Hub : Genes

Hmga1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Hmga1	0.07	0.04	1.5e-03	-0	0.01	0	0	4.2e-01	3.9e-02	2.2e-01	1.1e-01
2	NAcc	gene expression	Hmga1	0.02	0.01	6.7e-03	0.01	0.02	0.02	0	5.7e-02	2.7e-03	4.5e-03	9.0e-02
3	NAcc	alternative polyA	XM_006256164.3	0.02	0.01	9.2e-03	0.02	0	0	0.01	1.6e-03	1.2e-01	1.9e-01	2.9e-02
4	Eye	intron excision ratio	chr20_5611755_5612000	0.41	0.16	5.9e-03	-0.02	-0.02	-0.01	-0.02	7.0e-01	9.0e-01	5.3e-01	9.0e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.0	0.1	0.2	0.2	0.4	-0.1	0.0
Area under the delay curve	0.1	0.1	0.2	-0.4	0.1	-0.3	0.5
BMI with tail	2.0	6.6	8.3	-2.4	-2.2	2.7	-2.9
BMI without tail	0.7	1.5	3.2	-1.0	-1.8	1.1	-0.9
Body weight	0.7	2.8	5.6	-1.1	-1.1	1.8	-2.4
Weight adjusted by age	0.1	0.1	0.2	0.2	0.4	-0.2	0.2
Bone surface	0.5	0.8	1.7	1.3	1.0	-0.6	0.4
Bone volume	0.1	0.1	0.2	0.5	0.4	-0.2	0.2
Breakpoint value in progressive ratio session	0.4	0.5	1.7	0.0	-0.1	1.3	-0.3
Number of licking bursts	1.3	1.5	2.8	1.7	1.3	-1.0	0.9
Context. condit. distance diff. score	5.6	6.8	10.4	3.1	3.2	-1.9	1.9
Locomotion velocity, session 1	2.5	2.7	4.3	1.2	1.4	-2.1	1.8
Locomotion distance, session 1	0.9	1.2	2.3	0.7	0.7	-1.5	1.2
Locomotion velocity, session 2	1.1	1.2	1.9	1.4	1.0	-1.1	1.0
Locomotion distance, session 2	0.7	1.0	1.3	0.8	1.1	-1.1	0.8
Locomotion velocity, session 3	0.3	0.4	0.9	-0.0	-0.4	-0.7	1.0
Locomotion distance, session 3	1.0	1.1	2.2	0.6	0.7	-1.2	1.5
Stereotopy head waving bouts, day 3	0.6	0.7	1.7	1.3	0.9	-0.3	0.6
Stereotopy head waving duration, day 3	0.3	0.4	0.7	0.6	0.4	-0.7	0.8
Locomotion velocity, session 7	1.1	1.2	2.3	0.7	1.5	-0.9	1.1
Locomotion distance, session 7	1.8	2.2	2.9	0.8	1.6	-1.7	1.7
Stereotopy head waving bouts, day 7	0.4	0.5	0.8	-0.7	-0.9	-0.4	0.7
Stereotopy head waving duration, day 7	0.3	0.4	1.0	-0.7	-1.0	0.1	0.1
Locomotion velocity, session 8	5.3	6.4	8.8	3.0	2.8	-2.0	2.2
Locomotion distance, session 8	4.7	6.9	10.3	3.0	3.2	-2.1	2.0
Degree of sensitization distance	0.4	0.4	0.7	0.8	0.8	0.1	-0.4
Degree of sensitization stereotypy	0.5	0.5	1.0	-0.8	-1.0	-0.4	0.6
Conditioned locomotion	0.8	0.9	2.1	0.4	0.2	1.2	-1.5
Cocaine response after cond. corrected	0.6	0.7	1.4	0.3	0.3	1.0	-1.2
Cocaine response after cond. not corrected	0.3	0.3	0.7	0.8	0.5	0.3	-0.5
Cocaine response before conditioning	0.9	1.1	2.0	0.9	0.2	-1.4	1.2
Saline control response	5.9	7.7	9.8	-2.9	-3.1	2.5	-2.5
Bone: connectivity density	0.3	0.5	1.3	0.9	1.1	-0.2	-0.1
Bone: cortical apparent density	1.7	2.3	2.9	-1.6	-1.7	1.3	-1.4
Bone: cortical area	0.0	0.0	0.1	-0.1	-0.3	-0.1	-0.1
