Hub : Genes

Hnrnpr

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL intron excision ratio chr5_148543156_148548563 0.02 0.02 2.4e-03 0.03 0.01 0.01 0.01 7.7e-04 9.1e-03 2.3e-02 9.3e-03
2 Brain intron excision ratio chr5_148543156_148548563 0.03 0.03 1.5e-03 0.03 0.03 0.04 0.03 1.3e-03 1.8e-03 2.4e-04 1.1e-03
3 Brain isoform ratio XM_039110146.1 0.03 0.03 3.1e-03 0.02 0.02 0.02 0.02 9.0e-03 3.1e-03 6.5e-03 6.6e-03
4 LHb mRNA stability Hnrnpr 0.3 0.13 2.3e-09 0.34 0.36 0.38 0.39 8.8e-09 1.6e-09 4.4e-10 2.9e-10
5 NAcc mRNA stability Hnrnpr 0.2 0.1 0.0e+00 0.23 0.24 0.23 0.23 9.8e-27 3.5e-27 1.4e-26 6.6e-27
6 BLA mRNA stability Hnrnpr 0.27 0.15 7.2e-10 0.16 0.19 0.18 0.15 4.4e-09 2.1e-10 6.6e-10 1.9e-08
7 IL mRNA stability Hnrnpr 0.52 0.15 1.6e-10 0.35 0.39 0.36 0.34 3.6e-09 1.9e-10 1.9e-09 4.3e-09
8 Brain mRNA stability Hnrnpr 0.25 0.11 0.0e+00 0.32 0.32 0.31 0.32 3.4e-30 2.8e-30 9.8e-30 7.5e-31
9 PL mRNA stability Hnrnpr 0.16 0.07 0.0e+00 0.23 0.22 0.22 0.22 1.5e-24 4.6e-24 4.3e-24 3.1e-24
10 Liver mRNA stability Hnrnpr 0.08 0.06 7.4e-09 0.06 0.05 0.06 0.06 5.0e-07 3.0e-06 4.9e-07 9.7e-07
11 Adipose mRNA stability Hnrnpr 0.37 0.14 0.0e+00 0.32 0.31 0.3 0.31 1.4e-35 1.7e-34 5.0e-34 5.7e-35
12 pVTA mRNA stability Hnrnpr 0.35 0.15 3.8e-08 0.13 0.16 0.14 0.14 2.7e-06 1.2e-07 1.9e-06 8.5e-07
13 OFC mRNA stability Hnrnpr 0.43 0.15 2.3e-11 0.45 0.41 0.44 0.44 5.8e-12 6.1e-11 9.6e-12 1.3e-11
14 Adipose gene expression Hnrnpr 0.09 0.06 1.5e-11 0.08 0.07 0.06 0.07 1.9e-09 4.3e-08 1.1e-07 1.5e-08
15 Liver gene expression Hnrnpr 0.04 0.03 4.9e-06 0.03 0.03 0.07 0.03 2.8e-04 2.0e-04 6.2e-08 2.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.32.22.71.51.6-1.6-1.4-1.5-1.5-1.4-1.61.31.51.5-1.41.6-1.6-0.5
Area under the delay curve0.70.75.31.10.4-0.6-0.9-0.6-0.1-0.5-0.60.70.60.7-0.50.5-0.4-2.3
BMI with tail2.58.210.63.03.1-2.6-3.3-2.7-2.0-2.8-3.03.03.02.9-2.72.9-3.0-2.9
BMI without tail2.14.37.82.32.0-1.9-2.5-1.9-1.3-1.9-2.22.12.12.1-1.72.0-2.0-2.8
Body weight5.020.927.15.24.7-4.4-5.0-4.6-4.1-4.7-4.84.74.64.7-4.74.5-4.5-2.8
Weight adjusted by age0.10.10.4-0.40.00.40.10.20.20.00.3-0.2-0.2-0.10.1-0.20.20.6
Bone surface1.52.63.21.81.8-1.7-1.6-1.6-1.6-1.6-1.81.51.61.5-1.51.8-1.7-0.9
Bone volume1.22.02.61.61.5-1.6-1.4-1.4-1.3-1.3-1.61.41.41.4-1.31.6-1.5-0.7
Breakpoint value in progressive ratio session0.60.76.4-0.4-0.40.20.90.3-0.60.20.6-0.7-0.6-0.60.2-0.50.52.5
Number of licking bursts0.20.21.4-0.5-0.10.40.60.3-0.10.10.4-0.4-0.3-0.40.2-0.30.31.2
Context. condit. distance diff. score1.31.62.71.41.1-1.5-1.2-1.5-1.6-1.5-1.21.31.21.2-1.31.0-1.00.2
Locomotion velocity, session 10.60.71.10.80.7-1.1-0.8-0.9-0.9-0.8-0.80.90.81.0-0.80.8-0.8-0.4
Locomotion distance, session 10.00.00.10.1-0.1-0.1-0.2-0.00.20.1-0.10.0-0.00.00.30.00.10.2
Locomotion velocity, session 22.53.04.2-1.8-2.01.81.61.82.01.91.7-1.6-1.7-1.61.8-1.71.7-0.4
Locomotion distance, session 20.50.71.00.70.9-1.0-0.8-0.9-0.8-0.7-0.80.90.91.0-0.80.9-0.9-0.9
Locomotion velocity, session 30.60.72.8-0.8-0.50.51.10.60.00.50.8-0.8-0.8-1.00.6-0.70.81.7
Locomotion distance, session 31.01.12.01.01.4-1.2-1.0-1.2-1.3-1.2-1.00.90.90.9-0.81.0-1.00.2
Stereotopy head waving bouts, day 30.91.12.3-1.1-1.51.01.31.11.01.21.1-0.9-0.9-1.00.8-1.00.9-0.6
Stereotopy head waving duration, day 31.51.83.3-1.4-1.81.41.51.41.31.51.4-1.2-1.3-1.21.1-1.31.3-0.2
Locomotion velocity, session 71.31.42.31.11.5-1.4-1.1-1.4-1.5-1.3-1.11.11.11.1-1.11.1-1.10.2
Locomotion distance, session 70.20.30.80.30.6-0.6-0.3-0.5-0.7-0.5-0.40.40.30.4-0.40.4-0.30.9
