Hub : Genes

Isoc2a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Isoc2a 0.05 0.03 3.1e-06 0.04 0.06 0.04 0.05 1.2e-04 5.7e-06 1.7e-04 4.2e-05
2 RMTg gene expression Isoc2a 0.27 0.14 3.0e-06 0.17 0.2 0.14 0.2 3.1e-05 4.8e-06 1.6e-04 5.0e-06
3 LHb gene expression Isoc2a 0.25 0.13 2.4e-05 0.2 0.16 0.2 0.19 1.6e-05 1.1e-04 2.0e-05 3.4e-05
4 NAcc gene expression Isoc2a 0.07 0.07 4.9e-07 0.04 0.03 0.04 0.04 4.6e-06 5.6e-06 1.2e-06 3.6e-06
5 PL gene expression Isoc2a 0.08 0.05 8.8e-10 0.06 0.08 0.07 0.07 1.3e-07 1.2e-08 2.7e-08 3.2e-08
6 IL gene expression Isoc2a 0.29 0.15 2.8e-06 0.29 0.18 0.2 0.24 1.2e-07 3.8e-05 1.9e-05 1.4e-06
7 NAcc mRNA stability Isoc2a 0.03 0.02 7.9e-03 0.02 0.01 0.01 0.01 1.2e-03 1.0e-02 5.6e-03 3.1e-03
8 BLA gene expression Isoc2a 0.23 0.13 2.9e-06 0.08 0.09 0.1 0.09 3.3e-05 1.5e-05 4.6e-06 1.8e-05
9 Adipose gene expression Isoc2a 0.08 0.05 2.3e-05 0.01 0.04 0.03 0.02 6.7e-02 1.7e-05 5.8e-04 1.7e-03
10 pVTA gene expression Isoc2a 0.08 0.06 6.0e-04 0 0.02 0.02 0.01 2.9e-01 1.2e-02 1.8e-02 6.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.10.20.40.40.40.60.40.50.4-0.40.30.40.4
Area under the delay curve0.40.51.1-0.7-0.7-0.6-0.6-0.6-1.01.0-0.5-0.3-0.2
BMI with tail0.51.62.2-1.3-1.3-1.4-1.5-1.4-1.21.2-1.1-1.2-1.0
BMI without tail0.00.10.30.50.5-0.00.20.1-0.10.1-0.2-0.4-0.5
Body weight0.62.75.52.32.31.51.91.71.7-1.71.40.50.2
Weight adjusted by age0.91.31.80.80.61.31.21.11.2-1.21.11.31.3
Bone surface2.34.26.12.52.42.32.22.22.1-2.11.91.31.0
Bone volume1.93.54.92.22.22.22.02.01.9-1.91.61.20.9
Breakpoint value in progressive ratio session0.20.30.5-0.7-0.7-0.6-0.6-0.7-0.30.3-0.2-0.4-0.2
Number of licking bursts0.10.10.3-0.3-0.3-0.5-0.2-0.3-0.40.4-0.4-0.3-0.2
Context. condit. distance diff. score0.20.30.7-0.6-0.7-0.0-0.2-0.10.5-0.50.80.60.7
Locomotion velocity, session 11.81.95.9-0.4-0.71.10.60.81.3-1.31.52.22.4
Locomotion distance, session 14.15.27.51.41.22.52.02.12.7-2.72.62.52.5
Locomotion velocity, session 20.20.31.1-0.5-0.6-0.00.10.20.3-0.30.30.91.0
Locomotion distance, session 22.12.94.41.51.42.11.91.91.5-1.51.71.81.7
Locomotion velocity, session 30.10.10.2-0.3-0.30.0-0.1-0.00.5-0.50.10.20.3
Locomotion distance, session 30.70.71.30.30.20.80.60.71.1-1.10.91.01.0
Stereotopy head waving bouts, day 30.10.10.2-0.3-0.3-0.4-0.5-0.50.3-0.3-0.1-0.4-0.4
Stereotopy head waving duration, day 30.10.20.3-0.3-0.3-0.4-0.5-0.50.2-0.2-0.2-0.5-0.5
Locomotion velocity, session 70.50.51.20.10.00.60.30.51.1-1.10.80.80.8
Locomotion distance, session 70.30.31.1-0.1-0.20.60.40.40.3-0.30.61.01.0
Stereotopy head waving bouts, day 70.20.20.60.40.5-0.00.10.10.8-0.80.3-0.3-0.3
Stereotopy head waving duration, day 70.20.20.50.50.5-0.10.10.20.7-0.70.3-0.2-0.3
Locomotion velocity, session 80.60.71.6-0.3-0.40.60.30.41.1-1.11.11.21.3
