Hub : Genes

Itpka

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Itpka 0.05 0.02 1.3e-08 0.04 0.05 0.05 0.06 1.7e-07 1.6e-08 6.3e-08 8.3e-09
2 PL mRNA stability Itpka 0.08 0.04 7.9e-10 0.06 0.09 0.08 0.08 4.0e-07 1.4e-09 4.1e-09 3.5e-09
3 Brain isoform ratio NM_031045.2 0.04 0.03 5.6e-04 0.02 0.02 0.02 0.02 3.1e-03 2.7e-03 3.7e-03 3.6e-03
4 BLA mRNA stability Itpka 0.08 0.05 4.2e-04 0.03 0.02 0.02 0.02 1.5e-02 3.3e-02 3.9e-02 4.8e-02
5 IL mRNA stability Itpka 0.13 0.08 8.4e-03 0.04 0.02 0 0.01 4.7e-02 9.1e-02 3.0e-01 2.3e-01
6 Brain mRNA stability Itpka 0.04 0.02 2.4e-04 0.05 0.04 0.04 0.05 9.3e-06 1.6e-04 2.3e-04 1.9e-05
7 Liver gene expression Itpka 0.03 0.02 5.6e-03 0.01 0.01 0.01 0.01 2.7e-02 3.1e-02 1.5e-02 2.6e-02
8 OFC mRNA stability Itpka 0.25 0.13 1.4e-04 0.19 0.18 0.15 0.18 2.4e-05 4.7e-05 2.2e-04 4.2e-05
9 Eye gene expression Itpka 0.48 0.2 4.2e-03 0.02 0.06 0.09 0.06 1.7e-01 4.3e-02 1.9e-02 4.3e-02
10 NAcc gene expression Itpka 0.02 0.01 5.6e-03 0 0.01 0 0 8.3e-02 1.1e-02 1.5e-01 5.0e-02
11 Brain isoform ratio XM_039105917.2 0.04 0.03 5.0e-04 0.02 0.02 0.02 0.02 4.9e-03 3.0e-03 2.9e-03 3.6e-03
12 Brain alternative TSS XM_039105917.2 0.05 0.04 1.2e-04 0.03 0.03 0.03 0.03 7.2e-04 9.8e-04 4.2e-04 8.6e-04
13 PL gene expression Itpka 0.03 0.02 3.5e-03 0.01 0.02 0.01 0.01 3.1e-02 5.2e-03 2.6e-02 1.0e-02
14 Brain alternative TSS NM_031045.2 0.05 0.03 1.7e-04 0.03 0.03 0.03 0.03 8.1e-04 1.1e-03 5.1e-04 9.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.71.32.3-1.4-1.51.2-1.3-1.1-1.50.9-1.0-0.30.3-1.3-1.30.31.1
Area under the delay curve2.73.26.1-1.2-2.01.2-1.9-2.3-1.70.7-2.5-0.51.3-2.0-2.22.02.2
BMI with tail3.712.819.1-4.4-4.44.4-4.3-4.2-4.11.2-4.3-2.32.6-3.6-3.42.42.6
BMI without tail4.313.123.8-4.9-4.94.5-4.5-4.7-4.51.7-4.2-1.92.1-3.3-2.81.71.6
Body weight4.218.331.4-5.6-5.15.4-5.1-5.1-5.20.7-4.7-3.33.3-4.1-3.82.92.7
Weight adjusted by age1.11.62.3-1.3-1.01.4-1.4-1.4-1.3-1.3-1.2-1.31.5-1.0-1.01.40.8
Bone surface0.50.91.9-1.4-1.21.4-0.9-0.7-1.31.3-0.7-0.40.2-0.8-0.9-0.00.6
Bone volume0.71.22.3-1.4-1.31.5-1.1-0.9-1.21.1-1.1-0.50.3-1.2-1.30.11.1
Breakpoint value in progressive ratio session0.50.62.70.60.3-0.50.70.80.81.60.31.1-1.10.30.0-1.00.0
Number of licking bursts0.50.83.50.60.1-0.60.60.80.71.90.41.5-1.30.20.0-1.20.0
Context. condit. distance diff. score0.70.92.3-1.5-1.51.4-1.3-1.2-1.00.7-0.9-0.0-0.0-0.6-0.2-0.5-0.5
Locomotion velocity, session 11.51.64.42.01.5-2.11.51.41.3-0.31.40.7-0.71.11.2-0.2-0.7
Locomotion distance, session 10.81.02.61.41.0-1.60.91.00.8-0.61.40.7-0.60.91.1-0.2-1.0
Locomotion velocity, session 21.01.22.4-0.7-1.60.4-1.4-1.3-1.51.2-1.2-0.00.5-1.2-0.91.00.6
Locomotion distance, session 20.50.71.40.90.4-1.10.50.90.20.71.21.1-0.90.71.0-0.7-1.1
Locomotion velocity, session 30.30.41.00.3-0.7-0.1-0.5-0.4-0.40.8-1.00.4-0.1-0.8-0.90.50.9
Locomotion distance, session 30.70.74.30.7-0.4-0.30.00.20.32.1-0.41.5-1.20.10.1-1.1-0.4
Stereotopy head waving bouts, day 33.84.45.9-2.1-2.02.1-2.3-2.3-2.3-1.3-2.4-2.22.2-2.1-2.02.21.7
Stereotopy head waving duration, day 34.85.77.1-2.2-2.42.1-2.6-2.5-2.6-1.1-2.7-2.12.2-2.7-2.62.52.5
Locomotion velocity, session 70.20.20.6-0.1-0.70.2-0.6-0.6-0.40.4-0.60.3-0.2-0.10.2-0.3-0.7
Locomotion distance, session 70.60.73.10.30.2-0.30.40.30.40.50.60.9-0.90.91.3-1.3-1.8
Stereotopy head waving bouts, day 70.10.10.70.20.30.00.10.10.10.0-0.3-0.40.5-0.2-0.50.50.8
