Hub : Genes

Hipk3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Hipk3	0.02	0.02	1.4e-03	0.01	0.02	0.01	0.01	1.1e-02	6.5e-03	1.0e-02	1.5e-02
2	Brain	mRNA stability	Hipk3	0.03	0.03	1.1e-03	0.02	0.02	0.02	-0	4.4e-03	5.4e-03	5.7e-03	4.8e-01
3	pVTA	alternative TSS	NM_031787.2	0.05	0.04	7.2e-03	0.04	0.02	0.02	0.03	1.2e-02	4.7e-02	5.2e-02	2.1e-02
4	pVTA	alternative TSS	NM_031787.2	0.05	0.04	4.9e-03	0.04	0.03	0.03	0.03	7.2e-03	2.5e-02	1.5e-02	1.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.3	0.5	0.7	-0.8	-0.8	0.6	0.6
Area under the delay curve	0.5	0.5	0.7	0.8	0.8	-0.7	-0.7
BMI with tail	0.1	0.3	0.4	-0.6	-0.6	0.5	0.5
BMI without tail	0.3	0.7	0.9	-0.9	-0.8	0.8	0.8
Body weight	0.8	3.6	3.9	-2.0	-1.9	1.8	1.8
Weight adjusted by age	0.8	1.0	1.1	1.1	0.9	-1.0	-1.0
Bone surface	0.2	0.3	0.4	-0.6	-0.6	0.5	0.5
Bone volume	0.5	0.9	1.1	-1.1	-0.9	0.9	0.9
Breakpoint value in progressive ratio session	0.1	0.2	0.4	0.6	0.2	-0.3	-0.3
Number of licking bursts	0.0	0.0	0.1	-0.3	0.1	0.1	0.1
Context. condit. distance diff. score	4.6	5.6	6.0	-2.4	-2.3	2.3	2.3
Locomotion velocity, session 1	0.4	0.4	0.8	0.7	0.9	-0.5	-0.5
Locomotion distance, session 1	0.3	0.4	0.5	0.5	0.5	-0.7	-0.7
Locomotion velocity, session 2	0.1	0.1	0.1	0.1	0.0	-0.3	-0.3
Locomotion distance, session 2	0.1	0.1	0.4	-0.4	-0.6	0.2	0.2
Locomotion velocity, session 3	0.5	0.6	0.8	0.5	0.7	-0.9	-0.9
Locomotion distance, session 3	0.0	0.0	0.0	0.0	-0.1	-0.2	-0.2
Stereotopy head waving bouts, day 3	0.8	0.9	1.6	0.8	1.3	-0.8	-0.8
Stereotopy head waving duration, day 3	0.1	0.2	0.2	-0.4	-0.1	0.5	0.5
Locomotion velocity, session 7	0.3	0.3	0.6	-0.5	-0.8	0.5	0.5
Locomotion distance, session 7	0.0	0.1	0.2	0.1	-0.4	-0.1	-0.1
Stereotopy head waving bouts, day 7	0.3	0.4	0.7	0.5	0.8	-0.6	-0.6
Stereotopy head waving duration, day 7	0.2	0.3	0.5	0.4	0.7	-0.4	-0.4
Locomotion velocity, session 8	0.7	0.8	0.9	-0.9	-0.9	0.9	0.9
Locomotion distance, session 8	3.3	4.9	5.5	-2.3	-2.3	2.1	2.1
Degree of sensitization distance	0.5	0.5	0.6	-0.4	-0.8	0.7	0.7
Degree of sensitization stereotypy	0.7	0.7	1.1	0.8	1.0	-0.8	-0.8
Conditioned locomotion	6.8	8.0	10.2	2.8	3.2	-2.6	-2.6
Cocaine response after cond. corrected	3.0	3.4	3.7	1.9	1.8	-1.8	-1.8
Cocaine response after cond. not corrected	0.5	0.6	0.7	0.8	0.7	-0.7	-0.7
Cocaine response before conditioning	6.3	7.6	7.9	-2.8	-2.8	2.7	2.7
Saline control response	0.1	0.1	0.2	-0.3	-0.2	0.5	0.5
Bone: connectivity density	0.4	0.6	0.8	-0.9	-0.9	0.7	0.7
Bone: cortical apparent density	0.1	0.2	0.2	-0.3	-0.4	0.4	0.4
Bone: cortical area	0.9	1.4	1.5	-1.2	-1.1	1.2	1.2
