Hub : Genes

Hmgcl

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Hmgcl 0.11 0.07 3.8e-06 0.07 0.07 0.06 0.07 7.6e-07 2.7e-07 3.8e-06 9.2e-07
2 Adipose gene expression Hmgcl 0.2 0.1 0.0e+00 0.16 0.16 0.16 0.16 5.8e-17 5.8e-18 9.9e-18 3.0e-17
3 IL mRNA stability Hmgcl 0.14 0.1 4.1e-03 0.13 0.07 0.04 0.1 4.4e-04 1.1e-02 3.3e-02 2.4e-03
4 Brain gene expression Hmgcl 0.06 0.04 1.1e-07 0.08 0.06 0.07 0.07 1.5e-07 1.3e-06 2.4e-07 4.7e-07
5 PL mRNA stability Hmgcl 0.03 0.02 2.3e-03 0.03 0.03 0.02 0.02 1.7e-04 8.5e-04 9.1e-04 1.1e-03
6 NAcc mRNA stability Hmgcl 0.04 0.03 1.3e-04 0.02 0.02 0.02 0.03 1.1e-03 1.0e-03 1.0e-03 4.6e-04
7 BLA mRNA stability Hmgcl 0.07 0.05 4.3e-04 0.06 0.04 0.04 0.05 4.6e-04 3.7e-03 4.7e-03 1.5e-03
8 PL gene expression Hmgcl 0.11 0.06 6.1e-10 0.1 0.08 0.09 0.1 1.1e-10 5.6e-09 9.1e-10 1.5e-10
9 IL gene expression Hmgcl 0.28 0.12 1.5e-07 0.32 0.19 0.32 0.33 2.1e-08 2.4e-05 2.5e-08 1.2e-08
10 Liver gene expression Hmgcl 0.03 0.02 2.2e-04 0.02 0.02 0.01 0.02 1.3e-03 2.6e-03 2.4e-02 3.5e-03
11 Liver mRNA stability Hmgcl 0.04 0.03 1.0e-04 0.03 0.02 0.02 0.02 4.4e-04 1.4e-03 2.4e-03 1.6e-03
12 Adipose mRNA stability Hmgcl 0.11 0.06 4.0e-13 0.1 0.1 0.08 0.1 5.8e-11 1.1e-10 8.3e-09 8.7e-11
13 OFC gene expression Hmgcl 0.21 0.12 1.2e-04 0.12 0.19 0.17 0.16 7.5e-04 3.1e-05 7.1e-05 1.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.11.83.40.4-1.0-1.61.0-1.21.0-0.70.6-1.21.8-1.8-1.8-1.8
Area under the delay curve1.11.21.80.8-1.2-1.11.1-0.91.1-1.01.0-1.01.2-1.2-1.1-1.3
BMI with tail2.89.211.63.4-3.2-2.93.3-3.33.3-3.43.2-3.32.4-2.4-2.3-2.6
BMI without tail2.95.97.22.4-2.7-2.22.6-2.62.6-2.22.1-2.72.4-2.4-2.4-2.3
Body weight4.418.228.64.5-4.3-5.44.4-4.94.5-4.44.3-4.33.5-3.5-3.3-3.9
Weight adjusted by age0.00.00.1-0.10.10.30.20.30.1-0.10.1-0.1-0.10.1-0.10.0
Bone surface1.52.64.80.9-1.4-1.91.3-1.41.3-0.90.9-1.42.2-2.2-2.2-1.9
Bone volume1.22.14.30.6-1.2-1.61.1-1.31.1-0.80.8-1.32.1-2.1-2.0-1.8
Breakpoint value in progressive ratio session2.02.24.3-1.72.10.4-1.41.0-1.41.4-1.41.3-1.71.71.81.2
Number of licking bursts0.70.82.2-0.30.90.5-0.70.7-0.60.4-0.40.5-1.41.41.51.2
Context. condit. distance diff. score0.60.71.60.8-0.6-1.21.1-1.30.9-0.80.8-1.00.3-0.3-0.3-0.8
Locomotion velocity, session 10.60.71.20.7-0.8-0.90.5-0.70.5-0.90.9-0.71.0-1.0-1.1-1.0
Locomotion distance, session 10.30.40.70.1-0.6-0.20.3-0.50.4-0.70.7-0.60.8-0.8-0.9-0.8
Locomotion velocity, session 21.01.23.1-1.40.91.8-1.41.5-1.30.9-0.91.0-0.40.40.00.6
Locomotion distance, session 20.60.81.70.7-0.9-0.70.3-0.70.6-1.11.1-0.91.0-1.0-1.3-1.3
Locomotion velocity, session 31.41.73.4-0.81.40.7-1.41.1-1.21.0-1.01.1-1.61.61.81.6
Locomotion distance, session 30.80.92.31.2-0.7-1.00.6-1.10.9-1.51.5-1.10.1-0.10.2-0.7
Stereotopy head waving bouts, day 31.11.32.6-1.51.00.9-1.41.3-1.51.3-1.31.60.0-0.0-0.10.7
Stereotopy head waving duration, day 31.72.03.2-1.71.31.2-1.61.7-1.81.8-1.71.8-0.50.50.21.2
Locomotion velocity, session 70.80.92.21.5-1.0-0.90.8-1.11.0-1.31.3-0.90.2-0.2-0.1-0.4
Locomotion distance, session 70.10.10.30.4-0.0-0.10.2-0.20.2-0.30.3-0.3-0.30.30.5-0.1
Stereotopy head waving bouts, day 70.10.10.60.3-0.4-0.40.2-0.20.2-0.30.3-0.00.3-0.3-0.8-0.3
Stereotopy head waving duration, day 70.20.31.00.1-0.4-0.80.3-0.30.2-0.40.4-0.30.5-0.5-1.0-0.8
