Hub : Genes

Hspa1a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Hspa1a 0.3 0.2 2.0e-03 0.02 0.07 0.05 0.07 9.2e-02 1.0e-02 2.6e-02 9.9e-03
2 PL gene expression Hspa1a 0.22 0.1 0.0e+00 0.22 0.21 0.2 0.22 2.8e-24 1.3e-22 6.4e-21 9.0e-24
3 OFC gene expression Hspa1a 0.17 0.1 2.6e-03 0.12 0.08 0.05 0.13 9.3e-04 5.4e-03 2.4e-02 4.9e-04
4 IL gene expression Hspa1a 0.26 0.13 4.8e-05 0.19 0.12 0.15 0.2 2.0e-05 7.2e-04 2.4e-04 1.3e-05
5 Adipose gene expression Hspa1a 0.11 0.05 6.9e-13 0.08 0.11 0.12 0.11 5.6e-09 1.9e-12 8.8e-13 3.4e-12
6 IC gene expression Hspa1a 0.33 0.12 8.3e-10 0.24 0.17 0.15 0.18 2.7e-10 1.1e-07 5.7e-07 3.1e-08
7 Liver gene expression Hspa1a 0.26 0.08 0.0e+00 0.21 0.25 0.28 0.28 1.6e-22 5.8e-28 1.2e-30 2.8e-31
8 NAcc gene expression Hspa1a 0.17 0.07 0.0e+00 0.12 0.14 0.14 0.15 1.8e-18 3.1e-21 1.2e-20 1.2e-21
9 Brain gene expression Hspa1a 0.29 0.09 0.0e+00 0.21 0.24 0.25 0.25 1.1e-19 1.6e-22 2.7e-23 3.4e-23
10 pVTA gene expression Hspa1a 0.18 0.1 5.8e-09 0.08 0.09 0.09 0.08 7.0e-07 1.0e-07 1.8e-07 3.7e-07
11 BLA gene expression Hspa1a 0.21 0.1 1.2e-07 0.15 0.14 0.13 0.15 2.9e-08 4.6e-08 2.0e-07 1.9e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.40.74.10.50.7-0.7-2.01.0-0.2-0.7-0.80.4-0.2-0.6
Area under the delay curve0.10.10.3-0.50.1-0.00.4-0.10.6-0.4-0.20.4-0.3-0.3
BMI with tail1.86.310.62.2-2.22.21.5-1.1-3.32.72.6-2.93.03.1
BMI without tail1.68.311.02.6-3.23.33.0-3.1-2.83.02.8-2.72.62.6
Body weight2.912.618.21.6-3.33.33.9-2.3-3.54.14.3-4.23.74.0
Weight adjusted by age1.33.97.90.1-1.61.72.8-1.0-1.42.22.6-2.31.82.5
Bone surface0.00.00.0-0.10.1-0.2-0.10.20.00.20.1-0.20.00.2
Bone volume0.10.10.30.6-0.10.1-0.40.2-0.50.30.2-0.40.40.3
Breakpoint value in progressive ratio session0.30.51.0-0.50.5-0.6-0.50.20.8-0.8-0.90.8-0.8-1.0
Number of licking bursts0.51.63.1-1.81.4-1.6-0.60.91.6-1.1-1.11.1-1.3-1.3
Context. condit. distance diff. score4.65.69.5-3.13.0-3.0-2.12.92.0-2.1-1.91.7-1.9-1.5
Locomotion velocity, session 11.11.21.9-1.41.0-1.0-0.60.11.2-1.3-1.01.2-1.4-1.1
Locomotion distance, session 10.60.82.7-0.21.0-1.0-1.70.70.3-1.0-1.00.8-0.6-0.8
Locomotion velocity, session 21.01.21.8-1.31.3-1.2-0.80.61.2-1.2-1.01.2-1.1-0.9
Locomotion distance, session 21.21.73.6-1.21.7-1.6-1.91.90.5-1.3-1.10.9-0.7-0.6
Locomotion velocity, session 30.20.20.80.8-0.50.50.2-0.9-0.4-0.1-0.20.2-0.0-0.0
Locomotion distance, session 31.61.83.2-0.51.4-1.4-1.81.10.9-1.6-1.61.5-1.2-1.2
Stereotopy head waving bouts, day 30.20.31.4-0.7-0.30.21.2-0.70.30.40.4-0.30.00.3
Stereotopy head waving duration, day 30.70.93.3-0.1-1.01.01.8-1.60.10.80.8-0.50.20.3
Locomotion velocity, session 73.94.39.6-1.62.4-2.3-3.03.10.9-2.2-2.01.6-1.2-1.2
Locomotion distance, session 74.45.710.5-1.52.5-2.5-3.22.81.6-2.7-2.62.3-1.9-1.8
Stereotopy head waving bouts, day 70.60.73.60.1-0.50.30.6-1.91.0-0.4-0.50.8-1.0-0.8
Stereotopy head waving duration, day 70.50.64.30.4-0.70.60.9-2.10.40.10.00.2-0.3-0.4
