Hub : Genes

Hspa1a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Hspa1a 0.3 0.2 2.0e-03 0.02 0.07 0.05 0.07 9.2e-02 1.0e-02 2.6e-02 1.0e-02
2 PL gene expression Hspa1a 0.22 0.1 0.0e+00 0.22 0.21 0.2 0.22 2.8e-24 1.3e-22 6.3e-21 9.8e-24
3 OFC gene expression Hspa1a 0.17 0.1 2.6e-03 0.12 0.08 0.05 0.13 9.3e-04 5.4e-03 2.4e-02 4.7e-04
4 IL gene expression Hspa1a 0.26 0.13 4.8e-05 0.19 0.12 0.15 0.2 2.0e-05 7.2e-04 2.4e-04 1.3e-05
5 Adipose gene expression Hspa1a 0.11 0.05 6.9e-13 0.08 0.11 0.12 0.11 5.6e-09 1.9e-12 8.8e-13 3.3e-12
6 IC gene expression Hspa1a 0.33 0.12 8.3e-10 0.24 0.17 0.15 0.18 2.7e-10 1.1e-07 5.6e-07 3.3e-08
7 Liver gene expression Hspa1a 0.26 0.08 0.0e+00 0.21 0.25 0.28 0.28 1.6e-22 5.8e-28 1.2e-30 2.7e-31
8 NAcc gene expression Hspa1a 0.17 0.07 0.0e+00 0.12 0.14 0.14 0.15 1.8e-18 3.1e-21 1.2e-20 1.2e-21
9 Brain gene expression Hspa1a 0.29 0.09 0.0e+00 0.21 0.24 0.25 0.25 1.1e-19 1.6e-22 2.8e-23 3.3e-23
10 pVTA gene expression Hspa1a 0.18 0.1 5.8e-09 0.08 0.09 0.09 0.08 7.0e-07 1.0e-07 1.8e-07 3.6e-07
11 BLA gene expression Hspa1a 0.21 0.1 1.2e-07 0.15 0.14 0.13 0.15 2.9e-08 4.6e-08 2.0e-07 1.9e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.40.74.10.5-0.7-0.7-2.0-1.00.2-0.7-0.8-0.4-0.2-0.6
Area under the delay curve0.10.10.3-0.1-0.1-0.00.40.1-0.6-0.4-0.2-0.4-0.3-0.3
BMI with tail1.86.210.61.82.22.21.51.13.32.72.62.93.03.1
BMI without tail2.78.211.02.33.23.33.03.12.83.02.82.72.62.6
Body weight2.912.518.21.13.33.33.92.33.54.14.34.23.74.0
Weight adjusted by age2.53.97.9-0.11.61.72.81.01.42.22.62.31.82.5
Bone surface0.00.00.1-0.4-0.1-0.2-0.1-0.2-0.00.20.10.20.00.2
Bone volume0.10.10.30.40.10.1-0.4-0.20.50.30.20.40.40.3
Breakpoint value in progressive ratio session0.40.51.0-0.4-0.5-0.6-0.5-0.2-0.8-0.8-0.9-0.8-0.8-1.0
Number of licking bursts1.01.62.8-1.7-1.4-1.6-0.6-0.9-1.6-1.1-1.1-1.1-1.3-1.3
Context. condit. distance diff. score4.75.69.8-3.1-3.0-3.0-2.1-2.9-2.0-2.1-1.9-1.7-1.9-1.5
Locomotion velocity, session 11.01.11.9-1.0-1.0-1.0-0.6-0.1-1.2-1.3-1.0-1.2-1.4-1.1
Locomotion distance, session 10.60.82.7-0.0-1.0-1.0-1.7-0.7-0.3-1.0-1.0-0.8-0.6-0.8
Locomotion velocity, session 21.01.11.8-0.9-1.3-1.2-0.8-0.6-1.2-1.2-1.0-1.2-1.1-0.9
Locomotion distance, session 21.21.73.6-1.0-1.7-1.6-1.9-1.9-0.5-1.3-1.1-0.9-0.7-0.6
Locomotion velocity, session 30.20.21.01.00.50.50.20.90.4-0.1-0.2-0.2-0.0-0.0
Locomotion distance, session 31.61.83.2-0.3-1.4-1.4-1.8-1.1-0.9-1.6-1.6-1.5-1.2-1.2
Stereotopy head waving bouts, day 30.20.31.4-0.70.30.21.20.7-0.30.40.40.30.00.3
Stereotopy head waving duration, day 30.70.93.3-0.11.01.01.81.6-0.10.80.80.50.20.3
Locomotion velocity, session 73.94.29.6-1.3-2.4-2.3-3.0-3.1-0.9-2.2-2.0-1.6-1.2-1.2
Locomotion distance, session 74.45.610.5-1.0-2.5-2.5-3.2-2.8-1.6-2.7-2.6-2.3-1.9-1.8
Stereotopy head waving bouts, day 70.70.73.60.50.50.30.61.9-1.0-0.4-0.5-0.8-1.0-0.8
Stereotopy head waving duration, day 70.50.64.30.60.70.60.92.1-0.40.10.0-0.2-0.3-0.4
