Hub : Genes

Hexb

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Hexb 0.41 0.12 0.0e+00 0.3 0.31 0.34 0.34 4.2e-34 1.2e-34 1.5e-38 2.5e-38
2 Eye mRNA stability Hexb 0.21 0.14 5.1e-03 0.14 0.01 0.14 0.1 4.1e-03 2.5e-01 4.0e-03 1.2e-02
3 Liver mRNA stability Hexb 0.56 0.13 0.0e+00 0.36 0.35 0.37 0.37 5.8e-42 8.1e-40 3.1e-43 5.7e-43
4 Adipose mRNA stability Hexb 0.29 0.1 0.0e+00 0.19 0.2 0.2 0.2 1.3e-20 3.0e-21 1.7e-21 1.9e-21
5 NAcc mRNA stability Hexb 0.36 0.11 0.0e+00 0.39 0.39 0.4 0.4 4.8e-63 1.5e-63 4.5e-65 2.1e-64
6 pVTA mRNA stability Hexb 0.18 0.09 0.0e+00 0.23 0.22 0.24 0.24 7.2e-19 1.2e-17 6.6e-19 3.8e-19
7 IC gene expression Hexb 0.29 0.14 2.1e-11 0.21 0.25 0.25 0.25 2.9e-09 7.0e-11 1.0e-10 6.7e-11
8 Adipose gene expression Hexb 0.1 0.05 1.6e-11 0.08 0.08 0.08 0.08 5.0e-09 2.1e-09 2.0e-09 2.1e-09
9 IL gene expression Hexb 0.36 0.14 1.9e-09 0.35 0.26 0.33 0.07 2.7e-09 7.7e-07 7.7e-09 8.5e-03
10 BLA gene expression Hexb 0.19 0.08 3.3e-15 0.27 0.28 0.28 0.28 1.8e-14 4.0e-15 5.2e-15 4.4e-15
11 Eye gene expression Hexb 0.73 0.13 1.1e-10 0.49 0.17 0.48 0.47 5.5e-09 1.4e-03 9.5e-09 1.0e-08
12 pVTA gene expression Hexb 0.28 0.13 2.2e-16 0.2 0.19 0.19 0.2 1.3e-15 2.4e-15 3.2e-15 1.0e-15
13 PL gene expression Hexb 0.18 0.08 0.0e+00 0.27 0.27 0.27 0.28 5.4e-30 5.6e-29 3.3e-29 2.7e-30
14 IC mRNA stability Hexb 0.37 0.13 0.0e+00 0.44 0.41 0.41 0.41 3.4e-20 2.1e-18 1.2e-18 1.0e-18
15 PL mRNA stability Hexb 0.08 0.05 1.5e-09 0.08 0.08 0.08 0.08 2.5e-09 1.2e-08 4.7e-09 3.0e-09
16 OFC gene expression Hexb 0.38 0.23 2.2e-05 0.2 0.15 0.15 0.17 2.2e-05 1.9e-04 2.2e-04 6.4e-05
17 NAcc gene expression Hexb 0.18 0.1 0.0e+00 0.21 0.19 0.19 0.2 2.3e-31 1.2e-27 2.4e-28 2.6e-30
18 BLA mRNA stability Hexb 0.33 0.11 0.0e+00 0.42 0.45 0.44 0.45 3.3e-24 4.8e-26 1.9e-25 5.1e-26
19 Brain gene expression Hexb 0.64 0.11 0.0e+00 0.59 0.6 0.61 0.6 3.4e-68 2.6e-70 3.6e-71 9.8e-70
20 RMTg gene expression Hexb 0.33 0.15 7.5e-05 0.16 0.17 0.16 0.19 3.9e-05 2.4e-05 4.3e-05 8.7e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Bone: apparent density0.10.10.30.30.30.30.30.20.50.50.10.50.30.50.50.10.60.60.60.20.20.20.3
Area under the delay curve0.40.50.8-0.9-0.8-0.9-0.8-0.8-0.7-0.7-0.7-0.5-0.8-0.5-0.6-0.7-0.6-0.6-0.6-0.7-0.9-0.7-0.5
BMI with tail1.65.46.7-2.6-2.5-2.4-2.4-2.3-2.3-2.3-2.5-2.4-2.3-2.4-2.3-2.3-2.4-2.3-2.3-2.2-2.1-2.2-2.1
BMI without tail1.64.96.7-2.4-2.2-2.1-2.3-2.3-2.1-2.1-2.3-2.2-2.2-2.2-2.1-2.2-2.1-2.1-2.1-2.2-2.2-2.2-2.6
Body weight1.98.49.4-3.0-2.9-2.8-2.9-3.0-3.0-2.9-2.5-3.0-3.0-2.9-3.0-2.9-2.9-2.9-2.9-2.8-3.1-2.8-3.0
Weight adjusted by age0.10.10.8-0.1-0.3-0.2-0.20.1-0.1-0.1-0.9-0.2-0.0-0.3-0.0-0.0-0.1-0.1-0.1-0.10.5-0.10.4
Bone surface0.00.00.1-0.00.0-0.10.10.00.20.2-0.30.1-0.10.10.2-0.10.20.20.20.0-0.10.10.0
Bone volume0.20.40.60.60.60.60.60.60.80.70.30.70.50.70.80.50.80.70.70.50.50.50.5
Breakpoint value in progressive ratio session0.00.00.2-0.1-0.1-0.10.0-0.10.10.10.10.50.10.3-0.0-0.0-0.1-0.1-0.1-0.1-0.0-0.00.5
Number of licking bursts0.10.11.30.10.30.4-0.1-0.1-0.1-0.20.3-0.10.1-0.1-0.30.0-0.2-0.2-0.20.1-0.1-0.4-1.1
Context. condit. distance diff. score1.31.62.01.31.41.41.21.31.31.31.11.41.21.41.21.31.31.21.21.21.41.20.8
Locomotion velocity, session 10.30.40.90.80.91.00.50.40.60.60.80.60.60.60.50.40.60.50.50.50.30.4-0.6
Locomotion distance, session 11.11.42.51.51.51.61.21.11.11.21.51.01.11.01.21.11.21.21.21.20.91.10.1
Locomotion velocity, session 20.10.10.80.30.50.5-0.0-0.00.10.10.30.30.00.3-0.0-0.00.10.10.10.1-0.3-0.1-0.9
Locomotion distance, session 21.01.42.91.61.61.71.21.11.01.11.51.21.31.21.01.11.11.11.11.21.00.8-0.0
Locomotion velocity, session 31.41.62.71.41.71.61.11.31.41.31.01.51.11.51.21.11.31.41.41.11.11.20.1
Locomotion distance, session 31.51.72.61.41.61.41.21.41.41.41.21.31.11.31.31.31.31.31.31.21.11.50.5
Stereotopy head waving bouts, day 31.41.72.61.61.51.61.41.21.21.21.51.31.31.31.11.31.21.21.21.31.11.20.8
Stereotopy head waving duration, day 30.00.00.10.1-0.1-0.00.1-0.2-0.10.00.20.0-0.10.00.1-0.00.00.10.1-0.1-0.20.10.1
Locomotion velocity, session 70.40.40.80.50.70.50.50.80.70.70.10.90.60.90.60.60.60.60.60.50.90.50.5
Locomotion distance, session 70.00.00.3-0.10.0-0.0-0.2-0.2-0.2-0.10.00.0-0.20.0-0.2-0.1-0.1-0.1-0.1-0.2-0.2-0.1-0.5
