Hub : Genes

Jsrp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Jsrp1	0.18	0.09	0.0e+00	0.28	0.29	0.28	0.29	2.6e-31	2.3e-32	7.2e-31	3.5e-32
2	NAcc	gene expression	Jsrp1	0.12	0.07	0.0e+00	0.17	0.16	0.15	0.16	4.4e-19	1.2e-17	9.4e-17	2.8e-18
3	OFC	gene expression	Jsrp1	0.36	0.18	3.7e-07	0.26	0.23	0.25	0.26	6.6e-07	3.3e-06	1.0e-06	8.4e-07
4	Brain	gene expression	Jsrp1	0.07	0.05	7.1e-06	0.04	0.04	0.03	0.03	1.2e-04	3.2e-04	5.1e-04	1.0e-03
5	IL	gene expression	Jsrp1	0.19	0.12	4.1e-04	0.11	0.09	0.1	0.09	1.4e-03	3.2e-03	2.2e-03	3.1e-03
6	BLA	gene expression	Jsrp1	0.24	0.13	1.9e-11	0.18	0.2	0.18	0.19	3.4e-10	8.7e-11	6.2e-10	1.3e-10
7	pVTA	gene expression	Jsrp1	0.09	0.07	3.2e-04	0.02	0.04	0.01	0.02	4.7e-02	1.0e-02	1.3e-01	3.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	0.4	0.7	1.4	-0.5	0.6	0.6	0.6	0.8	-1.1	-1.2
Area under the delay curve	2.6	2.8	3.3	-1.7	1.8	1.6	1.6	1.6	-1.7	-1.7
BMI with tail	6.0	19.4	21.4	-4.6	4.6	4.4	4.5	4.5	-4.1	-4.1
BMI without tail	1.7	3.4	4.3	-2.1	2.0	2.0	2.0	1.9	-1.5	-1.4
Body weight	1.0	4.3	4.8	-2.2	2.1	2.1	2.2	2.1	-1.9	-1.9
Weight adjusted by age	0.1	0.1	0.2	-0.4	0.2	0.4	0.3	0.3	-0.0	0.0
Bone surface	0.2	0.4	1.3	-0.1	0.3	0.3	0.3	0.5	-1.0	-1.2
Bone volume	0.2	0.4	1.3	-0.1	0.3	0.4	0.3	0.5	-1.0	-1.1
Breakpoint value in progressive ratio session	6.5	7.1	7.4	2.7	-2.7	-2.7	-2.7	-2.6	2.7	2.7
Number of licking bursts	0.1	0.1	0.2	0.1	-0.2	-0.2	-0.2	-0.1	0.4	0.5
Context. condit. distance diff. score	0.2	0.3	0.3	-0.6	0.6	0.6	0.6	0.6	-0.4	-0.4
Locomotion velocity, session 1	0.2	0.2	0.3	0.5	-0.4	-0.5	-0.4	-0.5	0.2	0.1
Locomotion distance, session 1	0.1	0.1	0.4	-0.0	0.2	0.1	0.2	0.1	-0.6	-0.7
Locomotion velocity, session 2	1.8	2.1	2.9	1.7	-1.5	-1.7	-1.5	-1.6	1.0	0.9
Locomotion distance, session 2	0.5	0.7	1.2	1.1	-0.9	-0.9	-0.9	-1.0	0.4	0.3
Locomotion velocity, session 3	6.2	7.2	7.6	2.7	-2.7	-2.7	-2.7	-2.8	2.6	2.6
Locomotion distance, session 3	0.0	0.0	0.0	0.0	-0.0	-0.1	-0.0	0.0	0.1	0.1
Stereotopy head waving bouts, day 3	4.0	4.7	5.4	2.3	-2.2	-2.2	-2.2	-2.3	1.9	1.9
Stereotopy head waving duration, day 3	5.1	6.1	7.0	2.6	-2.5	-2.5	-2.5	-2.6	2.2	2.2
Locomotion velocity, session 7	0.6	0.7	0.8	0.8	-0.8	-0.9	-0.8	-0.8	0.8	0.8
Locomotion distance, session 7	0.0	0.0	0.0	-0.2	0.1	-0.0	0.1	0.1	0.2	0.2
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	-0.2	0.3	0.2	0.3	0.2	-0.5	-0.6
Stereotopy head waving duration, day 7	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.1	-0.1	-0.2	-0.3
Locomotion velocity, session 8	0.1	0.1	0.2	0.4	-0.3	-0.3	-0.3	-0.4	-0.2	-0.2
Locomotion distance, session 8	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.2	-0.2	-0.0	-0.0
Degree of sensitization distance	0.3	0.3	0.4	-0.6	0.6	0.6	0.6	0.6	-0.6	-0.6
Degree of sensitization stereotypy	2.5	2.8	3.1	-1.6	1.6	1.6	1.6	1.7	-1.7	-1.8
