Hub : Genes

Igf1r

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Igf1r 0.26 0.15 9.8e-03 0.05 0.1 0.05 0.04 2.1e-02 2.4e-03 2.1e-02 4.0e-02
2 Adipose mRNA stability Igf1r 0.07 0.04 2.1e-06 0.07 0.05 0.04 0.06 3.0e-08 3.1e-06 1.2e-05 2.0e-07
3 PL gene expression Igf1r 0.27 0.09 0.0e+00 0.24 0.26 0.26 0.26 2.5e-26 8.5e-28 6.2e-28 2.4e-28
4 Brain gene expression Igf1r 0.53 0.12 0.0e+00 0.48 0.5 0.51 0.51 1.1e-50 7.4e-53 7.7e-55 5.1e-55
5 OFC gene expression Igf1r 0.41 0.16 4.0e-05 0.12 0.15 0.12 0.16 7.2e-04 1.8e-04 1.1e-03 1.0e-04
6 NAcc gene expression Igf1r 0.33 0.11 0.0e+00 0.27 0.32 0.32 0.33 3.3e-41 4.7e-50 2.1e-50 9.5e-51
7 Eye gene expression Igf1r 0.47 0.17 2.6e-03 0.11 0.14 0.24 0.26 9.7e-03 3.4e-03 1.3e-04 6.7e-05
8 pVTA gene expression Igf1r 0.42 0.12 0.0e+00 0.25 0.35 0.34 0.34 2.5e-20 6.9e-29 2.4e-28 1.2e-28
9 IC gene expression Igf1r 0.38 0.13 1.9e-11 0.21 0.23 0.2 0.3 3.7e-09 5.0e-10 1.3e-08 2.6e-13
10 BLA gene expression Igf1r 0.45 0.13 0.0e+00 0.26 0.32 0.32 0.32 4.4e-14 2.8e-17 1.8e-17 3.4e-17
11 Adipose gene expression Igf1r 0.06 0.03 4.1e-06 0.02 0.04 0.03 0.03 2.2e-03 2.0e-05 3.9e-04 2.9e-04
12 Brain mRNA stability Igf1r 0.71 0.08 0.0e+00 0.62 0.52 0.64 0.63 2.5e-74 1.1e-56 1.4e-76 3.9e-75

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.00.10.30.20.60.20.20.20.40.30.20.30.20.20.0
Area under the delay curve0.30.30.60.70.60.40.60.50.30.80.70.70.60.10.6
BMI with tail2.27.418.7-3.4-4.3-2.6-2.9-2.0-2.8-2.1-2.4-2.7-2.6-2.3-1.6
BMI without tail1.75.213.2-3.2-3.6-2.3-2.5-1.8-2.5-1.8-1.9-2.0-2.2-1.3-0.9
Body weight2.611.229.5-4.7-5.4-3.3-3.6-2.6-3.7-2.6-2.8-2.9-3.2-2.0-1.1
Weight adjusted by age1.92.84.5-2.0-1.6-1.9-2.0-2.1-1.7-2.1-1.6-1.6-1.30.9-0.6
Bone surface0.10.20.40.0-0.2-0.4-0.5-0.5-0.2-0.6-0.4-0.5-0.20.2-0.3
Bone volume0.10.20.5-0.3-0.0-0.6-0.6-0.7-0.3-0.7-0.5-0.4-0.30.6-0.3
Breakpoint value in progressive ratio session0.20.30.50.40.40.60.60.70.50.60.50.50.5-0.20.3
Number of licking bursts0.30.51.8-0.4-0.6-0.8-0.6-0.5-0.6-0.6-0.9-0.6-0.6-0.9-1.3
Context. condit. distance diff. score1.01.21.90.71.01.41.31.11.20.91.21.11.01.01.3
Locomotion velocity, session 10.91.01.9-0.50.1-1.2-1.1-1.4-0.9-1.2-1.2-1.0-0.80.4-1.3
Locomotion distance, session 10.91.21.7-1.1-1.0-1.3-1.3-1.3-1.3-1.1-1.1-1.0-1.1-0.2-0.8
Locomotion velocity, session 20.30.40.6-0.7-0.5-0.7-0.8-0.6-0.7-0.4-0.7-0.6-0.6-0.5-0.7
Locomotion distance, session 20.20.20.40.30.40.40.40.50.40.60.50.60.50.20.6
Locomotion velocity, session 32.73.15.9-1.7-0.8-2.1-2.0-2.4-1.7-2.2-1.7-1.6-1.71.3-0.9
Locomotion distance, session 30.91.02.0-1.00.0-1.2-1.0-1.4-0.9-1.2-1.0-0.8-0.91.2-0.7
Stereotopy head waving bouts, day 31.51.82.71.11.21.41.31.31.31.31.51.61.40.91.7
Stereotopy head waving duration, day 30.20.20.40.20.20.50.50.60.50.50.50.60.50.20.5
Locomotion velocity, session 73.43.85.0-2.2-1.5-2.2-2.0-2.2-2.1-2.0-2.1-2.0-2.0-0.0-1.8
Locomotion distance, session 70.10.10.5-0.6-0.0-0.3-0.2-0.4-0.2-0.3-0.2-0.1-0.20.7-0.0
Stereotopy head waving bouts, day 70.40.50.9-0.3-0.2-0.9-0.8-1.0-0.7-0.9-0.7-0.6-0.60.3-0.6
Stereotopy head waving duration, day 70.40.50.8-0.2-0.3-0.9-0.8-0.9-0.8-0.7-0.8-0.7-0.7-0.4-0.8