Stereotopy head waving duration, day 70.30.31.2-0.00.30.4-0.0-0.10.0-0.4-0.6-0.90.8-0.4-0.80.81.1
Locomotion velocity, session 82.12.55.2-1.6-2.21.4-2.3-2.0-1.9-0.0-1.8-0.61.0-1.8-1.41.21.0
Locomotion distance, session 80.30.51.5-0.7-1.10.4-0.8-0.6-0.80.7-0.10.6-0.5-0.00.5-0.7-1.2
Degree of sensitization distance0.80.83.80.01.1-0.20.80.70.7-1.91.1-0.70.20.91.0-0.3-0.8
Degree of sensitization stereotypy0.30.31.00.61.0-0.30.80.70.90.10.4-0.10.00.70.4-0.2-0.2
Conditioned locomotion1.21.42.6-1.6-1.61.4-1.4-1.4-1.30.3-1.2-0.50.5-1.4-1.30.41.1
Cocaine response after cond. corrected1.31.64.81.50.3-1.41.00.91.02.20.12.2-2.00.1-0.2-1.40.4
Cocaine response after cond. not corrected1.41.75.21.70.4-1.71.11.00.92.00.32.3-2.00.1-0.1-1.30.3
Cocaine response before conditioning0.20.31.30.20.3-0.4-0.10.0-0.3-1.10.5-0.40.50.30.60.6-0.7
Saline control response2.33.17.0-2.1-1.02.1-1.7-1.4-1.7-2.2-1.1-2.62.3-1.3-1.11.81.0
Bone: connectivity density0.40.71.9-1.1-0.51.0-0.7-0.6-1.4-0.2-0.4-1.21.0-0.6-0.50.90.4
Bone: cortical apparent density1.41.93.71.31.7-1.01.91.81.9-0.51.30.9-1.31.30.9-1.6-0.7
Bone: cortical area1.62.43.7-1.9-1.81.9-1.8-1.6-1.5-0.0-1.7-1.21.2-1.7-1.81.11.6
Bone: cortical porosity0.50.52.10.7-0.5-1.1-0.2-0.1-0.11.40.21.5-0.9-0.4-0.2-0.20.2
Bone: cortical porosity0.40.41.0-0.0-1.0-0.3-0.8-0.8-0.70.8-0.50.6-0.2-0.8-0.60.40.5
Bone: cortical thickness1.32.13.2-1.6-1.71.5-1.8-1.6-1.6-0.0-1.6-0.91.1-1.6-1.61.21.4
Bone: cortical thickness0.50.61.70.1-0.5-0.00.20.20.21.3-0.41.1-1.1-0.8-1.1-0.91.2
Bone: cortical tissue density1.31.73.61.31.7-1.01.91.71.9-0.51.30.9-1.21.20.8-1.6-0.5
Condit. Reinf. active minus inactive responses1.21.33.30.61.8-0.21.21.01.2-1.41.1-1.00.71.61.50.1-1.2
Condit. Reinf. active-inactive response ratio0.30.31.1-0.50.20.9-0.2-0.30.0-0.7-0.4-1.11.00.1-0.10.60.1
Condit. Reinf. active responses2.83.58.01.22.8-0.82.11.81.9-1.82.0-1.00.42.62.6-0.4-2.3
Condit. Reinf. inactive responses2.93.67.21.62.5-1.42.22.01.8-0.92.10.1-0.62.62.7-1.2-2.6
Incentive salience index mean2.32.96.81.22.6-0.91.81.71.6-1.82.0-0.90.52.32.2-0.1-1.8
Condit. Reinf. lever presses1.92.65.61.12.4-1.01.61.71.1-1.82.1-0.90.62.22.20.1-1.9
Condit. Reinf. active minus inactive responses0.30.41.5-1.10.11.1-0.1-0.1-0.4-1.00.2-1.20.80.10.20.1-0.2
Condit. Reinf. active-inactive response ratio0.20.20.8-0.90.10.9-0.0-0.1-0.0-0.40.1-0.60.40.20.2-0.1-0.3
Condit. Reinf. active responses0.60.93.1-1.40.11.5-0.4-0.3-0.6-1.4-0.1-1.81.3-0.1-0.20.40.1
Condit. Reinf. inactive responses0.91.24.2-1.10.11.3-0.5-0.4-0.6-2.0-0.4-2.01.6-0.5-0.71.10.7
Condit. Reinf. lever presses1.42.06.4-1.40.01.7-0.7-0.7-1.0-2.0-0.7-2.52.1-0.7-0.91.71.1
Condit. Reinf. lever reinforcers received0.71.03.8-1.30.41.4-0.2-0.2-0.5-1.80.1-2.01.40.10.10.6-0.1
Conditioned reinforcement - actives0.10.10.40.60.4-0.70.50.20.4-0.20.40.4-0.30.0-0.0-0.10.4
Conditioned reinforcement - inactives0.20.31.1-0.0-0.4-0.1-0.0-0.20.11.0-0.10.8-0.70.30.4-0.8-0.6
Conditioned locomotion0.40.52.20.10.2-0.1-0.3-0.5-0.2-1.4-0.5-1.11.20.10.11.50.1
Patch foraging indifference point 0 sec3.56.512.3-2.0-1.32.3-2.3-2.4-2.2-2.9-2.3-3.53.4-2.2-2.23.42.4
Patch foraging indifference point AUC1.52.13.82.01.9-1.71.91.71.9-0.81.40.9-0.91.41.2-0.9-0.9
Delay disc. indifference point, 0s delay0.80.93.1-0.2-0.10.4-0.4-0.8-0.4-1.2-1.0-1.11.5-0.6-0.91.81.2
Delay disc. indifference point, 16s delay1.01.13.3-0.1-1.00.2-0.8-1.1-0.70.6-1.60.20.4-1.3-1.61.11.8
