Hub : Genes

Hmga1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Hmga1	0.11	0.06	2.7e-04	0.01	0.01	0.01	0.01	6.5e-02	1.0e-02	1.8e-02	1.7e-02
2	Eye	intron excision ratio	chr20_5613598_5613843	0.49	0.15	1.5e-03	-0.02	-0.02	-0.02	-0.02	6.8e-01	8.7e-01	9.9e-01	8.4e-01
3	Adipose	gene expression	Hmga1	0.04	0.03	2.0e-03	0.02	0.01	0.02	0.01	1.5e-03	2.4e-02	1.1e-03	2.5e-02
4	BLA	alternative TSS	XM_006256164.4	0.08	0.05	1.3e-03	0.07	0.04	0.04	0.04	1.9e-04	2.7e-03	4.1e-03	3.8e-03
5	BLA	alternative TSS	XM_063278937.1	0.08	0.05	1.1e-03	0.07	0.04	0.04	0.05	1.4e-04	2.1e-03	2.7e-03	1.8e-03
6	NAcc	mRNA stability	Hmga1	0.03	0.02	8.8e-03	0.02	0.01	0.02	0.01	1.6e-03	6.4e-03	1.1e-03	2.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.3	0.6	1.5	0.0	0.4	-0.3	1.2	1.2	-0.3
Area under the delay curve	0.1	0.2	0.5	-0.3	-0.3	0.5	0.1	0.1	0.7
BMI with tail	1.4	4.9	9.5	-2.8	3.1	-1.7	-2.2	-2.2	0.1
BMI without tail	1.1	3.5	5.0	-2.2	2.0	-2.2	-1.7	-1.7	-1.0
Body weight	1.6	6.8	12.3	-0.6	2.5	-2.5	-3.5	-3.5	1.8
Weight adjusted by age	1.4	2.2	4.9	0.4	-0.3	0.9	-1.9	-1.9	2.2
Bone surface	0.2	0.4	2.0	1.4	-0.2	-0.3	0.0	0.0	0.4
Bone volume	0.1	0.1	0.3	0.5	0.2	-0.5	0.4	0.4	-0.0
Breakpoint value in progressive ratio session	0.3	0.3	1.0	-0.1	0.3	-1.0	0.3	0.3	-0.9
Number of licking bursts	0.5	0.9	2.9	1.7	-0.9	0.9	0.5	0.5	0.3
Context. condit. distance diff. score	3.7	4.4	8.9	3.0	-1.9	2.7	1.6	1.6	1.4
Locomotion velocity, session 1	1.6	1.7	3.5	1.2	-1.9	0.8	1.5	1.5	-0.1
Locomotion distance, session 1	0.7	0.9	1.7	0.5	-1.3	0.9	1.1	1.1	-0.6
Locomotion velocity, session 2	0.6	0.7	1.9	1.4	-1.0	0.1	0.9	0.9	-0.2
Locomotion distance, session 2	0.5	0.6	1.7	0.7	-0.8	1.3	0.5	0.5	0.6
Locomotion velocity, session 3	0.5	0.6	1.8	-0.1	-1.0	-0.2	0.7	0.7	-1.3
Locomotion distance, session 3	1.5	1.7	2.6	0.4	-1.5	1.2	1.6	1.6	-0.8
Stereotopy head waving bouts, day 3	0.9	1.0	1.9	1.4	-0.5	0.0	-1.2	-1.2	1.1
Stereotopy head waving duration, day 3	0.3	0.3	0.5	0.7	-0.7	-0.0	-0.6	-0.6	0.4
Locomotion velocity, session 7	1.6	1.7	4.2	0.6	-1.0	2.1	1.3	1.3	1.0
Locomotion distance, session 7	2.6	3.3	5.5	0.6	-1.7	2.4	2.3	2.3	0.0
Stereotopy head waving bouts, day 7	1.3	1.4	3.6	-0.6	-0.6	-1.3	1.1	1.1	-1.9
Stereotopy head waving duration, day 7	0.5	0.6	1.7	-0.6	-0.1	-1.3	0.2	0.2	-1.2
Locomotion velocity, session 8	2.6	3.1	9.4	3.1	-2.2	1.4	0.7	0.7	1.2
Locomotion distance, session 8	3.2	4.6	9.7	2.9	-2.0	3.1	1.2	1.2	1.6
Degree of sensitization distance	0.5	0.5	1.3	0.9	0.4	0.4	-0.5	-0.5	1.1
Degree of sensitization stereotypy	2.0	2.2	5.0	-0.8	-0.7	-0.9	1.8	1.8	-2.2
Conditioned locomotion	1.1	1.2	2.1	0.4	1.5	-0.5	-1.3	-1.3	1.1
