Hub : Genes

Hmgcr

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Hmgcr 0.02 0.02 3.8e-03 0.02 0.02 0.01 0.01 4.2e-03 2.4e-03 2.0e-02 1.5e-02
2 RMTg alternative TSS XM_063281376.1 0.51 0.18 5.4e-03 0.11 0.13 0.09 0.09 9.7e-04 2.2e-04 1.8e-03 1.8e-03
3 Brain isoform ratio XM_006231826.5 0.07 0.07 7.7e-05 0.04 0.02 0.02 0.04 1.3e-04 4.0e-03 4.3e-03 7.5e-05
4 pVTA gene expression Hmgcr 0.17 0.13 1.1e-06 0.09 0.06 0.08 0.08 2.0e-07 1.2e-05 3.6e-07 3.1e-07
5 RMTg alternative TSS XM_006231826.5 0.47 0.19 8.2e-03 0.1 0.12 0.11 0.09 1.2e-03 4.4e-04 7.4e-04 2.2e-03
6 PL gene expression Hmgcr 0.05 0.05 1.2e-03 0.03 0.01 0.01 0.02 6.6e-04 8.8e-03 1.6e-02 2.4e-03
7 Brain isoform ratio NM_013134.2 0.05 0.04 6.9e-05 0.04 0.04 0.03 0.03 3.2e-04 2.1e-04 3.3e-04 4.3e-04
8 Liver gene expression Hmgcr 0.1 0.07 4.3e-07 0.03 0.03 0.03 0.03 9.6e-05 1.6e-04 3.0e-04 2.6e-04
9 Brain mRNA stability Hmgcr 0.04 0.04 2.5e-03 0.03 0.02 0.03 0.03 1.2e-03 2.9e-03 1.4e-03 1.7e-03
10 Adipose mRNA stability Hmgcr 0.04 0.03 6.8e-04 0.02 0.02 0.01 0.01 2.8e-03 6.0e-03 7.9e-03 7.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.30.51.20.60.9-0.50.5-0.91.10.40.5-0.5-0.6
Area under the delay curve0.70.81.4-1.10.11.2-0.7-0.0-0.9-1.0-0.90.81.1
BMI with tail1.65.66.8-2.6-1.92.6-2.52.0-2.5-2.4-2.42.32.5
BMI without tail1.64.85.5-2.3-2.22.2-2.32.2-2.3-2.2-2.12.02.0
Body weight2.19.211.5-3.3-2.43.3-3.02.5-3.4-3.0-3.03.03.3
Weight adjusted by age0.10.10.40.3-0.6-0.2-0.10.5-0.10.1-0.1-0.1-0.2
Bone surface0.00.10.40.10.60.00.0-0.60.20.10.1-0.0-0.2
Bone volume0.61.12.30.91.5-0.80.7-1.41.50.70.8-0.7-0.9
Breakpoint value in progressive ratio session0.20.30.40.50.5-0.70.7-0.50.60.20.6-0.5-0.4
Number of licking bursts0.10.10.5-0.3-0.70.3-0.20.7-0.2-0.2-0.20.20.1
Context. condit. distance diff. score1.41.72.81.21.2-1.31.4-1.20.91.21.4-1.7-1.5
Locomotion velocity, session 10.40.40.80.7-0.0-0.70.6-0.10.80.60.9-0.3-0.9
Locomotion distance, session 10.81.01.51.20.8-1.11.0-0.91.01.21.2-0.7-0.9
Locomotion velocity, session 20.20.30.80.50.5-0.60.3-0.50.90.20.5-0.3-0.4
Locomotion distance, session 21.21.72.21.41.1-1.41.3-1.11.41.21.5-1.1-1.2
Locomotion velocity, session 31.72.03.41.51.0-1.71.5-1.11.21.31.5-1.8-1.2
Locomotion distance, session 31.21.32.71.10.9-1.21.3-0.90.41.21.2-1.6-1.1
Stereotopy head waving bouts, day 31.31.62.51.40.5-1.21.4-0.61.21.31.6-1.2-1.6
Stereotopy head waving duration, day 30.10.10.30.2-0.60.2-0.00.50.20.00.20.4-0.3
Locomotion velocity, session 70.91.01.90.81.4-0.80.9-1.30.90.61.0-1.1-1.0
Locomotion distance, session 70.10.10.4-0.20.60.10.0-0.50.0-0.30.1-0.1-0.1
Stereotopy head waving bouts, day 72.52.94.91.70.7-1.82.1-0.91.11.81.8-2.2-1.9
Stereotopy head waving duration, day 70.70.91.61.00.0-1.11.2-0.10.71.01.0-1.3-1.1
Locomotion velocity, session 83.84.68.42.21.9-2.32.0-1.92.91.72.2-2.0-2.2