Bone: cortical porosity	1.3	1.4	2.5	-0.9	-0.5	-1.4	1.6
Bone: cortical porosity	1.3	1.4	2.9	-0.2	0.2	-1.6	1.7
Bone: cortical thickness	1.6	2.7	4.7	-2.1	-2.2	0.8	-1.0
Bone: cortical thickness	3.9	4.6	5.9	-2.1	-2.4	1.9	-2.1
Bone: cortical tissue density	1.5	1.9	2.5	-1.4	-1.6	1.2	-1.4
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	-0.2	0.0	-0.8	0.5
Condit. Reinf. active-inactive response ratio	1.0	1.0	1.4	-1.1	-1.2	0.7	-1.0
Condit. Reinf. active responses	0.0	0.1	0.2	-0.4	-0.0	-0.2	-0.2
Condit. Reinf. inactive responses	0.1	0.1	0.1	-0.3	0.1	0.2	-0.3
Incentive salience index mean	1.1	1.4	2.0	1.1	1.4	-1.2	0.9
Condit. Reinf. lever presses	2.2	3.0	5.3	2.0	2.3	-1.2	1.0
Condit. Reinf. active minus inactive responses	0.5	0.6	1.4	0.4	0.3	-1.2	1.0
Condit. Reinf. active-inactive response ratio	0.4	0.5	0.8	0.5	0.5	-0.9	0.7
Condit. Reinf. active responses	0.4	0.5	1.2	0.3	0.2	-1.1	0.9
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.3	-0.6	0.1	-0.1
Condit. Reinf. lever presses	0.5	0.7	2.0	-0.1	0.1	-1.4	0.9
Condit. Reinf. lever reinforcers received	0.6	0.9	2.1	0.4	0.3	-1.4	1.1
Conditioned reinforcement - actives	0.3	0.3	0.6	0.2	0.7	-0.8	0.3
Conditioned reinforcement - inactives	0.3	0.3	0.5	-0.6	-0.5	-0.7	0.3
Conditioned locomotion	0.7	0.9	1.8	0.3	1.3	-1.1	0.7
Patch foraging indifference point 0 sec	3.0	4.8	6.7	-2.4	-2.6	1.6	-2.0
Patch foraging indifference point AUC	0.9	1.1	1.8	1.3	0.4	-1.4	0.8
Delay disc. indifference point, 0s delay	0.4	0.4	0.9	0.5	0.9	-0.4	0.6
Delay disc. indifference point, 16s delay	0.3	0.3	0.7	-0.9	-0.4	-0.4	0.4
Delay disc. indifference point, 2s delay	0.4	0.4	0.5	0.3	0.7	-0.7	0.7
Delay disc. indifference point, 24s delay	0.7	0.7	2.0	-1.4	-0.7	-0.1	0.4
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	-0.0	-0.1	0.3	0.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.5	0.1	-0.1	0.2
Indifference point function ln k	0.4	0.5	1.0	0.5	0.6	-0.6	1.0
Indifference point function log k	0.4	0.5	1.0	0.5	0.6	-0.6	1.0
Patch foraging total patch changes 0 sec	3.3	5.3	7.7	-2.6	-2.8	1.6	-2.0
Patch foraging total patch changes 12 sec	1.1	1.4	2.9	-1.2	-1.7	0.5	-1.0
Patch foraging total patch changes 18 sec	4.2	5.4	6.8	-2.2	-2.5	1.9	-2.6
Patch foraging total patch changes 24 sec	2.2	2.6	4.0	-2.0	-1.9	0.8	-1.5
Patch foraging total patch changes 6 sec	2.9	4.2	6.4	-2.5	-2.5	1.2	-1.6
Patch foraging time to switch 0 sec	3.2	4.9	7.7	-1.9	-1.6	2.8	-2.4
Patch foraging water rate 0 sec	0.3	0.4	1.1	0.4	0.5	-1.1	0.3
Patch foraging water rate 12 sec	0.1	0.1	0.2	-0.4	-0.4	-0.4	0.2
Patch foraging water rate 18 sec	0.1	0.1	0.2	-0.4	-0.3	0.1	-0.4