Stereotopy head waving bouts, day 70.10.10.60.40.1-0.1-0.1-0.10.0-0.1-0.20.30.1-0.0-0.2-0.0-0.1-0.8
Stereotopy head waving duration, day 70.20.21.00.60.3-0.3-0.3-0.4-0.2-0.4-0.40.60.40.3-0.50.3-0.3-1.0
Locomotion velocity, session 80.30.30.80.70.5-0.6-0.5-0.5-0.4-0.5-0.60.60.50.5-0.60.5-0.5-0.9
Locomotion distance, session 82.02.94.01.91.8-2.0-1.7-1.9-2.0-1.9-1.71.81.61.6-1.71.4-1.5-0.2
Degree of sensitization distance1.41.42.7-1.2-1.61.31.21.31.41.41.3-1.1-1.2-1.00.9-1.21.20.2
Degree of sensitization stereotypy0.80.81.61.31.1-0.7-1.1-0.9-0.5-0.9-1.01.00.80.7-0.70.7-0.7-1.2
Conditioned locomotion2.63.14.6-1.6-1.41.81.61.92.22.01.6-1.9-1.8-1.92.1-1.61.70.8
Cocaine response after cond. corrected4.04.55.9-2.2-2.32.42.22.32.42.32.1-2.0-2.0-2.12.2-2.12.00.0
Cocaine response after cond. not corrected4.65.16.0-2.4-2.42.42.42.42.42.42.3-2.2-2.2-2.32.3-2.32.20.8
Cocaine response before conditioning0.40.50.90.70.8-0.9-0.7-0.8-1.0-0.8-0.70.50.60.7-0.60.6-0.70.6
Saline control response0.60.84.5-1.1-0.80.41.20.5-0.40.40.9-0.8-0.8-0.70.4-0.70.72.1
Bone: connectivity density0.50.81.61.01.3-0.9-0.9-0.9-1.0-0.9-1.00.70.80.7-0.80.9-0.90.0
Bone: cortical apparent density0.10.20.5-0.4-0.10.40.50.40.10.20.4-0.6-0.4-0.30.4-0.40.20.7
Bone: cortical area3.04.66.42.32.2-2.4-2.0-2.3-2.5-2.3-2.22.22.12.1-2.22.1-2.00.0
Bone: cortical porosity2.02.22.7-1.5-1.51.51.41.51.61.51.5-1.6-1.5-1.61.6-1.51.50.7
Bone: cortical porosity2.83.14.4-1.6-1.91.91.51.82.11.91.7-1.8-1.8-1.91.9-1.71.7-0.1
Bone: cortical thickness1.42.44.41.71.6-1.7-1.3-1.7-2.1-1.7-1.51.41.41.4-1.71.4-1.40.6
Bone: cortical thickness0.30.32.90.40.1-0.40.1-0.3-0.9-0.4-0.1-0.1-0.1-0.0-0.2-0.10.11.7
Bone: cortical tissue density0.20.30.5-0.6-0.30.60.60.60.30.40.6-0.7-0.5-0.50.6-0.60.40.6
Condit. Reinf. active minus inactive responses0.70.81.7-0.5-1.31.00.70.91.10.90.8-0.6-0.7-0.90.8-1.00.8-0.8
Condit. Reinf. active-inactive response ratio0.60.61.5-0.4-1.10.90.50.81.20.90.5-0.5-0.5-0.70.7-0.60.5-1.2
Condit. Reinf. active responses0.40.51.1-0.5-1.00.60.50.60.80.70.7-0.4-0.5-0.70.7-1.00.7-0.4
Condit. Reinf. inactive responses0.10.10.6-0.1-0.0-0.3-0.2-0.3-0.3-0.10.20.2-0.00.10.0-0.30.20.8
Incentive salience index mean0.40.51.0-0.5-1.00.70.70.70.80.70.8-0.5-0.6-0.80.7-0.90.70.1
Condit. Reinf. lever presses0.10.11.2-0.3-0.0-0.00.20.1-0.00.10.3-0.1-0.1-0.20.2-0.30.11.1
Condit. Reinf. active minus inactive responses1.62.03.11.61.1-1.4-1.6-1.4-1.1-1.4-1.41.41.41.5-1.31.2-1.4-1.7
Condit. Reinf. active-inactive response ratio0.30.30.8-0.2-0.80.70.20.50.90.50.4-0.5-0.4-0.40.5-0.60.5-0.6
Condit. Reinf. active responses5.47.58.72.92.5-2.9-2.8-2.9-2.8-2.8-2.82.72.82.8-2.72.6-2.8-2.2
Condit. Reinf. inactive responses8.210.113.03.13.2-3.6-3.0-3.4-3.6-3.2-3.23.23.23.2-3.23.2-3.3-1.6
Condit. Reinf. lever presses1.72.33.21.61.5-1.8-1.4-1.6-1.7-1.5-1.51.61.61.4-1.41.5-1.6-0.6
Condit. Reinf. lever reinforcers received4.96.98.12.72.3-2.8-2.6-2.7-2.7-2.6-2.62.62.72.7-2.62.5-2.7-2.2
Conditioned reinforcement - actives1.31.32.61.11.2-1.0-1.6-1.1-0.5-1.1-1.11.31.21.3-0.91.0-1.2-0.7
Conditioned reinforcement - inactives1.21.42.21.51.0-1.2-1.3-1.2-1.0-1.2-1.31.21.21.3-1.21.2-1.2-0.3
Conditioned locomotion1.82.14.11.61.6-1.4-2.0-1.5-0.9-1.6-1.41.61.51.6-1.31.2-1.4-0.6
Patch foraging indifference point 0 sec0.20.31.00.20.4-0.8-0.3-0.6-1.0-0.5-0.50.40.40.4-0.50.6-0.40.7
Patch foraging indifference point AUC1.01.21.80.81.2-1.3-1.1-1.2-1.3-1.2-0.91.21.11.2-1.10.9-1.00.2
Delay disc. indifference point, 0s delay1.11.22.71.60.8-1.2-1.1-1.2-1.1-1.1-1.21.31.11.2-1.20.9-0.8-0.6
