Hub : Genes

Hipk3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Hipk3	0.03	0.03	1.2e-04	0.02	0.02	0.02	0.02	1.9e-03	9.3e-04	2.9e-03	2.5e-03
2	pVTA	mRNA stability	Hipk3	0.06	0.05	4.2e-05	0.06	0.05	0.05	0.05	2.4e-05	7.0e-05	5.9e-05	3.9e-05
3	PL	gene expression	Hipk3	0.05	0.04	1.9e-03	0.03	0.02	0.02	0.02	9.2e-04	1.5e-03	2.1e-03	1.2e-03
4	OFC	alternative TSS	XM_008762072.4	0.14	0.12	6.1e-03	0.05	0.04	0.02	0.05	2.8e-02	4.3e-02	8.9e-02	2.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.2	0.4	0.6	-0.8	0.6	0.6	0.6
Area under the delay curve	0.3	0.3	0.4	0.5	-0.5	-0.6	-0.6
BMI with tail	0.1	0.2	0.3	0.4	0.2	-0.5	-0.5
BMI without tail	0.3	0.9	1.0	-0.9	1.0	1.0	0.9
Body weight	0.7	3.0	4.2	-1.7	2.0	1.6	1.5
Weight adjusted by age	1.6	2.4	2.9	1.3	-1.6	-1.7	-1.6
Bone surface	0.1	0.2	0.3	-0.6	0.3	0.4	0.3
Bone volume	0.4	0.7	1.0	-1.0	0.7	0.9	0.7
Breakpoint value in progressive ratio session	0.3	0.4	0.7	0.8	-0.3	-0.8	-0.4
Number of licking bursts	0.0	0.1	0.1	-0.3	-0.3	0.2	0.1
Context. condit. distance diff. score	4.9	5.9	6.7	-2.4	2.6	2.4	2.3
Locomotion velocity, session 1	0.6	0.7	1.5	0.7	-1.2	-0.3	-0.8
Locomotion distance, session 1	0.4	0.5	0.9	0.5	-0.9	-0.6	-0.5
Locomotion velocity, session 2	0.0	0.0	0.1	0.1	-0.3	-0.2	0.1
Locomotion distance, session 2	0.1	0.1	0.2	-0.3	-0.1	0.3	0.5
Locomotion velocity, session 3	0.4	0.5	0.9	0.5	-0.5	-0.8	-0.9
Locomotion distance, session 3	0.0	0.0	0.1	0.0	-0.4	-0.2	-0.1
Stereotopy head waving bouts, day 3	0.9	1.0	1.9	0.8	-0.9	-0.8	-1.4
Stereotopy head waving duration, day 3	0.1	0.1	0.1	-0.4	0.3	0.4	-0.0
Locomotion velocity, session 7	0.3	0.3	0.8	-0.5	0.4	0.5	0.9
Locomotion distance, session 7	0.0	0.0	0.2	0.1	-0.1	-0.2	0.4
Stereotopy head waving bouts, day 7	0.4	0.5	0.9	0.5	-0.6	-0.7	-0.9
Stereotopy head waving duration, day 7	0.2	0.3	0.4	0.4	-0.5	-0.4	-0.7
Locomotion velocity, session 8	0.6	0.7	1.0	-0.8	0.8	1.0	0.7
Locomotion distance, session 8	3.1	4.4	4.9	-2.2	1.9	2.1	2.2
Degree of sensitization distance	0.4	0.4	0.7	-0.3	0.7	0.7	0.8
Degree of sensitization stereotypy	0.6	0.6	0.9	0.7	-0.7	-0.7	-1.0
Conditioned locomotion	7.2	8.3	10.6	2.8	-2.7	-2.7	-3.3
Cocaine response after cond. corrected	2.8	3.3	4.0	2.0	-1.6	-1.9	-1.7
Cocaine response after cond. not corrected	0.5	0.6	0.9	0.9	-0.6	-0.8	-0.8
Cocaine response before conditioning	5.9	7.0	7.7	-2.8	2.4	2.8	2.6
Saline control response	0.1	0.1	0.3	-0.4	-0.1	0.5	0.0
Bone: connectivity density	0.2	0.4	0.6	-0.7	0.5	0.5	0.6
Bone: cortical apparent density	0.3	0.4	0.6	-0.6	0.8	0.6	0.7
Bone: cortical area	0.9	1.3	1.6	-1.2	1.0	1.2	1.1
