Hub : Genes

Helz

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Helz 0.23 0.11 2.5e-04 0.1 0.15 0.19 0.14 2.7e-03 2.1e-04 3.0e-05 3.3e-04
2 Brain gene expression Helz 0.14 0.06 5.6e-17 0.16 0.17 0.16 0.17 1.4e-14 7.0e-16 8.4e-15 5.9e-16
3 BLA gene expression Helz 0.45 0.13 0.0e+00 0.4 0.36 0.4 0.4 1.7e-22 3.4e-20 1.8e-22 1.1e-22
4 NAcc gene expression Helz 0.1 0.04 0.0e+00 0.16 0.14 0.15 0.16 1.2e-23 2.9e-21 3.2e-22 7.9e-23
5 BLA alternative polyA XM_063268757.1 0.07 0.06 4.5e-03 0.01 0.04 0.03 0.02 1.0e-01 3.5e-03 1.5e-02 2.7e-02
6 PL mRNA stability Helz 0.04 0.02 9.7e-05 0.04 0.04 0.03 0.03 2.4e-05 7.9e-05 7.1e-04 1.3e-04
7 pVTA gene expression Helz 0.22 0.09 2.9e-14 0.21 0.18 0.2 0.21 1.5e-16 1.1e-14 1.1e-15 1.4e-16
8 BLA alternative polyA XM_063268757.1 0.07 0.05 2.6e-03 0.02 0.04 0.02 0.02 1.9e-02 4.3e-03 2.3e-02 2.2e-02
9 NAcc mRNA stability Helz 0.02 0.02 2.7e-03 0.01 0.01 0.01 0.01 3.8e-03 1.7e-03 1.9e-03 3.6e-03
10 OFC gene expression Helz 0.26 0.11 7.1e-05 0.13 0.14 0.14 0.13 5.5e-04 4.1e-04 3.9e-04 6.7e-04
11 Adipose alternative polyA XM_063268757.1 0.11 0.05 2.2e-10 0.08 0.09 0.08 0.08 3.8e-09 1.1e-09 3.9e-09 2.0e-09
12 Adipose alternative polyA NM_001105848.2 0.11 0.05 2.3e-10 0.08 0.09 0.08 0.08 3.4e-09 1.1e-09 3.8e-09 2.1e-09
13 PL gene expression Helz 0.36 0.1 0.0e+00 0.4 0.4 0.41 0.4 1.7e-46 7.3e-47 3.4e-48 4.3e-47
14 IC gene expression Helz 0.27 0.1 1.2e-10 0.2 0.18 0.22 0.24 1.0e-08 3.4e-08 1.0e-09 1.7e-10
15 Adipose alternative polyA NM_001105848.2 0.12 0.05 1.1e-10 0.08 0.09 0.08 0.09 2.2e-09 1.1e-09 3.1e-09 7.4e-10
16 Adipose alternative polyA XM_063268757.1 0.12 0.05 1.5e-10 0.08 0.08 0.08 0.09 2.6e-09 1.6e-09 3.7e-09 8.3e-10
17 BLA mRNA stability Helz 0.13 0.07 3.6e-05 0.05 0.07 0.05 0.08 7.9e-04 2.0e-04 1.1e-03 5.8e-05
18 BLA isoform ratio XM_006247562.5 0.11 0.06 4.9e-04 0.05 0.06 0.01 0.05 1.8e-03 4.5e-04 7.1e-02 1.5e-03
19 Adipose isoform ratio XM_063268761.1 0.03 0.02 1.8e-03 0.02 0.03 0.03 0.02 1.8e-03 6.5e-04 7.1e-04 2.1e-03
20 Adipose isoform ratio NM_001105848.2 0.14 0.06 2.9e-10 0.08 0.07 0.08 0.08 1.5e-09 2.8e-08 9.0e-09 4.7e-09
21 Brain alternative polyA NM_001105848.2 0.04 0.02 6.9e-04 0.03 0.02 0.02 0.02 5.2e-04 3.7e-03 8.1e-03 5.0e-03
22 Brain alternative polyA XM_063268757.1 0.03 0.02 3.6e-03 0.02 0.01 0 0.01 7.2e-03 4.5e-02 1.1e-01 3.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Bone: apparent density0.40.81.71.1-0.7-0.60.7-0.90.5-0.1-0.9-0.90.6-1.11.10.6-0.61.2-1.2-0.5-1.3-1.0-1.2-0.90.9
Area under the delay curve0.10.21.00.10.40.4-0.10.3-0.70.90.20.2-0.4-0.50.5-0.30.40.5-0.50.5-0.7-0.0-1.00.0-0.0
BMI with tail1.13.815.43.4-3.0-2.61.90.41.6-3.90.3-2.11.40.9-0.82.3-1.2-0.50.5-3.70.41.81.30.2-0.2
BMI without tail1.36.727.64.5-4.0-3.72.8-0.42.7-5.3-0.5-2.92.50.1-0.03.2-1.90.2-0.2-4.8-0.21.51.1-0.20.2
Body weight2.410.426.05.0-4.6-4.43.9-2.03.7-5.1-2.1-3.93.6-1.91.94.1-3.21.8-1.7-4.7-2.1-0.5-0.6-1.51.5
Weight adjusted by age0.51.33.4-1.01.31.3-1.11.3-1.51.71.31.0-1.81.0-1.0-1.41.1-0.90.91.40.80.9-0.10.7-0.7
Bone surface4.07.911.72.7-2.6-2.42.7-3.32.7-1.6-3.3-2.92.4-3.23.12.4-2.73.4-3.4-1.8-3.1-3.1-3.2-2.52.5
Bone volume2.95.98.92.6-2.2-2.12.3-2.62.2-1.3-2.6-2.51.9-2.82.82.1-2.33.0-3.0-1.5-2.9-2.5-2.9-2.12.1