Locomotion velocity, session 82.93.58.9-3.0-2.3-2.3-0.7-1.3-2.2-1.6-1.3-1.6-1.9-1.3
Locomotion distance, session 84.97.214.8-3.2-3.5-3.5-2.9-3.8-1.6-2.4-2.1-1.7-1.7-1.3
Degree of sensitization distance0.50.51.5-1.2-0.8-0.8-0.2-1.1-0.7-0.5-0.4-0.3-0.5-0.1
Degree of sensitization stereotypy0.80.92.00.4-0.1-0.2-0.21.4-1.1-0.8-1.0-1.1-1.2-1.3
Conditioned locomotion0.50.61.1-0.50.30.30.8-0.40.60.90.91.00.91.0
Cocaine response after cond. corrected0.81.05.5-1.0-1.1-1.1-1.1-2.40.1-0.2-0.10.20.30.5
Cocaine response after cond. not corrected0.30.31.2-1.1-0.6-0.60.1-1.0-0.20.10.20.20.10.4
Cocaine response before conditioning1.72.19.00.31.41.52.73.0-0.11.11.10.50.10.1
Saline control response4.86.411.03.03.23.32.43.31.92.42.11.91.91.8
Bone: connectivity density0.30.52.6-0.1-0.8-0.7-1.6-1.10.3-0.3-0.40.00.1-0.0
Bone: cortical apparent density1.41.93.31.81.51.50.60.71.71.31.21.41.61.4
Bone: cortical area0.00.00.1-0.10.0-0.10.20.4-0.00.10.10.00.00.2
Bone: cortical porosity1.21.33.10.40.30.30.51.8-1.5-1.0-1.0-1.3-1.5-1.4
Bone: cortical porosity1.11.22.8-0.10.00.10.51.6-1.7-1.0-0.9-1.3-1.6-1.3
Bone: cortical thickness0.50.83.11.70.90.8-0.11.21.00.50.30.50.80.5
Bone: cortical thickness1.41.64.62.11.31.30.21.51.61.00.70.91.20.9
Bone: cortical tissue density1.31.82.91.71.51.40.60.71.71.31.21.41.51.3
Condit. Reinf. active minus inactive responses1.11.22.4-0.0-0.8-0.7-0.90.1-1.1-1.5-1.5-1.5-1.3-1.3
Condit. Reinf. active-inactive response ratio0.30.31.51.00.40.50.21.20.0-0.2-0.3-0.4-0.1-0.3
Condit. Reinf. active responses0.91.12.0-0.0-0.9-0.8-1.4-0.8-0.6-1.4-1.3-1.3-0.9-1.0
Condit. Reinf. inactive responses1.01.34.30.2-0.9-1.0-2.1-1.7-0.1-1.2-1.2-0.8-0.5-0.9
Incentive salience index mean3.03.74.9-1.6-2.2-2.1-1.8-1.8-1.7-2.2-2.0-2.0-1.8-1.6
Condit. Reinf. lever presses4.15.813.7-2.9-3.0-3.0-2.4-3.7-1.7-2.1-1.8-1.6-1.6-1.4
Condit. Reinf. active minus inactive responses0.40.61.80.20.90.91.31.20.20.60.70.30.20.3
Condit. Reinf. active-inactive response ratio0.50.62.8-0.40.70.81.71.1-0.10.70.80.40.10.5
Condit. Reinf. active responses0.20.20.80.40.60.60.70.90.20.30.30.10.10.1
Condit. Reinf. inactive responses0.10.20.90.90.40.3-0.20.50.50.1-0.10.10.30.0
Condit. Reinf. lever presses0.10.20.40.2-0.10.0-0.20.5-0.5-0.5-0.6-0.6-0.7-0.4
Condit. Reinf. lever reinforcers received0.10.10.80.20.40.40.50.9-0.20.0-0.0-0.2-0.2-0.2
Conditioned reinforcement - actives0.10.20.40.60.40.60.20.10.60.30.30.30.40.4
Conditioned reinforcement - inactives0.20.30.60.60.80.80.50.20.50.40.50.40.40.2
Conditioned locomotion0.10.10.2-0.10.20.30.3-0.10.40.20.40.40.20.3
Patch foraging indifference point 0 sec2.13.86.32.22.52.41.72.31.71.81.81.61.71.5
Patch foraging indifference point AUC0.20.31.10.20.10.20.31.0-1.0-0.3-0.3-0.6-0.7-0.6
Delay disc. indifference point, 0s delay0.40.51.9-1.1-0.7-0.7-0.1-1.4-0.7-0.5-0.2-0.3-0.4-0.2
Delay disc. indifference point, 16s delay0.20.20.80.90.50.50.10.60.2-0.2-0.2-0.10.10.0
Delay disc. indifference point, 2s delay0.30.31.0-1.0-0.2-0.11.00.3-1.0-0.3-0.0-0.4-0.4-0.4