Conditioned locomotion	0.8	0.9	1.3	-1.1	1.0	1.1	1.1	0.9	-0.7	-0.6
Cocaine response after cond. corrected	3.3	3.7	4.8	-2.2	2.1	2.0	2.0	1.9	-1.5	-1.5
Cocaine response after cond. not corrected	3.4	3.8	5.0	-2.2	2.1	2.1	2.1	1.9	-1.6	-1.5
Cocaine response before conditioning	0.3	0.4	0.5	0.7	-0.7	-0.6	-0.6	-0.7	0.5	0.5
Saline control response	0.0	0.0	0.0	-0.2	0.1	0.2	0.2	0.1	-0.1	-0.1
Bone: connectivity density	0.7	1.1	1.8	-0.8	1.0	0.9	1.0	1.1	-1.3	-1.3
Bone: cortical apparent density	0.8	1.0	1.2	-1.0	1.0	1.1	1.0	1.1	-1.0	-0.9
Bone: cortical area	0.9	1.4	1.8	-1.1	1.1	1.2	1.1	1.2	-1.3	-1.3
Bone: cortical porosity	0.3	0.3	0.5	0.7	-0.6	-0.6	-0.6	-0.6	0.4	0.4
Bone: cortical porosity	0.1	0.1	0.2	-0.1	0.1	0.2	0.1	0.2	-0.4	-0.5
Bone: cortical thickness	1.4	2.3	2.5	-1.4	1.5	1.6	1.5	1.5	-1.5	-1.5
Bone: cortical thickness	0.1	0.1	0.2	0.2	-0.3	-0.2	-0.3	-0.3	0.5	0.5
Bone: cortical tissue density	0.5	0.7	0.8	-0.8	0.8	0.9	0.8	0.9	-0.8	-0.7
Condit. Reinf. active minus inactive responses	3.9	4.4	4.8	2.2	-2.1	-2.2	-2.1	-2.1	2.0	2.0
Condit. Reinf. active-inactive response ratio	2.6	2.8	3.0	1.6	-1.6	-1.7	-1.6	-1.6	1.7	1.7
Condit. Reinf. active responses	2.6	3.2	4.0	2.0	-1.9	-1.9	-1.9	-1.8	1.5	1.5
Condit. Reinf. inactive responses	0.3	0.3	0.6	0.8	-0.6	-0.6	-0.6	-0.6	0.3	0.2
Incentive salience index mean	1.5	1.8	2.3	1.5	-1.4	-1.5	-1.4	-1.4	1.1	1.1
Condit. Reinf. lever presses	0.2	0.2	0.7	-0.2	0.4	0.2	0.4	0.4	-0.7	-0.8
Condit. Reinf. active minus inactive responses	3.1	3.8	4.2	1.9	-1.9	-1.9	-1.9	-1.9	2.1	2.0
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.9	0.6	-0.6	-0.7	-0.7	-0.6	0.9	0.9
Condit. Reinf. active responses	2.5	3.4	3.5	1.8	-1.8	-1.9	-1.9	-1.8	1.9	1.8
Condit. Reinf. inactive responses	1.0	1.2	1.3	1.1	-1.1	-1.1	-1.1	-1.2	1.0	1.0
Condit. Reinf. lever presses	2.9	4.0	4.3	1.9	-2.0	-2.0	-2.0	-2.1	2.1	2.0
Condit. Reinf. lever reinforcers received	2.1	2.9	3.2	1.7	-1.7	-1.7	-1.7	-1.7	1.8	1.8
Conditioned reinforcement - actives	2.6	2.6	3.0	1.6	-1.7	-1.7	-1.7	-1.4	1.6	1.5
Conditioned reinforcement - inactives	0.3	0.3	0.4	-0.6	0.5	0.6	0.6	0.6	-0.4	-0.4
Conditioned locomotion	7.9	9.6	10.5	3.2	-3.1	-3.2	-3.2	-2.9	3.0	2.9
Patch foraging indifference point 0 sec	0.2	0.3	0.3	-0.5	0.5	0.6	0.5	0.5	-0.6	-0.6
Patch foraging indifference point AUC	1.1	1.3	1.4	1.1	-1.1	-1.2	-1.2	-1.0	1.2	1.1
Delay disc. indifference point, 0s delay	9.5	10.4	11.9	-3.1	3.1	3.1	3.2	3.2	-3.4	-3.4
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	-0.4	0.6	0.4	0.4	0.4	-0.4	-0.4
Delay disc. indifference point, 2s delay	6.8	7.5	7.8	-2.7	2.7	2.7	2.8	2.8	-2.8	-2.8
Delay disc. indifference point, 24s delay	0.5	0.5	0.9	-0.8	1.0	0.7	0.7	0.7	-0.6	-0.6
Delay disc. indifference point, 4s delay	1.7	1.7	2.0	-1.3	1.4	1.3	1.2	1.2	-1.4	-1.4
Delay disc. indifference point, 8s delay	0.9	1.0	1.2	-1.1	1.1	1.0	1.0	1.0	-0.8	-0.8
