Hub : Genes

Itpka

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA isoform ratio NM_031045.2 0.1 0.06 3.4e-05 0.07 0.08 0.07 0.07 1.2e-04 6.8e-05 1.4e-04 1.3e-04
2 BLA isoform ratio XM_039105917.1 0.1 0.06 2.0e-05 0.06 0.08 0.07 0.07 5.4e-04 4.5e-05 8.5e-05 1.0e-04
3 PL mRNA stability Itpka 0.07 0.03 7.2e-09 0.06 0.08 0.08 0.08 1.1e-07 3.4e-09 7.1e-09 6.3e-09
4 IL alternative TSS NM_031045.2 0.26 0.15 6.9e-03 0.02 0.03 -0 0.03 1.1e-01 5.7e-02 3.3e-01 6.7e-02
5 NAcc mRNA stability Itpka 0.04 0.02 6.0e-06 0.04 0.04 0.04 0.04 2.4e-05 9.6e-06 3.5e-05 1.5e-05
6 BLA alternative TSS NM_031045.2 0.11 0.06 6.5e-06 0.06 0.09 0.09 0.08 3.7e-04 1.4e-05 1.6e-05 3.5e-05
7 BLA alternative TSS XM_039105917.1 0.11 0.06 8.2e-06 0.06 0.09 0.08 0.08 5.3e-04 2.3e-05 3.4e-05 6.8e-05
8 IL alternative TSS XM_039105917.1 0.27 0.15 5.2e-03 0.01 0.04 0 0.04 1.4e-01 4.8e-02 3.0e-01 5.0e-02
9 BLA mRNA stability Itpka 0.05 0.03 8.7e-03 0.01 0 -0 0 1.5e-01 2.2e-01 3.8e-01 2.7e-01
10 PL isoform ratio XM_039105917.1 0.07 0.04 1.0e-10 0.08 0.1 0.08 0.09 2.2e-09 1.4e-10 3.8e-09 3.1e-10
11 IL mRNA stability Itpka 0.14 0.09 6.6e-03 0.02 0.02 0.01 0.01 9.2e-02 1.0e-01 2.3e-01 2.3e-01
12 PL isoform ratio NM_031045.2 0.07 0.04 4.9e-10 0.08 0.09 0.07 0.08 3.9e-09 6.6e-10 1.5e-08 2.2e-09
13 PL alternative TSS NM_031045.2 0.07 0.04 6.2e-10 0.09 0.09 0.09 0.09 1.7e-10 3.8e-10 4.0e-10 2.0e-10
14 PL alternative TSS XM_039105917.1 0.08 0.04 1.3e-10 0.1 0.1 0.08 0.1 7.1e-11 1.2e-10 2.9e-09 7.2e-11
15 Brain mRNA stability Itpka 0.03 0.02 7.1e-04 0.04 0.03 0.03 0.03 1.7e-04 6.5e-04 6.4e-04 1.9e-03
16 OFC mRNA stability Itpka 0.21 0.12 9.7e-04 0.15 0.13 0.14 0.15 1.7e-04 6.2e-04 2.7e-04 2.1e-04
17 NAcc isoform ratio XM_039105917.1 0.03 0.02 4.7e-04 0.03 0.03 0.02 0.03 6.0e-04 3.6e-04 2.4e-03 6.1e-04
18 NAcc alternative TSS XM_039105917.1 0.03 0.02 1.0e-04 0.03 0.03 0.03 0.03 1.5e-04 1.1e-04 4.3e-04 2.4e-04
19 NAcc isoform ratio NM_031045.2 0.02 0.01 4.2e-03 0.02 0.02 0.01 0.01 4.3e-03 3.6e-03 1.5e-02 6.1e-03
20 Liver gene expression Itpka 0.03 0.02 5.7e-03 0.01 0.01 0.01 0.01 3.7e-02 4.7e-02 1.4e-02 6.4e-02
21 Eye gene expression Itpka 0.47 0.19 3.8e-03 0 0.06 0.02 0 3.0e-01 5.0e-02 1.4e-01 2.6e-01
22 NAcc alternative TSS NM_031045.2 0.02 0.02 1.1e-03 0.02 0.02 0.02 0.02 2.2e-03 1.2e-03 1.3e-03 4.1e-03
23 PL gene expression Itpka 0.04 0.02 9.3e-04 0.01 0.03 0.02 0.02 2.5e-02 3.6e-04 1.3e-03 2.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Bone: apparent density0.91.42.4-1.51.5-1.5-1.0-1.5-1.51.41.01.21.11.2-1.01.2-1.21.11.11.21.2-1.21.1-0.2-1.10.4
Area under the delay curve3.84.17.0-2.02.0-1.7-2.5-1.9-2.12.12.61.81.51.7-1.61.8-1.82.32.32.12.3-2.12.1-0.8-2.32.0
BMI with tail3.912.717.6-3.63.6-4.1-1.4-3.9-3.73.61.63.94.03.9-4.03.9-3.94.24.23.93.7-3.92.3-2.7-3.62.4
BMI without tail4.69.615.0-3.83.8-3.9-2.0-3.8-3.63.62.03.23.03.4-3.03.4-3.43.03.03.23.1-3.12.9-1.0-2.81.1
Body weight4.016.923.6-4.14.2-4.8-1.1-4.6-4.24.21.34.74.94.6-4.84.6-4.64.24.24.54.3-4.53.0-3.4-4.12.7
Weight adjusted by age1.01.21.9-0.70.8-0.8-0.2-1.0-0.90.90.31.31.31.1-1.31.3-1.31.01.01.21.2-1.21.2-1.4-1.21.4
Bone surface0.40.71.5-1.01.0-1.2-0.2-1.0-0.90.90.20.91.00.9-0.90.9-0.90.90.90.90.8-0.90.2-0.4-0.70.1
Bone volume0.61.02.0-1.21.2-1.4-0.4-1.2-1.11.10.41.11.11.1-1.01.1-1.11.31.31.11.0-1.00.3-0.4-0.90.2
Breakpoint value in progressive ratio session0.10.10.7-0.20.1-0.2-0.1-0.0-0.10.00.1-0.2-0.3-0.40.3-0.10.10.10.1-0.2-0.20.2-0.80.60.3-0.8
Number of licking bursts0.30.41.6-0.0-0.00.1-0.50.30.1-0.10.4-0.6-0.8-0.60.8-0.60.6-0.5-0.5-0.6-0.50.6-1.01.30.6-1.1
Context. condit. distance diff. score1.01.22.9-1.51.5-1.70.1-1.5-1.31.3-0.11.31.21.2-1.21.2-1.21.01.00.90.8-0.90.7-0.2-0.6-0.5
Locomotion velocity, session 11.41.53.01.2-1.21.7-0.41.41.2-1.10.4-1.4-1.6-1.41.6-1.41.4-1.5-1.5-1.3-1.01.2-0.21.11.0-0.2
Locomotion distance, session 10.60.72.00.6-0.71.1-0.40.80.6-0.60.4-0.9-1.2-0.91.1-0.80.8-1.4-1.4-0.9-0.70.90.41.00.7-0.3
Locomotion velocity, session 22.22.65.5-1.91.8-1.4-2.3-1.7-1.91.92.31.51.01.5-1.01.5-1.51.21.21.51.8-1.52.2-0.1-1.71.2
Locomotion distance, session 20.30.41.50.0-0.10.4-0.50.20.2-0.20.4-0.5-0.8-0.50.9-0.50.5-1.2-1.2-0.6-0.40.60.41.10.5-0.7
Locomotion velocity, session 30.50.62.7-0.80.7-0.5-1.6-0.5-0.80.81.60.50.20.6-0.20.5-0.51.01.00.60.8-0.60.40.3-0.80.6
Locomotion distance, session 30.20.31.7-0.50.4-0.3-0.7-0.1-0.30.30.6-0.1-0.5-0.10.5-0.10.10.30.3-0.3-0.20.3-0.71.30.4-1.1
Stereotopy head waving bouts, day 33.74.45.8-1.71.8-1.9-1.0-2.0-1.91.91.22.32.32.2-2.32.3-2.32.42.42.32.3-2.31.8-2.0-2.42.2
Stereotopy head waving duration, day 35.86.99.0-2.42.4-2.4-1.9-2.6-2.62.62.12.82.72.7-2.72.7-2.72.82.82.92.9-2.92.6-2.1-3.02.8