Delay disc. indifference point, 24s delay0.30.31.00.50.70.81.01.0-0.1-0.10.10.0-0.10.4
Delay disc. indifference point, 4s delay0.30.31.60.10.50.61.30.9-0.30.30.40.10.1-0.0
Delay disc. indifference point, 8s delay0.20.30.5-0.2-0.4-0.4-0.2-0.3-0.6-0.7-0.5-0.6-0.5-0.7
Indifference point function ln k0.61.01.3-1.1-0.9-1.1-0.5-0.7-1.1-1.1-1.1-1.1-1.1-1.2
Indifference point function log k0.61.01.3-1.1-0.9-1.1-0.5-0.7-1.1-1.1-1.1-1.1-1.1-1.2
Patch foraging total patch changes 0 sec2.14.06.52.42.62.51.72.31.71.81.81.61.71.5
Patch foraging total patch changes 12 sec1.82.34.81.91.91.91.32.20.91.31.21.01.01.2
Patch foraging total patch changes 18 sec1.82.87.02.61.92.00.41.51.91.51.31.41.71.2
Patch foraging total patch changes 24 sec0.40.83.82.01.01.0-0.50.70.90.30.20.50.70.4
Patch foraging total patch changes 6 sec2.13.25.02.22.22.21.32.21.51.61.61.41.51.5
Patch foraging time to switch 0 sec1.02.04.90.50.70.70.1-0.82.21.41.41.92.02.0
Patch foraging water rate 0 sec0.10.10.30.20.60.40.50.20.20.40.50.40.30.4
Patch foraging water rate 12 sec0.10.20.70.90.20.0-0.70.20.2-0.2-0.4-0.20.0-0.5
Patch foraging water rate 18 sec0.20.40.70.70.90.50.40.70.60.50.40.60.50.6
Patch foraging water rate 24 sec0.20.20.60.80.70.40.10.50.50.40.20.30.40.1
Patch foraging water rate 6 sec0.10.10.40.60.30.1-0.20.00.2-0.0-0.10.00.2-0.5
Seeking ratio, delayed vs. immediate footshock0.70.84.61.30.90.80.92.2-0.40.4-0.0-0.3-0.2-0.5
Distance traveled before self-admin0.30.40.8-0.4-0.2-0.20.1-0.80.60.70.70.90.70.9
Distance traveled after self-admin0.81.02.20.40.90.91.51.20.41.31.10.90.80.9
Extensor digitorum longus weight0.10.31.2-1.1-0.2-0.20.5-0.90.10.30.40.50.10.5
Bone: elastic displacement0.20.20.91.00.50.6-0.10.7-0.0-0.3-0.2-0.3-0.2-0.5
Bone: elastic work0.10.20.30.50.50.60.40.50.30.30.40.30.30.1
Bone: endosteal estimation1.02.28.8-1.80.90.73.00.80.01.61.81.30.61.4
Bone: endosteal perimeter0.51.06.4-2.5-0.9-1.00.9-0.9-0.90.10.30.0-0.50.1
Epididymis fat weight4.816.433.45.24.34.31.21.75.83.83.34.04.93.6
Delta time in closed arm before/after self-admin0.80.71.3-0.30.50.50.9-0.50.71.01.11.21.01.1
Delta time in open arm before/after self-admin0.20.20.50.60.50.60.20.70.50.10.10.10.30.1
Diff in mean of infusions in LGA sessions2.32.85.9-1.0-2.0-2.0-2.4-2.1-0.7-1.5-1.6-1.4-1.2-1.3
Delay discount exponential model param0.10.10.40.10.0-0.1-0.5-0.40.70.40.30.40.40.4
Extinction: sum of active levers before priming0.70.71.4-1.2-1.1-1.1-0.4-0.9-1.0-0.8-0.6-0.6-0.8-0.5
Active lever presses in extinction session 60.10.10.20.40.40.5-0.1-0.20.4-0.20.00.30.20.1
Bone: final force1.93.04.01.21.61.61.31.22.02.01.92.02.02.0
Bone: final moment1.72.73.51.11.61.61.31.11.81.91.81.91.81.8
Food consumed during 24 hour testing period0.50.61.4-0.9-0.0-0.10.6-0.90.60.80.90.90.91.2
Glucose2.43.713.3-3.7-2.1-2.2-0.2-1.9-2.3-1.5-1.1-1.2-1.8-0.8
Heart weight1.21.96.30.21.61.62.51.80.41.31.51.00.70.9
Delay discount hyperbolic model param0.20.20.60.1-0.0-0.1-0.6-0.50.80.40.30.50.50.5