Cocaine response after cond. corrected	0.8	1.0	1.7	0.3	1.3	0.2	-1.1	-1.1	1.3
Cocaine response after cond. not corrected	0.8	1.0	1.8	0.9	0.7	0.1	-1.3	-1.3	1.0
Cocaine response before conditioning	0.5	0.6	1.4	1.0	-1.2	-0.3	-0.8	-0.8	-0.4
Saline control response	3.6	4.7	9.9	-2.9	2.5	-3.1	-1.0	-1.0	-1.4
Bone: connectivity density	0.2	0.3	0.5	0.7	0.5	0.1	0.3	0.3	0.7
Bone: cortical apparent density	1.1	1.5	2.4	-1.5	1.5	-1.2	-1.2	-1.2	-0.4
Bone: cortical area	0.0	0.0	0.1	0.1	0.1	-0.1	-0.0	-0.0	-0.3
Bone: cortical porosity	2.5	2.7	4.4	-0.7	-1.6	-0.1	2.1	2.1	-2.0
Bone: cortical porosity	1.7	1.8	3.2	-0.2	-1.7	0.4	1.8	1.8	-1.2
Bone: cortical thickness	0.9	1.6	4.4	-2.1	0.9	-0.9	0.2	0.2	-1.9
Bone: cortical thickness	2.4	2.9	5.6	-2.4	2.2	-1.8	-0.8	-0.8	-1.4
Bone: cortical tissue density	1.0	1.4	1.9	-1.4	1.4	-1.2	-1.2	-1.2	-0.2
Condit. Reinf. active minus inactive responses	0.4	0.4	1.0	-0.2	-0.5	-0.1	1.0	1.0	-0.5
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.9	-1.1	1.0	-1.4	-0.2	-0.2	-0.7
Condit. Reinf. active responses	0.1	0.2	0.4	-0.4	0.2	0.0	0.6	0.6	-0.1
Condit. Reinf. inactive responses	0.3	0.3	0.8	-0.3	0.3	0.4	0.9	0.9	-0.1
Incentive salience index mean	0.9	1.1	1.6	1.1	-0.9	1.1	1.3	1.3	0.4
Condit. Reinf. lever presses	1.8	2.5	5.0	2.2	-1.0	2.1	1.1	1.1	1.5
Condit. Reinf. active minus inactive responses	0.2	0.3	1.4	0.4	-1.2	0.4	-0.2	-0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.7	0.5	-0.9	0.7	-0.4	-0.4	0.4
Condit. Reinf. active responses	0.2	0.3	1.1	0.3	-1.1	0.3	0.1	0.1	-0.5
Condit. Reinf. inactive responses	0.2	0.2	0.6	-0.4	0.1	-0.8	0.0	0.0	-0.7
Condit. Reinf. lever presses	1.1	1.5	2.9	-0.0	-1.3	0.5	1.7	1.7	-1.2
Condit. Reinf. lever reinforcers received	0.3	0.4	1.6	0.3	-1.3	0.4	0.4	0.4	-0.7
Conditioned reinforcement - actives	0.1	0.1	0.5	-0.2	-0.0	0.3	0.2	0.2	0.7
Conditioned reinforcement - inactives	0.1	0.2	0.6	-0.4	-0.5	0.8	0.2	0.2	-0.0
Conditioned locomotion	0.4	0.6	2.2	0.1	-0.3	0.9	0.3	0.3	1.5
Patch foraging indifference point 0 sec	1.5	2.8	5.4	-2.3	2.0	-1.9	-1.2	-1.2	-0.8
Patch foraging indifference point AUC	0.3	0.5	1.9	1.4	-0.6	-0.5	-0.1	-0.1	-0.7
Delay disc. indifference point, 0s delay	0.4	0.5	1.2	0.5	-0.6	0.9	0.0	0.0	1.1
Delay disc. indifference point, 16s delay	0.3	0.3	1.0	-1.0	-0.3	0.6	0.4	0.4	-0.2
Delay disc. indifference point, 2s delay	0.5	0.5	1.4	0.4	-0.8	1.0	-0.0	-0.0	1.2
Delay disc. indifference point, 24s delay	0.3	0.4	1.8	-1.4	-0.3	0.5	0.1	0.1	0.2
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.1	0.0	-0.6	-0.6	-0.6	0.6
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.4	-0.1	0.5	0.3	0.3	0.4