Locomotion distance, session 80.71.02.20.1-0.00.90.70.71.0-1.01.51.41.5
Degree of sensitization distance0.00.00.10.0-0.00.10.10.10.0-0.00.30.20.2
Degree of sensitization stereotypy0.10.10.20.20.2-0.3-0.1-0.10.3-0.30.0-0.4-0.5
Conditioned locomotion0.40.50.9-0.0-0.10.50.30.40.9-0.91.00.91.0
Cocaine response after cond. corrected2.83.45.3-1.1-0.9-1.7-1.7-1.7-2.12.1-2.3-2.1-2.2
Cocaine response after cond. not corrected0.40.41.20.50.6-0.2-0.1-0.1-0.70.7-0.9-0.9-1.1
Cocaine response before conditioning6.88.19.62.92.83.03.13.12.9-2.92.92.52.2
Saline control response1.01.33.5-0.1-0.30.60.40.61.9-1.91.21.31.4
Bone: connectivity density0.00.00.1-0.2-0.2-0.0-0.2-0.2-0.20.2-0.3-0.1-0.1
Bone: cortical apparent density0.30.41.00.10.10.70.60.6-0.30.30.21.01.0
Bone: cortical area0.81.22.01.11.11.01.01.01.4-1.41.20.70.6
Bone: cortical porosity0.50.61.0-0.7-0.6-0.8-1.0-0.9-0.20.2-0.7-1.0-1.0
Bone: cortical porosity0.30.41.2-0.2-0.1-0.5-0.7-0.60.2-0.2-0.5-1.0-1.1
Bone: cortical thickness0.10.20.7-0.8-0.8-0.4-0.6-0.50.1-0.1-0.2-0.00.1
Bone: cortical thickness0.20.20.40.30.20.50.60.5-0.40.40.10.60.6
Bone: cortical tissue density0.20.30.90.10.00.70.50.6-0.40.40.10.90.9
Condit. Reinf. active minus inactive responses0.10.20.3-0.5-0.5-0.4-0.6-0.50.2-0.2-0.2-0.4-0.4
Condit. Reinf. active-inactive response ratio1.41.52.2-1.4-1.4-1.4-1.5-1.5-1.01.0-1.0-1.1-0.9
Condit. Reinf. active responses0.30.31.20.40.40.50.20.31.1-1.10.50.20.1
Condit. Reinf. inactive responses3.54.36.42.01.92.32.02.12.5-2.52.11.61.4
Incentive salience index mean0.10.10.30.20.20.40.20.30.6-0.60.40.20.2
Condit. Reinf. lever presses0.60.91.61.11.01.31.11.10.5-0.50.70.80.7
Condit. Reinf. active minus inactive responses2.83.75.22.22.22.02.32.11.8-1.81.91.41.2
Condit. Reinf. active-inactive response ratio3.44.07.92.82.82.22.42.31.4-1.41.51.10.7
Condit. Reinf. active responses2.94.15.61.91.81.92.22.12.2-2.22.41.81.7
Condit. Reinf. inactive responses0.40.51.4-0.2-0.30.10.20.11.1-1.11.20.70.8
Condit. Reinf. lever presses0.30.41.00.91.00.10.50.30.7-0.70.3-0.5-0.6
Condit. Reinf. lever reinforcers received3.85.36.92.22.02.22.52.42.5-2.52.62.01.9
Conditioned reinforcement - actives0.10.20.50.70.70.70.20.40.2-0.20.10.0-0.1
Conditioned reinforcement - inactives1.92.95.41.91.92.31.92.01.1-1.11.41.51.3
Conditioned locomotion0.10.10.20.40.50.50.10.3-0.30.30.1-0.1-0.2
Patch foraging indifference point 0 sec0.30.51.2-0.9-1.1-0.1-0.6-0.40.7-0.70.70.60.8
Patch foraging indifference point AUC0.40.60.8-0.9-0.8-0.9-0.9-0.9-0.50.5-0.9-0.7-0.6
Delay disc. indifference point, 0s delay0.40.41.6-0.2-0.40.60.40.40.4-0.40.61.11.3
Delay disc. indifference point, 16s delay1.71.92.9-0.7-0.5-1.5-1.3-1.3-1.61.6-1.3-1.7-1.7
Delay disc. indifference point, 2s delay0.60.72.0-0.8-0.8-0.5-0.4-0.5-1.41.4-0.9-0.10.0