Intermittent access intake day 1-15 change0.10.20.80.5-0.10.1-0.30.9-0.2-0.1-0.3-0.4-0.4-0.4
Intermittent access intake escalation0.30.52.51.50.50.7-0.11.60.10.1-0.2-0.4-0.2-0.4
Intermittent access intake escalation 20.30.30.60.2-0.4-0.2-0.30.6-0.8-0.5-0.7-0.8-0.8-0.7
Intermitt. access day 1 inactive lever presses0.20.83.5-1.9-0.9-1.00.3-1.6-0.8-0.00.0-0.0-0.20.2
Intermitt. access day 15 inactive lever presses0.20.51.1-0.00.50.61.00.30.50.90.90.80.60.9
Intermitt. access escalation Index2.12.94.4-1.4-2.1-2.0-1.9-2.1-1.4-1.6-1.6-1.5-1.2-1.8
Intermittent access day 1 total infusions0.30.51.1-0.2-0.6-0.4-1.0-0.9-0.3-1.1-0.8-0.7-0.6-0.7
Intermittent access day 15 total infusions0.20.31.01.00.20.3-0.60.70.0-0.5-0.6-0.6-0.4-0.6
Intermittent access terminal intake (last 3 days)0.20.30.90.90.60.70.10.90.0-0.2-0.2-0.3-0.2-0.3
Intermittent access total infusions0.10.10.40.60.30.4-0.10.30.2-0.4-0.3-0.3-0.2-0.4
Intermittent access day 1 locomotion0.10.20.60.40.20.3-0.3-0.50.80.20.20.50.40.4
Intermittent access day 15 total locomotion0.40.81.10.80.80.90.60.81.01.00.91.00.81.0
Intermittent access total locomotion0.40.51.11.00.80.90.40.51.00.60.60.70.60.6
Intermittent access standard deviation1.63.34.61.72.02.11.81.81.81.91.81.81.71.8
Left kidney weight2.712.715.72.13.73.83.92.93.54.03.93.83.53.6
Right kidney weight2.712.116.71.73.43.53.72.03.54.14.14.03.73.7
Cocaine induced anxiety0.20.31.0-0.8-0.9-0.8-0.3-1.0-0.4-0.3-0.3-0.2-0.2-0.0
Post-drug Anxiety0.10.10.3-0.3-0.10.10.5-0.10.00.40.30.20.30.2
Baseline Anxiety0.20.20.70.30.50.50.60.80.30.50.50.30.3-0.2
Tail length0.93.414.5-0.51.71.83.82.60.01.82.01.30.51.0
Length with tail1.35.617.6-0.92.02.04.21.81.02.73.12.41.72.3
Length without tail2.37.313.1-1.01.71.63.1-0.32.53.23.63.63.03.6
Times rat made contact with spout0.91.02.81.70.1-0.0-1.20.9-0.3-1.1-1.3-1.2-0.8-1.2
Lifetime Intake0.10.10.30.50.40.50.00.20.2-0.2-0.1-0.2-0.1-0.3
Liver weight, left0.50.92.7-1.6-0.0-0.01.4-0.30.10.91.11.00.51.1
Liver weight, right0.50.84.4-2.1-0.4-0.31.4-0.5-0.60.40.70.6-0.10.9
Locomotor activity0.40.62.70.00.70.61.61.7-0.50.50.50.1-0.10.0
Locomotor testing distance0.10.31.2-0.40.40.41.10.6-0.10.50.60.30.20.3
Locomotor testing rearing0.51.02.0-0.30.80.81.40.40.81.31.41.20.91.1
Locomotion in novel chamber0.00.00.10.20.30.10.10.3-0.10.20.1-0.00.2-0.2
Locomotion in novel chamber post-restriction1.22.02.90.91.51.51.41.01.51.71.71.41.51.3
Fecal boli incidents, locomotor time 10.20.30.7-0.20.30.40.1-0.70.80.40.60.70.80.5
Change in fecal boli incidents, locomotor task0.30.31.1-1.1-0.5-0.60.7-0.4-0.80.20.2-0.0-0.30.2
Time >=10cm from walls, locomotor time 11.61.73.1-0.80.50.51.6-0.61.01.61.71.71.51.8
Bouts of movement, locomotor time 10.91.01.6-0.2-1.1-1.0-1.2-0.5-0.9-1.2-1.3-1.1-1.0-0.9
Total resting periods, locomotor time 10.60.71.1-0.4-1.0-1.0-1.0-0.5-0.8-1.0-1.0-0.9-0.8-0.6
Rest time, locomotor task time 10.10.10.4-0.60.1-0.00.5-0.0-0.4-0.00.1-0.1-0.20.0
