Hub : Genes

Hnrnpl

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb mRNA stability Hnrnpl 0.34 0.17 1.5e-06 0.24 0.22 0.23 0.24 2.5e-06 7.4e-06 3.9e-06 2.6e-06
2 Liver mRNA stability Hnrnpl 0.67 0.17 0.0e+00 0.4 0.41 0.41 0.41 5.9e-48 2.5e-48 7.4e-49 1.1e-48
3 NAcc mRNA stability Hnrnpl 0.04 0.03 1.7e-05 0.04 0.04 0.04 0.04 1.6e-05 6.2e-06 1.7e-05 1.1e-05
4 PL mRNA stability Hnrnpl 0.05 0.04 4.8e-06 0.06 0.04 0.03 0.04 1.2e-06 4.5e-05 1.9e-04 9.8e-06
5 OFC mRNA stability Hnrnpl 0.23 0.14 4.2e-04 0.13 0.09 0.05 0.11 6.3e-04 4.2e-03 2.4e-02 1.4e-03
6 Brain mRNA stability Hnrnpl 0.17 0.1 7.2e-16 0.17 0.16 0.17 0.17 5.0e-16 7.4e-15 7.7e-16 6.6e-16
7 IL mRNA stability Hnrnpl 0.36 0.18 1.1e-06 0.26 0.24 0.27 0.26 4.9e-07 2.0e-06 3.1e-07 7.0e-07
8 RMTg mRNA stability Hnrnpl 0.34 0.17 1.4e-07 0.27 0.02 0.25 0.06 5.7e-08 8.9e-02 2.6e-07 9.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.10.10.30.20.40.30.20.20.60.60.2
Area under the delay curve0.00.00.2-0.3-0.1-0.40.10.10.20.0-0.2
BMI with tail0.10.30.80.40.5-0.90.40.40.40.50.5
BMI without tail0.20.50.6-0.8-0.70.1-0.8-0.8-0.6-0.6-0.8
Body weight2.510.713.5-3.7-3.43.5-2.9-2.9-2.9-3.1-3.6
Weight adjusted by age0.10.10.20.50.4-0.50.20.20.20.30.4
Bone surface0.30.61.8-0.6-0.61.3-0.8-0.8-0.3-0.4-0.8
Bone volume0.30.61.7-0.7-0.61.3-0.8-0.8-0.4-0.4-0.8
Breakpoint value in progressive ratio session1.01.11.5-1.1-1.1-0.4-1.1-1.1-1.1-1.2-0.9
Number of licking bursts1.82.13.41.81.6-0.31.31.31.41.51.7
Context. condit. distance diff. score0.10.10.10.30.3-0.30.30.30.30.30.3
Locomotion velocity, session 12.72.93.51.71.7-1.91.71.71.61.61.8
Locomotion distance, session 10.70.91.1-1.0-1.00.9-0.8-0.8-1.0-1.0-1.0
Locomotion velocity, session 20.30.40.50.40.6-0.60.70.70.70.60.5
Locomotion distance, session 20.50.71.90.60.7-1.40.90.90.80.70.7
Locomotion velocity, session 30.30.31.20.50.41.10.40.40.30.40.5
Locomotion distance, session 36.47.07.8-2.6-2.72.8-2.6-2.6-2.6-2.6-2.7
Stereotopy head waving bouts, day 30.50.61.11.00.7-1.00.50.50.50.60.9
Stereotopy head waving duration, day 32.63.13.82.01.8-1.81.71.71.71.71.8
Locomotion velocity, session 70.10.10.5-0.1-0.00.70.10.10.20.1-0.1
Locomotion distance, session 70.10.20.7-0.4-0.30.9-0.4-0.4-0.2-0.2-0.3
Stereotopy head waving bouts, day 70.00.00.20.30.2-0.40.10.10.20.20.1
Stereotopy head waving duration, day 71.01.22.21.11.0-1.50.90.91.01.01.0
Locomotion velocity, session 82.83.44.01.92.0-1.21.81.82.01.92.0
Locomotion distance, session 80.40.61.70.60.7-1.30.70.70.70.60.7
Degree of sensitization distance3.63.64.11.82.0-1.61.91.92.02.02.0