Stereotopy head waving bouts, day 73.13.54.32.02.12.11.82.02.01.91.32.11.72.11.81.81.91.91.91.81.91.70.9
Stereotopy head waving duration, day 70.70.81.40.90.91.00.80.91.11.00.41.20.81.21.00.81.01.01.00.81.00.80.5
Locomotion velocity, session 82.22.74.21.92.02.11.61.61.51.51.82.01.72.01.41.61.51.51.51.71.61.20.6
Locomotion distance, session 81.21.73.01.51.71.71.21.41.31.11.21.41.31.41.01.41.21.21.21.31.31.10.0
Degree of sensitization distance1.31.32.0-1.1-1.2-1.0-1.1-1.3-1.3-1.2-0.8-1.1-0.9-1.1-1.3-1.1-1.2-1.2-1.2-1.1-1.0-1.4-0.9
Degree of sensitization stereotypy2.22.43.71.41.61.61.41.71.81.70.71.91.41.91.61.41.61.61.61.51.71.40.9
Conditioned locomotion0.30.30.70.50.40.30.60.70.60.60.30.40.40.40.50.60.40.50.50.60.60.80.9
Cocaine response after cond. corrected0.30.40.8-0.8-0.5-0.6-0.7-0.7-0.4-0.3-0.9-0.2-0.7-0.2-0.7-0.8-0.6-0.4-0.4-0.8-0.7-0.6-0.8
Cocaine response after cond. not corrected1.01.11.7-1.2-0.9-1.0-1.2-1.2-0.8-0.8-1.3-0.7-1.1-0.7-1.1-1.2-1.0-0.9-0.9-1.2-1.1-1.2-1.3
Cocaine response before conditioning0.10.10.3-0.2-0.1-0.1-0.2-0.1-0.2-0.3-0.3-0.3-0.1-0.3-0.1-0.2-0.1-0.2-0.2-0.1-0.0-0.6-0.4
Saline control response0.70.91.6-1.2-1.1-1.2-0.9-0.7-0.9-1.0-1.3-1.0-0.9-1.0-0.9-0.9-1.0-1.0-1.0-0.7-0.6-0.9-0.5
Bone: connectivity density0.00.10.10.10.10.00.10.10.30.3-0.10.30.00.30.30.00.30.30.30.10.00.30.3
Bone: cortical apparent density3.04.25.31.92.11.81.92.22.32.11.62.22.02.22.12.12.12.12.12.02.22.01.7
Bone: cortical area0.40.55.50.3-0.1-0.30.60.80.60.30.10.30.70.30.50.70.40.30.30.81.10.62.3
Bone: cortical porosity0.10.10.20.30.20.40.30.20.10.20.30.30.20.30.20.30.20.10.10.20.20.10.1
Bone: cortical porosity0.30.30.50.50.50.60.60.50.40.50.50.70.60.70.50.50.50.50.50.50.60.30.6
Bone: cortical thickness1.21.97.81.10.70.51.31.71.41.20.71.11.51.11.41.41.21.21.21.52.01.22.8
Bone: cortical thickness0.40.51.1-0.8-0.9-1.0-0.7-0.4-0.7-0.7-0.8-1.0-0.6-1.0-0.7-0.5-0.7-0.7-0.7-0.5-0.3-0.5-0.1
Bone: cortical tissue density3.04.15.21.92.11.91.92.22.32.11.72.22.02.22.02.02.12.12.12.02.12.01.5
Condit. Reinf. active minus inactive responses0.10.10.40.10.30.10.00.40.30.1-0.3-0.10.0-0.10.10.20.10.10.10.20.40.2-0.6
Condit. Reinf. active-inactive response ratio0.10.10.4-0.4-0.3-0.5-0.30.10.0-0.1-0.6-0.2-0.2-0.2-0.2-0.1-0.1-0.1-0.1-0.10.2-0.0-0.1
Condit. Reinf. active responses0.10.11.20.10.30.2-0.10.30.20.1-0.4-0.3-0.1-0.3-0.10.10.10.00.00.10.10.1-1.1
Condit. Reinf. inactive responses0.10.11.0-0.00.00.1-0.2-0.3-0.2-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.2-0.3-0.3-0.3-0.4-0.3-1.0
Incentive salience index mean0.10.21.9-0.10.0-0.0-0.3-0.0-0.2-0.3-0.4-0.6-0.4-0.6-0.3-0.1-0.2-0.3-0.3-0.1-0.2-0.0-1.4
Condit. Reinf. lever presses0.10.11.10.50.50.60.30.20.10.10.3-0.0-0.0-0.00.10.30.20.20.20.3-0.10.4-1.1
Condit. Reinf. active minus inactive responses0.10.20.5-0.5-0.4-0.4-0.5-0.3-0.5-0.5-0.5-0.4-0.2-0.4-0.5-0.3-0.4-0.4-0.4-0.4-0.0-0.7-0.4
Condit. Reinf. active-inactive response ratio0.50.61.2-0.8-0.7-0.7-0.8-0.8-0.9-0.8-0.6-0.7-0.5-0.7-0.8-0.7-0.7-0.8-0.8-0.8-0.5-1.1-0.7
Condit. Reinf. active responses0.00.00.2-0.10.00.0-0.10.2-0.1-0.0-0.2-0.10.2-0.0-0.10.1-0.1-0.0-0.00.00.4-0.2-0.1
Condit. Reinf. inactive responses0.20.20.3-0.5-0.4-0.4-0.4-0.3-0.5-0.4-0.5-0.5-0.4-0.5-0.5-0.3-0.6-0.5-0.5-0.3-0.2-0.3-0.5
Condit. Reinf. lever presses0.00.00.1-0.1-0.1-0.0-0.1-0.1-0.1-0.1-0.1-0.10.0-0.1-0.3-0.1-0.3-0.1-0.1-0.10.1-0.3-0.2
Condit. Reinf. lever reinforcers received0.00.00.1-0.2-0.1-0.1-0.20.1-0.2-0.1-0.3-0.20.1-0.1-0.2-0.0-0.2-0.1-0.1-0.10.3-0.3-0.2
Conditioned reinforcement - actives0.71.31.9-1.2-1.3-1.4-1.2-1.2-1.3-1.3-1.0-0.6-1.1-0.6-1.3-1.1-1.2-1.2-1.2-1.1-1.0-1.00.2
Conditioned reinforcement - inactives0.10.10.50.40.10.30.30.30.20.20.00.10.30.10.40.20.30.30.30.30.50.10.7
Conditioned locomotion0.70.84.20.90.60.60.70.90.80.70.61.30.81.30.60.70.60.60.60.80.91.02.1
Patch foraging indifference point 0 sec0.71.32.3-1.4-1.1-1.3-1.2-1.3-1.2-0.9-1.1-0.7-1.4-0.7-1.0-1.3-0.9-0.9-0.9-1.2-1.4-0.9-1.5
Patch foraging indifference point AUC0.60.91.8-0.7-0.9-0.6-0.9-1.1-1.0-0.9-0.4-1.3-0.8-1.3-1.0-0.9-0.9-0.9-0.9-0.9-1.1-0.9-0.6
Delay disc. indifference point, 0s delay0.00.00.10.10.20.20.10.20.30.2-0.0-0.20.2-0.20.20.30.20.20.20.10.40.0-0.3