Distance moved, locomotor task time 10.10.20.30.60.40.40.40.50.50.40.40.50.40.3
Vertical activity count, locomotor time 10.30.71.10.90.80.80.40.80.90.90.90.91.00.5
Time >=10cm from walls, locomotor time 20.81.22.9-0.80.50.61.7-0.20.61.41.71.41.11.2
Bouts of movement, locomotor time 20.20.41.0-0.0-0.1-0.00.20.8-1.0-0.5-0.7-0.8-0.7-0.7
Total resting periods, locomotor time 20.40.82.3-0.5-0.4-0.40.20.7-1.5-0.9-1.0-1.1-1.1-1.0
Rest time, locomotor task time 20.81.03.8-1.9-1.2-1.4-0.4-1.6-0.9-0.4-0.4-0.3-0.4-0.1
Distance moved, locomotor task time 21.31.62.81.31.21.30.70.71.71.11.41.51.31.3
Vertical activity count, locomotor time 21.01.31.90.71.21.10.90.61.31.11.41.41.31.3
Light reinforcement 10.30.71.30.30.10.30.1-0.51.21.00.91.11.11.0
Light reinforcement 20.40.61.4-0.5-0.2-0.10.1-1.01.10.70.81.00.91.2
Bone: marrow area1.22.59.8-1.71.10.93.10.90.21.82.01.50.81.5
Bone: maximum diameter0.71.44.8-2.2-1.4-1.5-0.1-0.8-1.4-0.9-0.7-0.8-1.1-0.6
Bone: maximum force1.11.93.00.71.31.11.20.71.61.61.51.71.61.7
Bone: maximum moment1.01.72.50.51.31.11.20.71.41.51.51.51.41.6
Mean time between licks in bursts0.82.05.1-2.3-1.5-1.6-0.4-1.1-1.9-1.2-1.0-1.2-1.5-1.3
Mean num. licks in bursts1.01.56.12.51.41.50.11.51.40.60.40.50.80.6
Cd content in liver0.70.82.30.30.40.3-0.5-0.81.50.70.81.11.31.1
Co content in liver2.12.54.01.11.51.51.21.02.01.61.71.81.81.9
Cu content in liver1.01.22.91.5-0.4-0.5-1.7-0.2-0.3-1.2-1.6-1.3-0.7-1.1
Fe content in liver1.21.52.01.31.41.40.80.31.31.31.21.41.41.1
K content in liver0.80.71.4-0.5-1.0-1.1-1.2-0.9-0.6-0.9-1.0-0.7-0.7-0.5
Mg content in liver2.82.84.9-2.2-2.2-2.2-1.4-1.6-1.6-1.5-1.5-1.4-1.5-1.0
Mn content in liver2.22.47.9-2.8-2.0-2.0-0.6-2.4-1.1-1.0-0.8-0.7-1.0-0.6
Na content in liver0.60.61.20.8-0.3-0.3-0.70.2-0.9-0.7-1.0-1.0-0.8-1.1
Rb content in liver0.30.42.1-0.6-0.4-0.4-0.8-1.40.20.20.10.40.30.8
Se content in liver3.94.66.9-2.3-2.3-2.2-1.0-0.9-2.6-2.3-2.2-2.5-2.5-2.0
Sr content in liver0.60.50.9-0.40.70.60.90.10.70.80.90.90.71.0
Zn content in liver0.10.10.6-0.8-0.3-0.30.0-0.3-0.0-0.00.00.1-0.10.5
Bone: minimum diameter0.30.64.1-2.0-0.6-0.70.8-0.7-0.50.20.50.3-0.20.4
Time in familiar zone, hab. session 10.70.72.91.70.20.2-1.40.60.0-0.8-0.9-0.8-0.4-0.6
Time in novel zone, hab. session 10.80.83.0-1.10.30.41.70.20.21.01.21.00.60.8
Total zone transitions, hab. session 10.40.61.0-0.5-1.0-0.9-1.0-0.6-0.7-0.8-0.8-0.7-0.7-0.6
Total locomotion distance, hab. session 10.40.61.2-0.6-0.9-1.0-1.1-1.1-0.4-0.7-0.7-0.5-0.5-0.3
Locomotion velocity, hab. session 10.20.30.7-0.5-0.7-0.7-0.8-0.6-0.4-0.6-0.6-0.5-0.5-0.3
Time in familiar zone, hab. session 20.30.31.81.30.50.5-0.21.10.40.2-0.1-0.00.20.3
Time in novel zone, hab. session 20.10.10.4-0.30.40.40.70.1-0.00.30.50.40.20.1
Total zone transitions, hab. session 20.10.20.8-0.2-0.6-0.5-0.7-0.90.1-0.0-0.10.00.20.1
Total locomotion distance, hab. session 20.81.03.4-0.7-1.3-1.3-1.6-1.9-0.3-0.6-0.7-0.4-0.2-0.3
Locomotion velocity, hab. session 21.31.74.7-1.0-1.7-1.7-1.9-2.2-0.6-1.0-1.1-0.8-0.6-0.7