Locomotion velocity, session 70.40.40.8-0.90.9-0.8-0.6-0.8-0.80.80.50.60.40.7-0.40.7-0.70.60.60.40.5-0.40.70.3-0.4-0.3
Locomotion distance, session 70.20.31.8-0.0-0.00.00.60.10.2-0.2-0.7-0.4-0.4-0.40.4-0.40.4-0.6-0.6-0.6-0.60.7-0.30.90.8-1.3
Stereotopy head waving bouts, day 70.10.10.80.4-0.30.10.50.20.2-0.2-0.40.20.40.2-0.40.1-0.10.40.40.20.1-0.3-0.3-0.9-0.20.6
Stereotopy head waving duration, day 70.20.20.70.6-0.60.40.40.50.4-0.4-0.4-0.10.2-0.0-0.2-0.10.10.50.50.1-0.0-0.1-0.7-0.9-0.20.8
Locomotion velocity, session 83.64.36.1-2.42.4-2.2-1.9-2.4-2.42.41.92.31.82.2-1.82.2-2.21.81.82.12.2-2.02.5-0.6-2.01.2
Locomotion distance, session 80.40.61.6-1.31.2-1.2-0.3-1.2-1.01.00.20.80.50.7-0.50.8-0.80.00.00.50.5-0.41.10.5-0.2-0.8
Degree of sensitization distance1.01.13.51.2-1.20.91.91.01.2-1.2-1.8-0.8-0.4-0.90.4-0.80.8-1.1-1.1-0.8-1.00.8-0.6-0.50.9-0.4
Degree of sensitization stereotypy0.70.81.61.2-1.20.91.21.11.1-1.1-1.1-0.8-0.5-0.70.5-0.80.8-0.4-0.4-0.8-0.90.7-1.3-0.20.8-0.3
Conditioned locomotion2.02.33.7-1.81.8-1.9-0.6-1.9-1.71.70.61.71.71.7-1.61.7-1.71.51.51.61.5-1.51.4-0.8-1.40.5
Cocaine response after cond. corrected0.80.94.2-0.0-0.10.4-1.40.50.1-0.21.2-1.0-1.4-1.01.4-1.01.0-0.2-0.2-0.8-0.70.8-1.12.10.8-1.3
Cocaine response after cond. not corrected1.01.14.8-0.0-0.10.5-1.60.60.2-0.21.4-1.1-1.6-1.11.6-1.11.1-0.5-0.5-0.9-0.70.9-0.82.20.8-1.2
Cocaine response before conditioning0.10.10.80.2-0.20.4-0.00.10.1-0.10.10.0-0.00.00.00.0-0.0-0.6-0.6-0.00.1-0.00.9-0.3-0.10.6
Saline control response1.52.06.1-0.60.7-1.10.9-1.1-0.80.8-0.71.62.01.6-2.01.6-1.61.11.11.51.3-1.51.2-2.5-1.51.7
Bone: connectivity density0.20.40.8-0.40.4-0.60.1-0.6-0.50.5-0.00.70.80.7-0.80.7-0.70.40.40.70.6-0.70.7-0.9-0.70.7
Bone: cortical apparent density2.33.06.31.9-1.91.61.71.91.9-1.9-1.8-1.8-1.5-1.81.5-1.81.8-1.2-1.2-1.8-1.91.8-2.50.71.9-1.5
Bone: cortical area1.72.63.7-1.61.6-1.8-0.7-1.7-1.61.60.81.81.81.8-1.81.8-1.81.91.91.71.7-1.71.0-1.2-1.61.1
Bone: cortical porosity0.70.84.8-1.00.9-0.3-2.2-0.6-0.90.92.10.1-0.6-0.10.60.1-0.1-0.2-0.20.10.4-0.11.21.5-0.3-0.2
Bone: cortical porosity1.01.14.1-1.31.3-0.8-2.0-1.1-1.31.32.00.80.30.7-0.30.8-0.80.50.50.81.0-0.81.50.6-0.90.5
Bone: cortical thickness1.52.43.0-1.61.6-1.7-1.0-1.7-1.71.71.11.71.61.7-1.61.7-1.71.71.71.71.6-1.61.3-0.9-1.61.1
Bone: cortical thickness0.20.31.3-0.50.4-0.5-0.8-0.2-0.30.30.7-0.2-0.4-0.30.5-0.20.20.30.3-0.1-0.10.1-0.91.10.3-1.0
Bone: cortical tissue density2.22.96.21.8-1.81.51.71.91.9-1.9-1.7-1.8-1.4-1.81.4-1.81.8-1.1-1.1-1.7-1.91.7-2.50.71.8-1.5
Condit. Reinf. active minus inactive responses2.12.47.02.2-2.11.72.61.82.0-2.0-2.6-1.2-0.5-1.20.5-1.11.1-1.1-1.1-1.2-1.51.2-1.5-1.01.2-0.1
Condit. Reinf. active-inactive response ratio0.30.31.50.5-0.50.11.20.20.4-0.4-1.10.20.60.2-0.60.3-0.30.40.40.2-0.0-0.2-0.4-1.2-0.10.5
Condit. Reinf. active responses4.65.713.23.2-3.12.63.62.73.0-3.0-3.6-2.1-1.3-2.01.2-2.02.0-2.0-2.0-2.1-2.42.1-2.3-0.82.1-0.7
Condit. Reinf. inactive responses4.04.77.22.6-2.52.32.62.42.6-2.5-2.7-2.1-1.6-2.11.6-2.02.0-2.1-2.1-2.2-2.42.2-2.00.42.2-1.3
Incentive salience index mean3.64.48.92.9-2.82.53.02.52.7-2.7-2.9-1.8-1.2-1.81.1-1.71.7-2.0-2.0-1.9-2.11.8-1.8-0.71.8-0.3
Condit. Reinf. lever presses2.53.36.42.5-2.52.32.52.12.4-2.3-2.4-1.6-1.1-1.51.0-1.51.5-2.0-2.0-1.6-1.71.6-1.1-0.71.5-0.0
Condit. Reinf. active minus inactive responses0.40.54.30.5-0.5-0.12.10.10.5-0.5-2.00.10.70.1-0.70.1-0.1-0.1-0.10.0-0.3-0.0-0.5-1.30.2-0.0
Condit. Reinf. active-inactive response ratio0.30.32.60.4-0.4-0.01.60.20.5-0.5-1.60.00.5-0.0-0.40.0-0.0-0.1-0.1-0.1-0.30.1-0.5-0.90.3-0.2
Condit. Reinf. active responses0.60.85.60.6-0.5-0.22.40.10.5-0.5-2.30.41.00.3-1.00.3-0.30.20.20.2-0.1-0.2-0.6-1.80.00.2
Condit. Reinf. inactive responses0.50.63.60.6-0.5-0.11.60.10.4-0.4-1.50.51.00.5-1.00.5-0.50.50.50.50.2-0.5-0.4-1.9-0.40.9
Condit. Reinf. lever presses0.60.84.90.9-0.80.21.70.30.6-0.6-1.60.41.00.4-1.00.4-0.40.50.50.40.1-0.5-0.4-2.2-0.41.3
Condit. Reinf. lever reinforcers received0.71.06.80.9-0.80.12.60.30.8-0.8-2.50.20.90.2-1.00.2-0.20.00.00.1-0.3-0.1-0.6-2.00.10.4
Conditioned reinforcement - actives0.10.10.80.3-0.20.30.30.00.1-0.1-0.20.20.30.2-0.40.1-0.1-0.1-0.10.20.2-0.20.8-0.9-0.40.9
Conditioned reinforcement - inactives0.10.10.5-0.20.2-0.30.2-0.2-0.10.1-0.30.1-0.0-0.20.1-0.20.2-0.0-0.0-0.1-0.20.2-0.10.40.3-0.7
Conditioned locomotion0.30.42.90.5-0.40.50.10.10.2-0.10.00.40.50.4-0.60.2-0.20.20.20.40.5-0.50.9-1.4-0.71.7
Patch foraging indifference point 0 sec2.64.211.4-0.60.8-1.1-0.1-1.3-1.21.20.42.32.52.4-2.62.0-2.02.32.32.32.1-2.41.8-3.3-2.53.4
