Hyls1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Hyls1	0.48	0.15	2.6e-10	-0	0.06	0.06	0.05	5.8e-01	1.3e-07	1.1e-07	1.5e-06
2	Liver	mRNA stability	Hyls1	0.22	0.12	1.0e-03	0	0.02	0.02	0	1.1e-01	2.5e-03	6.3e-03	2.7e-01
3	Adipose	gene expression	Hyls1	0.48	0.14	2.4e-10	0	0.07	0.07	0.05	1.3e-01	3.0e-08	7.7e-08	1.4e-06
4	LHb	mRNA stability	Hyls1	0.22	0.16	5.0e-04	0.12	0.14	0.12	0.14	7.8e-04	3.7e-04	1.0e-03	3.5e-04
5	LHb	gene expression	Hyls1	0.12	0.1	9.7e-03	0.07	0.1	0.07	0.1	1.1e-02	3.0e-03	8.2e-03	2.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.5	0.8	1.8	0.9	-1.1	-1.3	0.0	0.0
Area under the delay curve	0.0	0.0	0.1	0.0	0.3	-0.1	0.0	0.0
BMI with tail	0.6	1.9	2.8	1.2	-1.7	-0.5	-1.6	-1.6
BMI without tail	2.2	4.4	10.4	3.2	-2.6	-0.7	-1.5	-1.5
Body weight	0.9	3.9	6.1	2.2	-2.5	0.2	-2.1	-2.1
Weight adjusted by age	0.2	0.2	0.5	0.2	-0.3	0.3	-0.7	-0.7
Bone surface	0.9	1.6	3.8	1.2	-1.7	-2.0	-0.3	-0.3
Bone volume	0.4	0.7	1.7	0.8	-1.2	-1.3	-0.1	-0.1
Breakpoint value in progressive ratio session	3.8	4.2	6.6	-1.8	1.8	-1.1	2.6	2.6
Number of licking bursts	0.2	0.3	0.5	-0.4	0.5	-0.3	0.7	0.7
Context. condit. distance diff. score	0.1	0.1	0.1	-0.2	0.3	-0.2	0.4	0.4
Locomotion velocity, session 1	0.4	0.5	0.9	0.5	-0.3	0.4	-0.9	-0.9
Locomotion distance, session 1	0.3	0.4	0.6	0.8	-0.6	0.2	-0.7	-0.7
Locomotion velocity, session 2	1.3	1.6	2.4	1.4	-0.9	0.6	-1.5	-1.5
Locomotion distance, session 2	0.4	0.5	1.3	1.1	-0.6	0.2	-0.7	-0.7
Locomotion velocity, session 3	0.2	0.2	0.3	0.4	-0.4	-0.5	-0.5	-0.5
Locomotion distance, session 3	1.7	1.9	3.4	0.8	-1.1	0.8	-1.9	-1.9
Stereotopy head waving bouts, day 3	2.5	3.0	4.7	-1.2	1.2	-1.7	2.2	2.2
Stereotopy head waving duration, day 3	1.5	1.8	2.9	-0.8	1.2	-1.1	1.7	1.7
Locomotion velocity, session 7	0.5	0.6	0.8	-0.5	0.6	-0.9	0.9	0.9
Locomotion distance, session 7	0.1	0.2	0.3	-0.6	0.5	0.4	0.1	0.1
Stereotopy head waving bouts, day 7	0.3	0.3	0.9	0.1	0.2	-1.0	0.6	0.6
Stereotopy head waving duration, day 7	0.4	0.4	1.8	0.3	-0.1	-1.3	0.4	0.4
Locomotion velocity, session 8	0.3	0.4	0.7	0.7	-0.8	-0.4	-0.6	-0.6
Locomotion distance, session 8	0.3	0.4	0.9	0.9	-0.7	-0.2	-0.5	-0.5
Degree of sensitization distance	0.7	0.7	1.2	-0.6	0.7	-0.3	1.1	1.1
Degree of sensitization stereotypy	0.4	0.5	0.8	0.7	-0.8	-0.9	-0.4	-0.4
Conditioned locomotion	0.9	1.0	1.3	0.8	-0.9	1.0	-1.1	-1.1
Cocaine response after cond. corrected	0.3	0.4	0.6	-0.7	0.8	0.6	0.4	0.4