Delay disc. indifference point, 2s delay0.40.41.2-0.9-0.61.0-0.8-1.1-0.6-0.1-0.9-0.40.7-0.3-0.30.5-0.0
Delay disc. indifference point, 24s delay0.30.41.41.20.8-1.10.60.50.6-0.10.50.3-0.10.50.30.3-0.0
Delay disc. indifference point, 4s delay1.21.32.1-0.9-1.40.7-1.3-1.4-1.10.4-1.3-0.20.8-1.3-1.31.31.3
Delay disc. indifference point, 8s delay5.36.211.5-2.0-2.82.0-2.7-2.9-2.40.7-3.4-1.21.9-2.8-3.12.62.9
Indifference point function ln k2.13.67.8-2.4-2.82.1-2.4-2.3-2.31.4-2.1-0.60.6-2.0-1.70.61.1
Indifference point function log k2.13.67.8-2.4-2.82.1-2.4-2.3-2.31.4-2.1-0.60.6-2.0-1.70.61.1
Patch foraging total patch changes 0 sec3.05.610.7-1.8-1.22.2-2.1-2.2-2.0-2.5-2.2-3.33.2-2.1-2.23.12.4
Patch foraging total patch changes 12 sec0.70.96.00.10.80.40.1-0.10.3-2.40.2-1.51.4-0.0-0.11.10.4
Patch foraging total patch changes 18 sec0.40.62.20.91.2-0.50.90.40.8-1.50.7-0.40.30.60.60.1-0.4
Patch foraging total patch changes 24 sec1.32.23.2-1.4-1.11.4-1.3-1.6-1.6-1.0-1.4-1.81.6-1.5-1.61.71.6
Patch foraging total patch changes 6 sec0.30.41.70.30.70.10.0-0.20.4-1.3-0.2-1.11.10.20.10.90.1
Patch foraging time to switch 0 sec0.40.82.30.51.5-0.30.80.70.7-1.41.0-1.00.81.00.80.5-0.4
Patch foraging water rate 0 sec0.30.61.4-1.0-1.11.2-0.7-0.7-0.60.5-1.2-0.1-0.2-0.9-0.9-0.40.4
Patch foraging water rate 12 sec0.71.59.00.1-0.7-0.10.20.20.23.0-0.01.9-1.90.00.0-1.9-0.3
Patch foraging water rate 18 sec0.91.36.5-0.6-1.60.5-0.9-0.8-0.82.5-1.11.1-0.8-1.1-1.2-0.41.0
Patch foraging water rate 24 sec0.50.64.0-0.3-0.60.7-0.0-0.20.12.0-0.80.8-1.0-0.2-0.4-1.30.1
Patch foraging water rate 6 sec1.62.35.81.10.6-1.01.31.51.52.21.12.1-2.31.00.8-2.4-0.9
Seeking ratio, delayed vs. immediate footshock0.20.21.2-0.6-0.10.40.20.20.40.00.50.5-0.50.20.2-1.1-0.6
Distance traveled before self-admin0.40.61.1-1.0-1.00.8-0.7-0.7-0.80.9-0.7-0.40.2-0.9-0.80.30.7
Distance traveled after self-admin0.10.10.8-0.30.00.30.10.30.30.90.1-0.0-0.3-0.0-0.2-0.40.3
Extensor digitorum longus weight0.41.52.5-0.9-1.61.1-1.4-1.1-1.61.2-1.5-0.40.4-1.5-1.50.61.2
Bone: elastic displacement0.20.20.80.10.00.0-0.3-0.20.0-0.9-0.3-0.40.6-0.5-0.60.70.8
Bone: elastic work1.01.32.4-0.9-0.61.2-1.0-0.8-0.6-1.0-1.0-1.41.3-1.2-1.41.21.6
Bone: endosteal estimation0.10.31.9-0.2-0.40.20.10.0-0.01.4-0.10.6-0.8-0.1-0.1-0.9-0.0
Bone: endosteal perimeter0.00.10.3-0.1-0.10.10.10.00.40.6-0.00.2-0.30.10.1-0.5-0.0
Epididymis fat weight0.41.43.0-1.1-1.70.9-1.6-1.6-1.60.6-1.4-0.30.7-1.3-0.91.00.4
Delta time in closed arm before/after self-admin0.50.52.40.10.1-0.20.30.30.20.40.60.6-0.50.91.2-0.9-1.5
Delta time in open arm before/after self-admin0.80.82.7-1.0-1.10.9-0.6-0.6-0.41.6-0.70.9-0.8-0.7-0.7-1.10.4
Diff in mean of infusions in LGA sessions0.40.51.00.31.0-0.10.60.60.5-0.70.7-0.60.50.91.00.1-1.0
Delay discount exponential model param2.22.44.41.11.8-1.01.72.01.5-0.82.10.3-1.01.81.9-1.7-1.8
Extinction: sum of active levers before priming0.40.51.21.10.7-1.00.60.80.90.20.60.7-0.50.50.4-0.1-0.2
Active lever presses in extinction session 60.10.10.50.60.1-0.70.10.20.20.00.20.5-0.20.10.10.1-0.1
Bone: final force0.30.51.8-1.1-0.81.3-0.8-0.8-0.7-0.2-0.8-0.80.5-0.5-0.40.00.1
Bone: final moment0.30.41.5-1.0-0.71.2-0.7-0.7-0.5-0.2-0.8-0.70.5-0.5-0.50.00.3
Food consumed during 24 hour testing period0.40.51.80.3-0.1-0.50.30.70.11.40.91.1-1.20.10.2-1.1-0.3
Glucose0.81.23.5-1.1-1.71.2-1.4-1.3-1.01.9-1.40.6-0.1-0.7-0.5-0.3-0.3