Patch foraging indifference point AUC2.93.34.72.0-2.02.11.22.12.0-2.0-1.3-2.2-1.8-1.91.8-1.81.8-1.7-1.7-2.0-2.01.9-1.91.01.9-1.2
Delay disc. indifference point, 0s delay0.40.53.30.3-0.20.3-0.40.1-0.10.10.60.20.50.4-0.60.5-0.50.80.80.60.6-0.70.7-1.2-0.91.8
Delay disc. indifference point, 16s delay1.51.55.5-1.11.1-0.8-2.3-0.9-1.31.32.30.80.50.7-0.50.8-0.81.51.51.11.3-1.11.00.1-1.31.2
Delay disc. indifference point, 2s delay0.30.40.7-0.40.4-0.60.4-0.6-0.40.4-0.30.70.90.6-0.90.7-0.70.80.80.60.5-0.60.5-0.8-0.50.5
Delay disc. indifference point, 24s delay0.30.30.80.6-0.60.9-0.60.70.5-0.50.6-0.6-0.7-0.70.7-0.60.6-0.4-0.4-0.4-0.30.40.10.40.20.4
Delay disc. indifference point, 4s delay1.81.93.9-1.41.4-1.1-1.8-1.3-1.51.51.81.21.01.2-1.01.2-1.21.21.21.41.5-1.42.0-0.5-1.51.4
Delay disc. indifference point, 8s delay7.37.611.1-2.62.6-2.5-3.0-2.6-2.92.93.22.62.42.4-2.42.6-2.63.33.32.93.1-3.02.4-1.4-3.12.7
Indifference point function ln k4.05.58.8-2.92.9-3.0-1.8-2.8-2.82.81.82.62.22.4-2.22.5-2.52.32.32.42.4-2.32.0-0.7-2.20.8
Indifference point function log k4.05.58.8-2.92.9-3.0-1.8-2.8-2.82.81.82.62.22.4-2.22.5-2.52.32.32.42.4-2.32.0-0.7-2.20.8
Patch foraging total patch changes 0 sec2.13.49.7-0.50.6-0.90.0-1.1-1.01.00.32.02.32.1-2.41.8-1.82.22.22.11.9-2.11.4-3.1-2.23.1
Patch foraging total patch changes 12 sec0.50.72.61.4-1.31.01.60.91.1-1.0-1.4-0.30.3-0.0-0.3-0.10.1-0.2-0.2-0.2-0.40.1-0.4-1.60.01.1
Patch foraging total patch changes 18 sec0.70.92.21.5-1.41.31.31.31.3-1.3-1.2-1.0-0.6-0.60.5-0.80.8-0.6-0.6-0.8-0.90.8-0.7-0.50.70.2
Patch foraging total patch changes 24 sec1.31.63.6-0.70.7-0.9-0.3-1.0-0.90.90.51.21.51.5-1.51.3-1.31.51.51.41.4-1.51.2-1.8-1.51.9
Patch foraging total patch changes 6 sec0.30.41.31.1-1.00.81.00.80.8-0.8-0.9-0.10.1-0.2-0.2-0.20.20.20.2-0.2-0.30.1-0.5-1.20.00.9
Patch foraging time to switch 0 sec0.91.33.11.8-1.71.51.81.41.6-1.5-1.7-0.8-0.5-1.00.4-0.90.9-0.9-0.9-0.9-1.00.8-0.9-0.90.70.4
Patch foraging water rate 0 sec0.50.81.8-1.11.1-1.3-0.4-1.1-1.01.00.30.90.91.0-0.91.0-1.01.21.20.90.8-0.80.1-0.1-0.6-0.2
Patch foraging water rate 12 sec0.30.53.2-0.90.8-0.8-0.7-0.5-0.60.60.5-0.1-0.4-0.20.5-0.10.10.10.1-0.2-0.20.3-0.71.70.5-1.8
Patch foraging water rate 18 sec1.31.73.8-1.91.8-1.6-2.0-1.5-1.71.71.91.10.61.1-0.61.0-1.01.31.31.11.2-1.00.80.8-0.9-0.2
Patch foraging water rate 24 sec0.20.31.7-0.40.4-0.80.3-0.3-0.30.2-0.50.20.20.1-0.20.2-0.20.80.80.0-0.20.0-1.30.40.3-1.2
Patch foraging water rate 6 sec1.11.65.40.5-0.60.50.50.90.8-0.8-0.7-1.3-1.4-1.31.4-1.31.3-1.0-1.0-1.4-1.41.4-1.91.91.6-2.3
Seeking ratio, delayed vs. immediate footshock0.20.31.90.0-0.0-0.41.3-0.10.2-0.2-1.40.00.3-0.1-0.30.2-0.2-0.3-0.3-0.2-0.30.2-0.6-0.20.4-0.9
Distance traveled before self-admin0.10.10.3-0.20.2-0.30.1-0.3-0.20.2-0.00.20.50.4-0.50.4-0.40.30.30.40.4-0.40.4-0.6-0.40.5
Distance traveled after self-admin0.10.20.80.2-0.2-0.00.50.30.3-0.3-0.6-0.3-0.2-0.40.2-0.30.3-0.2-0.2-0.3-0.50.4-0.90.30.5-0.8
Extensor digitorum longus weight0.41.41.9-1.41.4-1.3-1.2-1.3-1.41.41.21.21.01.3-1.01.3-1.31.31.31.21.2-1.20.7-0.3-1.20.6
Bone: elastic displacement0.10.10.40.1-0.00.1-0.30.0-0.10.10.40.20.10.1-0.20.2-0.20.40.40.20.3-0.20.1-0.3-0.30.6
Bone: elastic work0.60.71.8-0.20.3-0.50.1-0.5-0.50.50.00.91.10.9-1.10.9-0.91.21.20.90.8-1.00.1-1.3-0.91.2
Bone: endosteal estimation0.00.10.5-0.40.3-0.4-0.1-0.2-0.20.20.0-0.0-0.10.00.1-0.00.00.10.1-0.0-0.10.1-0.30.50.2-0.7
Bone: endosteal perimeter0.00.00.1-0.0-0.0-0.00.10.00.0-0.0-0.1-0.1-0.1-0.10.1-0.10.10.00.0-0.1-0.10.1-0.30.20.2-0.3
Epididymis fat weight0.51.31.9-0.90.9-1.1-0.1-1.1-1.01.00.21.21.41.3-1.41.4-1.41.31.31.21.1-1.21.0-1.2-1.21.0
Delta time in closed arm before/after self-admin0.30.31.00.4-0.40.30.90.30.5-0.5-1.0-0.4-0.3-0.40.3-0.30.3-0.9-0.9-0.5-0.60.6-0.10.20.6-0.7
Delta time in open arm before/after self-admin0.90.92.5-1.41.4-1.6-0.4-1.3-1.21.20.30.80.70.8-0.60.9-0.91.11.10.70.6-0.60.10.5-0.3-0.9
Diff in mean of infusions in LGA sessions0.40.51.90.8-0.80.61.40.70.8-0.8-1.4-0.4-0.2-0.50.2-0.20.2-0.8-0.8-0.5-0.70.5-0.6-0.40.6-0.3
Delay discount exponential model param2.72.95.71.7-1.71.42.31.61.9-1.9-2.4-1.4-1.2-1.31.2-1.51.5-1.9-1.9-1.7-1.91.7-1.90.51.9-1.6
Extinction: sum of active levers before priming0.40.40.80.6-0.60.8-0.40.70.5-0.50.3-0.7-0.8-0.90.8-0.70.7-0.6-0.6-0.6-0.50.6-0.50.60.4-0.1
Active lever presses in extinction session 60.40.31.4-0.70.7-0.4-1.2-0.6-0.70.71.20.40.10.2-0.10.4-0.40.10.10.40.6-0.40.90.4-0.50.3
Bone: final force0.30.50.9-0.60.6-0.90.6-0.7-0.50.5-0.60.81.00.8-0.90.8-0.80.90.90.60.4-0.6-0.1-0.6-0.4-0.1