Breakpoint value in progressive ratio session0.91.72.7-1.10.81.2-1.31.2-1.30.81.31.0-1.61.6-1.6-1.31.2-1.21.21.01.61.41.01.6-1.6
Number of licking bursts0.00.00.2-0.2-0.0-0.0-0.0-0.30.1-0.0-0.20.20.4-0.30.30.1-0.20.2-0.20.20.0-0.1-0.20.2-0.2
Context. condit. distance diff. score0.00.00.10.3-0.10.0-0.10.3-0.0-0.10.2-0.1-0.30.1-0.10.10.10.1-0.1-0.1-0.00.1-0.3-0.10.1
Locomotion velocity, session 10.20.20.70.8-0.6-0.50.5-0.60.5-0.4-0.6-0.70.5-0.50.50.3-0.40.3-0.3-0.4-0.5-0.4-0.1-0.30.3
Locomotion distance, session 10.10.21.11.1-0.5-0.50.6-0.30.2-0.3-0.2-0.50.1-0.30.30.3-0.20.4-0.4-0.4-0.30.1-0.40.2-0.2
Locomotion velocity, session 20.30.31.10.1-0.6-0.50.5-1.10.6-0.6-0.8-0.40.4-0.40.40.1-0.50.8-0.7-0.10.3-0.3-0.70.6-0.6
Locomotion distance, session 20.20.21.60.00.10.2-0.2-0.2-0.1-0.10.00.3-0.10.1-0.1-0.40.40.3-0.30.30.60.5-0.41.3-1.3
Locomotion velocity, session 32.02.24.1-0.51.21.5-1.61.4-1.81.21.51.4-1.71.2-1.2-1.71.9-1.31.41.21.41.80.92.0-2.0
Locomotion distance, session 30.20.30.9-0.00.40.7-0.60.0-0.60.90.10.3-0.7-0.20.2-0.70.60.2-0.21.0-0.1-0.0-0.60.5-0.5
Stereotopy head waving bouts, day 31.31.53.2-0.91.21.1-1.11.6-1.41.21.51.0-1.81.2-1.2-1.11.3-1.41.41.00.91.31.11.0-1.0
Stereotopy head waving duration, day 31.31.63.1-1.01.41.3-1.21.5-1.51.51.41.3-1.81.0-0.9-1.31.4-1.21.21.40.71.20.71.2-1.2
Locomotion velocity, session 70.50.52.0-0.20.10.2-0.30.7-0.4-0.00.70.1-0.71.1-1.1-0.30.2-1.31.3-0.10.90.61.4-0.00.0
Locomotion distance, session 70.00.00.10.2-0.1-0.10.0-0.20.2-0.2-0.2-0.20.3-0.20.20.2-0.20.0-0.0-0.1-0.3-0.20.0-0.10.1
Stereotopy head waving bouts, day 72.52.94.5-1.61.71.8-1.71.6-2.11.71.71.8-2.11.6-1.6-2.01.9-1.41.41.71.81.60.71.8-1.8
Stereotopy head waving duration, day 74.05.07.5-2.42.42.5-2.41.9-2.72.42.02.5-2.61.9-1.9-2.72.4-1.91.92.42.21.71.12.1-2.1
Locomotion velocity, session 80.30.30.90.5-0.5-0.40.5-0.70.4-0.0-0.7-0.80.1-0.30.20.2-0.50.6-0.6-0.2-0.4-0.9-0.7-1.01.0
Locomotion distance, session 80.10.10.30.5-0.4-0.30.3-0.50.4-0.5-0.4-0.40.2-0.30.20.2-0.20.5-0.5-0.3-0.0-0.1-0.5-0.10.1
Degree of sensitization distance0.50.51.00.6-0.7-1.00.9-0.50.9-1.0-0.6-0.80.8-0.30.31.0-1.00.3-0.3-1.0-0.6-0.50.0-0.90.9
Degree of sensitization stereotypy2.52.74.8-1.41.51.6-1.71.4-1.91.21.61.8-1.81.7-1.7-2.01.8-1.31.31.42.21.80.62.0-2.0
Conditioned locomotion0.10.10.30.6-0.4-0.40.4-0.10.2-0.3-0.1-0.40.20.1-0.10.4-0.4-0.30.3-0.4-0.1-0.10.5-0.40.4
Cocaine response after cond. corrected0.30.41.4-1.20.90.8-0.60.3-0.61.00.30.8-0.70.1-0.1-0.70.40.00.01.00.1-0.1-0.40.4-0.4
Cocaine response after cond. not corrected0.60.83.1-1.81.31.2-0.90.2-0.91.50.31.2-1.10.2-0.2-1.20.60.1-0.11.50.6-0.1-0.70.5-0.5
Cocaine response before conditioning0.20.20.9-0.50.40.5-0.4-0.1-0.40.80.10.5-0.6-0.10.0-0.70.40.4-0.40.90.50.1-0.90.3-0.3
Saline control response0.60.84.80.9-1.3-1.10.80.01.0-2.20.1-0.71.10.5-0.50.9-0.5-0.20.2-1.80.60.80.80.3-0.3
Bone: connectivity density0.91.42.21.3-1.0-0.91.1-1.31.0-0.5-1.4-1.31.0-1.31.30.9-1.01.5-1.5-0.8-1.5-1.4-1.5-1.01.0
Bone: cortical apparent density2.43.78.7-0.71.61.6-1.82.9-2.01.02.81.6-1.82.2-2.2-1.52.1-2.22.10.71.62.71.91.8-1.8
Bone: cortical area1.11.87.62.8-1.9-1.61.4-0.91.3-1.8-0.8-1.41.1-1.11.11.5-1.10.9-0.9-1.7-0.9-0.0-0.6-1.01.0
Bone: cortical porosity2.42.65.61.0-1.6-1.61.8-2.41.7-1.3-2.1-1.41.8-1.81.81.4-1.91.7-1.7-0.7-1.0-1.7-1.5-1.31.3