Bone: cortical porosity	0.6	0.6	0.7	0.8	0.6	-0.8	-0.8
Bone: cortical porosity	0.1	0.1	0.1	0.3	0.1	-0.4	-0.4
Bone: cortical thickness	0.2	0.4	0.4	-0.6	-0.5	0.6	0.6
Bone: cortical thickness	1.9	2.2	2.3	1.4	1.4	-1.5	-1.5
Bone: cortical tissue density	0.1	0.2	0.2	-0.3	-0.4	0.5	0.5
Condit. Reinf. active minus inactive responses	1.3	1.5	2.2	-1.3	-1.5	1.0	1.0
Condit. Reinf. active-inactive response ratio	3.8	4.1	5.0	-2.2	-2.2	1.8	1.8
Condit. Reinf. active responses	0.3	0.4	0.8	-0.6	-0.9	0.4	0.4
Condit. Reinf. inactive responses	0.8	0.9	1.1	1.0	0.9	-0.9	-0.9
Incentive salience index mean	1.3	1.5	2.1	-1.3	-1.5	1.1	1.1
Condit. Reinf. lever presses	1.0	1.3	1.5	-1.1	-1.2	1.1	1.1
Condit. Reinf. active minus inactive responses	2.3	2.8	3.0	-1.7	-1.7	1.7	1.7
Condit. Reinf. active-inactive response ratio	6.1	6.3	6.5	-2.6	-2.5	2.5	2.5
Condit. Reinf. active responses	1.1	1.5	1.7	-1.3	-1.3	1.1	1.1
Condit. Reinf. inactive responses	0.3	0.3	0.4	0.5	0.5	-0.7	-0.7
Condit. Reinf. lever presses	1.2	1.6	1.8	-1.3	-1.3	1.2	1.2
Condit. Reinf. lever reinforcers received	1.0	1.4	1.6	-1.3	-1.2	1.1	1.1
Conditioned reinforcement - actives	5.6	5.6	5.8	-2.4	-2.2	2.4	2.4
Conditioned reinforcement - inactives	8.8	9.9	10.9	-3.3	-3.0	3.1	3.1
Conditioned locomotion	1.4	1.7	1.9	-1.4	-1.2	1.3	1.3
Patch foraging indifference point 0 sec	1.7	2.8	3.2	1.4	1.8	-1.7	-1.7
Patch foraging indifference point AUC	0.6	0.7	0.8	0.9	0.8	-0.8	-0.8
Delay disc. indifference point, 0s delay	0.1	0.1	0.4	-0.2	-0.6	0.3	0.3
Delay disc. indifference point, 16s delay	1.2	1.2	1.6	1.1	1.3	-1.0	-1.0
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	0.1	0.1	-0.3	-0.3
Delay disc. indifference point, 24s delay	0.7	0.7	1.6	0.8	1.3	-0.5	-0.5
Delay disc. indifference point, 4s delay	0.3	0.4	0.5	0.6	0.4	-0.7	-0.7
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	0.0	0.0	0.2	0.2
Indifference point function ln k	0.7	0.9	1.2	-1.0	-1.1	0.9	0.9
Indifference point function log k	0.7	0.9	1.2	-1.0	-1.1	0.9	0.9
Patch foraging total patch changes 0 sec	1.7	2.7	3.0	1.4	1.7	-1.7	-1.7
Patch foraging total patch changes 12 sec	0.0	0.0	0.0	-0.1	0.1	0.0	0.0
Patch foraging total patch changes 18 sec	1.0	1.3	1.4	1.0	1.2	-1.1	-1.1
Patch foraging total patch changes 24 sec	2.1	2.6	2.8	1.4	1.7	-1.6	-1.6
Patch foraging total patch changes 6 sec	1.0	1.5	1.7	1.1	1.2	-1.3	-1.3
Patch foraging time to switch 0 sec	0.0	0.0	0.0	-0.1	-0.2	-0.1	-0.1
Patch foraging water rate 0 sec	0.0	0.0	0.1	0.2	0.1	-0.0	-0.0
Patch foraging water rate 12 sec	0.0	0.0	0.1	-0.1	-0.3	0.1	0.1
Patch foraging water rate 18 sec	0.5	0.7	1.0	-1.0	-0.8	0.8	0.8