Indifference point function ln k	0.3	0.6	1.3	0.5	-1.1	0.8	0.8	0.8	-0.3
Indifference point function log k	0.3	0.6	1.3	0.5	-1.1	0.8	0.8	0.8	-0.3
Patch foraging total patch changes 0 sec	1.5	2.9	6.2	-2.5	2.0	-1.8	-1.2	-1.2	-1.0
Patch foraging total patch changes 12 sec	0.9	1.2	1.5	-1.1	1.0	-1.2	-1.2	-1.2	-1.0
Patch foraging total patch changes 18 sec	2.1	3.1	6.7	-2.0	2.6	-2.0	-1.3	-1.3	-0.8
Patch foraging total patch changes 24 sec	0.8	1.3	4.0	-2.0	1.5	-1.0	0.2	0.2	-0.8
Patch foraging total patch changes 6 sec	1.4	2.1	6.1	-2.5	1.7	-1.3	-0.8	-0.8	-1.0
Patch foraging time to switch 0 sec	1.1	2.2	4.7	-1.8	2.2	-0.3	-1.4	-1.4	0.9
Patch foraging water rate 0 sec	0.1	0.3	0.7	0.1	-0.0	0.3	-0.9	-0.9	0.4
Patch foraging water rate 12 sec	0.2	0.4	1.2	-0.7	0.0	-0.1	0.5	0.5	-1.1
Patch foraging water rate 18 sec	0.2	0.2	0.4	-0.5	0.6	-0.2	-0.6	-0.6	0.2
Patch foraging water rate 24 sec	0.1	0.1	0.4	-0.2	-0.3	0.0	-0.4	-0.4	-0.6
Patch foraging water rate 6 sec	0.1	0.1	0.5	-0.1	0.1	-0.2	-0.4	-0.4	-0.7
Seeking ratio, delayed vs. immediate footshock	1.3	1.6	6.3	-0.2	0.5	-2.5	-0.5	-0.5	-1.5
Distance traveled before self-admin	0.7	0.9	1.6	1.1	0.5	-0.2	-1.3	-1.3	0.7
Distance traveled after self-admin	1.1	1.4	2.4	0.5	0.9	-1.5	-1.5	-1.5	-0.0
Extensor digitorum longus weight	0.4	1.5	4.6	2.2	-1.2	0.9	0.0	0.0	1.4
Bone: elastic displacement	0.7	0.8	1.5	-1.2	-0.8	0.0	0.9	0.9	-1.1
Bone: elastic work	0.2	0.3	1.2	-1.1	-0.0	-0.3	0.1	0.1	-0.5
Bone: endosteal estimation	1.5	3.2	6.1	2.3	0.3	-0.4	-2.0	-2.0	2.5
Bone: endosteal perimeter	0.9	2.0	6.0	2.4	-0.0	0.3	-0.9	-0.9	2.1
Epididymis fat weight	4.8	16.5	46.3	-6.8	5.3	-2.8	-2.5	-2.5	-1.9
Delta time in closed arm before/after self-admin	0.4	0.3	1.4	-1.2	0.3	0.4	-0.3	-0.3	0.4
Delta time in open arm before/after self-admin	0.1	0.1	0.4	0.6	-0.0	-0.1	0.1	0.1	0.3
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	0.3	0.2	0.6	0.3	0.3	0.1
Delay discount exponential model param	0.1	0.1	0.3	0.3	0.4	-0.4	-0.2	-0.2	-0.6
Extinction: sum of active levers before priming	0.1	0.1	0.4	0.3	-0.3	0.7	-0.0	-0.0	0.2
Active lever presses in extinction session 6	0.6	0.6	2.1	-1.4	0.4	0.1	0.7	0.7	-0.4
Bone: final force	2.4	3.9	6.5	-1.8	2.6	-1.9	-2.2	-2.2	0.3
Bone: final moment	1.5	2.4	3.9	-1.6	2.0	-1.4	-1.8	-1.8	0.4
Food consumed during 24 hour testing period	1.2	1.7	3.0	0.0	1.7	-0.9	-1.5	-1.5	1.3
Glucose	3.3	5.3	10.6	3.0	-2.4	3.2	0.3	0.3	2.4
Heart weight	0.4	0.7	2.0	-0.4	-1.2	1.4	-0.5	-0.5	0.4
Delay discount hyperbolic model param	0.1	0.1	0.3	0.2	0.5	-0.4	-0.3	-0.3	-0.4
Intermittent access intake day 1-15 change	0.2	0.4	1.6	-0.3	0.5	-1.3	-0.2	-0.2	-0.8
Intermittent access intake escalation	0.5	1.1	3.4	-1.0	0.8	-1.8	0.1	0.1	-1.3