Heart weight2.74.28.5-2.9-2.82.6-2.7-2.4-2.90.5-1.9-1.41.3-1.9-1.51.10.8
Delay discount hyperbolic model param2.02.34.21.21.8-1.11.72.01.5-0.62.00.4-1.11.71.8-1.6-1.7
Intermittent access intake day 1-15 change0.61.27.8-0.4-1.10.3-0.2-0.3-0.32.8-0.51.4-1.6-0.1-0.1-1.5-0.3
Intermittent access intake escalation0.61.16.9-0.7-1.30.6-0.4-0.6-0.52.6-0.91.2-1.3-0.5-0.6-1.20.3
Intermittent access intake escalation 22.02.311.30.4-1.0-0.70.30.10.13.4-0.12.7-2.6-0.4-0.4-2.20.2
Intermitt. access day 1 inactive lever presses0.51.83.5-1.8-1.11.5-1.6-1.3-1.8-1.1-0.7-1.91.7-1.0-0.61.40.5
Intermitt. access day 15 inactive lever presses0.10.30.9-0.9-0.80.8-0.8-0.5-0.70.1-0.2-0.30.2-0.5-0.3-0.1-0.0
Intermitt. access escalation Index0.20.31.4-0.60.31.0-0.1-0.1-0.1-0.5-0.4-1.20.80.20.10.2-0.1
Intermittent access day 1 total infusions0.10.20.90.50.4-0.30.1-0.00.4-1.0-0.1-0.40.6-0.2-0.30.70.7
Intermittent access day 15 total infusions0.20.30.9-0.5-0.70.6-0.4-0.6-0.31.0-0.70.2-0.2-0.4-0.5-0.30.4
Intermittent access terminal intake (last 3 days)0.60.83.9-0.2-0.90.2-0.2-0.4-0.12.0-0.61.1-1.1-0.8-0.8-0.90.8
Intermittent access total infusions0.20.21.0-0.2-0.40.3-0.3-0.3-0.10.4-0.40.1-0.0-0.7-0.80.01.0
Intermittent access day 1 locomotion1.31.63.8-0.8-0.80.8-1.3-1.3-1.1-1.3-1.2-1.51.7-1.1-1.02.01.1
Intermittent access day 15 total locomotion0.30.62.6-0.8-1.20.6-0.7-0.8-0.51.6-0.70.6-0.5-0.6-0.6-0.50.3
Intermittent access total locomotion0.30.30.7-0.4-0.70.2-0.6-0.8-0.40.3-0.7-0.10.3-0.8-0.80.50.8
Intermittent access standard deviation0.30.63.9-0.2-0.80.1-0.3-0.0-0.42.0-0.11.1-1.2-0.1-0.0-1.1-0.2
Left kidney weight2.19.720.2-4.0-4.43.5-4.5-4.1-4.10.2-3.1-1.82.3-2.8-2.02.20.7
Right kidney weight3.415.428.3-5.0-5.24.3-5.3-5.3-5.1-0.3-4.1-2.73.1-3.6-2.63.11.3
Cocaine induced anxiety1.11.63.0-1.3-1.00.9-1.5-1.4-1.6-1.7-0.6-1.61.7-1.0-0.41.60.2
Post-drug Anxiety1.21.22.3-1.5-1.11.0-1.5-1.4-1.5-1.2-0.3-1.21.2-0.50.30.9-0.9
Baseline Anxiety0.20.31.2-0.10.10.00.20.30.20.30.40.4-0.50.70.8-0.8-1.1
Tail length1.14.410.9-3.3-3.12.8-2.7-2.7-2.90.6-2.1-1.00.8-1.8-1.20.30.2
Length with tail1.04.29.0-3.0-2.52.8-2.6-2.4-2.7-0.3-2.0-1.91.6-1.7-1.41.20.7
Length without tail0.61.83.0-1.6-1.61.6-1.6-1.4-1.70.4-1.4-1.00.9-1.4-1.40.91.1
Times rat made contact with spout0.60.71.6-0.7-0.60.7-0.9-0.3-0.8-0.4-0.4-0.80.9-1.0-1.11.01.3
Lifetime Intake0.30.32.10.1-0.30.1-0.2-0.2-0.00.5-0.50.10.0-0.9-1.10.21.5
Liver weight, left2.84.610.1-3.2-2.32.9-2.3-2.2-2.60.2-2.0-2.01.7-2.1-2.11.31.8
Liver weight, right2.64.66.1-2.4-2.22.4-2.4-2.2-2.4-0.4-2.5-1.81.8-2.3-2.41.82.1
Locomotor activity0.10.20.80.40.4-0.60.30.40.2-0.90.70.00.00.20.20.2-0.0
Locomotor testing distance0.20.41.20.90.7-0.90.60.50.6-1.10.70.0-0.00.40.50.1-0.3
Locomotor testing rearing1.02.13.71.51.7-1.51.51.71.2-0.41.90.7-0.81.61.8-1.0-1.7
Locomotion in novel chamber0.40.50.9-0.6-0.50.8-0.8-0.5-0.4-1.0-0.7-0.70.8-0.7-0.90.80.9
Locomotion in novel chamber post-restriction0.71.12.9-1.7-1.41.4-0.9-1.2-1.01.0-1.2-0.20.0-1.0-1.1-0.10.8
Fecal boli incidents, locomotor time 10.30.41.31.10.5-1.00.60.60.80.30.20.5-0.5-0.1-0.4-0.00.9
Change in fecal boli incidents, locomotor task1.31.22.8-1.6-1.61.5-1.5-1.4-1.70.7-1.0-0.30.5-0.8-0.50.2-0.2
Time >=10cm from walls, locomotor time 10.30.31.10.40.2-0.20.40.40.31.00.20.9-0.80.50.4-0.9-0.5
Bouts of movement, locomotor time 12.42.85.62.21.8-2.22.02.42.20.72.01.5-1.41.20.8-0.80.0