Delay disc. indifference point, 16s delay0.30.31.30.80.5-0.4-0.7-0.40.1-0.4-0.60.50.50.5-0.30.7-0.5-1.1
Delay disc. indifference point, 2s delay0.70.82.31.50.8-0.8-0.9-0.9-0.7-0.9-0.90.90.80.9-1.00.8-0.7-0.4
Delay disc. indifference point, 24s delay0.50.53.5-0.4-0.60.50.20.40.80.40.6-0.3-0.4-0.30.4-0.60.6-1.9
Delay disc. indifference point, 4s delay0.70.74.21.10.4-0.6-0.9-0.6-0.2-0.5-0.80.80.80.8-0.60.7-0.6-2.1
Delay disc. indifference point, 8s delay0.90.98.11.10.3-0.7-1.0-0.7-0.1-0.6-0.60.80.50.8-0.50.4-0.3-2.9
Indifference point function ln k1.52.14.7-1.2-1.61.51.31.72.21.91.1-1.4-1.3-1.51.7-1.01.1-0.9
Indifference point function log k1.52.14.7-1.2-1.61.51.31.72.21.91.1-1.4-1.3-1.51.7-1.01.1-0.9
Patch foraging total patch changes 0 sec0.10.20.90.10.2-0.7-0.2-0.6-1.0-0.5-0.40.30.30.3-0.40.5-0.30.8
Patch foraging total patch changes 12 sec0.70.92.40.51.1-1.2-0.8-1.2-1.5-1.2-0.71.00.80.8-0.90.8-0.70.3
Patch foraging total patch changes 18 sec0.50.62.00.20.7-1.1-0.4-0.9-1.4-0.8-0.50.60.60.6-0.70.8-0.70.4
Patch foraging total patch changes 24 sec1.01.23.10.70.9-1.4-0.8-1.3-1.8-1.3-0.81.21.01.0-1.20.9-0.81.1
Patch foraging total patch changes 6 sec0.81.13.50.31.1-1.4-0.7-1.2-1.9-1.3-0.81.00.91.0-1.11.0-0.90.7
Patch foraging time to switch 0 sec0.50.81.4-0.7-0.51.01.00.80.50.60.9-1.0-1.0-1.20.9-1.01.01.1
Patch foraging water rate 0 sec0.20.30.6-0.3-0.80.50.40.50.50.60.4-0.5-0.6-0.50.7-0.60.60.2
Patch foraging water rate 12 sec0.10.10.20.10.2-0.4-0.3-0.4-0.5-0.3-0.30.10.20.4-0.30.3-0.2-0.1
Patch foraging water rate 18 sec1.21.62.31.31.2-1.3-1.4-1.2-1.1-1.1-1.30.91.31.3-1.11.4-1.5-1.1
Patch foraging water rate 24 sec0.50.71.5-1.2-0.80.80.70.91.01.00.9-1.1-0.8-0.71.0-0.70.50.2
Patch foraging water rate 6 sec0.50.71.3-1.0-1.10.80.80.80.80.80.9-0.7-0.7-0.80.8-0.90.7-0.9
Seeking ratio, delayed vs. immediate footshock2.32.73.81.71.8-1.7-1.4-1.7-1.9-1.7-1.81.51.71.5-1.71.7-1.80.1
Distance traveled before self-admin4.44.76.42.22.1-2.4-2.0-2.3-2.5-2.3-2.22.22.12.3-2.42.2-2.1-0.8
Distance traveled after self-admin3.13.54.12.02.0-2.0-1.8-2.0-2.0-1.9-1.91.81.91.8-1.71.9-1.9-1.1
Extensor digitorum longus weight0.72.74.42.11.3-1.9-1.7-1.7-1.6-1.5-1.71.71.71.7-1.71.6-1.7-0.6
Bone: elastic displacement0.50.61.1-0.8-0.70.70.80.80.70.90.8-1.1-0.9-0.81.0-0.60.7-0.1
Bone: elastic work0.00.00.2-0.10.1-0.20.2-0.1-0.30.1-0.1-0.20.0-0.10.10.3-0.2-0.5
Bone: endosteal estimation2.14.65.72.32.0-2.1-2.4-2.1-1.3-1.9-2.32.42.22.2-1.92.2-2.1-2.3
Bone: endosteal perimeter1.83.85.12.01.9-2.0-2.2-1.9-1.3-1.7-2.12.32.12.0-1.82.1-2.0-1.7
Epididymis fat weight0.51.12.31.51.1-0.8-1.3-1.0-0.4-1.0-1.21.21.11.1-0.91.0-1.0-0.8
Delta time in closed arm before/after self-admin0.30.32.0-0.1-0.20.4-0.20.30.80.20.3-0.2-0.3-0.20.5-0.30.3-1.4
Delta time in open arm before/after self-admin0.20.22.4-0.2-0.40.10.50.2-0.20.20.2-0.2-0.2-0.1-0.1-0.20.21.5
Diff in mean of infusions in LGA sessions0.91.01.7-1.1-0.90.90.81.01.01.00.9-1.2-1.1-1.11.3-1.11.10.6
Delay discount exponential model param0.70.76.2-1.0-0.40.50.90.5-0.00.40.5-0.7-0.5-0.70.4-0.50.42.5
Extinction: sum of active levers before priming1.21.22.31.50.8-1.1-0.4-1.0-1.4-0.9-1.21.01.01.1-1.51.1-1.11.0
Active lever presses in extinction session 60.60.61.1-0.5-1.00.90.60.81.00.80.7-0.8-0.8-0.70.9-0.70.7-0.5
Bone: final force1.93.14.41.82.1-2.0-1.9-1.9-2.0-1.9-1.81.71.71.6-1.61.7-1.70.2
Bone: final moment2.64.15.42.12.3-2.2-2.2-2.2-2.2-2.1-2.12.02.01.9-1.92.1-2.0-0.1
Food consumed during 24 hour testing period0.10.10.2-0.4-0.50.20.30.30.20.30.4-0.3-0.3-0.20.3-0.40.3-0.2