Indifference point function ln k	0.2	0.3	0.3	-0.6	0.5	0.6	0.6	0.5	-0.5	-0.5
Indifference point function log k	0.2	0.3	0.3	-0.6	0.5	0.6	0.6	0.5	-0.5	-0.5
Patch foraging total patch changes 0 sec	0.1	0.2	0.2	-0.4	0.4	0.5	0.4	0.4	-0.4	-0.4
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	-0.4	0.4	0.5	0.4	0.4	-0.2	-0.1
Patch foraging total patch changes 18 sec	1.2	1.5	1.6	1.3	-1.3	-1.2	-1.2	-1.2	1.2	1.2
Patch foraging total patch changes 24 sec	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.3	0.3	0.3
Patch foraging total patch changes 6 sec	0.2	0.3	0.3	0.6	-0.6	-0.5	-0.6	-0.5	0.5	0.4
Patch foraging time to switch 0 sec	2.3	3.5	4.4	-1.7	1.8	1.9	1.8	1.6	-2.1	-2.1
Patch foraging water rate 0 sec	0.3	0.5	0.9	0.4	-0.6	-0.6	-0.6	-0.3	0.9	0.9
Patch foraging water rate 12 sec	0.3	0.5	0.8	-0.9	0.7	0.7	0.8	0.7	-0.3	-0.3
Patch foraging water rate 18 sec	0.9	1.3	2.5	0.7	-1.0	-0.9	-1.0	-0.9	1.5	1.6
Patch foraging water rate 24 sec	0.1	0.2	0.6	-0.1	-0.1	-0.1	-0.1	0.0	0.7	0.8
Patch foraging water rate 6 sec	1.0	1.4	2.2	1.0	-1.1	-1.1	-1.1	-1.0	1.5	1.5
Seeking ratio, delayed vs. immediate footshock	4.0	4.6	5.4	2.3	-2.2	-2.3	-2.2	-2.1	2.0	1.9
Distance traveled before self-admin	0.5	0.5	0.7	-0.7	0.7	0.6	0.6	0.9	-0.7	-0.8
Distance traveled after self-admin	0.6	0.7	0.8	0.9	-0.8	-0.9	-0.9	-0.8	0.8	0.7
Extensor digitorum longus weight	3.8	14.9	17.2	-4.1	4.1	3.8	3.9	4.1	-3.4	-3.4
Bone: elastic displacement	0.2	0.2	0.4	0.5	-0.5	-0.6	-0.5	-0.5	0.4	0.4
Bone: elastic work	0.3	0.4	0.5	-0.6	0.6	0.6	0.6	0.6	-0.6	-0.7
Bone: endosteal estimation	0.3	0.7	0.8	-0.8	0.8	0.8	0.8	0.8	-0.9	-0.9
Bone: endosteal perimeter	0.1	0.2	0.2	0.5	-0.4	-0.4	-0.4	-0.5	0.2	0.2
Epididymis fat weight	0.3	0.6	0.8	0.7	-0.8	-0.7	-0.8	-0.8	0.8	0.9
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.4	0.3	0.3	0.3	0.4	0.2	0.3
Delta time in open arm before/after self-admin	1.5	1.5	1.6	-1.2	1.3	1.2	1.2	1.1	-1.3	-1.3
Diff in mean of infusions in LGA sessions	1.7	1.9	2.1	1.4	-1.4	-1.4	-1.4	-1.5	1.3	1.3
Delay discount exponential model param	2.3	2.4	2.9	1.6	-1.7	-1.5	-1.5	-1.5	1.5	1.5
Extinction: sum of active levers before priming	2.1	2.1	2.5	1.3	-1.5	-1.4	-1.4	-1.2	1.6	1.6
Active lever presses in extinction session 6	3.0	3.0	3.3	1.8	-1.8	-1.8	-1.8	-1.6	1.7	1.6
Bone: final force	1.7	2.7	3.1	-1.6	1.6	1.7	1.6	1.6	-1.7	-1.7
Bone: final moment	1.3	2.2	2.5	-1.4	1.4	1.5	1.4	1.4	-1.5	-1.6
Food consumed during 24 hour testing period	0.5	0.6	1.0	-0.8	0.7	0.7	0.7	1.0	-0.6	-0.6
Glucose	1.2	1.8	2.0	-1.4	1.4	1.3	1.4	1.4	-1.2	-1.2
Heart weight	0.5	0.8	1.0	0.8	-0.8	-0.8	-0.8	-0.8	1.0	1.0
Delay discount hyperbolic model param	3.3	3.5	3.9	1.9	-2.0	-1.8	-1.8	-1.9	1.8	1.8
Intermittent access intake day 1-15 change	7.8	7.7	8.0	2.8	-2.8	-2.8	-2.8	-2.7	2.8	2.7