Total resting periods, locomotor time 12.73.06.22.22.1-2.22.12.52.20.32.31.3-1.21.41.1-0.9-0.4
Rest time, locomotor task time 10.10.10.40.30.5-0.10.30.60.20.20.60.10.10.20.2-0.1-0.1
Distance moved, locomotor task time 10.10.21.70.40.5-0.10.40.10.4-1.3-0.2-0.50.20.1-0.10.20.2
Vertical activity count, locomotor time 10.00.10.2-0.5-0.10.40.0-0.10.2-0.3-0.3-0.3-0.1-0.2-0.4-0.20.5
Time >=10cm from walls, locomotor time 25.17.515.2-3.9-2.83.7-3.2-3.1-3.1-0.7-2.7-2.72.8-2.2-1.92.21.3
Bouts of movement, locomotor time 20.20.31.5-0.5-0.00.7-0.10.2-0.10.8-0.3-0.60.2-0.6-0.90.11.2
Total resting periods, locomotor time 20.20.31.4-0.40.10.60.10.30.10.8-0.2-0.40.1-0.5-0.9-0.11.2
Rest time, locomotor task time 23.84.88.22.92.3-2.62.32.42.41.02.52.1-1.72.22.1-1.5-1.8
Distance moved, locomotor task time 22.02.43.3-1.8-1.21.8-1.5-1.7-1.4-1.8-1.7-1.81.7-1.2-1.21.51.0
Vertical activity count, locomotor time 22.23.06.5-2.5-1.62.5-1.8-1.8-1.6-0.9-1.9-1.81.6-1.5-1.61.01.4
Light reinforcement 11.74.315.9-1.50.52.0-1.0-0.6-0.7-4.0-0.3-3.83.5-0.5-0.62.80.9
Light reinforcement 20.81.22.81.01.6-0.81.31.61.4-1.51.7-0.20.10.80.6-0.1-0.0
Bone: marrow area0.10.31.7-0.3-0.50.3-0.1-0.1-0.11.3-0.10.5-0.7-0.2-0.2-0.80.0
Bone: maximum diameter0.61.12.4-1.5-1.11.5-1.0-1.0-0.90.4-1.2-1.00.8-0.9-1.00.61.0
Bone: maximum force1.22.14.1-2.0-1.62.0-1.7-1.6-1.6-0.5-1.4-1.61.4-1.2-1.11.00.7
Bone: maximum moment1.01.83.3-1.7-1.41.8-1.6-1.5-1.4-0.5-1.3-1.41.2-1.2-1.10.90.8
Mean time between licks in bursts0.20.51.81.10.3-1.30.70.60.50.20.71.0-1.10.20.3-0.6-0.1
Mean num. licks in bursts0.91.33.7-1.1-0.41.0-1.0-0.9-1.0-1.9-0.6-1.81.7-0.8-0.61.50.6
Cd content in liver0.30.30.6-0.6-0.50.8-0.5-0.6-0.7-0.3-0.7-0.50.4-0.6-0.70.30.6
Co content in liver0.70.82.3-0.0-0.90.1-0.6-0.6-0.71.5-1.00.5-0.2-1.2-1.40.31.5
Cu content in liver0.81.02.30.90.4-0.90.90.71.00.60.81.4-1.50.80.8-1.5-0.9
Fe content in liver2.63.26.51.52.5-1.22.42.32.0-0.72.3-0.0-0.82.22.0-1.4-1.6
K content in liver0.60.53.6-0.5-0.90.3-0.3-0.3-0.61.9-0.30.7-0.7-0.6-0.6-0.50.5
Mg content in liver1.51.58.3-0.7-1.40.7-0.6-0.6-0.72.9-1.01.1-1.1-1.1-1.3-0.91.1
Mn content in liver1.61.72.8-1.6-1.51.5-1.6-1.7-1.5-0.5-1.6-1.21.1-1.3-1.11.00.8
Na content in liver0.90.92.10.70.8-1.01.11.10.50.61.40.8-1.01.11.1-1.0-0.9
Rb content in liver3.43.97.4-2.0-2.72.0-2.4-2.5-2.42.1-2.6-0.40.8-2.0-1.80.91.2
Se content in liver0.00.00.1-0.0-0.20.2-0.1-0.1-0.00.3-0.20.2-0.2-0.1-0.0-0.3-0.1
Sr content in liver0.00.00.10.20.0-0.3-0.10.1-0.1-0.30.20.10.0-0.1-0.10.30.3
Zn content in liver1.71.84.20.80.9-1.01.61.41.51.21.41.6-1.91.21.0-2.0-0.9
Bone: minimum diameter1.83.35.0-1.7-2.11.6-2.1-2.2-2.0-0.1-2.2-1.21.4-2.0-2.01.71.9
Time in familiar zone, hab. session 11.31.22.21.21.0-1.31.31.51.11.01.21.3-1.40.50.2-1.10.3
Time in novel zone, hab. session 11.71.73.0-1.5-1.11.7-1.5-1.7-1.1-1.0-1.6-1.61.6-0.7-0.51.1-0.0
Total zone transitions, hab. session 10.20.31.10.50.6-0.90.60.80.10.31.00.4-0.40.30.3-0.1-0.1
Total locomotion distance, hab. session 10.10.21.00.40.5-0.80.40.60.10.01.00.2-0.10.20.30.2-0.1
Locomotion velocity, hab. session 10.30.41.60.60.7-1.00.60.80.2-0.41.30.10.00.40.50.3-0.2
Time in familiar zone, hab. session 20.20.21.1-0.10.10.20.20.2-0.00.2-0.3-0.3-0.1-0.5-0.8-0.01.1
Time in novel zone, hab. session 20.40.41.0-0.6-0.80.5-1.0-1.0-0.6-0.5-0.7-0.30.7-0.20.10.6-0.5