Locomotion velocity, session 80.40.51.00.4-0.7-0.80.3-0.70.4-0.70.7-0.50.9-0.9-1.0-0.8
Locomotion distance, session 81.42.03.31.6-1.3-1.71.5-1.81.5-1.51.5-1.70.8-0.8-0.8-1.3
Degree of sensitization distance1.51.52.9-1.51.11.3-1.01.4-1.31.7-1.71.3-0.60.60.40.8
Degree of sensitization stereotypy1.51.62.21.4-1.5-1.31.3-1.31.4-1.41.4-1.30.8-0.8-1.3-1.2
Conditioned locomotion0.80.92.2-1.10.21.5-1.31.4-1.10.8-0.81.10.6-0.6-0.80.3
Cocaine response after cond. corrected2.42.75.6-2.11.62.4-2.02.0-1.91.7-1.71.7-0.90.90.51.1
Cocaine response after cond. not corrected3.13.46.5-2.01.82.6-2.22.2-2.01.7-1.71.9-1.31.31.11.6
Cocaine response before conditioning0.30.30.90.9-0.5-0.80.6-0.70.6-0.60.7-0.50.1-0.10.20.0
Saline control response2.63.55.1-1.62.11.0-1.61.5-1.71.9-1.91.9-2.32.32.02.0
Bone: connectivity density0.60.92.20.2-0.8-0.90.8-0.80.8-0.50.5-1.01.2-1.2-1.5-1.3
Bone: cortical apparent density0.50.71.7-0.60.90.4-0.70.6-0.60.7-0.70.4-1.31.31.10.8
Bone: cortical area1.52.35.81.6-1.4-2.41.4-2.01.4-1.31.2-1.31.5-1.5-1.1-1.1
Bone: cortical porosity0.90.92.2-0.60.81.5-0.81.1-0.90.8-0.70.8-1.01.00.91.3
Bone: cortical porosity0.91.02.5-0.90.81.6-1.01.3-1.01.0-1.00.8-0.80.80.71.3
Bone: cortical thickness0.40.63.40.9-0.4-1.90.5-1.40.6-0.50.5-0.60.2-0.20.1-0.0
Bone: cortical thickness0.81.01.8-0.51.0-0.8-0.70.1-0.71.0-1.00.7-1.31.31.31.3
Bone: cortical tissue density0.70.92.0-0.71.00.6-0.80.8-0.70.8-0.80.6-1.41.41.20.9
Condit. Reinf. active minus inactive responses0.40.40.8-0.70.80.4-0.70.6-0.70.5-0.50.5-0.50.50.90.3
Condit. Reinf. active-inactive response ratio0.10.10.5-0.70.50.3-0.30.3-0.30.5-0.50.1-0.10.10.4-0.1
Condit. Reinf. active responses0.10.10.3-0.40.30.5-0.40.3-0.30.1-0.10.00.0-0.00.2-0.1
Condit. Reinf. inactive responses0.10.10.30.3-0.40.20.3-0.10.3-0.30.3-0.50.2-0.2-0.5-0.3
Incentive salience index mean0.20.30.6-0.40.60.6-0.70.5-0.60.4-0.40.4-0.50.50.80.4
Condit. Reinf. lever presses0.00.00.20.3-0.10.5-0.20.1-0.1-0.20.2-0.10.1-0.10.10.3
Condit. Reinf. active minus inactive responses1.82.32.81.6-1.6-1.61.4-1.61.4-1.51.5-1.41.7-1.7-1.4-1.1
Condit. Reinf. active-inactive response ratio0.00.00.10.2-0.20.00.0-0.00.00.1-0.00.10.1-0.1-0.10.4
Condit. Reinf. active responses3.95.48.52.4-2.3-2.92.3-2.62.3-2.32.3-2.12.2-2.2-2.0-1.9
Condit. Reinf. inactive responses4.85.99.82.3-2.3-3.12.2-2.62.3-2.32.3-2.22.4-2.4-2.2-2.5
Condit. Reinf. lever presses1.21.63.30.9-1.1-1.81.0-1.31.1-1.11.1-1.21.6-1.6-1.2-1.4
Condit. Reinf. lever reinforcers received3.24.58.02.2-2.1-2.82.0-2.42.1-2.02.0-1.92.1-2.1-1.9-1.9
Conditioned reinforcement - actives3.33.35.12.2-2.2-1.12.2-1.72.1-2.12.1-2.01.3-1.3-1.5-1.4
Conditioned reinforcement - inactives1.21.42.51.6-1.4-1.21.3-1.31.2-1.21.2-1.10.9-0.9-0.8-0.8
Conditioned locomotion3.94.76.52.3-2.4-1.72.3-2.22.4-2.52.5-2.31.7-1.7-1.8-2.0
Patch foraging indifference point 0 sec0.00.00.1-0.20.3-0.3-0.2-0.1-0.00.3-0.30.1-0.10.10.20.0
Patch foraging indifference point AUC0.80.91.91.4-0.9-1.01.3-0.91.1-1.11.1-1.30.1-0.10.2-0.6
Delay disc. indifference point, 0s delay0.80.82.50.3-0.5-1.60.8-1.00.7-0.50.5-0.80.9-0.9-0.9-1.4
Delay disc. indifference point, 16s delay1.11.11.90.7-1.2-0.81.1-0.90.9-0.80.8-0.91.4-1.4-1.3-1.2