Bone: final moment0.20.40.8-0.50.5-0.80.5-0.6-0.50.5-0.50.70.90.7-0.80.7-0.70.90.90.50.4-0.5-0.2-0.5-0.3-0.1
Food consumed during 24 hour testing period0.20.21.2-0.30.3-0.1-0.5-0.1-0.10.10.4-0.3-0.6-0.30.6-0.30.3-0.7-0.7-0.4-0.30.4-0.11.10.4-0.9
Glucose0.40.71.5-1.21.1-1.2-0.4-1.1-1.01.00.30.90.80.9-0.70.9-0.90.80.80.70.7-0.70.40.1-0.5-0.4
Heart weight3.95.58.7-2.32.4-2.80.0-2.7-2.32.30.12.72.92.9-2.92.8-2.81.91.92.52.3-2.52.3-2.2-2.21.4
Delay discount hyperbolic model param2.93.04.81.7-1.71.52.11.71.9-1.9-2.2-1.6-1.4-1.41.4-1.61.6-1.9-1.9-1.8-1.91.8-2.00.72.0-1.7
Intermittent access intake day 1-15 change0.50.52.0-1.11.0-1.0-1.1-0.7-0.90.81.00.2-0.20.20.2-0.00.00.60.60.10.2-0.1-0.21.40.1-1.2
Intermittent access intake escalation0.50.52.8-0.80.8-0.7-0.7-0.4-0.50.50.5-0.2-0.5-0.10.5-0.40.40.10.1-0.3-0.20.3-0.51.70.5-1.7
Intermittent access intake escalation 21.41.38.1-1.51.4-0.9-2.1-0.8-1.11.01.8-0.2-0.9-0.21.0-0.40.4-0.1-0.1-0.3-0.00.40.02.80.5-2.1
Intermitt. access day 1 inactive lever presses0.40.42.10.2-0.1-0.11.0-0.20.1-0.0-0.90.60.90.6-0.90.4-0.40.10.10.50.4-0.50.8-1.5-0.51.0
Intermitt. access day 15 inactive lever presses0.30.31.10.5-0.50.41.00.40.6-0.6-1.0-0.3-0.2-0.30.2-0.30.3-0.6-0.6-0.5-0.60.5-0.3-0.00.6-0.5
Intermitt. access escalation Index0.30.20.90.6-0.60.30.80.40.5-0.5-0.8-0.10.20.1-0.2-0.10.10.70.7-0.0-0.2-0.0-0.9-0.80.00.3
Intermittent access day 1 total infusions0.40.51.81.1-1.10.81.30.80.9-0.9-1.2-0.30.0-0.4-0.1-0.40.4-0.2-0.2-0.3-0.50.3-0.6-1.00.30.5
Intermittent access day 15 total infusions0.10.10.30.2-0.20.10.50.20.3-0.3-0.5-0.2-0.2-0.30.2-0.40.40.00.0-0.3-0.30.3-0.50.20.4-0.5
Intermittent access terminal intake (last 3 days)0.10.10.8-0.30.3-0.3-0.1-0.2-0.20.20.0-0.1-0.2-0.10.2-0.20.20.20.2-0.2-0.20.2-0.40.70.3-0.9
Intermittent access total infusions0.10.10.40.2-0.20.10.60.10.2-0.2-0.6-0.00.1-0.1-0.1-0.20.2-0.1-0.1-0.1-0.20.1-0.2-0.20.2-0.1
Intermittent access day 1 locomotion0.80.94.20.2-0.1-0.10.5-0.3-0.10.2-0.30.91.20.8-1.30.9-0.90.90.90.90.8-1.00.7-2.1-1.11.9
Intermittent access day 15 total locomotion0.10.10.7-0.20.2-0.40.8-0.3-0.10.1-0.80.20.30.2-0.30.1-0.1-0.2-0.20.0-0.10.0-0.1-0.10.2-0.5
Intermittent access total locomotion0.10.10.50.3-0.30.20.70.20.3-0.3-0.7-0.00.1-0.1-0.1-0.10.1-0.3-0.3-0.1-0.10.10.0-0.50.10.2
Intermittent access standard deviation0.20.20.9-0.70.6-0.6-0.4-0.4-0.50.40.30.1-0.10.20.2-0.20.2-0.1-0.1-0.00.00.1-0.20.90.2-1.0
Left kidney weight3.610.118.4-3.43.5-3.3-2.2-3.6-3.53.52.33.53.13.7-3.13.3-3.32.42.43.33.4-3.24.3-1.7-3.32.3
Right kidney weight5.615.628.9-4.04.1-3.8-2.7-4.3-4.14.22.94.23.94.4-3.94.2-4.23.13.14.24.3-4.15.4-2.6-4.23.5
Cocaine induced anxiety1.01.25.0-1.01.1-0.8-0.6-1.2-1.11.10.61.21.01.1-1.11.2-1.20.20.21.01.2-1.02.2-0.7-1.11.0
Post-drug Anxiety0.70.71.6-1.21.2-1.0-0.9-1.1-1.11.10.90.80.60.9-0.60.8-0.80.50.50.80.9-0.71.20.1-0.70.2
Baseline Anxiety0.10.10.3-0.40.4-0.5-0.2-0.3-0.30.30.20.20.10.2-0.10.1-0.10.50.50.10.1-0.1-0.60.3-0.0-0.5
Tail length0.10.41.1-1.11.0-1.0-0.2-0.9-0.80.80.10.50.40.6-0.30.6-0.6-0.2-0.20.30.3-0.20.70.5-0.1-0.9
Length with tail0.51.83.0-1.51.6-1.7-0.1-1.7-1.41.40.11.71.61.6-1.61.5-1.50.50.51.41.3-1.31.6-1.0-1.20.5
Length without tail0.51.13.8-0.40.4-0.80.5-0.8-0.60.6-0.31.31.51.1-1.51.0-1.00.90.91.21.0-1.20.5-1.9-1.21.5
Times rat made contact with spout0.50.60.9-0.60.6-0.6-0.5-0.7-0.70.70.50.90.80.9-0.80.9-0.90.40.40.90.9-0.90.7-0.8-0.91.0
Lifetime Intake0.10.10.30.5-0.50.50.50.40.5-0.5-0.4-0.3-0.2-0.40.2-0.50.5-0.2-0.2-0.3-0.30.3-0.5-0.20.30.0
Liver weight, left1.93.06.3-2.32.2-2.5-0.9-2.2-2.12.00.91.81.71.8-1.71.7-1.71.71.71.81.7-1.71.2-0.5-1.40.2
Liver weight, right2.13.54.7-2.02.0-1.9-1.5-2.1-2.02.01.62.01.81.9-1.82.0-2.01.61.62.02.1-2.02.2-1.1-2.01.6
Locomotor activity0.10.20.60.4-0.40.6-0.00.40.4-0.40.1-0.4-0.5-0.40.4-0.40.4-0.7-0.7-0.4-0.30.30.20.10.20.1
Locomotor testing distance0.20.30.80.7-0.70.90.10.70.7-0.6-0.1-0.6-0.7-0.80.6-0.60.6-0.7-0.7-0.6-0.50.6-0.20.30.40.0
Locomotor testing rearing1.62.54.01.6-1.71.71.21.71.7-1.7-1.3-1.5-1.5-1.71.5-1.61.6-2.0-2.0-1.7-1.71.7-1.20.81.6-1.1
Locomotion in novel chamber0.91.11.8-0.80.9-1.0-0.5-1.0-1.01.00.61.31.20.9-1.21.2-1.21.31.31.21.1-1.20.5-1.0-1.21.1
Locomotion in novel chamber post-restriction0.70.82.0-1.21.2-1.4-0.3-1.2-1.11.00.30.91.01.0-0.90.9-0.91.11.10.90.8-0.90.3-0.3-0.7-0.0
Fecal boli incidents, locomotor time 10.30.31.00.3-0.30.6-1.00.50.2-0.21.0-0.6-0.8-0.60.8-0.60.6-0.2-0.2-0.4-0.30.4-0.30.80.2-0.0
Change in fecal boli incidents, locomotor task2.32.23.5-1.61.7-1.9-0.2-1.8-1.61.60.21.71.71.8-1.71.8-1.81.31.31.51.4-1.51.3-1.0-1.30.5
Time >=10cm from walls, locomotor time 10.20.20.80.3-0.30.20.40.30.3-0.3-0.5-0.3-0.4-0.40.4-0.50.5-0.3-0.3-0.4-0.50.4-0.90.40.5-0.7