Glucose0.20.30.6-0.00.7-0.2-0.3-0.4-0.7-0.7-0.30.50.40.4-0.70.3-0.40.8
Heart weight0.30.41.20.80.5-0.5-0.3-0.6-1.1-0.8-0.60.60.50.5-0.90.5-0.50.6
Delay discount hyperbolic model param0.80.85.5-1.1-0.50.61.00.70.10.60.7-0.8-0.7-0.80.6-0.60.52.3
Intermittent access intake day 1-15 change3.83.76.11.82.0-1.9-2.3-1.8-1.1-1.7-2.02.02.02.0-1.52.0-2.0-2.5
Intermittent access intake escalation2.52.47.41.41.5-1.4-1.8-1.4-0.6-1.2-1.51.61.51.6-1.11.6-1.6-2.7
Intermittent access intake escalation 20.90.97.40.60.6-0.6-1.1-0.60.3-0.3-0.70.70.70.7-0.10.7-0.7-2.7
Intermitt. access day 1 inactive lever presses4.54.85.72.32.1-2.3-2.0-2.2-2.1-2.1-2.32.42.32.2-2.32.4-2.3-1.5
Intermitt. access day 15 inactive lever presses1.31.52.11.11.3-1.3-1.3-1.2-0.9-1.1-1.31.31.31.4-1.11.4-1.3-0.8
Intermitt. access escalation Index1.61.42.71.01.1-1.3-0.9-1.3-1.6-1.3-1.11.01.11.2-1.41.0-1.01.4
Intermittent access day 1 total infusions0.70.81.71.11.3-0.9-1.3-1.0-0.7-1.1-0.90.70.80.8-0.50.8-0.90.3
Intermittent access day 15 total infusions3.03.45.52.02.2-1.8-2.4-1.9-1.2-1.8-1.91.81.81.9-1.31.9-2.0-1.3
Intermittent access terminal intake (last 3 days)1.61.83.61.51.7-1.4-1.9-1.4-0.8-1.3-1.41.21.31.4-0.71.3-1.4-0.8
Intermittent access total infusions1.21.33.21.31.7-1.1-1.8-1.1-0.5-1.2-1.21.01.11.1-0.51.1-1.2-0.1
Intermittent access day 1 locomotion0.20.31.20.80.6-0.3-0.8-0.4-0.1-0.5-0.40.30.20.30.00.1-0.31.1
Intermittent access day 15 total locomotion0.50.63.1-0.1-0.20.5-0.50.41.40.50.4-0.3-0.4-0.51.2-0.60.5-1.8
Intermittent access total locomotion0.30.31.10.90.9-0.5-1.0-0.6-0.1-0.7-0.60.50.40.5-0.00.3-0.4-0.1
Intermittent access standard deviation6.46.88.83.02.6-2.5-3.0-2.5-1.8-2.4-2.82.82.72.7-2.32.6-2.6-2.6
Left kidney weight5.515.520.14.34.5-3.9-3.9-4.2-4.2-4.5-4.04.13.93.9-4.23.7-3.7-0.2
Right kidney weight1.43.96.12.52.3-1.9-1.7-2.1-2.4-2.3-2.01.91.81.7-2.21.7-1.71.1
Cocaine induced anxiety0.20.33.20.0-0.50.10.50.1-0.5-0.00.2-0.1-0.2-0.0-0.5-0.20.21.8
Post-drug Anxiety0.60.72.1-0.7-1.10.71.20.80.10.80.6-0.8-0.7-0.70.3-0.70.71.4
Baseline Anxiety0.20.22.70.1-0.00.0-0.00.10.30.2-0.1-0.10.00.00.20.1-0.1-1.6
Tail length0.41.42.91.71.0-1.2-1.3-1.2-1.1-1.2-1.31.01.11.1-1.11.1-1.0-0.7
Length with tail1.45.38.32.92.2-2.3-2.3-2.5-2.6-2.7-2.32.32.22.2-2.52.1-2.00.1
Length without tail2.35.17.42.22.4-2.2-2.0-2.4-2.7-2.6-2.12.42.22.2-2.72.1-2.10.5
Times rat made contact with spout1.92.22.9-1.6-1.31.41.51.41.01.31.6-1.5-1.6-1.51.5-1.71.61.7
Lifetime Intake0.60.72.30.91.3-0.8-1.5-0.9-0.3-0.9-0.80.70.80.9-0.20.7-0.80.1
Liver weight, left3.86.18.42.92.5-2.4-2.6-2.5-2.2-2.6-2.62.52.42.5-2.42.3-2.3-2.1
Liver weight, right2.54.16.02.12.2-2.1-1.8-2.2-2.5-2.3-2.02.12.01.9-2.31.9-1.90.1
Locomotor activity7.912.515.23.73.6-3.7-3.4-3.8-3.8-3.8-3.53.73.63.6-3.93.3-3.5-1.2
Locomotor testing distance3.86.37.42.62.4-2.7-2.5-2.7-2.5-2.6-2.52.62.52.7-2.72.4-2.5-1.6
Locomotor testing rearing4.06.27.32.32.6-2.7-2.5-2.7-2.6-2.6-2.42.52.52.7-2.52.4-2.5-1.8
Locomotion in novel chamber3.03.75.12.12.0-2.0-1.7-1.9-1.9-1.8-2.11.82.12.0-1.92.2-2.3-0.3
Locomotion in novel chamber post-restriction0.50.61.71.01.1-0.7-1.3-0.8-0.4-0.9-0.90.60.60.7-0.30.6-0.7-0.5
Fecal boli incidents, locomotor time 12.93.14.11.71.8-1.8-1.8-1.9-2.0-1.9-1.71.81.71.9-2.01.6-1.7-0.8
Change in fecal boli incidents, locomotor task3.43.25.1-1.5-2.21.91.51.82.31.91.8-1.4-1.7-1.71.8-1.92.0-0.8
Time >=10cm from walls, locomotor time 10.40.40.90.50.9-0.5-0.8-0.6-0.6-0.7-0.50.30.30.5-0.40.5-0.50.9