Patch foraging water rate 24 sec	0.5	0.7	1.0	-0.7	-0.7	1.0	1.0
Patch foraging water rate 6 sec	0.0	0.0	0.0	0.0	-0.2	0.2	0.2
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	0.7	-0.7	-0.6	0.8	0.8
Distance traveled before self-admin	0.8	0.8	0.9	-0.9	-0.8	1.0	1.0
Distance traveled after self-admin	1.8	2.0	2.7	-1.4	-1.6	1.3	1.3
Extensor digitorum longus weight	0.2	0.7	0.9	0.8	0.5	-1.0	-1.0
Bone: elastic displacement	0.5	0.5	0.6	0.7	0.5	-0.8	-0.8
Bone: elastic work	0.3	0.4	0.5	0.5	0.5	-0.7	-0.7
Bone: endosteal estimation	0.2	0.4	0.4	0.6	0.7	-0.6	-0.6
Bone: endosteal perimeter	0.2	0.4	0.5	-0.6	-0.4	0.7	0.7
Epididymis fat weight	0.8	1.9	2.3	-1.5	-1.5	1.2	1.2
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	0.0	0.1	-0.0	-0.0
Delta time in open arm before/after self-admin	1.5	1.5	1.7	1.2	1.3	-1.2	-1.2
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	-0.3	-0.2	0.1	0.1
Delay discount exponential model param	0.7	0.8	0.9	-0.9	-1.0	0.8	0.8
Extinction: sum of active levers before priming	0.9	0.9	1.0	-0.7	-1.0	1.0	1.0
Active lever presses in extinction session 6	0.7	0.7	1.1	-0.7	-1.0	0.8	0.8
Bone: final force	0.4	0.6	0.7	-0.7	-0.7	0.9	0.9
Bone: final moment	0.2	0.3	0.3	-0.4	-0.6	0.6	0.6
Food consumed during 24 hour testing period	7.3	8.9	9.1	-2.9	-2.9	3.0	3.0
Glucose	2.8	4.3	4.6	-2.0	-2.0	2.1	2.1
Heart weight	0.0	0.0	0.1	0.2	0.4	0.0	0.0
Delay discount hyperbolic model param	0.5	0.5	0.6	-0.7	-0.8	0.7	0.7
Intermittent access intake day 1-15 change	0.1	0.1	0.2	-0.4	-0.4	0.3	0.3
Intermittent access intake escalation	0.3	0.3	0.3	-0.6	-0.5	0.5	0.5
Intermittent access intake escalation 2	2.0	2.0	2.1	-1.4	-1.4	1.4	1.4
Intermitt. access day 1 inactive lever presses	2.4	2.6	4.1	-1.4	-2.0	1.5	1.5
Intermitt. access day 15 inactive lever presses	4.7	5.2	5.9	-2.2	-2.4	2.2	2.2
Intermitt. access escalation Index	0.0	0.0	0.1	-0.2	0.0	0.2	0.2
Intermittent access day 1 total infusions	1.9	2.1	2.4	-1.5	-1.2	1.5	1.5
Intermittent access day 15 total infusions	2.9	3.3	3.6	-1.9	-1.5	1.9	1.9
Intermittent access terminal intake (last 3 days)	3.7	4.0	4.6	-2.1	-1.5	2.2	2.2
Intermittent access total infusions	3.8	4.3	4.8	-2.2	-1.7	2.2	2.2
Intermittent access day 1 locomotion	0.6	0.6	0.7	-0.8	-0.8	0.8	0.8
Intermittent access day 15 total locomotion	0.0	0.0	0.0	-0.2	0.1	0.1	0.1
Intermittent access total locomotion	0.5	0.5	0.7	-0.8	-0.8	0.6	0.6
Intermittent access standard deviation	3.4	3.6	4.0	-2.0	-1.6	2.0	2.0
Left kidney weight	1.3	3.7	3.9	-2.0	-1.8	2.0	2.0
Right kidney weight	0.9	2.5	2.6	-1.6	-1.6	1.6	1.6
Cocaine induced anxiety	1.8	2.0	2.2	-1.5	-1.4	1.4	1.4
