Hub : Genes

Jund

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Jund	0.02	0.01	9.9e-03	0.01	0.01	0	0	1.3e-02	5.5e-02	3.4e-01	8.5e-02
2	RMTg	gene expression	Jund	0.23	0.11	3.4e-06	0.21	0.2	0.25	0.22	2.3e-06	6.1e-06	2.4e-07	2.1e-06
3	Brain	gene expression	Jund	0.14	0.06	0.0e+00	0.2	0.2	0.2	0.2	1.9e-18	2.6e-18	2.0e-18	1.5e-18
4	Adipose	gene expression	Jund	0.03	0.02	3.6e-03	0	0.01	0.01	0.01	7.8e-02	8.4e-03	1.6e-02	2.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.1	1.9	6.4	-2.5	0.7	0.9	0.3
Area under the delay curve	0.1	0.1	0.2	0.3	-0.5	-0.1	0.2
BMI with tail	1.3	4.5	6.4	-2.5	2.3	2.0	1.4
BMI without tail	2.6	7.9	9.9	-3.1	2.8	2.8	2.5
Body weight	4.7	20.7	30.0	-5.5	4.6	4.5	3.3
Weight adjusted by age	1.6	2.5	2.8	-1.7	1.6	1.6	1.4
Bone surface	0.7	1.2	4.1	-2.0	0.6	0.4	-0.2
Bone volume	1.4	2.6	7.4	-2.7	1.1	1.1	0.5
Breakpoint value in progressive ratio session	0.1	0.1	0.2	-0.2	-0.2	-0.1	-0.5
Number of licking bursts	0.1	0.2	0.5	0.7	-0.3	-0.3	-0.2
Context. condit. distance diff. score	0.3	0.4	1.2	1.1	0.5	0.1	0.0
Locomotion velocity, session 1	0.9	0.9	2.1	0.9	-0.4	-0.8	-1.5
Locomotion distance, session 1	2.3	2.9	4.9	1.3	-1.5	-1.7	-2.2
Locomotion velocity, session 2	0.4	0.5	1.0	-0.3	0.6	1.0	0.7
Locomotion distance, session 2	2.8	3.9	5.7	1.3	-2.1	-2.0	-2.4
Locomotion velocity, session 3	1.2	1.4	3.9	2.0	-0.7	-0.8	-0.7
Locomotion distance, session 3	0.5	0.6	1.1	0.3	-0.6	-0.8	-1.1
Stereotopy head waving bouts, day 3	1.2	1.4	4.0	2.0	-0.6	-0.7	-0.8
Stereotopy head waving duration, day 3	0.6	0.7	2.6	1.6	-0.2	-0.1	-0.2
Locomotion velocity, session 7	1.0	1.1	1.5	1.2	-1.0	-1.0	-1.0
Locomotion distance, session 7	1.0	1.2	1.6	0.8	-1.2	-1.3	-1.0
Stereotopy head waving bouts, day 7	0.0	0.1	0.1	0.2	0.1	0.2	-0.3
Stereotopy head waving duration, day 7	0.2	0.3	0.5	0.3	0.6	0.7	0.3
Locomotion velocity, session 8	3.2	3.8	8.8	3.0	-1.1	-1.5	-1.7
Locomotion distance, session 8	1.0	1.5	2.6	1.2	-0.8	-1.2	-1.6
Degree of sensitization distance	0.2	0.2	0.5	0.7	-0.5	-0.4	0.0
Degree of sensitization stereotypy	0.2	0.3	0.4	-0.6	0.6	0.5	-0.0
Conditioned locomotion	0.0	0.0	0.1	-0.2	0.3	0.0	0.0
Cocaine response after cond. corrected	0.4	0.5	1.3	0.1	0.7	0.5	1.2
Cocaine response after cond. not corrected	0.2	0.3	0.8	0.9	-0.0	-0.1	0.5
Cocaine response before conditioning	1.9	2.2	2.7	1.4	-1.6	-1.3	-1.6
Saline control response	0.3	0.4	0.8	0.3	-0.6	-0.5	-0.9
Bone: connectivity density	1.0	1.6	5.4	-2.3	0.7	0.6	0.1
Bone: cortical apparent density	0.3	0.4	0.9	-0.4	-1.0	-0.4	-0.4
Bone: cortical area	6.5	10.0	15.9	-4.0	2.9	3.2	2.3
Bone: cortical porosity	0.2	0.3	0.7	-0.1	-0.2	-0.5	-0.8