Locomotion velocity, session 81.11.42.5-1.6-0.4-1.2-1.3-1.5-0.9-1.4-1.1-0.9-1.01.5-0.3
Locomotion distance, session 80.91.32.20.71.11.31.21.11.21.11.31.31.10.91.5
Degree of sensitization distance0.50.51.20.50.10.90.81.10.70.90.80.70.7-0.50.5
Degree of sensitization stereotypy1.11.12.4-0.5-0.5-1.4-1.3-1.5-1.1-1.3-1.1-1.0-1.00.2-0.8
Conditioned locomotion0.50.61.1-0.1-0.2-0.8-0.8-1.0-0.6-1.1-0.9-0.9-0.70.0-1.0
Cocaine response after cond. corrected0.50.61.5-0.7-0.1-0.8-0.9-1.2-0.8-1.1-0.7-0.6-0.81.1-0.1
Cocaine response after cond. not corrected1.51.83.3-1.2-1.0-1.5-1.5-1.8-1.5-1.7-1.2-1.2-1.40.6-0.5
Cocaine response before conditioning0.40.51.5-0.4-1.2-0.7-0.7-0.6-0.7-0.7-0.5-0.7-0.5-0.6-0.3
Saline control response0.20.21.9-0.20.0-0.3-0.2-0.4-0.0-0.5-0.00.00.11.40.4
Bone: connectivity density0.10.10.20.40.10.30.20.40.40.40.20.20.3-0.5-0.0
Bone: cortical apparent density1.31.82.51.21.11.51.41.61.51.61.41.51.40.11.2
Bone: cortical area0.50.84.6-1.4-0.4-0.4-0.5-0.6-0.2-0.6-0.10.2-0.12.11.2
Bone: cortical porosity0.20.20.70.60.80.30.40.40.40.50.10.10.2-0.5-0.7
Bone: cortical porosity0.10.10.4-0.00.5-0.2-0.1-0.2-0.0-0.1-0.3-0.2-0.20.1-0.7
Bone: cortical thickness1.42.36.2-0.10.91.31.21.31.41.31.61.91.42.12.5
Bone: cortical thickness0.10.21.5-0.40.2-0.1-0.0-0.20.1-0.3-0.00.10.11.20.3
Bone: cortical tissue density1.11.52.01.11.01.41.31.41.41.41.31.31.30.11.0
Condit. Reinf. active minus inactive responses3.43.86.8-2.6-2.4-2.0-2.0-1.7-2.3-1.6-1.8-1.9-2.1-1.2-1.4
Condit. Reinf. active-inactive response ratio2.22.44.2-2.0-1.9-1.4-1.4-1.2-1.7-1.2-1.5-1.6-1.7-1.1-1.4
Condit. Reinf. active responses1.62.03.7-1.9-1.7-1.4-1.5-1.3-1.7-1.1-1.3-1.3-1.5-0.7-0.9
Condit. Reinf. inactive responses0.10.10.70.20.60.20.20.00.30.00.20.30.30.80.4
Incentive salience index mean1.51.82.9-1.7-1.6-1.4-1.4-1.1-1.7-0.9-1.2-1.3-1.5-1.2-1.0
Condit. Reinf. lever presses0.30.40.7-0.6-0.6-0.8-0.7-0.6-0.8-0.3-0.5-0.5-0.7-0.7-0.4
Condit. Reinf. active minus inactive responses0.00.00.20.30.0-0.2-0.1-0.3-0.0-0.3-0.0-0.1-0.00.40.2
Condit. Reinf. active-inactive response ratio0.10.10.60.80.30.20.20.10.2-0.00.20.10.20.10.2
Condit. Reinf. active responses0.20.30.5-0.5-0.5-0.6-0.7-0.7-0.5-0.7-0.3-0.3-0.40.60.3
Condit. Reinf. inactive responses1.72.34.9-2.2-1.5-1.7-1.7-1.7-1.5-1.6-1.3-1.2-1.50.9-0.3
Condit. Reinf. lever presses1.31.84.1-2.0-1.6-1.3-1.5-1.3-1.4-1.3-1.2-1.3-1.40.1-0.6
Condit. Reinf. lever reinforcers received0.40.50.9-0.7-0.6-0.8-0.9-0.9-0.7-1.0-0.6-0.6-0.60.70.0
Conditioned reinforcement - actives0.30.51.00.90.40.80.70.70.61.00.80.80.5-0.60.8
Conditioned reinforcement - inactives0.20.32.2-0.2-0.50.30.10.5-0.20.60.10.1-0.5-1.5-0.2
Conditioned locomotion0.40.51.9-0.6-1.4-0.7-0.7-0.4-0.8-0.3-0.3-0.4-0.7-0.90.2
Patch foraging indifference point 0 sec1.62.94.3-2.0-1.8-2.1-1.9-1.8-1.9-1.7-1.8-1.7-1.5-0.3-1.5
Patch foraging indifference point AUC3.14.56.9-2.1-2.6-2.3-2.3-2.1-2.5-1.9-2.1-2.1-2.4-1.2-1.4
Delay disc. indifference point, 0s delay0.40.40.90.60.90.60.60.30.40.50.60.70.51.00.8