Bouts of movement, locomotor time 10.50.61.3-0.6-0.50.80.20.61.10.60.6-0.5-0.7-0.60.9-0.90.8-1.1
Total resting periods, locomotor time 10.40.41.0-0.5-0.30.80.20.61.00.50.6-0.4-0.7-0.60.8-0.90.8-0.2
Rest time, locomotor task time 11.71.93.1-1.3-1.11.71.01.41.81.31.3-1.3-1.4-1.11.5-1.31.41.4
Distance moved, locomotor task time 11.71.83.21.41.3-1.5-1.0-1.4-1.8-1.4-1.41.21.31.1-1.51.5-1.5-0.3
Vertical activity count, locomotor time 12.52.65.01.61.5-1.9-1.1-1.7-2.2-1.7-1.61.51.61.4-1.91.7-1.7-0.2
Time >=10cm from walls, locomotor time 20.20.21.60.20.2-0.1-0.2-0.2-0.6-0.4-0.00.1-0.00.3-0.4-0.0-0.01.3
Bouts of movement, locomotor time 21.51.62.3-1.2-1.01.51.21.41.51.31.1-1.4-1.2-1.31.4-1.21.30.5
Total resting periods, locomotor time 22.32.53.5-1.5-1.31.91.41.71.81.61.5-1.7-1.6-1.61.8-1.61.70.6
Rest time, locomotor task time 22.93.34.5-1.7-1.71.91.51.81.91.61.9-1.9-2.0-1.82.0-2.02.11.4
Distance moved, locomotor task time 22.02.33.01.61.6-1.6-1.4-1.5-1.7-1.5-1.61.51.51.4-1.61.6-1.70.3
Vertical activity count, locomotor time 23.33.66.11.91.9-2.1-1.4-1.9-2.5-1.9-1.91.81.81.7-2.22.0-2.00.9
Light reinforcement 10.71.33.21.11.1-1.2-0.9-1.3-1.8-1.4-1.10.90.91.0-1.31.0-1.00.9
Light reinforcement 20.40.61.00.51.0-0.8-0.7-0.8-1.0-0.9-0.70.70.80.7-0.70.8-0.80.0
Bone: marrow area2.14.75.92.32.1-2.1-2.4-2.1-1.3-1.9-2.32.42.32.2-1.92.2-2.2-2.4
Bone: maximum diameter3.56.57.92.72.5-2.8-2.5-2.7-2.6-2.6-2.62.82.62.7-2.72.6-2.4-0.7
Bone: maximum force2.95.06.32.42.5-2.5-2.4-2.4-2.3-2.3-2.42.32.32.1-2.12.3-2.2-0.7
Bone: maximum moment3.76.37.52.62.7-2.7-2.7-2.6-2.5-2.5-2.72.62.62.4-2.42.7-2.6-1.1
Mean time between licks in bursts0.30.40.60.60.6-0.6-0.6-0.5-0.4-0.5-0.70.80.80.6-0.70.8-0.7-0.7
Mean num. licks in bursts0.40.50.7-0.6-0.90.50.50.60.80.80.7-0.7-0.7-0.60.8-0.80.8-0.1
Cd content in liver2.02.13.31.61.8-1.5-1.7-1.6-1.4-1.6-1.61.41.41.3-1.31.5-1.5-0.3
Co content in liver0.10.10.3-0.1-0.10.10.20.20.20.30.1-0.6-0.3-0.40.6-0.20.20.2
Cu content in liver1.62.03.0-1.7-0.91.31.61.30.91.31.4-1.6-1.4-1.61.4-1.21.31.6
Fe content in liver0.50.61.50.50.8-0.7-0.6-0.8-1.1-0.9-0.60.60.50.5-0.70.7-0.51.2
K content in liver0.10.10.2-0.4-0.10.30.20.30.30.20.2-0.4-0.2-0.30.3-0.20.1-0.3
Mg content in liver0.00.00.2-0.20.1-0.00.1-0.1-0.1-0.10.0-0.10.10.1-0.10.1-0.2-0.4
Mn content in liver2.02.22.91.61.4-1.5-1.7-1.6-1.6-1.7-1.51.51.51.6-1.71.4-1.4-0.4
Na content in liver1.92.02.71.61.4-1.6-1.4-1.6-1.6-1.6-1.51.21.31.3-1.41.3-1.3-0.4
Rb content in liver0.00.00.2-0.2-0.30.10.10.0-0.3-0.10.2-0.3-0.10.0-0.1-0.2-0.00.5
Se content in liver0.70.81.4-0.6-0.81.20.70.90.80.60.7-0.9-1.0-1.10.8-1.01.01.2
Sr content in liver2.01.82.61.51.3-1.4-1.6-1.3-0.8-1.1-1.51.41.41.4-1.01.3-1.3-1.5
Zn content in liver0.50.51.20.21.1-0.8-0.5-0.8-1.1-0.8-0.60.60.70.6-0.60.8-0.80.7
Bone: minimum diameter1.12.02.91.71.5-1.4-1.5-1.4-1.2-1.3-1.61.51.41.3-1.31.5-1.3-0.8
Time in familiar zone, hab. session 10.30.22.1-0.50.10.20.50.2-0.20.20.4-0.4-0.4-0.30.2-0.20.31.5
Time in novel zone, hab. session 10.10.10.90.1-0.20.1-0.00.10.30.1-0.10.00.0-0.00.00.10.1-0.9
Total zone transitions, hab. session 10.10.10.20.30.5-0.5-0.3-0.4-0.4-0.3-0.40.30.30.3-0.20.5-0.30.4
Total locomotion distance, hab. session 10.10.10.20.30.4-0.3-0.3-0.2-0.3-0.2-0.40.10.20.2-0.00.4-0.30.4
Locomotion velocity, hab. session 10.00.00.30.00.2-0.1-0.0-0.0-0.10.0-0.2-0.1-0.0-0.00.10.2-0.10.5
Time in familiar zone, hab. session 20.80.94.4-1.0-0.40.51.30.7-0.00.70.9-0.9-0.8-0.90.5-0.70.82.1
Time in novel zone, hab. session 20.10.11.2-0.1-0.40.30.10.30.40.3-0.1-0.2-0.1-0.20.20.20.0-1.1