Bone: cortical porosity2.12.34.21.4-1.6-1.61.7-2.01.6-1.3-1.8-1.31.6-1.81.81.4-1.61.8-1.8-0.8-1.1-1.3-1.7-1.01.0
Bone: cortical thickness4.47.320.8-0.21.51.8-2.43.7-2.60.53.82.4-2.53.1-3.0-2.03.0-3.03.00.63.24.62.62.6-2.6
Bone: cortical thickness1.82.36.80.20.40.5-1.02.0-1.0-0.42.01.1-0.91.9-1.9-0.71.3-2.12.1-0.32.02.62.31.3-1.3
Bone: cortical tissue density2.33.78.6-0.81.61.6-1.72.9-2.01.02.81.6-1.82.2-2.2-1.52.1-2.22.20.71.62.71.91.8-1.8
Condit. Reinf. active minus inactive responses2.83.25.81.3-1.5-1.82.1-2.32.0-1.1-2.1-1.31.7-2.42.41.6-2.02.3-2.2-0.6-1.7-1.6-2.2-0.70.7
Condit. Reinf. active-inactive response ratio1.01.02.30.3-0.5-0.71.0-1.41.2-0.2-1.3-0.60.8-1.51.50.7-1.11.3-1.30.1-1.2-1.3-1.3-0.50.5
Condit. Reinf. active responses3.54.46.41.9-2.0-2.32.5-2.52.3-1.5-2.3-1.81.8-2.52.52.1-2.42.5-2.5-1.1-1.9-1.8-2.5-1.31.3
Condit. Reinf. inactive responses1.62.03.31.8-1.6-1.71.8-1.31.3-1.2-1.3-1.60.9-1.31.31.5-1.51.6-1.6-1.2-1.2-0.9-1.8-1.21.2
Incentive salience index mean1.62.03.21.2-1.5-1.61.8-1.81.6-1.2-1.6-1.21.3-1.71.71.4-1.71.6-1.6-0.8-1.1-1.2-1.5-0.70.7
Condit. Reinf. lever presses0.10.10.50.3-0.5-0.50.4-0.10.2-0.70.0-0.2-0.10.3-0.30.3-0.3-0.30.3-0.40.70.40.30.0-0.0
Condit. Reinf. active minus inactive responses3.85.810.22.5-2.1-2.12.1-3.12.5-1.6-2.8-1.92.4-3.23.21.9-2.13.1-3.2-1.1-2.3-2.1-3.1-1.21.2
Condit. Reinf. active-inactive response ratio1.42.24.90.8-1.1-1.11.2-2.21.6-0.8-2.0-0.91.7-2.12.11.1-1.42.0-2.0-0.4-1.3-1.7-1.9-0.80.8
Condit. Reinf. active responses5.88.312.33.4-2.7-2.82.9-3.53.0-2.2-3.3-2.62.9-3.43.42.5-2.73.4-3.4-1.9-2.6-2.4-3.1-1.91.9
Condit. Reinf. inactive responses2.63.910.63.3-2.3-2.42.3-1.92.1-2.2-1.8-2.21.8-1.81.82.0-1.92.0-2.0-2.0-1.6-1.0-1.6-1.31.3
Condit. Reinf. lever presses2.63.86.52.3-2.2-2.32.2-2.42.2-2.3-2.1-1.62.5-2.22.21.9-1.92.0-2.0-1.7-1.2-1.1-1.6-0.50.5
Condit. Reinf. lever reinforcers received5.37.511.43.2-2.6-2.72.8-3.42.9-2.2-3.1-2.42.9-3.33.32.4-2.63.2-3.2-1.8-2.5-2.4-2.8-1.81.8
Conditioned reinforcement - actives0.10.41.80.5-0.5-0.50.3-0.71.2-0.9-0.6-0.11.3-0.80.80.30.00.5-0.5-0.5-0.20.10.20.5-0.5
Conditioned reinforcement - inactives0.30.92.11.4-1.4-1.11.1-0.81.0-1.1-0.9-1.31.1-0.60.60.9-0.90.8-0.8-1.3-0.6-0.4-0.5-0.70.7
Conditioned locomotion1.82.75.12.2-2.1-1.81.6-1.52.3-2.1-1.5-1.82.1-1.51.51.8-1.41.5-1.5-2.1-1.4-0.8-0.6-1.01.0
Patch foraging indifference point 0 sec3.39.315.43.9-3.5-3.73.7-2.93.7-3.3-2.9-3.13.3-3.13.13.4-3.12.9-2.9-3.0-2.9-1.8-2.0-1.61.6
Patch foraging indifference point AUC0.30.72.31.5-1.1-0.90.9-0.70.7-0.8-0.7-1.10.9-0.60.60.7-0.50.9-0.9-1.1-0.7-0.5-0.5-0.80.8
Delay disc. indifference point, 0s delay0.80.93.0-1.11.31.2-0.90.9-1.51.70.81.0-1.10.6-0.6-1.21.1-0.50.51.10.40.4-0.10.7-0.7
Delay disc. indifference point, 16s delay0.10.10.40.40.00.0-0.10.1-0.50.20.10.10.2-0.60.60.10.20.5-0.40.0-0.70.2-0.60.0-0.0
Delay disc. indifference point, 2s delay1.21.44.60.8-0.6-0.81.2-0.70.90.1-0.9-1.00.3-1.41.40.9-0.91.7-1.7-0.3-1.8-1.2-2.1-1.21.2
Delay disc. indifference point, 24s delay0.71.13.82.0-1.3-1.31.1-0.50.5-1.2-0.6-1.21.2-1.11.11.2-0.70.7-0.7-1.3-1.3-0.2-0.4-0.70.7
Delay disc. indifference point, 4s delay1.01.13.3-1.11.41.5-1.20.7-1.21.80.71.3-1.10.3-0.3-1.41.3-0.40.41.50.40.4-0.40.7-0.7