Locomotion distance, session 81.52.13.11.41.4-1.61.5-1.41.31.31.6-1.7-1.4
Degree of sensitization distance0.90.92.0-1.0-0.41.1-1.10.4-0.3-1.1-1.01.40.9
Degree of sensitization stereotypy2.22.44.81.50.6-1.71.9-0.71.11.61.6-2.2-1.7
Conditioned locomotion0.10.10.50.0-0.0-0.00.30.0-0.70.40.2-0.40.0
Cocaine response after cond. corrected0.30.31.3-0.3-1.2-0.0-0.21.1-0.4-0.4-0.30.00.3
Cocaine response after cond. not corrected0.50.61.3-0.8-1.10.4-0.71.1-0.7-0.9-0.70.40.7
Cocaine response before conditioning0.10.10.6-0.40.80.3-0.2-0.7-0.0-0.3-0.10.00.1
Saline control response0.81.11.9-1.1-1.11.1-1.01.1-1.4-0.9-0.91.00.9
Bone: connectivity density0.10.10.20.30.3-0.20.3-0.30.50.20.3-0.3-0.4
Bone: cortical apparent density3.34.67.32.02.1-2.42.2-2.11.52.02.1-2.7-2.0
Bone: cortical area0.30.51.90.51.4-0.40.2-1.30.80.60.2-0.3-0.1
Bone: cortical porosity0.00.00.10.00.3-0.10.3-0.2-0.10.1-0.1-0.10.2
Bone: cortical porosity0.10.20.40.30.5-0.40.6-0.50.00.40.3-0.5-0.1
Bone: cortical thickness0.91.53.11.21.8-1.21.0-1.71.01.30.7-1.3-0.6
Bone: cortical thickness0.80.92.0-1.0-0.31.0-1.00.4-1.1-0.7-1.20.81.4
Bone: cortical tissue density3.34.57.12.02.1-2.32.2-2.11.52.02.1-2.7-2.1
Condit. Reinf. active minus inactive responses0.10.10.20.20.2-0.3-0.0-0.20.20.2-0.1-0.40.5
Condit. Reinf. active-inactive response ratio0.10.10.3-0.1-0.5-0.3-0.10.5-0.3-0.0-0.3-0.30.6
Condit. Reinf. active responses0.20.20.7-0.00.9-0.1-0.2-0.80.30.1-0.4-0.10.8
Condit. Reinf. inactive responses0.30.41.4-0.21.20.3-0.3-1.10.5-0.2-0.30.40.5
Incentive salience index mean0.20.31.2-0.40.30.3-0.5-0.2-0.2-0.2-0.70.31.1
Condit. Reinf. lever presses0.10.20.8-0.10.90.2-0.0-0.80.00.1-0.30.10.6
Condit. Reinf. active minus inactive responses0.10.10.3-0.30.60.2-0.4-0.50.2-0.4-0.10.10.2
Condit. Reinf. active-inactive response ratio0.40.40.8-0.80.20.7-0.7-0.1-0.2-0.9-0.70.70.8
Condit. Reinf. active responses0.20.21.00.11.0-0.2-0.1-0.90.7-0.00.3-0.2-0.2
Condit. Reinf. inactive responses0.10.10.3-0.20.00.3-0.5-0.00.1-0.3-0.30.40.2
Condit. Reinf. lever presses0.20.31.6-0.11.30.1-0.1-1.10.4-0.20.1-0.10.1
Condit. Reinf. lever reinforcers received0.10.20.8-0.00.90.0-0.2-0.80.4-0.10.2-0.1-0.1
Conditioned reinforcement - actives0.30.51.1-0.8-1.00.6-0.61.0-0.4-1.0-0.50.70.3
Conditioned reinforcement - inactives0.00.10.2-0.2-0.1-0.00.20.1-0.40.20.4-0.3-0.3
Conditioned locomotion1.01.32.10.71.4-0.91.3-1.41.00.81.4-1.1-1.2
Patch foraging indifference point 0 sec0.61.12.2-1.4-1.01.1-0.81.0-1.5-1.2-0.80.80.7
Patch foraging indifference point AUC1.01.41.9-1.2-0.81.2-1.30.8-1.2-1.1-1.41.21.4
Delay disc. indifference point, 0s delay0.00.00.1-0.00.30.1-0.2-0.30.20.1-0.3-0.00.0
Delay disc. indifference point, 16s delay0.20.30.6-0.70.30.6-0.2-0.2-0.7-0.5-0.40.30.8
Delay disc. indifference point, 2s delay0.20.20.5-0.40.70.5-0.1-0.6-0.1-0.4-0.30.20.6