Degree of sensitization stereotypy0.00.00.30.1-0.0-0.6-0.1-0.1-0.0-0.1-0.1
Conditioned locomotion0.70.82.4-0.4-0.71.5-0.9-0.9-0.9-0.7-0.7
Cocaine response after cond. corrected0.60.71.3-0.7-0.81.1-0.8-0.8-0.8-0.7-0.8
Cocaine response after cond. not corrected1.11.21.7-1.0-1.01.3-1.2-1.2-1.0-1.0-1.0
Cocaine response before conditioning1.92.23.1-1.5-1.51.0-1.8-1.8-1.5-1.5-1.4
Saline control response0.50.60.9-0.7-0.8-0.5-0.9-0.9-0.9-0.8-0.8
Bone: connectivity density0.50.81.20.80.9-0.30.90.91.11.10.8
Bone: cortical apparent density2.43.25.01.71.7-2.21.71.71.71.71.7
Bone: cortical area2.03.03.5-1.7-1.81.3-1.9-1.9-1.7-1.8-1.8
Bone: cortical porosity0.50.50.60.70.8-0.70.70.70.80.70.7
Bone: cortical porosity0.60.60.70.80.8-0.70.80.80.80.80.8
Bone: cortical thickness0.81.41.8-1.1-1.20.8-1.3-1.3-1.1-1.2-1.2
Bone: cortical thickness0.00.00.10.10.20.20.20.20.20.20.2
Bone: cortical tissue density2.83.75.41.81.8-2.31.91.91.81.81.9
Condit. Reinf. active minus inactive responses0.20.20.50.60.6-0.10.40.40.40.50.7
Condit. Reinf. active-inactive response ratio0.20.20.60.80.5-0.30.20.20.40.30.7
Condit. Reinf. active responses0.81.01.31.01.1-0.61.11.11.11.11.1
Condit. Reinf. inactive responses0.60.71.00.50.8-0.61.01.00.91.00.7
Incentive salience index mean0.10.10.50.00.10.70.00.00.10.10.2
Condit. Reinf. lever presses0.20.30.8-0.7-0.50.9-0.3-0.3-0.3-0.4-0.5
Condit. Reinf. active minus inactive responses4.45.46.4-2.2-2.41.7-2.5-2.5-2.5-2.5-2.2
Condit. Reinf. active-inactive response ratio2.93.14.1-1.6-1.80.8-1.9-1.9-2.0-2.0-1.7
Condit. Reinf. active responses4.96.97.9-2.6-2.62.0-2.8-2.8-2.8-2.7-2.5
Condit. Reinf. inactive responses1.41.72.4-1.5-1.31.0-1.4-1.4-1.2-1.3-1.3
Condit. Reinf. lever presses7.09.510.6-3.3-3.13.0-3.2-3.2-3.1-3.1-2.9
Condit. Reinf. lever reinforcers received6.08.59.5-2.8-2.92.5-3.1-3.1-3.1-3.0-2.7
Conditioned reinforcement - actives0.80.81.2-0.5-0.81.0-1.1-1.1-1.0-0.7-0.5
Conditioned reinforcement - inactives2.02.34.2-1.5-1.52.1-1.3-1.3-1.4-1.4-1.3
Conditioned locomotion0.50.61.21.10.9-0.30.50.50.50.91.0
Patch foraging indifference point 0 sec0.40.60.8-0.9-0.70.7-0.8-0.8-0.8-0.7-0.6
Patch foraging indifference point AUC0.81.02.20.70.7-1.51.11.11.10.90.5
Delay disc. indifference point, 0s delay0.50.61.4-1.2-0.8-0.5-0.6-0.6-0.5-0.7-0.9
Delay disc. indifference point, 16s delay1.31.32.0-1.4-1.21.1-1.1-1.1-1.1-1.1-1.3
Delay disc. indifference point, 2s delay0.10.10.20.10.2-0.40.30.30.40.20.1
Delay disc. indifference point, 24s delay0.90.91.7-1.3-1.01.3-0.5-0.5-0.4-0.8-1.2
Delay disc. indifference point, 4s delay0.10.10.2-0.4-0.3-0.0-0.2-0.2-0.2-0.2-0.3
