	0.4
Bone: tissue strength	0.2	0.2	0.4	0.6	-0.5	-0.1	0.4
Total heroin consumption	0.3	0.4	0.8	-0.9	0.8	0.3	0.3
Bone: trabecular number	1.4	2.2	2.8	-1.7	1.7	1.4	-1.2
Bone: trabecular spacing	1.4	1.8	2.6	1.4	-1.3	-1.1	1.6
Bone: trabecular thickness	0.7	0.8	1.8	-0.5	0.9	0.8	-1.3
Bone: trabecular tissue density	0.2	0.2	0.7	-0.4	0.3	-0.1	-0.8
Water consumed over 24 hours	1.0	1.2	1.7	-1.1	1.1	1.3	-0.7
Number of responses in last shaping day	0.4	0.5	1.5	-0.4	0.1	0.4	1.2