Cocaine response after cond. not corrected	1.0	1.1	1.4	-1.2	1.2	0.1	1.1	1.1
Cocaine response before conditioning	1.4	1.7	2.5	-1.1	0.8	-1.2	1.6	1.6
Saline control response	1.2	1.6	6.1	-0.3	0.5	2.5	-0.8	-0.8
Bone: connectivity density	0.9	1.3	2.5	1.4	-1.6	-1.3	-0.4	-0.4
Bone: cortical apparent density	2.3	3.0	6.0	1.7	-2.4	-1.6	-1.4	-1.4
Bone: cortical area	5.2	7.9	18.2	2.5	-3.8	-4.3	-0.5	-0.5
Bone: cortical porosity	2.0	2.2	7.1	1.0	-1.6	-2.7	0.5	0.5
Bone: cortical porosity	1.9	2.0	6.8	0.6	-1.2	-2.6	0.9	0.9
Bone: cortical thickness	3.2	5.3	11.7	2.1	-3.2	-3.4	-0.5	-0.5
Bone: cortical thickness	3.4	3.9	9.4	1.5	-2.7	-3.1	-0.6	-0.6
Bone: cortical tissue density	2.2	2.8	5.6	1.6	-2.4	-1.5	-1.4	-1.4
Condit. Reinf. active minus inactive responses	0.4	0.4	0.8	-0.5	0.9	0.3	0.7	0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	-0.1	0.6	0.1	0.4	0.4
Condit. Reinf. active responses	0.2	0.3	0.5	-0.4	0.7	0.4	0.6	0.6
Condit. Reinf. inactive responses	0.1	0.2	0.7	-0.1	0.0	0.8	-0.3	-0.3
Incentive salience index mean	0.1	0.2	0.3	-0.3	0.4	0.1	0.5	0.5
Condit. Reinf. lever presses	0.0	0.0	0.1	0.2	-0.3	-0.1	0.1	0.1
Condit. Reinf. active minus inactive responses	1.7	2.1	2.9	-1.7	1.5	0.3	1.6	1.6
Condit. Reinf. active-inactive response ratio	1.7	1.8	2.6	-1.5	1.1	-0.5	1.6	1.6
Condit. Reinf. active responses	1.3	1.8	2.4	-1.6	1.5	1.1	1.2	1.2
Condit. Reinf. inactive responses	0.8	1.0	4.1	-0.0	0.4	2.0	-0.6	-0.6
Condit. Reinf. lever presses	0.3	0.3	0.7	-0.9	0.5	0.4	0.6	0.6
Condit. Reinf. lever reinforcers received	1.1	1.5	2.1	-1.4	1.2	0.8	1.3	1.3
Conditioned reinforcement - actives	0.7	0.7	1.5	-0.4	0.4	-0.4	1.2	1.2
Conditioned reinforcement - inactives	0.6	0.7	2.4	1.6	-0.6	-0.7	0.2	0.2
Conditioned locomotion	0.6	0.7	1.2	0.5	0.4	-0.8	1.1	1.1
Patch foraging indifference point 0 sec	1.9	3.1	4.7	2.2	-2.2	0.1	-1.7	-1.7
Patch foraging indifference point AUC	0.9	1.0	2.2	0.9	-1.5	-0.6	-1.0	-1.0
Delay disc. indifference point, 0s delay	0.9	1.0	1.6	0.7	-0.8	0.6	-1.3	-1.3
Delay disc. indifference point, 16s delay	1.5	1.5	1.9	-1.2	1.4	-0.5	1.4	1.4
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	0.0	-0.1	-0.1	0.0	0.0
Delay disc. indifference point, 24s delay	0.7	0.7	1.0	-0.8	0.8	-0.4	1.0	1.0
Delay disc. indifference point, 4s delay	0.8	0.9	1.4	0.7	-0.8	0.6	-1.2	-1.2
Delay disc. indifference point, 8s delay	0.2	0.3	0.9	0.9	-0.2	-0.1	-0.4	-0.4
Indifference point function ln k	0.5	0.7	1.8	1.3	-0.9	-0.3	-0.7	-0.7
Indifference point function log k	0.5	0.7	1.8	1.3	-0.9	-0.3	-0.7	-0.7