Delay disc. indifference point, 24s delay1.82.03.8-1.70.02.0-1.40.2-0.9-1.8-1.41.61.8
Delay disc. indifference point, 4s delay0.10.10.2-0.20.30.4-0.3-0.2-0.1-0.2-0.40.20.1
Delay disc. indifference point, 8s delay1.61.82.6-1.5-0.81.6-1.20.8-1.3-1.5-1.41.51.6
Indifference point function ln k0.10.30.40.40.6-0.50.5-0.60.50.30.6-0.5-0.5
Indifference point function log k0.10.30.40.40.6-0.50.5-0.60.50.30.6-0.5-0.5
Patch foraging total patch changes 0 sec0.61.12.1-1.4-1.01.1-0.81.0-1.5-1.2-0.80.80.7
Patch foraging total patch changes 12 sec1.51.92.6-1.5-0.81.6-1.50.8-1.5-1.4-1.51.51.4
Patch foraging total patch changes 18 sec0.91.32.4-1.6-0.71.5-1.10.8-1.4-1.4-0.91.00.9
Patch foraging total patch changes 24 sec2.03.55.9-2.3-1.72.0-1.61.7-2.4-2.0-1.71.41.6
Patch foraging total patch changes 6 sec0.91.42.1-1.3-0.81.2-1.30.9-0.8-1.4-1.41.31.3
Patch foraging time to switch 0 sec0.00.10.30.3-0.20.1-0.20.20.5-0.1-0.20.2-0.1
Patch foraging water rate 0 sec0.10.10.8-0.2-0.2-0.10.30.2-0.90.20.2-0.30.2
Patch foraging water rate 12 sec0.61.22.90.60.7-1.21.3-0.80.11.11.4-1.7-1.1
Patch foraging water rate 18 sec0.60.93.3-1.3-0.60.7-0.70.6-1.8-0.8-0.80.31.2
Patch foraging water rate 24 sec0.50.71.5-1.1-0.20.9-0.80.2-1.2-0.8-0.70.81.2
Patch foraging water rate 6 sec1.01.52.70.51.6-0.81.5-1.6-0.11.11.5-1.4-0.9
Seeking ratio, delayed vs. immediate footshock0.10.20.7-0.2-0.10.4-0.50.10.00.1-0.60.40.8
Distance traveled before self-admin0.20.30.5-0.60.20.7-0.7-0.1-0.7-0.4-0.50.60.3
Distance traveled after self-admin2.53.04.5-1.7-1.41.6-2.11.4-2.1-1.4-2.01.81.8
Extensor digitorum longus weight0.10.20.70.20.60.4-0.2-0.50.80.0-0.00.70.0
Bone: elastic displacement1.31.52.21.01.3-1.21.4-1.21.30.91.2-1.1-1.5
Bone: elastic work0.40.51.00.70.8-0.61.0-0.80.60.70.8-0.6-0.7
Bone: endosteal estimation0.40.81.7-1.0-0.41.2-1.20.5-0.3-0.9-0.81.30.8
Bone: endosteal perimeter0.10.30.7-0.50.00.7-0.80.00.1-0.5-0.50.80.3
Epididymis fat weight2.37.811.1-2.7-3.32.6-2.73.3-2.9-2.5-2.82.32.6
Delta time in closed arm before/after self-admin1.00.91.40.71.2-0.90.9-1.20.21.01.0-1.0-1.0
Delta time in open arm before/after self-admin0.50.51.0-0.5-0.50.5-1.00.50.4-0.7-1.00.60.9
Diff in mean of infusions in LGA sessions1.21.52.70.91.6-0.91.2-1.51.60.71.1-1.0-1.3
Delay discount exponential model param0.70.81.51.1-0.1-1.20.7-0.00.91.00.8-0.8-1.1
Extinction: sum of active levers before priming0.00.00.2-0.10.1-0.10.3-0.1-0.1-0.10.2-0.5-0.1
Active lever presses in extinction session 60.20.20.80.30.9-0.20.5-0.8-0.00.40.4-0.4-0.3
Bone: final force0.10.10.3-0.00.30.3-0.5-0.2-0.0-0.1-0.40.50.5
Bone: final moment0.10.10.3-0.10.30.4-0.5-0.2-0.1-0.2-0.40.50.5
Food consumed during 24 hour testing period1.31.73.1-1.2-0.91.3-1.70.9-1.3-1.2-1.51.11.8
Glucose1.32.13.71.41.5-1.61.1-1.51.91.21.3-1.5-1.2
Heart weight1.21.92.8-1.4-1.41.2-1.31.5-1.7-1.6-1.21.21.3