Delay disc. indifference point, 24s delay1.11.22.3-0.8-0.7-1.1-1.1-1.0-1.51.5-0.8-1.1-1.0
Delay disc. indifference point, 4s delay0.00.00.10.30.30.00.10.1-0.30.3-0.2-0.1-0.1
Delay disc. indifference point, 8s delay0.10.10.2-0.4-0.4-0.2-0.2-0.2-0.40.4-0.10.10.2
Indifference point function ln k4.17.19.22.72.63.03.03.02.5-2.52.72.52.2
Indifference point function log k4.17.19.22.72.63.03.03.02.5-2.52.72.52.2
Patch foraging total patch changes 0 sec0.20.41.1-0.9-1.1-0.2-0.5-0.40.4-0.40.70.60.8
Patch foraging total patch changes 12 sec0.20.20.5-0.6-0.6-0.4-0.7-0.60.1-0.10.1-0.3-0.2
Patch foraging total patch changes 18 sec0.30.51.3-1.1-1.1-0.8-0.9-0.90.4-0.40.1-0.2-0.0
Patch foraging total patch changes 24 sec0.10.20.60.10.2-0.5-0.3-0.3-0.40.4-0.3-0.7-0.8
Patch foraging total patch changes 6 sec0.50.71.7-1.3-1.3-0.9-1.3-1.1-0.10.1-0.2-0.5-0.3
Patch foraging time to switch 0 sec3.77.613.0-1.5-1.2-2.9-2.7-2.7-2.62.6-3.0-3.6-3.6
Patch foraging water rate 0 sec1.02.03.80.60.41.51.31.31.3-1.31.71.92.0
Patch foraging water rate 12 sec2.34.87.11.41.12.32.42.22.2-2.22.42.72.6
Patch foraging water rate 18 sec1.42.23.30.90.71.51.51.51.5-1.51.61.81.8
Patch foraging water rate 24 sec1.21.72.10.90.81.31.31.31.4-1.41.41.51.4
Patch foraging water rate 6 sec4.16.08.83.02.92.52.92.72.5-2.52.01.61.2
Seeking ratio, delayed vs. immediate footshock1.11.33.1-0.2-0.41.00.60.61.3-1.31.51.61.7
Distance traveled before self-admin3.85.09.01.10.82.52.22.12.0-2.02.53.03.0
Distance traveled after self-admin0.60.72.3-0.9-1.10.30.10.00.4-0.41.11.21.5
Extensor digitorum longus weight0.10.41.11.01.10.40.60.60.4-0.40.3-0.1-0.3
Bone: elastic displacement0.40.41.2-0.7-0.8-0.0-0.5-0.31.1-1.10.40.20.3
Bone: elastic work0.91.12.10.70.61.20.90.91.5-1.51.11.01.0
Bone: endosteal estimation1.83.97.22.72.72.02.32.21.7-1.71.81.00.7
Bone: endosteal perimeter1.32.83.92.01.91.61.81.71.7-1.71.91.10.9
Epididymis fat weight0.20.92.80.20.4-0.8-0.6-0.6-0.70.7-0.9-1.5-1.7
Delta time in closed arm before/after self-admin0.10.10.2-0.2-0.2-0.0-0.3-0.1-0.50.5-0.4-0.1-0.1
Delta time in open arm before/after self-admin2.32.33.91.21.11.51.51.42.0-2.01.71.31.3
Diff in mean of infusions in LGA sessions0.30.41.1-0.1-0.20.60.50.40.6-0.60.51.01.0
Delay discount exponential model param0.30.40.90.60.60.50.50.51.0-1.00.40.30.2
Extinction: sum of active levers before priming0.10.10.2-0.4-0.4-0.00.0-0.1-0.00.00.30.40.5
Active lever presses in extinction session 61.01.02.50.00.2-0.9-0.7-0.7-1.11.1-1.0-1.5-1.6
Bone: final force1.62.64.22.02.02.01.91.91.1-1.11.21.20.9
Bone: final moment2.23.55.12.32.22.32.22.21.5-1.51.51.51.2
Food consumed during 24 hour testing period1.41.92.51.61.51.51.61.51.2-1.21.41.10.9
Glucose1.01.63.8-1.9-1.9-1.4-1.3-1.4-1.01.0-0.7-0.20.1
Heart weight0.71.13.01.71.71.21.21.20.7-0.70.60.2-0.1