Post-drug Anxiety	0.2	0.2	0.3	-0.4	-0.6	0.3	0.3
Baseline Anxiety	5.5	5.8	6.4	2.4	2.2	-2.5	-2.5
Tail length	0.8	2.3	2.4	-1.5	-1.5	1.5	1.5
Length with tail	0.8	2.8	3.0	-1.7	-1.6	1.7	1.7
Length without tail	0.4	1.0	1.1	-1.0	-1.0	0.9	0.9
Times rat made contact with spout	0.1	0.1	0.3	-0.4	-0.6	0.2	0.2
Lifetime Intake	4.4	4.9	5.7	-2.3	-1.8	2.4	2.4
Liver weight, left	1.6	2.5	3.7	-1.5	-1.9	1.4	1.4
Liver weight, right	3.6	6.1	6.2	-2.4	-2.5	2.5	2.5
Locomotor activity	0.0	0.0	0.1	0.1	0.2	-0.3	-0.3
Locomotor testing distance	1.1	1.8	2.3	-1.5	-1.5	1.1	1.1
Locomotor testing rearing	0.4	0.6	0.7	-0.8	-0.6	0.8	0.8
Locomotion in novel chamber	0.1	0.1	0.3	-0.2	-0.5	0.2	0.2
Locomotion in novel chamber post-restriction	1.0	1.2	1.4	1.2	0.9	-1.2	-1.2
Fecal boli incidents, locomotor time 1	4.1	4.5	4.9	2.2	2.2	-2.1	-2.1
Change in fecal boli incidents, locomotor task	1.4	1.3	1.4	-1.2	-1.1	1.1	1.1
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.1	0.4	0.2	0.2
Bouts of movement, locomotor time 1	0.0	0.0	0.0	0.1	-0.2	-0.0	-0.0
Total resting periods, locomotor time 1	0.0	0.0	0.0	0.0	-0.1	0.1	0.1
Rest time, locomotor task time 1	0.1	0.2	0.5	0.3	0.7	0.2	0.2
Distance moved, locomotor task time 1	1.7	1.9	2.8	-1.4	-1.7	1.2	1.2
Vertical activity count, locomotor time 1	0.1	0.1	0.3	-0.2	-0.5	0.0	0.0
Time >=10cm from walls, locomotor time 2	5.8	6.1	6.8	-2.5	-2.2	2.6	2.6
Bouts of movement, locomotor time 2	0.5	0.6	1.4	-0.6	-1.2	0.5	0.5
Total resting periods, locomotor time 2	0.5	0.6	1.5	-0.6	-1.2	0.4	0.4
Rest time, locomotor task time 2	2.6	3.0	4.3	1.7	2.1	-1.6	-1.6
Distance moved, locomotor task time 2	6.2	7.2	8.9	-2.5	-3.0	2.6	2.6
Vertical activity count, locomotor time 2	4.2	4.6	5.3	-2.0	-2.3	2.1	2.1
Light reinforcement 1	0.4	0.6	1.0	-0.7	-0.3	1.0	1.0
Light reinforcement 2	0.1	0.2	0.3	-0.4	-0.2	0.5	0.5
Bone: marrow area	0.2	0.4	0.4	0.7	0.7	-0.6	-0.6
Bone: maximum diameter	0.6	1.1	1.3	-1.0	-1.0	1.1	1.1
Bone: maximum force	0.1	0.1	0.2	-0.4	-0.3	0.4	0.4
Bone: maximum moment	0.0	0.0	0.0	-0.1	-0.0	-0.0	-0.0
Mean time between licks in bursts	1.3	1.9	2.0	1.3	1.4	-1.4	-1.4
Mean num. licks in bursts	0.1	0.1	0.3	-0.1	-0.6	0.2	0.2
Cd content in liver	0.7	0.7	0.9	-0.8	-0.7	0.9	0.9
Co content in liver	1.8	2.1	2.3	1.4	1.3	-1.5	-1.5
Cu content in liver	0.2	0.2	0.4	0.6	0.4	-0.5	-0.5
Fe content in liver	0.2	0.3	0.4	0.5	0.2	-0.6	-0.6
K content in liver	1.9	1.9	2.2	1.3	1.1	-1.5	-1.5
Mg content in liver	1.0	1.0	1.2	1.0	0.7	-1.1	-1.1
Mn content in liver	0.8	1.0	1.2	1.1	1.0	-0.9	-0.9
Na content in liver	0.1	0.1	0.3	-0.4	-0.6	0.2	0.2
Rb content in liver	0.8	1.0	1.3	1.0	0.7	-1.1	-1.1