Delay discount hyperbolic model param0.60.61.31.0-0.2-1.10.60.10.80.90.8-0.7-1.0
Intermittent access intake day 1-15 change0.10.10.20.2-0.3-0.20.40.2-0.40.40.3-0.2-0.4
Intermittent access intake escalation0.00.10.30.20.1-0.20.4-0.1-0.20.50.4-0.3-0.3
Intermittent access intake escalation 20.10.10.10.2-0.4-0.30.20.3-0.10.30.2-0.1-0.2
Intermitt. access day 1 inactive lever presses0.93.54.61.72.0-1.72.0-2.11.42.11.8-2.2-1.4
Intermitt. access day 15 inactive lever presses1.32.74.21.31.5-1.61.9-1.50.71.81.9-2.0-1.6
Intermitt. access escalation Index0.10.10.40.50.4-0.1-0.0-0.40.20.60.2-0.00.2
Intermittent access day 1 total infusions1.93.16.5-2.4-1.22.1-1.41.3-2.6-1.9-1.31.31.5
Intermittent access day 15 total infusions0.30.51.2-1.0-0.20.9-0.50.3-1.1-0.7-0.30.40.5
Intermittent access terminal intake (last 3 days)0.30.41.3-0.9-0.70.7-0.40.7-1.2-0.6-0.20.30.4
Intermittent access total infusions0.70.92.2-1.5-0.01.3-0.70.1-1.2-1.2-0.60.70.7
Intermittent access day 1 locomotion0.60.81.8-1.20.61.3-0.9-0.4-0.8-1.0-0.70.80.8
Intermittent access day 15 total locomotion1.11.93.8-1.9-1.21.4-1.11.3-2.0-1.6-1.00.91.0
Intermittent access total locomotion0.30.40.9-0.91.00.8-0.3-0.8-0.5-0.6-0.10.20.2
Intermittent access standard deviation0.00.10.3-0.0-0.2-0.10.10.1-0.50.3-0.1-0.20.1
Left kidney weight4.923.025.4-5.0-4.54.9-4.74.6-5.0-4.8-4.94.45.0
Right kidney weight5.324.227.4-5.2-4.54.9-5.14.6-4.8-5.1-5.04.65.2
Cocaine induced anxiety0.60.83.71.20.6-0.80.6-0.61.90.50.6-0.4-0.6
Post-drug Anxiety0.30.32.10.7-0.2-0.50.30.21.5-0.20.1-0.2-0.3
Baseline Anxiety0.20.20.7-0.7-0.20.5-0.20.2-0.8-0.5-0.40.10.1
Tail length0.72.73.2-1.7-1.71.6-1.81.7-1.6-1.6-1.61.71.6
Length with tail1.25.47.2-2.2-2.62.3-2.22.6-2.7-2.1-2.12.32.3
Length without tail1.24.05.8-2.0-1.62.2-2.01.6-2.4-1.7-2.02.02.3
Times rat made contact with spout2.83.34.3-1.7-2.11.4-1.82.1-2.0-1.7-1.81.22.0
Lifetime Intake0.60.82.0-1.4-0.01.3-0.70.2-1.2-1.1-0.50.60.6
Liver weight, left5.28.610.7-3.3-2.33.3-3.02.4-3.1-3.1-3.02.92.9
Liver weight, right1.62.94.9-2.0-0.72.2-1.80.8-1.8-1.5-1.81.81.8
Locomotor activity0.20.31.30.0-1.1-0.3-0.21.0-0.3-0.3-0.0-0.20.0
Locomotor testing distance1.12.05.5-1.0-2.30.7-1.32.3-1.1-1.5-1.00.71.0
Locomotor testing rearing0.40.93.3-0.6-1.80.1-0.71.8-0.7-1.0-0.40.20.5
Locomotion in novel chamber0.70.91.80.9-0.2-1.31.20.10.40.81.2-1.3-1.1
Locomotion in novel chamber post-restriction0.00.00.20.0-0.00.10.1-0.0-0.40.20.2-0.1-0.3
Fecal boli incidents, locomotor time 10.40.62.1-0.1-1.50.4-0.11.3-1.40.00.10.50.1
Change in fecal boli incidents, locomotor task1.01.02.60.81.1-0.80.7-1.11.60.51.0-0.9-0.9
Time >=10cm from walls, locomotor time 11.11.12.41.10.1-1.21.4-0.30.11.51.5-1.2-0.7
Bouts of movement, locomotor time 10.60.71.50.0-1.00.2-1.21.00.5-0.5-1.10.90.7
Total resting periods, locomotor time 10.80.91.9-0.0-1.10.3-1.41.00.5-0.6-1.41.10.8