Delay discount hyperbolic model param0.40.51.20.70.70.60.50.61.1-1.10.50.30.2
Intermittent access intake day 1-15 change0.30.61.21.11.10.81.11.00.4-0.40.50.50.4
Intermittent access intake escalation0.40.82.01.41.40.91.31.10.4-0.40.50.40.2
Intermittent access intake escalation 20.30.30.60.30.30.60.70.60.3-0.30.50.80.8
Intermitt. access day 1 inactive lever presses0.31.12.91.71.71.21.21.20.7-0.70.70.30.0
Intermitt. access day 15 inactive lever presses1.02.15.62.32.41.71.51.70.9-0.90.90.4-0.0
Intermitt. access escalation Index0.40.61.5-0.8-0.9-0.5-0.6-0.7-1.21.2-0.2-0.2-0.0
Intermittent access day 1 total infusions0.20.30.80.90.90.90.60.60.3-0.30.50.20.1
Intermittent access day 15 total infusions0.40.61.91.31.41.01.00.9-0.10.10.30.1-0.1
Intermittent access terminal intake (last 3 days)0.50.61.61.21.21.01.00.9-0.10.10.30.30.1
Intermittent access total infusions0.91.02.31.51.51.41.21.20.4-0.40.60.50.3
Intermittent access day 1 locomotion0.70.92.01.31.31.41.21.2-0.00.00.80.60.5
Intermittent access day 15 total locomotion0.91.63.11.21.11.41.81.50.5-0.51.01.51.4
Intermittent access total locomotion2.12.54.42.01.92.02.11.90.6-0.61.31.31.1
Intermittent access standard deviation0.10.30.7-0.6-0.6-0.5-0.3-0.4-0.80.8-0.5-0.10.0
Left kidney weight4.018.426.15.15.04.44.74.64.7-4.74.12.62.1
Right kidney weight3.616.627.15.25.24.34.44.44.2-4.23.82.11.5
Cocaine induced anxiety0.91.22.11.21.11.11.01.11.4-1.41.20.70.5
Post-drug Anxiety0.40.40.90.91.00.20.40.40.8-0.80.3-0.3-0.5
Baseline Anxiety0.80.91.2-0.8-0.7-1.1-0.9-0.9-1.01.0-1.1-0.9-0.8
Tail length2.28.714.03.73.73.03.43.32.9-2.92.41.81.3
Length with tail1.87.714.93.83.92.63.33.02.7-2.72.21.20.7
Length without tail0.62.05.92.32.41.01.51.31.2-1.20.7-0.3-0.6
Times rat made contact with spout0.10.20.3-0.2-0.2-0.4-0.4-0.4-0.20.2-0.4-0.6-0.6
Lifetime Intake0.60.71.71.31.31.20.91.00.2-0.20.40.40.2
Liver weight, left0.61.01.81.31.31.01.21.10.9-0.90.90.60.4
Liver weight, right0.00.10.5-0.0-0.10.2-0.1-0.00.3-0.30.70.10.2
Locomotor activity0.20.30.5-0.4-0.3-0.6-0.4-0.6-0.70.7-0.5-0.6-0.6
Locomotor testing distance0.20.30.80.20.3-0.4-0.2-0.3-0.60.6-0.5-0.8-0.9
Locomotor testing rearing0.20.40.70.80.80.60.60.60.5-0.50.70.20.2
Locomotion in novel chamber1.01.32.4-1.5-1.5-1.2-1.1-1.2-1.31.3-0.7-0.4-0.1
Locomotion in novel chamber post-restriction0.61.01.9-0.9-0.9-0.8-1.0-1.0-1.41.4-0.9-0.7-0.6
Fecal boli incidents, locomotor time 10.20.30.60.50.40.60.70.60.3-0.30.50.60.6
Change in fecal boli incidents, locomotor task2.12.13.2-1.8-1.8-1.4-1.5-1.5-1.71.7-1.3-0.7-0.5
Time >=10cm from walls, locomotor time 10.00.10.1-0.1-0.0-0.2-0.3-0.2-0.10.1-0.3-0.3-0.4
Bouts of movement, locomotor time 11.82.04.50.2-0.01.41.21.11.5-1.51.62.02.1
Total resting periods, locomotor time 10.50.61.9-0.2-0.40.60.60.40.6-0.60.81.21.4
Rest time, locomotor task time 10.70.91.71.31.31.01.31.10.4-0.40.60.70.5