Bone: cortical porosity	0.2	0.2	0.7	-0.1	-0.1	-0.5	-0.9
Bone: cortical thickness	4.1	6.7	11.5	-3.4	2.4	2.6	1.6
Bone: cortical thickness	2.4	2.9	4.2	-1.9	2.0	1.6	1.0
Bone: cortical tissue density	0.3	0.4	1.1	-0.2	-1.1	-0.5	-0.5
Condit. Reinf. active minus inactive responses	0.3	0.3	0.5	-0.7	0.5	0.7	-0.0
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.4	-1.2	0.4	0.8	0.3
Condit. Reinf. active responses	0.3	0.4	0.6	-0.7	0.8	0.7	0.0
Condit. Reinf. inactive responses	0.2	0.2	0.5	-0.3	0.7	0.4	0.2
Incentive salience index mean	0.3	0.4	0.8	-0.9	0.5	0.7	-0.3
Condit. Reinf. lever presses	0.3	0.4	0.7	-0.8	0.3	0.5	-0.7
Condit. Reinf. active minus inactive responses	0.3	0.3	0.6	0.4	-0.6	-0.5	-0.8
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.5	-0.5	0.5	0.7	0.4
Condit. Reinf. active responses	1.5	2.0	2.2	1.5	-1.4	-1.4	-1.4
Condit. Reinf. inactive responses	2.9	3.8	5.6	2.4	-1.8	-2.0	-1.5
Condit. Reinf. lever presses	0.0	0.1	0.2	0.4	-0.0	0.1	0.2
Condit. Reinf. lever reinforcers received	0.4	0.6	0.8	0.9	-0.8	-0.7	-0.6
Conditioned reinforcement - actives	1.5	2.5	3.0	-1.5	1.7	1.5	1.6
Conditioned reinforcement - inactives	7.9	11.6	13.0	-3.1	3.6	3.5	3.4
Conditioned locomotion	1.8	2.4	3.2	-1.1	1.6	1.6	1.8
Patch foraging indifference point 0 sec	2.0	3.7	5.9	-1.1	2.4	2.1	1.7
Patch foraging indifference point AUC	0.1	0.1	0.3	0.2	-0.5	-0.3	0.0
Delay disc. indifference point, 0s delay	3.0	3.2	4.8	2.2	-1.9	-1.7	-1.4
Delay disc. indifference point, 16s delay	0.6	0.7	1.1	1.0	-0.9	-0.9	-0.0
Delay disc. indifference point, 2s delay	0.8	0.8	1.3	0.8	-1.2	-0.7	-1.0
Delay disc. indifference point, 24s delay	0.2	0.2	0.5	0.4	0.3	0.3	0.7
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	0.2	-0.5	-0.1	-0.4
Delay disc. indifference point, 8s delay	0.3	0.3	0.9	-0.1	0.2	0.6	1.0
Indifference point function ln k	0.8	1.4	2.2	-1.3	1.5	1.0	0.8
Indifference point function log k	0.8	1.4	2.2	-1.3	1.5	1.0	0.8
Patch foraging total patch changes 0 sec	3.1	5.9	8.8	-1.6	3.0	2.7	2.3
Patch foraging total patch changes 12 sec	0.5	0.7	1.0	0.2	1.0	0.8	1.0
Patch foraging total patch changes 18 sec	0.1	0.1	0.4	0.6	0.1	-0.2	0.0
Patch foraging total patch changes 24 sec	0.3	0.4	1.0	-0.1	1.0	0.7	0.5
Patch foraging total patch changes 6 sec	1.0	1.5	2.4	-0.0	1.6	1.4	1.2
Patch foraging time to switch 0 sec	1.4	2.9	3.9	1.5	-2.0	-1.7	-1.5
Patch foraging water rate 0 sec	0.9	2.0	2.5	-1.4	1.5	1.6	1.1
Patch foraging water rate 12 sec	0.6	1.2	2.3	-1.5	1.2	0.9	0.6
Patch foraging water rate 18 sec	0.2	0.3	0.6	-0.8	-0.0	-0.4	-0.7
Patch foraging water rate 24 sec	0.5	0.8	2.5	-1.6	0.6	0.5	-0.2