Intermittent access intake escalation	8.7	8.5	9.3	2.8	-2.9	-2.9	-2.9	-2.7	3.1	3.0
Intermittent access intake escalation 2	10.4	10.2	11.1	3.1	-3.2	-3.2	-3.2	-3.1	3.3	3.3
Intermitt. access day 1 inactive lever presses	0.6	0.7	1.0	0.7	-0.7	-0.9	-0.9	-0.5	1.0	0.9
Intermitt. access day 15 inactive lever presses	0.6	0.7	0.8	0.8	-0.8	-0.8	-0.8	-0.9	0.9	0.9
Intermitt. access escalation Index	0.6	0.6	0.8	-0.6	0.7	0.7	0.7	0.8	-0.9	-0.9
Intermittent access day 1 total infusions	0.1	0.1	0.1	-0.3	0.2	0.3	0.3	0.2	-0.3	-0.3
Intermittent access day 15 total infusions	2.6	2.9	3.1	1.6	-1.8	-1.7	-1.7	-1.7	1.7	1.7
Intermittent access terminal intake (last 3 days)	1.4	1.5	1.7	1.2	-1.3	-1.2	-1.2	-1.2	1.2	1.2
Intermittent access total infusions	0.3	0.3	0.5	0.5	-0.7	-0.6	-0.6	-0.5	0.6	0.6
Intermittent access day 1 locomotion	0.4	0.4	0.5	0.6	-0.7	-0.6	-0.6	-0.7	0.6	0.7
Intermittent access day 15 total locomotion	4.1	4.4	4.6	2.1	-2.1	-2.2	-2.2	-2.0	2.1	2.0
Intermittent access total locomotion	1.1	1.2	1.4	1.1	-1.2	-1.2	-1.2	-1.0	1.1	1.0
Intermittent access standard deviation	3.9	4.1	4.4	2.0	-2.1	-2.1	-2.1	-1.9	2.1	2.0
Left kidney weight	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.0	-0.1	-0.1	-0.2
Right kidney weight	1.3	3.7	4.1	2.0	-2.0	-2.0	-2.0	-2.0	1.8	1.7
Cocaine induced anxiety	0.3	0.3	0.5	0.7	-0.6	-0.6	-0.6	-0.7	0.4	0.3
Post-drug Anxiety	0.1	0.1	0.4	0.4	-0.3	-0.3	-0.3	-0.7	-0.0	-0.0
Baseline Anxiety	0.2	0.2	0.4	0.3	-0.3	-0.3	-0.3	-0.6	0.4	0.5
Tail length	3.5	10.5	10.8	3.2	-3.2	-3.2	-3.2	-3.3	3.3	3.2
Length with tail	1.7	6.3	6.9	2.6	-2.6	-2.6	-2.6	-2.6	2.3	2.2
Length without tail	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.0	-0.0	-0.3	-0.3
Times rat made contact with spout	0.1	0.1	0.1	-0.3	0.3	0.3	0.3	0.3	-0.1	-0.0
Lifetime Intake	0.1	0.1	0.2	0.3	-0.5	-0.3	-0.3	-0.3	0.3	0.3
Liver weight, left	2.1	3.4	3.9	-2.0	1.9	1.9	1.9	1.8	-1.7	-1.6
Liver weight, right	1.9	3.1	3.2	-1.8	1.7	1.8	1.8	1.7	-1.7	-1.7
Locomotor activity	2.4	3.9	4.8	2.2	-2.1	-2.1	-2.1	-2.0	1.7	1.6
Locomotor testing distance	1.6	2.7	3.2	1.8	-1.8	-1.7	-1.7	-1.7	1.5	1.4
Locomotor testing rearing	0.1	0.1	0.2	0.3	-0.3	-0.3	-0.3	-0.4	0.4	0.5
Locomotion in novel chamber	0.5	0.6	0.9	0.8	-0.8	-0.8	-0.8	-0.6	0.9	0.9
Locomotion in novel chamber post-restriction	0.8	1.0	1.0	1.0	-1.0	-0.9	-1.0	-1.0	1.0	1.0
Fecal boli incidents, locomotor time 1	1.2	1.3	1.5	-1.2	1.1	1.2	1.2	1.2	-1.0	-1.0
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.3	-0.4	-0.3	-0.3	-0.3	0.2	0.1
Time >=10cm from walls, locomotor time 1	0.5	0.6	0.9	-0.7	0.7	0.7	0.7	0.7	-0.8	-0.9
Bouts of movement, locomotor time 1	0.2	0.2	0.3	0.5	-0.5	-0.5	-0.5	-0.5	0.5	0.5
Total resting periods, locomotor time 1	0.3	0.3	0.3	0.5	-0.5	-0.5	-0.5	-0.5	0.5	0.5
Rest time, locomotor task time 1	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.4	-0.3	0.3	0.3