Locomotion velocity, session 83.03.69.6-3.12.3-2.3-0.71.32.2-1.6-1.31.6-1.9-1.3
Locomotion distance, session 84.97.114.8-3.23.5-3.5-2.93.81.6-2.4-2.11.7-1.7-1.3
Degree of sensitization distance0.50.51.7-1.30.8-0.8-0.21.10.7-0.5-0.40.3-0.5-0.1
Degree of sensitization stereotypy0.80.92.00.00.1-0.2-0.2-1.41.1-0.8-1.01.1-1.2-1.3
Conditioned locomotion0.50.51.1-0.0-0.30.30.80.4-0.60.90.9-1.00.91.0
Cocaine response after cond. corrected0.60.95.5-0.81.1-1.1-1.12.4-0.1-0.2-0.1-0.20.30.5
Cocaine response after cond. not corrected0.20.31.1-0.90.6-0.60.11.00.20.10.2-0.20.10.4
Cocaine response before conditioning1.72.19.00.3-1.41.52.7-3.00.11.11.1-0.50.10.1
Saline control response4.66.411.03.0-3.23.32.4-3.3-1.92.42.1-1.91.91.8
Bone: connectivity density0.30.52.60.10.8-0.7-1.61.1-0.3-0.3-0.4-0.00.1-0.0
Bone: cortical apparent density1.21.93.71.9-1.51.50.6-0.7-1.71.31.2-1.41.61.4
Bone: cortical area0.00.00.1-0.2-0.0-0.10.2-0.40.00.10.1-0.00.00.2
Bone: cortical porosity1.11.23.1-0.3-0.30.30.5-1.81.5-1.0-1.01.3-1.5-1.4
Bone: cortical porosity1.21.32.8-0.8-0.00.10.5-1.61.7-1.0-0.91.3-1.6-1.3
Bone: cortical thickness0.40.72.51.6-0.90.8-0.1-1.2-1.00.50.3-0.50.80.5
Bone: cortical thickness1.31.53.51.9-1.31.30.2-1.5-1.61.00.7-0.91.20.9
Bone: cortical tissue density1.21.93.31.8-1.51.40.6-0.7-1.71.31.2-1.41.51.3
Condit. Reinf. active minus inactive responses1.11.32.4-0.60.8-0.7-0.9-0.11.1-1.5-1.51.5-1.3-1.3
Condit. Reinf. active-inactive response ratio0.20.21.50.6-0.40.50.2-1.2-0.0-0.2-0.30.4-0.1-0.3
Condit. Reinf. active responses0.81.12.0-0.50.9-0.8-1.40.80.6-1.4-1.31.3-0.9-1.0
Condit. Reinf. inactive responses1.01.34.30.00.9-1.0-2.11.70.1-1.2-1.20.8-0.5-0.9
Incentive salience index mean2.93.84.9-2.02.2-2.1-1.81.81.7-2.2-2.02.0-1.8-1.6
Condit. Reinf. lever presses3.95.813.7-2.83.0-3.0-2.43.71.7-2.1-1.81.6-1.6-1.4
Condit. Reinf. active minus inactive responses0.40.61.80.3-0.90.91.3-1.2-0.20.60.7-0.30.20.3
Condit. Reinf. active-inactive response ratio0.40.62.8-0.2-0.70.81.7-1.10.10.70.8-0.40.10.5
Condit. Reinf. active responses0.20.20.80.6-0.60.60.7-0.9-0.20.30.3-0.10.10.1
Condit. Reinf. inactive responses0.10.20.90.9-0.40.3-0.2-0.5-0.50.1-0.1-0.10.30.0
Condit. Reinf. lever presses0.10.20.40.10.10.0-0.2-0.50.5-0.5-0.60.6-0.7-0.4
Condit. Reinf. lever reinforcers received0.10.20.80.4-0.40.40.5-0.90.20.0-0.00.2-0.2-0.2
Conditioned reinforcement - actives0.00.20.30.5-0.40.60.2-0.1-0.60.30.3-0.30.40.4
Conditioned reinforcement - inactives0.10.20.60.3-0.80.80.5-0.2-0.50.40.5-0.40.40.2
Conditioned locomotion0.10.10.2-0.2-0.20.30.30.1-0.40.20.4-0.40.20.3
Patch foraging indifference point 0 sec1.33.86.32.1-2.52.41.7-2.3-1.71.81.8-1.61.71.5
Patch foraging indifference point AUC0.10.31.1-0.2-0.10.20.3-1.01.0-0.3-0.30.6-0.7-0.6
Delay disc. indifference point, 0s delay0.40.51.9-1.10.7-0.7-0.11.40.7-0.5-0.20.3-0.4-0.2
Delay disc. indifference point, 16s delay0.10.10.40.4-0.50.50.1-0.6-0.2-0.2-0.20.10.10.0
Delay disc. indifference point, 2s delay0.30.31.2-1.10.2-0.11.0-0.31.0-0.3-0.00.4-0.4-0.4