Delay disc. indifference point, 16s delay0.20.20.8-0.10.6-0.00.30.20.30.50.40.60.30.90.5
Delay disc. indifference point, 2s delay0.91.01.6-0.6-0.8-1.0-1.1-1.1-1.3-1.0-1.1-1.1-1.2-0.5-1.0
Delay disc. indifference point, 24s delay0.10.10.30.50.20.10.30.40.10.60.40.50.5-0.30.2
Delay disc. indifference point, 4s delay0.10.10.60.2-0.10.20.20.30.10.50.50.30.1-0.20.8
Delay disc. indifference point, 8s delay1.51.83.11.81.51.11.41.31.11.51.41.41.50.31.0
Indifference point function ln k0.40.71.30.61.20.90.90.81.01.00.70.80.90.20.2
Indifference point function log k0.40.71.30.61.20.90.90.81.01.00.70.80.90.20.2
Patch foraging total patch changes 0 sec1.42.74.0-1.9-1.6-2.0-1.8-1.7-1.8-1.7-1.7-1.6-1.4-0.2-1.3
Patch foraging total patch changes 12 sec1.62.13.1-1.7-1.8-1.6-1.6-1.6-1.6-1.7-1.3-1.3-1.50.2-0.5
Patch foraging total patch changes 18 sec0.30.51.0-0.6-1.0-0.7-0.6-0.4-0.8-0.6-0.7-0.7-0.7-0.7-0.8
Patch foraging total patch changes 24 sec0.40.62.0-1.4-1.3-0.9-0.9-0.6-1.0-0.6-0.6-0.4-0.6-0.1-0.1
Patch foraging total patch changes 6 sec3.55.49.1-3.0-2.7-2.6-2.5-2.4-2.6-2.3-2.3-2.2-2.3-0.3-1.5
Patch foraging time to switch 0 sec2.34.75.72.12.22.32.22.02.31.92.42.22.41.52.3
Patch foraging water rate 0 sec0.20.51.0-1.0-0.6-0.8-0.8-0.7-0.8-0.5-0.7-0.5-0.8-0.1-0.5
Patch foraging water rate 12 sec0.40.81.3-1.0-0.4-0.9-0.9-1.0-0.8-0.9-1.1-0.9-1.10.0-1.0
Patch foraging water rate 18 sec0.10.20.6-0.4-0.20.50.50.80.40.60.20.30.2-0.7-0.2
Patch foraging water rate 24 sec0.10.20.5-0.1-0.00.60.30.60.50.60.20.20.3-0.7-0.1
Patch foraging water rate 6 sec0.30.40.80.10.60.70.60.80.80.90.70.90.60.20.6
Seeking ratio, delayed vs. immediate footshock0.81.02.70.60.41.01.01.00.71.11.31.21.00.41.7
Distance traveled before self-admin0.20.30.90.00.70.30.60.40.70.10.30.50.51.00.0
Distance traveled after self-admin0.40.51.4-0.10.30.70.71.00.71.20.60.70.7-0.30.3
Extensor digitorum longus weight0.31.25.3-1.2-2.3-0.8-0.9-0.2-1.1-0.2-0.6-0.7-0.9-1.9-0.3
Bone: elastic displacement0.20.20.40.40.40.60.50.60.60.60.50.50.5-0.20.3
Bone: elastic work0.50.72.7-0.70.20.60.50.60.60.70.81.00.61.21.6
Bone: endosteal estimation2.76.09.8-2.0-2.2-2.7-2.8-3.0-2.5-3.1-2.6-2.7-2.40.2-1.8
Bone: endosteal perimeter0.91.93.1-1.4-1.6-1.5-1.6-1.6-1.5-1.8-1.4-1.4-1.30.1-0.6
Epididymis fat weight0.20.53.7-1.2-1.90.2-0.30.4-0.20.00.2-0.2-0.1-0.90.6
Delta time in closed arm before/after self-admin0.20.21.2-0.2-1.1-0.4-0.4-0.2-0.4-0.5-0.1-0.2-0.1-0.30.3
Delta time in open arm before/after self-admin2.52.53.4-1.9-1.3-1.7-1.6-1.6-1.8-1.4-1.7-1.7-1.8-0.5-1.4
Diff in mean of infusions in LGA sessions0.10.10.4-0.30.30.10.20.20.20.20.20.50.40.60.6
Delay discount exponential model param0.30.30.6-0.7-0.6-0.4-0.6-0.5-0.3-0.8-0.7-0.7-0.6-0.0-0.6
Extinction: sum of active levers before priming1.31.43.0-1.4-1.7-0.9-1.0-0.6-1.3-0.4-1.1-1.2-1.0-1.6-1.4
Active lever presses in extinction session 60.20.20.9-0.9-0.7-0.3-0.4-0.0-0.40.2-0.4-0.2-0.2-0.7-0.2
Bone: final force0.20.30.7-0.8-0.8-0.4-0.6-0.6-0.5-0.6-0.3-0.3-0.40.50.4
Bone: final moment0.20.40.9-0.9-0.8-0.6-0.7-0.7-0.6-0.7-0.4-0.3-0.50.60.4
Food consumed during 24 hour testing period0.10.20.7-0.5-0.10.30.10.20.30.20.40.30.40.80.8