Delay disc. indifference point, 8s delay0.30.51.5-0.30.80.8-0.61.1-1.21.20.90.5-1.00.3-0.3-0.70.8-0.40.40.7-0.20.5-0.20.3-0.3
Indifference point function ln k0.10.20.70.10.50.2-0.20.6-0.30.10.70.6-0.90.3-0.3-0.20.3-0.40.40.50.50.8-0.10.7-0.7
Indifference point function log k0.10.20.70.10.50.2-0.20.6-0.30.10.70.6-0.90.3-0.3-0.20.3-0.40.40.50.50.8-0.10.7-0.7
Patch foraging total patch changes 0 sec2.98.614.83.8-3.3-3.53.5-2.93.4-3.1-2.8-3.13.2-3.03.03.2-2.92.8-2.8-2.9-2.9-1.9-1.9-1.71.7
Patch foraging total patch changes 12 sec5.87.810.43.0-3.2-3.23.2-2.93.1-2.6-3.0-3.13.1-2.82.83.0-3.02.7-2.7-2.6-2.9-2.4-1.8-2.02.0
Patch foraging total patch changes 18 sec1.02.35.52.3-2.1-1.91.8-1.41.7-1.9-1.3-1.91.5-1.11.11.6-1.41.5-1.5-1.8-1.1-0.6-1.1-0.60.6
Patch foraging total patch changes 24 sec1.34.510.93.3-2.7-2.62.6-1.82.1-2.4-1.8-2.52.1-1.92.02.2-1.92.0-2.0-2.4-1.9-1.0-1.3-1.41.4
Patch foraging total patch changes 6 sec4.37.310.93.1-3.2-3.33.3-2.83.0-2.8-2.7-2.83.0-2.82.83.0-2.92.6-2.6-2.6-2.5-1.8-1.8-1.51.5
Patch foraging time to switch 0 sec0.31.13.9-2.01.11.0-1.10.8-0.80.80.81.1-0.70.9-0.9-0.80.8-1.11.21.10.80.51.11.2-1.2
Patch foraging water rate 0 sec1.24.510.73.3-2.5-2.62.5-1.82.2-2.4-1.8-2.52.1-1.71.72.2-2.11.8-1.8-2.6-1.8-1.2-1.3-1.91.9
Patch foraging water rate 12 sec0.10.21.00.30.10.0-0.20.5-0.3-0.30.50.5-0.10.3-0.3-0.20.4-0.40.4-0.30.61.00.40.8-0.8
Patch foraging water rate 18 sec0.10.30.80.9-0.6-0.80.7-0.10.8-0.9-0.0-0.30.3-0.30.40.7-0.60.4-0.4-0.7-0.20.4-0.50.0-0.0
Patch foraging water rate 24 sec0.10.11.0-0.10.1-0.10.10.2-0.20.20.20.0-0.6-0.10.10.1-0.20.5-0.50.5-0.20.1-1.00.4-0.4
Patch foraging water rate 6 sec0.10.20.60.8-0.3-0.30.10.6-0.2-0.50.5-0.1-0.50.4-0.40.20.0-0.20.1-0.50.30.8-0.20.2-0.2
Seeking ratio, delayed vs. immediate footshock0.10.10.40.5-0.0-0.00.00.5-0.6-0.10.4-0.0-0.10.3-0.30.00.3-0.40.4-0.30.10.50.50.1-0.1
Distance traveled before self-admin0.81.74.5-1.61.71.8-1.60.7-1.61.90.81.6-1.20.4-0.4-1.71.5-0.00.02.10.70.5-0.61.4-1.4
Distance traveled after self-admin0.20.31.0-0.60.60.5-0.3-0.50.10.6-0.30.60.1-0.60.6-0.70.40.7-0.71.0-0.0-0.3-1.00.6-0.6
Extensor digitorum longus weight1.04.011.0-1.31.21.2-1.73.0-1.80.32.61.3-1.93.3-3.3-1.11.5-2.62.6-0.32.42.32.40.3-0.3
Bone: elastic displacement1.21.52.6-0.81.11.1-1.21.4-1.10.81.51.4-1.41.2-1.2-1.21.4-1.11.10.91.51.60.91.2-1.2
Bone: elastic work0.30.41.61.3-0.9-0.80.60.30.4-1.10.3-0.60.10.4-0.40.6-0.3-0.20.2-1.20.40.80.4-0.40.4
Bone: endosteal estimation13.933.951.94.6-5.5-5.76.2-7.26.3-4.3-7.1-5.95.8-6.36.35.6-6.56.0-6.0-3.9-5.8-6.6-4.8-5.15.1
Bone: endosteal perimeter13.132.045.45.0-5.2-5.25.7-6.75.8-3.6-6.7-5.85.3-6.36.35.3-6.06.2-6.2-3.4-6.1-6.4-5.4-5.35.3
Epididymis fat weight0.21.25.61.2-1.6-1.41.00.01.0-2.4-0.1-1.21.10.3-0.31.5-1.0-0.70.7-2.0-0.10.51.5-0.10.1
Delta time in closed arm before/after self-admin0.10.10.2-0.30.10.20.00.2-0.20.50.1-0.2-0.50.3-0.30.0-0.2-0.20.30.2-0.1-0.30.2-0.30.3
Delta time in open arm before/after self-admin0.40.41.3-0.50.80.7-0.70.6-1.10.90.60.7-0.80.4-0.3-0.80.9-0.30.20.80.30.6-0.20.6-0.6
Diff in mean of infusions in LGA sessions1.62.84.7-1.41.21.4-1.81.9-1.30.71.91.6-1.32.1-2.1-1.41.7-2.02.00.72.12.02.21.6-1.6
Delay discount exponential model param0.20.21.2-0.4-0.1-0.1-0.1-0.00.3-0.60.00.10.10.7-0.8-0.0-0.1-0.70.7-0.31.00.31.10.3-0.3