Delay disc. indifference point, 24s delay0.20.31.0-0.1-0.70.81.0-1.00.1-0.10.1-0.0-0.10.4
Delay disc. indifference point, 4s delay0.30.31.60.1-0.50.61.3-0.90.30.30.4-0.10.1-0.0
Delay disc. indifference point, 8s delay0.20.30.5-0.60.4-0.4-0.20.30.6-0.7-0.50.6-0.5-0.7
Indifference point function ln k0.31.01.3-1.10.9-1.1-0.50.61.1-1.1-1.11.1-1.1-1.2
Indifference point function log k0.31.01.3-1.10.9-1.1-0.50.61.1-1.1-1.11.1-1.1-1.2
Patch foraging total patch changes 0 sec1.33.96.52.2-2.62.51.7-2.3-1.71.81.8-1.61.71.5
Patch foraging total patch changes 12 sec1.72.34.81.8-1.91.91.3-2.2-0.91.31.2-1.01.01.2
Patch foraging total patch changes 18 sec1.22.75.82.4-1.92.00.4-1.5-1.91.51.3-1.41.71.2
Patch foraging total patch changes 24 sec0.20.62.31.5-1.01.0-0.5-0.7-0.90.30.2-0.50.70.4
Patch foraging total patch changes 6 sec1.83.15.02.1-2.22.21.3-2.2-1.51.61.6-1.41.51.5
Patch foraging time to switch 0 sec0.52.14.91.1-0.70.70.10.8-2.21.41.4-1.92.02.0
Patch foraging water rate 0 sec0.00.10.3-0.1-0.60.40.5-0.2-0.20.40.5-0.40.30.4
Patch foraging water rate 12 sec0.00.10.50.7-0.20.0-0.7-0.2-0.2-0.2-0.40.20.0-0.5
Patch foraging water rate 18 sec0.20.40.70.6-0.90.50.4-0.7-0.60.50.4-0.60.50.6
Patch foraging water rate 24 sec0.20.31.21.1-0.70.40.1-0.5-0.50.40.2-0.30.40.1
Patch foraging water rate 6 sec0.00.10.30.5-0.30.1-0.2-0.0-0.2-0.0-0.1-0.00.2-0.5
Seeking ratio, delayed vs. immediate footshock0.60.94.61.3-0.90.80.9-2.20.40.4-0.00.3-0.2-0.5
Distance traveled before self-admin0.20.40.8-0.10.2-0.20.10.8-0.60.70.7-0.90.70.9
Distance traveled after self-admin0.61.02.20.7-0.90.91.5-1.2-0.41.31.1-0.90.80.9
Extensor digitorum longus weight0.10.20.7-0.70.2-0.20.50.9-0.10.30.4-0.50.10.5
Bone: elastic displacement0.10.10.40.4-0.50.6-0.1-0.70.0-0.3-0.20.3-0.2-0.5
Bone: elastic work0.10.10.30.1-0.50.60.4-0.5-0.30.30.4-0.30.30.1
Bone: endosteal estimation0.82.08.8-1.2-0.90.73.0-0.8-0.01.61.8-1.30.61.4
Bone: endosteal perimeter0.30.84.7-2.20.9-1.00.90.90.90.10.3-0.0-0.50.1
Epididymis fat weight3.316.833.45.6-4.34.31.2-1.7-5.83.83.3-4.04.93.6
Delta time in closed arm before/after self-admin0.80.71.3-0.0-0.50.50.90.5-0.71.01.1-1.21.01.1
Delta time in open arm before/after self-admin0.20.20.50.6-0.50.60.2-0.7-0.50.10.1-0.10.30.1
Diff in mean of infusions in LGA sessions1.52.85.9-1.02.0-2.0-2.42.10.7-1.5-1.61.4-1.2-1.3
Delay discount exponential model param0.10.20.40.4-0.0-0.1-0.50.4-0.70.40.3-0.40.40.4
Extinction: sum of active levers before priming0.50.71.4-1.21.1-1.1-0.40.91.0-0.8-0.60.6-0.8-0.5
Active lever presses in extinction session 60.10.10.20.1-0.40.5-0.10.2-0.4-0.20.0-0.30.20.1
Bone: final force1.93.04.01.3-1.61.61.3-1.2-2.02.01.9-2.02.02.0
Bone: final moment1.72.73.51.3-1.61.61.3-1.1-1.81.91.8-1.91.81.8
Food consumed during 24 hour testing period0.30.61.4-0.50.0-0.10.60.9-0.60.80.9-0.90.91.2
Glucose2.33.712.9-3.62.1-2.2-0.21.92.3-1.5-1.11.2-1.8-0.8
Heart weight1.21.96.30.2-1.61.62.5-1.8-0.41.31.5-1.00.70.9