Bone: cortical porosity	0.2	0.2	0.3	0.5	-0.4	-0.6	-0.3
Bone: cortical porosity	0.1	0.1	0.1	0.3	-0.3	-0.4	-0.1
Bone: cortical thickness	0.2	0.3	0.4	-0.6	0.3	0.6	0.5
Bone: cortical thickness	2.1	2.5	3.0	1.6	-1.4	-1.7	-1.5
Bone: cortical tissue density	0.3	0.4	0.6	-0.5	0.8	0.6	0.7
Condit. Reinf. active minus inactive responses	1.6	1.8	2.0	-1.4	1.4	1.2	1.3
Condit. Reinf. active-inactive response ratio	4.6	5.0	5.5	-2.3	2.3	2.0	2.2
Condit. Reinf. active responses	0.3	0.4	0.4	-0.7	0.4	0.7	0.7
Condit. Reinf. inactive responses	0.8	1.0	1.4	1.1	-1.2	-0.8	-0.9
Incentive salience index mean	1.4	1.7	1.9	-1.4	1.3	1.4	1.3
Condit. Reinf. lever presses	0.7	1.0	1.5	-1.0	0.8	1.2	0.9
Condit. Reinf. active minus inactive responses	1.9	2.5	2.6	-1.6	1.6	1.5	1.6
Condit. Reinf. active-inactive response ratio	5.3	6.2	6.4	-2.5	2.5	2.4	2.5
Condit. Reinf. active responses	0.9	1.3	1.6	-1.1	1.3	1.0	1.1
Condit. Reinf. inactive responses	0.4	0.5	0.7	0.6	-0.5	-0.8	-0.8
Condit. Reinf. lever presses	1.5	2.0	2.5	-1.4	1.6	1.3	1.4
Condit. Reinf. lever reinforcers received	0.8	1.1	1.3	-1.1	1.1	1.0	1.0
Conditioned reinforcement - actives	3.5	5.9	7.3	-2.6	2.3	2.7	2.1
Conditioned reinforcement - inactives	4.9	7.2	8.4	-2.9	2.6	2.7	2.5
Conditioned locomotion	0.9	1.2	1.5	-1.2	1.2	1.0	0.9
Patch foraging indifference point 0 sec	1.2	2.3	3.1	1.2	-1.3	-1.7	-1.8
Patch foraging indifference point AUC	0.4	0.6	0.8	0.9	-0.7	-0.8	-0.8
Delay disc. indifference point, 0s delay	0.1	0.2	0.3	-0.3	0.5	0.3	0.5
Delay disc. indifference point, 16s delay	1.1	1.2	1.4	1.0	-1.2	-1.2	-1.1
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	0.1	-0.1	-0.3	-0.3
Delay disc. indifference point, 24s delay	0.7	0.8	1.2	0.8	-1.1	-0.7	-1.0
Delay disc. indifference point, 4s delay	0.3	0.3	0.4	0.6	-0.4	-0.6	-0.6
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.1	0.1	0.1	0.0
Indifference point function ln k	0.5	0.9	1.0	-1.0	0.9	1.0	1.0
Indifference point function log k	0.5	0.9	1.0	-1.0	0.9	1.0	1.0
Patch foraging total patch changes 0 sec	1.1	2.1	2.9	1.2	-1.2	-1.6	-1.7
Patch foraging total patch changes 12 sec	0.0	0.0	0.0	-0.0	0.1	-0.2	-0.2
Patch foraging total patch changes 18 sec	1.0	1.5	2.5	1.0	-1.0	-1.2	-1.6
Patch foraging total patch changes 24 sec	1.4	2.5	3.5	1.4	-1.2	-1.7	-1.9
Patch foraging total patch changes 6 sec	0.9	1.4	1.8	1.0	-1.1	-1.3	-1.2
Patch foraging time to switch 0 sec	0.0	0.0	0.1	-0.2	0.3	-0.1	0.2
Patch foraging water rate 0 sec	0.0	0.0	0.1	0.2	-0.0	-0.3	-0.2
Patch foraging water rate 12 sec	0.0	0.0	0.1	0.0	0.3	0.1	0.0
Patch foraging water rate 18 sec	0.5	0.8	1.5	-1.0	0.6	1.2	0.8