Rest time, locomotor task time 10.40.51.01.0-0.6-0.80.20.50.70.70.6-0.3-1.0
Distance moved, locomotor task time 10.50.81.8-1.31.31.1-0.3-1.1-0.4-0.9-0.40.31.0
Vertical activity count, locomotor time 10.20.61.6-1.11.30.8-0.3-1.1-0.6-0.5-0.10.00.5
Time >=10cm from walls, locomotor time 20.10.10.40.2-0.0-0.50.5-0.00.20.30.5-0.6-0.0
Bouts of movement, locomotor time 20.10.10.40.50.2-0.50.2-0.20.60.40.0-0.5-0.2
Total resting periods, locomotor time 20.10.20.40.60.2-0.60.3-0.20.50.50.1-0.6-0.3
Rest time, locomotor task time 20.10.20.70.4-0.3-0.40.30.2-0.10.50.5-0.3-0.8
Distance moved, locomotor task time 20.30.40.7-0.80.90.6-0.4-0.7-0.1-0.7-0.60.10.8
Vertical activity count, locomotor time 20.10.20.6-0.80.50.4-0.3-0.4-0.6-0.4-0.0-0.20.4
Light reinforcement 10.82.03.3-1.0-1.81.1-1.71.8-0.4-1.4-1.51.61.5
Light reinforcement 20.50.81.3-0.6-0.71.0-1.00.7-0.8-0.4-1.01.11.1
Bone: marrow area0.40.81.8-1.0-0.41.2-1.20.5-0.4-0.9-0.81.30.8
Bone: maximum diameter0.40.81.3-0.9-0.11.1-1.10.2-0.6-0.8-1.01.10.9
Bone: maximum force0.20.30.6-0.4-0.10.6-0.80.1-0.3-0.5-0.60.70.6
Bone: maximum moment0.20.30.6-0.4-0.10.7-0.80.1-0.4-0.5-0.60.80.6
Mean time between licks in bursts0.71.72.1-1.4-1.11.4-1.21.2-1.4-1.5-1.31.31.2
Mean num. licks in bursts0.40.61.4-0.7-0.50.6-1.00.5-0.9-0.8-1.00.51.2
Cd content in liver0.00.00.10.00.3-0.20.1-0.3-0.00.00.2-0.1-0.2
Co content in liver0.10.10.3-0.30.10.1-0.5-0.00.2-0.4-0.40.20.4
Cu content in liver0.30.30.60.40.8-0.20.6-0.70.30.40.6-0.4-0.7
Fe content in liver1.11.41.81.11.3-1.11.2-1.31.01.21.2-1.0-1.2
K content in liver0.50.50.8-0.80.20.9-0.9-0.1-0.5-0.8-0.60.80.7
Mg content in liver0.40.41.30.21.1-0.10.4-1.10.10.50.5-0.5-0.5
Mn content in liver2.93.24.01.81.7-1.81.8-1.72.01.81.7-1.8-1.8
Na content in liver0.60.61.0-0.8-0.61.0-0.90.6-1.0-0.8-0.70.90.7
Rb content in liver0.20.30.5-0.70.30.7-0.5-0.2-0.6-0.5-0.60.30.7
Se content in liver2.22.63.11.61.5-1.61.7-1.51.41.71.7-1.7-1.6
Sr content in liver0.10.10.50.30.00.1-0.4-0.10.30.3-0.20.70.1
Zn content in liver0.10.10.20.10.30.00.3-0.3-0.40.30.4-0.3-0.4
Bone: minimum diameter1.01.92.91.41.6-1.21.1-1.61.71.51.2-1.1-1.1
Time in familiar zone, hab. session 10.20.21.0-0.11.00.10.3-0.9-0.1-0.10.1-0.20.1
Time in novel zone, hab. session 12.02.05.6-1.1-2.40.9-1.32.3-1.0-1.3-1.21.11.0
Total zone transitions, hab. session 11.01.42.31.11.5-1.01.1-1.51.01.21.1-1.0-0.9
Total locomotion distance, hab. session 10.71.01.61.01.3-0.81.1-1.20.81.01.0-0.8-0.8
Locomotion velocity, hab. session 11.31.92.91.41.7-1.11.4-1.71.21.51.4-1.0-1.2
Time in familiar zone, hab. session 21.31.42.2-1.5-0.91.2-0.91.0-1.3-1.4-1.10.81.3
Time in novel zone, hab. session 20.30.30.70.6-0.2-0.70.30.10.60.40.6-0.4-0.8
Total zone transitions, hab. session 20.00.00.1-0.10.10.20.0-0.1-0.1-0.10.10.30.1
Total locomotion distance, hab. session 20.10.10.40.40.0-0.40.4-0.10.40.40.6-0.3-0.4