Delay discount hyperbolic model param0.20.20.60.40.0-0.1-0.60.5-0.80.40.3-0.50.50.5
Intermittent access intake day 1-15 change0.00.20.80.50.10.1-0.3-0.90.2-0.1-0.30.4-0.4-0.4
Intermittent access intake escalation0.10.52.51.2-0.50.7-0.1-1.6-0.10.1-0.20.4-0.2-0.4
Intermittent access intake escalation 20.20.30.6-0.00.4-0.2-0.3-0.60.8-0.5-0.70.8-0.8-0.7
Intermitt. access day 1 inactive lever presses0.00.62.6-1.10.9-1.00.31.60.8-0.00.00.0-0.20.2
Intermitt. access day 15 inactive lever presses0.10.51.10.1-0.50.61.0-0.3-0.50.80.9-0.80.60.9
Intermitt. access escalation Index0.92.94.4-1.22.1-2.0-1.92.11.4-1.6-1.61.5-1.2-1.8
Intermittent access day 1 total infusions0.20.61.1-0.70.6-0.4-1.00.90.3-1.1-0.80.7-0.6-0.7
Intermittent access day 15 total infusions0.10.30.50.7-0.20.3-0.6-0.7-0.0-0.5-0.60.6-0.4-0.6
Intermittent access terminal intake (last 3 days)0.10.20.90.6-0.60.70.1-0.9-0.0-0.2-0.20.3-0.2-0.3
Intermittent access total infusions0.10.10.20.3-0.30.4-0.1-0.3-0.2-0.4-0.30.3-0.2-0.4
Intermittent access day 1 locomotion0.10.20.60.4-0.20.3-0.30.5-0.80.20.2-0.50.40.4
Intermittent access day 15 total locomotion0.20.81.10.8-0.80.90.6-0.8-1.01.00.9-1.00.81.0
Intermittent access total locomotion0.40.50.90.9-0.80.90.4-0.5-1.00.60.6-0.70.60.6
Intermittent access standard deviation0.73.44.61.9-2.02.11.8-1.8-1.81.91.8-1.81.71.8
Left kidney weight1.613.015.72.8-3.73.83.9-2.9-3.54.03.9-3.83.53.6
Right kidney weight1.812.516.72.5-3.43.53.7-2.0-3.54.14.1-4.03.73.7
Cocaine induced anxiety0.10.31.0-0.60.9-0.8-0.31.00.4-0.3-0.30.2-0.2-0.0
Post-drug Anxiety0.10.10.30.10.10.10.50.1-0.00.40.3-0.20.30.2
Baseline Anxiety0.10.20.70.3-0.50.50.6-0.8-0.30.50.5-0.30.3-0.2
Tail length0.63.414.5-0.4-1.71.83.8-2.6-0.01.82.0-1.30.51.0
Length with tail1.25.517.6-0.5-2.02.04.2-1.8-1.02.73.1-2.41.72.4
Length without tail1.47.213.1-0.1-1.71.63.10.3-2.53.23.6-3.63.03.6
Times rat made contact with spout0.80.91.61.0-0.1-0.0-1.2-0.90.3-1.1-1.31.2-0.8-1.2
Lifetime Intake0.00.10.20.2-0.40.50.0-0.2-0.2-0.2-0.10.2-0.1-0.3
Liver weight, left0.40.72.0-1.10.0-0.01.40.3-0.10.91.1-1.00.51.1
Liver weight, right0.40.73.5-1.90.4-0.31.40.50.60.40.7-0.6-0.10.9
Locomotor activity0.40.62.70.0-0.70.61.6-1.70.50.40.5-0.1-0.10.0
Locomotor testing distance0.10.31.2-0.3-0.40.41.1-0.60.10.50.6-0.30.20.3
Locomotor testing rearing0.31.02.00.1-0.80.81.4-0.4-0.81.31.4-1.20.91.1
Locomotion in novel chamber0.00.10.40.6-0.30.10.1-0.30.10.20.10.00.2-0.2
Locomotion in novel chamber post-restriction0.72.12.91.1-1.51.51.4-1.0-1.51.71.7-1.41.51.3
Fecal boli incidents, locomotor time 10.10.30.70.1-0.30.40.10.7-0.80.40.6-0.70.80.5
Change in fecal boli incidents, locomotor task0.20.30.9-1.00.5-0.60.70.40.80.20.20.0-0.30.2
Time >=10cm from walls, locomotor time 11.31.63.2-0.1-0.50.51.60.6-1.01.61.7-1.71.51.8
Bouts of movement, locomotor time 10.81.01.6-0.61.1-1.0-1.20.50.9-1.2-1.31.1-1.0-0.9
Total resting periods, locomotor time 10.60.71.1-0.61.0-1.0-1.00.50.8-1.0-1.00.9-0.8-0.6