Delay disc. indifference point, 16s delay0.10.10.4-0.5-0.5-0.6-0.3-0.3-0.2-0.2-0.10.0-0.3-0.0-0.0-0.3-0.1-0.1-0.1-0.2-0.3-0.00.6
Delay disc. indifference point, 2s delay0.00.00.1-0.2-0.2-0.1-0.2-0.2-0.1-0.1-0.4-0.0-0.20.0-0.1-0.2-0.1-0.1-0.1-0.2-0.1-0.2-0.2
Delay disc. indifference point, 24s delay2.12.43.7-1.7-1.4-1.5-1.7-1.7-1.7-1.5-1.4-1.2-1.6-1.2-1.5-1.6-1.4-1.4-1.4-1.5-1.8-1.5-1.9
Delay disc. indifference point, 4s delay0.10.10.70.10.30.20.00.00.1-0.10.3-0.3-0.1-0.2-0.10.2-0.1-0.1-0.1-0.0-0.30.0-0.8
Delay disc. indifference point, 8s delay1.61.92.3-1.5-1.4-1.5-1.5-1.5-1.5-1.4-1.3-1.2-1.4-1.2-1.3-1.3-1.3-1.3-1.3-1.3-1.5-1.3-1.2
Indifference point function ln k0.00.00.30.10.2-0.10.10.30.00.0-0.20.50.10.50.10.10.10.10.10.20.20.10.1
Indifference point function log k0.00.00.30.10.2-0.10.10.30.00.0-0.20.50.10.50.10.10.10.10.10.20.20.10.1
Patch foraging total patch changes 0 sec0.71.32.2-1.3-1.0-1.2-1.2-1.2-1.2-0.9-1.1-0.8-1.4-0.7-1.0-1.3-0.9-1.0-1.0-1.2-1.4-0.8-1.5
Patch foraging total patch changes 12 sec1.41.82.4-1.4-1.3-1.3-1.4-1.3-1.5-1.3-1.2-1.5-1.3-1.4-1.4-1.2-1.4-1.4-1.4-1.1-1.4-1.3-1.6
Patch foraging total patch changes 18 sec0.81.21.6-1.2-1.1-1.0-1.1-1.2-1.2-1.1-0.7-1.0-1.0-1.0-1.2-1.1-1.1-1.2-1.2-1.1-1.0-1.1-0.7
Patch foraging total patch changes 24 sec1.62.84.0-2.0-1.8-1.9-1.8-1.7-1.6-1.6-1.6-1.6-1.7-1.5-1.6-1.7-1.6-1.6-1.6-1.7-1.7-1.8-1.2
Patch foraging total patch changes 6 sec1.32.03.1-1.6-1.4-1.4-1.5-1.6-1.4-1.2-1.3-1.2-1.6-1.1-1.4-1.5-1.3-1.3-1.3-1.4-1.8-1.3-1.7
Patch foraging time to switch 0 sec0.00.10.2-0.3-0.2-0.3-0.2-0.1-0.1-0.4-0.4-0.1-0.1-0.1-0.3-0.2-0.3-0.3-0.3-0.20.2-0.4-0.3
Patch foraging water rate 0 sec0.10.10.60.40.30.40.40.30.30.50.40.30.10.30.20.40.30.30.30.5-0.10.80.2
Patch foraging water rate 12 sec0.71.42.51.11.01.11.11.41.61.10.71.21.21.21.01.41.11.01.01.41.61.21.0
Patch foraging water rate 18 sec0.30.50.9-0.9-0.9-0.8-0.7-0.5-0.3-0.6-1.0-0.6-0.5-0.7-0.7-0.5-0.7-0.7-0.7-0.5-0.2-0.8-0.4
Patch foraging water rate 24 sec0.40.50.8-0.7-0.7-0.7-0.7-0.6-0.8-0.8-0.8-0.8-0.8-0.7-0.9-0.6-0.9-0.8-0.8-0.6-0.8-0.5-0.7
Patch foraging water rate 6 sec1.52.23.51.61.41.51.51.51.51.41.61.51.41.51.31.61.31.31.31.61.31.61.9
Seeking ratio, delayed vs. immediate footshock0.20.20.80.60.50.70.30.50.1-0.00.5-0.50.1-0.4-0.10.50.00.00.00.60.00.5-0.9
Distance traveled before self-admin0.10.20.4-0.4-0.3-0.3-0.3-0.4-0.3-0.5-0.3-0.6-0.3-0.5-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.6-0.6
Distance traveled after self-admin2.02.45.8-1.4-1.2-1.3-1.4-1.4-1.5-1.6-1.2-2.1-1.5-2.1-1.6-1.3-1.4-1.4-1.4-1.3-1.6-1.5-2.4
Extensor digitorum longus weight0.00.00.10.0-0.1-0.1-0.0-0.0-0.3-0.20.1-0.2-0.1-0.3-0.30.0-0.2-0.2-0.20.2-0.10.0-0.1
Bone: elastic displacement1.01.22.41.10.91.11.00.70.91.11.31.41.21.41.10.81.11.01.00.80.90.61.6
Bone: elastic work0.50.71.80.80.60.80.80.60.70.90.91.00.91.00.80.60.80.80.80.70.70.61.3
Bone: endosteal estimation0.51.11.5-1.0-1.0-0.9-0.9-0.9-1.1-1.1-0.9-1.2-1.0-1.2-1.1-0.9-1.1-1.1-1.1-0.9-1.0-0.8-1.0
Bone: endosteal perimeter0.20.40.9-0.6-0.8-0.7-0.5-0.4-0.5-0.7-0.7-0.9-0.5-0.9-0.7-0.4-0.7-0.7-0.7-0.3-0.4-0.4-0.2
Epididymis fat weight1.96.57.4-2.6-2.5-2.4-2.6-2.5-2.4-2.5-2.5-2.6-2.4-2.6-2.7-2.4-2.6-2.6-2.6-2.4-2.3-2.6-2.7
Delta time in closed arm before/after self-admin1.21.21.71.01.00.91.11.21.21.11.01.01.20.91.01.11.01.01.01.11.11.11.3
Delta time in open arm before/after self-admin0.80.81.7-1.0-1.0-0.9-0.9-0.7-0.8-0.9-1.3-1.0-0.8-1.1-0.8-0.8-0.8-0.8-0.8-0.8-0.3-1.0-0.7
Diff in mean of infusions in LGA sessions0.60.72.20.80.60.60.80.80.90.80.81.00.80.90.90.60.80.80.80.70.60.71.5
Delay discount exponential model param0.50.50.90.90.80.90.80.80.80.70.70.50.80.50.60.70.70.70.70.80.90.70.5
Extinction: sum of active levers before priming0.00.10.2-0.2-0.1-0.1-0.2-0.20.0-0.2-0.40.3-0.10.3-0.3-0.1-0.3-0.3-0.3-0.20.1-0.2-0.1
Active lever presses in extinction session 60.30.30.60.50.40.40.60.50.50.60.60.40.30.20.60.60.50.50.50.60.20.80.3
Bone: final force0.10.10.4-0.3-0.5-0.6-0.2-0.0-0.4-0.3-0.4-0.4-0.0-0.4-0.3-0.1-0.4-0.4-0.4-0.10.2-0.40.6
Bone: final moment0.10.10.4-0.4-0.5-0.6-0.2-0.1-0.4-0.3-0.4-0.4-0.1-0.4-0.3-0.2-0.3-0.4-0.4-0.10.1-0.40.6