Patch foraging water rate 6 sec	1.8	2.6	3.8	-1.6	2.0	1.4	1.4
Seeking ratio, delayed vs. immediate footshock	1.3	1.6	2.4	1.5	-1.3	-1.2	-1.0
Distance traveled before self-admin	0.4	0.5	0.7	-0.4	0.8	0.8	0.7
Distance traveled after self-admin	0.7	0.9	1.3	-0.9	1.1	1.0	0.6
Extensor digitorum longus weight	0.2	0.6	1.2	-0.2	1.1	0.9	0.6
Bone: elastic displacement	0.5	0.6	1.0	0.3	-0.9	-0.6	-1.0
Bone: elastic work	1.4	1.9	2.6	-1.6	1.2	1.6	1.1
Bone: endosteal estimation	0.2	0.4	0.7	-0.6	0.6	0.5	0.9
Bone: endosteal perimeter	1.3	2.7	3.3	-1.5	1.8	1.7	1.6
Epididymis fat weight	0.9	3.1	8.2	-2.9	0.9	1.6	0.9
Delta time in closed arm before/after self-admin	0.1	0.1	0.4	-0.2	0.1	0.3	0.6
Delta time in open arm before/after self-admin	0.8	0.8	1.2	0.3	-1.1	-1.0	-0.9
Diff in mean of infusions in LGA sessions	0.6	0.7	1.0	-0.2	0.9	1.0	1.0
Delay discount exponential model param	0.0	0.0	0.1	-0.0	0.1	-0.2	-0.4
Extinction: sum of active levers before priming	0.9	1.0	1.8	-0.1	-1.2	-1.0	-1.3
Active lever presses in extinction session 6	0.3	0.3	0.4	0.6	-0.6	-0.5	-0.4
Bone: final force	7.9	12.7	15.7	-4.0	3.6	3.6	3.1
Bone: final moment	7.8	12.5	15.1	-3.9	3.6	3.5	3.1
Food consumed during 24 hour testing period	0.6	0.9	1.8	0.0	-0.9	-0.9	-1.3
Glucose	1.0	1.6	2.2	-1.3	1.1	1.5	1.2
Heart weight	1.1	1.8	3.3	-1.0	1.8	1.5	0.7
Delay discount hyperbolic model param	0.0	0.0	0.0	-0.1	0.2	-0.2	-0.2
Intermittent access intake day 1-15 change	0.2	0.5	1.4	-1.2	0.4	0.5	0.2
Intermittent access intake escalation	0.1	0.3	1.0	-1.0	0.1	0.2	-0.1
Intermittent access intake escalation 2	0.6	0.7	1.9	-1.4	0.4	0.6	0.5
Intermitt. access day 1 inactive lever presses	0.1	0.3	0.5	-0.3	0.7	0.7	0.6
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.1	0.3	0.4	-0.1	0.1
Intermitt. access escalation Index	0.4	0.5	0.7	0.9	-0.7	-0.8	-0.6
Intermittent access day 1 total infusions	1.0	1.6	2.5	-0.3	1.5	1.2	1.6
Intermittent access day 15 total infusions	0.5	0.8	1.2	-1.1	0.9	0.7	0.7
Intermittent access terminal intake (last 3 days)	0.6	0.8	1.3	-1.1	0.8	0.7	0.8
Intermittent access total infusions	1.9	2.2	2.7	-1.4	1.5	1.5	1.6
Intermittent access day 1 locomotion	2.3	2.9	3.7	-1.3	1.9	1.7	1.8
Intermittent access day 15 total locomotion	0.3	0.6	1.2	-1.1	0.6	0.5	0.6
Intermittent access total locomotion	2.5	3.0	3.1	-1.7	1.7	1.8	1.8
Intermittent access standard deviation	0.2	0.4	0.5	-0.6	0.6	0.6	0.7
Left kidney weight	0.2	1.2	1.7	-1.1	1.1	1.3	0.7
Right kidney weight	0.9	4.1	6.8	-2.6	1.7	2.1	1.4
Cocaine induced anxiety	0.9	1.3	2.0	-0.1	1.4	1.3	1.3
Post-drug Anxiety	0.1	0.1	0.3	0.6	0.0	0.1	0.1