Rest time, locomotor task time 10.00.00.2-0.4-0.1-0.00.50.00.4-0.00.00.1-0.20.0
Distance moved, locomotor task time 10.10.20.30.2-0.40.40.4-0.5-0.50.40.4-0.50.40.3
Vertical activity count, locomotor time 10.10.71.10.8-0.80.80.4-0.8-0.90.90.9-0.91.00.5
Time >=10cm from walls, locomotor time 20.41.22.9-0.6-0.50.61.70.2-0.61.41.7-1.41.11.2
Bouts of movement, locomotor time 20.10.41.00.00.1-0.00.2-0.81.0-0.5-0.70.8-0.7-0.7
Total resting periods, locomotor time 20.20.82.3-0.40.4-0.40.2-0.71.5-0.9-1.01.1-1.1-1.0
Rest time, locomotor task time 20.50.92.7-1.41.2-1.4-0.41.60.9-0.4-0.40.3-0.4-0.0
Distance moved, locomotor task time 21.11.52.80.7-1.21.30.7-0.7-1.71.11.4-1.51.31.3
Vertical activity count, locomotor time 20.61.31.90.6-1.21.10.9-0.6-1.31.11.4-1.41.31.3
Light reinforcement 10.20.71.30.6-0.10.30.10.5-1.21.00.9-1.11.11.0
Light reinforcement 20.30.61.4-0.20.2-0.10.11.0-1.10.70.8-1.00.91.2
Bone: marrow area1.02.49.8-1.1-1.10.93.1-0.9-0.21.82.0-1.50.81.5
Bone: maximum diameter0.71.34.4-2.11.4-1.5-0.10.81.4-0.9-0.70.8-1.1-0.6
Bone: maximum force1.01.93.00.9-1.31.11.2-0.7-1.61.61.5-1.71.61.7
Bone: maximum moment0.91.72.50.8-1.31.11.2-0.7-1.41.51.5-1.51.41.6
Mean time between licks in bursts0.32.04.8-2.21.5-1.6-0.41.11.9-1.2-1.01.2-1.5-1.3
Mean num. licks in bursts0.51.44.92.2-1.41.50.1-1.5-1.40.60.4-0.50.80.6
Cd content in liver0.70.82.30.5-0.40.3-0.50.8-1.50.70.8-1.11.31.1
Co content in liver2.12.54.01.2-1.51.51.2-1.0-2.01.61.7-1.81.81.9
Cu content in liver0.91.12.91.00.4-0.5-1.70.20.3-1.2-1.61.3-0.7-1.1
Fe content in liver1.21.52.21.5-1.41.40.8-0.3-1.31.31.2-1.41.41.1
K content in liver0.80.71.4-0.41.0-1.1-1.20.90.6-0.9-1.00.7-0.7-0.5
Mg content in liver2.52.84.9-1.92.2-2.2-1.41.61.6-1.5-1.51.4-1.5-1.0
Mn content in liver2.12.47.6-2.82.0-2.0-0.62.41.1-1.0-0.80.7-1.0-0.6
Na content in liver0.50.61.20.60.3-0.3-0.7-0.20.9-0.7-1.01.0-0.8-1.1
Rb content in liver0.30.42.1-0.20.4-0.4-0.81.4-0.20.20.1-0.40.30.8
Se content in liver4.14.87.4-2.72.3-2.2-1.00.92.6-2.4-2.22.5-2.5-2.0
Sr content in liver0.60.50.9-0.3-0.70.60.9-0.1-0.70.80.9-0.90.71.0
Zn content in liver0.10.10.3-0.60.3-0.30.00.30.0-0.00.0-0.1-0.10.5
Bone: minimum diameter0.30.63.5-1.90.6-0.70.80.70.50.20.5-0.3-0.20.4
Time in familiar zone, hab. session 10.50.61.91.2-0.20.2-1.4-0.6-0.0-0.8-0.90.8-0.4-0.6
Time in novel zone, hab. session 10.70.73.0-0.7-0.30.41.7-0.2-0.21.01.2-1.00.60.8
Total zone transitions, hab. session 10.40.61.0-0.51.0-0.9-1.00.60.7-0.8-0.80.7-0.7-0.6
Total locomotion distance, hab. session 10.40.61.2-0.50.9-1.0-1.11.10.4-0.7-0.70.5-0.5-0.3
Locomotion velocity, hab. session 10.20.30.7-0.40.7-0.7-0.80.60.4-0.6-0.60.5-0.5-0.3
Time in familiar zone, hab. session 20.30.31.61.3-0.50.5-0.2-1.1-0.40.2-0.10.00.20.3
Time in novel zone, hab. session 20.10.10.4-0.3-0.40.40.7-0.10.00.30.5-0.40.20.1
Total zone transitions, hab. session 20.10.20.80.10.6-0.5-0.70.9-0.1-0.0-0.1-0.00.20.1
Total locomotion distance, hab. session 20.71.03.4-0.41.3-1.3-1.61.90.3-0.6-0.70.4-0.2-0.3