Total zone transitions, hab. session 20.60.81.30.81.0-1.0-1.0-0.8-0.5-0.6-1.00.80.90.8-0.51.1-0.9-1.1
Total locomotion distance, hab. session 20.00.00.2-0.00.4-0.3-0.1-0.2-0.2-0.0-0.20.10.10.10.10.5-0.2-0.1
Locomotion velocity, hab. session 20.30.40.90.40.9-0.8-0.6-0.6-0.5-0.5-0.70.50.60.5-0.30.9-0.7-0.4
Novel to familiar place preference ratio0.10.10.90.2-0.20.4-0.20.20.60.1-0.0-0.0-0.1-0.10.3-0.20.1-0.9
Novelty place preference0.10.10.60.30.10.2-0.30.00.4-0.1-0.20.10.10.00.1-0.0-0.1-0.8
Time in novel zone, NPP test0.00.00.40.2-0.00.2-0.10.10.3-0.0-0.10.0-0.1-0.10.1-0.00.1-0.6
Total zone transitions, NPP test0.20.30.40.50.5-0.6-0.6-0.5-0.4-0.4-0.50.50.40.5-0.30.5-0.3-0.7
Total locomotion distance, NPP test0.00.00.1-0.10.0-0.10.10.00.00.20.0-0.1-0.2-0.20.30.00.20.2
Locomotion velocity, NPP test0.00.00.10.10.0-0.2-0.2-0.10.00.0-0.00.10.00.00.1-0.1-0.00.1
Intraocular pressure0.30.51.00.80.9-0.8-0.8-0.7-0.7-0.7-0.70.50.50.4-0.30.7-0.61.0
Delta distance traveled before/after self-admin0.20.20.5-0.5-0.10.40.40.40.60.50.4-0.4-0.3-0.60.7-0.30.2-0.2
Delta ambulatory time before/after self-admin0.50.61.3-0.8-0.40.80.50.71.00.80.7-0.8-0.7-0.91.2-0.70.6-0.6
Parametrial fat weight0.30.51.4-0.0-0.60.90.20.81.20.60.4-0.7-0.8-0.60.9-0.90.9-0.2
Pavlov. Cond. lever latency0.00.00.20.20.00.00.1-0.1-0.4-0.3-0.1-0.1-0.10.0-0.30.10.1-0.0
Pavlov. Cond. magazine entry latency0.00.00.20.10.4-0.2-0.2-0.10.0-0.0-0.20.00.2-0.00.20.3-0.3-0.1
Pavlov. Cond. change in total contacts0.10.10.2-0.3-0.20.10.10.20.40.30.2-0.1-0.1-0.30.4-0.20.0-0.2
Pavlov. Cond. index score0.10.10.30.20.5-0.4-0.4-0.3-0.1-0.2-0.40.40.40.3-0.10.4-0.5-0.3
Pavlov. Cond. latency score0.00.00.1-0.00.3-0.2-0.2-0.10.10.0-0.10.10.20.10.10.2-0.3-0.1
Pavlov. Cond. lever contacts0.00.10.2-0.4-0.30.00.10.20.40.40.2-0.00.0-0.10.3-0.1-0.1-0.1
Pavlov. Cond. magazine entry number0.81.02.1-0.9-1.41.11.01.01.01.01.1-1.0-1.1-0.90.7-1.21.20.1
Pavlov. Cond. intertrial magazine entries7.28.713.2-3.1-3.63.03.02.92.52.83.3-2.9-3.0-2.82.6-3.33.21.5
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.00.3-0.2-0.2-0.10.10.0-0.20.20.30.10.00.3-0.4-0.3
Pavlov. Cond. response bias0.20.20.50.30.7-0.6-0.4-0.5-0.4-0.4-0.50.40.50.3-0.20.5-0.60.2
Pavlov. Cond. lever latency0.50.71.2-0.9-1.01.10.81.01.00.80.9-0.8-0.8-0.70.6-0.80.90.5
Pavlov. Cond. magazine entry latency0.00.00.30.2-0.3-0.1-0.2-0.00.10.00.00.20.0-0.10.0-0.20.1-0.5
Pavlov. Cond. change in total contacts1.72.33.01.71.4-1.7-1.5-1.6-1.5-1.5-1.51.71.61.4-1.51.3-1.5-1.0
Pavlov. Cond. index score0.20.20.50.60.3-0.7-0.5-0.6-0.7-0.5-0.40.60.50.3-0.40.3-0.4-0.2
Pavlov. Cond. latency score0.10.10.20.40.1-0.5-0.3-0.4-0.4-0.3-0.20.40.30.1-0.10.0-0.2-0.1
Pavlov. Cond. lever contacts1.01.42.01.31.2-1.4-1.1-1.3-1.4-1.2-1.21.11.11.0-1.01.1-1.1-0.5
Pavlov. Cond. magazine entry number0.40.50.9-0.9-0.50.80.70.80.80.80.6-0.9-0.7-0.50.6-0.30.50.4
Pavlov. Cond. intertrial magazine entries1.01.41.8-1.2-1.31.21.31.21.21.31.2-1.3-1.2-1.11.1-1.11.10.5
Pavlov. Cond. lever-magazine prob. diff.0.20.20.50.60.3-0.7-0.5-0.6-0.6-0.5-0.50.60.50.4-0.30.3-0.4-0.2
Pavlov. Cond. response bias0.91.21.81.30.9-1.3-1.1-1.2-1.3-1.1-1.11.21.11.0-1.01.0-1.1-0.9
Time in closed arm before self-admin3.23.65.81.61.9-2.0-1.6-2.0-2.4-2.0-1.91.91.91.8-2.12.0-1.91.0
Time in closed arm after self-admin0.20.20.70.10.6-0.3-0.7-0.30.1-0.3-0.30.40.30.3-0.00.3-0.3-0.9
Time in open arm before self-admin1.31.54.2-0.7-1.21.10.81.01.51.11.1-1.0-1.1-1.11.4-1.21.1-2.0
Time in open arm after self-admin1.51.72.5-1.0-1.61.41.11.41.61.31.3-1.3-1.3-1.21.3-1.51.30.4