Glucose0.50.71.4-1.0-1.0-0.7-0.8-0.8-0.6-1.2-0.9-1.0-0.80.3-0.6
Heart weight0.30.40.6-0.7-0.7-0.5-0.7-0.6-0.6-0.7-0.7-0.7-0.7-0.5-0.7
Delay discount hyperbolic model param0.20.20.5-0.7-0.4-0.4-0.5-0.5-0.2-0.7-0.5-0.5-0.40.3-0.4
Intermittent access intake day 1-15 change0.40.91.61.01.30.90.90.80.81.21.01.20.80.41.0
Intermittent access intake escalation0.40.81.50.91.21.00.90.90.81.20.91.00.60.10.8
Intermittent access intake escalation 20.30.30.80.60.90.60.70.50.50.60.40.60.40.20.1
Intermitt. access day 1 inactive lever presses0.10.31.1-0.00.30.70.60.70.11.10.60.60.2-0.30.5
Intermitt. access day 15 inactive lever presses0.10.20.8-0.00.00.50.30.50.10.70.10.1-0.1-0.9-0.5
Intermitt. access escalation Index0.30.42.00.30.10.20.1-0.10.3-0.20.50.50.51.31.4
Intermittent access day 1 total infusions0.61.01.91.10.51.21.21.41.01.20.80.70.9-1.1-0.1
Intermittent access day 15 total infusions0.81.11.91.21.11.21.21.31.11.41.01.10.9-0.50.5
Intermittent access terminal intake (last 3 days)0.60.81.71.30.81.11.01.10.91.00.70.70.7-0.8-0.0
Intermittent access total infusions0.91.01.71.30.71.21.11.31.11.20.80.80.8-1.10.0
Intermittent access day 1 locomotion1.11.47.0-0.4-1.4-0.5-0.60.0-0.9-0.2-0.9-1.1-1.1-2.6-1.8
Intermittent access day 15 total locomotion0.50.94.7-0.1-1.0-0.6-0.4-0.0-0.80.1-0.7-0.8-1.0-2.2-1.4
Intermittent access total locomotion0.91.06.0-0.0-1.0-0.5-0.40.0-0.80.1-0.7-0.8-1.0-2.5-1.5
Intermittent access standard deviation1.22.54.50.91.31.61.82.01.62.11.71.91.30.11.5
Left kidney weight0.21.05.80.9-0.91.00.61.30.50.80.70.30.5-2.40.2
Right kidney weight0.21.18.80.6-1.00.70.41.00.30.50.1-0.40.1-3.0-1.0
Cocaine induced anxiety0.20.31.30.10.10.40.50.60.30.70.70.70.40.21.1
Post-drug Anxiety0.30.31.9-0.40.6-0.20.1-0.10.20.10.30.60.21.41.1
Baseline Anxiety0.30.31.0-0.80.3-0.6-0.5-0.7-0.2-0.6-0.7-0.3-0.21.0-0.4
Tail length0.83.06.2-2.5-2.5-1.9-2.0-1.7-2.0-1.5-1.5-1.4-1.7-0.3-0.4
Length with tail0.94.110.3-3.0-3.2-2.1-2.3-1.8-2.3-1.7-1.6-1.5-1.9-0.4-0.1
Length without tail0.51.64.9-1.7-2.2-1.1-1.2-0.8-1.3-0.6-1.1-1.1-1.1-1.3-0.7
Times rat made contact with spout0.30.41.70.70.00.50.50.80.40.70.30.30.6-1.3-0.4
Lifetime Intake0.91.12.01.10.41.21.11.41.01.30.80.80.7-1.4-0.0
Liver weight, left0.30.44.00.6-0.60.0-0.30.1-0.30.2-0.1-0.3-0.1-2.0-0.3
Liver weight, right0.81.53.6-1.2-1.9-1.1-1.2-0.9-1.3-1.0-1.2-1.3-1.1-1.2-1.0
Locomotor activity0.40.61.70.40.80.40.50.20.60.40.80.90.81.31.1
Locomotor testing distance0.40.71.70.31.00.60.70.50.80.70.81.01.01.31.0
Locomotor testing rearing0.20.52.10.41.30.40.50.10.80.00.30.50.81.50.1
Locomotion in novel chamber2.73.44.91.41.52.21.81.92.21.82.12.02.00.82.2
Locomotion in novel chamber post-restriction0.30.61.20.80.30.80.50.70.80.80.90.80.9-0.21.1
Fecal boli incidents, locomotor time 10.50.72.91.71.70.50.70.30.70.20.30.30.60.2-0.7
Change in fecal boli incidents, locomotor task1.81.83.01.30.81.51.41.61.31.71.51.41.2-0.41.3
Time >=10cm from walls, locomotor time 10.20.21.1-0.40.4-0.4-0.1-0.3-0.2-0.10.10.2-0.01.00.5
Bouts of movement, locomotor time 10.10.10.30.40.60.20.20.10.30.20.20.20.50.2-0.2