Patch foraging water rate 24 sec	0.3	0.4	0.9	-0.6	0.0	1.0	0.5
Patch foraging water rate 6 sec	0.0	0.0	0.2	0.1	-0.4	-0.0	-0.0
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.0	-0.6	1.0	0.5	0.7
Distance traveled before self-admin	0.0	0.0	0.1	-0.1	-0.1	0.3	0.1
Distance traveled after self-admin	0.5	0.6	0.7	-0.8	0.7	0.8	0.6
Extensor digitorum longus weight	0.2	0.8	1.0	0.8	-1.0	-1.0	-0.7
Bone: elastic displacement	0.3	0.3	0.5	0.7	-0.3	-0.7	-0.4
Bone: elastic work	0.2	0.3	0.4	0.5	-0.1	-0.7	-0.6
Bone: endosteal estimation	0.2	0.4	0.4	0.5	-0.6	-0.6	-0.6
Bone: endosteal perimeter	0.2	0.3	0.5	-0.7	0.5	0.7	0.5
Epididymis fat weight	1.2	4.1	4.7	-2.1	2.2	1.7	2.1
Delta time in closed arm before/after self-admin	0.3	0.3	0.6	0.5	-0.6	-0.2	-0.8
Delta time in open arm before/after self-admin	0.2	0.2	0.2	0.4	-0.4	-0.5	-0.5
Diff in mean of infusions in LGA sessions	0.2	0.3	0.4	0.6	-0.3	-0.6	-0.6
Delay discount exponential model param	0.4	0.4	0.6	-0.6	0.6	0.7	0.8
Extinction: sum of active levers before priming	0.0	0.1	0.1	0.1	0.3	0.2	0.3
Active lever presses in extinction session 6	0.2	0.2	0.5	-0.3	0.7	0.1	0.4
Bone: final force	0.3	0.5	0.6	-0.8	0.7	0.8	0.7
Bone: final moment	0.2	0.4	0.4	-0.6	0.7	0.6	0.6
Food consumed during 24 hour testing period	5.5	7.6	8.7	-2.9	2.2	2.9	2.9
Glucose	3.4	5.3	5.7	-2.3	2.2	2.4	2.4
Heart weight	0.3	0.5	0.5	0.7	-0.7	-0.7	-0.7
Delay discount hyperbolic model param	0.5	0.5	0.7	-0.7	0.6	0.7	0.9
Intermittent access intake day 1-15 change	0.3	0.5	0.7	-0.8	0.8	0.6	0.6
Intermittent access intake escalation	0.4	0.9	1.3	-1.0	1.1	0.8	0.9
Intermittent access intake escalation 2	1.7	1.9	2.4	-1.3	1.5	1.4	1.3
Intermitt. access day 1 inactive lever presses	0.8	3.1	4.8	-1.6	2.2	1.0	2.1
Intermitt. access day 15 inactive lever presses	0.7	1.4	1.8	-1.2	1.3	0.9	1.3
Intermitt. access escalation Index	0.1	0.1	0.3	0.3	-0.5	0.1	-0.5
Intermittent access day 1 total infusions	1.9	3.1	3.5	-1.8	1.9	1.6	1.7
Intermittent access day 15 total infusions	2.1	3.1	3.7	-1.9	1.8	1.8	1.5
Intermittent access terminal intake (last 3 days)	2.2	2.9	3.7	-1.8	1.6	1.9	1.4
Intermittent access total infusions	2.9	3.5	3.8	-1.9	1.8	2.0	1.7
Intermittent access day 1 locomotion	1.1	1.4	1.9	-1.2	1.4	0.9	1.2
Intermittent access day 15 total locomotion	0.0	0.0	0.0	-0.1	0.1	-0.0	-0.2
Intermittent access total locomotion	0.7	0.9	1.4	-1.0	1.2	0.7	0.9
Intermittent access standard deviation	1.4	3.0	3.4	-1.8	1.6	1.8	1.6
Left kidney weight	1.2	5.5	6.3	-2.4	2.2	2.5	2.2
Right kidney weight	1.6	7.3	7.9	-2.8	2.8	2.5	2.7
Cocaine induced anxiety	0.1	0.1	0.1	-0.3	0.2	0.4	0.2