Bouts of movement, locomotor time 12.42.64.11.5-1.61.9-0.21.81.5-1.50.1-1.9-2.0-1.92.0-2.02.0-2.0-2.0-1.6-1.51.6-1.41.41.4-0.7
Total resting periods, locomotor time 12.93.24.71.8-1.92.10.42.01.8-1.8-0.4-2.0-2.1-1.92.0-2.02.0-2.2-2.2-1.8-1.71.8-1.51.21.6-0.8
Rest time, locomotor task time 10.10.10.20.3-0.30.20.50.20.2-0.2-0.40.00.10.2-0.10.0-0.0-0.4-0.4-0.1-0.10.00.0-0.40.00.2
Distance moved, locomotor task time 10.20.20.80.7-0.70.60.40.60.6-0.6-0.4-0.5-0.3-0.60.3-0.40.40.20.2-0.4-0.40.3-0.9-0.10.30.0
Vertical activity count, locomotor time 10.10.10.50.1-0.1-0.10.50.10.1-0.2-0.5-0.00.1-0.3-0.1-0.10.10.30.3-0.0-0.10.0-0.7-0.20.1-0.2
Time >=10cm from walls, locomotor time 27.57.913.1-2.32.4-3.00.1-3.0-2.52.50.13.33.63.2-3.63.2-3.22.82.83.12.9-3.12.3-3.2-2.92.4
Bouts of movement, locomotor time 20.10.21.60.4-0.40.10.60.30.4-0.4-0.6-0.10.1-0.1-0.1-0.30.30.20.2-0.1-0.20.0-1.3-0.50.10.0
Total resting periods, locomotor time 20.20.22.00.6-0.50.20.70.50.5-0.5-0.7-0.2-0.1-0.30.1-0.40.40.10.1-0.2-0.40.2-1.4-0.40.3-0.1
Rest time, locomotor task time 23.94.56.71.9-2.02.40.62.22.0-2.0-0.8-2.3-2.5-2.32.5-2.32.3-2.6-2.6-2.3-2.22.3-1.41.92.2-1.6
Distance moved, locomotor task time 21.82.13.6-1.01.0-1.30.1-1.3-1.11.10.11.61.91.6-1.91.6-1.61.81.81.61.5-1.61.2-1.9-1.61.6
Vertical activity count, locomotor time 22.52.75.3-1.11.2-1.80.7-1.6-1.21.2-0.62.02.31.8-2.31.7-1.72.02.01.81.5-1.80.5-2.2-1.61.2
Light reinforcement 11.12.012.91.3-1.10.42.60.30.8-0.7-2.31.01.70.9-1.80.9-0.90.30.30.80.4-0.90.2-3.6-0.92.4
Light reinforcement 21.31.72.91.7-1.71.61.41.51.6-1.6-1.4-1.1-1.0-1.40.9-1.11.1-1.6-1.6-1.2-1.31.2-1.2-0.11.1-0.3
Bone: marrow area0.00.10.3-0.40.4-0.5-0.2-0.3-0.30.30.10.10.00.1-0.00.1-0.10.20.20.10.0-0.0-0.20.40.1-0.6
Bone: maximum diameter0.50.91.6-0.80.9-1.20.0-1.0-0.90.90.01.11.21.1-1.21.1-1.11.21.21.00.9-1.00.2-0.9-0.90.5
Bone: maximum force1.42.43.6-1.41.5-1.7-0.1-1.6-1.51.50.21.81.91.8-1.91.8-1.81.71.71.61.5-1.61.2-1.4-1.51.0
Bone: maximum moment1.22.03.0-1.31.4-1.6-0.2-1.5-1.41.40.31.61.71.7-1.71.7-1.71.61.61.51.4-1.51.1-1.3-1.41.0
Mean time between licks in bursts0.40.61.90.2-0.20.6-0.80.50.3-0.30.7-0.8-1.1-0.81.1-0.80.8-0.8-0.8-0.8-0.60.8-0.11.40.7-0.7
Mean num. licks in bursts0.70.82.7-0.20.3-0.50.5-0.6-0.40.5-0.31.01.21.0-1.31.0-1.00.60.60.90.9-1.01.1-1.6-1.01.4
Cd content in liver0.30.30.5-0.60.6-0.6-0.5-0.6-0.60.60.50.60.50.6-0.50.6-0.60.70.70.60.6-0.60.3-0.3-0.60.4
Co content in liver0.30.31.9-0.70.6-0.3-1.4-0.4-0.60.61.30.3-0.10.30.10.3-0.30.30.30.30.5-0.30.60.6-0.40.2
Cu content in liver0.60.83.4-0.1-0.00.1-0.40.30.2-0.20.2-0.8-1.1-0.91.1-0.90.9-0.6-0.6-0.9-0.80.9-0.81.81.0-1.8
Fe content in liver4.85.79.12.8-2.82.43.02.72.8-2.8-3.0-2.3-1.7-2.31.7-2.32.3-2.1-2.1-2.4-2.62.3-2.80.32.4-1.6
K content in liver0.40.41.0-1.00.9-0.8-0.9-0.8-0.90.90.90.50.30.4-0.30.5-0.50.30.30.50.6-0.50.60.4-0.5-0.1
Mg content in liver1.21.33.2-1.81.7-1.6-1.5-1.4-1.51.51.31.00.50.8-0.50.8-0.81.01.00.80.9-0.80.50.9-0.6-0.7
Mn content in liver1.31.52.2-1.41.4-1.3-1.1-1.4-1.41.41.11.31.11.2-1.11.3-1.31.01.01.31.3-1.21.5-0.5-1.30.8
Na content in liver2.82.95.61.4-1.41.51.01.51.6-1.6-1.2-1.8-1.8-1.91.8-1.91.9-2.4-2.4-1.9-1.81.9-1.01.51.9-1.8
Rb content in liver6.07.411.1-3.33.3-3.3-2.4-3.2-3.23.22.42.92.42.8-2.42.8-2.83.03.02.72.8-2.72.1-0.5-2.50.9
Se content in liver0.20.20.6-0.70.7-0.7-0.4-0.6-0.70.70.40.50.30.4-0.30.5-0.50.60.60.40.4-0.30.20.3-0.3-0.3
Sr content in liver0.10.10.5-0.10.10.2-0.7-0.1-0.10.10.70.1-0.10.10.1-0.10.1-0.2-0.20.10.2-0.10.70.0-0.30.6
Zn content in liver0.80.81.70.5-0.60.70.30.70.7-0.7-0.4-1.0-1.1-1.01.1-1.01.0-1.3-1.3-1.0-1.01.0-0.51.11.1-1.2
Bone: minimum diameter2.44.55.5-2.12.1-2.0-2.0-2.2-2.22.22.12.21.92.2-1.92.2-2.22.32.32.22.3-2.32.1-1.1-2.31.9
Time in familiar zone, hab. session 11.41.32.20.8-0.91.1-0.11.10.9-1.00.0-1.3-1.5-1.41.5-1.41.4-1.2-1.2-1.2-1.11.2-1.11.31.1-1.0
Time in novel zone, hab. session 11.81.73.1-0.90.9-1.30.3-1.2-1.01.0-0.21.51.81.6-1.81.5-1.51.61.61.41.2-1.40.8-1.6-1.31.1
Total zone transitions, hab. session 10.20.31.10.4-0.40.7-0.30.40.4-0.40.3-0.6-0.7-0.60.7-0.50.5-1.0-1.0-0.5-0.30.50.40.40.30.0
Total locomotion distance, hab. session 10.10.21.00.3-0.30.6-0.30.30.3-0.20.4-0.4-0.5-0.40.5-0.40.4-1.0-1.0-0.3-0.20.30.80.30.10.3
Locomotion velocity, hab. session 10.30.41.60.5-0.50.9-0.20.50.5-0.50.3-0.6-0.7-0.60.7-0.60.6-1.2-1.2-0.5-0.30.50.70.20.30.3
Time in familiar zone, hab. session 20.10.10.80.3-0.30.10.20.30.3-0.3-0.2-0.2-0.1-0.20.1-0.20.20.30.3-0.1-0.20.1-0.9-0.10.2-0.0