Locomotion velocity, hab. session 20.10.10.30.30.1-0.30.3-0.20.30.30.6-0.2-0.3
Novel to familiar place preference ratio0.30.30.60.6-0.1-0.80.60.1-0.30.70.6-0.7-0.8
Novelty place preference0.30.40.60.6-0.3-0.80.60.2-0.40.70.6-0.8-0.8
Time in novel zone, NPP test0.50.61.10.7-0.3-1.10.80.2-0.20.80.8-1.0-1.1
Total zone transitions, NPP test0.81.12.51.01.6-0.80.8-1.51.00.91.0-0.6-0.8
Total locomotion distance, NPP test1.82.43.51.61.5-1.51.6-1.51.31.61.9-1.4-1.8
Locomotion velocity, NPP test1.41.92.81.41.7-1.11.2-1.71.21.41.5-1.1-1.4
Intraocular pressure6.18.811.23.22.4-3.33.0-2.52.93.13.0-3.1-3.1
Delta distance traveled before/after self-admin1.61.72.5-1.2-1.21.1-1.51.2-1.2-1.2-1.61.21.6
Delta ambulatory time before/after self-admin1.41.72.1-1.4-1.31.2-1.41.3-1.2-1.4-1.51.21.4
Parametrial fat weight0.00.10.1-0.30.20.3-0.2-0.2-0.3-0.3-0.40.20.2
Pavlov. Cond. lever latency0.20.30.90.50.3-0.70.4-0.31.00.20.5-0.5-0.7
Pavlov. Cond. magazine entry latency1.82.22.7-1.4-1.61.5-1.61.6-1.2-1.6-1.41.71.4
Pavlov. Cond. change in total contacts0.20.20.5-0.5-0.20.6-0.60.2-0.3-0.5-0.60.70.6
Pavlov. Cond. index score1.11.41.8-1.2-1.21.3-1.21.2-1.3-1.1-1.11.31.1
Pavlov. Cond. latency score1.11.41.9-1.1-1.21.2-1.11.2-1.4-1.0-1.01.21.1
Pavlov. Cond. lever contacts0.00.10.2-0.10.30.20.1-0.3-0.50.2-0.10.00.2
Pavlov. Cond. magazine entry number4.05.16.12.22.3-2.32.5-2.32.02.32.2-2.4-2.1
Pavlov. Cond. intertrial magazine entries0.91.12.41.01.6-0.80.8-1.51.41.00.4-0.7-0.3
Pavlov. Cond. lever-magazine prob. diff.0.60.81.0-0.9-0.81.0-0.90.8-1.0-0.8-0.81.00.8
Pavlov. Cond. response bias1.41.82.3-1.4-1.01.5-1.51.0-1.3-1.3-1.41.51.4
Pavlov. Cond. lever latency0.30.41.80.0-1.30.00.21.2-0.40.1-0.00.2-0.2
Pavlov. Cond. magazine entry latency3.64.35.9-2.2-1.42.2-2.41.5-1.9-2.3-2.22.12.1
Pavlov. Cond. change in total contacts0.30.62.2-0.31.50.4-0.5-1.30.6-0.5-0.40.40.5
Pavlov. Cond. index score0.81.12.0-1.20.31.2-1.4-0.2-0.4-1.3-1.21.11.2
Pavlov. Cond. latency score1.11.52.6-1.40.21.4-1.60.0-0.7-1.5-1.41.21.4
Pavlov. Cond. lever contacts0.30.42.0-0.01.4-0.0-0.1-1.30.6-0.10.0-0.20.2
Pavlov. Cond. magazine entry number2.63.35.02.00.8-2.02.2-0.91.22.02.2-1.9-2.0
Pavlov. Cond. intertrial magazine entries0.20.40.60.7-0.2-0.80.80.10.30.70.7-0.5-0.7
Pavlov. Cond. lever-magazine prob. diff.1.01.32.3-1.30.21.3-1.5-0.1-0.5-1.4-1.31.11.3
Pavlov. Cond. response bias0.30.30.8-0.40.90.5-0.7-0.80.2-0.5-0.50.40.6
Time in closed arm before self-admin0.40.51.10.70.3-0.71.0-0.30.40.91.0-0.8-0.7
Time in closed arm after self-admin1.01.12.10.80.9-0.91.2-0.90.31.01.5-1.2-1.2
Time in open arm before self-admin2.42.73.5-1.6-1.21.7-1.71.3-1.6-1.8-1.81.91.6
Time in open arm after self-admin2.73.04.8-1.6-1.41.6-2.21.5-0.6-1.8-2.21.91.9
Bone: periosteal estimation0.10.20.5-0.20.70.5-0.5-0.60.2-0.1-0.30.60.4