Baseline Anxiety	2.7	3.1	4.6	1.1	-2.2	-1.9	-1.8
Tail length	0.7	2.7	3.9	-2.0	1.3	1.8	1.4
Length with tail	1.9	8.2	13.3	-3.6	2.5	3.0	2.0
Length without tail	1.9	6.0	10.3	-3.2	2.4	2.4	1.4
Times rat made contact with spout	0.3	0.3	0.5	-0.2	-0.7	-0.6	-0.6
Lifetime Intake	3.0	3.6	4.5	-1.6	2.1	1.9	2.0
Liver weight, left	0.7	1.2	2.0	-0.3	-1.4	-0.9	-1.4
Liver weight, right	1.4	2.5	5.8	-2.4	0.9	1.5	1.0
Locomotor activity	0.6	0.9	1.4	-1.2	-0.9	-0.1	-1.1
Locomotor testing distance	0.4	0.8	1.5	-0.4	-1.1	-0.6	-1.2
Locomotor testing rearing	0.5	1.1	2.2	0.1	-1.1	-1.0	-1.5
Locomotion in novel chamber	0.2	0.3	1.0	-1.0	-0.1	0.3	-0.1
Locomotion in novel chamber post-restriction	0.5	0.9	2.7	-1.7	-0.2	-0.1	-0.8
Fecal boli incidents, locomotor time 1	0.1	0.2	0.5	-0.3	-0.7	-0.2	-0.1
Change in fecal boli incidents, locomotor task	0.6	0.6	1.8	1.3	-0.3	-0.6	-0.3
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.3	-0.0	-0.2	0.2
Bouts of movement, locomotor time 1	0.6	0.6	1.1	-0.2	-0.9	-1.0	-0.7
Total resting periods, locomotor time 1	1.0	1.2	2.0	0.2	-1.2	-1.4	-1.0
Rest time, locomotor task time 1	0.2	0.3	0.8	0.9	-0.3	-0.4	0.1
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.2	0.2	-0.1	-0.0
Vertical activity count, locomotor time 1	0.0	0.1	0.2	-0.5	-0.3	-0.0	-0.4
Time >=10cm from walls, locomotor time 2	0.4	0.6	0.8	0.7	-0.9	-0.8	-0.6
Bouts of movement, locomotor time 2	0.2	0.3	0.4	0.6	-0.5	-0.5	-0.6
Total resting periods, locomotor time 2	0.1	0.2	0.3	0.5	-0.3	-0.4	-0.4
Rest time, locomotor task time 2	0.2	0.2	0.5	-0.3	0.4	0.5	0.7
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.3	-0.0	-0.1	-0.0
Vertical activity count, locomotor time 2	0.0	0.0	0.1	0.0	-0.2	0.2	-0.1
Light reinforcement 1	0.0	0.1	0.2	0.0	-0.0	0.2	0.5
Light reinforcement 2	0.4	0.7	2.0	0.3	0.4	0.7	1.4
Bone: marrow area	0.1	0.3	0.6	-0.6	0.5	0.4	0.7
Bone: maximum diameter	3.0	5.5	6.4	-2.3	2.5	2.5	2.0
Bone: maximum force	6.6	11.8	17.4	-4.2	3.3	3.4	2.6
Bone: maximum moment	6.1	10.7	15.6	-3.9	3.2	3.3	2.5
Mean time between licks in bursts	1.3	3.2	4.2	-1.8	1.5	2.0	1.7
Mean num. licks in bursts	0.2	0.3	1.2	-1.1	0.0	0.1	-0.1
Cd content in liver	2.9	3.2	5.8	-2.4	1.4	1.6	1.6
Co content in liver	0.0	0.0	0.0	0.2	-0.0	0.0	-0.0
Cu content in liver	1.8	2.1	3.9	1.0	-1.2	-1.4	-2.0
Fe content in liver	0.9	1.0	2.5	0.7	-1.6	-0.9	-0.7
K content in liver	2.5	2.4	4.8	2.2	-1.3	-1.3	-1.1
Mg content in liver	0.2	0.2	0.6	0.8	0.1	-0.3	-0.2
Mn content in liver	0.1	0.1	0.2	0.3	0.4	0.2	-0.1
Na content in liver	3.7	3.9	4.8	1.7	-2.2	-1.9	-2.1
Rb content in liver	2.5	2.9	3.9	-0.7	2.0	1.8	2.0