Se content in liver	4.6	5.6	5.9	2.4	2.3	-2.4	-2.4
Sr content in liver	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1
Zn content in liver	0.1	0.1	0.2	0.5	0.4	-0.2	-0.2
Bone: minimum diameter	1.2	2.2	2.5	-1.5	-1.6	1.4	1.4
Time in familiar zone, hab. session 1	0.7	0.6	0.7	0.8	0.8	-0.8	-0.8
Time in novel zone, hab. session 1	1.2	1.2	1.3	-1.1	-1.0	1.1	1.1
Total zone transitions, hab. session 1	0.8	1.1	1.4	-1.2	-1.1	0.9	0.9
Total locomotion distance, hab. session 1	0.1	0.2	0.2	0.2	0.4	-0.5	-0.5
Locomotion velocity, hab. session 1	0.3	0.4	0.5	0.4	0.5	-0.7	-0.7
Time in familiar zone, hab. session 2	0.3	0.3	0.4	0.6	0.6	-0.5	-0.5
Time in novel zone, hab. session 2	0.8	0.8	0.9	-0.9	-0.8	1.0	1.0
Total zone transitions, hab. session 2	0.9	1.2	1.3	-1.1	-1.0	1.1	1.1
Total locomotion distance, hab. session 2	0.4	0.6	0.9	0.7	1.0	-0.7	-0.7
Locomotion velocity, hab. session 2	0.5	0.7	1.0	0.8	1.0	-0.8	-0.8
Novel to familiar place preference ratio	1.0	1.0	1.3	-1.1	-1.1	0.9	0.9
Novelty place preference	1.2	1.3	1.6	-1.2	-1.2	1.0	1.0
Time in novel zone, NPP test	1.1	1.1	1.4	-1.2	-1.2	1.0	1.0
Total zone transitions, NPP test	1.5	2.2	2.2	1.4	1.4	-1.5	-1.5
Total locomotion distance, NPP test	2.3	3.1	3.5	1.8	1.9	-1.7	-1.7
Locomotion velocity, NPP test	2.1	3.0	3.1	1.7	1.8	-1.7	-1.7
Intraocular pressure	0.3	0.4	0.7	0.5	0.9	-0.6	-0.6
Delta distance traveled before/after self-admin	0.0	0.0	0.1	-0.2	-0.3	0.0	0.0
Delta ambulatory time before/after self-admin	0.2	0.2	0.5	-0.5	-0.7	0.4	0.4
Parametrial fat weight	0.6	1.1	1.3	-0.9	-0.9	1.2	1.2
Pavlov. Cond. lever latency	0.3	0.3	0.4	0.7	0.7	-0.5	-0.5
Pavlov. Cond. magazine entry latency	1.7	2.1	2.3	-1.5	-1.3	1.5	1.5
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.3	0.4	-0.4	-0.4
Pavlov. Cond. index score	0.3	0.4	0.5	-0.7	-0.7	0.5	0.5
Pavlov. Cond. latency score	0.3	0.4	0.5	-0.7	-0.7	0.6	0.6
Pavlov. Cond. lever contacts	0.4	0.5	0.7	-0.7	-0.8	0.6	0.6
Pavlov. Cond. magazine entry number	1.6	2.0	2.2	1.5	1.4	-1.4	-1.4
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.3	-0.2	-0.5	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.3	-0.5	-0.5	0.4	0.4
Pavlov. Cond. response bias	1.4	1.7	1.9	-1.3	-1.4	1.3	1.3
Pavlov. Cond. lever latency	2.5	3.4	3.5	1.8	1.8	-1.9	-1.9
Pavlov. Cond. magazine entry latency	0.7	0.8	0.9	-1.0	-0.8	0.9	0.9
Pavlov. Cond. change in total contacts	0.9	1.3	1.5	-1.0	-1.0	1.2	1.2
Pavlov. Cond. index score	1.9	2.4	2.4	-1.5	-1.6	1.5	1.5
Pavlov. Cond. latency score	1.9	2.3	2.4	-1.5	-1.5	1.5	1.5
Pavlov. Cond. lever contacts	2.7	3.6	4.0	-1.9	-2.0	1.9	1.9