Time in novel zone, hab. session 20.80.81.8-0.90.9-0.9-0.5-1.0-0.91.00.51.00.91.1-0.91.0-1.00.70.70.90.9-0.91.3-0.5-0.90.6
Total zone transitions, hab. session 20.20.20.9-0.40.4-0.0-1.0-0.2-0.30.30.9-0.1-0.4-0.20.4-0.10.1-0.7-0.7-0.10.10.10.80.8-0.0-0.1
Total locomotion distance, hab. session 20.00.10.6-0.10.1-0.0-0.1-0.2-0.10.10.10.10.00.1-0.00.1-0.1-0.5-0.50.10.1-0.10.8-0.1-0.10.2
Locomotion velocity, hab. session 20.10.10.50.1-0.10.20.00.00.1-0.10.0-0.1-0.1-0.10.1-0.10.1-0.7-0.7-0.1-0.00.10.6-0.1-0.00.2
Novel to familiar place preference ratio1.11.13.2-0.50.5-0.90.6-0.8-0.60.6-0.51.21.51.2-1.51.2-1.21.21.21.21.0-1.20.6-1.8-1.11.2
Novelty place preference1.11.12.9-0.50.6-0.90.5-0.9-0.70.7-0.41.21.51.2-1.51.2-1.21.21.21.21.0-1.20.7-1.7-1.11.2
Time in novel zone, NPP test1.01.02.7-0.40.5-0.80.6-0.8-0.60.6-0.51.11.41.1-1.41.1-1.11.11.11.10.9-1.10.6-1.6-1.01.1
Total zone transitions, NPP test0.60.83.9-0.40.30.3-1.50.0-0.20.21.4-0.7-1.2-0.71.3-0.60.6-1.3-1.3-0.6-0.30.70.62.00.5-1.0
Total locomotion distance, NPP test0.50.72.9-1.11.0-0.4-1.7-0.8-0.90.91.60.3-0.30.30.30.3-0.3-0.6-0.60.20.5-0.21.71.1-0.3-0.1
Locomotion velocity, NPP test0.50.83.4-1.11.0-0.4-1.8-0.8-0.90.91.80.3-0.30.30.30.3-0.3-0.6-0.60.20.6-0.21.71.2-0.4-0.0
Intraocular pressure0.71.02.21.5-1.51.50.31.51.2-1.3-0.2-1.1-1.0-1.01.0-1.11.1-0.2-0.2-0.9-0.90.8-1.50.10.70.2
Delta distance traveled before/after self-admin0.50.51.00.7-0.70.60.70.70.7-0.7-0.7-0.5-0.6-0.70.6-0.70.7-0.7-0.7-0.7-0.80.7-1.00.40.8-0.7
Delta ambulatory time before/after self-admin0.70.81.51.1-1.10.91.21.01.1-1.1-1.2-0.7-0.6-0.80.6-0.80.8-0.9-0.9-0.8-0.90.8-0.9-0.10.8-0.4
Parametrial fat weight0.10.20.8-0.20.2-0.20.2-0.4-0.20.2-0.10.40.40.3-0.40.3-0.3-0.4-0.40.40.4-0.40.9-0.7-0.40.6
Pavlov. Cond. lever latency0.20.21.2-0.50.5-0.7-0.4-0.4-0.50.40.30.20.20.2-0.20.2-0.21.11.10.30.2-0.3-0.80.3-0.1-0.4
Pavlov. Cond. magazine entry latency0.70.94.81.1-0.90.62.20.40.8-0.8-2.00.30.80.3-0.90.4-0.4-0.6-0.60.1-0.1-0.10.4-2.1-0.11.1
Pavlov. Cond. change in total contacts0.20.21.20.2-0.20.20.90.10.3-0.3-1.0-0.1-0.1-0.10.1-0.00.0-1.1-1.1-0.4-0.40.40.50.00.5-0.5
Pavlov. Cond. index score0.40.61.51.1-1.01.01.20.70.9-0.9-1.1-0.4-0.1-0.30.1-0.30.3-1.1-1.1-0.4-0.50.40.3-0.90.30.6
Pavlov. Cond. latency score0.30.41.20.9-0.80.81.00.50.7-0.7-0.9-0.10.1-0.1-0.1-0.00.0-1.0-1.0-0.2-0.20.10.6-1.10.00.9
Pavlov. Cond. lever contacts0.30.31.50.6-0.60.80.40.50.6-0.5-0.4-0.4-0.3-0.30.3-0.30.3-1.2-1.2-0.4-0.30.40.7-0.20.20.4
Pavlov. Cond. magazine entry number0.40.52.5-0.70.6-0.4-1.5-0.2-0.50.51.4-0.3-0.7-0.30.7-0.40.40.40.4-0.1-0.00.2-0.61.60.2-0.9
Pavlov. Cond. intertrial magazine entries0.80.94.50.5-0.60.40.30.80.7-0.7-0.4-1.1-1.0-1.01.0-1.11.1-0.2-0.2-0.9-1.01.0-2.11.21.1-1.6
Pavlov. Cond. lever-magazine prob. diff.0.40.51.40.9-0.90.91.00.70.8-0.8-0.9-0.4-0.3-0.40.3-0.30.3-1.2-1.2-0.5-0.50.50.4-0.50.40.3
Pavlov. Cond. response bias0.60.72.31.0-1.00.91.50.81.0-1.0-1.5-0.5-0.3-0.50.3-0.40.4-1.4-1.4-0.7-0.80.70.0-0.40.7-0.1
Pavlov. Cond. lever latency1.82.48.50.3-0.51.2-1.51.00.6-0.61.3-1.7-2.3-1.72.3-1.71.7-1.6-1.6-1.6-1.21.6-0.52.91.4-1.7
Pavlov. Cond. magazine entry latency0.91.17.01.2-1.10.42.70.61.0-1.0-2.50.00.70.1-0.80.1-0.1-0.1-0.1-0.1-0.50.1-0.9-1.90.30.3
Pavlov. Cond. change in total contacts0.70.96.70.9-0.80.22.60.40.8-0.8-2.50.10.80.2-0.80.2-0.2-0.1-0.1-0.0-0.40.0-0.6-1.70.20.2
Pavlov. Cond. index score0.91.17.00.7-0.6-0.12.60.10.6-0.6-2.50.51.30.6-1.30.6-0.60.40.40.3-0.1-0.4-0.7-2.2-0.10.5
Pavlov. Cond. latency score0.70.95.80.6-0.5-0.12.40.10.5-0.5-2.30.51.10.5-1.10.5-0.50.30.30.3-0.1-0.3-0.6-1.9-0.10.4
Pavlov. Cond. lever contacts1.21.78.70.3-0.2-0.62.0-0.40.0-0.0-1.81.21.91.2-1.91.2-1.21.21.21.10.7-1.2-0.0-2.9-1.01.6
Pavlov. Cond. magazine entry number0.60.85.5-0.70.6-0.0-2.3-0.2-0.60.62.3-0.3-0.9-0.30.9-0.30.3-0.0-0.0-0.10.30.10.61.6-0.2-0.1
Pavlov. Cond. intertrial magazine entries1.11.54.5-1.41.4-1.1-2.1-1.2-1.41.42.11.00.51.0-0.51.0-1.01.01.01.11.3-1.11.10.3-1.20.8
Pavlov. Cond. lever-magazine prob. diff.0.81.17.00.8-0.7-0.12.60.20.6-0.6-2.50.41.20.5-1.20.5-0.50.30.30.3-0.1-0.3-0.7-2.1-0.00.5
Pavlov. Cond. response bias1.31.78.90.7-0.5-0.42.7-0.10.4-0.4-2.50.91.81.0-1.81.0-1.00.90.90.80.3-0.8-0.5-3.0-0.61.2
Time in closed arm before self-admin1.82.03.41.8-1.81.80.91.81.7-1.7-0.8-1.5-1.4-1.41.4-1.61.6-1.2-1.2-1.4-1.41.3-1.50.31.2-0.3
Time in closed arm after self-admin2.72.75.12.3-2.22.02.12.02.1-2.1-2.1-1.5-1.1-1.31.1-1.51.5-1.5-1.5-1.5-1.71.5-1.5-0.31.4-0.4
Time in open arm before self-admin0.60.61.0-0.70.7-0.8-0.5-0.7-0.80.80.51.00.90.8-0.90.9-0.90.70.70.90.9-0.90.3-0.7-0.90.8