Total zone transitions, hab. session 20.20.31.10.3-0.1-0.80.20.4-0.21.10.70.8-0.7-0.10.0-0.30.0
Total locomotion distance, hab. session 20.00.00.3-0.1-0.0-0.2-0.10.1-0.20.20.60.10.1-0.00.20.2-0.1
Locomotion velocity, hab. session 20.10.10.60.00.2-0.30.10.3-0.10.00.80.00.20.10.30.2-0.2
Novel to familiar place preference ratio1.51.63.3-1.5-0.81.6-1.2-1.3-0.8-1.6-1.1-1.81.7-0.8-0.81.30.7
Novelty place preference1.41.63.1-1.5-0.81.5-1.2-1.4-0.7-1.6-1.1-1.71.6-0.8-0.71.30.7
Time in novel zone, NPP test1.31.42.8-1.4-0.71.5-1.1-1.3-0.6-1.6-1.1-1.71.5-0.7-0.71.20.6
Total zone transitions, NPP test1.11.65.01.20.1-1.70.71.10.32.21.32.0-1.70.50.8-1.2-0.9
Total locomotion distance, NPP test0.30.41.50.4-0.5-0.9-0.30.1-0.31.10.71.2-0.7-0.10.4-0.3-0.6
Locomotion velocity, NPP test0.30.41.50.5-0.5-1.0-0.30.1-0.41.10.71.2-0.7-0.00.4-0.2-0.6
Intraocular pressure0.50.72.01.41.3-1.01.00.91.3-1.10.3-0.10.00.50.10.30.5
Delta distance traveled before/after self-admin0.20.20.60.50.8-0.20.40.60.6-0.60.4-0.20.00.40.2-0.10.1
Delta ambulatory time before/after self-admin0.50.61.60.71.3-0.50.70.90.9-1.30.9-0.50.30.90.80.0-0.6
Parametrial fat weight0.30.72.6-0.50.20.3-0.4-0.2-0.7-1.60.4-1.31.30.30.61.1-0.5
Pavlov. Cond. lever latency0.30.41.3-0.3-0.60.6-0.3-0.5-0.20.9-1.10.2-0.4-0.7-0.9-0.40.9
Pavlov. Cond. magazine entry latency1.21.68.5-0.60.80.6-0.20.00.1-2.90.7-2.01.90.91.01.3-1.1
Pavlov. Cond. change in total contacts0.50.62.7-0.10.4-0.20.20.30.4-0.41.10.2-0.11.01.4-0.5-1.6
Pavlov. Cond. index score0.70.93.90.21.1-0.30.40.60.5-2.01.2-0.81.01.01.10.7-0.9
Pavlov. Cond. latency score0.70.94.4-0.00.9-0.10.10.30.2-2.11.0-1.11.30.80.91.1-0.7
Pavlov. Cond. lever contacts0.60.71.90.30.9-0.60.40.60.3-1.41.4-0.30.51.01.30.4-1.2
Pavlov. Cond. magazine entry number0.91.16.00.7-0.4-0.70.40.20.12.4-0.31.6-1.7-0.5-0.7-1.20.7
Pavlov. Cond. intertrial magazine entries0.70.82.50.70.4-0.41.00.90.41.60.11.0-1.60.2-0.1-1.60.1
Pavlov. Cond. lever-magazine prob. diff.0.70.92.90.41.1-0.60.50.70.7-1.71.3-0.40.61.11.20.4-1.1
Pavlov. Cond. response bias0.91.12.90.31.2-0.40.50.70.8-1.51.4-0.40.51.41.60.1-1.7
Pavlov. Cond. lever latency2.33.28.12.10.8-2.41.51.51.61.81.42.8-2.51.01.0-1.8-0.9
Pavlov. Cond. magazine entry latency0.91.14.6-1.00.51.4-0.3-0.3-0.4-1.9-0.2-2.11.70.40.50.8-0.6
Pavlov. Cond. change in total contacts0.60.93.4-1.10.41.3-0.2-0.2-0.3-1.70.2-1.81.30.50.60.4-0.7
Pavlov. Cond. index score1.11.55.7-1.50.11.9-0.6-0.6-0.7-1.9-0.5-2.41.80.10.10.9-0.2
Pavlov. Cond. latency score0.81.14.2-1.30.11.7-0.5-0.5-0.6-1.6-0.4-2.01.60.20.20.7-0.4
Pavlov. Cond. lever contacts2.63.69.8-2.3-0.72.6-1.5-1.5-1.7-2.1-1.4-3.12.7-1.1-1.22.01.1
Pavlov. Cond. magazine entry number0.70.93.21.1-0.3-1.40.30.20.41.50.01.8-1.3-0.4-0.5-0.40.7
Pavlov. Cond. intertrial magazine entries0.61.02.4-0.3-1.30.2-1.0-0.7-0.90.8-1.00.3-0.0-1.5-1.50.61.6
Pavlov. Cond. lever-magazine prob. diff.1.11.55.6-1.50.11.8-0.6-0.6-0.7-2.0-0.4-2.41.80.10.10.9-0.3
Pavlov. Cond. response bias2.43.310.2-2.3-0.42.7-1.3-1.2-1.4-2.3-1.1-3.22.6-0.8-0.81.70.7
Time in closed arm before self-admin1.31.63.81.72.0-1.41.81.81.5-0.51.50.3-0.61.20.9-0.5-0.3
Time in closed arm after self-admin1.92.04.01.31.8-1.11.61.61.2-0.51.60.2-0.52.02.0-0.9-1.9
Time in open arm before self-admin0.80.91.4-0.7-0.90.9-1.2-0.8-0.9-0.2-1.1-0.91.0-1.0-1.01.20.9
Time in open arm after self-admin1.92.14.4-1.4-2.11.4-1.6-1.4-1.11.9-1.70.7-0.5-1.7-1.7-0.51.3