Patch foraging total patch changes 0 sec	2.0	3.1	4.9	2.2	-2.2	0.2	-1.7	-1.7
Patch foraging total patch changes 12 sec	0.9	1.2	1.4	1.2	-1.0	0.7	-1.2	-1.2
Patch foraging total patch changes 18 sec	0.1	0.1	0.2	0.3	-0.3	0.5	-0.1	-0.1
Patch foraging total patch changes 24 sec	0.4	0.4	0.8	0.6	-0.3	0.4	-0.9	-0.9
Patch foraging total patch changes 6 sec	2.1	3.1	4.7	1.4	-1.9	0.9	-2.2	-2.2
Patch foraging time to switch 0 sec	1.9	3.0	5.0	-2.2	1.8	-0.3	1.8	1.8
Patch foraging water rate 0 sec	1.2	1.9	4.0	2.0	-1.5	0.2	-1.3	-1.3
Patch foraging water rate 12 sec	1.3	2.0	5.6	0.5	0.6	2.4	-1.4	-1.4
Patch foraging water rate 18 sec	0.2	0.2	0.4	0.3	0.2	0.6	-0.5	-0.5
Patch foraging water rate 24 sec	0.7	1.0	1.8	1.4	-0.8	0.4	-1.1	-1.1
Patch foraging water rate 6 sec	0.9	1.3	3.1	0.9	0.5	1.8	-1.0	-1.0
Seeking ratio, delayed vs. immediate footshock	0.0	0.1	0.2	-0.5	0.1	0.2	-0.0	-0.0
Distance traveled before self-admin	0.8	0.8	3.0	-1.7	0.8	0.6	-0.2	-0.2
Distance traveled after self-admin	0.7	0.7	1.3	-0.5	0.1	0.9	-1.1	-1.1
Extensor digitorum longus weight	2.0	7.8	14.8	-2.9	3.8	1.5	2.6	2.6
Bone: elastic displacement	0.6	0.6	1.8	-0.0	0.8	1.3	-0.6	-0.6
Bone: elastic work	2.1	2.7	10.2	0.9	-1.5	-3.2	0.3	0.3
Bone: endosteal estimation	0.4	0.8	2.5	0.6	-1.1	-1.6	-0.2	-0.2
Bone: endosteal perimeter	0.6	1.2	2.2	1.2	-1.5	-0.3	-1.0	-1.0
Epididymis fat weight	1.0	2.3	4.8	2.2	-1.7	-0.1	-1.4	-1.4
Delta time in closed arm before/after self-admin	1.7	1.7	3.0	1.7	-1.1	0.2	-1.4	-1.4
Delta time in open arm before/after self-admin	0.4	0.4	1.0	1.0	-0.7	-0.1	-0.5	-0.5
Diff in mean of infusions in LGA sessions	0.4	0.5	0.7	-0.6	0.6	-0.4	0.8	0.8
Delay discount exponential model param	0.1	0.1	0.1	0.1	-0.4	0.2	-0.2	-0.2
Extinction: sum of active levers before priming	1.1	1.1	3.4	1.8	-0.7	-0.8	0.7	0.7
Active lever presses in extinction session 6	3.0	2.9	5.7	-2.4	1.6	-0.3	1.8	1.8
Bone: final force	2.8	4.6	11.6	1.7	-2.8	-3.4	-0.4	-0.4
Bone: final moment	2.7	4.3	10.0	1.8	-2.8	-3.2	-0.5	-0.5
Food consumed during 24 hour testing period	0.6	0.7	1.0	-0.8	0.8	-0.5	1.0	1.0
Glucose	0.1	0.1	0.2	0.0	0.1	-0.5	0.4	0.4
Heart weight	0.9	1.3	2.1	0.7	1.4	-0.1	1.4	1.4
Delay discount hyperbolic model param	0.0	0.0	0.1	0.1	-0.3	0.1	-0.2	-0.2
Intermittent access intake day 1-15 change	11.0	10.9	28.6	5.3	-3.1	-0.2	-2.8	-2.8
Intermittent access intake escalation	6.9	6.8	16.8	4.1	-2.4	-0.1	-2.4	-2.4
Intermittent access intake escalation 2	7.1	7.0	15.3	3.9	-2.6	0.4	-2.5	-2.5