Intermittent access intake escalation 2	0.2	0.3	0.5	0.5	-0.4	-0.5	0.7	0.7	-0.2
Intermitt. access day 1 inactive lever presses	0.2	0.7	2.0	1.4	-0.4	0.3	-1.0	-1.0	-0.3
Intermitt. access day 15 inactive lever presses	0.2	0.5	0.9	0.3	0.5	-0.8	-1.0	-1.0	0.2
Intermitt. access escalation Index	0.2	0.3	1.3	1.2	-0.3	-0.0	0.2	0.2	-0.3
Intermittent access day 1 total infusions	1.4	2.2	4.4	-0.1	-1.3	2.1	1.8	1.8	0.9
Intermittent access day 15 total infusions	0.3	0.5	1.2	-0.7	-0.1	-0.0	1.1	1.1	-0.4
Intermittent access terminal intake (last 3 days)	0.4	0.5	0.9	-0.7	-0.5	0.4	1.0	1.0	-0.3
Intermittent access total infusions	0.6	0.7	1.4	-0.4	-0.7	0.8	1.2	1.2	0.1
Intermittent access day 1 locomotion	0.1	0.2	0.8	0.2	0.1	0.3	0.2	0.2	0.9
Intermittent access day 15 total locomotion	0.3	0.6	1.1	-0.4	0.7	-0.8	-0.8	-0.8	1.1
Intermittent access total locomotion	0.2	0.2	0.9	-0.0	0.5	-0.3	-0.1	-0.1	0.9
Intermittent access standard deviation	1.0	2.2	3.1	-1.4	1.7	-1.8	-1.5	-1.5	-0.6
Left kidney weight	1.0	4.6	9.4	-1.0	2.2	-3.1	-2.5	-2.5	0.2
Right kidney weight	1.2	5.7	9.5	-0.5	2.5	-3.1	-2.9	-2.9	1.0
Cocaine induced anxiety	0.5	0.8	2.5	1.6	0.5	-0.3	-0.8	-0.8	0.6
Post-drug Anxiety	0.7	0.7	1.5	0.7	1.2	-0.5	-1.0	-1.0	0.4
Baseline Anxiety	0.5	0.6	2.5	-1.6	0.9	0.3	-0.4	-0.4	0.1
Tail length	0.5	2.1	5.6	2.4	-1.1	-1.1	-1.4	-1.4	0.7
Length with tail	1.1	4.6	7.3	2.7	-0.4	-1.2	-2.5	-2.5	2.4
Length without tail	2.1	6.8	13.2	1.2	1.3	-0.4	-3.5	-3.5	3.6
Times rat made contact with spout	1.8	2.0	3.9	-1.7	0.2	-1.3	1.4	1.4	-2.0
Lifetime Intake	0.4	0.5	1.0	-0.5	-0.6	0.7	1.0	1.0	0.3
Liver weight, left	1.5	2.4	4.6	2.1	0.7	-0.7	-1.6	-1.6	2.0
Liver weight, right	2.0	3.5	12.3	3.5	-0.9	0.3	-1.1	-1.1	2.3
Locomotor activity	0.3	0.5	1.4	0.5	-0.1	-1.2	-0.7	-0.7	-0.7
Locomotor testing distance	0.3	0.5	1.0	-0.0	0.6	-0.8	-1.0	-1.0	-0.3
Locomotor testing rearing	0.7	1.4	3.1	0.3	1.1	-0.6	-1.8	-1.8	0.8
Locomotion in novel chamber	0.0	0.0	0.2	0.0	-0.4	0.0	0.2	0.2	-0.1
Locomotion in novel chamber post-restriction	0.8	1.4	1.8	-1.1	1.3	-1.3	-1.3	-1.3	0.4
Fecal boli incidents, locomotor time 1	0.2	0.3	1.3	-0.3	0.5	0.6	0.2	0.2	1.1
Change in fecal boli incidents, locomotor task	0.9	0.9	2.5	0.2	0.4	0.1	-1.6	-1.6	0.4
Time >=10cm from walls, locomotor time 1	3.2	3.4	6.0	0.4	2.2	-1.3	-2.5	-2.5	1.3
Bouts of movement, locomotor time 1	0.5	0.5	1.2	0.8	-0.2	-1.1	0.6	0.6	-0.6
Total resting periods, locomotor time 1	0.3	0.4	1.0	1.0	-0.1	-0.9	0.4	0.4	-0.2
Rest time, locomotor task time 1	0.7	0.9	1.4	1.2	-1.2	0.5	1.1	1.1	0.2
Distance moved, locomotor task time 1	0.8	1.2	2.3	-1.0	1.1	-0.6	-1.5	-1.5	0.1