Extinction: sum of active levers before priming0.20.40.90.30.10.2-0.30.9-0.20.10.80.2-0.90.9-0.9-0.20.3-0.90.9-0.10.60.90.90.2-0.2
Active lever presses in extinction session 60.80.81.81.1-1.2-1.11.1-0.81.2-1.1-0.8-0.91.3-0.80.81.0-0.90.9-0.9-0.9-0.7-0.4-0.3-0.60.6
Bone: final force1.42.33.81.9-1.7-1.71.8-1.41.5-1.3-1.4-1.61.4-1.61.61.8-1.61.5-1.5-1.3-1.5-1.0-1.3-1.31.3
Bone: final moment1.52.53.92.0-1.7-1.81.9-1.51.6-1.4-1.5-1.61.4-1.71.71.8-1.71.5-1.5-1.4-1.6-1.0-1.3-1.31.3
Food consumed during 24 hour testing period0.71.56.01.6-1.9-1.81.3-0.51.2-2.5-0.5-1.51.40.0-0.01.5-1.0-0.20.2-2.3-0.20.30.9-0.40.4
Glucose1.72.84.0-1.61.81.9-1.91.7-1.91.51.81.8-1.71.6-1.5-2.02.0-1.11.01.61.71.70.51.8-1.8
Heart weight0.40.61.3-0.20.90.8-0.80.8-1.10.70.81.0-0.70.4-0.3-0.91.1-0.60.60.80.51.10.31.1-1.1
Delay discount hyperbolic model param0.20.21.4-0.3-0.1-0.1-0.2-0.00.3-0.70.00.10.30.7-0.7-0.0-0.1-0.70.7-0.31.00.31.20.4-0.4
Intermittent access intake day 1-15 change0.00.21.0-0.30.1-0.0-0.0-0.60.20.1-0.6-0.00.4-0.10.10.0-0.2-0.50.5-0.1-0.0-0.81.0-0.70.7
Intermittent access intake escalation0.10.30.90.2-0.4-0.50.4-0.80.5-0.3-0.8-0.50.6-0.40.40.4-0.6-0.00.0-0.4-0.3-0.90.5-0.90.9
Intermittent access intake escalation 20.40.72.20.5-0.6-0.70.6-1.11.0-0.6-1.2-0.81.0-0.40.40.6-0.80.0-0.0-0.9-0.5-1.30.8-1.51.5
Intermitt. access day 1 inactive lever presses0.11.22.71.5-1.6-1.31.3-1.00.8-1.4-1.0-1.60.8-0.40.41.2-1.41.0-1.0-1.3-0.4-0.6-1.2-0.90.9
Intermitt. access day 15 inactive lever presses0.20.92.81.1-1.5-1.21.0-0.40.7-1.5-0.5-1.40.80.2-0.31.2-1.00.1-0.2-1.7-0.1-0.30.3-1.21.2
Intermitt. access escalation Index0.82.65.5-2.22.22.2-2.10.8-1.62.01.02.3-0.90.7-0.7-2.22.0-1.11.11.81.40.81.01.6-1.6
Intermittent access day 1 total infusions0.30.91.61.3-1.2-1.11.1-0.81.0-1.2-0.6-0.70.7-1.01.00.7-0.61.3-1.2-0.6-0.50.2-1.30.6-0.6
Intermittent access day 15 total infusions0.61.32.01.4-1.4-1.41.3-1.41.4-1.4-1.3-1.11.4-1.41.41.2-1.11.0-1.0-1.1-1.0-0.7-0.5-0.40.4
Intermittent access terminal intake (last 3 days)1.93.34.91.9-2.0-2.02.0-2.22.0-1.8-2.2-1.92.1-2.02.01.8-1.81.6-1.6-1.7-1.8-1.6-0.9-1.31.3
Intermittent access total infusions2.73.24.92.2-2.1-2.02.1-2.01.9-1.8-1.8-1.81.8-2.12.11.7-1.62.0-2.0-1.5-1.7-1.1-1.6-0.70.7
Intermittent access day 1 locomotion1.83.36.62.6-2.5-2.22.2-1.62.0-2.6-1.5-1.91.9-1.61.61.9-1.61.9-1.9-2.1-1.2-0.3-1.6-0.30.3
Intermittent access day 15 total locomotion1.76.610.93.2-3.3-3.13.0-2.53.2-3.2-2.4-2.82.6-2.32.33.0-2.72.3-2.3-2.8-2.0-1.4-1.5-1.41.4
Intermittent access total locomotion8.39.917.94.2-4.1-3.93.8-2.93.5-4.1-2.8-3.43.2-2.82.83.6-3.13.0-3.0-3.6-2.4-1.3-2.3-1.51.5
Intermittent access standard deviation0.20.91.71.3-1.1-0.90.9-1.00.9-0.8-1.0-1.20.8-0.90.90.9-0.90.9-0.9-0.9-1.1-1.0-0.5-1.11.1
Left kidney weight0.00.31.50.6-0.2-0.20.20.2-0.1-0.80.30.30.2-0.00.1-0.00.20.3-0.3-0.10.41.0-0.31.2-1.2
Right kidney weight0.00.21.40.5-0.1-0.10.00.3-0.4-0.60.40.30.00.00.0-0.20.4-0.10.1-0.10.31.0-0.01.2-1.2
Cocaine induced anxiety0.10.10.5-0.30.40.2-0.1-0.1-0.10.50.10.5-0.1-0.30.3-0.30.10.6-0.60.60.10.1-0.70.5-0.5
Post-drug Anxiety0.20.20.5-0.40.50.4-0.30.7-0.20.40.70.5-0.70.4-0.4-0.40.30.0-0.00.50.30.6-0.30.6-0.6
Baseline Anxiety0.50.82.5-0.30.30.4-0.71.4-0.2-0.31.20.3-0.41.3-1.3-0.30.8-1.31.3-0.30.81.31.60.4-0.4