Intermitt. access day 1 inactive lever presses	0.8	0.8	3.4	-1.9	0.7	0.6	0.1	0.1
Intermitt. access day 15 inactive lever presses	2.1	2.3	7.5	2.7	-1.4	-1.1	0.5	0.5
Intermitt. access escalation Index	0.4	0.3	1.0	-1.0	0.5	0.6	-0.2	-0.2
Intermittent access day 1 total infusions	1.0	1.2	2.4	0.2	0.3	-1.0	1.6	1.6
Intermittent access day 15 total infusions	3.0	3.4	12.4	3.5	-1.7	-1.0	-0.4	-0.4
Intermittent access terminal intake (last 3 days)	2.5	2.7	10.3	3.2	-1.5	-1.1	-0.1	-0.1
Intermittent access total infusions	1.3	1.5	3.9	2.0	-0.7	-1.2	0.9	0.9
Intermittent access day 1 locomotion	1.5	1.5	3.0	-0.7	0.7	-0.8	1.7	1.7
Intermittent access day 15 total locomotion	0.6	0.6	0.8	0.8	-0.1	-0.9	0.9	0.9
Intermittent access total locomotion	0.6	0.7	1.4	0.2	0.2	-0.7	1.2	1.2
Intermittent access standard deviation	2.2	2.3	6.8	2.6	-1.5	-0.2	-1.1	-1.1
Left kidney weight	0.4	1.2	3.0	1.7	-0.9	0.3	-1.0	-1.0
Right kidney weight	1.6	4.6	14.0	3.7	-1.8	-0.2	-1.7	-1.7
Cocaine induced anxiety	0.6	0.7	2.5	1.6	-0.7	-0.0	-0.4	-0.4
Post-drug Anxiety	0.3	0.4	0.6	0.3	-0.3	0.6	-0.8	-0.8
Baseline Anxiety	0.3	0.3	0.6	-0.5	-0.1	0.6	-0.8	-0.8
Tail length	1.2	3.7	6.6	2.6	-1.7	1.6	-1.9	-1.9
Length with tail	0.4	1.6	2.3	1.5	-1.4	0.9	-1.2	-1.2
Length without tail	0.2	0.4	1.4	-1.2	0.4	0.5	-0.1	-0.1
Times rat made contact with spout	0.1	0.1	0.2	-0.3	0.4	-0.2	0.3	0.3
Lifetime Intake	2.0	2.3	7.8	2.8	-1.1	-1.4	0.6	0.6
Liver weight, left	0.2	0.3	0.5	0.6	-0.6	-0.1	-0.7	-0.7
Liver weight, right	0.3	0.5	0.9	-0.3	0.0	-0.7	1.0	1.0
Locomotor activity	0.6	1.0	2.4	1.5	-1.4	-0.7	0.1	0.1
Locomotor testing distance	0.8	1.3	2.8	1.7	-1.5	-1.2	0.3	0.3
Locomotor testing rearing	0.3	0.4	0.6	0.6	-0.6	-0.8	0.6	0.6
Locomotion in novel chamber	0.3	0.4	0.8	-0.5	0.4	-0.4	0.9	0.9
Locomotion in novel chamber post-restriction	0.3	0.4	0.8	-0.1	0.2	-0.5	0.9	0.9
Fecal boli incidents, locomotor time 1	0.2	0.2	0.6	-0.8	0.3	-0.0	0.4	0.4
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	-0.0	-0.2	0.1	-0.0	-0.0
Time >=10cm from walls, locomotor time 1	0.2	0.3	0.5	0.1	-0.1	0.4	-0.7	-0.7
Bouts of movement, locomotor time 1	0.3	0.3	0.5	-0.6	0.5	-0.3	0.7	0.7
Total resting periods, locomotor time 1	0.0	0.0	0.1	-0.3	0.0	0.0	0.2	0.2
Rest time, locomotor task time 1	0.6	0.7	1.1	-0.3	-0.8	0.8	-1.0	-1.0
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.2	0.3	-0.4	0.4	0.4
Vertical activity count, locomotor time 1	1.1	1.2	1.6	-0.9	1.2	-0.6	1.3	1.3