Pavlov. Cond. magazine entry number	0.5	0.6	0.6	0.8	0.7	-0.7	-0.7
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.2	-0.1	-0.4	0.0	0.0
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.2	2.3	-1.5	-1.5	1.5	1.5
Pavlov. Cond. response bias	2.6	3.6	3.8	-1.9	-2.0	1.9	1.9
Time in closed arm before self-admin	3.6	4.1	5.7	-2.1	-2.4	1.8	1.8
Time in closed arm after self-admin	1.4	1.4	1.7	-1.3	-1.2	1.1	1.1
Time in open arm before self-admin	2.8	3.0	3.5	1.8	1.9	-1.7	-1.7
Time in open arm after self-admin	6.6	7.2	8.1	2.7	2.9	-2.6	-2.6
Bone: periosteal estimation	0.0	0.0	0.1	-0.2	-0.1	0.3	0.3
Bone: periosteal perimeter	1.0	1.6	1.9	-1.2	-1.1	1.4	1.4
Bone: post-yield work	0.2	0.3	0.5	0.4	0.7	-0.4	-0.4
Progressive ratio test 1 active lever presses	2.7	2.8	3.2	-1.8	-1.4	1.8	1.8
Progressive ratio test 1 breakpoint	2.7	2.8	3.4	-1.8	-1.2	1.8	1.8
Progressive ratio test 1 inactive lever presses	2.9	3.2	3.4	-1.8	-1.7	1.8	1.8
Progressive ratio test 2 active lever presses	2.4	2.5	2.9	-1.7	-1.2	1.7	1.7
Progressive ratio test 2 breakpoint	3.0	3.4	3.7	-1.9	-1.5	1.9	1.9
Progressive ratio test 2 inactive lever presses	4.9	5.6	6.0	-2.3	-2.3	2.4	2.4
Incentive Sensitization - Responses	1.8	1.8	1.9	-1.2	-1.4	1.4	1.4
Incentive Sensitization - Breakpoint	1.4	1.4	1.5	-1.1	-1.2	1.2	1.2
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.2	-0.3	0.1	0.1
Progressive ratio	0.6	0.7	0.9	-0.8	-0.9	0.8	0.8
Food seeking constrained by brief footshock	0.5	0.6	0.6	-0.8	-0.7	0.8	0.8
Seeking ratio, punishment vs. effort	0.8	1.0	1.4	0.9	1.2	-1.0	-1.0
Retroperitoneal fat weight	9.3	30.5	33.2	-5.8	-5.6	5.4	5.4
Reaction time number correct	0.0	0.1	0.1	-0.0	0.1	0.4	0.4
Reaction time mean minus median	0.0	0.1	0.1	-0.3	-0.2	0.2	0.2
Reaction time mean minus median AUC	0.1	0.1	0.2	-0.3	-0.3	0.4	0.4
Reaction time num false alarms	2.6	3.6	4.2	1.7	2.0	-1.9	-1.9
Reaction time num false alarms AUC	2.9	4.0	4.6	1.9	2.1	-2.0	-2.0
Reaction time trials correct on left	0.0	0.1	0.1	-0.0	0.1	0.4	0.4
Reaction time trials on left	0.0	0.0	0.1	0.1	0.2	0.3	0.3
Reaction time mean	0.6	0.8	1.4	-0.9	-1.2	0.8	0.8
Reaction time mean AUC	1.0	1.4	2.1	-1.1	-1.4	1.0	1.0
Median of all reaction times	1.1	1.6	2.3	-1.2	-1.5	1.1	1.1
Reaction time omissions	0.8	1.1	1.4	0.9	1.2	-1.0	-1.0
Reaction time false alarm rate	3.8	5.3	5.8	2.1	2.3	-2.4	-2.4
Reaction time premature initiation rate	0.1	0.1	0.1	0.1	0.4	-0.3	-0.3
Reaction time premature initiations	0.0	0.0	0.1	0.1	0.4	-0.0	-0.0
Std. dev. reaction times	0.1	0.1	0.2	-0.3	-0.4	0.2	0.2
Reaction time trials completed	0.0	0.0	0.1	0.1	0.2	0.3	0.3
Reaction time trials AUC	0.1	0.1	0.2	-0.1	-0.1	0.5	0.5