Tail length1.58.214.13.4-3.5-3.53.3-2.83.5-3.8-2.8-3.23.2-2.52.53.3-2.92.3-2.3-3.3-2.4-1.7-1.1-2.02.0
Length with tail1.87.810.12.8-2.8-2.93.1-3.13.0-2.3-3.1-3.02.8-3.13.12.8-2.92.7-2.7-2.1-3.2-2.8-2.0-2.42.4
Length without tail0.10.61.80.5-0.5-0.50.7-0.80.40.0-0.9-0.80.6-1.01.00.6-0.80.5-0.5-0.2-1.4-1.3-0.5-1.11.1
Times rat made contact with spout0.30.41.00.5-0.8-0.60.3-0.80.7-1.0-0.8-0.60.9-0.40.40.6-0.60.3-0.3-0.8-0.1-0.50.0-0.60.6
Lifetime Intake2.53.16.12.5-2.2-2.12.1-1.71.8-2.1-1.6-1.81.7-1.81.81.8-1.52.0-1.9-1.7-1.5-0.6-1.6-0.40.4
Liver weight, left2.33.96.02.1-2.2-1.92.1-2.42.1-1.6-2.4-2.22.0-2.02.01.9-2.21.7-1.7-1.5-1.7-2.1-1.4-1.91.9
Liver weight, right0.61.13.2-0.30.30.4-0.70.9-0.7-0.21.11.0-0.41.0-1.0-0.81.0-1.11.10.11.51.81.11.8-1.8
Locomotor activity0.91.43.91.6-1.4-1.41.1-1.21.3-2.0-0.8-0.61.9-1.11.10.8-0.51.3-1.3-1.2-0.10.5-1.01.0-1.0
Locomotor testing distance0.40.92.71.6-1.1-1.10.9-0.91.0-1.6-0.5-0.41.2-0.70.70.5-0.20.9-1.0-0.90.20.7-0.71.1-1.1
Locomotor testing rearing0.20.62.71.1-1.1-1.10.8-0.70.8-1.6-0.5-0.60.70.3-0.30.6-0.7-0.10.1-1.20.90.30.50.1-0.1
Locomotion in novel chamber0.30.41.9-0.70.70.6-0.30.3-0.81.40.30.3-1.30.1-0.1-0.70.30.3-0.31.3-0.1-0.3-1.1-0.10.1
Locomotion in novel chamber post-restriction1.03.06.01.3-1.3-1.62.0-1.61.5-0.2-1.7-1.90.7-2.01.91.6-1.91.8-1.8-0.5-2.4-2.2-2.1-2.02.0
Fecal boli incidents, locomotor time 10.10.20.7-0.80.60.6-0.40.2-0.60.80.10.3-0.6-0.10.1-0.30.1-0.00.00.8-0.3-0.5-0.3-0.10.1
Change in fecal boli incidents, locomotor task0.30.40.80.6-0.4-0.50.5-0.50.8-0.5-0.6-0.50.9-0.70.70.6-0.50.3-0.3-0.7-0.9-0.60.3-0.50.5
Time >=10cm from walls, locomotor time 11.11.43.4-1.91.41.2-1.20.7-1.21.30.81.4-1.40.7-0.7-1.31.1-0.70.71.71.00.50.21.4-1.4
Bouts of movement, locomotor time 10.20.20.8-0.1-0.2-0.20.10.8-0.0-0.60.70.0-0.20.9-0.90.4-0.3-0.50.5-0.60.60.80.50.0-0.0
Total resting periods, locomotor time 10.20.20.6-0.1-0.1-0.10.10.7-0.1-0.40.6-0.1-0.30.8-0.80.4-0.3-0.50.4-0.50.40.50.4-0.20.2
Rest time, locomotor task time 10.30.51.6-1.00.60.7-0.70.8-0.80.80.60.3-1.31.0-1.0-0.40.1-0.80.80.50.50.00.5-0.40.4
Distance moved, locomotor task time 10.10.20.90.9-0.7-0.60.5-0.10.5-0.9-0.1-0.60.60.0-0.00.5-0.2-0.20.1-0.9-0.10.30.50.1-0.1
Vertical activity count, locomotor time 10.00.10.40.7-0.4-0.40.4-0.1-0.1-0.4-0.1-0.40.5-0.10.10.2-0.1-0.10.1-0.5-0.10.00.20.1-0.1
Time >=10cm from walls, locomotor time 20.41.23.6-1.20.50.7-0.70.9-1.00.20.90.6-1.21.9-1.9-0.80.5-1.51.50.31.80.91.30.5-0.5
Bouts of movement, locomotor time 20.41.33.3-0.20.30.5-0.81.7-0.9-0.41.50.5-0.61.8-1.8-0.40.8-1.41.4-0.61.51.71.50.6-0.6
Total resting periods, locomotor time 20.31.32.9-0.50.50.7-0.91.7-1.0-0.01.60.8-0.91.7-1.7-0.51.0-1.31.3-0.21.51.71.10.9-0.9
Rest time, locomotor task time 23.35.59.3-3.12.92.8-2.82.4-2.73.02.32.5-3.01.9-1.9-2.52.4-1.61.62.91.51.40.62.0-2.0
Distance moved, locomotor task time 20.60.82.90.8-1.0-0.70.6-0.10.8-1.4-0.2-0.80.80.9-0.90.6-0.5-1.01.0-1.50.90.41.7-0.50.5
Vertical activity count, locomotor time 20.92.16.02.0-2.0-1.81.6-1.21.6-2.4-1.2-1.72.0-0.30.21.5-1.4-0.20.2-2.5-0.0-0.41.2-1.11.1
Light reinforcement 10.21.03.81.3-0.7-0.4-0.01.2-0.0-1.31.2-0.10.00.8-0.80.40.4-1.01.0-1.10.62.01.31.3-1.3