Time >=10cm from walls, locomotor time 2	1.2	1.3	2.0	1.2	-0.9	0.6	-1.4	-1.4
Bouts of movement, locomotor time 2	0.4	0.4	0.8	0.3	-0.2	-0.6	0.9	0.9
Total resting periods, locomotor time 2	0.6	0.6	1.4	-0.1	0.1	-0.6	1.2	1.2
Rest time, locomotor task time 2	0.2	0.3	1.1	-1.1	0.2	0.2	0.1	0.1
Distance moved, locomotor task time 2	0.6	0.7	1.8	1.4	-0.7	0.1	-0.8	-0.8
Vertical activity count, locomotor time 2	0.1	0.1	0.5	0.7	-0.2	-0.1	-0.2	-0.2
Light reinforcement 1	0.6	1.1	1.6	1.3	-1.2	-0.3	-1.1	-1.1
Light reinforcement 2	0.4	0.5	0.9	1.0	-0.6	-0.5	-0.7	-0.7
Bone: marrow area	0.4	0.9	3.0	0.6	-1.1	-1.7	-0.1	-0.1
Bone: maximum diameter	1.0	1.8	5.1	0.9	-1.6	-2.3	0.5	0.5
Bone: maximum force	3.7	6.3	20.6	1.6	-2.9	-4.5	0.2	0.2
Bone: maximum moment	3.3	5.7	17.8	1.7	-2.9	-4.2	0.0	0.0
Mean time between licks in bursts	0.0	0.0	0.0	0.2	-0.2	0.1	-0.2	-0.2
Mean num. licks in bursts	0.2	0.2	0.4	0.3	-0.3	0.3	-0.6	-0.6
Cd content in liver	0.1	0.1	0.2	0.3	-0.4	-0.1	-0.4	-0.4
Co content in liver	4.9	5.7	19.5	1.6	-2.5	-4.4	0.3	0.3
Cu content in liver	1.4	1.7	3.8	0.6	-0.2	1.9	-1.5	-1.5
Fe content in liver	5.8	6.9	13.2	-2.9	3.6	2.2	2.0	2.0
K content in liver	0.1	0.1	0.3	0.6	-0.1	-0.1	-0.0	-0.0
Mg content in liver	0.8	0.8	1.9	0.6	0.2	1.4	-0.9	-0.9
Mn content in liver	0.6	0.7	1.1	-0.5	1.0	-0.3	1.1	1.1
Na content in liver	0.2	0.2	0.3	0.5	-0.1	0.5	-0.5	-0.5
Rb content in liver	0.0	0.1	0.2	0.1	0.1	0.5	-0.2	-0.2
Se content in liver	0.6	0.7	1.3	0.9	-1.1	-0.3	-0.8	-0.8
Sr content in liver	7.1	6.5	21.3	-0.2	-1.0	-4.6	2.2	2.2
Zn content in liver	0.5	0.5	0.8	0.8	-0.9	-0.4	-0.7	-0.7
Bone: minimum diameter	3.5	6.5	12.8	2.7	-3.6	-3.1	-1.2	-1.2
Time in familiar zone, hab. session 1	0.4	0.4	0.7	0.8	-0.3	0.2	-0.7	-0.7
Time in novel zone, hab. session 1	0.6	0.6	0.9	-0.9	0.6	-0.4	0.9	0.9
Total zone transitions, hab. session 1	0.1	0.2	0.3	-0.0	-0.1	-0.2	0.6	0.6
Total locomotion distance, hab. session 1	0.1	0.1	0.3	0.4	-0.6	0.1	-0.1	-0.1
Locomotion velocity, hab. session 1	0.3	0.4	0.8	0.7	-0.9	0.2	-0.4	-0.4
Time in familiar zone, hab. session 2	0.0	0.0	0.0	0.0	0.0	0.0	-0.1	-0.1
Time in novel zone, hab. session 2	0.1	0.1	0.1	-0.2	0.2	-0.2	0.4	0.4
Total zone transitions, hab. session 2	0.4	0.5	1.3	1.2	-0.6	0.2	-0.6	-0.6
Total locomotion distance, hab. session 2	0.1	0.1	0.4	0.6	-0.4	-0.0	0.1	0.1
Locomotion velocity, hab. session 2	0.1	0.2	0.6	0.8	-0.5	0.1	-0.2	-0.2
Novel to familiar place preference ratio	0.0	0.0	0.0	-0.2	0.0	-0.1	0.2	0.2