Distance moved, locomotor task time 10.71.01.9-1.4-1.4-1.2-1.3-1.2-0.50.5-0.7-0.7-0.5
Vertical activity count, locomotor time 10.61.65.0-2.1-2.2-1.2-1.4-1.4-0.50.5-0.50.00.4
Time >=10cm from walls, locomotor time 20.60.91.2-0.8-0.7-1.0-1.0-1.0-0.90.9-1.1-0.9-0.9
Bouts of movement, locomotor time 20.00.00.00.10.10.10.10.10.0-0.00.20.10.1
Total resting periods, locomotor time 20.00.00.10.10.10.20.20.2-0.00.00.20.30.3
Rest time, locomotor task time 20.20.20.7-0.0-0.10.50.40.40.3-0.30.50.80.9
Distance moved, locomotor task time 20.10.10.2-0.4-0.4-0.4-0.5-0.4-0.00.0-0.2-0.3-0.3
Vertical activity count, locomotor time 20.10.10.5-0.6-0.7-0.4-0.3-0.4-0.10.1-0.10.10.2
Light reinforcement 10.51.12.5-0.3-0.51.00.20.51.3-1.31.11.41.6
Light reinforcement 20.61.02.3-1.5-1.5-1.0-1.1-1.0-0.60.6-1.0-0.20.0
Bone: marrow area1.84.07.22.72.72.02.32.21.7-1.71.81.00.7
Bone: maximum diameter0.61.12.01.41.40.91.11.01.3-1.31.10.30.1
Bone: maximum force2.23.96.32.52.52.22.22.21.8-1.81.71.20.9
Bone: maximum moment2.74.87.12.72.62.52.52.42.1-2.11.91.51.2
Mean time between licks in bursts0.10.30.9-0.9-1.0-0.1-0.5-0.4-0.50.5-0.10.30.5
Mean num. licks in bursts0.10.10.20.40.40.40.20.20.2-0.20.3-0.1-0.1
Cd content in liver1.82.02.81.61.51.61.71.61.1-1.11.41.21.1
Co content in liver1.21.42.60.90.81.51.41.40.8-0.80.71.61.5
Cu content in liver0.60.71.61.21.30.91.01.00.7-0.70.20.30.1
Fe content in liver0.20.20.50.70.70.50.60.60.5-0.50.10.20.1
K content in liver0.00.00.20.00.0-0.0-0.1-0.00.4-0.4-0.0-0.1-0.1
Mg content in liver0.30.30.9-0.2-0.1-0.6-0.5-0.5-0.20.2-0.7-0.9-0.9
Mn content in liver0.20.20.5-0.00.1-0.4-0.4-0.30.6-0.6-0.2-0.7-0.7
Na content in liver1.92.03.6-1.9-1.8-1.7-1.8-1.7-0.70.7-1.1-1.0-0.8
Rb content in liver1.92.24.22.02.01.31.41.42.0-2.00.90.3-0.0
Se content in liver2.12.43.7-1.6-1.6-1.9-1.9-1.9-1.11.1-1.2-1.6-1.4
Sr content in liver2.72.36.7-2.5-2.6-1.3-1.7-1.6-1.01.0-1.1-0.10.3
Zn content in liver1.61.73.1-0.5-0.3-1.2-1.0-1.1-1.71.7-1.6-1.6-1.6
Bone: minimum diameter2.95.37.22.52.42.32.32.32.7-2.72.51.61.3
Time in familiar zone, hab. session 14.03.85.81.61.42.22.32.21.2-1.22.32.42.4
Time in novel zone, hab. session 12.22.23.5-1.6-1.4-1.7-1.9-1.7-0.70.7-1.6-1.6-1.5
Total zone transitions, hab. session 12.12.95.20.70.52.01.41.61.8-1.81.72.32.3
Total locomotion distance, hab. session 10.91.33.20.20.01.30.91.00.9-0.91.21.71.8
Locomotion velocity, hab. session 10.60.82.10.20.11.10.80.80.7-0.70.91.41.4
Time in familiar zone, hab. session 21.21.33.81.91.90.91.51.30.5-0.50.70.2-0.1
Time in novel zone, hab. session 20.90.92.1-1.4-1.4-0.8-1.3-1.1-0.40.4-0.8-0.5-0.3
Total zone transitions, hab. session 23.54.56.61.41.32.31.82.02.6-2.62.62.22.1
Total locomotion distance, hab. session 20.60.81.9-0.1-0.20.90.40.60.9-0.91.21.31.4