Vertical activity count, locomotor time 1	1.4	3.3	5.1	-1.6	2.3	-1.8	-2.1	-2.1	0.1
Time >=10cm from walls, locomotor time 2	1.8	2.7	4.4	-0.8	1.6	0.0	-2.1	-2.1	2.0
Bouts of movement, locomotor time 2	0.7	1.1	4.0	1.2	-0.5	-2.0	0.4	0.4	-0.6
Total resting periods, locomotor time 2	0.8	1.4	2.7	1.7	-1.1	-1.6	0.8	0.8	-0.8
Rest time, locomotor task time 2	1.0	1.2	5.7	2.4	-0.8	0.4	0.1	0.1	1.0
Distance moved, locomotor task time 2	1.8	2.1	5.4	-2.3	1.8	-0.1	-1.3	-1.3	0.8
Vertical activity count, locomotor time 2	1.3	1.8	3.2	-1.8	1.6	-0.1	-1.4	-1.4	1.1
Light reinforcement 1	1.8	4.3	6.8	-0.5	2.5	-2.3	-2.6	-2.6	0.6
Light reinforcement 2	1.4	2.1	2.9	0.1	1.7	-1.6	-1.7	-1.7	1.2
Bone: marrow area	1.5	3.4	6.2	2.2	0.4	-0.5	-2.1	-2.1	2.5
Bone: maximum diameter	1.0	1.9	6.8	2.6	-1.2	1.0	0.3	0.3	1.3
Bone: maximum force	0.7	1.3	2.3	-0.7	1.2	-0.8	-1.5	-1.5	0.6
Bone: maximum moment	0.3	0.6	1.2	-0.4	0.6	-0.3	-1.1	-1.1	0.7
Mean time between licks in bursts	1.8	4.5	12.5	3.5	-2.7	2.0	1.1	1.1	0.9
Mean num. licks in bursts	1.1	1.7	5.6	-2.4	0.8	-1.4	0.2	0.2	-1.3
Cd content in liver	1.4	1.5	3.3	-0.9	1.4	0.5	-1.2	-1.2	1.8
Co content in liver	2.6	3.0	6.4	-2.1	2.5	-1.0	-1.7	-1.7	0.8
Cu content in liver	1.0	1.2	2.9	-1.6	0.0	-0.3	0.9	0.9	-1.7
Fe content in liver	0.3	0.3	0.5	-0.7	0.7	-0.5	-0.6	-0.6	0.0
K content in liver	1.0	1.0	1.4	1.2	-1.2	0.9	1.0	1.0	-0.0
Mg content in liver	1.6	1.6	6.0	2.5	-1.0	1.1	0.7	0.7	0.6
Mn content in liver	3.7	4.1	12.4	3.5	-1.6	2.3	-0.3	-0.3	2.1
Na content in liver	0.7	0.8	2.8	-0.4	-0.4	-0.7	0.7	0.7	-1.7
Rb content in liver	0.4	0.4	1.7	0.4	0.8	0.1	-0.1	-0.1	1.3
Se content in liver	3.0	3.5	8.4	2.9	-2.9	1.7	0.8	0.8	0.1
Sr content in liver	0.6	0.5	1.9	-0.2	0.1	1.1	-0.3	-0.3	1.4
Zn content in liver	1.2	1.3	2.4	1.4	-1.1	1.5	-0.6	-0.6	1.3
Bone: minimum diameter	0.7	1.3	3.0	1.7	0.3	0.3	-0.9	-0.9	1.7
Time in familiar zone, hab. session 1	1.8	1.8	3.6	-1.2	-0.0	-0.3	1.9	1.9	-1.3
Time in novel zone, hab. session 1	1.4	1.4	3.0	0.8	-0.3	0.4	-1.7	-1.7	1.1
Total zone transitions, hab. session 1	0.5	0.7	1.4	0.5	-1.2	1.1	0.6	0.6	-0.8
Total locomotion distance, hab. session 1	0.7	1.0	1.7	0.9	-1.3	1.2	0.9	0.9	-0.6
Locomotion velocity, hab. session 1	0.6	0.9	1.8	0.7	-1.3	0.9	0.9	0.9	-0.8
Time in familiar zone, hab. session 2	0.5	0.6	2.0	0.2	0.2	-1.4	-0.1	-0.1	-1.2
Time in novel zone, hab. session 2	0.3	0.3	0.9	-0.7	0.2	0.4	-0.2	-0.2	1.0
Total zone transitions, hab. session 2	0.2	0.2	0.7	0.8	-0.2	0.6	-0.3	-0.3	-0.0
Total locomotion distance, hab. session 2	0.4	0.5	1.4	1.2	-0.7	1.0	0.4	0.4	-0.2
Locomotion velocity, hab. session 2	0.8	1.1	2.1	1.4	-1.1	1.4	0.7	0.7	-0.3