Food consumed during 24 hour testing period1.42.03.3-1.5-1.2-1.2-1.4-1.0-1.2-1.5-1.8-1.8-1.1-1.7-1.3-1.3-1.4-1.4-1.4-1.3-0.7-1.6-1.7
Glucose0.71.12.01.31.21.21.11.41.00.81.00.91.40.90.71.20.70.70.71.21.40.81.2
Heart weight1.62.53.3-1.8-1.8-1.6-1.7-1.8-1.5-1.6-1.5-1.3-1.6-1.3-1.6-1.7-1.6-1.6-1.6-1.8-1.4-1.6-1.1
Delay discount hyperbolic model param0.30.40.70.80.60.70.70.70.60.60.60.40.70.40.50.60.50.50.50.60.80.60.5
Intermittent access intake day 1-15 change0.10.30.80.60.30.50.50.50.50.50.40.30.60.30.40.50.50.50.50.60.70.20.9
Intermittent access intake escalation0.20.50.80.80.50.80.70.70.70.70.60.30.80.30.60.70.70.70.70.80.90.40.9
Intermittent access intake escalation 20.20.21.10.30.00.20.40.40.30.30.40.20.40.20.40.50.40.40.40.50.50.21.1
Intermitt. access day 1 inactive lever presses1.34.86.52.32.02.12.32.42.52.21.81.92.21.92.22.32.12.12.12.32.42.22.5
Intermitt. access day 15 inactive lever presses1.73.55.02.02.22.11.82.02.01.81.52.02.02.01.71.91.81.81.82.02.01.51.1
Intermitt. access escalation Index0.30.40.70.80.90.80.70.80.60.50.70.00.7-0.00.60.80.60.60.60.80.60.4-0.5
Intermittent access day 1 total infusions1.72.73.8-1.6-1.6-1.5-1.7-1.7-1.8-1.9-1.5-1.4-1.6-1.4-1.9-1.6-1.8-1.8-1.8-1.6-1.5-1.6-1.3
Intermittent access day 15 total infusions0.20.30.5-0.4-0.6-0.4-0.6-0.4-0.6-0.6-0.6-0.5-0.4-0.5-0.7-0.5-0.5-0.5-0.5-0.4-0.2-0.7-0.0
Intermittent access terminal intake (last 3 days)0.10.20.4-0.3-0.5-0.3-0.5-0.4-0.5-0.5-0.5-0.4-0.3-0.4-0.6-0.4-0.4-0.4-0.4-0.3-0.1-0.70.3
Intermittent access total infusions0.60.71.1-0.8-0.9-0.8-0.9-0.9-1.0-1.1-0.9-0.7-0.8-0.7-1.1-0.9-0.9-0.9-0.9-0.8-0.6-1.0-0.3
Intermittent access day 1 locomotion0.50.60.9-0.6-0.9-0.7-0.8-0.7-0.8-0.9-0.8-0.9-0.8-0.9-0.9-0.8-0.9-0.9-0.9-0.7-0.6-0.8-0.2
Intermittent access day 15 total locomotion1.22.13.5-1.5-1.8-1.5-1.6-1.6-1.5-1.4-1.9-1.2-1.4-1.2-1.5-1.7-1.4-1.4-1.4-1.6-1.1-1.70.1
Intermittent access total locomotion0.10.10.3-0.1-0.5-0.2-0.3-0.3-0.3-0.4-0.5-0.3-0.3-0.3-0.4-0.3-0.3-0.3-0.3-0.3-0.1-0.40.5
Intermittent access standard deviation0.10.20.40.60.40.60.40.60.50.40.30.10.50.10.20.50.30.30.30.50.70.40.4
Left kidney weight4.721.825.3-5.0-4.8-4.7-4.9-4.9-4.5-4.7-4.6-4.6-4.9-4.5-4.6-4.7-4.6-4.6-4.6-4.6-4.8-4.4-4.5
Right kidney weight5.525.229.3-5.4-5.2-5.1-5.3-5.1-4.9-5.1-4.9-5.0-5.1-4.9-5.1-5.0-5.1-5.1-5.1-4.9-5.0-4.7-4.3
Cocaine induced anxiety0.10.10.50.10.1-0.00.20.20.20.30.20.60.10.60.30.20.30.30.30.20.10.50.7
Post-drug Anxiety0.20.20.5-0.6-0.6-0.7-0.5-0.5-0.5-0.4-0.50.3-0.50.3-0.4-0.5-0.5-0.5-0.5-0.5-0.5-0.20.4
Baseline Anxiety0.10.10.3-0.1-0.10.0-0.4-0.4-0.5-0.4-0.2-0.2-0.3-0.2-0.5-0.4-0.4-0.4-0.4-0.4-0.4-0.6-0.5
Tail length0.72.85.8-1.6-1.5-1.4-1.7-1.8-1.6-1.6-1.4-1.7-1.8-1.7-1.7-1.6-1.5-1.5-1.5-1.6-2.0-1.6-2.4
Length with tail1.14.66.7-2.1-2.1-2.0-2.2-2.3-2.2-2.2-1.7-2.2-2.3-2.1-2.1-2.1-2.0-2.1-2.1-2.0-2.6-2.0-2.4
Length without tail0.92.93.8-1.5-1.7-1.6-1.6-1.7-1.8-1.9-1.3-1.9-1.7-1.9-1.8-1.5-1.8-1.8-1.8-1.4-1.8-1.5-1.8
Times rat made contact with spout2.83.24.2-2.0-1.7-1.8-1.9-1.6-1.6-1.8-1.9-1.9-1.6-1.9-1.7-1.8-1.7-1.8-1.8-1.9-1.3-1.7-2.0
Lifetime Intake0.50.61.0-0.7-0.7-0.6-0.8-0.8-0.9-1.0-0.7-0.7-0.7-0.7-1.0-0.7-0.8-0.8-0.8-0.7-0.7-0.8-0.5
Liver weight, left5.49.010.3-3.2-3.0-3.1-3.1-2.9-3.2-3.1-2.9-3.0-2.9-3.0-3.1-2.9-3.2-3.1-3.1-2.9-2.6-2.9-2.9
Liver weight, right1.22.14.0-1.5-1.3-1.4-1.4-1.3-1.3-1.4-1.4-1.8-1.6-1.8-1.4-1.2-1.4-1.5-1.5-1.1-1.5-1.0-2.0
Locomotor activity0.10.20.7-0.5-0.3-0.3-0.6-0.3-0.6-0.4-0.9-0.0-0.3-0.0-0.6-0.5-0.5-0.5-0.5-0.4-0.2-0.7-0.5
Locomotor testing distance1.73.16.3-2.2-1.8-2.0-2.0-1.6-1.8-1.7-2.5-1.2-1.6-1.1-1.7-1.9-1.7-1.8-1.8-1.7-1.3-2.0-1.0
Locomotor testing rearing0.91.84.7-1.8-1.5-1.8-1.5-1.2-1.2-1.2-2.2-0.6-1.3-0.6-1.2-1.5-1.2-1.3-1.3-1.5-0.8-1.2-0.2
Locomotion in novel chamber0.50.71.40.90.90.90.80.80.80.80.51.20.71.20.70.60.70.80.80.70.80.90.8
Locomotion in novel chamber post-restriction0.20.31.10.60.90.80.50.20.50.50.90.20.20.20.40.20.50.50.50.1-0.30.6-1.1
Fecal boli incidents, locomotor time 10.00.00.20.2-0.00.20.2-0.10.00.10.4-0.10.2-0.20.20.10.20.20.2-0.00.1-0.00.3
Change in fecal boli incidents, locomotor task0.20.20.60.50.80.60.30.50.40.20.40.70.40.70.10.40.10.10.10.50.30.4-0.0
Time >=10cm from walls, locomotor time 12.32.53.51.71.61.41.81.51.51.61.91.51.51.51.61.61.51.51.51.41.21.91.7