Delay disc. indifference point, 2s delay0.40.52.10.8-0.4-1.50.7-0.80.7-0.70.7-0.7-0.10.10.2-0.6
Delay disc. indifference point, 24s delay0.20.20.70.0-0.50.10.00.30.00.00.0-0.10.8-0.8-0.8-0.3
Delay disc. indifference point, 4s delay0.60.71.60.5-0.7-1.20.7-0.90.7-0.60.6-0.70.8-0.8-0.8-1.3
Delay disc. indifference point, 8s delay1.71.83.10.8-1.4-1.11.2-1.11.1-1.11.1-1.21.8-1.8-1.7-1.6
Indifference point function ln k1.11.63.6-1.40.01.3-1.31.1-1.10.9-0.91.01.8-1.8-1.9-0.3
Indifference point function log k1.11.63.6-1.40.01.3-1.31.1-1.10.9-0.91.01.8-1.8-1.9-0.3
Patch foraging total patch changes 0 sec0.00.10.1-0.30.4-0.2-0.2-0.0-0.10.4-0.40.2-0.10.10.10.0
Patch foraging total patch changes 12 sec0.50.61.20.70.0-0.80.8-0.70.8-0.60.6-0.8-1.01.01.1-0.3
Patch foraging total patch changes 18 sec0.20.20.80.20.3-0.60.3-0.20.10.2-0.2-0.3-0.70.70.90.0
Patch foraging total patch changes 24 sec0.30.41.60.40.1-1.30.8-0.70.5-0.40.4-0.5-0.50.50.6-0.4
Patch foraging total patch changes 6 sec0.30.41.50.50.3-0.70.3-0.40.4-0.20.2-0.3-1.11.11.20.2
Patch foraging time to switch 0 sec1.62.57.0-0.41.50.9-0.80.9-0.81.0-0.90.9-2.62.62.61.9
Patch foraging water rate 0 sec0.20.31.0-0.90.00.4-0.30.3-0.30.4-0.40.30.9-0.9-1.0-0.3
Patch foraging water rate 12 sec0.20.41.5-0.1-0.5-0.40.1-0.40.1-0.20.2-0.31.1-1.1-1.2-0.5
Patch foraging water rate 18 sec1.72.35.30.7-1.4-1.30.9-1.31.1-1.21.2-1.32.1-2.1-2.3-2.0
Patch foraging water rate 24 sec0.30.41.1-1.00.20.9-0.60.7-0.60.5-0.40.40.5-0.5-0.9-0.2
Patch foraging water rate 6 sec0.30.41.2-1.10.40.6-0.60.7-0.80.6-0.60.60.5-0.5-0.8-0.1
Seeking ratio, delayed vs. immediate footshock0.80.92.70.8-0.8-1.61.0-1.11.0-0.80.7-1.00.7-0.7-0.6-1.0
Distance traveled before self-admin1.51.64.21.2-1.0-2.11.2-1.71.3-0.91.0-1.31.0-1.0-0.9-1.3
Distance traveled after self-admin2.32.53.81.9-1.8-1.81.7-1.91.6-1.51.6-1.51.3-1.3-1.4-1.1
Extensor digitorum longus weight0.31.33.21.2-1.0-1.81.1-1.51.1-1.10.9-1.01.0-1.0-0.9-1.1
Bone: elastic displacement0.30.40.8-0.70.50.6-0.90.9-0.70.4-0.30.7-0.40.40.20.3
Bone: elastic work0.10.10.4-0.40.40.0-0.60.4-0.50.2-0.20.5-0.20.20.1-0.0
Bone: endosteal estimation3.78.112.52.3-3.0-2.42.6-2.52.6-2.52.5-2.63.5-3.5-3.4-3.1
Bone: endosteal perimeter3.26.611.42.0-2.7-2.02.4-2.32.3-2.32.2-2.03.4-3.4-3.1-2.8
Epididymis fat weight1.22.84.11.5-1.8-1.31.7-1.61.6-1.61.6-1.72.0-2.0-1.7-1.5
Delta time in closed arm before/after self-admin0.50.51.20.8-0.80.10.8-0.50.8-1.11.0-0.90.3-0.3-0.3-0.6
Delta time in open arm before/after self-admin1.21.22.0-0.61.00.1-0.90.8-1.01.2-1.31.2-1.21.21.41.3
Diff in mean of infusions in LGA sessions0.40.41.0-0.80.71.0-0.30.6-0.40.7-0.60.3-0.70.70.80.6
Delay discount exponential model param1.11.21.6-0.91.21.1-1.00.9-1.01.0-1.00.9-1.21.21.11.3
Extinction: sum of active levers before priming0.40.42.0-0.70.6-1.4-0.6-0.0-0.60.4-0.30.30.3-0.3-0.2-0.7
Active lever presses in extinction session 60.20.20.4-0.70.50.5-0.40.2-0.40.4-0.40.1-0.30.30.30.1
Bone: final force1.52.53.71.8-1.6-1.91.7-1.91.7-1.51.5-1.71.5-1.5-0.9-1.0
Bone: final moment2.23.64.52.0-1.9-2.11.9-2.12.0-1.81.8-2.01.9-1.9-1.4-1.4
Food consumed during 24 hour testing period0.10.10.6-0.70.40.2-0.40.4-0.50.4-0.40.40.1-0.1-0.1-0.2
Glucose0.40.73.10.10.6-0.20.0-0.20.1-0.30.3-0.0-1.81.81.30.5