Patch foraging water rate 24 sec	0.0	0.1	0.1	0.1	-0.1	-0.3	0.4
Patch foraging water rate 6 sec	0.1	0.1	0.3	0.2	0.1	-0.6	0.3
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.7	-0.3	-1.3	0.7	-0.5
Distance traveled before self-admin	0.6	0.7	1.5	1.2	0.6	0.7	-0.5
Distance traveled after self-admin	0.6	0.6	1.4	0.3	-0.6	1.2	-0.8
Extensor digitorum longus weight	0.7	2.9	4.4	2.1	2.0	-1.4	1.0
Bone: elastic displacement	0.7	0.8	1.3	-1.1	-0.7	-0.9	0.9
Bone: elastic work	0.3	0.4	1.2	-1.1	-0.7	-0.0	0.1
Bone: endosteal estimation	0.6	1.3	3.0	1.7	1.2	0.5	-0.4
Bone: endosteal perimeter	0.8	1.8	4.3	2.1	1.7	0.2	-0.1
Epididymis fat weight	8.7	20.2	29.2	-5.4	-4.9	3.7	-3.7
Delta time in closed arm before/after self-admin	0.3	0.3	0.4	-0.7	-0.3	0.6	-0.3
Delta time in open arm before/after self-admin	0.0	0.0	0.0	-0.0	-0.0	-0.0	0.1
Diff in mean of infusions in LGA sessions	0.2	0.2	0.5	0.4	0.7	0.3	0.0
Delay discount exponential model param	0.2	0.2	0.4	0.4	-0.1	0.4	-0.6
Extinction: sum of active levers before priming	0.0	0.0	0.0	0.2	0.2	0.1	0.0
Active lever presses in extinction session 6	0.9	0.9	2.0	-1.4	-0.6	0.9	-0.7
Bone: final force	3.7	6.0	7.5	-2.1	-2.2	2.7	-2.7
Bone: final moment	2.5	4.0	5.0	-1.9	-1.8	2.2	-2.1
Food consumed during 24 hour testing period	1.1	1.3	2.7	-0.0	-0.1	1.5	-1.7
Glucose	8.3	12.4	18.2	3.6	4.3	-3.0	3.1
Heart weight	1.7	2.4	4.9	0.5	0.7	-2.2	2.1
Delay discount hyperbolic model param	0.2	0.2	0.4	0.3	-0.1	0.4	-0.6
Intermittent access intake day 1-15 change	0.6	0.6	1.2	-0.4	-1.1	1.0	-0.3
Intermittent access intake escalation	0.3	0.3	1.0	0.3	-0.4	1.0	-0.2
Intermittent access intake escalation 2	2.3	2.3	4.1	2.0	1.7	-0.7	1.3
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.9	0.9	0.1	0.1	-0.1
Intermitt. access day 15 inactive lever presses	0.7	0.7	1.3	-0.4	-1.2	0.9	-0.8
Intermitt. access escalation Index	0.4	0.3	0.9	1.0	0.6	0.3	0.0
Intermittent access day 1 total infusions	1.0	1.1	2.1	-0.0	1.0	-1.5	1.2
Intermittent access day 15 total infusions	0.0	0.0	0.1	-0.1	0.1	-0.1	0.3
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.5	-0.1	0.3	-0.6	0.7
Intermittent access total infusions	0.3	0.4	0.7	-0.3	0.4	-0.9	0.7
Intermittent access day 1 locomotion	0.2	0.2	0.4	0.2	0.5	-0.7	0.2
Intermittent access day 15 total locomotion	0.1	0.1	0.4	-0.1	0.1	0.6	-0.3
Intermittent access total locomotion	0.1	0.1	0.2	0.1	0.4	-0.0	-0.4
Intermittent access standard deviation	2.5	2.6	4.0	-1.4	-2.0	1.5	-1.5
Left kidney weight	0.2	0.4	0.7	-0.5	-0.5	0.7	-0.8
Right kidney weight	0.1	0.4	0.8	0.3	-0.3	0.7	-0.9
Cocaine induced anxiety	0.9	1.0	2.8	1.7	0.8	0.4	-0.6