Bone: periosteal estimation3.67.59.43.12.7-2.9-2.9-2.8-2.4-2.7-2.93.02.82.8-2.72.8-2.6-1.6
Bone: periosteal perimeter3.55.87.12.62.5-2.7-2.5-2.5-2.4-2.4-2.52.62.52.4-2.42.5-2.4-0.8
Bone: post-yield work1.01.37.31.20.8-0.8-1.3-0.8-0.1-0.6-1.21.11.00.8-0.61.1-1.0-2.7
Progressive ratio test 1 active lever presses0.20.21.10.50.8-0.3-1.1-0.40.3-0.4-0.40.20.30.40.30.2-0.3-0.1
Progressive ratio test 1 breakpoint0.30.31.50.60.9-0.4-1.2-0.50.2-0.5-0.40.30.30.50.20.2-0.30.1
Progressive ratio test 1 inactive lever presses0.70.82.01.11.1-0.8-1.4-0.9-0.3-0.9-1.00.80.90.9-0.50.8-0.90.1
Progressive ratio test 2 active lever presses0.40.41.00.61.0-0.7-1.0-0.7-0.4-0.8-0.60.60.60.6-0.20.6-0.60.2
Progressive ratio test 2 breakpoint0.50.51.30.61.1-0.7-1.1-0.8-0.5-0.8-0.60.60.60.7-0.30.6-0.60.6
Progressive ratio test 2 inactive lever presses0.70.92.51.21.2-0.8-1.6-0.9-0.1-0.9-1.10.90.90.9-0.30.8-0.9-0.2
Incentive Sensitization - Responses0.40.40.90.20.9-0.8-0.6-0.7-0.8-0.7-0.50.60.60.5-0.50.8-0.6-0.4
Incentive Sensitization - Breakpoint0.50.50.90.31.0-0.8-0.6-0.8-0.8-0.8-0.60.70.70.6-0.60.8-0.7-0.4
Sum of active levers in priming session hrs 5-60.40.40.80.90.4-0.6-0.2-0.5-0.9-0.6-0.70.50.60.6-0.90.6-0.70.7
Progressive ratio0.10.10.40.3-0.20.2-0.10.20.70.30.00.0-0.2-0.10.3-0.30.3-0.5
Food seeking constrained by brief footshock0.10.10.4-0.5-0.60.30.60.30.10.30.5-0.1-0.3-0.30.1-0.30.50.2
Seeking ratio, punishment vs. effort0.00.10.3-0.3-0.1-0.20.1-0.2-0.6-0.20.10.20.10.1-0.40.2-0.10.2
Retroperitoneal fat weight0.00.00.50.7-0.00.2-0.20.00.2-0.1-0.20.10.00.1-0.1-0.10.1-0.0
Reaction time number correct0.50.71.9-0.4-1.01.00.61.01.41.10.5-1.1-0.7-0.71.0-0.50.4-0.4
Reaction time mean minus median0.30.41.20.51.1-0.5-0.6-0.6-0.6-0.7-0.70.40.60.4-0.40.9-0.8-0.1
Reaction time mean minus median AUC0.20.21.20.11.1-0.3-0.2-0.4-0.6-0.5-0.50.20.40.1-0.20.7-0.60.0
Reaction time num false alarms0.50.71.10.80.7-1.0-0.9-0.8-0.7-0.7-0.81.10.91.0-0.90.8-0.90.5
Reaction time num false alarms AUC0.60.81.31.20.6-0.9-1.1-0.8-0.4-0.6-1.11.11.01.1-0.90.9-1.0-0.3
Reaction time trials correct on left0.50.71.9-0.4-1.01.00.61.01.41.10.5-1.1-0.7-0.71.0-0.50.4-0.4
Reaction time trials on left0.50.82.0-0.4-1.11.00.61.01.41.10.5-1.1-0.7-0.81.0-0.50.4-0.5
Reaction time mean0.10.10.5-0.00.2-0.30.2-0.2-0.7-0.2-0.20.10.2-0.1-0.30.4-0.4-0.0
Reaction time mean AUC0.00.10.3-0.4-0.10.10.50.2-0.20.20.2-0.2-0.1-0.40.10.10.0-0.1
Median of all reaction times0.00.10.3-0.3-0.3-0.10.60.1-0.50.10.2-0.1-0.0-0.3-0.10.1-0.10.0
Reaction time omissions0.20.33.00.40.1-0.0-0.70.00.80.2-0.4-0.00.10.10.50.2-0.3-1.7
Reaction time false alarm rate0.91.32.31.11.0-1.3-1.2-1.2-1.0-1.0-1.21.51.21.3-1.31.0-1.1-0.0
Reaction time premature initiation rate2.12.84.1-2.0-2.01.51.91.61.31.71.9-1.7-1.7-1.71.5-1.81.70.8
Reaction time premature initiations2.63.65.2-1.8-2.31.81.92.02.02.11.9-2.1-2.0-1.92.0-1.91.80.3
Std. dev. reaction times0.10.10.30.20.5-0.2-0.2-0.2-0.2-0.2-0.30.00.2-0.00.10.4-0.3-0.4
Reaction time trials completed0.50.82.0-0.4-1.11.00.61.01.41.10.5-1.1-0.7-0.81.0-0.50.4-0.5
Reaction time trials AUC0.30.51.3-0.2-0.90.80.40.81.20.90.4-1.0-0.6-0.60.8-0.30.3-0.2
Run reversals in cocaine runway, females0.10.10.20.20.2-0.4-0.1-0.3-0.3-0.2-0.30.40.30.2-0.20.2-0.2-0.0
Run reversals in cocaine runway, males0.50.50.90.90.4-0.6-0.5-0.7-0.9-0.9-0.60.70.60.6-0.80.5-0.5-0.9
Latency to leave start box in cocaine runway0.60.71.3-0.9-0.80.81.10.80.20.60.9-0.9-0.9-0.90.6-1.00.90.0
Latency to leave start box in cocaine runway, F0.30.31.10.30.3-0.40.1-0.4-1.1-0.5-0.40.40.40.3-0.80.3-0.3-0.9