Bone: periosteal estimation0.51.01.7-1.3-1.31.3-1.1-1.0-0.90.6-1.2-0.50.4-1.1-1.20.31.1
Bone: periosteal perimeter0.91.62.3-1.4-1.51.4-1.5-1.5-1.1-0.2-1.5-0.91.0-1.4-1.41.01.4
Bone: post-yield work0.30.41.10.2-0.3-0.60.10.10.00.90.60.9-0.90.50.8-0.8-1.1
Progressive ratio test 1 active lever presses0.10.10.70.30.4-0.10.30.20.4-0.30.1-0.20.2-0.2-0.40.20.8
Progressive ratio test 1 breakpoint0.10.10.50.30.5-0.20.30.20.4-0.30.1-0.20.2-0.2-0.30.20.7
Progressive ratio test 1 inactive lever presses0.10.20.40.10.5-0.10.20.30.3-0.50.5-0.40.20.60.6-0.0-0.6
Progressive ratio test 2 active lever presses0.10.10.20.10.40.10.40.20.50.1-0.0-0.10.0-0.1-0.3-0.20.5
Progressive ratio test 2 breakpoint0.10.10.3-0.10.20.30.30.00.30.1-0.2-0.20.1-0.2-0.4-0.10.6
Progressive ratio test 2 inactive lever presses0.10.10.3-0.3-0.30.4-0.2-0.4-0.20.2-0.2-0.10.1-0.5-0.4-0.00.5
Incentive Sensitization - Responses0.10.10.50.1-0.10.10.1-0.10.10.7-0.30.3-0.2-0.1-0.3-0.20.3
Incentive Sensitization - Breakpoint0.00.00.40.0-0.00.20.1-0.10.10.6-0.30.1-0.1-0.0-0.2-0.10.2
Sum of active levers in priming session hrs 5-61.01.02.50.60.1-0.70.40.60.71.50.61.6-1.30.80.9-1.3-1.2
Progressive ratio0.10.10.4-0.00.4-0.10.60.50.10.30.60.1-0.20.20.1-0.3-0.0
Food seeking constrained by brief footshock0.10.10.80.10.1-0.10.1-0.1-0.0-0.90.1-0.30.20.10.20.2-0.2
Seeking ratio, punishment vs. effort0.10.11.40.30.1-0.1-0.1-0.20.2-1.2-0.2-0.30.30.10.20.3-0.1
Retroperitoneal fat weight2.510.718.5-4.2-2.74.3-3.6-3.5-3.6-1.7-3.2-4.14.0-2.4-2.13.21.5
Reaction time number correct1.12.25.4-2.0-2.31.9-1.8-1.5-1.81.8-1.5-0.1-0.0-1.3-1.1-0.20.5
Reaction time mean minus median0.51.21.9-1.4-0.91.3-1.1-0.9-0.7-1.1-1.0-1.11.0-1.3-1.40.91.3
Reaction time mean minus median AUC1.23.04.9-2.2-1.72.2-2.0-1.8-1.7-0.7-1.9-1.71.6-1.7-1.71.41.3
Reaction time num false alarms0.10.21.30.10.1-0.1-0.1-0.2-0.4-0.10.2-0.30.30.50.80.2-1.1
Reaction time num false alarms AUC0.20.31.30.30.5-0.30.30.20.1-0.10.5-0.20.10.70.9-0.1-1.1
Reaction time trials correct on left1.12.25.4-2.0-2.31.9-1.8-1.5-1.81.8-1.5-0.1-0.0-1.3-1.1-0.20.5
Reaction time trials on left1.22.25.3-2.0-2.31.9-1.8-1.5-1.81.8-1.5-0.20.0-1.3-1.1-0.20.5
Reaction time mean0.50.71.90.71.3-0.41.21.21.4-1.10.8-0.1-0.40.70.4-0.6-0.2
Reaction time mean AUC0.20.30.80.30.8-0.10.70.80.9-0.90.3-0.3-0.10.3-0.0-0.30.2
Median of all reaction times1.62.24.61.62.1-1.32.02.02.1-1.01.50.4-0.91.51.2-1.2-0.8
Reaction time omissions0.91.32.8-1.2-0.51.2-1.1-1.0-0.7-1.6-0.8-1.71.7-0.6-0.51.40.5
Reaction time false alarm rate0.60.91.91.11.4-1.01.00.80.8-1.11.0-0.20.21.01.10.2-1.0
Reaction time premature initiation rate1.41.94.50.92.1-0.91.51.41.2-1.71.9-0.70.41.71.7-0.1-1.3
Reaction time premature initiations0.30.51.2-0.10.90.20.50.50.2-0.71.0-0.70.30.91.1-0.3-1.1
Std. dev. reaction times0.81.52.3-1.3-0.61.4-1.0-0.8-0.6-1.4-1.3-1.51.3-1.2-1.51.11.5
Reaction time trials completed1.22.25.3-2.0-2.31.9-1.8-1.5-1.81.8-1.5-0.20.0-1.3-1.1-0.20.5
Reaction time trials AUC1.01.84.3-1.9-2.11.9-1.6-1.3-1.61.7-1.3-0.1-0.1-1.1-0.9-0.40.3
Run reversals in cocaine runway, females0.50.51.6-0.2-0.7-0.2-0.1-0.00.01.10.31.3-1.20.10.4-1.2-0.8
Run reversals in cocaine runway, males1.01.02.31.50.9-1.31.10.61.10.40.51.0-1.01.01.0-0.9-0.9
Latency to leave start box in cocaine runway0.10.10.40.10.7-0.00.60.30.3-0.60.2-0.50.00.40.4-0.2-0.2
Latency to leave start box in cocaine runway, F0.10.20.50.50.5-0.70.70.40.4-0.00.30.1-0.30.30.2-0.1-0.0