Bone: periosteal perimeter0.10.20.5-0.30.70.4-0.5-0.60.2-0.2-0.30.50.2
Bone: post-yield work0.10.20.5-0.5-0.40.6-0.60.4-0.1-0.5-0.40.70.1
Progressive ratio test 1 active lever presses0.50.61.5-1.20.01.1-0.50.0-1.2-0.8-0.20.60.4
Progressive ratio test 1 breakpoint0.40.51.3-1.10.21.1-0.5-0.1-1.1-0.7-0.20.60.3
Progressive ratio test 1 inactive lever presses0.20.30.9-0.40.70.20.6-0.6-0.60.10.9-0.4-0.7
Progressive ratio test 2 active lever presses2.22.53.9-2.0-1.31.9-1.61.4-1.8-1.7-1.21.51.3
Progressive ratio test 2 breakpoint2.02.33.6-1.9-1.21.8-1.61.3-1.7-1.6-1.21.41.3
Progressive ratio test 2 inactive lever presses0.40.71.7-0.9-1.30.7-0.41.3-1.0-0.8-0.10.40.2
Incentive Sensitization - Responses2.84.05.7-1.9-2.41.8-2.12.4-1.5-2.1-1.81.91.9
Incentive Sensitization - Breakpoint2.83.75.6-1.9-2.41.7-2.02.3-1.4-2.0-1.71.81.8
Sum of active levers in priming session hrs 5-60.10.10.50.5-0.2-0.30.00.10.70.0-0.0-0.1-0.2
Progressive ratio0.20.40.8-0.3-0.90.4-0.70.90.2-0.5-0.70.40.7
Food seeking constrained by brief footshock0.70.81.6-0.8-0.40.7-1.00.50.7-1.3-1.01.11.2
Seeking ratio, punishment vs. effort0.10.10.7-0.10.80.1-0.1-0.70.3-0.3-0.00.30.2
Retroperitoneal fat weight0.94.07.0-2.1-2.31.8-1.92.3-2.6-1.7-1.91.41.6
Reaction time number correct1.32.44.91.02.2-1.41.5-2.11.11.31.5-1.8-1.1
Reaction time mean minus median0.00.00.00.10.2-0.10.2-0.20.10.00.2-0.1-0.0
Reaction time mean minus median AUC0.10.20.3-0.5-0.40.4-0.30.4-0.4-0.5-0.30.30.3
Reaction time num false alarms0.40.61.1-1.0-0.41.0-0.90.5-0.8-0.8-0.60.60.6
Reaction time num false alarms AUC0.60.91.8-1.3-0.51.3-1.00.6-1.1-1.1-0.70.80.8
Reaction time trials correct on left1.32.44.91.02.2-1.41.5-2.11.11.31.5-1.8-1.1
Reaction time trials on left1.52.95.61.12.4-1.61.6-2.31.21.41.6-2.0-1.2
Reaction time mean0.40.71.30.80.4-0.90.9-0.50.30.81.0-1.1-1.0
Reaction time mean AUC0.30.40.90.60.2-0.80.7-0.30.10.70.8-0.9-0.9
Median of all reaction times0.30.50.90.70.1-0.80.7-0.20.10.70.8-1.0-1.0
Reaction time omissions2.33.35.61.42.2-1.91.8-2.11.61.11.8-2.4-1.8
Reaction time false alarm rate2.02.83.9-1.7-1.72.0-1.81.7-1.6-1.6-1.51.71.4
Reaction time premature initiation rate3.14.38.1-1.9-2.81.5-1.82.8-1.6-2.3-1.91.81.9
Reaction time premature initiations0.40.71.4-0.9-1.00.4-0.61.0-0.7-1.2-0.70.40.9
Std. dev. reaction times0.30.50.70.60.6-0.70.8-0.60.40.50.8-0.9-0.8
Reaction time trials completed1.52.95.61.12.4-1.61.6-2.31.21.41.6-2.0-1.2
Reaction time trials AUC1.42.75.51.12.4-1.51.5-2.31.31.31.5-1.9-1.1
Run reversals in cocaine runway, females0.10.10.50.10.10.10.2-0.1-0.70.30.10.1-0.2
Run reversals in cocaine runway, males0.30.30.60.40.0-0.50.7-0.1-0.40.70.7-0.6-0.6
Latency to leave start box in cocaine runway0.40.41.40.41.2-0.10.5-1.10.40.60.5-0.4-0.3
Latency to leave start box in cocaine runway, F0.40.52.10.21.50.20.2-1.40.50.40.20.00.0