Novel to familiar place preference ratio	0.2	0.2	0.7	-0.8	0.1	0.4	0.5	0.5	-0.2
Novelty place preference	0.1	0.2	0.5	-0.7	-0.0	0.3	0.4	0.4	-0.2
Time in novel zone, NPP test	0.1	0.1	0.4	-0.6	0.0	0.1	0.4	0.4	-0.2
Total zone transitions, NPP test	0.9	1.3	2.4	1.2	-1.3	1.6	1.0	1.0	0.1
Total locomotion distance, NPP test	0.5	0.7	2.7	0.5	-0.5	1.6	0.6	0.6	0.7
Locomotion velocity, NPP test	0.7	0.9	3.4	0.5	-0.5	1.9	0.8	0.8	0.4
Intraocular pressure	0.2	0.2	0.6	-0.0	0.8	-0.5	-0.0	-0.0	0.7
Delta distance traveled before/after self-admin	0.4	0.4	1.2	-0.8	0.1	-1.1	-0.2	-0.2	-0.7
Delta ambulatory time before/after self-admin	0.4	0.4	1.6	-0.3	0.4	-1.3	-0.5	-0.5	-0.5
Parametrial fat weight	2.0	4.8	9.8	-1.2	3.1	-2.7	-2.2	-2.2	0.7
Pavlov. Cond. lever latency	5.2	6.6	10.0	-2.4	3.2	-3.0	-2.7	-2.7	-0.1
Pavlov. Cond. magazine entry latency	3.0	3.9	6.8	2.2	-2.6	1.3	2.2	2.2	-0.7
Pavlov. Cond. change in total contacts	1.1	1.1	2.2	1.0	-1.5	0.8	1.2	1.2	-0.4
Pavlov. Cond. index score	4.6	5.8	9.3	2.5	-3.1	2.5	2.5	2.5	-0.1
Pavlov. Cond. latency score	4.5	5.6	8.8	2.4	-3.0	2.4	2.6	2.6	-0.2
Pavlov. Cond. lever contacts	4.0	4.7	8.6	2.2	-2.6	2.9	2.0	2.0	0.7
Pavlov. Cond. magazine entry number	2.5	3.1	5.3	-2.0	2.3	-1.5	-1.9	-1.9	0.5
Pavlov. Cond. intertrial magazine entries	1.0	1.2	3.5	-1.9	1.5	-0.5	-0.8	-0.8	0.2
Pavlov. Cond. lever-magazine prob. diff.	4.7	5.8	9.4	2.3	-3.1	2.5	2.6	2.6	-0.1
Pavlov. Cond. response bias	3.9	4.8	8.5	2.6	-2.9	2.4	2.0	2.0	0.1
Pavlov. Cond. lever latency	1.0	1.3	2.4	0.7	0.9	0.1	-1.5	-1.5	1.4
Pavlov. Cond. magazine entry latency	0.3	0.3	0.8	0.5	-0.3	0.1	0.9	0.9	0.4
Pavlov. Cond. change in total contacts	0.8	1.2	2.2	-0.7	-0.6	-0.7	1.4	1.4	-1.5
Pavlov. Cond. index score	0.6	0.8	1.9	-0.0	-0.8	-0.0	1.4	1.4	-0.7
Pavlov. Cond. latency score	0.5	0.7	1.5	-0.1	-0.8	-0.2	1.2	1.2	-0.7
Pavlov. Cond. lever contacts	0.8	1.1	1.9	-0.8	-0.6	-0.2	1.3	1.3	-1.4
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.2	-0.2	0.3	-0.5	-0.5	-0.1
Pavlov. Cond. intertrial magazine entries	0.6	0.9	4.6	2.1	-0.9	0.2	0.2	0.2	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.7	-0.1	-0.7	-0.1	1.3	1.3	-0.7
Pavlov. Cond. response bias	0.8	1.2	2.7	-0.1	-0.9	0.2	1.6	1.6	-0.9
Time in closed arm before self-admin	0.1	0.2	0.5	0.3	-0.2	0.7	-0.0	-0.0	0.5
Time in closed arm after self-admin	0.6	0.6	1.8	-0.9	-0.6	1.3	0.6	0.6	0.3
Time in open arm before self-admin	1.0	1.1	2.1	0.1	-0.9	0.1	1.4	1.4	-1.2
Time in open arm after self-admin	0.3	0.3	0.7	0.8	-0.4	-0.2	0.7	0.7	-0.4
Bone: periosteal estimation	0.6	1.2	2.2	1.5	0.2	-0.5	-1.3	-1.3	1.3
Bone: periosteal perimeter	0.1	0.2	0.9	1.0	0.2	-0.3	-0.3	-0.3	0.5