Post-drug Anxiety	0.7	0.8	1.8	1.3	0.6	0.4	-1.0
Baseline Anxiety	0.6	0.7	1.8	-1.3	-0.9	0.1	-0.3
Tail length	1.5	4.7	7.4	2.7	1.6	-2.1	2.1
Length with tail	0.5	1.8	2.7	1.6	1.4	-1.3	0.8
Length without tail	0.1	0.3	0.7	0.1	0.7	0.1	-0.8
Times rat made contact with spout	1.0	1.2	2.6	-1.6	-1.5	0.1	-0.3
Lifetime Intake	0.3	0.4	0.6	-0.3	0.4	-0.8	0.7
Liver weight, left	0.3	0.5	1.0	1.0	0.5	0.4	-0.8
Liver weight, right	3.6	5.9	11.6	3.4	2.4	-2.0	1.5
Locomotor activity	0.1	0.2	0.5	0.4	-0.7	0.3	0.3
Locomotor testing distance	0.3	0.6	1.0	-0.2	-1.0	1.0	-0.5
Locomotor testing rearing	0.6	0.9	1.8	0.2	-0.4	1.4	-1.2
Locomotion in novel chamber	0.2	0.3	0.6	0.2	0.4	-0.6	0.8
Locomotion in novel chamber post-restriction	1.1	1.3	1.8	-1.1	-0.9	1.3	-1.1
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.3	0.3	0.4	-0.4
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.5	0.2	-0.1	0.1
Time >=10cm from walls, locomotor time 1	2.7	2.7	6.0	0.2	-0.3	2.4	-2.2
Bouts of movement, locomotor time 1	0.2	0.3	0.8	0.9	0.4	-0.0	0.3
Total resting periods, locomotor time 1	0.4	0.4	1.2	1.1	0.6	-0.2	0.3
Rest time, locomotor task time 1	1.2	1.4	1.9	1.1	1.1	-1.4	1.1
Distance moved, locomotor task time 1	1.6	1.7	2.4	-1.2	-1.3	1.5	-1.2
Vertical activity count, locomotor time 1	4.9	5.2	7.8	-1.8	-2.0	2.8	-2.4
Time >=10cm from walls, locomotor time 2	2.0	2.1	4.7	-0.9	-0.5	2.2	-1.6
Bouts of movement, locomotor time 2	0.2	0.2	0.9	0.9	0.0	-0.2	0.3
Total resting periods, locomotor time 2	0.9	0.9	2.0	1.4	0.5	-0.8	0.9
Rest time, locomotor task time 2	2.4	2.7	5.8	2.4	1.9	-0.8	0.9
Distance moved, locomotor task time 2	2.8	3.2	5.2	-2.3	-1.5	1.6	-1.7
Vertical activity count, locomotor time 2	2.4	2.6	3.5	-1.9	-1.2	1.6	-1.7
Light reinforcement 1	2.3	4.2	8.3	-0.7	-1.4	2.5	-2.9
Light reinforcement 2	1.3	1.7	4.1	-0.1	-0.5	1.6	-2.0
Bone: marrow area	0.5	1.2	2.7	1.6	1.1	0.6	-0.5
Bone: maximum diameter	1.9	3.4	6.0	2.5	2.2	-1.3	1.1
Bone: maximum force	0.8	1.4	1.7	-1.1	-1.1	1.2	-1.3
Bone: maximum moment	0.3	0.5	0.7	-0.8	-0.7	0.7	-0.7
Mean time between licks in bursts	6.3	8.8	12.3	3.5	3.0	-2.8	2.5
Mean num. licks in bursts	2.1	2.5	5.2	-2.3	-1.9	0.7	-0.8
Cd content in liver	1.7	1.8	2.5	-1.6	-0.6	1.6	-1.4
Co content in liver	4.7	5.6	6.1	-2.3	-2.2	2.5	-2.5
Cu content in liver	0.4	0.5	1.4	-1.2	-0.5	-0.2	0.5
Fe content in liver	0.2	0.3	0.9	-0.9	-0.4	0.3	-0.1
K content in liver	3.6	3.6	4.1	1.9	1.9	-2.0	1.7
Mg content in liver	9.3	9.5	10.5	3.2	3.2	-3.2	2.7
Mn content in liver	6.7	7.7	11.9	3.4	3.1	-2.3	2.0
Na content in liver	0.1	0.1	0.3	0.3	0.2	-0.4	0.5