Delay disc. indifference point, 8s delay1.41.42.70.91.1-1.61.21.21.31.11.0
Indifference point function ln k0.81.12.9-0.8-0.81.7-1.0-1.0-1.1-0.8-0.6
Indifference point function log k0.81.12.9-0.8-0.81.7-1.0-1.0-1.1-0.8-0.6
Patch foraging total patch changes 0 sec0.50.70.9-1.0-0.80.9-0.9-0.9-0.9-0.8-0.7
Patch foraging total patch changes 12 sec0.20.30.9-0.9-0.60.1-0.4-0.4-0.4-0.5-0.7
Patch foraging total patch changes 18 sec0.50.62.90.20.4-1.70.70.70.80.50.2
Patch foraging total patch changes 24 sec0.40.51.1-1.1-0.80.4-0.6-0.6-0.5-0.7-0.9
Patch foraging total patch changes 6 sec0.10.10.4-0.6-0.4-0.4-0.2-0.2-0.2-0.3-0.4
Patch foraging time to switch 0 sec1.42.13.01.11.4-1.41.61.61.71.51.3
Patch foraging water rate 0 sec0.30.51.01.00.80.50.70.70.50.80.8
Patch foraging water rate 12 sec0.91.34.2-0.9-1.02.1-0.9-0.9-1.1-1.0-0.9
Patch foraging water rate 18 sec0.50.71.41.11.00.30.70.70.60.91.2
Patch foraging water rate 24 sec0.60.82.3-0.3-0.71.5-0.9-0.9-1.0-0.8-0.4
Patch foraging water rate 6 sec0.20.32.00.1-0.21.4-0.3-0.3-0.4-0.2-0.1
Seeking ratio, delayed vs. immediate footshock0.91.11.3-1.2-1.00.8-1.1-1.1-1.1-1.1-0.9
Distance traveled before self-admin1.81.92.4-1.4-1.41.3-1.5-1.5-1.6-1.5-1.0
Distance traveled after self-admin5.35.97.0-2.3-2.52.1-2.5-2.5-2.6-2.4-2.5
Extensor digitorum longus weight0.10.60.80.70.9-0.70.70.70.80.80.9
Bone: elastic displacement0.00.00.10.10.2-0.10.20.20.30.30.2
Bone: elastic work2.33.03.7-1.8-1.71.9-1.7-1.7-1.6-1.7-1.7
Bone: endosteal estimation1.02.33.0-1.7-1.60.8-1.5-1.5-1.5-1.5-1.7
Bone: endosteal perimeter0.92.02.4-1.6-1.51.1-1.4-1.4-1.4-1.4-1.5
Epididymis fat weight0.00.00.1-0.10.1-0.30.20.20.20.1-0.0
Delta time in closed arm before/after self-admin0.80.81.7-1.1-0.91.3-0.7-0.7-0.7-0.6-0.9
Delta time in open arm before/after self-admin0.10.10.30.60.4-0.10.10.10.10.10.6
Diff in mean of infusions in LGA sessions0.10.10.5-0.1-0.1-0.7-0.1-0.10.1-0.2-0.1
Delay discount exponential model param0.00.00.10.30.10.3-0.1-0.1-0.20.00.2
Extinction: sum of active levers before priming1.01.01.5-1.2-1.1-0.1-1.0-1.0-0.9-1.1-1.0
Active lever presses in extinction session 60.30.20.5-0.7-0.6-0.1-0.3-0.3-0.4-0.4-0.7
Bone: final force1.62.62.8-1.7-1.71.5-1.6-1.6-1.5-1.6-1.7
Bone: final moment2.54.14.3-2.0-2.11.9-2.1-2.1-1.9-2.0-2.1
Food consumed during 24 hour testing period0.50.61.8-0.6-0.61.3-0.7-0.7-0.7-0.7-0.5
Glucose0.30.50.70.40.60.60.80.80.80.80.5
Heart weight0.81.11.7-0.9-1.11.1-1.0-1.0-1.3-1.1-1.0
Delay discount hyperbolic model param0.00.00.20.1-0.00.4-0.2-0.2-0.3-0.10.1
Intermittent access intake day 1-15 change1.11.12.4-1.5-1.20.6-0.7-0.7-0.7-0.9-1.5