Time in open arm after self-admin2.83.16.6-2.52.5-2.6-1.5-2.2-2.32.21.41.81.41.5-1.31.7-1.72.02.01.61.5-1.50.70.4-1.2-0.5
Bone: periosteal estimation0.61.21.9-1.21.2-1.4-0.6-1.2-1.21.20.61.21.11.2-1.11.2-1.21.41.41.11.1-1.10.5-0.5-1.00.4
Bone: periosteal perimeter1.01.62.1-1.31.3-1.3-1.0-1.3-1.31.41.01.41.21.4-1.21.4-1.41.41.41.41.4-1.31.0-0.7-1.31.0
Bone: post-yield work0.10.20.9-0.60.5-0.2-0.7-0.4-0.40.40.60.0-0.20.10.20.0-0.0-0.5-0.5-0.00.20.00.90.7-0.0-0.3
Progressive ratio test 1 active lever presses0.50.52.31.0-0.90.61.50.70.9-0.9-1.5-0.3-0.0-0.40.0-0.50.5-0.2-0.2-0.4-0.60.4-1.1-0.70.5-0.0
Progressive ratio test 1 breakpoint0.50.51.90.9-0.90.61.40.70.9-0.9-1.3-0.5-0.2-0.50.2-0.60.6-0.4-0.4-0.6-0.70.6-1.0-0.40.6-0.3
Progressive ratio test 1 inactive lever presses0.70.82.61.1-1.10.91.60.91.1-1.1-1.6-0.6-0.3-0.70.3-0.80.8-0.8-0.8-0.8-0.90.8-0.7-0.40.8-0.4
Progressive ratio test 2 active lever presses1.31.43.61.4-1.31.11.91.21.4-1.4-1.9-0.9-0.6-1.00.6-1.01.0-0.9-0.9-1.1-1.31.1-1.3-0.11.2-0.8
Progressive ratio test 2 breakpoint1.21.44.91.5-1.41.12.21.21.4-1.4-2.2-0.8-0.4-0.80.4-0.80.8-0.7-0.7-1.0-1.21.0-1.5-0.51.1-0.6
Progressive ratio test 2 inactive lever presses0.20.21.20.4-0.40.21.10.30.4-0.4-1.1-0.10.0-0.2-0.0-0.20.2-0.3-0.3-0.3-0.40.3-0.3-0.30.4-0.4
Incentive Sensitization - Responses0.00.00.2-0.00.0-0.10.2-0.00.0-0.0-0.3-0.00.0-0.0-0.00.1-0.10.10.1-0.1-0.10.1-0.40.10.2-0.4
Incentive Sensitization - Breakpoint0.00.00.20.1-0.1-0.00.50.10.1-0.1-0.5-0.00.0-0.1-0.00.0-0.00.00.0-0.1-0.20.2-0.50.00.2-0.4
Sum of active levers in priming session hrs 5-60.20.21.2-0.30.2-0.1-0.4-0.0-0.10.10.3-0.2-0.5-0.30.6-0.20.2-0.3-0.3-0.4-0.30.4-0.21.10.4-1.0
Progressive ratio0.30.40.70.6-0.60.60.40.60.6-0.6-0.4-0.8-0.6-0.50.6-0.70.7-0.9-0.9-0.6-0.60.6-0.40.30.6-0.5
Food seeking constrained by brief footshock0.00.00.10.0-0.00.00.1-0.0-0.00.0-0.00.00.10.0-0.10.1-0.10.10.10.10.1-0.10.3-0.2-0.10.3
Seeking ratio, punishment vs. effort0.00.00.20.1-0.10.10.10.10.0-0.0-0.00.20.2-0.0-0.20.2-0.20.40.40.10.1-0.20.0-0.4-0.20.5
Retroperitoneal fat weight2.17.013.1-2.02.1-2.90.8-2.6-2.12.1-0.63.13.63.0-3.63.1-3.12.92.92.92.5-2.91.3-3.3-2.52.0
Reaction time number correct2.02.96.5-2.32.3-2.5-0.8-2.2-2.12.10.81.81.72.0-1.61.7-1.71.71.71.71.6-1.61.2-0.2-1.3-0.2
Reaction time mean minus median0.60.81.4-0.60.7-0.9-0.1-0.8-0.70.70.11.01.10.7-1.11.1-1.10.90.91.00.9-1.10.4-1.2-1.01.0
Reaction time mean minus median AUC2.22.84.3-1.41.5-1.8-0.3-1.7-1.51.50.51.92.01.7-2.02.1-2.11.81.81.91.8-1.91.0-1.7-1.81.5
Reaction time num false alarms0.00.00.30.2-0.10.20.30.10.1-0.1-0.3-0.10.00.3-0.1-0.00.0-0.3-0.3-0.1-0.10.10.5-0.20.10.1
Reaction time num false alarms AUC0.20.30.60.6-0.60.60.80.50.6-0.6-0.8-0.5-0.3-0.20.3-0.40.4-0.6-0.6-0.5-0.50.5-0.1-0.00.5-0.3
Reaction time trials correct on left2.02.96.5-2.32.3-2.5-0.8-2.2-2.12.10.81.81.72.0-1.61.7-1.71.71.71.71.6-1.61.2-0.2-1.3-0.2
Reaction time trials on left2.02.96.4-2.32.3-2.5-0.8-2.2-2.12.10.71.81.71.9-1.71.7-1.71.71.71.71.6-1.61.2-0.3-1.3-0.1
Reaction time mean1.31.83.71.7-1.61.41.51.61.6-1.6-1.6-1.3-1.0-1.41.0-1.31.3-0.9-0.9-1.3-1.41.2-1.90.11.3-0.7
Reaction time mean AUC0.60.82.31.2-1.20.91.21.11.1-1.1-1.1-0.9-0.6-0.90.6-0.80.8-0.4-0.4-0.8-0.90.8-1.5-0.10.8-0.4
Median of all reaction times3.04.16.22.4-2.42.21.92.42.4-2.4-2.0-2.1-1.8-2.11.7-2.12.1-1.6-1.6-2.1-2.22.0-2.50.62.0-1.3
Reaction time omissions0.30.41.90.10.0-0.10.5-0.3-0.10.2-0.30.80.90.6-0.90.6-0.60.60.60.60.6-0.70.7-1.4-0.71.2
Reaction time false alarm rate0.91.22.51.5-1.51.61.01.41.4-1.4-1.0-1.1-0.9-0.90.9-1.01.0-1.2-1.2-1.1-1.11.0-0.6-0.00.90.0
Reaction time premature initiation rate2.43.26.62.4-2.42.12.62.02.3-2.3-2.5-1.5-1.1-1.51.0-1.51.5-1.9-1.9-1.6-1.81.6-1.2-0.61.5-0.3
Reaction time premature initiations0.60.84.01.1-1.00.72.00.71.1-1.1-2.0-0.5-0.1-0.50.1-0.60.6-0.9-0.9-0.7-0.80.7-0.5-0.70.8-0.4
Std. dev. reaction times0.50.72.1-0.20.2-0.60.3-0.5-0.40.4-0.20.91.10.6-1.10.9-0.91.21.20.90.8-1.0-0.1-1.4-0.91.1
Reaction time trials completed2.02.96.4-2.32.3-2.5-0.8-2.2-2.12.10.71.81.71.9-1.71.7-1.71.71.71.71.6-1.61.2-0.3-1.3-0.1
Reaction time trials AUC1.52.25.4-2.02.0-2.3-0.4-2.0-1.81.80.31.61.61.7-1.51.5-1.51.51.51.41.3-1.30.8-0.3-1.0-0.4
Run reversals in cocaine runway, females0.30.31.8-0.80.7-0.5-0.5-0.5-0.50.50.3-0.1-0.4-0.10.4-0.10.1-0.7-0.7-0.2-0.10.30.41.30.4-1.3
Run reversals in cocaine runway, males0.70.71.20.7-0.70.9-0.10.90.7-0.70.0-1.0-1.1-1.11.1-1.01.0-0.4-0.4-1.0-0.91.0-0.61.10.9-0.8
Latency to leave start box in cocaine runway0.50.62.11.0-0.90.61.40.80.9-0.9-1.4-0.6-0.2-0.40.2-0.60.6-0.4-0.4-0.6-0.70.6-0.8-0.40.7-0.3