Se content in liver	0.4	0.4	0.7	0.7	-0.4	-0.5	-0.8
Sr content in liver	0.4	0.3	0.6	-0.2	-0.8	-0.7	-0.3
Zn content in liver	0.1	0.1	0.2	0.2	-0.5	-0.4	-0.4
Bone: minimum diameter	2.3	4.1	8.0	-2.8	1.5	1.9	1.6
Time in familiar zone, hab. session 1	0.2	0.1	0.4	-0.7	0.0	0.3	0.3
Time in novel zone, hab. session 1	0.0	0.0	0.0	0.1	0.2	0.1	0.0
Total zone transitions, hab. session 1	0.6	0.9	1.5	0.3	-1.0	-1.0	-1.2
Total locomotion distance, hab. session 1	1.8	2.5	4.0	0.5	-1.9	-1.5	-2.0
Locomotion velocity, hab. session 1	1.8	2.5	3.9	0.7	-1.8	-1.5	-2.0
Time in familiar zone, hab. session 2	0.1	0.1	0.1	-0.1	0.3	0.2	0.3
Time in novel zone, hab. session 2	0.1	0.1	0.2	-0.4	-0.2	0.2	0.2
Total zone transitions, hab. session 2	0.1	0.1	0.3	0.2	0.0	-0.4	-0.5
Total locomotion distance, hab. session 2	0.4	0.5	1.4	-0.0	-0.3	-0.6	-1.2
Locomotion velocity, hab. session 2	0.5	0.7	1.9	0.2	-0.5	-0.8	-1.4
Novel to familiar place preference ratio	0.5	0.5	1.2	-1.1	-0.0	0.6	0.8
Novelty place preference	0.3	0.3	0.6	-0.8	-0.1	0.5	0.7
Time in novel zone, NPP test	0.2	0.2	0.5	-0.7	-0.4	0.2	0.4
Total zone transitions, NPP test	0.9	1.2	2.4	0.6	-0.8	-1.2	-1.5
Total locomotion distance, NPP test	1.9	2.6	5.0	0.9	-1.4	-1.6	-2.2
Locomotion velocity, NPP test	1.8	2.6	4.5	1.1	-1.4	-1.6	-2.1
Intraocular pressure	1.5	2.1	3.0	-0.9	1.3	1.7	1.7
Delta distance traveled before/after self-admin	0.5	0.6	1.3	-1.1	0.6	0.7	0.5
Delta ambulatory time before/after self-admin	0.1	0.2	0.4	-0.6	0.4	0.4	0.2
Parametrial fat weight	3.5	8.2	10.6	-2.4	2.8	2.9	3.3
Pavlov. Cond. lever latency	0.3	0.4	1.1	0.1	0.5	0.2	1.1
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	-0.6	0.3	0.3	0.3
Pavlov. Cond. change in total contacts	0.4	0.4	0.7	-0.7	0.6	0.9	0.3
Pavlov. Cond. index score	0.2	0.2	0.6	-0.1	-0.5	-0.4	-0.8
Pavlov. Cond. latency score	0.4	0.5	1.1	0.3	-0.7	-0.5	-1.0
Pavlov. Cond. lever contacts	0.2	0.2	0.6	-0.2	-0.4	-0.1	-0.8
Pavlov. Cond. magazine entry number	0.1	0.2	0.4	0.6	-0.4	-0.3	-0.3
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.4	-0.0	0.1	-0.0	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	-0.0	-0.4	-0.3	-0.6
Pavlov. Cond. response bias	0.1	0.1	0.4	-0.6	0.1	0.2	-0.1
Pavlov. Cond. lever latency	0.3	0.4	0.9	0.2	-0.3	-0.9	-0.8
Pavlov. Cond. magazine entry latency	0.3	0.3	0.5	-0.3	0.4	0.7	0.7
Pavlov. Cond. change in total contacts	0.3	0.4	0.8	0.2	0.5	0.9	0.8
Pavlov. Cond. index score	0.6	0.7	1.4	-0.2	0.7	1.2	1.1
Pavlov. Cond. latency score	0.2	0.3	0.7	0.1	0.3	0.8	0.7
Pavlov. Cond. lever contacts	0.2	0.3	0.7	0.1	0.3	0.8	0.7
Pavlov. Cond. magazine entry number	0.9	1.2	1.7	0.8	-0.9	-1.3	-1.3