Intermittent access intake escalation0.90.91.6-1.3-1.00.6-0.8-0.8-0.7-0.9-1.2
Intermittent access intake escalation 22.72.64.0-2.0-1.80.4-1.5-1.5-1.5-1.7-1.9
Intermitt. access day 1 inactive lever presses0.60.62.7-0.8-0.61.6-0.5-0.5-0.5-0.4-0.7
Intermitt. access day 15 inactive lever presses0.40.42.6-0.5-0.41.6-0.2-0.2-0.3-0.2-0.6
Intermitt. access escalation Index0.40.30.8-0.0-0.3-0.1-0.9-0.9-0.8-0.6-0.0
Intermittent access day 1 total infusions0.50.61.40.50.01.2-0.9-0.9-0.9-0.40.6
Intermittent access day 15 total infusions1.31.42.1-0.9-1.01.4-1.4-1.4-1.3-1.2-0.7
Intermittent access terminal intake (last 3 days)1.71.92.2-1.2-1.31.5-1.5-1.5-1.5-1.4-1.1
Intermittent access total infusions1.21.32.4-0.5-0.81.5-1.4-1.4-1.3-1.1-0.5
Intermittent access day 1 locomotion0.70.71.30.2-0.21.1-1.1-1.1-1.2-0.40.3
Intermittent access day 15 total locomotion0.10.10.4-0.2-0.10.6-0.2-0.2-0.40.00.0
Intermittent access total locomotion0.10.10.30.50.30.4-0.0-0.0-0.10.40.5
Intermittent access standard deviation3.73.94.8-2.2-2.21.1-2.0-2.0-1.8-2.2-2.1
Left kidney weight3.08.49.2-2.9-2.93.0-2.8-2.8-2.8-2.8-3.0
Right kidney weight4.111.412.8-3.6-3.53.2-3.2-3.2-3.4-3.3-3.6
Cocaine induced anxiety0.00.00.20.00.0-0.50.30.30.10.00.0
Post-drug Anxiety0.40.51.00.50.5-1.00.80.80.60.70.4
Baseline Anxiety0.10.10.10.40.3-0.0-0.1-0.1-0.10.20.4
Tail length4.613.816.7-4.0-3.93.6-3.4-3.4-3.5-3.6-4.1
Length with tail6.925.229.9-5.5-5.25.4-4.6-4.6-4.6-4.8-5.4
Length without tail3.37.110.1-2.8-2.73.2-2.5-2.5-2.4-2.6-2.7
Times rat made contact with spout0.40.51.20.60.6-1.10.70.70.60.60.5
Lifetime Intake0.50.51.10.0-0.31.1-1.0-1.0-0.8-0.60.1
Liver weight, left0.00.00.1-0.20.1-0.30.20.20.20.2-0.0
Liver weight, right0.00.00.2-0.3-0.10.50.00.0-0.1-0.1-0.1
Locomotor activity0.61.01.50.60.8-1.21.21.21.10.90.6
Locomotor testing distance1.01.72.21.21.2-1.51.31.31.21.21.2
Locomotor testing rearing1.92.97.61.31.4-2.81.71.71.41.41.4
Locomotion in novel chamber0.50.62.00.50.6-1.40.60.60.60.60.6
Locomotion in novel chamber post-restriction0.00.00.20.40.10.10.10.1-0.00.00.1
Fecal boli incidents, locomotor time 12.42.63.41.71.8-0.71.61.61.51.81.8
Change in fecal boli incidents, locomotor task0.40.31.0-0.3-0.4-1.0-0.6-0.6-0.6-0.6-0.3
Time >=10cm from walls, locomotor time 10.00.00.00.10.1-0.00.10.1-0.10.20.1
Bouts of movement, locomotor time 10.20.20.4-0.3-0.4-0.3-0.4-0.4-0.7-0.3-0.4
Total resting periods, locomotor time 10.10.10.5-0.2-0.3-0.1-0.4-0.4-0.7-0.2-0.2
Rest time, locomotor task time 10.00.00.10.20.10.20.00.0-0.20.20.2