Rb content in liver	0.5	0.6	1.7	0.7	1.3	-0.0	-0.4
Se content in liver	11.7	14.3	16.8	3.6	3.3	-4.1	4.1
Sr content in liver	0.1	0.1	0.2	-0.2	0.4	0.4	-0.1
Zn content in liver	1.3	1.4	2.9	0.9	1.7	-1.0	0.9
Bone: minimum diameter	0.4	0.8	1.9	1.4	1.1	0.0	-0.3
Time in familiar zone, hab. session 1	0.4	0.4	1.2	-1.1	-0.7	-0.0	0.0
Time in novel zone, hab. session 1	0.2	0.2	0.6	0.8	0.5	-0.1	0.3
Total zone transitions, hab. session 1	0.6	0.8	1.5	0.6	0.4	-1.2	1.1
Total locomotion distance, hab. session 1	1.0	1.4	2.5	1.1	0.8	-1.6	1.2
Locomotion velocity, hab. session 1	0.9	1.3	2.5	0.9	0.6	-1.6	1.2
Time in familiar zone, hab. session 2	0.2	0.2	0.5	0.2	-0.7	0.4	-0.2
Time in novel zone, hab. session 2	0.2	0.2	0.7	-0.8	0.1	0.1	-0.2
Total zone transitions, hab. session 2	0.2	0.3	0.9	1.0	0.4	-0.3	0.2
Total locomotion distance, hab. session 2	0.7	0.9	2.0	1.4	0.9	-0.9	0.5
Locomotion velocity, hab. session 2	1.3	1.7	2.9	1.7	1.2	-1.3	1.0
Novel to familiar place preference ratio	0.1	0.2	0.5	-0.7	-0.3	0.0	-0.1
Novelty place preference	0.1	0.1	0.4	-0.6	-0.3	-0.1	0.1
Time in novel zone, NPP test	0.1	0.1	0.3	-0.6	-0.2	-0.1	0.1
Total zone transitions, NPP test	1.3	1.8	2.4	1.3	1.3	-1.5	1.2
Total locomotion distance, NPP test	0.4	0.6	1.2	0.6	1.1	-0.8	0.2
Locomotion velocity, NPP test	0.4	0.6	1.1	0.7	1.1	-0.8	0.3
Intraocular pressure	0.1	0.2	0.5	0.0	0.1	0.4	-0.7
Delta distance traveled before/after self-admin	0.5	0.5	1.2	-0.9	-1.1	0.3	0.1
Delta ambulatory time before/after self-admin	0.2	0.2	0.5	-0.4	-0.7	0.3	-0.2
Parametrial fat weight	1.2	2.4	3.9	-0.8	-1.3	1.8	-2.0
Pavlov. Cond. lever latency	6.6	8.4	9.8	-2.5	-2.9	3.1	-3.1
Pavlov. Cond. magazine entry latency	4.6	6.0	8.0	2.3	2.1	-2.8	2.5
Pavlov. Cond. change in total contacts	1.4	1.5	2.3	1.0	0.9	-1.5	1.4
Pavlov. Cond. index score	6.5	8.2	10.2	2.5	2.7	-3.2	3.0
Pavlov. Cond. latency score	6.2	7.9	9.7	2.5	2.7	-3.1	2.9
Pavlov. Cond. lever contacts	5.8	6.8	7.6	2.2	2.7	-2.8	2.7
Pavlov. Cond. magazine entry number	3.7	4.6	6.6	-2.0	-1.7	2.6	-2.2
Pavlov. Cond. intertrial magazine entries	1.7	2.1	3.4	-1.8	-1.3	1.2	-1.3
Pavlov. Cond. lever-magazine prob. diff.	6.4	7.9	10.0	2.4	2.7	-3.2	3.0
Pavlov. Cond. response bias	7.0	8.5	10.8	2.5	2.7	-3.3	3.1
Pavlov. Cond. lever latency	0.6	0.8	2.2	0.3	0.0	1.5	-1.0
Pavlov. Cond. magazine entry latency	0.1	0.2	0.5	0.3	0.7	-0.2	0.2
Pavlov. Cond. change in total contacts	0.3	0.4	0.5	-0.7	-0.6	-0.7	0.5
Pavlov. Cond. index score	0.3	0.3	0.8	-0.1	0.2	-0.9	0.7
Pavlov. Cond. latency score	0.2	0.3	0.6	-0.1	0.2	-0.8	0.6
Pavlov. Cond. lever contacts	0.4	0.6	1.0	-1.0	-0.8	-0.7	0.2