Heart weight0.30.40.9-0.50.9-0.6-0.4-0.2-0.30.7-0.70.6-0.50.50.90.5
Delay discount hyperbolic model param1.11.21.7-1.01.21.2-1.11.0-1.11.0-1.01.0-1.11.11.01.3
Intermittent access intake day 1-15 change7.07.010.23.0-3.2-2.12.7-2.32.7-2.82.7-2.62.7-2.7-2.7-2.1
Intermittent access intake escalation5.65.58.22.6-2.9-1.62.3-1.92.3-2.42.4-2.22.5-2.5-2.6-1.9
Intermittent access intake escalation 23.83.76.32.1-2.5-0.81.7-1.41.8-2.01.9-1.72.4-2.4-2.4-1.4
Intermitt. access day 1 inactive lever presses2.93.15.32.1-1.9-2.31.6-1.81.5-1.91.9-1.51.5-1.5-1.4-1.6
Intermitt. access day 15 inactive lever presses1.92.04.02.0-1.9-1.01.4-1.21.4-1.61.6-1.31.2-1.2-1.3-0.9
Intermitt. access escalation Index0.30.21.40.3-0.0-1.20.3-0.70.3-0.40.5-0.3-0.10.10.1-0.5
Intermittent access day 1 total infusions1.92.25.32.3-1.6-0.71.9-1.61.9-1.91.9-1.5-0.10.10.2-0.1
Intermittent access day 15 total infusions6.37.014.93.9-3.3-1.93.1-2.63.1-3.33.2-2.71.5-1.5-1.5-1.2
Intermittent access terminal intake (last 3 days)4.85.211.03.3-2.9-1.32.7-2.12.7-2.82.7-2.31.4-1.4-1.4-1.0
Intermittent access total infusions4.55.011.23.3-2.9-1.12.8-2.22.8-2.82.7-2.31.0-1.0-1.0-0.7
Intermittent access day 1 locomotion1.21.23.21.8-1.3-0.41.4-1.21.4-1.41.4-1.1-0.10.10.1-0.0
Intermittent access day 15 total locomotion2.42.65.22.0-2.30.21.8-1.01.8-2.01.9-1.71.3-1.3-1.5-0.9
Intermittent access total locomotion1.92.25.02.2-1.9-0.71.9-1.41.9-1.91.8-1.60.5-0.5-0.6-0.4
Intermittent access standard deviation7.98.417.74.2-3.5-2.83.2-3.03.2-3.33.3-2.81.8-1.8-1.7-1.6
Left kidney weight3.59.820.13.8-2.8-4.53.3-3.73.5-3.33.4-3.42.2-2.2-1.0-2.4
Right kidney weight0.61.65.91.9-0.8-2.41.3-1.51.4-1.21.2-1.10.1-0.10.8-0.2
Cocaine induced anxiety1.51.72.6-1.21.60.1-1.50.8-1.41.3-1.31.6-1.51.51.31.0
Post-drug Anxiety3.23.65.4-2.32.30.7-2.21.5-2.22.3-2.32.2-1.51.51.41.3
Baseline Anxiety0.30.31.2-0.5-0.3-0.10.2-0.10.10.2-0.2-0.31.0-1.0-1.1-0.8
Tail length0.41.33.00.6-1.0-1.71.1-1.51.1-0.50.6-1.01.3-1.3-1.2-1.1
Length with tail0.72.79.21.5-1.3-3.01.8-2.31.7-1.41.4-1.51.0-1.0-0.9-1.3
Length without tail0.91.96.51.7-0.9-2.61.3-1.81.4-1.61.6-1.10.3-0.3-0.2-0.8
Times rat made contact with spout1.71.92.5-1.51.61.6-1.41.6-1.51.2-1.21.2-1.41.41.21.2
Lifetime Intake3.33.78.72.9-2.5-0.62.5-1.92.5-2.42.3-2.10.6-0.6-0.5-0.4
Liver weight, left3.45.58.82.6-2.3-3.02.6-2.72.5-2.62.6-2.51.4-1.4-1.6-1.9
Liver weight, right1.01.75.42.0-0.9-2.31.1-1.71.3-1.61.5-1.0-0.00.00.6-0.4
Locomotor activity3.96.114.33.3-2.3-3.82.5-3.02.6-2.82.7-2.41.0-1.0-0.8-1.9
Locomotor testing distance2.64.36.52.4-2.1-2.51.9-2.22.0-2.42.3-2.01.6-1.6-1.6-2.0
Locomotor testing rearing3.45.36.32.4-2.3-2.32.4-2.22.3-2.52.5-2.22.1-2.1-2.0-2.3
Locomotion in novel chamber1.31.63.31.7-1.3-1.81.3-1.51.3-1.41.3-1.00.9-0.9-0.7-0.9
Locomotion in novel chamber post-restriction1.92.34.32.1-1.8-0.91.8-1.71.9-1.81.8-1.70.8-0.8-0.9-0.5
Fecal boli incidents, locomotor time 11.31.53.71.8-0.8-1.91.4-1.51.4-1.31.2-1.0-0.50.50.7-0.4
Change in fecal boli incidents, locomotor task1.11.12.3-1.30.51.5-1.21.3-1.21.1-1.21.00.7-0.7-0.70.5
Time >=10cm from walls, locomotor time 10.60.60.90.5-0.8-0.50.8-1.00.9-0.80.8-0.80.7-0.7-0.9-0.7
Bouts of movement, locomotor time 10.30.31.11.0-0.90.30.5-0.20.5-0.70.7-0.30.1-0.1-0.10.5