Distance moved, locomotor task time 1	0.7	0.8	1.2	-0.8	0.9	0.8	0.8	0.8	-1.0	-1.1
Vertical activity count, locomotor time 1	0.0	0.0	0.1	-0.2	0.2	0.2	0.2	0.2	-0.0	-0.1
Time >=10cm from walls, locomotor time 2	0.8	0.8	1.0	-1.0	1.0	0.9	0.9	1.0	-0.7	-0.8
Bouts of movement, locomotor time 2	0.1	0.1	0.2	0.5	-0.4	-0.4	-0.4	-0.3	0.1	0.1
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.4	-0.3	-0.3	-0.3	-0.3	-0.0	0.0
Rest time, locomotor task time 2	0.3	0.4	0.5	0.7	-0.6	-0.6	-0.6	-0.7	0.4	0.4
Distance moved, locomotor task time 2	0.5	0.6	0.7	-0.8	0.8	0.8	0.8	0.8	-0.6	-0.6
Vertical activity count, locomotor time 2	0.3	0.3	0.5	-0.7	0.5	0.6	0.6	0.7	-0.3	-0.3
Light reinforcement 1	5.2	9.5	10.7	3.3	-3.1	-3.2	-3.1	-3.2	2.8	2.8
Light reinforcement 2	1.6	2.2	2.5	1.6	-1.5	-1.5	-1.5	-1.5	1.3	1.3
Bone: marrow area	0.3	0.7	0.8	-0.8	0.8	0.8	0.8	0.8	-0.9	-0.9
Bone: maximum diameter	0.3	0.5	0.8	0.9	-0.8	-0.7	-0.8	-0.8	0.5	0.4
Bone: maximum force	1.5	2.7	3.1	-1.6	1.6	1.8	1.6	1.5	-1.6	-1.7
Bone: maximum moment	1.3	2.2	2.6	-1.4	1.5	1.6	1.5	1.4	-1.5	-1.5
Mean time between licks in bursts	4.7	6.6	7.0	2.6	-2.6	-2.6	-2.6	-2.6	2.5	2.5
Mean num. licks in bursts	0.1	0.1	0.1	-0.3	0.3	0.3	0.3	0.3	-0.4	-0.4
Cd content in liver	0.2	0.3	0.3	-0.5	0.5	0.5	0.5	0.5	-0.5	-0.5
Co content in liver	0.7	0.8	0.9	0.9	-0.9	-0.9	-0.9	-0.9	0.9	0.9
Cu content in liver	0.3	0.4	0.6	-0.5	0.6	0.5	0.5	0.5	-0.7	-0.8
Fe content in liver	0.1	0.1	0.1	0.2	-0.3	-0.2	-0.2	-0.3	0.4	0.4
K content in liver	0.1	0.1	0.3	-0.2	0.3	0.2	0.3	0.3	-0.5	-0.6
Mg content in liver	0.2	0.2	0.4	-0.2	0.4	0.2	0.3	0.3	-0.6	-0.6
Mn content in liver	0.2	0.2	0.4	0.6	-0.5	-0.5	-0.4	-0.5	-0.0	-0.1
Na content in liver	1.5	1.6	2.0	-1.2	1.2	1.2	1.3	1.3	-1.4	-1.4
Rb content in liver	0.8	1.0	1.5	-0.8	0.9	0.9	0.9	1.0	-1.2	-1.2
Se content in liver	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.4	-0.3	0.3	0.3
Sr content in liver	0.1	0.1	0.3	0.2	-0.3	-0.3	-0.3	-0.2	0.5	0.5
Zn content in liver	3.2	3.6	4.6	1.7	-1.8	-1.9	-1.9	-1.7	2.1	2.2
Bone: minimum diameter	0.1	0.1	0.2	-0.2	0.3	0.4	0.3	0.3	-0.4	-0.5
Time in familiar zone, hab. session 1	2.7	2.5	3.1	1.5	-1.6	-1.5	-1.6	-1.8	1.6	1.6
Time in novel zone, hab. session 1	1.6	1.6	1.9	-1.1	1.2	1.2	1.2	1.3	-1.3	-1.4
Total zone transitions, hab. session 1	0.3	0.4	0.7	0.9	-0.7	-0.7	-0.7	-0.8	0.3	0.3
Total locomotion distance, hab. session 1	0.2	0.3	0.6	0.8	-0.6	-0.6	-0.6	-0.8	0.1	-0.0
Locomotion velocity, hab. session 1	0.6	0.8	1.2	1.1	-1.0	-1.0	-1.0	-1.1	0.4	0.4
Time in familiar zone, hab. session 2	7.6	7.8	8.1	2.7	-2.8	-2.8	-2.8	-2.8	2.8	2.8
Time in novel zone, hab. session 2	5.9	5.9	6.3	-2.4	2.4	2.4	2.4	2.4	-2.5	-2.5
Total zone transitions, hab. session 2	0.7	0.9	1.7	-0.7	0.8	0.9	0.8	0.7	-1.3	-1.3
Total locomotion distance, hab. session 2	0.3	0.4	0.7	0.8	-0.7	-0.7	-0.7	-0.9	0.3	0.2