Locomotion velocity, hab. session 21.31.74.7-0.81.7-1.7-1.92.20.6-1.0-1.10.8-0.6-0.7
Novel to familiar place preference ratio0.20.20.4-0.20.1-0.2-0.30.40.7-0.5-0.50.5-0.6-0.6
Novelty place preference0.10.20.6-0.30.0-0.1-0.00.10.8-0.4-0.40.5-0.6-0.6
Time in novel zone, NPP test0.10.20.6-0.2-0.10.10.2-0.20.8-0.3-0.30.4-0.6-0.6
Total zone transitions, NPP test0.91.33.0-0.91.5-1.5-1.71.50.6-1.0-0.90.8-0.7-0.6
Total locomotion distance, NPP test0.71.04.6-0.61.2-1.2-1.62.1-0.2-0.6-0.40.10.00.1
Locomotion velocity, NPP test1.21.76.9-0.81.6-1.6-2.12.60.0-0.9-0.80.4-0.2-0.2
Intraocular pressure0.20.20.80.8-0.30.4-0.40.1-0.90.20.3-0.50.50.5
Delta distance traveled before/after self-admin1.11.25.20.7-1.41.41.7-2.30.20.60.6-0.10.10.0
Delta ambulatory time before/after self-admin0.50.83.50.4-1.11.01.5-1.90.40.50.40.0-0.00.0
Parametrial fat weight2.04.710.01.8-1.61.80.8-0.1-3.22.32.2-2.62.72.8
Pavlov. Cond. lever latency5.77.29.63.1-3.02.91.9-2.4-2.92.72.4-2.62.82.5
Pavlov. Cond. magazine entry latency3.95.07.8-2.32.0-1.9-1.20.72.8-2.4-2.32.5-2.7-2.7
Pavlov. Cond. change in total contacts2.12.33.6-1.61.3-1.3-0.60.51.9-1.6-1.61.8-1.8-1.8
Pavlov. Cond. index score5.87.49.7-3.12.8-2.8-1.82.03.1-2.8-2.62.8-3.0-2.8
Pavlov. Cond. latency score6.17.810.4-3.22.9-2.9-1.82.13.2-2.9-2.72.8-3.1-2.9
Pavlov. Cond. lever contacts4.85.79.5-3.12.8-2.7-1.72.72.5-2.3-1.92.0-2.3-2.0
Pavlov. Cond. magazine entry number2.63.34.81.9-1.61.61.0-0.6-2.22.01.9-2.02.12.2
Pavlov. Cond. intertrial magazine entries1.11.33.31.7-1.10.9-0.20.0-1.80.80.7-1.11.41.1
Pavlov. Cond. lever-magazine prob. diff.5.97.39.4-3.12.8-2.8-1.82.03.0-2.8-2.62.8-2.9-2.8
Pavlov. Cond. response bias4.15.16.8-2.62.3-2.3-1.51.62.5-2.4-2.22.3-2.4-2.4
Pavlov. Cond. lever latency0.20.20.8-0.80.4-0.50.20.90.00.30.4-0.30.2-0.1
Pavlov. Cond. magazine entry latency0.10.10.5-0.70.2-0.3-0.20.20.5-0.4-0.30.3-0.50.1
Pavlov. Cond. change in total contacts0.10.31.70.7-0.70.70.5-1.30.2-0.0-0.10.1-0.30.1
Pavlov. Cond. index score0.10.10.30.1-0.20.10.1-0.60.4-0.3-0.40.3-0.50.2
Pavlov. Cond. latency score0.10.10.60.3-0.40.40.2-0.80.2-0.1-0.20.2-0.30.4
Pavlov. Cond. lever contacts0.10.20.70.8-0.50.5-0.1-0.9-0.1-0.1-0.30.2-0.10.2
Pavlov. Cond. magazine entry number0.00.00.30.10.1-0.00.1-0.2-0.00.00.00.10.0-0.5
Pavlov. Cond. intertrial magazine entries0.81.62.6-1.21.5-1.3-0.70.51.5-1.2-1.21.5-1.4-1.6
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.1-0.20.20.0-0.50.3-0.3-0.30.3-0.40.2
Pavlov. Cond. response bias0.10.20.50.00.1-0.2-0.5-0.20.5-0.7-0.70.6-0.6-0.1
Time in closed arm before self-admin0.10.10.3-0.30.0-0.00.5-0.60.10.20.3-0.1-0.10.4
Time in closed arm after self-admin0.10.10.30.1-0.30.20.4-0.0-0.30.50.5-0.40.30.6
Time in open arm before self-admin1.01.22.2-0.70.6-0.7-0.80.11.3-1.3-1.31.3-1.4-1.5
Time in open arm after self-admin0.20.20.60.1-0.30.30.1-0.80.4-0.4-0.40.4-0.4-0.5
Bone: periosteal estimation0.51.34.8-0.6-0.80.72.2-1.0-0.21.31.4-1.10.61.1