Bouts of movement, locomotor time 10.70.81.1-1.0-1.1-1.1-0.9-0.9-0.8-0.9-1.1-1.0-0.9-1.0-0.9-0.8-0.9-0.9-0.9-1.0-0.6-0.9-0.5
Total resting periods, locomotor time 11.01.21.5-1.1-1.2-1.2-1.1-1.1-1.1-1.1-1.1-1.2-1.0-1.2-1.1-1.0-1.1-1.1-1.1-1.2-0.8-1.1-0.7
Rest time, locomotor task time 10.10.20.60.50.60.80.40.40.40.20.50.20.50.10.20.40.30.30.30.30.50.1-0.4
Distance moved, locomotor task time 10.20.30.8-0.8-0.8-0.9-0.5-0.5-0.4-0.3-0.8-0.4-0.7-0.3-0.2-0.5-0.3-0.3-0.3-0.6-0.5-0.1-0.1
Vertical activity count, locomotor time 10.00.10.5-0.4-0.5-0.7-0.1-0.0-0.00.1-0.4-0.1-0.4-0.10.1-0.1-0.0-0.0-0.0-0.2-0.20.60.7
Time >=10cm from walls, locomotor time 20.10.10.30.30.60.40.30.20.30.10.30.40.20.40.10.20.10.10.10.0-0.00.3-0.2
Bouts of movement, locomotor time 20.10.10.50.40.70.40.30.40.40.30.30.50.30.50.30.30.30.30.30.30.10.20.1
Total resting periods, locomotor time 20.10.20.60.50.80.50.30.50.40.40.30.60.40.50.30.40.40.40.40.40.30.20.1
Rest time, locomotor task time 20.10.21.00.20.20.40.40.40.40.40.10.30.60.20.40.40.40.40.40.31.0-0.10.4
Distance moved, locomotor task time 20.30.40.8-0.8-0.6-0.8-0.7-0.5-0.5-0.6-0.9-0.6-0.8-0.5-0.6-0.7-0.6-0.6-0.6-0.6-0.8-0.2-0.7
Vertical activity count, locomotor time 20.10.10.3-0.4-0.2-0.4-0.3-0.0-0.1-0.2-0.5-0.2-0.4-0.1-0.2-0.2-0.3-0.3-0.3-0.2-0.30.2-0.3
Light reinforcement 11.02.53.2-1.7-1.7-1.7-1.5-1.6-1.8-1.6-1.3-1.7-1.6-1.7-1.6-1.5-1.6-1.7-1.7-1.5-1.7-1.3-1.3
Light reinforcement 20.10.21.1-0.1-0.3-0.1-0.1-0.2-0.3-0.40.2-1.1-0.2-1.0-0.3-0.0-0.4-0.4-0.40.0-0.3-0.1-0.6
Bone: marrow area0.51.11.6-1.0-1.0-0.9-0.9-1.0-1.1-1.1-0.9-1.2-1.0-1.2-1.1-0.9-1.1-1.1-1.1-0.9-1.0-0.9-1.0
Bone: maximum diameter0.51.02.0-1.1-1.3-1.4-0.8-0.7-0.9-1.1-1.2-1.1-0.8-1.1-1.0-0.8-1.1-1.1-1.1-0.7-0.6-0.70.5
Bone: maximum force0.20.40.9-0.7-0.8-1.0-0.5-0.4-0.6-0.6-0.7-0.7-0.4-0.7-0.6-0.5-0.6-0.7-0.7-0.5-0.1-0.70.3
Bone: maximum moment0.20.40.9-0.8-0.8-1.0-0.5-0.4-0.6-0.5-0.7-0.7-0.4-0.7-0.5-0.5-0.6-0.6-0.6-0.5-0.2-0.70.3
Mean time between licks in bursts0.71.82.8-1.5-1.5-1.6-1.4-1.5-1.5-1.4-1.1-1.0-1.2-1.0-1.3-1.4-1.5-1.3-1.3-1.4-1.3-1.7-0.3
Mean num. licks in bursts0.71.12.4-1.3-1.3-1.5-1.0-0.8-0.8-0.9-1.5-1.1-1.0-1.1-0.7-1.1-0.8-0.9-0.9-1.2-0.6-0.70.0
Cd content in liver0.00.00.3-0.2-0.2-0.3-0.10.10.0-0.0-0.50.1-0.00.10.0-0.1-0.0-0.0-0.0-0.10.3-0.10.5
Co content in liver0.40.51.7-0.8-0.8-0.7-0.7-0.5-0.5-0.6-1.3-0.5-0.7-0.6-0.6-0.7-0.6-0.6-0.6-0.7-0.4-0.7-0.7
Cu content in liver0.20.20.40.30.40.40.40.30.60.60.10.60.40.60.50.30.50.50.50.30.40.40.4
Fe content in liver1.21.52.01.21.11.21.21.21.31.21.11.21.11.21.21.31.21.21.21.41.21.11.0
K content in liver0.60.60.8-0.9-0.9-0.8-0.8-0.8-0.6-0.6-0.9-0.9-0.9-0.8-0.6-0.8-0.6-0.6-0.6-0.8-0.8-0.5-0.9
Mg content in liver0.40.40.80.60.40.60.70.70.80.70.40.40.70.30.70.60.60.60.60.60.90.50.8
Mn content in liver3.13.44.21.91.71.71.91.82.12.01.61.81.81.92.01.82.02.02.01.71.91.81.8
Na content in liver0.60.71.0-0.8-1.0-0.8-0.8-0.8-0.7-0.8-0.8-0.9-0.9-1.0-0.8-0.7-0.8-0.8-0.8-0.7-0.8-0.6-0.8
Rb content in liver0.10.10.3-0.5-0.6-0.5-0.3-0.2-0.2-0.3-0.4-0.5-0.2-0.5-0.3-0.2-0.3-0.3-0.3-0.3-0.0-0.20.2
Se content in liver2.73.24.31.81.81.81.81.81.92.11.41.71.61.72.01.62.02.02.01.61.72.01.2
Sr content in liver0.10.00.10.30.10.20.20.30.1-0.1-0.2-0.4-0.1-0.4-0.00.3-0.0-0.0-0.00.40.00.2-0.3
Zn content in liver0.10.10.30.40.30.40.30.40.50.50.00.30.30.30.40.30.50.50.50.40.50.40.2
Bone: minimum diameter1.22.15.91.41.11.01.51.71.41.31.21.11.61.11.41.51.31.31.31.61.81.42.4
Time in familiar zone, hab. session 10.10.00.10.10.20.2-0.10.0-0.3-0.30.10.30.10.3-0.30.0-0.3-0.3-0.30.10.0-0.20.0
Time in novel zone, hab. session 12.22.23.8-1.9-1.7-1.9-1.6-1.5-1.2-1.2-2.0-1.3-1.6-1.3-1.2-1.6-1.2-1.1-1.1-1.6-1.3-1.5-0.9
Total zone transitions, hab. session 11.11.52.71.61.71.61.31.41.11.01.51.11.21.11.01.41.11.11.11.51.01.20.0
Total locomotion distance, hab. session 10.91.32.61.41.41.31.21.11.11.11.61.11.11.11.11.21.11.11.11.20.81.10.6
Locomotion velocity, hab. session 11.82.54.61.91.81.81.81.51.51.52.11.41.51.41.51.71.51.51.51.61.21.70.9
Time in familiar zone, hab. session 21.71.82.5-1.5-1.5-1.6-1.4-1.3-1.4-1.5-1.4-0.9-1.3-0.9-1.3-1.4-1.3-1.4-1.4-1.4-1.2-1.3-0.5