Latency to leave start box in cocaine runway, F0.00.10.20.4-0.30.4-0.00.30.3-0.30.1-0.3-0.20.10.1-0.20.2-0.1-0.1-0.1-0.10.10.3-0.2-0.00.4
Latency to leave start box in cocaine runway, M1.41.46.81.2-1.20.62.60.91.3-1.3-2.6-0.7-0.2-0.70.2-0.70.7-0.8-0.8-0.9-1.20.9-1.4-0.51.2-1.1
Std. dev. time between licks in bursts2.32.73.4-1.61.7-1.6-1.5-1.7-1.81.81.61.71.51.7-1.51.7-1.71.61.61.81.8-1.81.7-1.0-1.81.5
Total sessions with >9 infusions0.30.42.60.1-0.10.2-0.5-0.1-0.20.20.70.40.40.3-0.50.3-0.30.40.40.60.6-0.60.8-1.0-0.81.6
Short access day 1 total inactive lever presses0.20.20.6-0.40.4-0.5-0.1-0.5-0.40.40.10.50.50.5-0.50.4-0.40.50.50.50.5-0.50.8-0.4-0.50.4
Short access day 10 total inactive lever presses0.40.53.0-0.70.7-0.70.7-0.9-0.50.5-0.70.60.60.6-0.60.7-0.7-0.9-0.90.20.3-0.11.7-0.1-0.0-0.5
Short access day 1 total infusions0.30.30.80.7-0.70.9-0.10.70.6-0.60.1-0.6-0.6-0.70.6-0.70.7-0.4-0.4-0.5-0.40.4-0.30.10.30.3
Short access day 10 total infusions0.20.21.30.5-0.40.20.70.20.3-0.3-0.60.20.40.0-0.50.0-0.00.10.10.20.1-0.30.0-1.2-0.30.9
Short access total infusions0.10.10.30.6-0.60.50.20.50.4-0.4-0.2-0.2-0.1-0.30.1-0.40.4-0.1-0.1-0.1-0.20.1-0.5-0.40.00.5
Short access day 1 locomotion0.60.61.41.2-1.21.10.91.01.0-1.0-0.9-0.6-0.4-0.60.4-0.70.7-0.7-0.7-0.6-0.60.5-0.6-0.50.50.4
Short access day 10 total locomotion0.91.04.8-1.21.2-0.7-2.2-0.9-1.21.22.20.50.10.4-0.10.6-0.60.70.70.71.0-0.70.90.7-0.90.5
Short access total locomotion0.40.42.80.2-0.10.10.0-0.2-0.10.10.20.60.70.5-0.80.5-0.50.40.40.70.7-0.70.6-1.4-0.91.7
One hour access (0.3 mA shock)0.81.04.50.2-0.30.10.70.50.5-0.5-0.9-0.8-0.9-0.90.9-0.90.9-0.5-0.5-1.0-1.11.1-1.61.51.3-2.1
Compulsive drug intake0.40.41.60.3-0.30.10.40.40.4-0.4-0.5-0.6-0.6-0.60.6-0.60.6-0.6-0.6-0.7-0.70.7-1.20.80.8-1.3
One hour access (shock baseline)0.20.20.80.6-0.60.50.90.50.6-0.6-0.9-0.3-0.1-0.40.1-0.40.4-0.2-0.2-0.4-0.40.4-0.3-0.30.4-0.1
Social response proportion2.12.311.91.7-1.61.03.41.21.7-1.7-3.4-0.6-0.0-0.90.0-0.80.8-1.2-1.2-1.1-1.41.1-1.5-1.11.3-0.8
Social responses4.25.314.02.9-2.92.33.72.52.8-2.8-3.7-1.9-1.1-1.81.1-1.91.9-1.9-1.9-2.1-2.42.0-2.6-0.62.2-1.1
Social time0.50.62.10.9-0.90.51.40.80.9-0.9-1.4-0.6-0.2-0.50.2-0.50.5-0.1-0.1-0.6-0.80.6-1.4-0.40.7-0.5
Soleus weight0.20.72.10.9-0.90.61.10.90.9-0.9-1.2-0.8-0.5-0.70.5-0.70.7-0.6-0.6-0.7-0.90.7-1.50.00.8-0.7
Bone: stiffness0.81.22.0-1.11.1-1.30.1-1.3-1.11.1-0.01.31.41.3-1.41.3-1.30.90.91.21.1-1.11.0-1.0-1.00.6
Tibialis anterior weight0.20.62.90.7-0.70.21.70.60.7-0.8-1.7-0.40.1-0.4-0.1-0.30.3-0.2-0.2-0.4-0.70.4-1.5-0.60.6-0.6
Time to tail flick, vehicle, before self-admin0.91.01.3-1.01.0-0.9-1.1-1.0-1.11.11.11.00.80.9-0.81.0-1.01.01.01.01.1-1.00.8-0.4-1.10.9
Time to tail flick, vehicle, after self-admin0.40.51.1-0.90.9-0.9-0.8-0.7-0.80.80.80.50.40.5-0.40.5-0.51.01.00.60.6-0.6-0.10.2-0.5-0.1
Time to tail flick, test, before self-admin0.40.41.1-0.20.3-0.50.4-0.5-0.30.3-0.30.80.91.0-0.90.6-0.60.40.40.70.6-0.70.5-1.1-0.60.7
Time to tail flick, test, after self-admin0.50.50.9-0.70.7-0.9-0.2-0.7-0.70.70.20.80.80.8-0.80.7-0.71.01.00.70.7-0.70.3-0.5-0.60.3
Delta time to tail flick, vehicle, before/after SA0.20.20.8-0.80.8-0.9-0.0-0.7-0.60.6-0.00.30.40.4-0.40.3-0.30.60.60.30.2-0.3-0.00.3-0.1-0.7
Delta time to tail flick, test, before/after SA0.10.10.5-0.20.2-0.3-0.3-0.2-0.30.30.30.20.30.2-0.30.3-0.30.70.70.40.3-0.4-0.2-0.3-0.40.4
Tibia length0.92.65.6-0.91.0-1.0-0.3-1.4-1.21.20.51.91.91.8-1.91.8-1.81.11.11.71.8-1.82.4-2.1-1.92.4
Ambulatory time before self-admin0.30.31.0-0.20.2-0.3-0.2-0.4-0.30.30.30.40.70.5-0.70.6-0.60.70.70.60.6-0.70.6-0.9-0.71.0
Ambulatory time after self-admin0.60.71.00.8-0.80.70.80.80.8-0.8-0.8-0.9-0.7-0.80.7-0.70.7-0.7-0.7-0.9-0.90.9-1.00.51.0-0.9
Bone: tissue strength0.50.51.7-0.80.8-0.7-0.6-0.9-0.80.80.60.70.60.8-0.60.8-0.80.30.30.70.8-0.71.3-0.2-0.70.5
Total heroin consumption0.40.42.2-0.80.8-0.4-1.5-0.6-0.80.81.50.3-0.00.20.00.3-0.30.10.10.40.6-0.40.90.6-0.50.3
Bone: trabecular number1.01.63.5-1.81.8-1.9-0.7-1.7-1.61.60.61.31.21.4-1.21.3-1.31.01.01.21.2-1.11.0-0.1-0.9-0.2
Bone: trabecular spacing0.70.92.81.7-1.61.51.01.41.3-1.3-0.9-0.7-0.3-0.60.2-0.60.6-0.1-0.1-0.5-0.60.4-0.8-1.10.21.1
Bone: trabecular thickness0.70.81.90.4-0.50.40.20.70.6-0.6-0.3-0.9-1.0-1.01.0-1.01.0-0.8-0.8-0.9-0.90.9-1.21.21.1-1.4
Bone: trabecular tissue density2.63.612.00.3-0.51.0-0.61.00.8-0.90.3-2.0-2.5-2.02.6-2.02.0-2.3-2.3-2.1-1.82.2-0.93.52.2-3.1
Water consumed over 24 hours0.20.30.80.6-0.60.40.80.60.6-0.6-0.8-0.3-0.3-0.30.3-0.30.3-0.7-0.7-0.4-0.50.4-0.9-0.10.5-0.4
Number of responses in last shaping day0.30.30.80.9-0.80.80.40.70.7-0.7-0.3-0.3-0.1-0.30.1-0.40.4-0.4-0.4-0.2-0.20.10.1-0.70.00.9