Locomotion velocity, hab. session 2	0.2	0.3	0.6	0.7	-0.6	-0.6	-0.6	-0.7	0.1	0.1
Novel to familiar place preference ratio	5.5	5.6	6.4	-2.3	2.3	2.3	2.3	2.4	-2.5	-2.5
Novelty place preference	3.5	3.5	4.2	-1.8	1.9	1.8	1.9	1.9	-2.0	-2.0
Time in novel zone, NPP test	3.8	3.9	4.5	-1.9	2.0	1.9	2.0	2.0	-2.0	-2.1
Total zone transitions, NPP test	0.1	0.2	0.4	-0.2	0.3	0.3	0.3	0.2	-0.6	-0.6
Total locomotion distance, NPP test	0.2	0.3	0.7	-0.4	0.5	0.5	0.5	0.3	-0.8	-0.8
Locomotion velocity, NPP test	0.1	0.1	0.3	-0.1	0.2	0.2	0.2	0.0	-0.5	-0.6
Intraocular pressure	0.3	0.4	0.8	0.4	-0.4	-0.5	-0.5	-0.5	0.8	0.9
Delta distance traveled before/after self-admin	1.6	1.7	2.1	1.3	-1.3	-1.3	-1.3	-1.5	1.2	1.2
Delta ambulatory time before/after self-admin	1.5	1.6	2.0	1.4	-1.3	-1.3	-1.3	-1.4	1.2	1.2
Parametrial fat weight	0.5	1.1	1.2	1.0	-1.0	-1.0	-1.0	-1.0	1.1	1.0
Pavlov. Cond. lever latency	0.2	0.2	0.4	0.3	-0.4	-0.3	-0.4	-0.3	0.6	0.7
Pavlov. Cond. magazine entry latency	3.0	3.9	4.1	2.0	-2.0	-1.9	-2.0	-2.0	1.9	1.9
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.2	-0.2	0.1	0.1
Pavlov. Cond. index score	0.2	0.2	0.3	0.6	-0.5	-0.5	-0.5	-0.5	0.3	0.3
Pavlov. Cond. latency score	0.1	0.1	0.2	0.5	-0.4	-0.4	-0.4	-0.4	0.1	0.1
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.1	0.2	0.1	0.2	0.2	-0.5	-0.6
Pavlov. Cond. magazine entry number	0.6	0.8	0.8	-0.9	0.9	0.8	0.9	0.9	-0.8	-0.8
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.6	0.5	-0.6	-0.4	-0.6	-0.5	0.7	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	0.7	0.8	-0.8	-0.8	-0.8	-0.8	0.6	0.6
Pavlov. Cond. response bias	1.0	1.2	1.3	1.1	-1.1	-1.1	-1.1	-1.1	1.0	1.0
Pavlov. Cond. lever latency	0.8	1.1	1.4	-1.1	1.1	1.0	1.0	1.2	-1.1	-1.0
Pavlov. Cond. magazine entry latency	0.4	0.5	0.5	0.7	-0.7	-0.7	-0.7	-0.7	0.7	0.6
Pavlov. Cond. change in total contacts	0.9	1.2	1.3	1.1	-1.1	-1.1	-1.1	-1.1	1.1	1.1
Pavlov. Cond. index score	1.0	1.3	1.5	1.1	-1.1	-1.1	-1.1	-1.2	1.1	1.1
Pavlov. Cond. latency score	0.8	1.0	1.2	1.0	-1.0	-1.0	-1.0	-1.1	1.0	0.9
Pavlov. Cond. lever contacts	0.9	1.3	1.5	1.1	-1.1	-1.1	-1.1	-1.2	1.2	1.1
Pavlov. Cond. magazine entry number	0.7	0.8	0.9	-0.9	0.9	1.0	1.0	1.0	-0.9	-0.8
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.2	-0.5	0.4	0.4	0.4	0.4	-0.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	1.4	1.1	-1.1	-1.1	-1.1	-1.2	1.1	1.0
Pavlov. Cond. response bias	2.2	2.9	3.2	1.7	-1.7	-1.7	-1.7	-1.8	1.8	1.7
Time in closed arm before self-admin	1.4	1.6	2.2	-1.1	1.2	1.2	1.2	1.2	-1.5	-1.5
Time in closed arm after self-admin	0.0	0.0	0.0	0.1	-0.1	-0.0	-0.0	-0.1	0.1	0.2
Time in open arm before self-admin	1.2	1.3	1.5	1.1	-1.1	-1.2	-1.2	-0.9	1.2	1.2
Time in open arm after self-admin	0.6	0.7	0.9	-0.9	0.9	0.8	0.7	0.9	-0.8	-0.8
Bone: periosteal estimation	0.6	1.3	1.7	-1.0	1.1	1.2	1.1	1.1	-1.3	-1.3