Latency to leave start box in cocaine runway, M0.10.10.20.5-0.2-0.40.40.10.10.40.3-0.5-0.3
Std. dev. time between licks in bursts1.72.32.9-1.6-1.51.7-1.31.5-1.5-1.5-1.41.61.3
Total sessions with >9 infusions0.30.41.7-1.0-0.40.7-0.40.4-1.3-0.6-0.20.10.1
Short access day 1 total inactive lever presses0.30.41.6-0.51.30.6-0.4-1.10.2-0.5-0.20.30.1
Short access day 10 total inactive lever presses0.92.24.01.41.9-1.31.3-1.82.01.21.2-1.3-0.9
Short access day 1 total infusions0.30.31.6-0.8-0.30.7-0.50.3-1.2-0.2-0.30.40.2
Short access day 10 total infusions0.30.41.1-0.81.10.40.2-0.9-0.7-0.30.4-0.4-0.4
Short access total infusions0.40.51.3-1.10.31.0-0.5-0.2-1.1-0.7-0.30.40.2
Short access day 1 locomotion0.20.20.7-0.40.5-0.10.3-0.4-0.80.10.4-0.5-0.4
Short access day 10 total locomotion3.15.811.41.83.4-1.82.2-3.31.22.52.2-2.5-2.1
Short access total locomotion1.51.83.90.52.0-0.91.4-1.90.11.11.4-1.6-1.4
One hour access (0.3 mA shock)0.50.51.3-0.9-0.90.8-0.50.9-1.2-0.6-0.20.50.3
Compulsive drug intake0.30.30.6-0.40.70.8-0.7-0.6-0.1-0.4-0.50.60.5
One hour access (shock baseline)0.10.20.4-0.5-0.60.2-0.10.6-0.6-0.3-0.00.10.1
Social response proportion5.96.78.12.82.7-2.72.5-2.72.42.82.3-2.5-2.4
Social responses1.62.12.51.61.4-1.51.5-1.51.41.61.3-1.5-1.1
Social time1.62.24.41.71.9-1.51.0-1.82.11.20.8-0.9-1.1
Soleus weight0.10.41.3-0.4-0.61.0-0.50.5-0.1-0.3-0.41.10.3
Bone: stiffness0.40.61.1-0.6-0.50.7-1.10.5-0.6-0.6-0.90.81.0
Tibialis anterior weight3.010.112.93.43.1-2.93.1-3.23.63.33.2-2.7-3.1
Time to tail flick, vehicle, before self-admin0.60.63.0-0.41.70.5-0.3-1.5-0.0-0.2-0.20.20.2
Time to tail flick, vehicle, after self-admin0.40.51.0-0.8-0.20.9-0.80.2-0.9-0.6-0.60.81.0
Time to tail flick, test, before self-admin0.30.30.80.10.9-0.20.7-0.8-0.30.30.4-0.6-0.1
Time to tail flick, test, after self-admin0.70.71.81.30.9-0.80.5-0.91.01.30.3-0.4-0.2
Delta time to tail flick, vehicle, before/after SA0.30.31.30.1-1.10.1-0.11.0-0.3-0.10.00.30.2
Delta time to tail flick, test, before/after SA0.60.62.51.20.5-0.80.1-0.51.60.90.2-0.1-0.2
Tibia length0.31.01.5-1.0-0.70.9-1.10.7-0.9-1.0-1.10.91.2
Ambulatory time before self-admin0.30.50.9-0.7-0.00.9-0.90.1-0.8-0.5-0.80.90.5
Ambulatory time after self-admin1.51.83.4-1.4-0.31.4-1.80.4-1.2-1.1-1.81.51.4
Bone: tissue strength0.10.10.2-0.0-0.20.1-0.40.2-0.1-0.2-0.40.30.2
Total heroin consumption0.40.40.90.81.0-0.70.5-0.90.90.50.3-0.4-0.2
Bone: trabecular number0.00.00.10.10.20.1-0.1-0.20.4-0.0-0.10.10.0
Bone: trabecular spacing0.10.20.40.30.3-0.40.4-0.30.20.50.6-0.6-0.4
Bone: trabecular thickness2.32.93.71.91.6-1.61.7-1.71.91.81.6-1.3-1.7
Bone: trabecular tissue density0.20.30.70.70.1-0.70.5-0.20.10.60.7-0.6-0.8
Water consumed over 24 hours2.33.04.7-1.7-1.61.5-2.11.7-1.5-1.7-2.01.42.2
Number of responses in last shaping day0.20.21.8-0.50.10.2-0.1-0.1-1.40.00.2-0.1-0.2