Pavlov. Cond. intertrial magazine entries	0.5	0.7	1.3	0.3	-0.6	-1.1	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.5	-0.3	0.7	1.2	1.1
Pavlov. Cond. response bias	0.5	0.7	1.1	-0.4	0.6	1.1	1.0
Time in closed arm before self-admin	4.1	5.2	8.2	-0.7	2.9	2.6	2.4
Time in closed arm after self-admin	4.9	5.2	7.8	-0.9	2.5	2.4	2.8
Time in open arm before self-admin	1.4	1.5	2.9	0.3	-1.2	-1.2	-1.7
Time in open arm after self-admin	3.2	3.5	6.6	0.4	-1.9	-1.8	-2.6
Bone: periosteal estimation	2.2	4.7	7.2	-2.7	2.0	2.1	1.8
Bone: periosteal perimeter	5.2	8.9	10.0	-3.0	3.2	3.1	2.6
Bone: post-yield work	0.1	0.1	0.4	-0.6	-0.0	-0.1	-0.3
Progressive ratio test 1 active lever presses	2.4	3.0	4.8	-1.1	2.2	1.9	1.6
Progressive ratio test 1 breakpoint	2.2	2.7	4.3	-1.0	2.1	1.8	1.5
Progressive ratio test 1 inactive lever presses	1.2	1.7	2.8	-0.9	1.7	1.4	1.2
Progressive ratio test 2 active lever presses	1.2	1.4	1.8	-0.9	1.3	1.2	1.3
Progressive ratio test 2 breakpoint	0.9	1.0	1.3	-0.8	1.1	1.0	1.1
Progressive ratio test 2 inactive lever presses	1.2	1.9	3.1	-1.0	1.8	1.4	1.3
Incentive Sensitization - Responses	0.1	0.2	0.6	-0.3	0.3	0.2	0.8
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	-0.2	0.0	-0.0	0.6
Sum of active levers in priming session hrs 5-6	3.3	3.1	4.4	0.5	-2.1	-1.9	-2.0
Progressive ratio	0.0	0.0	0.0	-0.1	-0.0	-0.0	0.2
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.4	-0.5	-0.2	-0.3
Seeking ratio, punishment vs. effort	0.3	0.4	0.7	-0.1	-0.7	-0.5	-0.9
Retroperitoneal fat weight	2.9	12.2	13.3	-3.6	3.4	3.6	3.3
Reaction time number correct	0.4	0.8	2.0	-0.4	-0.6	-0.8	-1.4
Reaction time mean minus median	0.0	0.1	0.3	0.5	-0.2	-0.1	-0.2
Reaction time mean minus median AUC	0.1	0.2	0.4	0.6	0.4	0.2	-0.0
Reaction time num false alarms	0.8	1.1	1.8	-0.3	1.2	1.3	1.0
Reaction time num false alarms AUC	0.5	0.8	1.5	-0.1	0.9	1.2	0.9
Reaction time trials correct on left	0.4	0.8	2.0	-0.4	-0.6	-0.8	-1.4
Reaction time trials on left	0.4	0.7	1.8	-0.5	-0.6	-0.7	-1.3
Reaction time mean	0.9	1.5	2.8	-0.5	1.1	1.3	1.7
Reaction time mean AUC	0.4	0.6	1.4	0.1	0.6	0.7	1.2
Median of all reaction times	1.3	1.9	3.8	-0.6	1.2	1.4	2.0
Reaction time omissions	0.8	1.1	1.6	-0.9	1.0	1.3	1.1
Reaction time false alarm rate	1.2	1.6	2.5	-0.3	1.2	1.6	1.5
Reaction time premature initiation rate	0.4	0.5	1.4	0.3	-0.4	-0.7	-1.2
Reaction time premature initiations	0.5	0.9	2.4	-0.0	-0.5	-0.9	-1.6
Std. dev. reaction times	0.2	0.4	0.7	-0.6	0.6	0.8	0.7
Reaction time trials completed	0.4	0.7	1.8	-0.5	-0.6	-0.7	-1.3
Reaction time trials AUC	0.3	0.6	1.3	-0.7	-0.4	-0.6	-1.1