Post-drug Anxiety	0.3	0.3	0.6	0.6	-0.4	-0.8	-0.4
Baseline Anxiety	1.9	2.2	3.1	1.6	-1.3	-1.8	-1.2
Tail length	1.2	4.5	5.1	-2.1	2.0	2.3	2.2
Length with tail	1.8	7.8	8.6	-2.7	2.9	2.7	2.8
Length without tail	1.1	3.4	5.5	-1.7	2.3	1.4	1.8
Times rat made contact with spout	0.1	0.1	0.3	-0.5	0.3	0.2	0.5
Lifetime Intake	3.1	3.7	4.2	-2.0	1.8	2.1	1.9
Liver weight, left	2.9	4.8	6.4	-2.1	2.5	1.9	2.2
Liver weight, right	2.6	4.6	4.9	-2.0	2.2	2.1	2.2
Locomotor activity	0.0	0.0	0.1	0.1	0.0	-0.1	-0.4
Locomotor testing distance	1.6	3.0	4.2	-1.6	2.0	1.5	1.6
Locomotor testing rearing	0.4	0.7	1.0	-0.8	1.0	0.9	0.6
Locomotion in novel chamber	0.3	0.4	0.7	-0.6	0.8	0.5	0.6
Locomotion in novel chamber post-restriction	0.4	0.7	0.9	0.9	-0.8	-0.9	-0.7
Fecal boli incidents, locomotor time 1	2.6	3.8	4.6	2.1	-2.0	-1.8	-1.8
Change in fecal boli incidents, locomotor task	1.2	1.2	1.6	-1.3	1.1	1.0	0.9
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.2	-0.4	0.0	0.1
Bouts of movement, locomotor time 1	0.0	0.0	0.1	0.0	0.3	0.1	0.1
Total resting periods, locomotor time 1	0.0	0.0	0.1	-0.1	0.2	0.3	0.2
Rest time, locomotor task time 1	0.5	0.7	1.5	0.7	-1.2	0.2	-0.8
Distance moved, locomotor task time 1	1.3	1.9	2.8	-1.4	1.7	0.8	1.5
Vertical activity count, locomotor time 1	0.1	0.3	0.5	-0.3	0.7	-0.2	0.6
Time >=10cm from walls, locomotor time 2	3.9	5.8	6.7	-2.4	2.3	2.6	2.4
Bouts of movement, locomotor time 2	0.3	0.4	0.9	-0.5	1.0	-0.0	0.7
Total resting periods, locomotor time 2	0.3	0.5	1.1	-0.6	1.0	0.1	0.8
Rest time, locomotor task time 2	2.5	3.1	4.6	1.7	-2.1	-1.4	-1.7
Distance moved, locomotor task time 2	5.8	7.0	8.8	-2.5	3.0	2.3	2.7
Vertical activity count, locomotor time 2	3.0	4.2	5.2	-1.9	2.3	1.8	2.1
Light reinforcement 1	0.2	0.5	1.3	-0.7	0.3	1.1	0.2
Light reinforcement 2	0.2	0.3	1.1	-0.4	-0.0	1.0	0.3
Bone: marrow area	0.2	0.4	0.4	0.6	-0.6	-0.7	-0.6
Bone: maximum diameter	0.4	0.8	1.2	-0.9	0.6	1.1	0.9
Bone: maximum force	0.2	0.4	0.5	-0.7	0.6	0.6	0.4
Bone: maximum moment	0.1	0.1	0.2	-0.4	0.5	0.3	0.2
Mean time between licks in bursts	0.6	1.5	2.3	1.3	-0.9	-1.5	-1.2
Mean num. licks in bursts	0.1	0.2	0.6	-0.2	0.8	0.1	0.3
Cd content in liver	4.2	4.7	5.7	-2.1	1.7	2.4	2.4
Co content in liver	0.8	0.9	1.3	1.1	-0.8	-1.1	-0.8
Cu content in liver	0.4	0.4	0.8	0.9	-0.5	-0.7	-0.5
Fe content in liver	0.1	0.1	0.1	0.1	0.4	-0.2	0.3
K content in liver	2.7	2.6	3.7	1.6	-1.5	-1.9	-1.4
Mg content in liver	0.3	0.3	0.5	0.5	-0.5	-0.7	-0.2
Mn content in liver	0.5	0.5	0.7	0.7	-0.9	-0.6	-0.7
Na content in liver	1.0	1.1	1.9	-1.1	0.9	0.8	1.4
Rb content in liver	0.5	0.6	0.9	1.0	-0.4	-0.9	-0.6