Pavlov. Cond. magazine entry number	0.0	0.1	0.1	0.3	-0.0	-0.2	0.3
Pavlov. Cond. intertrial magazine entries	1.6	2.2	4.8	2.2	1.2	-1.1	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.5	-0.2	0.1	-0.7	0.5
Pavlov. Cond. response bias	0.3	0.4	1.2	-0.4	-0.1	-1.1	0.6
Time in closed arm before self-admin	0.0	0.1	0.1	-0.0	0.3	-0.1	0.3
Time in closed arm after self-admin	0.2	0.2	0.6	-0.8	-0.2	0.0	0.3
Time in open arm before self-admin	0.8	0.8	1.6	0.5	0.4	-1.3	1.1
Time in open arm after self-admin	0.8	0.9	1.4	0.8	0.7	-1.2	1.0
Bone: periosteal estimation	0.2	0.4	1.0	1.0	0.5	0.4	-0.5
Bone: periosteal perimeter	0.1	0.2	0.4	0.6	0.3	0.3	-0.4
Bone: post-yield work	0.4	0.6	1.3	1.1	1.1	-0.1	-0.0
Progressive ratio test 1 active lever presses	0.6	0.7	1.1	-0.3	0.6	-1.1	1.1
Progressive ratio test 1 breakpoint	0.5	0.6	1.0	-0.4	0.5	-0.9	1.0
Progressive ratio test 1 inactive lever presses	0.8	0.9	1.1	-1.1	-1.0	0.9	-0.8
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.1	0.2	-0.1	0.3
Progressive ratio test 2 breakpoint	0.0	0.1	0.1	-0.2	0.1	-0.2	0.4
Progressive ratio test 2 inactive lever presses	0.8	0.9	1.2	0.7	0.9	-1.1	1.0
Incentive Sensitization - Responses	0.1	0.1	0.2	0.5	0.0	0.0	0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	0.5	0.0	0.3	0.0
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.6	0.1	0.6	-0.8	0.7
Progressive ratio	4.1	4.7	6.0	-1.6	-2.4	2.4	-2.0
Food seeking constrained by brief footshock	0.5	0.6	1.7	-1.3	-0.9	0.3	-0.2
Seeking ratio, punishment vs. effort	1.7	2.1	3.2	0.7	1.4	-1.8	1.6
Retroperitoneal fat weight	0.3	1.0	1.5	-1.2	-0.9	1.0	-0.8
Reaction time number correct	2.0	2.9	3.7	-1.7	-1.9	1.8	-1.2
Reaction time mean minus median	3.3	4.4	7.2	2.7	2.5	-1.7	1.2
Reaction time mean minus median AUC	3.2	4.2	6.7	2.2	2.6	-1.8	1.4
Reaction time num false alarms	0.4	0.6	1.5	1.2	0.4	-0.8	0.4
Reaction time num false alarms AUC	0.6	0.9	1.8	1.3	0.3	-1.0	0.6
Reaction time trials correct on left	2.0	2.9	3.7	-1.7	-1.9	1.8	-1.2
Reaction time trials on left	2.0	2.8	3.5	-1.7	-1.9	1.8	-1.2
Reaction time mean	1.8	2.5	5.4	2.0	2.3	-0.7	0.4
Reaction time mean AUC	1.5	2.1	4.7	1.8	2.2	-0.5	0.3
Median of all reaction times	0.9	1.2	2.9	1.4	1.7	0.0	-0.1
Reaction time omissions	1.2	1.7	3.8	1.9	1.7	-0.5	0.3
Reaction time false alarm rate	2.4	3.4	4.6	2.2	1.5	-2.1	1.5
Reaction time premature initiation rate	0.1	0.1	0.3	-0.3	-0.2	0.3	-0.5
Reaction time premature initiations	1.4	1.9	2.2	-1.4	-1.3	1.5	-1.4
Std. dev. reaction times	3.2	4.5	7.0	2.6	2.5	-1.8	1.2
Reaction time trials completed	2.0	2.8	3.5	-1.7	-1.9	1.8	-1.2
Reaction time trials AUC	2.0	2.9	3.6	-1.7	-1.9	1.9	-1.3