Time in novel zone, hab. session 20.10.10.10.20.30.40.20.20.30.40.10.30.10.30.20.20.20.30.30.20.20.2-0.3
Total zone transitions, hab. session 20.10.21.90.20.40.5-0.1-0.2-0.3-0.30.3-0.1-0.1-0.1-0.3-0.0-0.2-0.2-0.20.0-0.4-0.3-1.4
Total locomotion distance, hab. session 20.10.20.50.60.60.60.40.30.30.20.70.30.40.30.20.40.20.20.20.40.30.2-0.2
Locomotion velocity, hab. session 20.10.20.60.60.70.70.40.30.20.20.80.30.40.30.20.40.20.20.20.40.20.2-0.4
Novel to familiar place preference ratio0.30.30.60.50.50.30.60.80.70.60.20.60.60.60.60.60.50.50.50.60.70.80.8
Novelty place preference0.30.30.60.40.40.20.50.70.60.50.10.50.50.50.60.60.40.40.40.60.70.70.8
Time in novel zone, NPP test0.40.41.00.40.50.30.60.80.70.60.10.80.50.80.60.60.50.50.50.60.70.81.0
Total zone transitions, NPP test0.71.02.51.41.61.61.00.90.90.81.30.81.00.80.80.91.00.90.91.00.60.6-0.8
Total locomotion distance, NPP test1.92.63.91.92.01.91.61.51.61.51.91.61.71.51.51.61.61.61.61.51.41.30.7
Locomotion velocity, NPP test1.72.43.71.91.91.91.61.51.61.51.91.21.61.21.51.61.51.51.51.51.41.20.4
Intraocular pressure5.98.511.33.23.43.12.93.22.92.92.73.02.83.02.73.12.82.82.83.02.63.22.0
Delta distance traveled before/after self-admin1.61.72.5-1.2-1.1-1.2-1.2-1.2-1.3-1.3-1.1-1.5-1.4-1.6-1.4-1.2-1.3-1.3-1.3-1.2-1.4-1.0-1.6
Delta ambulatory time before/after self-admin1.72.13.0-1.4-1.3-1.3-1.5-1.4-1.5-1.5-1.3-1.5-1.5-1.6-1.6-1.3-1.5-1.5-1.5-1.4-1.4-1.3-1.7
Parametrial fat weight0.00.10.2-0.3-0.5-0.3-0.3-0.4-0.2-0.1-0.5-0.3-0.4-0.3-0.3-0.3-0.2-0.2-0.2-0.3-0.2-0.2-0.2
Pavlov. Cond. lever latency0.10.10.5-0.3-0.1-0.3-0.00.00.20.3-0.20.50.10.50.3-0.10.30.30.3-0.10.2-0.00.7
Pavlov. Cond. magazine entry latency2.22.94.1-1.7-1.6-1.6-1.7-1.8-1.7-1.7-1.5-1.6-1.9-1.6-1.6-1.7-1.6-1.7-1.7-1.6-2.0-1.5-2.0
Pavlov. Cond. change in total contacts0.40.40.6-0.5-0.6-0.7-0.6-0.6-0.6-0.6-0.6-0.6-0.8-0.6-0.6-0.6-0.7-0.7-0.7-0.6-0.8-0.3-0.4
Pavlov. Cond. index score1.01.31.8-0.9-1.0-1.0-1.0-1.1-1.2-1.2-0.9-1.2-1.2-1.2-1.2-1.0-1.2-1.2-1.2-1.0-1.4-0.9-1.3
Pavlov. Cond. latency score0.81.01.4-0.8-0.9-0.8-0.9-1.0-1.1-1.1-0.7-1.1-1.0-1.1-1.1-0.9-1.1-1.1-1.1-0.8-1.2-0.8-1.1
Pavlov. Cond. lever contacts0.10.10.40.60.40.50.40.40.20.20.60.10.20.10.20.40.20.10.10.50.10.5-0.1
Pavlov. Cond. magazine entry number4.76.07.22.52.42.52.42.52.52.42.32.52.72.52.42.42.42.52.52.42.72.12.5
Pavlov. Cond. intertrial magazine entries0.80.91.41.11.11.21.11.01.01.01.00.71.00.70.91.00.90.90.90.91.01.00.6
Pavlov. Cond. lever-magazine prob. diff.0.60.81.5-0.7-0.7-0.7-0.8-0.8-0.9-0.9-0.7-0.9-1.0-0.9-0.9-0.8-0.9-0.9-0.9-0.7-1.1-0.6-1.2
Pavlov. Cond. response bias1.72.13.5-1.3-1.3-1.3-1.4-1.4-1.4-1.4-1.3-1.5-1.6-1.5-1.4-1.4-1.4-1.5-1.5-1.3-1.7-1.0-1.9
Pavlov. Cond. lever latency0.00.00.10.1-0.00.00.0-0.1-0.1-0.10.20.10.00.10.1-0.10.1-0.0-0.0-0.0-0.1-0.10.3
Pavlov. Cond. magazine entry latency4.55.57.1-2.7-2.4-2.5-2.4-2.2-2.3-2.2-2.7-2.4-2.2-2.4-2.3-2.4-2.3-2.2-2.2-2.4-2.0-2.4-2.1
Pavlov. Cond. change in total contacts0.10.20.3-0.4-0.4-0.4-0.4-0.3-0.4-0.4-0.4-0.5-0.3-0.5-0.5-0.3-0.5-0.5-0.5-0.4-0.2-0.5-0.2
Pavlov. Cond. index score1.31.72.6-1.5-1.4-1.4-1.4-1.2-1.3-1.2-1.6-1.4-1.2-1.4-1.4-1.3-1.4-1.2-1.2-1.3-1.0-1.4-1.1
Pavlov. Cond. latency score1.72.33.4-1.7-1.5-1.6-1.6-1.3-1.4-1.4-1.8-1.5-1.4-1.6-1.5-1.5-1.5-1.4-1.4-1.5-1.2-1.5-1.4
Pavlov. Cond. lever contacts0.00.00.1-0.10.0-0.1-0.10.10.10.1-0.3-0.10.0-0.1-0.10.1-0.10.00.00.00.2-0.1-0.3
Pavlov. Cond. magazine entry number3.54.35.72.42.32.32.11.92.02.02.32.21.92.22.12.02.12.02.02.11.72.11.4
Pavlov. Cond. intertrial magazine entries0.50.71.61.00.80.90.80.70.60.61.30.80.80.90.90.80.80.70.70.90.60.91.2
Pavlov. Cond. lever-magazine prob. diff.1.62.13.0-1.7-1.5-1.6-1.5-1.3-1.4-1.3-1.7-1.5-1.3-1.5-1.5-1.4-1.5-1.3-1.3-1.5-1.1-1.5-1.3
Pavlov. Cond. response bias0.20.30.6-0.7-0.6-0.7-0.6-0.3-0.4-0.4-0.8-0.7-0.5-0.6-0.5-0.4-0.6-0.5-0.5-0.5-0.2-0.5-0.4
Time in closed arm before self-admin0.91.21.71.31.21.21.21.11.11.21.30.91.01.01.01.11.11.11.11.10.81.00.5
Time in closed arm after self-admin1.41.52.01.31.41.31.31.31.41.41.41.11.31.21.21.21.21.21.21.21.11.11.0
Time in open arm before self-admin3.13.33.9-1.9-1.9-1.7-1.9-2.0-2.0-2.0-1.7-1.7-1.8-1.8-1.8-1.9-1.8-1.8-1.8-1.9-1.8-1.8-1.6