Latency to leave start box in cocaine runway, M6.66.47.3-2.6-2.42.62.32.52.42.42.7-2.7-2.7-2.52.7-2.72.71.8
Std. dev. time between licks in bursts0.50.60.90.70.9-0.8-0.8-0.7-0.6-0.6-0.80.80.80.6-0.61.0-0.8-0.5
Total sessions with >9 infusions2.02.23.91.61.7-1.5-2.0-1.5-1.0-1.5-1.51.61.51.6-1.31.4-1.4-0.8
Short access day 1 total inactive lever presses0.30.31.11.00.7-0.6-1.0-0.6-0.1-0.5-0.70.40.40.5-0.10.4-0.40.5
Short access day 10 total inactive lever presses3.03.34.61.81.8-2.0-1.4-1.9-2.0-1.8-2.01.81.91.8-1.92.2-2.0-0.8
Short access day 1 total infusions1.31.43.11.21.5-1.2-1.8-1.3-1.0-1.4-1.11.21.01.3-0.80.9-0.90.7
Short access day 10 total infusions0.30.41.30.80.9-0.5-1.1-0.6-0.2-0.7-0.60.50.40.6-0.10.4-0.50.6
Short access total infusions0.30.41.60.60.9-0.4-1.2-0.5-0.1-0.6-0.50.40.40.60.00.3-0.40.9
Short access day 1 locomotion0.60.73.30.91.0-0.5-1.2-0.6-0.2-0.7-0.60.60.50.8-0.40.5-0.41.8
Short access day 10 total locomotion3.84.26.22.32.2-2.0-2.5-2.2-1.9-2.3-2.02.42.12.2-2.01.7-1.8-0.5
Short access total locomotion2.12.25.41.81.9-1.3-2.3-1.5-0.7-1.6-1.51.61.41.6-1.01.2-1.20.6
One hour access (0.3 mA shock)2.83.34.21.81.9-1.9-2.0-1.8-1.4-1.7-1.91.71.91.8-1.42.0-2.0-1.6
Compulsive drug intake2.22.33.61.51.0-1.5-0.9-1.5-1.9-1.4-1.51.51.61.4-1.91.6-1.6-1.5
One hour access (shock baseline)0.70.82.01.01.2-1.0-1.4-1.0-0.5-0.9-0.90.90.80.9-0.40.8-0.8-0.6
Social response proportion0.20.20.8-0.2-0.90.40.70.4-0.10.20.4-0.2-0.3-0.3-0.2-0.50.40.5
Social responses3.03.85.12.31.8-2.0-2.0-2.0-1.9-2.1-2.02.11.92.2-2.11.7-1.8-0.9
Social time0.20.31.01.00.3-0.4-0.6-0.4-0.3-0.5-0.80.60.50.5-0.50.4-0.4-0.0
Soleus weight4.011.614.53.83.5-3.6-3.7-3.5-3.2-3.4-3.63.43.43.4-3.33.5-3.4-2.0
Bone: stiffness4.77.39.03.03.0-2.9-2.9-2.9-2.7-2.9-2.82.92.72.7-2.72.6-2.6-0.8
Tibialis anterior weight2.37.99.63.12.7-3.0-3.1-3.0-2.7-2.9-3.02.82.92.9-2.82.8-2.9-1.2
Time to tail flick, vehicle, before self-admin0.30.42.60.70.20.0-0.6-0.20.3-0.3-0.60.50.50.6-0.40.5-0.4-1.6
Time to tail flick, vehicle, after self-admin0.20.20.6-0.1-0.30.6-0.10.40.80.30.2-0.1-0.3-0.10.4-0.40.40.8
Time to tail flick, test, before self-admin0.60.61.50.60.8-0.8-0.5-0.8-1.2-1.0-0.60.80.80.7-1.00.7-0.80.3
Time to tail flick, test, after self-admin0.80.81.71.00.7-0.8-0.3-0.8-1.2-0.9-0.91.00.90.8-1.31.0-0.9-0.2
Delta time to tail flick, vehicle, before/after SA0.10.12.00.00.00.1-0.2-0.00.1-0.10.2-0.0-0.1-0.00.1-0.10.11.4
Delta time to tail flick, test, before/after SA0.00.00.20.1-0.0-0.10.1-0.1-0.1-0.0-0.20.20.20.2-0.40.3-0.2-0.4
Tibia length1.23.44.82.21.9-2.0-2.1-1.9-1.5-1.8-1.92.21.91.7-1.81.7-1.6-0.8
Ambulatory time before self-admin2.93.05.21.81.6-2.0-1.4-1.9-2.3-1.8-1.81.71.71.8-2.01.7-1.7-0.4
Ambulatory time after self-admin2.22.43.11.81.7-1.7-1.5-1.6-1.6-1.5-1.61.51.51.5-1.31.6-1.6-0.9
Bone: tissue strength2.82.88.31.41.2-1.5-1.6-1.5-1.2-1.4-1.61.71.61.6-1.61.7-1.6-2.9
Total heroin consumption0.30.41.10.60.6-0.6-0.3-0.6-1.1-0.7-0.50.30.40.5-0.70.5-0.50.8
Bone: trabecular number0.60.91.51.01.2-1.0-1.0-1.0-1.0-1.0-1.10.80.90.9-0.91.1-1.1-0.1
Bone: trabecular spacing1.11.42.2-1.0-1.51.31.01.21.51.21.3-1.0-1.2-1.01.1-1.41.40.3
Bone: trabecular thickness1.01.12.01.01.3-1.1-1.0-1.1-1.4-1.1-1.11.01.00.9-1.01.1-1.00.6
Bone: trabecular tissue density0.30.40.60.80.6-0.5-0.7-0.6-0.4-0.7-0.70.70.60.7-0.60.6-0.6-0.6
Water consumed over 24 hours1.31.62.4-1.6-1.41.21.51.30.71.31.4-1.3-1.3-1.21.2-1.31.20.8
Number of responses in last shaping day0.30.30.90.60.8-0.1-0.9-0.10.5-0.1-0.60.20.30.40.40.5-0.40.7