Distance moved, locomotor task time 10.10.10.3-0.5-0.30.0-0.2-0.2-0.0-0.4-0.4
Vertical activity count, locomotor time 11.01.01.3-1.1-1.10.5-1.1-1.1-0.9-1.1-1.1
Time >=10cm from walls, locomotor time 20.00.00.1-0.3-0.1-0.20.00.00.1-0.0-0.2
Bouts of movement, locomotor time 20.10.10.3-0.00.30.20.50.50.20.60.2
Total resting periods, locomotor time 20.10.10.40.10.30.10.50.50.20.60.3
Rest time, locomotor task time 20.30.30.6-0.0-0.40.8-0.6-0.6-0.7-0.5-0.3
Distance moved, locomotor task time 20.10.10.8-0.20.1-0.90.20.20.30.1-0.0
Vertical activity count, locomotor time 20.20.20.5-0.7-0.4-0.7-0.2-0.2-0.1-0.3-0.5
Light reinforcement 10.30.51.00.10.5-0.61.01.00.90.70.4
Light reinforcement 26.28.29.83.13.1-1.82.82.82.93.03.1
Bone: marrow area1.12.43.1-1.8-1.60.8-1.6-1.6-1.5-1.5-1.7
Bone: maximum diameter1.52.83.1-1.8-1.71.8-1.7-1.7-1.5-1.5-1.7
Bone: maximum force2.74.75.3-2.2-2.21.6-2.3-2.3-2.1-2.2-2.2
Bone: maximum moment3.76.37.3-2.6-2.62.0-2.7-2.7-2.4-2.5-2.6
Mean time between licks in bursts0.20.20.4-0.6-0.50.6-0.5-0.5-0.4-0.5-0.4
Mean num. licks in bursts0.70.81.5-1.2-1.0-0.4-0.7-0.7-0.8-0.9-1.2
Cd content in liver0.70.72.80.80.7-1.70.60.60.60.60.7
Co content in liver1.61.82.51.51.5-1.11.01.01.51.41.6
Cu content in liver1.51.83.7-1.2-1.21.9-1.3-1.3-1.2-1.2-1.2
Fe content in liver0.40.50.70.50.7-0.10.90.90.80.80.6
K content in liver0.90.81.6-0.9-0.91.3-0.8-0.8-0.9-0.8-0.9
Mg content in liver0.20.21.1-0.2-0.21.0-0.2-0.2-0.3-0.3-0.2
Mn content in liver0.60.70.9-0.6-0.80.5-0.9-0.9-0.9-0.9-0.8
Na content in liver5.55.87.0-2.6-2.52.2-2.3-2.3-2.4-2.4-2.6
Rb content in liver0.00.00.1-0.3-0.10.20.10.1-0.10.0-0.1
Se content in liver3.23.94.42.11.9-1.92.02.02.01.91.8
Sr content in liver0.60.51.01.00.8-0.50.40.40.80.70.9
Zn content in liver0.30.30.50.70.60.10.50.50.60.60.6
Bone: minimum diameter5.19.611.3-3.2-3.31.4-3.4-3.4-3.2-3.3-3.2
Time in familiar zone, hab. session 10.30.30.5-0.7-0.50.0-0.6-0.6-0.4-0.5-0.6
Time in novel zone, hab. session 10.10.10.30.50.3-0.10.40.40.20.30.4
Total zone transitions, hab. session 10.50.71.3-1.1-0.9-0.5-0.7-0.7-0.8-0.9-1.0
Total locomotion distance, hab. session 12.53.65.3-2.3-2.10.2-1.8-1.8-2.0-2.1-2.1
Locomotion velocity, hab. session 11.01.52.4-1.5-1.4-0.1-1.1-1.1-1.3-1.3-1.3
Time in familiar zone, hab. session 20.30.30.4-0.5-0.60.6-0.5-0.5-0.5-0.6-0.5
Time in novel zone, hab. session 20.60.60.90.60.7-0.70.90.90.70.80.7
Total zone transitions, hab. session 20.00.00.10.10.1-0.20.30.30.10.10.2
Total locomotion distance, hab. session 20.30.40.7-0.8-0.80.1-0.6-0.6-0.8-0.8-0.7
Locomotion velocity, hab. session 20.30.40.6-0.7-0.70.1-0.6-0.6-0.7-0.8-0.6