Total resting periods, locomotor time 10.10.10.30.30.60.10.20.10.20.20.20.20.30.3-0.1
Rest time, locomotor task time 10.30.40.80.50.7-0.7-0.3-0.8-0.3-0.6-0.5-0.4-0.20.7-0.9
Distance moved, locomotor task time 10.30.51.00.2-0.20.90.61.00.50.90.70.40.3-1.00.7
Vertical activity count, locomotor time 10.00.10.30.1-0.30.40.20.40.00.20.30.00.1-0.60.4
Time >=10cm from walls, locomotor time 20.81.13.4-0.70.1-1.2-1.1-1.6-0.7-1.5-0.9-0.7-0.71.8-0.2
Bouts of movement, locomotor time 20.40.61.4-0.0-0.2-0.8-0.7-0.7-0.8-0.5-0.8-0.8-0.7-1.1-1.2
Total resting periods, locomotor time 20.50.81.6-0.0-0.4-1.1-0.9-0.9-1.0-0.7-1.0-0.9-0.8-1.1-1.3
Rest time, locomotor task time 20.20.30.80.1-0.1-0.9-0.6-0.7-0.5-0.5-0.5-0.5-0.3-0.2-0.6
Distance moved, locomotor task time 20.10.10.3-0.6-0.2-0.2-0.3-0.3-0.5-0.2-0.1-0.2-0.50.20.3
Vertical activity count, locomotor time 20.00.00.10.30.30.20.10.00.1-0.30.1-0.10.00.30.0
Light reinforcement 10.61.62.6-1.0-1.2-1.6-1.6-1.6-1.3-1.2-1.4-1.1-1.2-0.3-1.1
Light reinforcement 20.30.43.50.7-0.7-0.3-0.30.0-0.40.3-0.1-0.2-0.1-1.9-0.4
Bone: marrow area2.55.59.2-1.8-2.0-2.6-2.7-2.9-2.4-3.0-2.5-2.6-2.30.3-1.7
Bone: maximum diameter1.01.93.2-1.8-1.1-1.6-1.6-1.8-1.3-1.7-1.2-1.0-1.11.4-0.1
Bone: maximum force0.20.41.0-1.0-0.8-0.6-0.7-0.7-0.5-0.7-0.3-0.3-0.30.90.5
Bone: maximum moment0.30.51.2-1.1-0.9-0.8-0.8-0.8-0.7-0.8-0.4-0.4-0.50.90.5
Mean time between licks in bursts1.74.18.32.92.32.22.01.82.31.62.01.72.20.91.7
Mean num. licks in bursts0.50.71.10.90.61.10.80.90.80.91.00.70.90.01.0
Cd content in liver0.10.10.70.10.0-0.1-0.2-0.3-0.0-0.40.0-0.1-0.10.80.4
Co content in liver1.41.64.02.01.51.41.41.31.31.40.70.71.0-1.1-0.6
Cu content in liver0.20.20.60.30.30.40.50.60.40.80.50.60.4-0.20.3
Fe content in liver3.64.36.1-1.7-2.5-2.2-2.0-1.6-2.2-1.5-2.2-2.2-2.0-2.3-2.4
K content in liver0.20.20.50.50.50.40.50.40.30.60.10.10.2-0.7-0.5
Mg content in liver0.40.41.20.80.70.50.70.60.40.6-0.00.00.2-1.0-1.1
Mn content in liver0.30.31.20.61.10.50.60.40.50.70.30.50.20.0-0.2
Na content in liver7.27.811.1-2.2-2.4-2.8-2.9-2.9-2.9-2.7-3.1-3.1-2.9-1.7-3.3
Rb content in liver0.10.10.20.40.40.30.40.30.30.40.20.30.3-0.00.1
Se content in liver2.53.04.01.91.71.71.71.71.82.01.81.92.00.31.5
Sr content in liver3.63.14.11.82.02.02.01.91.92.01.81.91.80.41.2
Zn content in liver0.30.30.80.10.60.50.60.40.60.50.60.60.60.90.6
Bone: minimum diameter2.74.97.5-2.7-2.1-2.4-2.5-2.7-2.2-2.7-2.1-2.0-2.11.4-0.7
Time in familiar zone, hab. session 11.21.11.60.60.61.11.11.31.11.31.21.31.20.31.2
Time in novel zone, hab. session 10.50.51.0-0.5-0.7-0.9-0.9-1.0-0.8-1.0-0.7-0.7-0.70.3-0.2
Total zone transitions, hab. session 11.92.64.3-2.1-1.2-2.0-1.8-2.1-1.6-1.9-1.4-1.3-1.61.3-0.4
Total locomotion distance, hab. session 10.30.41.7-0.4-0.3-0.6-0.5-0.6-0.4-0.50.00.2-0.21.31.1
Locomotion velocity, hab. session 10.20.21.2-0.1-0.0-0.2-0.1-0.2-0.1-0.10.30.40.11.11.1
Time in familiar zone, hab. session 21.01.11.50.81.21.01.00.81.00.91.11.11.01.21.2
Time in novel zone, hab. session 21.01.01.5-0.8-1.2-0.8-1.0-0.7-0.9-0.8-1.0-1.1-1.0-1.2-1.1