Run reversals in cocaine runway, females	1.3	1.2	1.9	-1.1	-1.4	0.9	0.9
Run reversals in cocaine runway, males	1.7	1.7	2.3	1.3	0.6	-1.5	-1.5
Latency to leave start box in cocaine runway	0.5	0.5	0.5	0.7	0.7	-0.7	-0.7
Latency to leave start box in cocaine runway, F	0.4	0.4	0.5	0.7	0.6	-0.7	-0.7
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1
Std. dev. time between licks in bursts	0.0	0.0	0.0	-0.0	0.2	-0.1	-0.1
Total sessions with >9 infusions	2.5	2.7	2.9	-1.6	-1.6	1.7	1.7
Short access day 1 total inactive lever presses	0.7	0.8	1.0	-0.7	-0.8	1.0	1.0
Short access day 10 total inactive lever presses	1.5	1.7	2.4	-1.2	-1.5	1.2	1.2
Short access day 1 total infusions	7.8	8.3	9.5	-2.9	-2.5	3.1	3.1
Short access day 10 total infusions	1.1	1.2	1.5	-1.2	-0.8	1.2	1.2
Short access total infusions	3.7	4.1	4.9	-2.0	-1.7	2.2	2.2
Short access day 1 locomotion	0.7	0.7	0.9	-1.0	-0.6	0.9	0.9
Short access day 10 total locomotion	1.3	1.5	1.6	-1.3	-1.2	1.2	1.2
Short access total locomotion	1.0	1.0	1.2	-1.1	-0.9	1.0	1.0
One hour access (0.3 mA shock)	2.3	2.7	3.1	-1.8	-1.7	1.6	1.6
Compulsive drug intake	1.3	1.3	1.4	1.2	1.0	-1.2	-1.2
One hour access (shock baseline)	4.0	4.6	5.4	-2.3	-2.0	2.1	2.1
Social response proportion	1.8	1.9	2.7	1.6	1.5	-1.2	-1.2
Social responses	0.2	0.2	0.4	-0.3	-0.1	0.6	0.6
Social time	2.9	3.8	4.7	2.2	2.0	-1.8	-1.8
Soleus weight	1.1	3.2	3.7	1.8	1.5	-1.9	-1.9
Bone: stiffness	0.6	1.0	1.1	-1.0	-0.8	1.1	1.1
Tibialis anterior weight	1.7	5.9	6.2	2.5	2.3	-2.5	-2.5
Time to tail flick, vehicle, before self-admin	0.7	0.8	1.1	-0.9	-1.1	0.7	0.7
Time to tail flick, vehicle, after self-admin	1.9	2.0	3.0	-1.7	-1.4	1.3	1.3
Time to tail flick, test, before self-admin	0.5	0.5	0.6	-0.8	-0.8	0.6	0.6
Time to tail flick, test, after self-admin	1.0	1.0	1.2	-1.0	-0.9	1.1	1.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	-0.6	-0.3	0.3	0.3
Delta time to tail flick, test, before/after SA	0.2	0.1	0.3	0.4	0.6	-0.2	-0.2
Tibia length	0.0	0.1	0.3	-0.3	-0.5	0.2	0.2
Ambulatory time before self-admin	0.8	0.8	0.9	-0.8	-1.0	0.9	0.9
Ambulatory time after self-admin	2.9	3.2	4.1	-1.8	-2.0	1.6	1.6
Bone: tissue strength	0.5	0.5	0.7	0.7	0.8	-0.6	-0.6
Total heroin consumption	0.2	0.3	0.4	0.6	0.5	-0.5	-0.5
Bone: trabecular number	0.4	0.6	0.7	-0.8	-0.8	0.7	0.7
Bone: trabecular spacing	0.1	0.1	0.2	-0.3	-0.1	0.4	0.4
Bone: trabecular thickness	0.3	0.4	0.6	-0.6	-0.8	0.5	0.5
Bone: trabecular tissue density	0.9	1.3	1.6	1.1	0.7	-1.3	-1.3
Water consumed over 24 hours	0.5	0.6	0.6	-0.8	-0.8	0.8	0.8
Number of responses in last shaping day	2.6	2.7	2.9	-1.7	-1.5	1.7	1.7