Total resting periods, locomotor time 10.30.31.21.1-0.80.30.5-0.20.6-0.70.7-0.3-0.00.00.10.6
Rest time, locomotor task time 11.01.13.50.10.51.2-0.40.6-0.30.3-0.40.5-1.81.81.91.5
Distance moved, locomotor task time 10.80.92.7-0.3-0.2-1.20.4-0.60.3-0.20.3-0.51.4-1.4-1.6-1.5
Vertical activity count, locomotor time 10.50.52.70.2-0.3-1.60.4-0.60.3-0.00.1-0.30.8-0.8-0.9-0.8
Time >=10cm from walls, locomotor time 20.10.10.3-0.10.30.1-0.1-0.0-0.10.2-0.30.2-0.60.60.50.6
Bouts of movement, locomotor time 20.80.91.8-0.40.71.0-0.81.0-0.80.6-0.70.8-1.21.21.11.4
Total resting periods, locomotor time 21.21.22.7-0.50.81.3-0.81.2-0.90.8-0.80.9-1.41.41.41.6
Rest time, locomotor task time 21.72.04.2-0.71.11.5-0.81.1-0.81.0-1.11.1-2.12.12.01.8
Distance moved, locomotor task time 21.11.32.40.5-0.8-1.21.0-1.21.0-1.11.1-1.21.2-1.2-1.2-1.5
Vertical activity count, locomotor time 20.50.63.30.4-0.3-1.80.4-1.00.5-0.50.4-0.50.5-0.5-0.6-1.1
Light reinforcement 10.10.21.30.20.1-1.10.5-0.70.3-0.40.4-0.3-0.10.10.2-0.1
Light reinforcement 20.50.71.70.6-0.7-0.70.7-0.70.5-1.31.3-0.40.9-0.9-0.9-0.7
Bone: marrow area3.88.312.92.3-3.1-2.52.7-2.52.6-2.62.5-2.63.6-3.6-3.5-3.2
Bone: maximum diameter2.74.98.02.0-2.1-2.82.2-2.52.1-1.91.8-1.92.5-2.5-2.1-2.2
Bone: maximum force2.64.45.92.0-2.1-2.42.0-2.32.0-1.91.9-2.02.4-2.4-1.8-1.8
Bone: maximum moment3.56.08.32.3-2.5-2.62.3-2.62.3-2.32.2-2.32.9-2.9-2.4-2.2
Mean time between licks in bursts0.40.61.60.4-0.7-0.70.4-0.50.4-0.70.7-0.41.3-1.3-1.0-0.9
Mean num. licks in bursts0.10.20.5-0.70.20.5-0.20.4-0.30.4-0.40.40.3-0.3-0.5-0.3
Cd content in liver2.12.33.81.7-1.5-1.21.9-1.61.9-1.81.7-1.81.0-1.0-0.8-1.4
Co content in liver0.00.00.2-0.1-0.00.4-0.30.20.10.2-0.20.40.1-0.1-0.00.2
Cu content in liver1.72.12.6-1.21.41.6-1.61.5-1.41.2-1.21.4-1.51.51.41.6
Fe content in liver0.20.20.6-0.10.4-0.60.6-0.80.50.3-0.4-0.1-0.60.60.50.1
K content in liver0.00.00.10.2-0.10.10.10.0-0.0-0.20.40.00.1-0.1-0.20.1
Mg content in liver0.00.00.20.10.1-0.20.20.1-0.0-0.30.5-0.1-0.20.20.10.0
Mn content in liver1.31.43.01.3-1.0-1.71.6-1.71.4-1.01.0-1.10.8-0.8-0.4-0.8
Na content in liver1.51.63.51.5-1.2-1.91.6-1.41.5-1.21.3-1.40.5-0.5-0.6-0.9
Rb content in liver0.30.30.6-0.60.8-0.1-0.20.2-0.40.7-0.50.6-0.70.70.70.6
Se content in liver0.60.81.8-0.71.00.7-0.40.2-0.40.7-0.80.5-1.31.31.31.0
Sr content in liver4.74.38.11.6-2.2-1.41.7-1.61.9-1.92.0-2.02.8-2.8-2.3-2.4
Zn content in liver0.20.20.50.7-0.1-0.40.3-0.30.4-0.60.7-0.2-0.40.40.40.0
Bone: minimum diameter0.91.73.71.4-1.3-1.91.2-1.51.2-1.01.0-1.21.4-1.4-1.0-1.0
Time in familiar zone, hab. session 10.50.50.9-0.81.00.5-0.70.7-0.60.7-0.70.6-0.80.80.90.4
Time in novel zone, hab. session 10.10.10.30.3-0.4-0.10.1-0.10.1-0.00.0-0.10.3-0.3-0.50.0
Total zone transitions, hab. session 10.10.10.30.30.1-0.30.2-0.40.2-0.10.1-0.2-0.50.50.60.1
Total locomotion distance, hab. session 10.10.10.30.4-0.1-0.10.4-0.30.3-0.00.0-0.1-0.60.60.40.3
Locomotion velocity, hab. session 10.20.20.90.10.20.20.2-0.00.10.2-0.20.1-1.01.00.80.5
Time in familiar zone, hab. session 22.22.33.3-1.51.71.0-1.81.6-1.71.6-1.61.5-1.51.51.41.0
Time in novel zone, hab. session 20.00.00.2-0.40.20.00.00.0-0.20.3-0.30.30.2-0.2-0.20.2
Total zone transitions, hab. session 21.41.82.90.9-1.4-0.50.9-1.11.1-1.51.5-1.31.6-1.6-1.7-1.7