Novel to familiar place preference ratio0.90.91.6-1.1-1.1-0.1-0.7-0.7-1.1-1.0-1.3
Novelty place preference0.80.81.4-1.1-1.10.1-0.6-0.6-1.0-0.9-1.2
Time in novel zone, NPP test0.50.50.9-0.8-0.9-0.1-0.4-0.4-0.8-0.7-1.0
Total zone transitions, NPP test0.10.20.40.20.4-0.40.60.60.50.50.4
Total locomotion distance, NPP test1.31.82.5-1.6-1.50.4-1.3-1.3-1.4-1.5-1.4
Locomotion velocity, NPP test1.72.53.3-1.8-1.70.6-1.5-1.5-1.7-1.7-1.7
Intraocular pressure0.10.10.20.40.30.20.20.20.50.40.2
Delta distance traveled before/after self-admin0.50.51.4-0.7-0.90.4-0.6-0.6-0.7-0.6-1.2
Delta ambulatory time before/after self-admin1.21.32.1-1.0-1.20.7-1.2-1.2-1.2-1.1-1.5
Parametrial fat weight0.40.81.01.01.0-0.30.90.90.91.01.0
Pavlov. Cond. lever latency0.20.30.40.70.5-0.50.50.50.40.50.5
Pavlov. Cond. magazine entry latency0.10.10.20.30.40.10.20.20.30.30.5
Pavlov. Cond. change in total contacts0.00.00.1-0.1-0.00.2-0.3-0.3-0.1-0.0-0.0
Pavlov. Cond. index score0.00.10.1-0.3-0.10.3-0.3-0.3-0.1-0.2-0.1
Pavlov. Cond. latency score0.10.10.2-0.4-0.30.4-0.4-0.4-0.3-0.3-0.3
Pavlov. Cond. lever contacts1.01.21.7-1.3-1.01.2-1.1-1.1-0.9-1.0-1.1
Pavlov. Cond. magazine entry number0.00.00.1-0.2-0.20.1-0.0-0.0-0.1-0.1-0.3
Pavlov. Cond. intertrial magazine entries0.10.20.50.50.3-0.70.30.30.30.40.3
Pavlov. Cond. lever-magazine prob. diff.0.20.20.3-0.5-0.40.6-0.6-0.6-0.3-0.4-0.3
Pavlov. Cond. response bias0.20.20.3-0.5-0.40.5-0.5-0.5-0.4-0.4-0.3
Pavlov. Cond. lever latency3.14.14.42.12.0-1.92.12.12.12.11.9
Pavlov. Cond. magazine entry latency2.02.35.0-1.5-1.42.2-1.4-1.4-1.4-1.3-1.3
Pavlov. Cond. change in total contacts5.88.08.7-2.9-2.92.4-3.0-3.0-2.9-2.9-2.7
Pavlov. Cond. index score2.93.74.6-2.1-1.92.2-1.9-1.9-1.9-1.9-1.8
Pavlov. Cond. latency score2.83.54.8-2.0-1.82.2-1.8-1.8-1.8-1.8-1.7
Pavlov. Cond. lever contacts2.94.04.4-2.1-2.01.8-2.1-2.1-2.0-2.0-1.9
Pavlov. Cond. magazine entry number1.11.42.81.31.1-1.71.11.11.01.01.1
Pavlov. Cond. intertrial magazine entries0.81.01.41.21.0-0.31.11.11.01.01.1
Pavlov. Cond. lever-magazine prob. diff.3.44.35.2-2.2-2.02.3-2.1-2.1-2.0-2.0-2.0
Pavlov. Cond. response bias3.44.75.0-2.2-2.12.1-2.2-2.2-2.2-2.2-2.0
Time in closed arm before self-admin0.10.10.50.60.4-0.30.00.00.10.00.7
Time in closed arm after self-admin0.40.41.2-0.6-0.51.1-0.7-0.7-0.6-0.5-0.2
Time in open arm before self-admin1.21.31.9-1.3-1.21.2-0.9-0.9-1.0-1.0-1.4
Time in open arm after self-admin0.60.60.8-0.8-0.90.4-0.8-0.8-0.9-0.8-0.9
Bone: periosteal estimation1.93.94.6-2.1-2.11.2-2.1-2.1-1.9-2.0-2.1
Bone: periosteal perimeter1.62.63.1-1.8-1.71.0-1.7-1.7-1.6-1.6-1.8