Light reinforcement 20.10.31.21.0-0.3-0.1-0.11.1-0.3-0.20.9-0.3-0.60.3-0.30.20.4-0.10.1-0.3-0.41.0-0.30.5-0.5
Bone: marrow area13.332.750.24.5-5.4-5.66.1-7.16.2-4.2-7.0-5.85.7-6.26.15.5-6.45.9-5.8-3.8-5.7-6.5-4.7-5.15.1
Bone: maximum diameter4.99.815.13.3-2.8-2.83.1-3.63.1-1.8-3.5-3.02.7-3.93.92.8-3.03.6-3.6-1.6-3.6-3.2-3.3-2.82.8
Bone: maximum force2.34.59.13.0-2.3-2.42.4-2.02.3-2.0-1.9-2.21.9-2.32.42.4-2.12.1-2.1-1.9-2.2-1.2-1.8-1.41.4
Bone: maximum moment2.64.89.33.1-2.4-2.52.5-2.02.4-2.1-2.0-2.32.0-2.42.42.5-2.32.1-2.1-2.0-2.3-1.3-1.8-1.51.5
Mean time between licks in bursts0.00.30.80.7-0.7-0.60.4-0.10.8-0.8-0.2-0.70.3-0.20.20.9-0.60.2-0.1-0.9-0.6-0.20.3-0.40.4
Mean num. licks in bursts0.00.10.40.6-0.3-0.20.10.00.3-0.5-0.1-0.40.00.1-0.10.20.1-0.10.1-0.6-0.20.00.3-0.40.4
Cd content in liver1.01.24.0-2.01.51.2-1.00.8-1.11.80.60.9-1.20.9-0.9-0.80.3-1.21.21.20.4-0.51.0-0.80.8
Co content in liver1.21.42.4-1.61.21.3-1.21.3-1.41.51.21.1-1.41.1-1.1-1.01.0-1.51.51.30.80.61.30.6-0.6
Cu content in liver0.10.20.40.2-0.4-0.40.4-0.40.3-0.1-0.5-0.40.4-0.40.30.4-0.50.2-0.2-0.3-0.4-0.6-0.1-0.60.6
Fe content in liver0.30.31.20.3-0.2-0.40.6-0.90.30.0-0.6-0.10.2-0.80.80.2-0.50.9-0.90.4-0.2-0.4-1.10.3-0.3
K content in liver0.40.42.90.2-0.1-0.10.4-0.3-0.10.7-0.4-0.4-0.2-0.80.80.1-0.41.1-1.20.5-0.9-0.6-1.7-0.30.3
Mg content in liver0.20.20.7-0.90.50.5-0.40.4-0.60.90.30.4-0.50.1-0.1-0.30.20.1-0.10.7-0.1-0.1-0.40.0-0.0
Mn content in liver0.30.41.40.1-0.1-0.10.4-0.60.20.4-0.5-0.00.2-1.11.10.2-0.31.0-0.90.6-0.8-0.5-1.20.1-0.1
Na content in liver0.40.42.5-0.40.50.7-0.60.1-0.30.80.20.5-0.7-0.30.3-0.60.50.8-0.81.1-0.2-0.1-1.60.5-0.5
Rb content in liver0.80.92.5-1.31.41.3-1.10.4-0.91.50.51.4-0.8-0.10.1-1.21.0-0.10.11.60.30.2-0.31.0-1.0
Se content in liver1.31.63.2-0.61.41.6-1.41.2-1.51.71.31.4-1.60.3-0.3-1.51.6-0.10.01.80.41.2-0.81.7-1.7
Sr content in liver0.30.30.90.5-0.8-0.50.4-0.00.4-0.8-0.1-0.70.40.2-0.20.6-0.5-0.50.5-0.8-0.1-0.00.9-0.30.3
Zn content in liver0.60.72.3-1.11.11.0-0.80.4-1.01.50.51.0-1.00.2-0.2-1.00.7-0.20.21.50.30.2-0.30.7-0.7
Bone: minimum diameter11.922.927.55.1-4.9-4.85.1-5.25.1-3.9-5.2-5.14.7-5.05.04.9-5.04.8-4.8-3.7-4.9-4.6-4.0-4.54.5
Time in familiar zone, hab. session 11.31.42.41.0-1.1-1.11.2-1.31.2-0.7-1.4-1.31.2-1.11.11.3-1.50.8-0.9-1.0-1.3-1.5-0.6-1.51.5
Time in novel zone, hab. session 11.21.42.4-0.80.91.0-1.31.1-0.90.21.21.3-0.61.2-1.1-1.11.4-1.21.30.51.51.61.51.5-1.5
Total zone transitions, hab. session 10.40.62.11.5-1.2-1.20.9-0.30.9-1.4-0.2-0.80.7-0.10.11.0-0.70.2-0.2-1.20.00.60.10.3-0.3
Total locomotion distance, hab. session 11.11.64.91.9-1.9-2.01.7-0.81.4-2.2-0.7-1.41.3-0.60.61.6-1.20.6-0.6-1.8-0.30.4-0.20.2-0.2
Locomotion velocity, hab. session 11.01.53.71.8-1.8-1.91.8-0.81.3-1.9-0.8-1.41.1-0.60.61.5-1.30.8-0.8-1.6-0.50.1-0.5-0.00.0
Time in familiar zone, hab. session 21.11.32.50.9-1.1-0.80.9-1.30.9-0.7-1.3-1.20.9-0.90.90.9-1.21.3-1.3-0.8-0.8-1.4-1.3-1.61.6
Time in novel zone, hab. session 20.50.61.5-0.70.80.5-0.60.9-0.50.50.90.8-0.50.4-0.4-0.50.8-0.80.90.60.30.90.91.2-1.2
Total zone transitions, hab. session 20.30.41.10.6-0.6-0.50.20.30.1-1.00.4-0.30.20.8-0.80.20.1-0.60.6-0.90.91.00.90.7-0.7
Total locomotion distance, hab. session 20.71.03.91.6-1.4-1.41.2-0.11.0-2.0-0.2-1.10.90.2-0.11.2-0.70.1-0.2-1.90.00.60.2-0.10.1