Se content in liver	5.0	5.9	6.4	2.5	-2.1	-2.5	-2.5
Sr content in liver	0.1	0.1	0.2	0.2	-0.1	-0.4	-0.1
Zn content in liver	0.4	0.4	0.6	-0.5	0.5	0.8	0.7
Bone: minimum diameter	1.3	2.4	2.7	-1.6	1.5	1.5	1.5
Time in familiar zone, hab. session 1	0.5	0.5	0.7	0.8	-0.5	-0.7	-0.6
Time in novel zone, hab. session 1	1.0	1.0	1.4	-1.2	0.9	1.0	0.9
Total zone transitions, hab. session 1	0.8	1.1	1.6	-1.3	1.1	1.0	0.9
Total locomotion distance, hab. session 1	0.1	0.2	0.3	0.1	-0.3	-0.5	-0.5
Locomotion velocity, hab. session 1	0.2	0.3	0.5	0.3	-0.4	-0.7	-0.6
Time in familiar zone, hab. session 2	0.3	0.4	0.7	0.5	-0.9	-0.5	-0.5
Time in novel zone, hab. session 2	0.8	0.8	1.0	-0.8	1.0	0.9	0.8
Total zone transitions, hab. session 2	0.8	1.0	1.4	-1.1	0.7	1.2	0.9
Total locomotion distance, hab. session 2	0.7	0.9	1.5	0.7	-1.2	-0.7	-1.0
Locomotion velocity, hab. session 2	0.7	0.9	1.4	0.7	-1.2	-0.8	-1.0
Novel to familiar place preference ratio	1.2	1.3	1.8	-1.2	1.3	0.8	1.2
Novelty place preference	1.4	1.6	2.0	-1.3	1.4	0.9	1.4
Time in novel zone, NPP test	1.3	1.3	1.8	-1.2	1.3	0.8	1.2
Total zone transitions, NPP test	1.5	2.1	2.6	1.4	-1.6	-1.4	-1.4
Total locomotion distance, NPP test	2.6	3.5	4.4	1.8	-2.1	-1.8	-1.9
Locomotion velocity, NPP test	2.3	3.3	3.9	1.7	-2.0	-1.8	-1.7
Intraocular pressure	0.3	0.5	0.9	0.6	-1.0	-0.5	-0.7
Delta distance traveled before/after self-admin	0.1	0.2	0.3	-0.4	0.6	0.4	0.2
Delta ambulatory time before/after self-admin	0.5	0.7	1.2	-0.7	1.1	0.7	0.6
Parametrial fat weight	0.0	0.0	0.1	-0.1	-0.1	0.3	0.1
Pavlov. Cond. lever latency	0.8	1.0	1.0	1.0	-1.0	-1.0	-1.0
Pavlov. Cond. magazine entry latency	1.7	2.2	2.6	-1.5	1.6	1.6	1.3
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.1	0.3	-0.1	-0.2
Pavlov. Cond. index score	0.6	0.8	0.9	-0.8	1.0	0.9	0.8
Pavlov. Cond. latency score	0.7	0.9	1.0	-0.9	1.0	1.0	0.9
Pavlov. Cond. lever contacts	0.9	1.1	1.3	-1.0	1.1	1.1	1.0
Pavlov. Cond. magazine entry number	2.1	2.7	2.9	1.6	-1.7	-1.7	-1.5
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	0.3	-0.5	-0.6	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.7	-0.7	0.8	0.8	0.6
Pavlov. Cond. response bias	1.7	2.1	2.5	-1.4	1.6	1.5	1.3
Pavlov. Cond. lever latency	2.0	2.7	2.8	1.6	-1.7	-1.6	-1.7
Pavlov. Cond. magazine entry latency	0.7	0.8	0.9	-0.9	1.0	0.8	0.9
Pavlov. Cond. change in total contacts	0.6	1.0	1.1	-1.0	0.9	1.0	1.0
Pavlov. Cond. index score	1.9	2.6	2.8	-1.6	1.7	1.5	1.7
Pavlov. Cond. latency score	1.8	2.4	2.6	-1.6	1.5	1.5	1.6
Pavlov. Cond. lever contacts	2.6	3.7	3.8	-1.9	2.0	1.8	1.9
Pavlov. Cond. magazine entry number	0.8	1.0	1.2	1.1	-1.0	-0.9	-1.1