Locomotion velocity, hab. session 20.60.82.1-0.2-0.40.80.30.50.9-0.91.21.31.4
Novel to familiar place preference ratio0.00.00.00.10.2-0.1-0.0-0.00.2-0.20.1-0.2-0.2
Novelty place preference0.10.10.20.30.30.20.30.20.4-0.40.40.10.1
Time in novel zone, NPP test0.10.10.20.40.40.20.30.30.4-0.40.40.10.0
Total zone transitions, NPP test0.70.91.70.40.21.00.80.81.0-1.01.31.31.3
Total locomotion distance, NPP test0.40.50.90.60.50.80.60.61.0-1.00.90.60.6
Locomotion velocity, NPP test0.60.81.50.50.50.90.70.81.2-1.21.10.90.9
Intraocular pressure0.00.00.2-0.1-0.1-0.1-0.1-0.00.3-0.3-0.40.0-0.0
Delta distance traveled before/after self-admin1.81.92.9-1.6-1.6-1.7-1.7-1.7-1.01.0-1.1-1.2-1.0
Delta ambulatory time before/after self-admin1.01.32.1-1.4-1.4-1.3-1.4-1.4-0.70.7-0.9-0.9-0.7
Parametrial fat weight1.74.04.9-2.1-2.1-2.2-2.1-2.2-2.22.2-1.7-1.5-1.2
Pavlov. Cond. lever latency0.00.00.1-0.3-0.3-0.3-0.2-0.20.0-0.0-0.3-0.0-0.0
Pavlov. Cond. magazine entry latency1.01.32.0-0.8-0.7-1.3-1.1-1.1-1.41.4-1.2-1.2-1.1
Pavlov. Cond. change in total contacts0.20.20.4-0.6-0.6-0.6-0.5-0.5-0.50.5-0.3-0.2-0.1
Pavlov. Cond. index score0.30.41.0-0.6-0.6-0.6-0.6-0.6-1.01.0-0.4-0.4-0.4
Pavlov. Cond. latency score0.30.41.0-0.5-0.5-0.5-0.5-0.5-1.01.0-0.4-0.4-0.4
Pavlov. Cond. lever contacts0.00.10.20.40.40.10.10.0-0.00.00.2-0.3-0.4
Pavlov. Cond. magazine entry number0.40.50.90.50.40.70.60.60.9-0.90.60.70.6
Pavlov. Cond. intertrial magazine entries1.01.22.5-0.4-0.60.60.30.41.5-1.51.21.41.6
Pavlov. Cond. lever-magazine prob. diff.0.40.40.9-0.6-0.6-0.6-0.6-0.6-0.90.9-0.5-0.5-0.4
Pavlov. Cond. response bias0.20.30.70.00.1-0.5-0.3-0.4-0.70.7-0.6-0.8-0.8
Pavlov. Cond. lever latency0.30.40.80.60.60.90.60.70.2-0.20.70.60.5
Pavlov. Cond. magazine entry latency0.81.01.7-0.9-0.9-1.3-1.1-1.1-0.60.6-1.1-1.1-1.0
Pavlov. Cond. change in total contacts0.20.41.20.40.30.30.40.41.1-1.10.40.40.4
Pavlov. Cond. index score0.10.20.4-0.1-0.1-0.5-0.3-0.30.2-0.2-0.6-0.6-0.6
Pavlov. Cond. latency score0.40.51.0-0.6-0.5-1.0-0.8-0.8-0.20.2-1.0-0.9-0.9
Pavlov. Cond. lever contacts0.10.20.4-0.2-0.2-0.6-0.3-0.40.0-0.0-0.5-0.5-0.5
Pavlov. Cond. magazine entry number0.50.61.10.70.61.00.80.80.8-0.81.00.80.7
Pavlov. Cond. intertrial magazine entries2.33.54.92.22.22.12.22.11.6-1.61.81.41.2
Pavlov. Cond. lever-magazine prob. diff.0.10.20.5-0.3-0.2-0.6-0.4-0.4-0.00.0-0.7-0.5-0.5
Pavlov. Cond. response bias0.10.10.40.40.50.00.20.20.6-0.6-0.1-0.2-0.2
Time in closed arm before self-admin0.60.81.41.01.00.80.90.91.2-1.20.70.50.4
Time in closed arm after self-admin0.10.20.50.40.5-0.1-0.1-0.00.2-0.2-0.5-0.5-0.7
Time in open arm before self-admin1.61.82.6-1.6-1.6-1.3-1.6-1.5-1.31.3-1.2-0.9-0.7
Time in open arm after self-admin0.10.10.4-0.5-0.6-0.0-0.1-0.10.1-0.10.40.40.6
Bone: periosteal estimation1.63.45.12.32.21.92.01.91.9-1.91.81.10.8