Time in open arm after self-admin3.74.15.7-2.0-1.9-1.8-2.1-1.9-2.0-2.2-2.2-2.2-2.0-2.3-1.9-1.9-1.8-1.8-1.8-1.9-1.7-2.0-2.4
Bone: periosteal estimation0.10.10.9-0.2-0.5-0.60.00.2-0.2-0.3-0.3-0.5-0.0-0.5-0.20.0-0.3-0.4-0.40.20.20.00.9
Bone: periosteal perimeter0.10.21.6-0.4-0.8-0.8-0.1-0.1-0.3-0.3-0.3-0.5-0.1-0.5-0.1-0.1-0.3-0.3-0.30.00.1-0.11.3
Bone: post-yield work0.20.30.5-0.5-0.6-0.6-0.4-0.7-0.6-0.5-0.1-0.6-0.6-0.6-0.5-0.5-0.5-0.4-0.4-0.5-0.7-0.3-0.5
Progressive ratio test 1 active lever presses0.20.20.4-0.3-0.4-0.3-0.4-0.5-0.6-0.6-0.1-0.5-0.4-0.5-0.6-0.4-0.5-0.5-0.5-0.4-0.4-0.5-0.3
Progressive ratio test 1 breakpoint0.10.10.3-0.2-0.3-0.2-0.3-0.4-0.5-0.5-0.1-0.5-0.3-0.5-0.5-0.3-0.4-0.4-0.4-0.3-0.3-0.4-0.2
Progressive ratio test 1 inactive lever presses0.10.20.50.60.60.70.40.30.20.30.60.60.30.60.20.40.30.30.30.40.20.40.2
Progressive ratio test 2 active lever presses2.12.53.4-1.5-1.7-1.5-1.6-1.5-1.7-1.8-1.6-1.6-1.4-1.7-1.8-1.5-1.7-1.7-1.7-1.4-1.2-1.7-0.7
Progressive ratio test 2 breakpoint1.92.23.1-1.3-1.6-1.3-1.5-1.4-1.6-1.8-1.5-1.6-1.3-1.6-1.7-1.4-1.6-1.6-1.6-1.3-1.1-1.6-0.7
Progressive ratio test 2 inactive lever presses0.40.61.0-0.8-0.9-0.8-0.9-0.8-0.9-0.9-1.0-0.4-0.8-0.4-0.9-0.8-0.9-0.9-0.9-0.7-0.6-0.80.1
Incentive Sensitization - Responses3.44.85.7-2.2-2.3-2.2-2.3-2.2-2.3-2.4-2.4-2.1-2.1-2.2-2.3-2.1-2.3-2.3-2.3-2.1-1.9-2.3-1.5
Incentive Sensitization - Breakpoint3.54.65.4-2.2-2.2-2.1-2.2-2.1-2.3-2.3-2.3-2.0-2.0-2.1-2.3-2.1-2.2-2.2-2.2-2.0-1.8-2.3-1.5
Sum of active levers in priming session hrs 5-60.10.10.1-0.2-0.2-0.1-0.2-0.2-0.1-0.2-0.1-0.1-0.2-0.2-0.3-0.2-0.3-0.3-0.3-0.2-0.3-0.2-0.3
Progressive ratio0.30.50.7-0.8-0.6-0.6-0.7-0.6-0.6-0.7-0.8-0.6-0.7-0.6-0.7-0.7-0.7-0.7-0.7-0.7-0.5-0.7-0.7
Food seeking constrained by brief footshock1.72.12.8-1.4-1.2-1.3-1.5-1.5-1.6-1.5-1.2-1.1-1.4-1.1-1.6-1.5-1.5-1.5-1.5-1.6-1.5-1.7-1.7
Seeking ratio, punishment vs. effort0.10.10.3-0.1-0.1-0.2-0.2-0.4-0.4-0.30.1-0.3-0.2-0.3-0.3-0.3-0.3-0.2-0.2-0.3-0.5-0.3-0.4
Retroperitoneal fat weight0.62.43.8-1.6-1.6-1.3-1.5-1.6-1.4-1.5-1.5-1.8-1.5-1.8-1.5-1.5-1.5-1.4-1.4-1.6-1.3-1.7-1.9
Reaction time number correct1.12.12.61.41.51.51.41.51.51.51.31.61.31.61.41.51.51.51.51.41.41.61.2
Reaction time mean minus median0.00.00.20.30.40.40.00.0-0.10.20.30.20.30.10.00.00.10.20.2-0.10.1-0.2-0.3
Reaction time mean minus median AUC0.10.20.7-0.4-0.2-0.2-0.6-0.5-0.7-0.3-0.4-0.3-0.2-0.3-0.5-0.5-0.4-0.3-0.3-0.7-0.4-0.9-0.6
Reaction time num false alarms0.40.50.8-0.8-0.8-0.9-0.6-0.7-0.8-0.8-0.6-0.8-0.7-0.8-0.6-0.7-0.7-0.8-0.8-0.8-0.7-0.6-0.3
Reaction time num false alarms AUC0.50.81.1-1.0-1.0-1.1-0.8-0.9-1.0-1.0-0.7-0.9-0.9-0.9-0.9-0.9-0.9-1.0-1.0-0.9-0.9-0.9-0.5
Reaction time trials correct on left1.12.12.61.41.51.51.41.51.51.51.31.61.31.61.41.51.51.51.51.41.41.61.2
Reaction time trials on left1.32.43.11.51.61.61.51.61.61.61.31.71.41.81.51.51.61.61.61.51.51.61.3
Reaction time mean0.40.71.50.81.00.80.61.00.70.70.50.81.10.80.60.80.60.70.70.81.20.30.8
Reaction time mean AUC0.30.51.10.80.90.70.50.90.60.70.40.71.00.70.50.70.60.60.60.71.10.20.6
Median of all reaction times0.30.51.30.60.80.50.50.90.60.60.20.70.90.70.50.70.50.60.60.71.10.20.9
Reaction time omissions1.01.53.30.91.41.10.91.21.21.20.41.81.41.81.20.91.21.31.30.81.60.61.4
Reaction time false alarm rate1.82.53.0-1.6-1.6-1.7-1.5-1.6-1.7-1.7-1.3-1.7-1.5-1.7-1.5-1.6-1.6-1.7-1.7-1.5-1.5-1.6-1.2
Reaction time premature initiation rate4.15.77.3-2.6-2.5-2.4-2.5-2.7-2.3-2.4-2.1-2.0-2.4-1.9-2.5-2.5-2.4-2.4-2.4-2.5-2.6-2.6-2.1
Reaction time premature initiations0.81.42.0-1.4-1.2-1.2-1.3-1.4-1.0-1.1-1.0-0.7-1.2-0.6-1.2-1.3-1.2-1.2-1.2-1.3-1.3-1.3-1.0
Std. dev. reaction times0.20.41.00.81.00.90.50.70.40.60.50.70.90.70.40.60.50.60.60.50.80.10.2
Reaction time trials completed1.32.43.11.51.61.61.51.61.61.61.31.71.41.81.51.51.61.61.61.51.51.61.3
Reaction time trials AUC1.22.22.81.41.51.51.51.61.61.51.21.61.41.71.51.51.51.51.51.41.51.61.3
Run reversals in cocaine runway, females0.20.20.90.80.50.70.50.30.20.40.90.20.60.10.30.50.30.40.40.50.30.30.3
Run reversals in cocaine runway, males0.70.71.10.91.00.90.90.71.00.91.00.70.80.70.90.90.90.90.90.80.60.80.4
Latency to leave start box in cocaine runway0.60.71.61.31.11.20.90.80.80.61.10.50.80.60.60.90.70.70.70.90.40.70.6