Bone: periosteal perimeter	0.0	0.0	0.1	0.0	0.0	0.1	0.0	0.0	-0.3	-0.4
Bone: post-yield work	0.5	0.7	0.9	-0.9	0.8	1.0	0.8	0.8	-0.7	-0.7
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.2	0.1	0.2	0.2	0.2	-0.1	-0.0
Progressive ratio test 1 breakpoint	0.1	0.1	0.1	-0.3	0.2	0.3	0.3	0.3	-0.2	-0.2
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.0	0.0	0.1
Progressive ratio test 2 active lever presses	0.4	0.5	0.6	0.6	-0.7	-0.7	-0.7	-0.5	0.8	0.8
Progressive ratio test 2 breakpoint	0.4	0.4	0.5	0.6	-0.7	-0.7	-0.7	-0.5	0.7	0.6
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.1	0.2	-0.3	-0.2	-0.2	-0.2	0.2	0.2
Incentive Sensitization - Responses	0.5	0.5	0.8	0.6	-0.7	-0.8	-0.8	-0.4	0.9	0.8
Incentive Sensitization - Breakpoint	0.5	0.6	0.8	0.7	-0.7	-0.8	-0.8	-0.5	0.9	0.8
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.0	0.1	0.0
Progressive ratio	0.1	0.1	0.2	-0.4	0.4	0.3	0.4	0.3	-0.3	-0.2
Food seeking constrained by brief footshock	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.3	0.2	0.2
Seeking ratio, punishment vs. effort	0.1	0.1	0.1	0.4	-0.3	-0.3	-0.3	-0.3	0.2	0.2
Retroperitoneal fat weight	0.3	0.9	1.1	-1.0	1.0	1.0	0.9	0.9	-0.9	-0.8
Reaction time number correct	0.2	0.2	0.4	-0.6	0.5	0.5	0.5	0.7	-0.2	-0.1
Reaction time mean minus median	0.8	1.1	1.2	1.0	-1.0	-1.1	-1.1	-1.1	1.0	1.0
Reaction time mean minus median AUC	0.1	0.1	0.2	-0.1	0.2	0.1	0.2	0.1	-0.4	-0.5
Reaction time num false alarms	0.0	0.0	0.0	-0.1	0.1	0.0	0.0	0.2	0.2	0.2
Reaction time num false alarms AUC	0.0	0.0	0.1	-0.2	0.1	0.1	0.1	0.2	0.2	0.2
Reaction time trials correct on left	0.2	0.2	0.4	-0.6	0.5	0.5	0.5	0.7	-0.2	-0.1
Reaction time trials on left	0.2	0.3	0.5	-0.7	0.5	0.6	0.5	0.7	-0.2	-0.1
Reaction time mean	0.0	0.1	0.1	-0.2	0.2	0.2	0.2	0.0	-0.3	-0.4
Reaction time mean AUC	0.1	0.1	0.2	-0.3	0.3	0.3	0.3	0.1	-0.4	-0.5
Median of all reaction times	0.4	0.6	0.8	-0.7	0.8	0.8	0.7	0.6	-0.9	-0.9
Reaction time omissions	0.2	0.3	0.4	0.6	-0.5	-0.6	-0.6	-0.4	0.4	0.4
Reaction time false alarm rate	0.0	0.0	0.0	-0.1	0.1	0.1	0.1	0.1	-0.0	-0.0
Reaction time premature initiation rate	1.5	2.0	2.2	1.3	-1.4	-1.3	-1.4	-1.5	1.5	1.5
Reaction time premature initiations	1.2	1.7	2.4	1.1	-1.3	-1.1	-1.2	-1.2	1.5	1.5
Std. dev. reaction times	0.2	0.2	0.3	0.5	-0.5	-0.6	-0.5	-0.6	0.4	0.4
Reaction time trials completed	0.2	0.3	0.5	-0.7	0.5	0.6	0.5	0.7	-0.2	-0.1
Reaction time trials AUC	0.1	0.2	0.4	-0.6	0.4	0.4	0.4	0.6	-0.0	0.0
Run reversals in cocaine runway, females	0.3	0.2	0.3	0.6	-0.5	-0.5	-0.5	-0.5	0.4	0.4
Run reversals in cocaine runway, males	0.9	0.9	1.1	1.0	-1.0	-0.9	-0.9	-1.0	0.8	0.8
Latency to leave start box in cocaine runway	0.5	0.5	0.7	0.9	-0.8	-0.8	-0.9	-0.7	0.5	0.4
Latency to leave start box in cocaine runway, F	0.2	0.2	0.7	-0.2	0.2	0.4	0.2	0.4	-0.7	-0.8