Run reversals in cocaine runway, females	3.8	3.8	5.2	-1.8	2.3	1.9	1.9
Run reversals in cocaine runway, males	1.5	1.5	1.9	1.1	-1.0	-1.3	-1.4
Latency to leave start box in cocaine runway	0.0	0.0	0.1	-0.3	-0.0	-0.3	0.0
Latency to leave start box in cocaine runway, F	0.3	0.3	0.8	-0.9	0.5	0.2	0.3
Latency to leave start box in cocaine runway, M	0.4	0.4	0.7	0.9	-0.6	-0.7	-0.1
Std. dev. time between licks in bursts	2.0	2.7	3.9	-2.0	1.4	1.7	1.5
Total sessions with >9 infusions	4.9	6.0	9.1	-2.0	3.0	2.4	2.3
Short access day 1 total inactive lever presses	2.1	2.8	3.8	-1.2	1.9	1.5	1.9
Short access day 10 total inactive lever presses	0.5	1.1	3.7	1.9	-0.3	-0.7	-0.4
Short access day 1 total infusions	4.1	5.5	6.9	-2.4	2.6	2.3	2.1
Short access day 10 total infusions	1.1	1.4	2.4	-1.0	1.6	1.1	1.1
Short access total infusions	2.8	3.5	5.5	-1.4	2.3	1.8	1.8
Short access day 1 locomotion	6.8	8.4	10.3	-2.3	3.2	3.1	3.0
Short access day 10 total locomotion	1.3	2.3	4.3	-2.1	1.6	1.4	0.7
Short access total locomotion	3.5	4.2	5.2	-2.1	2.3	2.1	1.7
One hour access (0.3 mA shock)	0.8	0.9	1.4	-0.6	0.7	1.2	1.2
Compulsive drug intake	0.7	0.9	1.1	1.1	-1.0	-1.0	-0.6
One hour access (shock baseline)	2.3	3.5	4.4	-1.5	1.8	2.1	2.0
Social response proportion	2.9	3.2	5.1	-2.3	1.6	1.9	1.3
Social responses	0.3	0.4	1.4	-1.2	-0.1	0.5	-0.3
Social time	0.0	0.1	0.2	0.2	-0.0	0.5	0.0
Soleus weight	1.1	3.2	4.4	-1.3	1.8	1.9	2.1
Bone: stiffness	4.9	8.0	9.3	-3.0	3.0	2.9	2.3
Tibialis anterior weight	0.1	0.4	1.3	-1.1	-0.0	0.1	-0.5
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	-0.7	0.6	0.3	0.6
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	0.1	0.2	0.2	0.3
Time to tail flick, test, before self-admin	2.0	2.1	3.1	-0.7	1.5	1.8	1.6
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.4	-0.4	-0.5	0.0
Delta time to tail flick, vehicle, before/after SA	0.5	0.4	0.8	0.9	-0.6	-0.6	-0.6
Delta time to tail flick, test, before/after SA	0.8	0.9	1.5	0.0	-1.1	-1.2	-0.9
Tibia length	0.5	1.4	2.2	-1.2	1.5	1.2	0.8
Ambulatory time before self-admin	0.4	0.7	1.0	-0.4	0.9	1.0	0.9
Ambulatory time after self-admin	1.2	1.4	1.8	-1.3	1.2	1.3	0.8
Bone: tissue strength	0.0	0.0	0.1	-0.3	0.0	0.2	0.2
Total heroin consumption	0.1	0.1	0.2	-0.3	0.0	0.4	0.3
Bone: trabecular number	1.3	2.2	6.9	-2.6	0.8	1.0	0.4
Bone: trabecular spacing	0.2	0.3	0.8	0.9	-0.5	-0.2	0.0
Bone: trabecular thickness	1.0	1.3	4.0	-2.0	0.7	0.7	0.1
Bone: trabecular tissue density	0.5	0.7	1.2	0.3	-0.9	-0.9	-1.1
Water consumed over 24 hours	0.2	0.3	1.0	-1.0	-0.0	-0.2	-0.6
Number of responses in last shaping day	0.4	0.5	1.2	-1.1	0.6	0.5	0.2