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.1	0.1	-0.1	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.4	2.7	-1.5	1.6	1.4	1.6
Pavlov. Cond. response bias	2.9	3.9	4.3	-2.0	2.1	1.9	2.0
Time in closed arm before self-admin	4.1	5.2	6.6	-2.4	2.6	1.9	2.2
Time in closed arm after self-admin	0.9	0.9	1.5	-1.2	1.0	1.0	0.5
Time in open arm before self-admin	5.3	5.8	6.6	2.6	-2.3	-2.4	-2.3
Time in open arm after self-admin	4.9	5.4	6.0	2.5	-2.4	-2.3	-2.1
Bone: periosteal estimation	0.0	0.0	0.0	-0.2	0.0	0.1	0.0
Bone: periosteal perimeter	0.9	1.6	2.2	-1.3	1.1	1.5	1.1
Bone: post-yield work	0.1	0.2	0.4	0.2	-0.5	-0.2	-0.6
Progressive ratio test 1 active lever presses	2.4	3.0	3.9	-1.8	1.4	2.0	1.6
Progressive ratio test 1 breakpoint	2.6	3.2	4.3	-1.9	1.5	2.1	1.7
Progressive ratio test 1 inactive lever presses	1.2	1.8	2.2	-1.5	1.3	1.4	1.2
Progressive ratio test 2 active lever presses	5.1	6.0	6.9	-2.6	2.3	2.5	2.4
Progressive ratio test 2 breakpoint	5.3	6.0	7.0	-2.6	2.3	2.5	2.3
Progressive ratio test 2 inactive lever presses	3.6	5.9	6.9	-2.5	2.6	2.1	2.4
Incentive Sensitization - Responses	3.2	4.5	4.8	-2.2	2.2	1.9	2.2
Incentive Sensitization - Breakpoint	3.1	4.0	4.4	-2.1	2.1	1.8	2.0
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.7	0.8	-0.4	-0.3	-0.4
Progressive ratio	0.6	0.9	1.1	-1.0	0.9	0.9	1.0
Food seeking constrained by brief footshock	0.3	0.4	0.5	-0.6	0.7	0.6	0.6
Seeking ratio, punishment vs. effort	0.6	0.8	1.1	0.8	-0.9	-0.8	-1.0
Retroperitoneal fat weight	12.5	53.2	59.6	-7.7	7.5	6.9	7.1
Reaction time number correct	0.0	0.0	0.1	0.2	-0.3	0.1	-0.1
Reaction time mean minus median	0.1	0.2	0.3	-0.3	0.4	0.6	0.3
Reaction time mean minus median AUC	0.1	0.3	0.4	-0.4	0.6	0.6	0.5
Reaction time num false alarms	2.4	3.4	4.4	1.8	-2.1	-1.6	-1.9
Reaction time num false alarms AUC	2.4	3.8	4.3	2.0	-2.1	-1.7	-2.0
Reaction time trials correct on left	0.0	0.0	0.1	0.2	-0.3	0.1	-0.1
Reaction time trials on left	0.0	0.1	0.1	0.2	-0.4	0.1	-0.2
Reaction time mean	0.8	1.3	1.7	-1.0	1.3	1.0	1.3
Reaction time mean AUC	1.3	2.1	2.6	-1.3	1.6	1.3	1.6
Median of all reaction times	1.4	2.0	2.6	-1.2	1.6	1.2	1.6
Reaction time omissions	0.2	0.3	0.5	0.6	-0.4	-0.7	-0.5
Reaction time false alarm rate	3.0	4.1	4.4	2.1	-2.0	-2.0	-2.1
Reaction time premature initiation rate	0.1	0.2	0.4	0.1	-0.6	0.1	-0.4
Reaction time premature initiations	0.1	0.2	0.6	0.2	-0.8	0.1	-0.5
Std. dev. reaction times	0.2	0.4	0.5	-0.5	0.7	0.6	0.6
Reaction time trials completed	0.0	0.1	0.1	0.2	-0.4	0.1	-0.2
Reaction time trials AUC	0.0	0.0	0.1	0.0	-0.2	0.2	-0.0