Novel to familiar place preference ratio0.20.20.4-0.0-0.1-0.2-0.3-0.4-0.7-0.5-0.5-0.5-0.6-0.6
Novelty place preference0.20.20.6-0.0-0.0-0.1-0.0-0.1-0.8-0.4-0.4-0.5-0.6-0.6
Time in novel zone, NPP test0.10.20.60.00.10.10.20.2-0.8-0.3-0.3-0.4-0.6-0.6
Total zone transitions, NPP test0.91.33.0-1.0-1.5-1.5-1.7-1.5-0.6-1.0-0.9-0.8-0.7-0.6
Total locomotion distance, NPP test0.81.04.6-0.9-1.2-1.2-1.6-2.10.2-0.6-0.4-0.10.00.1
Locomotion velocity, NPP test1.21.86.9-1.1-1.6-1.6-2.1-2.6-0.0-0.9-0.8-0.4-0.2-0.2
Intraocular pressure0.20.31.11.10.30.4-0.4-0.10.90.20.30.50.50.5
Delta distance traveled before/after self-admin1.21.25.20.91.41.41.72.3-0.20.60.60.10.10.0
Delta ambulatory time before/after self-admin0.60.83.50.51.11.01.51.9-0.40.50.4-0.0-0.00.0
Parametrial fat weight2.04.710.01.71.61.80.80.13.22.32.22.62.72.8
Pavlov. Cond. lever latency5.67.18.82.93.02.91.92.42.92.72.42.62.82.5
Pavlov. Cond. magazine entry latency3.74.77.8-1.6-2.0-1.9-1.2-0.7-2.8-2.4-2.3-2.5-2.7-2.7
Pavlov. Cond. change in total contacts2.02.23.6-1.2-1.3-1.3-0.6-0.5-1.9-1.6-1.6-1.8-1.8-1.8
Pavlov. Cond. index score5.77.19.6-2.6-2.8-2.8-1.8-2.0-3.1-2.8-2.6-2.8-3.0-2.8
Pavlov. Cond. latency score6.07.610.4-2.7-2.9-2.9-1.8-2.1-3.2-2.9-2.7-2.8-3.1-2.9
Pavlov. Cond. lever contacts4.85.79.1-3.0-2.8-2.7-1.7-2.7-2.5-2.3-1.9-2.0-2.3-2.0
Pavlov. Cond. magazine entry number2.53.14.81.31.61.61.00.62.22.01.92.02.12.2
Pavlov. Cond. intertrial magazine entries1.01.23.31.41.10.9-0.2-0.01.80.80.71.11.41.1
Pavlov. Cond. lever-magazine prob. diff.5.77.09.2-2.5-2.8-2.8-1.8-2.0-3.0-2.8-2.6-2.8-2.9-2.8
Pavlov. Cond. response bias4.04.96.2-2.2-2.3-2.3-1.5-1.6-2.5-2.4-2.2-2.3-2.4-2.4
Pavlov. Cond. lever latency0.20.31.1-1.1-0.4-0.50.2-0.9-0.00.30.40.30.2-0.1
Pavlov. Cond. magazine entry latency0.10.10.3-0.6-0.2-0.3-0.2-0.2-0.5-0.4-0.3-0.3-0.50.1
Pavlov. Cond. change in total contacts0.20.31.70.80.70.70.51.3-0.2-0.0-0.1-0.1-0.30.1
Pavlov. Cond. index score0.10.10.30.30.20.10.10.6-0.4-0.3-0.4-0.3-0.50.2
Pavlov. Cond. latency score0.10.10.60.40.40.40.20.8-0.2-0.1-0.2-0.2-0.30.4
Pavlov. Cond. lever contacts0.20.21.01.00.50.5-0.10.90.1-0.2-0.3-0.2-0.10.2
Pavlov. Cond. magazine entry number0.00.00.30.1-0.1-0.00.10.20.00.00.0-0.10.0-0.5
Pavlov. Cond. intertrial magazine entries1.11.62.6-1.1-1.5-1.3-0.7-0.5-1.5-1.2-1.2-1.5-1.4-1.6
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.30.20.20.00.5-0.3-0.3-0.3-0.3-0.40.2
Pavlov. Cond. response bias0.20.20.50.2-0.1-0.2-0.50.2-0.5-0.7-0.7-0.6-0.6-0.1
Time in closed arm before self-admin0.10.10.3-0.3-0.0-0.00.50.6-0.10.20.30.1-0.10.4
Time in closed arm after self-admin0.10.10.3-0.20.30.20.40.00.30.50.50.40.30.6
Time in open arm before self-admin1.01.12.2-0.2-0.6-0.7-0.8-0.1-1.3-1.3-1.3-1.3-1.4-1.5
Time in open arm after self-admin0.20.20.60.20.30.30.10.8-0.4-0.4-0.4-0.4-0.4-0.5
Bone: periosteal estimation0.61.34.8-1.00.80.72.21.00.21.31.41.10.61.1
Bone: periosteal perimeter0.20.31.9-1.4-0.4-0.50.6-0.0-0.8-0.10.1-0.2-0.5-0.1