Bone: post-yield work	0.9	1.4	3.7	1.8	-0.3	0.7	-0.7	-0.7	1.9
Progressive ratio test 1 active lever presses	0.3	0.4	1.4	-0.5	-0.5	1.2	0.3	0.3	0.7
Progressive ratio test 1 breakpoint	0.4	0.4	1.5	-0.4	-0.5	1.2	0.3	0.3	0.8
Progressive ratio test 1 inactive lever presses	0.4	0.6	1.3	-1.0	1.1	-0.3	-0.8	-0.8	0.2
Progressive ratio test 2 active lever presses	0.4	0.4	0.8	-0.2	-0.6	0.8	0.9	0.9	0.1
Progressive ratio test 2 breakpoint	0.4	0.5	1.1	-0.2	-0.6	0.7	1.0	1.0	-0.0
Progressive ratio test 2 inactive lever presses	0.6	1.0	3.0	0.8	-0.9	1.7	0.5	0.5	1.0
Incentive Sensitization - Responses	0.4	0.6	1.0	0.6	-0.9	0.2	1.0	1.0	-0.5
Incentive Sensitization - Breakpoint	0.4	0.5	1.0	0.5	-0.7	0.0	1.0	1.0	-0.6
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.5	-0.0	-0.3	0.6	0.7	0.7	-0.4
Progressive ratio	2.3	3.6	5.9	-1.6	1.9	-2.4	-2.1	-2.1	-0.9
Food seeking constrained by brief footshock	0.7	0.8	1.8	-1.3	-0.1	-0.1	1.1	1.1	-0.7
Seeking ratio, punishment vs. effort	2.0	2.9	5.1	0.5	-1.8	1.9	2.3	2.3	-0.0
Retroperitoneal fat weight	0.1	0.5	1.0	-0.3	1.0	-0.6	-0.9	-0.9	0.5
Reaction time number correct	0.8	1.5	3.6	-1.9	1.3	-1.0	-0.9	-0.9	-1.0
Reaction time mean minus median	0.9	2.2	8.4	2.9	-1.3	0.4	1.0	1.0	1.2
Reaction time mean minus median AUC	1.0	2.5	5.7	2.4	-1.5	1.2	1.1	1.1	1.7
Reaction time num false alarms	0.3	0.4	1.4	1.2	-0.4	-0.6	0.0	0.0	-0.7
Reaction time num false alarms AUC	0.4	0.6	1.8	1.3	-0.7	-0.5	0.0	0.0	-1.0
Reaction time trials correct on left	0.8	1.5	3.6	-1.9	1.3	-1.0	-0.9	-0.9	-1.0
Reaction time trials on left	0.8	1.4	3.4	-1.8	1.3	-1.0	-0.9	-0.9	-1.0
Reaction time mean	1.3	2.0	5.0	2.2	-0.6	1.3	0.4	0.4	2.2
Reaction time mean AUC	1.1	1.8	4.7	2.0	-0.5	1.1	0.5	0.5	2.2
Median of all reaction times	1.0	1.4	4.6	1.5	-0.2	1.3	0.0	0.0	2.1
Reaction time omissions	0.8	1.1	4.9	2.2	-0.3	0.3	0.0	0.0	1.3
Reaction time false alarm rate	1.0	1.4	4.9	2.2	-1.5	0.4	0.7	0.7	-0.3
Reaction time premature initiation rate	0.1	0.2	0.3	-0.3	0.4	-0.5	-0.4	-0.4	0.4
Reaction time premature initiations	0.7	1.2	2.1	-1.5	1.2	-1.2	-1.1	-1.1	-0.1
Std. dev. reaction times	1.3	2.4	8.5	2.9	-1.4	0.6	0.9	0.9	1.4
Reaction time trials completed	0.8	1.4	3.4	-1.8	1.3	-1.0	-0.9	-0.9	-1.0
Reaction time trials AUC	0.8	1.5	3.3	-1.8	1.4	-1.0	-1.0	-1.0	-0.8
Run reversals in cocaine runway, females	0.5	0.5	1.8	-1.4	-0.2	0.8	0.2	0.2	0.5
Run reversals in cocaine runway, males	1.2	1.2	4.0	2.0	-1.3	0.4	0.8	0.8	0.5
Latency to leave start box in cocaine runway	0.8	0.9	4.7	0.5	-0.5	2.2	0.3	0.3	0.5
Latency to leave start box in cocaine runway, F	0.6	0.7	3.3	0.3	-0.4	1.8	0.2	0.2	0.8