Run reversals in cocaine runway, females	1.3	1.3	1.9	-1.2	1.2	0.7	1.4
Run reversals in cocaine runway, males	0.9	0.9	2.0	1.0	-0.2	-1.4	-0.9
Latency to leave start box in cocaine runway	0.8	0.9	1.1	0.9	-1.0	-0.8	-0.9
Latency to leave start box in cocaine runway, F	0.3	0.4	0.5	0.7	-0.6	-0.5	-0.6
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	0.4	-0.5	-0.6	-0.4
Std. dev. time between licks in bursts	0.0	0.0	0.1	-0.1	0.0	-0.3	-0.1
Total sessions with >9 infusions	1.3	1.5	2.5	-1.3	1.0	1.6	1.0
Short access day 1 total inactive lever presses	0.7	0.9	1.0	-1.0	1.0	0.8	1.0
Short access day 10 total inactive lever presses	0.5	1.1	1.7	-0.9	1.3	0.7	1.2
Short access day 1 total infusions	3.6	4.8	5.7	-2.2	2.1	2.4	2.0
Short access day 10 total infusions	1.1	1.4	1.9	-1.3	1.0	1.4	1.0
Short access total infusions	2.4	3.1	4.1	-1.8	1.5	2.0	1.7
Short access day 1 locomotion	1.0	1.2	2.0	-1.1	1.1	1.4	0.5
Short access day 10 total locomotion	1.3	2.5	2.8	-1.6	1.7	1.6	1.4
Short access total locomotion	1.5	1.8	2.1	-1.4	1.4	1.5	1.1
One hour access (0.3 mA shock)	3.8	4.3	4.7	-2.1	2.2	2.1	1.9
Compulsive drug intake	3.2	3.8	4.9	2.1	-1.8	-2.2	-1.7
One hour access (shock baseline)	5.1	7.7	9.2	-2.9	2.8	3.0	2.4
Social response proportion	2.0	2.3	3.0	1.7	-1.7	-1.4	-1.2
Social responses	0.2	0.2	0.8	-0.3	-0.1	0.9	0.4
Social time	2.6	3.5	4.3	2.1	-1.8	-1.8	-1.7
Soleus weight	0.9	2.6	4.2	1.6	-1.3	-2.0	-1.4
Bone: stiffness	0.7	1.2	1.6	-1.2	0.7	1.3	1.0
Tibialis anterior weight	1.8	6.1	6.4	2.5	-2.4	-2.5	-2.5
Time to tail flick, vehicle, before self-admin	0.8	0.9	1.4	-0.8	1.2	0.9	0.8
Time to tail flick, vehicle, after self-admin	2.3	3.1	3.7	-1.9	1.6	1.8	1.7
Time to tail flick, test, before self-admin	1.6	1.7	2.4	-1.3	1.6	1.2	1.2
Time to tail flick, test, after self-admin	2.4	2.5	3.0	-1.7	1.4	1.7	1.6
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.4	-0.6	0.4	0.4	0.7
Delta time to tail flick, test, before/after SA	0.2	0.2	0.6	0.3	-0.8	-0.1	-0.3
Tibia length	0.0	0.1	0.1	-0.1	0.3	0.2	0.3
Ambulatory time before self-admin	0.0	0.0	0.0	-0.0	-0.2	0.2	0.0
Ambulatory time after self-admin	1.6	1.9	2.8	-1.3	1.3	1.7	1.1
Bone: tissue strength	0.4	0.4	0.5	0.6	-0.7	-0.4	-0.7
Total heroin consumption	0.1	0.1	0.3	0.5	-0.2	-0.4	-0.2
Bone: trabecular number	0.2	0.4	0.6	-0.8	0.6	0.6	0.5
Bone: trabecular spacing	0.1	0.1	0.3	-0.3	0.1	0.6	0.3
Bone: trabecular thickness	0.4	0.5	0.7	-0.8	0.6	0.7	0.8
Bone: trabecular tissue density	0.3	0.4	0.8	0.8	-0.4	-0.9	-0.3
Water consumed over 24 hours	0.8	1.1	1.3	-1.2	1.0	1.0	1.1
Number of responses in last shaping day	4.6	5.0	5.6	-2.4	2.2	2.3	2.1