Bone: post-yield work0.40.52.7-1.6-0.2-0.40.5-0.8-0.00.50.60.70.20.9
Progressive ratio test 1 active lever presses0.00.00.1-0.10.10.20.1-0.30.2-0.10.10.20.10.2
Progressive ratio test 1 breakpoint0.00.00.1-0.10.10.20.2-0.30.2-0.10.10.20.10.2
Progressive ratio test 1 inactive lever presses0.30.41.20.60.40.5-0.2-0.61.10.60.50.70.80.8
Progressive ratio test 2 active lever presses0.30.30.90.3-0.4-0.3-1.0-0.4-0.2-0.7-0.7-0.6-0.5-0.8
Progressive ratio test 2 breakpoint0.30.41.00.5-0.4-0.2-1.0-0.3-0.2-0.7-0.8-0.7-0.5-0.8
Progressive ratio test 2 inactive lever presses0.20.30.9-0.9-0.6-0.4-0.1-1.0-0.4-0.4-0.1-0.3-0.4-0.2
Incentive Sensitization - Responses0.71.02.00.0-0.9-0.7-1.2-0.3-1.0-1.1-1.3-1.3-1.1-1.4
Incentive Sensitization - Breakpoint0.70.91.80.2-0.8-0.7-1.3-0.4-0.8-1.0-1.2-1.2-0.9-1.3
Sum of active levers in priming session hrs 5-60.10.10.3-0.5-0.0-0.10.3-0.1-0.4-0.4-0.2-0.3-0.5-0.2
Progressive ratio3.96.18.62.22.92.82.52.92.02.72.32.22.32.1
Food seeking constrained by brief footshock0.10.20.50.70.70.70.20.50.10.00.10.10.10.0
Seeking ratio, punishment vs. effort2.84.05.4-1.6-2.1-2.1-1.8-2.0-2.0-2.3-2.0-2.0-2.1-1.9
Retroperitoneal fat weight0.20.82.50.40.30.3-0.3-0.81.60.60.71.01.21.4
Reaction time number correct1.52.94.02.02.01.91.21.62.01.61.51.61.71.3
Reaction time mean minus median1.12.73.8-1.8-1.9-2.0-1.3-1.4-1.8-1.7-1.6-1.4-1.6-1.3
Reaction time mean minus median AUC1.12.73.9-1.9-2.0-1.9-1.5-1.8-1.5-1.8-1.6-1.4-1.6-1.1
Reaction time num false alarms0.50.71.5-0.7-0.7-0.8-0.3-0.4-1.2-0.7-0.8-1.0-1.0-1.2
Reaction time num false alarms AUC0.60.92.4-0.7-0.7-0.7-0.00.1-1.5-0.8-0.9-1.1-1.2-1.3
Reaction time trials correct on left1.52.94.02.02.01.91.21.62.01.61.51.61.71.3
Reaction time trials on left1.52.93.91.92.01.91.21.62.01.61.51.61.71.4
Reaction time mean1.82.87.2-2.7-2.2-2.2-1.3-2.5-1.3-1.3-1.0-0.8-1.1-0.5
Reaction time mean AUC1.72.76.5-2.5-2.1-2.2-1.3-2.4-1.2-1.3-1.1-0.9-1.1-0.5
Median of all reaction times1.31.85.7-2.4-1.7-1.8-0.9-2.3-0.7-0.8-0.5-0.4-0.6-0.1
Reaction time omissions1.11.63.7-1.9-1.6-1.7-0.8-1.8-1.1-0.9-0.8-0.7-0.9-0.4
Reaction time false alarm rate2.33.26.7-1.8-1.7-1.7-0.7-0.8-2.6-1.7-1.7-2.0-2.1-2.0
Reaction time premature initiation rate0.70.91.6-0.00.70.91.00.11.01.11.21.11.01.3
Reaction time premature initiations1.93.44.41.21.82.01.71.02.12.02.12.02.02.0
Std. dev. reaction times1.73.25.5-2.3-2.1-2.1-1.0-1.5-2.2-1.8-1.6-1.6-1.9-1.2
Reaction time trials completed1.52.93.91.92.01.91.21.62.01.61.51.61.71.4
Reaction time trials AUC1.42.74.01.91.91.81.11.52.01.61.51.71.71.3
Run reversals in cocaine runway, females0.60.61.00.80.91.00.10.31.00.70.60.80.80.8
Run reversals in cocaine runway, males0.40.41.2-1.1-0.8-0.8-0.3-0.6-0.7-0.5-0.5-0.5-0.6-0.5
Latency to leave start box in cocaine runway1.21.43.1-1.6-1.4-1.5-0.9-1.8-1.1-0.9-0.8-0.7-0.8-0.5
Latency to leave start box in cocaine runway, F1.01.13.1-1.3-1.2-1.3-1.0-1.8-1.0-0.9-0.8-0.6-0.7-0.6