Total zone transitions, hab. session 20.91.12.5-1.6-1.2-1.3-1.2-1.2-1.1-1.1-0.8-0.7-0.90.80.1
Total locomotion distance, hab. session 20.50.73.00.20.20.50.50.50.50.61.01.00.71.01.7
Locomotion velocity, hab. session 20.40.52.60.20.10.40.40.40.40.50.90.90.60.81.6
Novel to familiar place preference ratio0.40.40.91.00.70.60.70.70.70.60.60.50.6-0.10.3
Novelty place preference0.60.61.21.10.80.80.90.80.90.70.90.80.80.20.6
Time in novel zone, NPP test0.40.50.80.90.60.70.80.70.80.60.70.60.60.20.5
Total zone transitions, NPP test0.81.22.2-1.5-1.0-1.3-1.3-1.3-1.1-1.2-1.1-1.0-1.00.5-0.4
Total locomotion distance, NPP test1.01.42.31.30.91.21.11.11.11.21.31.31.30.41.5
Locomotion velocity, NPP test1.11.52.21.51.11.11.11.11.11.31.41.41.40.31.5
Intraocular pressure0.00.00.2-0.4-0.3-0.00.00.20.1-0.0-0.1-0.2-0.1-0.1-0.4
Delta distance traveled before/after self-admin0.50.62.4-0.7-1.4-0.4-0.7-0.2-0.80.3-0.3-0.5-0.5-1.5-0.2
Delta ambulatory time before/after self-admin0.50.64.0-0.5-1.3-0.2-0.50.2-0.70.6-0.2-0.5-0.5-2.0-0.3
Parametrial fat weight1.43.311.8-2.5-3.4-1.6-1.9-1.2-2.1-1.1-1.3-1.5-1.6-1.5-0.1
Pavlov. Cond. lever latency0.30.40.80.40.20.90.70.80.70.50.60.40.60.20.6
Pavlov. Cond. magazine entry latency1.01.32.80.81.70.80.90.50.90.81.11.31.11.61.3
Pavlov. Cond. change in total contacts0.30.30.50.60.70.30.40.30.40.60.60.70.60.20.6
Pavlov. Cond. index score0.40.51.50.51.20.30.50.20.50.50.70.90.61.10.9
Pavlov. Cond. latency score0.40.51.40.61.20.30.40.10.40.40.60.80.61.10.8
Pavlov. Cond. lever contacts0.10.10.3-0.20.2-0.5-0.4-0.6-0.3-0.2-0.20.0-0.10.50.1
Pavlov. Cond. magazine entry number0.60.71.7-0.6-1.3-0.5-0.7-0.3-0.6-0.6-0.8-1.0-0.8-1.3-1.0
Pavlov. Cond. intertrial magazine entries0.10.20.4-0.4-0.3-0.3-0.3-0.4-0.3-0.7-0.4-0.5-0.30.4-0.3
Pavlov. Cond. lever-magazine prob. diff.0.60.81.80.71.30.60.70.40.70.80.91.10.81.01.0
Pavlov. Cond. response bias0.10.20.60.10.70.00.2-0.10.10.30.40.50.30.80.5
Pavlov. Cond. lever latency0.50.72.01.30.50.80.80.90.60.90.50.40.7-1.4-0.3
Pavlov. Cond. magazine entry latency5.06.08.4-2.6-2.2-2.8-2.8-2.9-2.6-2.8-2.5-2.4-2.60.4-1.4
Pavlov. Cond. change in total contacts0.61.02.8-1.7-0.7-0.9-0.9-1.0-0.9-1.0-0.7-0.6-1.01.30.2
Pavlov. Cond. index score1.31.73.5-1.9-1.0-1.4-1.4-1.5-1.3-1.5-1.1-1.1-1.31.3-0.2
Pavlov. Cond. latency score1.21.63.0-1.7-1.0-1.4-1.4-1.5-1.3-1.5-1.2-1.2-1.30.9-0.4
Pavlov. Cond. lever contacts0.40.62.2-1.3-0.4-0.6-0.6-0.7-0.5-0.7-0.4-0.3-0.61.50.4
Pavlov. Cond. magazine entry number1.11.42.41.30.71.31.31.51.11.51.11.11.2-1.20.3
Pavlov. Cond. intertrial magazine entries1.11.63.01.10.91.51.61.71.41.51.31.31.3-0.20.6
Pavlov. Cond. lever-magazine prob. diff.1.31.73.5-1.9-1.0-1.4-1.4-1.5-1.3-1.5-1.1-1.0-1.31.4-0.1
Pavlov. Cond. response bias1.11.64.0-1.8-0.8-1.3-1.2-1.4-1.1-1.4-0.8-0.7-1.12.00.4
Time in closed arm before self-admin0.10.10.2-0.40.3-0.1-0.2-0.3-0.1-0.1-0.2-0.2-0.50.4-0.0
Time in closed arm after self-admin0.20.20.9-0.0-0.00.50.30.40.40.20.50.40.30.41.0
Time in open arm before self-admin0.50.61.00.70.60.60.70.70.80.60.80.91.00.70.9
Time in open arm after self-admin0.50.61.2-1.1-0.5-1.0-0.8-0.8-1.0-0.5-0.8-0.7-0.80.0-0.5