Bone: post-yield work0.60.81.1-0.9-0.90.3-0.9-0.9-1.1-1.0-0.9
Progressive ratio test 1 active lever presses3.03.14.9-1.1-1.32.2-2.2-2.2-2.0-1.7-0.8
Progressive ratio test 1 breakpoint3.33.45.1-1.4-1.52.3-2.2-2.2-2.2-1.8-1.0
Progressive ratio test 1 inactive lever presses0.80.82.1-0.4-0.71.5-1.1-1.1-1.0-0.6-0.5
Progressive ratio test 2 active lever presses1.31.43.0-0.8-0.91.7-1.3-1.3-1.3-1.0-0.6
Progressive ratio test 2 breakpoint1.41.53.5-0.8-0.91.9-1.4-1.4-1.4-1.0-0.6
Progressive ratio test 2 inactive lever presses3.23.75.8-1.7-1.82.4-2.0-2.0-2.0-1.7-1.6
Incentive Sensitization - Responses0.10.10.4-0.2-0.10.60.10.10.00.2-0.1
Incentive Sensitization - Breakpoint0.10.10.10.00.10.30.40.40.30.40.1
Sum of active levers in priming session hrs 5-60.40.43.1-0.1-0.1-1.80.10.10.1-0.1-0.1
Progressive ratio0.50.61.60.60.6-1.30.80.80.80.80.4
Food seeking constrained by brief footshock2.93.64.8-1.8-2.01.0-2.1-2.1-2.2-2.0-1.8
Seeking ratio, punishment vs. effort2.12.63.7-1.3-1.41.9-1.8-1.8-1.8-1.7-1.1
Retroperitoneal fat weight1.03.24.51.51.7-1.22.12.12.01.91.5
Reaction time number correct0.10.10.2-0.1-0.30.3-0.4-0.4-0.5-0.4-0.2
Reaction time mean minus median0.30.30.8-0.5-0.60.9-0.4-0.4-0.6-0.6-0.4
Reaction time mean minus median AUC0.50.61.8-0.7-0.71.3-0.6-0.6-0.8-0.7-0.6
Reaction time num false alarms0.60.81.21.01.0-1.10.50.50.81.01.0
Reaction time num false alarms AUC0.91.21.61.21.2-1.30.70.71.01.21.2
Reaction time trials correct on left0.10.10.2-0.1-0.30.3-0.4-0.4-0.5-0.4-0.2
Reaction time trials on left0.10.10.2-0.0-0.30.3-0.3-0.3-0.5-0.3-0.2
Reaction time mean0.00.10.20.30.20.50.00.00.10.10.3
Reaction time mean AUC0.10.10.40.40.40.60.20.20.20.30.5
Median of all reaction times0.10.10.30.50.50.20.20.20.30.30.5
Reaction time omissions0.10.10.30.50.4-0.20.10.10.10.20.5
Reaction time false alarm rate0.91.31.61.11.2-1.10.90.91.21.31.2
Reaction time premature initiation rate0.00.00.00.00.0-0.20.00.00.10.00.0
Reaction time premature initiations0.00.00.00.0-0.1-0.1-0.1-0.1-0.1-0.1-0.0
Std. dev. reaction times0.20.31.1-0.2-0.41.0-0.4-0.4-0.5-0.4-0.2
Reaction time trials completed0.10.10.2-0.0-0.30.3-0.3-0.3-0.5-0.3-0.2
Reaction time trials AUC0.00.10.10.1-0.20.2-0.3-0.3-0.4-0.3-0.0
Run reversals in cocaine runway, females0.30.30.50.50.50.70.50.50.50.60.4
Run reversals in cocaine runway, males1.11.01.71.21.2-0.80.90.90.80.91.3
Latency to leave start box in cocaine runway0.20.20.50.20.2-0.20.70.70.70.5-0.1
Latency to leave start box in cocaine runway, F0.70.81.20.80.7-1.01.11.11.10.90.3
Latency to leave start box in cocaine runway, M0.10.10.4-0.2-0.20.6-0.2-0.2-0.1-0.1-0.2