Bone: periosteal perimeter1.52.63.31.81.71.61.71.71.8-1.81.71.10.9
Bone: post-yield work1.72.45.72.32.41.41.81.71.4-1.41.10.40.0
Progressive ratio test 1 active lever presses1.62.03.50.90.81.91.01.31.8-1.81.41.41.4
Progressive ratio test 1 breakpoint1.51.93.30.90.81.81.01.31.7-1.71.31.41.4
Progressive ratio test 1 inactive lever presses2.43.56.12.12.12.51.92.21.7-1.71.51.51.2
Progressive ratio test 2 active lever presses0.30.41.11.01.10.80.50.60.5-0.50.2-0.1-0.3
Progressive ratio test 2 breakpoint0.40.51.41.11.20.80.50.70.5-0.50.2-0.1-0.3
Progressive ratio test 2 inactive lever presses2.13.45.32.32.32.32.12.11.4-1.41.51.31.0
Incentive Sensitization - Responses0.60.92.91.61.70.70.90.90.5-0.50.3-0.3-0.6
Incentive Sensitization - Breakpoint0.40.62.11.31.40.40.70.60.3-0.30.1-0.5-0.7
Sum of active levers in priming session hrs 5-60.10.10.4-0.3-0.30.10.20.10.1-0.10.50.50.6
Progressive ratio0.20.30.9-0.0-0.10.30.30.30.9-0.90.70.70.7
Food seeking constrained by brief footshock4.45.414.5-0.4-0.82.11.41.52.3-2.32.63.53.8
Seeking ratio, punishment vs. effort0.71.01.70.60.51.21.11.00.7-0.71.01.31.3
Retroperitoneal fat weight4.318.522.6-4.1-3.9-4.8-4.6-4.7-4.54.5-4.1-4.0-3.6
Reaction time number correct0.10.20.7-0.5-0.6-0.3-0.2-0.3-0.80.8-0.30.10.2
Reaction time mean minus median0.10.20.90.00.0-0.10.20.0-0.90.9-0.40.00.0
Reaction time mean minus median AUC0.10.20.8-0.0-0.0-0.2-0.0-0.2-0.90.9-0.5-0.3-0.3
Reaction time num false alarms0.00.00.20.10.1-0.10.00.1-0.40.4-0.3-0.0-0.1
Reaction time num false alarms AUC0.10.10.3-0.5-0.5-0.2-0.1-0.1-0.50.5-0.30.30.4
Reaction time trials correct on left0.10.20.7-0.5-0.6-0.3-0.2-0.3-0.80.8-0.30.10.2
Reaction time trials on left0.10.20.7-0.5-0.6-0.3-0.2-0.3-0.80.8-0.30.10.2
Reaction time mean0.30.51.61.21.30.50.80.7-0.10.1-0.2-0.1-0.4
Reaction time mean AUC0.20.30.80.70.90.10.30.3-0.60.6-0.6-0.5-0.7
Median of all reaction times0.30.51.71.21.30.50.70.70.0-0.0-0.4-0.3-0.6
Reaction time omissions0.10.10.4-0.2-0.30.10.30.20.1-0.1-0.00.60.6
Reaction time false alarm rate0.00.00.1-0.1-0.2-0.00.00.10.0-0.0-0.10.30.3
Reaction time premature initiation rate0.00.10.20.10.1-0.10.1-0.1-0.40.4-0.2-0.2-0.3
Reaction time premature initiations0.20.30.8-0.2-0.2-0.5-0.2-0.4-0.90.9-0.5-0.4-0.4
Std. dev. reaction times0.20.30.90.91.00.40.70.6-0.40.4-0.1-0.0-0.2
Reaction time trials completed0.10.20.7-0.5-0.6-0.3-0.2-0.3-0.80.8-0.30.10.2
Reaction time trials AUC0.10.20.8-0.5-0.5-0.4-0.2-0.3-0.90.9-0.4-0.00.1
Run reversals in cocaine runway, females0.20.20.60.70.80.30.20.40.6-0.60.1-0.3-0.5
Run reversals in cocaine runway, males0.00.00.10.20.2-0.00.00.10.0-0.0-0.3-0.1-0.2
Latency to leave start box in cocaine runway0.30.30.80.90.90.40.90.70.2-0.20.10.30.2
Latency to leave start box in cocaine runway, F0.00.10.10.30.30.10.40.3-0.10.1-0.20.10.0