Latency to leave start box in cocaine runway, M0.40.41.2-0.80.41.00.1-0.1-0.0-1.00.1-1.10.60.50.6-0.2-0.6
Std. dev. time between licks in bursts1.72.33.6-1.4-1.71.3-1.7-1.5-1.8-0.4-1.6-1.01.1-1.9-1.91.41.8
Total sessions with >9 infusions0.50.63.60.40.3-0.30.1-0.10.4-0.6-0.4-0.60.7-0.8-1.21.21.9
Short access day 1 total inactive lever presses0.91.22.8-1.1-1.70.7-1.5-1.6-1.51.0-1.5-0.30.5-0.9-0.71.00.3
Short access day 10 total inactive lever presses0.41.04.8-1.4-1.10.9-1.1-0.7-1.3-0.20.4-0.10.10.51.2-0.4-2.2
Short access day 1 total infusions0.20.31.20.70.1-0.70.20.00.50.5-0.20.5-0.2-0.5-0.70.41.1
Short access day 10 total infusions0.20.21.00.20.6-0.20.40.30.6-0.50.2-0.50.5-0.1-0.50.61.0
Short access total infusions0.40.54.00.40.2-0.20.20.10.40.1-0.3-0.10.2-0.9-1.40.62.0
Short access day 1 locomotion0.30.41.11.11.0-0.90.70.70.9-0.60.3-0.20.30.1-0.10.60.7
Short access day 10 total locomotion0.91.73.3-0.6-1.80.4-1.5-1.6-1.41.2-1.70.20.3-1.6-1.61.11.4
Short access total locomotion1.21.44.1-0.5-0.60.5-1.1-1.1-0.8-0.9-1.2-1.31.6-1.1-1.32.01.6
One hour access (0.3 mA shock)1.01.24.90.3-0.2-0.10.50.60.52.20.21.7-1.80.00.0-2.0-0.2
Compulsive drug intake0.50.63.2-0.2-0.50.3-0.00.6-0.11.80.20.9-1.2-0.1-0.1-1.3-0.2
One hour access (shock baseline)0.10.10.30.20.5-0.10.3-0.10.4-0.60.0-0.20.20.20.20.00.0
Social response proportion1.21.33.6-0.21.40.50.70.81.2-1.11.3-0.80.51.61.7-0.6-1.9
Social responses2.02.56.01.02.5-0.41.81.82.0-2.11.9-0.60.21.91.7-0.8-1.5
Social time0.10.10.3-0.10.50.40.50.20.50.3-0.1-0.40.10.40.2-0.4-0.1
Soleus weight0.10.20.60.10.60.10.70.80.20.30.5-0.3-0.10.40.2-0.5-0.2
Bone: stiffness0.61.02.5-1.6-1.11.4-1.2-1.1-1.3-0.2-0.8-1.21.0-0.5-0.20.6-0.2
Tibialis anterior weight0.10.20.6-0.40.30.80.30.5-0.00.80.2-0.5-0.00.40.3-0.6-0.5
Time to tail flick, vehicle, before self-admin0.50.61.3-0.5-0.60.4-0.8-0.7-0.70.2-1.1-0.60.7-0.8-0.91.10.9
Time to tail flick, vehicle, after self-admin0.50.72.0-0.3-0.80.5-0.3-0.4-0.51.4-1.10.3-0.3-1.1-1.4-0.01.4
Time to tail flick, test, before self-admin0.20.21.5-0.20.20.2-0.2-0.1-0.1-1.2-0.1-0.80.6-0.0-0.10.70.2
Time to tail flick, test, after self-admin0.60.71.0-0.9-0.71.0-0.8-0.8-0.70.3-1.0-0.70.8-0.9-1.00.81.0
Delta time to tail flick, vehicle, before/after SA0.60.61.2-1.0-1.11.0-0.5-0.7-0.81.0-0.80.2-0.4-0.8-0.8-0.70.4
Delta time to tail flick, test, before/after SA0.20.20.6-0.3-0.30.4-0.1-0.3-0.20.7-0.5-0.10.2-0.5-0.70.30.8
Tibia length1.02.76.1-1.6-1.21.4-1.9-1.8-1.8-1.6-1.2-2.22.5-1.0-0.62.50.5
Ambulatory time before self-admin0.50.81.2-0.9-1.00.9-0.8-0.9-1.00.7-1.0-0.60.5-1.1-1.10.71.0
Ambulatory time after self-admin0.20.30.40.40.6-0.20.60.60.70.60.50.1-0.30.70.6-0.5-0.5
Bone: tissue strength0.30.30.9-0.5-0.80.3-0.8-0.8-0.9-0.2-0.3-0.30.4-0.40.00.4-0.2
Total heroin consumption0.30.41.50.7-0.1-1.00.30.30.20.80.41.2-0.80.20.2-0.3-0.3
Bone: trabecular number0.91.53.3-1.7-1.81.5-1.4-1.2-1.71.6-1.0-0.0-0.0-1.1-0.9-0.30.3
Bone: trabecular spacing0.81.16.50.91.4-0.50.80.40.9-2.5-0.0-1.11.10.50.11.20.4
Bone: trabecular thickness0.60.82.00.40.4-0.40.91.01.01.40.91.1-1.30.3-0.1-1.40.2
Bone: trabecular tissue density3.85.612.02.11.1-2.62.12.12.11.92.43.5-3.31.82.0-3.1-2.1
Water consumed over 24 hours0.30.41.30.50.8-0.30.71.10.80.00.90.1-0.40.50.3-0.6-0.1
Number of responses in last shaping day0.40.40.90.60.8-0.50.40.30.4-0.50.5-0.50.61.00.90.7-0.8