Std. dev. time between licks in bursts0.50.71.1-1.1-0.90.2-0.8-0.8-0.7-0.8-1.0
Total sessions with >9 infusions0.20.20.70.2-0.00.1-0.8-0.8-0.5-0.30.2
Short access day 1 total inactive lever presses0.50.61.4-0.7-0.71.2-0.7-0.7-0.7-0.6-0.7
Short access day 10 total inactive lever presses0.30.31.0-0.5-0.61.0-0.5-0.5-0.5-0.4-0.5
Short access day 1 total infusions0.60.61.1-0.4-0.51.0-1.0-1.0-1.0-0.8-0.2
Short access day 10 total infusions0.20.20.40.60.20.3-0.4-0.4-0.3-0.10.6
Short access total infusions0.20.20.30.50.30.4-0.5-0.5-0.4-0.00.6
Short access day 1 locomotion0.91.01.20.91.0-1.10.90.90.81.11.1
Short access day 10 total locomotion1.11.22.0-0.9-1.00.9-1.4-1.4-1.3-1.0-0.8
Short access total locomotion0.10.10.30.10.00.1-0.6-0.6-0.5-0.00.2
One hour access (0.3 mA shock)1.92.23.0-1.3-1.41.3-1.7-1.7-1.6-1.5-1.2
Compulsive drug intake0.20.20.3-0.4-0.5-0.3-0.5-0.5-0.5-0.5-0.5
One hour access (shock baseline)0.50.51.3-0.5-0.61.1-0.8-0.8-0.7-0.6-0.4
Social response proportion5.15.56.8-2.1-2.32.1-2.5-2.5-2.6-2.5-2.1
Social responses0.10.20.7-0.4-0.30.8-0.2-0.2-0.4-0.3-0.3
Social time0.20.20.4-0.6-0.60.1-0.3-0.3-0.6-0.6-0.7
Soleus weight1.03.05.81.41.6-2.41.61.61.71.61.6
Bone: stiffness1.32.12.6-1.4-1.50.8-1.6-1.6-1.4-1.5-1.5
Tibialis anterior weight0.00.10.9-0.3-0.1-0.9-0.0-0.0-0.1-0.1-0.1
Time to tail flick, vehicle, before self-admin0.30.30.9-0.7-0.50.9-0.5-0.5-0.3-0.4-0.6
Time to tail flick, vehicle, after self-admin0.30.31.1-0.2-0.31.1-0.6-0.6-0.6-0.40.1
Time to tail flick, test, before self-admin0.10.10.3-0.5-0.20.0-0.1-0.1-0.2-0.1-0.4
Time to tail flick, test, after self-admin0.10.10.2-0.2-0.30.4-0.4-0.4-0.5-0.3-0.4
Delta time to tail flick, vehicle, before/after SA0.10.10.20.0-0.10.4-0.4-0.4-0.5-0.30.2
Delta time to tail flick, test, before/after SA0.00.00.10.30.00.3-0.1-0.1-0.1-0.10.1
Tibia length2.26.27.2-2.5-2.52.7-2.5-2.5-2.4-2.4-2.4
Ambulatory time before self-admin0.91.01.5-1.0-1.00.8-1.0-1.0-1.2-1.1-0.5
Ambulatory time after self-admin5.25.76.5-2.2-2.52.1-2.4-2.4-2.6-2.5-2.4
Bone: tissue strength4.44.35.2-1.9-2.11.7-2.3-2.3-2.1-2.1-2.1
Total heroin consumption1.21.31.7-1.2-1.3-0.8-1.1-1.1-1.2-1.3-1.1
Bone: trabecular number0.10.20.3-0.6-0.40.6-0.5-0.5-0.2-0.2-0.5
Bone: trabecular spacing1.51.92.5-1.4-1.50.7-1.3-1.3-1.6-1.6-1.4
Bone: trabecular thickness0.20.20.30.30.40.60.30.30.50.60.3
Bone: trabecular tissue density2.73.94.21.92.0-1.92.02.02.02.01.9
Water consumed over 24 hours0.91.11.8-1.0-1.11.3-1.0-1.0-1.0-1.1-1.1
Number of responses in last shaping day2.12.12.3-1.5-1.51.5-1.4-1.4-1.5-1.5-1.4