Novelty place preference	0.0	0.0	0.1	-0.2	0.1	-0.1	0.3	0.3
Time in novel zone, NPP test	0.2	0.2	0.4	-0.4	0.3	-0.3	0.6	0.6
Total zone transitions, NPP test	0.4	0.6	1.2	1.1	-0.6	0.2	-0.8	-0.8
Total locomotion distance, NPP test	0.2	0.3	0.6	0.8	-0.6	0.2	-0.4	-0.4
Locomotion velocity, NPP test	0.5	0.7	1.2	1.1	-0.9	0.3	-0.9	-0.9
Intraocular pressure	0.0	0.1	0.1	-0.4	0.1	0.1	0.3	0.3
Delta distance traveled before/after self-admin	1.4	1.5	3.9	2.0	-1.2	0.1	-1.0	-1.0
Delta ambulatory time before/after self-admin	1.7	1.9	6.0	2.4	-1.3	-0.2	-0.9	-0.9
Parametrial fat weight	2.4	4.6	7.9	2.8	-2.7	0.1	-2.0	-2.0
Pavlov. Cond. lever latency	0.6	0.7	1.3	0.2	0.6	1.1	-1.0	-1.0
Pavlov. Cond. magazine entry latency	1.1	1.4	3.4	1.0	-1.8	-1.6	-0.2	-0.2
Pavlov. Cond. change in total contacts	1.4	1.4	2.1	-1.2	1.4	0.7	1.3	1.3
Pavlov. Cond. index score	0.3	0.4	1.1	0.3	-1.0	-0.9	0.3	0.3
Pavlov. Cond. latency score	0.2	0.3	0.6	0.2	-0.8	-0.7	0.4	0.4
Pavlov. Cond. lever contacts	0.5	0.6	1.2	-0.4	0.0	-0.6	1.1	1.1
Pavlov. Cond. magazine entry number	0.7	0.9	2.5	-0.9	1.6	0.8	0.5	0.5
Pavlov. Cond. intertrial magazine entries	2.1	2.6	4.9	-1.7	2.2	0.6	1.5	1.5
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.1	0.3	-1.0	-1.0	0.3	0.3
Pavlov. Cond. response bias	0.3	0.4	0.5	-0.2	-0.3	-0.7	0.7	0.7
Pavlov. Cond. lever latency	0.2	0.3	1.2	0.1	0.5	1.1	-0.3	-0.3
Pavlov. Cond. magazine entry latency	0.7	0.8	1.2	0.7	-1.0	0.0	-1.1	-1.1
Pavlov. Cond. change in total contacts	0.2	0.2	0.7	0.1	-0.7	-0.9	0.0	0.0
Pavlov. Cond. index score	0.1	0.1	0.4	-0.0	-0.4	-0.6	0.0	0.0
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.2	-0.1	-0.3	-0.0	-0.0
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.1	-0.5	-0.4	-0.1	-0.1
Pavlov. Cond. magazine entry number	0.0	0.1	0.2	0.1	0.0	0.5	-0.1	-0.1
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.6	-0.5	0.7	0.8	0.5	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	1.0	0.1	-0.5	-1.0	0.1	0.1
Pavlov. Cond. response bias	0.1	0.2	0.5	0.1	-0.6	-0.7	-0.0	-0.0
Time in closed arm before self-admin	0.2	0.2	0.3	0.1	-0.4	0.5	-0.5	-0.5
Time in closed arm after self-admin	0.3	0.3	0.6	0.1	-0.3	0.5	-0.8	-0.8
Time in open arm before self-admin	0.5	0.5	0.8	-0.9	0.8	-0.3	0.7	0.7
Time in open arm after self-admin	0.1	0.2	0.5	0.7	-0.3	-0.4	0.0	0.0
Bone: periosteal estimation	2.2	4.6	12.8	1.7	-2.7	-3.6	-0.2	-0.2
Bone: periosteal perimeter	1.8	3.0	6.2	1.6	-2.4	-2.5	-0.5	-0.5