Total locomotion distance, hab. session 20.10.10.20.3-0.40.40.1-0.10.2-0.50.5-0.30.3-0.3-0.4-0.4
Locomotion velocity, hab. session 20.30.50.90.8-0.8-0.00.5-0.60.7-0.90.9-0.80.5-0.5-0.6-0.7
Novel to familiar place preference ratio0.20.20.40.7-0.4-0.30.6-0.50.6-0.30.3-0.4-0.40.40.60.1
Novelty place preference0.30.30.70.8-0.4-0.50.7-0.60.7-0.40.4-0.4-0.50.50.70.2
Time in novel zone, NPP test0.30.31.10.50.0-0.30.3-0.20.30.0-0.0-0.0-0.90.91.00.5
Total zone transitions, NPP test0.30.41.00.8-0.7-0.40.5-0.70.6-1.01.0-0.70.4-0.4-0.6-0.6
Total locomotion distance, NPP test0.00.00.20.00.00.30.1-0.00.0-0.00.00.1-0.40.40.20.1
Locomotion velocity, NPP test0.10.10.20.4-0.40.00.3-0.30.3-0.40.4-0.2-0.10.1-0.2-0.2
Intraocular pressure0.40.61.30.6-0.9-0.51.2-1.01.0-0.50.3-1.00.6-0.6-1.0-0.6
Delta distance traveled before/after self-admin0.10.10.30.6-0.50.40.20.10.1-0.50.5-0.00.1-0.1-0.30.3
Delta ambulatory time before/after self-admin0.20.20.60.8-0.60.80.20.10.2-0.60.60.0-0.20.20.10.7
Parametrial fat weight0.10.10.50.4-0.30.30.3-0.10.3-0.10.1-0.2-0.40.40.30.7
Pavlov. Cond. lever latency0.50.61.7-0.40.8-0.5-0.40.2-0.40.7-0.70.6-1.31.31.00.7
Pavlov. Cond. magazine entry latency0.10.10.20.3-0.40.10.5-0.30.4-0.30.3-0.50.5-0.5-0.1-0.3
Pavlov. Cond. change in total contacts0.10.10.3-0.0-0.20.50.30.00.2-0.0-0.0-0.20.5-0.5-0.2-0.4
Pavlov. Cond. index score0.40.50.90.5-0.80.10.6-0.50.6-0.70.7-0.80.9-0.9-0.7-0.8
Pavlov. Cond. latency score0.30.40.90.4-0.70.40.5-0.30.5-0.70.7-0.60.9-0.9-0.7-0.7
Pavlov. Cond. lever contacts0.20.20.8-0.1-0.30.7-0.00.1-0.1-0.20.2-0.20.9-0.9-0.7-0.5
Pavlov. Cond. magazine entry number0.70.91.4-1.21.00.8-1.21.0-1.11.0-1.01.2-0.80.80.40.8
Pavlov. Cond. intertrial magazine entries7.18.69.8-3.13.13.0-3.03.0-3.13.0-3.03.0-2.62.62.42.9
Pavlov. Cond. lever-magazine prob. diff.0.20.30.70.3-0.50.20.4-0.20.3-0.40.4-0.50.8-0.8-0.6-0.6
Pavlov. Cond. response bias0.20.30.50.6-0.6-0.20.6-0.40.5-0.40.4-0.70.6-0.6-0.2-0.4
Pavlov. Cond. lever latency0.81.02.1-0.60.81.3-0.70.8-0.80.8-0.81.1-1.41.40.91.2
Pavlov. Cond. magazine entry latency0.20.30.9-0.60.1-0.40.4-0.20.20.2-0.2-0.40.8-0.8-0.5-1.0
Pavlov. Cond. change in total contacts1.62.34.01.0-1.3-2.01.2-1.51.3-1.31.3-1.51.8-1.8-1.5-1.8
Pavlov. Cond. index score0.30.41.2-0.1-0.2-0.90.3-0.50.3-0.20.2-0.51.1-1.1-0.7-1.0
Pavlov. Cond. latency score0.30.31.1-0.2-0.2-0.70.2-0.40.2-0.20.1-0.51.0-1.0-0.7-0.9
Pavlov. Cond. lever contacts0.91.32.90.7-0.8-1.70.9-1.10.9-1.01.0-1.21.4-1.4-0.9-1.3
Pavlov. Cond. magazine entry number0.40.51.3-0.10.31.2-0.80.9-0.70.4-0.30.8-0.80.80.51.1
Pavlov. Cond. intertrial magazine entries1.21.63.4-0.70.91.3-1.41.3-1.31.2-1.11.7-0.90.91.11.8
Pavlov. Cond. lever-magazine prob. diff.0.40.51.4-0.0-0.3-0.90.4-0.60.4-0.30.3-0.61.2-1.2-0.8-1.0
Pavlov. Cond. response bias0.81.02.60.4-0.6-1.60.9-1.00.8-0.70.7-1.11.3-1.3-0.9-1.4
Time in closed arm before self-admin0.60.73.00.7-0.5-1.70.9-1.20.8-0.60.7-0.70.3-0.3-0.4-0.7
Time in closed arm after self-admin1.21.22.31.3-1.3-0.31.1-1.01.3-1.51.5-1.20.7-0.7-0.7-0.8
Time in open arm before self-admin0.50.51.8-0.7-0.20.8-0.20.4-0.10.0-0.1-0.31.1-1.1-1.4-0.7
Time in open arm after self-admin0.60.61.2-0.80.60.9-0.81.0-0.81.0-1.10.8-0.30.30.30.9
Bone: periosteal estimation4.18.511.72.5-3.0-3.22.8-3.02.7-2.62.5-2.73.4-3.4-3.1-2.9