Bone: periosteal perimeter0.20.32.1-1.40.4-0.50.60.00.8-0.10.10.2-0.5-0.1
Bone: post-yield work0.20.40.9-0.90.2-0.40.50.80.00.50.6-0.70.20.9
Progressive ratio test 1 active lever presses0.00.00.1-0.3-0.10.20.10.3-0.2-0.10.1-0.20.10.2
Progressive ratio test 1 breakpoint0.00.00.1-0.3-0.10.20.20.3-0.2-0.10.1-0.20.10.2
Progressive ratio test 1 inactive lever presses0.20.51.20.8-0.40.5-0.20.6-1.10.60.5-0.70.80.8
Progressive ratio test 2 active lever presses0.20.30.9-0.00.4-0.3-1.00.40.2-0.7-0.70.6-0.5-0.8
Progressive ratio test 2 breakpoint0.30.41.00.10.4-0.2-1.00.30.2-0.7-0.80.7-0.5-0.8
Progressive ratio test 2 inactive lever presses0.10.31.1-1.00.6-0.4-0.11.00.4-0.4-0.10.3-0.4-0.2
Incentive Sensitization - Responses0.41.12.0-0.20.9-0.7-1.20.31.0-1.1-1.31.3-1.1-1.4
Incentive Sensitization - Breakpoint0.40.91.8-0.10.8-0.7-1.30.40.8-1.0-1.21.2-0.9-1.3
Sum of active levers in priming session hrs 5-60.10.10.4-0.70.0-0.10.30.10.4-0.4-0.20.3-0.5-0.2
Progressive ratio2.16.38.62.7-2.92.82.5-2.9-2.02.72.3-2.22.32.1
Food seeking constrained by brief footshock0.10.10.50.5-0.70.70.2-0.5-0.10.00.1-0.10.10.0
Seeking ratio, punishment vs. effort1.94.25.4-2.12.1-2.1-1.82.02.0-2.3-2.02.0-2.1-1.9
Retroperitoneal fat weight0.20.82.50.4-0.30.3-0.30.8-1.60.60.7-1.01.21.4
Reaction time number correct0.82.94.32.1-2.01.91.2-1.6-2.01.61.5-1.61.71.3
Reaction time mean minus median0.42.73.8-1.91.9-2.0-1.31.41.8-1.7-1.61.4-1.6-1.3
Reaction time mean minus median AUC0.42.84.3-2.12.0-1.9-1.51.81.5-1.8-1.61.4-1.6-1.1
Reaction time num false alarms0.50.81.5-1.00.7-0.8-0.30.41.2-0.7-0.81.0-1.0-1.2
Reaction time num false alarms AUC0.40.92.4-0.90.7-0.7-0.0-0.11.5-0.8-0.91.1-1.2-1.3
Reaction time trials correct on left0.82.94.32.1-2.01.91.2-1.6-2.01.61.5-1.61.71.3
Reaction time trials on left0.82.94.12.0-2.01.91.2-1.6-2.01.61.5-1.61.71.4
Reaction time mean1.32.86.7-2.62.2-2.2-1.32.51.3-1.3-1.00.8-1.1-0.5
Reaction time mean AUC1.12.76.2-2.52.1-2.2-1.32.41.2-1.3-1.10.9-1.1-0.5
Median of all reaction times1.11.75.1-2.21.7-1.8-0.92.30.7-0.8-0.50.4-0.6-0.1
Reaction time omissions0.91.53.3-1.71.6-1.7-0.81.81.1-0.9-0.80.7-0.9-0.4
Reaction time false alarm rate2.43.36.7-2.11.7-1.7-0.70.82.6-1.7-1.72.0-2.1-2.0
Reaction time premature initiation rate0.60.91.60.4-0.70.91.0-0.1-1.01.11.2-1.11.01.3
Reaction time premature initiations1.23.64.41.6-1.82.01.7-1.0-2.12.02.1-2.02.02.0
Std. dev. reaction times1.03.36.2-2.52.1-2.1-1.01.52.2-1.8-1.61.6-1.9-1.2
Reaction time trials completed0.82.94.12.0-2.01.91.2-1.6-2.01.61.5-1.61.71.4
Reaction time trials AUC0.82.84.01.9-1.91.81.1-1.5-2.01.61.5-1.71.71.3
Run reversals in cocaine runway, females0.50.61.11.1-0.91.00.1-0.3-1.00.70.6-0.80.80.8
Run reversals in cocaine runway, males0.40.40.9-0.90.8-0.8-0.30.60.7-0.5-0.50.5-0.6-0.5
Latency to leave start box in cocaine runway1.01.33.1-1.51.4-1.5-0.91.81.1-0.9-0.80.7-0.8-0.5
Latency to leave start box in cocaine runway, F0.91.13.1-1.11.2-1.3-1.01.81.0-0.9-0.80.6-0.7-0.6