Bone: post-yield work	0.8	1.1	2.5	1.2	-1.6	-0.9	-0.7	-0.7
Progressive ratio test 1 active lever presses	2.1	2.2	4.2	0.6	0.2	-1.5	2.1	2.1
Progressive ratio test 1 breakpoint	1.9	2.0	3.9	0.5	0.3	-1.4	2.0	2.0
Progressive ratio test 1 inactive lever presses	0.9	1.0	2.7	1.6	-0.6	-1.1	0.6	0.6
Progressive ratio test 2 active lever presses	2.1	2.2	3.2	1.8	-0.3	-1.4	1.7	1.7
Progressive ratio test 2 breakpoint	2.2	2.5	4.2	2.0	-0.5	-1.5	1.7	1.7
Progressive ratio test 2 inactive lever presses	2.1	2.4	7.9	2.8	-1.1	-1.4	0.7	0.7
Incentive Sensitization - Responses	1.7	1.7	6.0	2.5	-1.2	-0.8	0.5	0.5
Incentive Sensitization - Breakpoint	1.8	1.8	6.2	2.5	-1.1	-0.9	0.6	0.6
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.3	0.4	-0.1	0.4	0.4
Progressive ratio	0.2	0.2	0.7	0.8	-0.5	0.1	-0.4	-0.4
Food seeking constrained by brief footshock	0.6	0.8	1.8	1.3	-0.5	0.2	-1.0	-1.0
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.2	-0.0	0.2	-0.4	-0.4
Retroperitoneal fat weight	0.8	2.6	3.9	1.7	-2.0	0.2	-1.7	-1.7
Reaction time number correct	0.2	0.4	0.7	0.8	-0.3	0.4	-0.6	-0.6
Reaction time mean minus median	3.0	4.0	9.2	-1.7	3.0	1.1	1.8	1.8
Reaction time mean minus median AUC	2.9	3.8	9.5	-1.5	3.1	2.0	1.3	1.3
Reaction time num false alarms	1.5	2.1	5.8	1.0	-1.9	-2.4	0.2	0.2
Reaction time num false alarms AUC	3.1	4.3	9.9	1.8	-2.9	-3.1	-0.1	-0.1
Reaction time trials correct on left	0.2	0.4	0.7	0.8	-0.3	0.4	-0.6	-0.6
Reaction time trials on left	0.3	0.4	0.7	0.8	-0.2	0.5	-0.6	-0.6
Reaction time mean	2.1	2.9	6.6	-1.3	2.6	1.6	1.4	1.4
Reaction time mean AUC	2.1	2.8	6.5	-1.4	2.6	1.8	1.1	1.1
Median of all reaction times	1.3	1.8	3.9	-1.0	2.0	1.5	0.9	0.9
Reaction time omissions	0.7	0.9	2.6	0.2	1.2	1.6	-0.5	-0.5
Reaction time false alarm rate	2.1	2.9	8.7	0.9	-2.2	-2.9	0.4	0.4
Reaction time premature initiation rate	0.6	0.8	2.1	-0.9	0.7	1.5	0.4	0.4
Reaction time premature initiations	0.4	0.5	2.1	-0.4	0.6	1.5	0.1	0.1
Std. dev. reaction times	2.3	3.2	6.7	-1.5	2.6	0.5	1.8	1.8
Reaction time trials completed	0.3	0.4	0.7	0.8	-0.2	0.5	-0.6	-0.6
Reaction time trials AUC	0.2	0.3	0.5	0.7	-0.3	0.5	-0.6	-0.6
Run reversals in cocaine runway, females	1.2	1.1	1.7	1.3	-1.2	0.2	-1.1	-1.1
Run reversals in cocaine runway, males	1.9	1.8	4.4	2.1	-1.5	0.1	-1.0	-1.0
Latency to leave start box in cocaine runway	0.5	0.6	2.6	-1.6	0.5	0.2	0.1	0.1
Latency to leave start box in cocaine runway, F	0.6	0.7	1.2	-0.3	-0.7	0.6	-1.1	-1.1