Latency to leave start box in cocaine runway, M	0.2	0.2	1.3	0.2	-0.1	1.1	0.1	0.1	-0.2
Std. dev. time between licks in bursts	3.2	4.4	11.2	3.3	-2.6	2.4	0.6	0.6	1.3
Total sessions with >9 infusions	0.2	0.2	0.3	-0.4	-0.5	-0.0	0.6	0.6	-0.1
Short access day 1 total inactive lever presses	0.7	0.9	1.9	0.9	-1.4	1.1	0.5	0.5	1.1
Short access day 10 total inactive lever presses	0.5	1.1	2.2	0.9	0.7	-1.4	-0.8	-0.8	-1.5
Short access day 1 total infusions	0.5	0.6	1.5	0.0	-1.1	1.2	0.6	0.6	0.6
Short access day 10 total infusions	0.1	0.1	0.2	-0.5	-0.0	-0.3	0.5	0.5	-0.3
Short access total infusions	0.3	0.4	0.5	-0.5	-0.5	0.7	0.7	0.7	0.4
Short access day 1 locomotion	0.1	0.2	0.4	0.6	-0.5	0.4	0.2	0.2	-0.3
Short access day 10 total locomotion	0.8	1.4	3.2	1.1	0.2	-0.8	-1.8	-1.8	0.5
Short access total locomotion	0.5	0.6	1.2	0.6	0.3	-0.0	-1.1	-1.1	0.8
One hour access (0.3 mA shock)	1.2	1.4	2.2	1.1	-1.5	1.1	1.4	1.4	-0.3
Compulsive drug intake	1.0	1.1	4.0	2.0	-0.8	1.1	-0.5	-0.5	0.7
One hour access (shock baseline)	0.6	1.0	2.6	-0.4	-0.6	0.2	1.6	1.6	-0.3
Social response proportion	0.3	0.4	0.8	0.3	0.1	0.1	-0.9	-0.9	0.8
Social responses	0.3	0.4	0.8	0.5	0.0	-0.7	-0.9	-0.9	-0.1
Social time	1.4	1.9	10.4	3.2	-0.8	-0.4	-0.3	-0.3	0.3
Soleus weight	2.5	7.3	19.8	4.5	-2.2	2.1	-1.5	-1.5	3.2
Bone: stiffness	0.9	1.4	2.6	-0.6	1.6	-1.3	-1.4	-1.4	0.2
Tibialis anterior weight	0.1	0.2	0.9	-0.3	0.2	-0.9	-0.2	-0.2	-0.4
Time to tail flick, vehicle, before self-admin	1.0	1.0	2.2	1.1	1.0	-1.5	-0.9	-0.9	-0.2
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.6	0.8	0.0	-0.2	0.3	0.3	0.2
Time to tail flick, test, before self-admin	0.8	0.8	2.6	-0.0	-0.1	-1.2	0.6	0.6	-1.6
Time to tail flick, test, after self-admin	2.4	2.5	5.2	0.8	-1.3	-0.2	2.3	2.3	-1.5
Delta time to tail flick, vehicle, before/after SA	1.6	1.5	3.3	-1.0	-0.5	0.9	1.8	1.8	-0.3
Delta time to tail flick, test, before/after SA	0.1	0.2	0.4	-0.2	-0.1	0.4	0.6	0.6	-0.1
Tibia length	0.9	2.5	4.0	2.0	0.4	-0.8	-2.0	-2.0	1.4
Ambulatory time before self-admin	0.1	0.1	0.4	0.6	-0.1	0.1	-0.3	-0.3	0.0
Ambulatory time after self-admin	0.5	0.6	1.0	0.3	0.4	-1.0	-1.0	-1.0	-0.1
Bone: tissue strength	0.4	0.4	1.0	-0.6	0.3	0.4	-0.6	-0.6	1.0
Total heroin consumption	0.4	0.5	1.2	0.5	0.2	-1.1	-0.2	-0.2	-1.1
Bone: trabecular number	0.3	0.6	1.5	-0.1	0.3	-0.3	1.2	1.2	-0.5
Bone: trabecular spacing	0.6	0.9	2.1	-0.5	0.4	-0.6	-1.5	-1.5	0.4
Bone: trabecular thickness	0.3	0.4	0.7	0.2	0.7	-0.3	0.9	0.9	0.3
Bone: trabecular tissue density	0.4	0.7	1.8	0.3	-1.4	0.2	0.9	0.9	-0.7
Water consumed over 24 hours	0.1	0.1	0.3	0.5	-0.0	0.0	-0.1	-0.1	0.5
Number of responses in last shaping day	2.9	3.2	9.8	0.7	-2.7	3.1	0.6	0.6	0.9