Latency to leave start box in cocaine runway, M0.10.10.5-0.70.6-0.6-0.10.50.4-0.1-0.10.2-0.10.1
Std. dev. time between licks in bursts0.71.45.4-2.31.2-1.30.30.81.7-0.6-0.40.7-1.2-0.5
Total sessions with >9 infusions0.10.10.30.2-0.50.50.2-0.5-0.0-0.2-0.10.2-0.2-0.4
Short access day 1 total inactive lever presses0.10.31.3-1.10.2-0.30.40.90.5-0.30.00.1-0.3-0.2
Short access day 10 total inactive lever presses0.10.82.1-0.41.2-1.1-1.21.50.6-0.5-0.80.7-0.4-0.6
Short access day 1 total infusions0.10.10.5-0.70.1-0.10.00.40.3-0.5-0.10.3-0.4-0.3
Short access day 10 total infusions0.00.10.20.1-0.10.2-0.40.2-0.2-0.4-0.30.2-0.0-0.1
Short access total infusions0.00.00.1-0.2-0.20.3-0.00.3-0.1-0.3-0.00.1-0.1-0.2
Short access day 1 locomotion0.81.42.0-0.81.4-1.2-1.41.30.9-1.2-1.31.1-1.0-1.2
Short access day 10 total locomotion0.20.83.0-0.1-0.50.71.7-0.7-0.11.01.0-0.90.51.1
Short access total locomotion0.10.10.3-0.40.10.00.50.4-0.10.30.4-0.50.20.4
One hour access (0.3 mA shock)2.12.54.7-0.51.6-1.6-2.21.21.3-1.6-1.91.8-1.4-1.7
Compulsive drug intake2.63.87.7-1.82.8-2.7-1.82.61.8-1.3-1.51.5-1.3-1.5
One hour access (shock baseline)0.10.41.01.0-0.90.8-0.4-0.9-0.6-0.2-0.20.10.1-0.1
Social response proportion0.30.41.7-0.5-0.30.31.3-0.0-0.20.60.9-0.60.50.6
Social responses0.10.21.3-0.2-0.40.31.2-0.50.20.30.4-0.10.10.0
Social time1.72.64.5-2.02.1-2.1-0.92.01.8-1.3-1.41.3-1.3-1.0
Soleus weight0.61.79.6-3.11.3-1.40.91.61.30.10.5-0.1-0.70.3
Bone: stiffness0.50.91.71.0-0.90.70.3-0.3-1.31.00.9-1.11.21.1
Tibialis anterior weight0.20.52.41.5-0.70.70.0-0.2-1.00.50.4-0.50.70.7
Time to tail flick, vehicle, before self-admin0.70.92.5-0.11.3-1.3-1.60.90.4-0.7-1.00.9-0.5-0.8
Time to tail flick, vehicle, after self-admin0.40.91.2-1.01.1-1.1-0.60.51.0-1.0-0.91.0-1.0-0.7
Time to tail flick, test, before self-admin0.30.40.80.70.1-0.0-0.6-0.60.5-0.5-0.80.8-0.6-0.9
Time to tail flick, test, after self-admin1.61.72.9-0.10.9-0.9-1.60.31.3-1.5-1.71.7-1.5-1.7
Delta time to tail flick, vehicle, before/after SA0.20.20.6-0.50.0-0.1-0.20.20.4-0.8-0.50.5-0.6-0.5
Delta time to tail flick, test, before/after SA0.10.20.7-0.10.3-0.3-0.80.9-0.2-0.2-0.2-0.00.10.0
Tibia length0.92.66.4-0.5-1.01.02.5-0.6-1.12.12.3-1.81.32.0
Ambulatory time before self-admin0.00.00.2-0.10.3-0.2-0.20.4-0.20.10.1-0.30.10.1
Ambulatory time after self-admin0.40.72.00.4-0.80.91.4-1.2-0.10.90.8-0.60.50.5
Bone: tissue strength0.50.50.90.3-0.50.50.60.3-1.00.70.9-1.00.91.0
Total heroin consumption0.10.10.2-0.20.3-0.3-0.2-0.00.3-0.3-0.40.2-0.4-0.4
Bone: trabecular number0.51.05.60.50.8-0.8-2.41.0-0.2-0.8-1.00.6-0.2-0.8
Bone: trabecular spacing1.01.46.3-0.2-1.01.12.5-1.2-0.31.21.4-0.90.61.0
Bone: trabecular thickness0.30.42.90.50.4-0.5-1.70.9-0.5-0.3-0.4-0.00.2-0.2
Bone: trabecular tissue density0.20.41.40.1-0.70.60.6-1.20.8-0.1-0.20.4-0.6-0.6
Water consumed over 24 hours0.10.20.7-0.80.6-0.6-0.00.50.5-0.4-0.30.3-0.4-0.2
Number of responses in last shaping day0.50.62.1-1.50.2-0.31.3-0.31.2-0.20.10.3-0.7-0.5