Bone: periosteal estimation1.63.45.8-2.2-1.7-2.0-2.1-2.3-1.8-2.4-1.7-1.6-1.61.5-0.3
Bone: periosteal perimeter1.42.44.4-2.1-1.5-1.7-1.7-1.9-1.4-2.0-1.3-1.2-1.21.70.1
Bone: post-yield work3.04.46.2-2.3-1.9-2.4-2.4-2.5-2.2-2.4-2.1-2.1-2.10.4-1.3
Progressive ratio test 1 active lever presses0.50.64.7-0.2-1.00.1-0.10.6-0.20.6-0.2-0.3-0.4-2.2-0.8
Progressive ratio test 1 breakpoint0.50.64.8-0.2-1.10.1-0.10.6-0.30.6-0.1-0.3-0.4-2.2-0.7
Progressive ratio test 1 inactive lever presses0.50.84.90.1-0.60.90.41.10.31.20.30.00.1-2.2-0.5
Progressive ratio test 2 active lever presses0.50.63.10.80.40.60.40.80.31.20.40.30.2-1.8-0.4
Progressive ratio test 2 breakpoint0.50.63.10.80.60.60.50.80.41.20.40.30.2-1.8-0.5
Progressive ratio test 2 inactive lever presses1.01.63.91.01.11.51.31.71.12.01.31.30.9-1.10.7
Incentive Sensitization - Responses0.71.02.11.31.20.90.91.10.81.50.80.80.6-1.2-0.1
Incentive Sensitization - Breakpoint1.01.32.51.61.51.11.11.21.01.60.90.90.8-1.1-0.0
Sum of active levers in priming session hrs 5-60.10.10.40.0-0.4-0.0-0.00.1-0.20.1-0.0-0.20.1-0.6-0.1
Progressive ratio0.81.33.4-0.7-0.6-1.1-1.0-1.0-1.0-1.1-1.4-1.4-1.2-0.8-1.9
Food seeking constrained by brief footshock0.40.51.7-0.6-0.5-0.1-0.3-0.0-0.2-0.2-0.7-0.9-0.8-1.2-1.3
Seeking ratio, punishment vs. effort0.40.61.20.10.20.90.70.80.70.80.90.80.70.51.1
Retroperitoneal fat weight0.31.36.2-2.0-2.5-0.5-1.0-0.0-1.00.0-0.4-0.6-0.7-1.70.3
Reaction time number correct2.44.68.7-2.3-2.9-2.0-2.1-1.6-2.3-1.5-2.2-2.2-1.8-2.4-2.1
Reaction time mean minus median0.10.31.70.40.1-0.10.1-0.1-0.10.10.60.50.20.81.3
Reaction time mean minus median AUC0.00.10.30.1-0.5-0.4-0.2-0.3-0.4-0.30.1-0.1-0.10.00.6
Reaction time num false alarms3.65.07.01.91.62.42.32.32.32.42.52.52.41.02.7
Reaction time num false alarms AUC3.35.17.12.01.52.42.42.52.32.52.52.62.30.72.7
Reaction time trials correct on left2.44.68.7-2.3-2.9-2.0-2.1-1.6-2.3-1.5-2.2-2.2-1.8-2.4-2.1
Reaction time trials on left2.34.48.2-2.2-2.9-2.0-2.0-1.6-2.2-1.4-2.1-2.1-1.8-2.3-2.1
Reaction time mean1.11.73.51.91.41.41.51.21.21.11.51.21.10.51.2
Reaction time mean AUC0.91.43.51.91.31.31.41.21.11.01.30.90.9-0.00.8
Median of all reaction times1.62.35.12.21.71.81.81.61.61.31.61.31.30.10.9
Reaction time omissions0.40.62.31.51.20.80.70.40.90.40.60.50.70.10.0
Reaction time false alarm rate7.09.612.12.92.83.33.23.13.23.13.43.53.11.63.5
Reaction time premature initiation rate0.30.42.3-0.11.00.30.30.10.40.30.40.70.41.50.7
Reaction time premature initiations0.20.41.2-1.1-0.4-0.7-0.7-0.7-0.7-0.5-0.7-0.4-0.50.3-0.4
Std. dev. reaction times0.50.91.91.21.00.80.90.70.70.71.21.00.70.81.4
Reaction time trials completed2.34.48.2-2.2-2.9-2.0-2.0-1.6-2.2-1.4-2.1-2.1-1.8-2.3-2.1
Reaction time trials AUC2.03.87.2-2.1-2.7-1.9-1.9-1.4-2.1-1.3-2.0-2.0-1.7-2.2-2.0
Run reversals in cocaine runway, females0.10.10.30.1-0.10.30.30.30.1-0.10.40.20.10.10.5
Run reversals in cocaine runway, males1.21.23.2-1.4-1.5-0.8-0.9-0.5-1.0-0.2-0.9-1.1-0.9-1.8-1.3
Latency to leave start box in cocaine runway0.91.04.50.80.30.60.40.30.70.41.11.11.11.42.1
Latency to leave start box in cocaine runway, F0.30.41.00.60.40.50.40.30.70.20.60.60.80.91.0