Latency to leave start box in cocaine runway, M0.20.10.6-0.8-0.6-0.6-0.1-0.5-0.4-0.1-0.1-0.2-0.10.1
Std. dev. time between licks in bursts1.11.56.6-2.6-1.2-1.30.3-0.8-1.7-0.6-0.4-0.7-1.2-0.5
Total sessions with >9 infusions0.10.10.30.50.50.50.20.50.0-0.2-0.1-0.2-0.2-0.4
Short access day 1 total inactive lever presses0.20.31.3-1.1-0.2-0.30.4-0.9-0.5-0.30.0-0.1-0.3-0.2
Short access day 10 total inactive lever presses0.30.82.1-0.9-1.2-1.1-1.2-1.5-0.6-0.5-0.8-0.7-0.4-0.6
Short access day 1 total infusions0.10.10.3-0.3-0.1-0.10.0-0.4-0.3-0.5-0.1-0.3-0.4-0.3
Short access day 10 total infusions0.10.10.20.40.10.2-0.4-0.20.2-0.4-0.3-0.2-0.0-0.1
Short access total infusions0.00.00.10.10.20.3-0.0-0.30.1-0.3-0.0-0.1-0.1-0.2
Short access day 1 locomotion1.11.42.0-0.7-1.4-1.2-1.4-1.3-0.9-1.2-1.3-1.1-1.0-1.2
Short access day 10 total locomotion0.40.83.0-0.40.50.71.70.70.11.01.00.90.51.1
Short access total locomotion0.10.10.4-0.6-0.10.00.5-0.40.10.30.40.50.20.4
One hour access (0.3 mA shock)2.22.54.7-0.4-1.6-1.6-2.2-1.2-1.3-1.6-1.9-1.8-1.4-1.7
Compulsive drug intake3.44.07.7-2.3-2.8-2.7-1.8-2.6-1.8-1.3-1.5-1.5-1.3-1.5
One hour access (shock baseline)0.30.52.21.50.90.8-0.40.90.6-0.2-0.2-0.10.1-0.1
Social response proportion0.40.41.7-0.70.30.31.30.00.20.60.90.60.50.6
Social responses0.20.21.3-0.20.40.31.20.5-0.20.30.40.10.10.0
Social time2.02.85.6-2.4-2.1-2.1-0.9-2.0-1.8-1.3-1.4-1.3-1.3-1.0
Soleus weight0.72.113.4-3.7-1.3-1.40.9-1.6-1.30.10.50.1-0.70.3
Bone: stiffness0.50.91.70.90.90.70.30.31.31.00.91.11.21.1
Tibialis anterior weight0.10.51.81.30.70.70.00.21.00.50.40.50.70.7
Time to tail flick, vehicle, before self-admin0.90.92.5-0.0-1.3-1.3-1.6-0.9-0.4-0.7-1.0-0.9-0.5-0.8
Time to tail flick, vehicle, after self-admin0.60.81.2-0.8-1.1-1.1-0.6-0.5-1.0-1.0-0.9-1.0-1.0-0.7
Time to tail flick, test, before self-admin0.40.40.80.9-0.1-0.0-0.60.6-0.5-0.5-0.8-0.8-0.6-0.9
Time to tail flick, test, after self-admin1.71.72.90.1-0.9-0.9-1.6-0.3-1.3-1.5-1.7-1.7-1.5-1.7
Delta time to tail flick, vehicle, before/after SA0.20.20.6-0.1-0.0-0.1-0.2-0.2-0.4-0.8-0.5-0.5-0.6-0.5
Delta time to tail flick, test, before/after SA0.20.20.7-0.2-0.3-0.3-0.8-0.90.2-0.2-0.20.00.10.0
Tibia length1.02.86.4-1.41.01.02.50.61.12.12.31.81.32.0
Ambulatory time before self-admin0.00.00.2-0.1-0.3-0.2-0.2-0.40.20.10.10.30.10.1
Ambulatory time after self-admin0.60.72.00.30.80.91.41.20.10.90.80.60.50.5
Bone: tissue strength0.50.50.90.00.50.50.6-0.31.00.70.91.00.91.0
Total heroin consumption0.10.10.2-0.2-0.3-0.3-0.20.0-0.3-0.3-0.4-0.2-0.4-0.4
Bone: trabecular number0.61.05.60.7-0.8-0.8-2.4-1.00.2-0.8-1.0-0.6-0.2-0.8
Bone: trabecular spacing1.11.56.3-0.41.01.12.51.20.31.21.40.90.61.0
Bone: trabecular thickness0.40.42.90.5-0.4-0.5-1.7-0.90.5-0.3-0.40.00.2-0.2
Bone: trabecular tissue density0.30.41.40.50.70.60.61.2-0.8-0.1-0.2-0.4-0.6-0.6
Water consumed over 24 hours0.20.20.6-0.8-0.6-0.6-0.0-0.5-0.5-0.4-0.3-0.3-0.4-0.2
Number of responses in last shaping day0.50.61.9-1.4-0.2-0.31.30.3-1.2-0.20.1-0.3-0.7-0.5