Latency to leave start box in cocaine runway, M	3.4	3.2	6.8	-2.6	2.0	-0.3	1.6	1.6
Std. dev. time between licks in bursts	0.0	0.0	0.0	-0.0	0.0	-0.1	0.2	0.2
Total sessions with >9 infusions	1.1	1.2	2.5	1.6	-0.3	-1.3	0.9	0.9
Short access day 1 total inactive lever presses	0.8	0.9	1.5	-1.2	1.1	-0.6	0.9	0.9
Short access day 10 total inactive lever presses	0.2	0.2	0.4	-0.4	0.2	-0.1	0.7	0.7
Short access day 1 total infusions	2.2	2.4	8.5	2.9	-1.2	-1.4	0.0	0.0
Short access day 10 total infusions	1.5	1.7	3.9	2.0	-0.5	-1.5	1.1	1.1
Short access total infusions	2.6	2.9	10.3	3.2	-1.3	-1.5	0.4	0.4
Short access day 1 locomotion	0.3	0.3	0.8	0.3	0.2	-0.9	0.6	0.6
Short access day 10 total locomotion	2.0	2.2	5.2	-2.3	1.2	-0.1	1.5	1.5
Short access total locomotion	1.2	1.3	1.9	-1.1	0.9	-0.6	1.4	1.4
One hour access (0.3 mA shock)	3.4	4.0	15.4	3.9	-1.8	-1.2	-0.2	-0.2
Compulsive drug intake	0.1	0.1	0.2	0.0	-0.3	0.3	-0.4	-0.4
One hour access (shock baseline)	1.7	2.0	7.7	2.8	-1.0	-1.1	0.2	0.2
Social response proportion	0.0	0.0	0.1	0.0	0.4	-0.1	-0.1	-0.1
Social responses	0.0	0.1	0.2	0.2	0.4	-0.2	0.1	0.1
Social time	0.1	0.2	0.4	0.3	-0.0	0.7	-0.5	-0.5
Soleus weight	3.5	10.1	17.0	-3.7	4.1	1.7	2.9	2.9
Bone: stiffness	2.5	4.0	13.2	1.1	-2.2	-3.6	0.4	0.4
Tibialis anterior weight	1.6	5.4	8.1	-2.7	2.8	1.2	2.3	2.3
Time to tail flick, vehicle, before self-admin	0.8	0.9	2.8	1.7	-1.1	-0.2	-0.4	-0.4
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.4	0.6	-0.6	0.2	-0.6	-0.6
Time to tail flick, test, before self-admin	0.8	0.8	1.5	0.2	0.5	-0.9	1.2	1.2
Time to tail flick, test, after self-admin	0.6	0.6	0.9	1.0	-0.7	0.2	-0.9	-0.9
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.7	-0.9	0.3	0.5	-0.4	-0.4
Delta time to tail flick, test, before/after SA	2.2	2.0	3.8	0.5	-0.9	1.1	-1.9	-1.9
Tibia length	1.0	3.0	7.2	1.5	-2.7	-0.9	-1.5	-1.5
Ambulatory time before self-admin	1.5	1.5	5.4	-2.3	1.2	0.7	0.4	0.4
Ambulatory time after self-admin	0.6	0.6	1.1	-0.3	-0.2	0.8	-1.1	-1.1
Bone: tissue strength	0.0	0.0	0.0	0.2	-0.0	-0.2	-0.0	-0.0
Total heroin consumption	7.0	8.2	12.0	-3.2	2.4	-0.9	3.5	3.5
Bone: trabecular number	0.1	0.2	0.6	0.2	0.3	0.8	-0.2	-0.2
Bone: trabecular spacing	0.8	1.0	1.6	-1.0	1.3	1.0	0.8	0.8
Bone: trabecular thickness	2.5	3.0	6.2	1.5	-2.4	-2.5	-0.5	-0.5
Bone: trabecular tissue density	0.1	0.1	0.2	-0.5	-0.2	0.0	0.3	0.3
Water consumed over 24 hours	1.6	1.9	2.7	-1.3	1.4	-0.7	1.6	1.6
Number of responses in last shaping day	1.8	1.8	2.5	1.3	0.0	-1.6	1.5	1.5