Latency to leave start box in cocaine runway, M0.70.74.40.4-0.10.20.1-0.10.20.30.80.90.61.32.1
Std. dev. time between licks in bursts0.20.31.11.00.60.70.60.60.80.30.30.10.6-0.1-0.2
Total sessions with >9 infusions0.91.11.91.20.41.31.11.41.01.20.90.80.8-1.20.2
Short access day 1 total inactive lever presses0.10.21.50.00.00.10.20.3-0.20.10.0-0.1-0.4-1.2-0.5
Short access day 10 total inactive lever presses0.30.71.7-1.3-0.9-0.7-0.8-0.5-0.9-0.6-0.8-0.8-1.2-0.6-0.8
Short access day 1 total infusions0.70.91.90.70.31.31.11.41.11.01.11.00.7-0.60.8
Short access day 10 total infusions1.52.03.31.50.91.71.61.81.51.81.41.31.3-0.80.6
Short access total infusions0.40.51.80.6-0.10.80.71.00.60.80.50.40.4-1.3-0.2
Short access day 1 locomotion0.50.63.1-0.8-1.8-0.4-0.7-0.3-0.8-0.4-0.2-0.4-0.8-1.00.4
Short access day 10 total locomotion0.10.30.70.50.10.50.70.80.40.70.50.40.2-0.8-0.1
Short access total locomotion0.50.64.30.1-0.90.30.20.7-0.20.50.0-0.2-0.4-2.1-0.6
One hour access (0.3 mA shock)0.91.01.81.31.01.11.11.01.01.01.11.20.8-0.20.9
Compulsive drug intake0.81.02.0-0.8-0.2-1.4-1.1-1.4-0.9-1.3-1.0-0.7-0.81.1-0.4
One hour access (shock baseline)0.81.32.11.10.81.41.21.31.21.21.31.21.0-0.11.1
Social response proportion0.50.50.80.70.70.80.80.90.50.80.90.60.6-0.50.6
Social responses0.50.71.8-1.3-0.5-0.9-0.9-1.0-0.9-0.9-0.6-0.6-0.90.90.1
Social time0.20.30.6-0.40.1-0.6-0.6-0.7-0.4-0.7-0.5-0.4-0.70.6-0.2
Soleus weight0.10.21.3-0.7-1.1-0.1-0.30.1-0.40.20.10.1-0.0-0.60.5
Bone: stiffness0.10.10.30.30.00.40.30.30.20.40.40.40.40.00.5
Tibialis anterior weight0.51.83.20.5-0.01.61.41.81.31.61.61.51.3-0.01.8
Time to tail flick, vehicle, before self-admin0.50.62.00.60.40.70.50.70.60.7-0.1-0.20.2-1.4-1.4
Time to tail flick, vehicle, after self-admin1.21.62.8-1.7-1.3-1.5-1.3-1.4-1.6-1.3-1.0-1.0-1.50.3-0.4
Time to tail flick, test, before self-admin0.20.20.4-0.0-0.4-0.1-0.6-0.4-0.2-0.5-0.5-0.6-0.4-0.3-0.4
Time to tail flick, test, after self-admin0.20.21.40.40.0-0.1-0.00.0-0.40.1-0.2-0.3-0.3-1.2-0.7
Delta time to tail flick, vehicle, before/after SA0.80.71.5-1.2-1.1-1.0-0.8-0.9-1.2-0.7-0.3-0.3-0.80.70.7
Delta time to tail flick, test, before/after SA0.10.10.4-0.0-0.1-0.5-0.2-0.4-0.6-0.4-0.1-0.1-0.3-0.0-0.0
Tibia length4.612.816.8-4.1-3.6-3.9-3.9-3.9-3.9-3.9-3.6-3.6-3.8-0.4-2.5
Ambulatory time before self-admin0.10.20.6-0.00.50.30.50.30.6-0.10.20.40.50.80.0
Ambulatory time after self-admin0.10.20.7-0.5-0.50.20.10.50.10.70.20.20.2-0.80.0
Bone: tissue strength0.50.51.20.40.10.70.60.90.51.00.60.70.6-1.10.3
Total heroin consumption0.30.41.10.30.00.60.71.00.21.00.60.50.4-1.00.1
Bone: trabecular number0.40.71.21.11.00.90.91.01.01.00.70.80.9-0.50.1
Bone: trabecular spacing3.04.04.8-1.8-2.0-2.2-2.2-2.2-2.2-2.1-2.2-2.1-2.0-0.7-1.8
Bone: trabecular thickness0.10.10.8-0.40.1-0.3-0.2-0.3-0.0-0.4-0.1-0.0-0.10.90.2
Bone: trabecular tissue density0.20.31.3-0.00.70.40.40.20.50.20.40.40.41.10.5
Water consumed over 24 hours0.20.20.60.10.10.50.50.80.50.60.40.40.6-0.20.2
Number of responses in last shaping day0.30.31.60.3-0.50.70.30.80.30.50.50.20.1-1.30.3