Run reversals in cocaine runway, females	0.8	0.7	2.4	-1.5	-0.7	0.2	0.1
Run reversals in cocaine runway, males	2.7	2.6	3.6	1.9	1.7	-1.5	1.3
Latency to leave start box in cocaine runway	0.2	0.2	0.4	0.5	0.7	-0.4	0.3
Latency to leave start box in cocaine runway, F	0.3	0.3	0.5	0.6	0.7	-0.5	0.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.1	-0.2	-0.1	-0.0
Std. dev. time between licks in bursts	7.2	8.7	11.3	3.4	3.0	-2.6	2.7
Total sessions with >9 infusions	0.6	0.6	1.0	0.1	0.9	-1.0	0.8
Short access day 1 total inactive lever presses	2.2	2.5	3.6	1.2	1.9	-1.2	1.9
Short access day 10 total inactive lever presses	0.6	0.7	1.1	1.0	-0.6	0.9	-0.7
Short access day 1 total infusions	2.2	2.3	4.2	0.4	1.3	-1.8	2.0
Short access day 10 total infusions	0.0	0.0	0.1	-0.2	-0.1	-0.1	0.2
Short access total infusions	0.5	0.6	1.2	-0.3	0.5	-0.9	1.1
Short access day 1 locomotion	0.5	0.5	0.6	0.7	0.7	-0.6	0.7
Short access day 10 total locomotion	1.1	1.3	2.6	1.6	1.0	-1.0	0.7
Short access total locomotion	0.2	0.2	0.3	0.6	0.5	-0.4	0.2
One hour access (0.3 mA shock)	1.1	1.3	1.6	1.2	1.3	-0.8	1.1
Compulsive drug intake	1.0	1.0	1.4	1.2	1.2	-0.2	1.1
One hour access (shock baseline)	0.4	0.4	1.0	0.3	0.7	-1.0	0.4
Social response proportion	0.1	0.1	0.1	0.4	0.2	-0.2	-0.2
Social responses	0.1	0.1	0.2	0.5	-0.2	0.0	-0.1
Social time	2.8	3.7	10.0	3.2	1.9	-0.9	0.8
Soleus weight	4.0	11.8	18.7	4.3	4.0	-2.7	2.3
Bone: stiffness	1.1	1.8	3.2	-0.8	-1.2	1.4	-1.8
Tibialis anterior weight	0.0	0.0	0.1	-0.1	-0.3	-0.2	-0.1
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.5	1.0	-0.0	1.1	-1.2
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.6	0.8	0.5	0.5	-0.3
Time to tail flick, test, before self-admin	0.2	0.2	0.7	-0.2	-0.8	0.2	-0.3
Time to tail flick, test, after self-admin	1.0	1.0	1.6	1.0	0.7	-0.9	1.3
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.5	-0.7	0.2	-0.4	0.6
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	-0.1	0.2	0.4	0.0
Tibia length	0.4	1.0	2.7	1.6	0.7	0.8	-0.5
Ambulatory time before self-admin	0.2	0.2	0.5	0.7	0.3	0.5	-0.1
Ambulatory time after self-admin	0.2	0.3	0.6	0.4	-0.4	0.8	-0.3
Bone: tissue strength	0.3	0.3	0.6	-0.8	-0.2	0.7	-0.3
Total heroin consumption	0.0	0.1	0.2	0.1	-0.2	0.4	-0.1
Bone: trabecular number	0.0	0.0	0.1	0.1	0.3	-0.2	0.1
Bone: trabecular spacing	0.5	0.7	0.8	-0.8	-0.9	0.9	-0.7
Bone: trabecular thickness	0.1	0.1	0.3	0.3	0.5	0.1	-0.2
Bone: trabecular tissue density	0.5	0.7	1.5	0.3	0.2	-1.2	1.2
Water consumed over 24 hours	0.2	0.2	0.5	0.5	0.7	-0.2	-0.1
Number of responses in last shaping day	6.3	6.5	12.1	1.1	2.1	-2.9	3.5