Latency to leave start box in cocaine runway, M	4.0	3.9	4.3	1.9	-1.9	-2.0	-2.0	-1.9	2.1	2.1
Std. dev. time between licks in bursts	0.5	0.6	0.7	0.8	-0.8	-0.8	-0.8	-0.9	0.6	0.5
Total sessions with >9 infusions	0.0	0.0	0.1	-0.1	-0.0	0.1	0.1	0.3	-0.2	-0.2
Short access day 1 total inactive lever presses	0.0	0.0	0.1	0.2	-0.3	-0.2	-0.2	-0.1	0.2	0.2
Short access day 10 total inactive lever presses	0.1	0.1	0.2	0.3	-0.3	-0.4	-0.4	-0.2	0.5	0.4
Short access day 1 total infusions	0.0	0.0	0.1	0.2	-0.3	-0.1	-0.1	-0.2	-0.0	-0.0
Short access day 10 total infusions	0.0	0.0	0.1	0.2	-0.3	-0.2	-0.2	-0.1	0.3	0.3
Short access total infusions	0.0	0.0	0.0	-0.0	-0.1	0.0	0.0	0.1	-0.1	-0.1
Short access day 1 locomotion	0.7	0.7	1.0	1.0	-1.0	-0.9	-0.9	-0.9	0.7	0.7
Short access day 10 total locomotion	4.9	5.4	6.1	2.3	-2.5	-2.4	-2.4	-2.0	2.4	2.3
Short access total locomotion	0.9	1.0	1.3	1.0	-1.1	-1.0	-1.0	-0.8	1.0	0.9
One hour access (0.3 mA shock)	0.1	0.2	0.2	-0.4	0.3	0.4	0.4	0.4	-0.4	-0.4
Compulsive drug intake	1.5	1.5	1.7	-1.2	1.2	1.2	1.2	1.3	-1.3	-1.3
One hour access (shock baseline)	0.2	0.2	0.3	0.3	-0.5	-0.4	-0.4	-0.4	0.5	0.5
Social response proportion	0.3	0.4	0.6	0.7	-0.6	-0.6	-0.6	-0.7	0.4	0.4
Social responses	5.8	7.5	8.6	2.9	-2.8	-2.8	-2.8	-2.9	2.5	2.4
Social time	0.5	0.7	0.9	-0.9	0.9	0.8	0.9	0.7	-0.8	-0.8
Soleus weight	8.9	26.0	28.0	-5.3	5.2	5.2	5.2	5.2	-4.8	-4.8
Bone: stiffness	3.5	5.5	6.2	-2.3	2.3	2.5	2.3	2.3	-2.3	-2.3
Tibialis anterior weight	1.1	3.9	4.8	-2.0	2.1	1.8	2.0	2.2	-1.8	-1.8
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.5	-0.4	-0.5	-0.5	-0.3	0.1	0.1
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.6	0.4	-0.5	-0.4	-0.4	-0.6	0.7	0.8
Time to tail flick, test, before self-admin	0.0	0.0	0.1	0.2	-0.2	-0.1	-0.2	-0.2	-0.1	-0.1
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.3	0.1	0.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.4	0.3	0.4	0.4	0.1	0.0	0.1
Delta time to tail flick, test, before/after SA	0.3	0.3	0.4	0.4	-0.4	-0.5	-0.5	-0.4	0.6	0.6
Tibia length	1.0	2.9	3.5	1.7	-1.7	-1.8	-1.7	-1.9	1.6	1.6
Ambulatory time before self-admin	0.3	0.4	0.6	-0.6	0.6	0.5	0.5	0.8	-0.6	-0.6
Ambulatory time after self-admin	0.3	0.4	0.5	0.7	-0.6	-0.7	-0.7	-0.5	0.6	0.5
Bone: tissue strength	1.9	1.9	2.1	-1.3	1.4	1.4	1.4	1.3	-1.4	-1.4
Total heroin consumption	2.0	2.3	2.5	1.6	-1.6	-1.6	-1.6	-1.5	1.4	1.4
Bone: trabecular number	0.2	0.3	0.5	0.7	-0.6	-0.7	-0.6	-0.5	0.2	0.1
Bone: trabecular spacing	0.1	0.1	0.3	-0.3	0.1	0.1	0.1	0.0	0.4	0.5
Bone: trabecular thickness	0.7	0.9	2.2	-0.5	0.7	0.7	0.7	0.7	-1.3	-1.5
Bone: trabecular tissue density	1.2	1.7	2.3	-1.4	1.4	1.5	1.4	1.3	-1.2	-1.1
Water consumed over 24 hours	0.9	1.1	1.3	-0.9	1.0	1.0	1.0	1.1	-1.1	-1.1
Number of responses in last shaping day	0.2	0.2	0.4	0.4	-0.6	-0.4	-0.4	-0.3	0.4	0.4