Bone: periosteal perimeter3.25.47.32.3-2.4-2.72.3-2.62.2-2.22.1-2.02.5-2.5-2.2-2.1
Bone: post-yield work2.83.97.51.2-2.1-1.21.5-1.61.6-1.71.6-1.72.7-2.7-2.7-2.2
Progressive ratio test 1 active lever presses2.62.85.72.4-2.1-0.32.1-1.62.1-2.12.1-1.80.8-0.8-0.7-0.6
Progressive ratio test 1 breakpoint3.03.26.42.5-2.3-0.42.2-1.72.2-2.22.2-1.90.9-0.9-0.8-0.7
Progressive ratio test 1 inactive lever presses2.73.06.32.5-2.2-0.92.0-1.82.1-2.22.1-1.80.9-0.9-0.9-0.8
Progressive ratio test 2 active lever presses1.61.74.92.2-1.6-0.51.7-1.21.6-1.81.7-1.40.1-0.1-0.1-0.1
Progressive ratio test 2 breakpoint1.82.05.72.4-1.7-0.51.8-1.31.8-1.91.8-1.5-0.00.00.0-0.1
Progressive ratio test 2 inactive lever presses4.14.710.03.2-2.8-0.92.5-2.12.6-2.72.7-2.31.2-1.2-1.2-0.9
Incentive Sensitization - Responses0.50.51.91.4-0.7-0.50.9-0.50.8-0.80.8-0.7-0.40.40.50.2
Incentive Sensitization - Breakpoint0.50.52.01.4-0.7-0.60.8-0.50.8-0.80.8-0.7-0.40.40.50.1
Sum of active levers in priming session hrs 5-60.30.20.7-0.80.8-0.9-0.4-0.1-0.50.6-0.50.3-0.10.10.2-0.2
Progressive ratio0.30.30.50.6-0.7-0.20.4-0.20.4-0.70.7-0.60.6-0.6-0.5-0.6
Food seeking constrained by brief footshock0.30.40.9-0.90.70.4-0.80.8-0.80.5-0.50.70.2-0.2-0.30.2
Seeking ratio, punishment vs. effort0.30.31.1-1.10.80.1-0.60.4-0.60.8-0.80.60.0-0.0-0.3-0.0
Retroperitoneal fat weight0.00.20.40.6-0.5-0.60.1-0.30.2-0.20.2-0.10.6-0.6-0.20.4
Reaction time number correct0.30.41.2-0.7-0.20.7-0.50.5-0.30.3-0.30.51.0-1.0-1.1-0.4
Reaction time mean minus median0.30.40.80.7-0.5-0.40.8-0.70.7-0.90.8-0.90.1-0.10.1-0.4
Reaction time mean minus median AUC0.20.20.50.5-0.2-0.10.5-0.30.4-0.70.6-0.7-0.40.40.5-0.1
Reaction time num false alarms1.11.53.60.4-1.0-0.80.9-0.80.8-0.90.9-0.81.9-1.9-1.8-1.7
Reaction time num false alarms AUC1.92.66.40.6-1.5-1.11.1-1.11.0-1.11.2-1.02.5-2.5-2.4-2.0
Reaction time trials correct on left0.30.41.2-0.7-0.20.7-0.50.5-0.30.3-0.30.51.0-1.0-1.1-0.4
Reaction time trials on left0.30.41.3-0.7-0.20.7-0.50.5-0.30.3-0.20.51.1-1.1-1.1-0.4
Reaction time mean0.30.40.7-0.70.90.0-0.40.2-0.60.7-0.80.6-0.70.70.50.5
Reaction time mean AUC0.40.60.9-0.90.90.4-0.60.5-0.80.9-1.00.8-0.70.70.60.7
Median of all reaction times0.81.12.0-1.31.40.3-1.00.7-1.11.4-1.41.2-0.90.90.60.9
Reaction time omissions1.72.33.90.8-1.6-0.51.5-1.21.4-1.41.4-1.42.0-2.0-1.9-1.8
Reaction time false alarm rate1.42.03.80.9-1.3-1.21.2-1.21.1-1.11.2-1.21.9-1.9-1.8-1.7
Reaction time premature initiation rate2.23.04.5-1.71.61.7-2.12.1-2.11.9-1.91.9-1.21.21.21.5
Reaction time premature initiations1.52.24.0-1.71.11.8-1.92.0-1.91.6-1.51.8-0.40.40.31.0
Std. dev. reaction times0.10.20.30.3-0.4-0.20.5-0.50.4-0.50.5-0.60.5-0.5-0.3-0.3
Reaction time trials completed0.30.41.3-0.7-0.20.7-0.50.5-0.30.3-0.20.51.1-1.1-1.1-0.4
Reaction time trials AUC0.30.41.1-0.7-0.20.5-0.40.4-0.20.3-0.20.51.0-1.0-1.0-0.4
Run reversals in cocaine runway, females0.10.10.30.6-0.2-0.30.00.0-0.1-0.20.20.2-0.20.20.20.4
Run reversals in cocaine runway, males0.10.10.60.10.1-0.80.3-0.50.2-0.20.3-0.3-0.20.20.1-0.2
Latency to leave start box in cocaine runway2.52.74.5-1.21.81.0-1.61.3-1.51.5-1.51.5-2.12.12.11.7
Latency to leave start box in cocaine runway, F1.31.43.9-0.31.3-0.3-1.10.5-0.90.8-0.91.0-1.71.72.01.2