Latency to leave start box in cocaine runway, M0.80.81.81.31.30.81.21.10.6-0.60.40.40.2
Std. dev. time between licks in bursts0.60.82.5-0.4-0.60.80.20.50.9-0.91.01.41.6
Total sessions with >9 infusions1.21.52.91.11.01.71.11.31.1-1.11.21.21.2
Short access day 1 total inactive lever presses0.30.41.51.11.20.50.60.6-0.10.10.0-0.3-0.4
Short access day 10 total inactive lever presses0.10.20.30.50.5-0.10.50.3-0.50.5-0.2-0.1-0.1
Short access day 1 total infusions0.00.00.10.10.10.30.10.2-0.20.2-0.10.20.2
Short access day 10 total infusions0.00.00.1-0.1-0.10.30.00.0-0.30.3-0.00.20.3
Short access total infusions0.10.10.2-0.2-0.20.2-0.2-0.1-0.50.5-0.20.10.1
Short access day 1 locomotion0.20.20.70.70.70.80.50.60.1-0.10.30.20.1
Short access day 10 total locomotion0.81.53.30.70.51.41.51.30.5-0.51.31.81.8
Short access total locomotion1.11.33.40.30.11.51.01.00.4-0.41.31.71.8
One hour access (0.3 mA shock)2.63.05.82.42.42.02.12.11.2-1.21.31.00.7
Compulsive drug intake1.31.52.41.61.61.01.51.31.3-1.30.90.70.5
One hour access (shock baseline)0.20.30.90.91.00.80.30.5-0.30.3-0.0-0.2-0.4
Social response proportion0.40.51.71.21.30.40.60.6-0.20.2-0.2-0.4-0.7
Social responses2.12.75.02.22.21.81.81.81.6-1.61.10.80.4
Social time4.15.67.52.01.82.72.42.52.2-2.22.72.52.3
Soleus weight0.00.10.40.20.20.20.30.20.2-0.20.60.20.2
Bone: stiffness1.82.95.12.32.21.82.12.01.4-1.41.31.00.8
Tibialis anterior weight0.82.74.1-1.7-1.6-2.0-1.9-2.0-1.41.4-0.9-1.7-1.5
Time to tail flick, vehicle, before self-admin0.60.71.10.50.40.81.00.80.8-0.80.81.01.0
Time to tail flick, vehicle, after self-admin0.30.40.80.70.8-0.10.50.2-0.90.9-0.4-0.5-0.6
Time to tail flick, test, before self-admin0.60.62.2-0.6-0.80.50.40.20.4-0.40.61.31.5
Time to tail flick, test, after self-admin0.20.20.4-0.4-0.3-0.4-0.7-0.5-0.10.1-0.3-0.5-0.5
Delta time to tail flick, vehicle, before/after SA1.41.43.5-0.10.0-1.0-0.6-0.7-1.91.9-1.3-1.2-1.3
Delta time to tail flick, test, before/after SA0.30.31.00.50.7-0.1-0.3-0.00.3-0.3-0.2-0.8-1.0
Tibia length2.67.111.23.33.32.72.82.82.8-2.82.61.41.0
Ambulatory time before self-admin2.63.86.11.10.92.22.01.91.9-1.92.22.52.5
Ambulatory time after self-admin1.21.43.3-0.2-0.41.00.60.71.3-1.31.71.71.8
Bone: tissue strength1.01.02.90.1-0.11.10.80.80.5-0.51.41.61.7
Total heroin consumption0.10.10.2-0.2-0.20.20.10.10.3-0.30.50.40.4
Bone: trabecular number0.10.10.3-0.5-0.5-0.1-0.3-0.3-0.60.6-0.20.10.1
Bone: trabecular spacing0.00.00.10.00.0-0.1-0.2-0.10.4-0.40.1-0.2-0.2
Bone: trabecular thickness0.00.00.10.10.10.30.10.1-0.10.10.10.10.0
Bone: trabecular tissue density0.91.42.3-0.9-0.8-1.5-1.2-1.2-1.01.0-1.2-1.4-1.3
Water consumed over 24 hours1.01.41.81.00.91.31.31.31.1-1.11.31.31.2
Number of responses in last shaping day0.20.20.70.20.30.1-0.2-0.0-0.90.9-0.4-0.4-0.5