Latency to leave start box in cocaine runway, F0.30.30.80.80.50.70.70.60.50.30.90.20.40.30.40.70.50.50.50.70.20.60.5
Latency to leave start box in cocaine runway, M0.20.20.60.80.80.70.40.40.30.30.40.40.60.40.20.30.30.30.30.30.3-0.00.3
Std. dev. time between licks in bursts1.41.92.5-1.4-1.4-1.4-1.4-1.5-1.6-1.4-1.1-1.1-1.4-1.1-1.5-1.4-1.5-1.3-1.3-1.4-1.5-1.4-1.1
Total sessions with >9 infusions0.10.20.4-0.3-0.2-0.1-0.4-0.4-0.3-0.6-0.2-0.4-0.4-0.4-0.5-0.3-0.4-0.4-0.4-0.3-0.4-0.4-0.6
Short access day 1 total inactive lever presses0.10.10.40.0-0.20.1-0.3-0.3-0.3-0.6-0.1-0.5-0.2-0.4-0.5-0.2-0.4-0.4-0.4-0.2-0.2-0.4-0.2
Short access day 10 total inactive lever presses0.61.41.91.31.21.41.21.11.21.31.11.31.01.31.11.11.11.11.11.10.91.21.2
Short access day 1 total infusions0.10.10.50.20.20.30.0-0.0-0.0-0.30.3-0.60.0-0.6-0.20.1-0.1-0.1-0.10.1-0.1-0.0-0.7
Short access day 10 total infusions0.00.00.40.10.00.00.10.10.1-0.00.10.20.20.2-0.10.10.00.00.00.10.30.10.6
Short access total infusions0.10.20.4-0.2-0.1-0.1-0.4-0.4-0.4-0.6-0.0-0.5-0.3-0.5-0.6-0.3-0.4-0.4-0.4-0.3-0.4-0.4-0.6
Short access day 1 locomotion0.00.00.10.30.30.30.10.20.3-0.00.10.30.20.30.00.20.10.10.10.20.30.20.3
Short access day 10 total locomotion4.68.411.33.32.93.33.03.13.42.92.62.22.92.22.82.92.92.92.93.03.12.82.4
Short access total locomotion1.82.23.01.71.51.71.51.51.71.41.31.41.41.41.31.41.41.41.41.41.51.41.5
One hour access (0.3 mA shock)0.20.20.4-0.3-0.5-0.4-0.5-0.4-0.6-0.5-0.5-0.5-0.5-0.5-0.6-0.4-0.5-0.5-0.5-0.4-0.3-0.30.0
Compulsive drug intake0.10.21.7-0.00.10.1-0.2-0.2-0.2-0.1-0.0-0.6-0.2-0.6-0.2-0.2-0.1-0.1-0.1-0.2-0.4-0.3-1.3
One hour access (shock baseline)0.10.10.8-0.3-0.5-0.4-0.2-0.2-0.4-0.3-0.3-0.1-0.2-0.1-0.3-0.2-0.2-0.2-0.2-0.10.1-0.10.9
Social response proportion7.78.712.03.53.23.43.13.02.82.93.42.63.22.62.82.92.82.92.92.92.92.62.3
Social responses2.12.73.91.81.72.01.71.71.71.71.61.51.81.41.61.61.71.71.71.51.71.41.2
Social time0.70.91.61.11.11.21.01.00.90.90.91.00.90.90.90.91.00.90.90.90.90.80.3
Soleus weight0.00.10.4-0.2-0.3-0.2-0.2-0.4-0.3-0.2-0.1-0.4-0.4-0.5-0.2-0.2-0.1-0.2-0.2-0.0-0.6-0.0-0.3
Bone: stiffness0.40.71.4-1.0-0.9-1.2-0.8-0.5-0.8-0.9-1.2-1.0-0.8-1.0-0.9-0.7-0.9-0.9-0.9-0.7-0.4-0.8-0.4
Tibialis anterior weight3.311.214.93.93.73.73.53.43.33.33.63.23.43.13.23.63.33.23.23.53.23.22.2
Time to tail flick, vehicle, before self-admin0.00.00.0-0.2-0.2-0.20.10.10.1-0.0-0.0-0.2-0.0-0.20.20.10.10.10.10.1-0.10.10.1
Time to tail flick, vehicle, after self-admin0.20.30.8-0.6-0.8-0.8-0.4-0.3-0.3-0.5-0.5-0.8-0.4-0.9-0.3-0.3-0.5-0.5-0.5-0.3-0.3-0.20.3
Time to tail flick, test, before self-admin0.40.41.00.70.40.60.60.60.61.00.20.60.60.60.70.40.80.80.80.40.90.40.9
Time to tail flick, test, after self-admin1.31.32.21.51.31.41.31.41.11.11.10.41.20.31.11.41.11.11.11.41.31.20.4
Delta time to tail flick, vehicle, before/after SA0.10.10.1-0.2-0.3-0.3-0.2-0.1-0.3-0.2-0.2-0.3-0.1-0.3-0.2-0.1-0.3-0.3-0.3-0.20.0-0.10.3
Delta time to tail flick, test, before/after SA0.40.40.90.70.80.80.80.80.60.30.90.10.60.10.50.90.40.40.40.90.40.8-0.1
Tibia length0.51.32.2-1.4-1.5-1.5-1.1-1.1-1.0-1.2-1.0-1.2-1.0-1.2-1.1-1.0-1.2-1.3-1.3-0.9-0.8-0.90.0
Ambulatory time before self-admin0.20.20.6-0.4-0.4-0.4-0.4-0.4-0.4-0.6-0.4-0.8-0.4-0.7-0.4-0.4-0.3-0.3-0.3-0.4-0.4-0.7-0.7
Ambulatory time after self-admin1.21.43.2-1.0-0.9-1.0-1.1-1.0-1.1-1.3-1.0-1.7-1.1-1.7-1.1-0.9-1.0-1.0-1.0-0.9-1.1-1.1-1.8
Bone: tissue strength0.10.10.3-0.4-0.4-0.6-0.3-0.3-0.3-0.3-0.4-0.3-0.2-0.4-0.2-0.4-0.3-0.3-0.3-0.4-0.1-0.50.4
Total heroin consumption0.20.21.10.30.10.20.40.50.50.40.40.30.40.20.40.50.30.30.30.50.50.41.0
Bone: trabecular number0.00.00.1-0.1-0.1-0.1-0.1-0.10.00.1-0.3-0.1-0.1-0.10.0-0.10.10.10.1-0.1-0.1-0.0-0.2
Bone: trabecular spacing0.20.30.80.50.50.50.50.70.60.40.40.40.80.40.50.60.50.40.40.60.90.30.8
Bone: trabecular thickness2.53.24.32.11.81.91.91.71.71.91.81.71.71.71.81.71.81.81.81.81.61.81.5
Bone: trabecular tissue density0.20.30.90.60.90.90.50.60.60.50.50.50.60.50.40.60.50.50.50.60.60.3-0.7
Water consumed over 24 hours2.73.76.3-2.1-1.7-1.7-2.0-1.6-1.6-2.0-2.3-2.1-1.7-2.1-1.9-1.8-1.8-2.0-2.0-1.8-1.3-2.0-2.5
Number of responses in last shaping day0.00.00.20.20.30.30.10.30.3-0.00.2-0.10.0-0.1-0.10.3-0.0-0.0-0.00.20.10.4-0.4