Latency to leave start box in cocaine runway, M4.24.17.4-1.91.92.7-1.82.1-1.81.9-2.01.8-2.12.11.82.2
Std. dev. time between licks in bursts0.81.01.91.2-1.3-0.70.7-0.70.7-1.11.1-0.61.4-1.4-1.0-0.4
Total sessions with >9 infusions2.93.26.62.6-2.1-1.32.3-2.12.3-2.02.0-2.00.7-0.7-0.5-1.0
Short access day 1 total inactive lever presses1.82.04.82.2-1.9-0.61.6-1.51.6-1.71.7-1.40.7-0.7-0.7-0.2
Short access day 10 total inactive lever presses1.21.33.41.4-1.1-1.81.0-1.20.9-1.21.1-1.00.9-0.9-0.9-1.2
Short access day 1 total infusions2.93.16.22.5-2.0-0.92.5-2.02.4-2.12.0-2.20.4-0.4-0.4-0.7
Short access day 10 total infusions1.61.74.12.0-1.5-0.41.8-1.51.8-1.61.6-1.4-0.00.00.1-0.2
Short access total infusions2.12.35.72.4-1.8-0.22.2-1.62.1-1.81.8-1.7-0.20.20.30.0
Short access day 1 locomotion1.82.03.41.8-1.7-0.61.8-1.51.8-1.61.6-1.60.7-0.7-0.8-0.7
Short access day 10 total locomotion4.14.67.42.7-2.3-2.12.6-2.52.6-2.52.5-2.30.9-0.9-1.1-1.6
Short access total locomotion5.76.010.03.2-2.9-1.43.1-2.63.1-2.92.9-2.81.1-1.1-1.1-1.6
One hour access (0.3 mA shock)3.23.87.02.7-2.3-1.72.1-2.02.2-2.22.2-1.91.3-1.3-1.3-1.3
Compulsive drug intake0.40.42.20.20.5-1.5-0.2-0.5-0.10.2-0.20.3-0.80.81.00.0
One hour access (shock baseline)3.13.66.12.4-2.5-0.92.1-1.72.1-2.22.1-1.91.6-1.6-1.7-1.0
Social response proportion2.02.24.1-1.52.00.0-1.40.9-1.51.3-1.31.4-1.81.81.91.1
Social responses1.62.15.11.7-1.2-2.31.4-1.91.5-1.61.6-1.40.8-0.8-0.6-1.2
Social time0.10.20.70.0-0.0-0.80.3-0.80.3-0.20.3-0.20.1-0.1-0.2-0.5
Soleus weight3.811.114.02.6-3.2-3.73.3-3.63.4-3.13.1-3.33.4-3.4-3.3-3.7
Bone: stiffness4.26.78.62.7-2.7-2.92.8-2.92.7-2.42.3-2.72.5-2.5-2.1-2.1
Tibialis anterior weight1.75.88.82.6-2.3-3.02.7-2.92.6-2.52.4-2.32.0-2.0-1.5-2.1
Time to tail flick, vehicle, before self-admin0.60.61.00.5-0.7-0.40.8-0.40.7-0.70.8-0.90.8-0.8-0.9-1.0
Time to tail flick, vehicle, after self-admin0.30.30.50.7-0.30.50.5-0.30.6-0.50.5-0.4-0.70.70.70.2
Time to tail flick, test, before self-admin0.10.10.40.00.4-0.60.1-0.30.20.1-0.1-0.1-0.50.50.6-0.1
Time to tail flick, test, after self-admin0.40.41.2-0.40.8-1.1-0.5-0.0-0.40.2-0.30.4-0.90.90.8-0.1
Delta time to tail flick, vehicle, before/after SA0.30.30.70.6-0.10.00.3-0.40.3-0.20.1-0.0-0.80.80.90.7
Delta time to tail flick, test, before/after SA0.20.10.3-0.40.2-0.3-0.60.3-0.60.3-0.30.50.2-0.2-0.5-0.1
Tibia length2.05.68.02.1-2.5-2.12.1-2.22.3-2.32.2-2.42.8-2.8-2.5-2.4
Ambulatory time before self-admin0.60.62.70.6-0.4-1.60.5-1.10.6-0.40.4-0.70.7-0.7-0.6-1.0
Ambulatory time after self-admin1.61.73.11.8-1.5-1.51.4-1.71.3-1.31.4-1.20.9-0.9-0.9-0.8
Bone: tissue strength2.62.54.11.3-1.6-1.41.3-1.41.4-1.51.5-1.52.0-2.0-1.8-1.8
Total heroin consumption0.20.20.6-0.60.8-0.6-0.1-0.2-0.10.4-0.3-0.1-0.50.50.6-0.2
Bone: trabecular number0.60.92.10.3-0.8-0.90.8-0.80.8-0.40.4-0.91.3-1.3-1.4-1.3
Bone: trabecular spacing0.60.81.7-0.20.71.0-0.70.8-0.70.4-0.50.9-1.11.11.31.2
Bone: trabecular thickness0.40.41.10.1-0.3-1.10.5-0.90.5-0.30.4-1.00.6-0.6-0.6-0.9
Bone: trabecular tissue density0.40.51.00.8-0.7-0.90.7-0.80.8-0.60.6-1.00.5-0.5-0.5-0.7
Water consumed over 24 hours2.52.95.0-2.22.11.5-1.81.8-1.91.9-1.91.7-1.31.31.21.0
Number of responses in last shaping day2.02.04.02.0-1.9-0.41.8-1.51.8-1.71.7-1.50.7-0.7-0.7-0.5