Locomotion velocity, hab. session 20.50.72.81.5-1.2-1.20.90.00.7-1.7-0.0-1.00.60.3-0.31.0-0.50.0-0.1-1.60.10.60.2-0.00.0
Novel to familiar place preference ratio1.62.13.71.3-1.5-1.81.9-1.41.8-1.5-1.4-1.31.7-1.61.61.8-1.71.2-1.1-1.2-1.4-1.0-0.6-0.90.9
Novelty place preference1.01.32.51.0-1.3-1.51.6-1.11.5-1.3-1.1-1.01.3-1.21.21.4-1.30.8-0.8-0.9-1.0-0.7-0.3-0.60.6
Time in novel zone, NPP test0.91.12.30.9-1.2-1.41.5-1.11.5-1.2-1.0-0.91.2-1.21.21.3-1.30.8-0.7-0.8-0.9-0.6-0.2-0.40.4
Total zone transitions, NPP test0.20.31.21.0-0.5-0.30.10.30.0-0.80.4-0.10.10.2-0.20.10.3-0.00.0-0.60.41.1-0.11.0-1.0
Total locomotion distance, NPP test0.71.03.01.6-1.5-1.41.2-0.71.0-1.7-0.7-1.21.0-0.40.41.1-0.90.7-0.7-1.6-0.30.0-0.6-0.20.2
Locomotion velocity, NPP test0.40.62.31.5-1.1-1.10.9-0.20.6-1.4-0.2-0.90.7-0.10.20.8-0.40.5-0.5-1.3-0.20.5-0.50.1-0.1
Intraocular pressure0.20.32.50.40.0-0.0-0.10.0-0.3-0.20.20.30.4-0.10.1-0.40.60.3-0.4-0.00.20.8-0.51.6-1.6
Delta distance traveled before/after self-admin0.20.20.90.5-0.4-0.50.4-0.50.9-1.0-0.3-0.01.0-0.30.30.2-0.10.1-0.1-0.70.30.30.20.4-0.4
Delta ambulatory time before/after self-admin0.40.82.70.8-0.8-0.90.9-1.11.6-1.2-1.0-0.51.7-1.01.00.8-0.60.5-0.5-1.0-0.5-0.40.1-0.30.3
Parametrial fat weight0.40.93.1-0.4-0.4-0.60.8-0.70.6-0.1-0.9-0.90.5-0.80.81.0-1.30.4-0.4-0.2-1.3-1.7-0.2-1.81.8
Pavlov. Cond. lever latency0.20.31.2-1.10.80.6-0.40.3-0.01.10.10.3-0.4-0.00.0-0.2-0.0-0.30.30.8-0.6-0.70.4-0.20.2
Pavlov. Cond. magazine entry latency1.62.13.21.5-1.6-1.61.7-1.61.5-1.4-1.4-1.31.4-1.71.71.4-1.41.8-1.8-1.0-1.2-0.8-1.7-0.40.4
Pavlov. Cond. change in total contacts0.91.02.01.3-1.3-1.21.2-1.11.0-1.4-0.9-0.91.1-0.90.90.9-0.81.0-1.0-1.1-0.2-0.3-0.9-0.50.5
Pavlov. Cond. index score0.91.12.01.4-1.4-1.21.2-1.20.9-1.3-1.0-0.91.0-1.11.11.0-0.91.2-1.2-0.9-0.5-0.3-1.3-0.30.3
Pavlov. Cond. latency score0.50.61.81.4-1.2-1.00.9-0.80.6-1.1-0.6-0.70.8-0.80.80.7-0.50.9-0.9-0.8-0.20.0-1.0-0.10.1
Pavlov. Cond. lever contacts0.20.31.11.0-0.9-0.70.5-0.30.1-1.0-0.2-0.50.30.2-0.20.4-0.30.1-0.1-0.90.60.4-0.1-0.20.2
Pavlov. Cond. magazine entry number1.11.42.9-0.91.11.2-1.31.4-1.10.91.20.8-1.11.6-1.7-1.11.1-1.61.60.41.10.81.70.2-0.2
Pavlov. Cond. intertrial magazine entries2.42.84.82.2-1.7-1.92.0-1.51.8-1.5-1.4-1.61.6-2.02.01.8-1.62.0-2.0-1.3-1.9-0.9-1.9-0.70.7
Pavlov. Cond. lever-magazine prob. diff.0.91.12.21.4-1.3-1.21.2-1.20.9-1.2-1.0-0.91.0-1.21.21.0-0.91.4-1.4-0.9-0.6-0.3-1.5-0.20.2
Pavlov. Cond. response bias1.51.83.21.3-1.5-1.51.5-1.61.3-1.3-1.4-1.11.3-1.61.61.3-1.31.8-1.8-0.9-1.0-0.8-1.8-0.40.4
Pavlov. Cond. lever latency0.50.71.6-0.70.60.7-0.71.2-0.80.61.00.4-0.91.3-1.3-0.50.6-1.11.10.20.60.61.1-0.10.1
Pavlov. Cond. magazine entry latency2.13.05.1-2.22.12.2-2.11.3-1.92.11.42.0-1.81.1-1.1-2.02.0-1.21.22.31.31.00.61.9-1.9
Pavlov. Cond. change in total contacts0.20.41.20.5-0.2-0.10.2-1.10.40.1-0.9-0.20.3-1.01.00.0-0.30.8-0.80.3-0.5-0.9-1.1-0.20.2
Pavlov. Cond. index score0.10.20.6-0.40.40.3-0.3-0.6-0.10.4-0.40.50.1-0.60.6-0.40.30.4-0.40.80.1-0.3-0.70.7-0.7
Pavlov. Cond. latency score0.20.41.4-0.60.70.7-0.6-0.4-0.40.8-0.20.8-0.2-0.50.5-0.80.60.3-0.31.20.2-0.1-0.71.0-1.0
Pavlov. Cond. lever contacts0.30.51.00.7-0.6-0.70.6-1.00.7-0.7-0.8-0.20.8-1.01.00.5-0.50.9-0.9-0.2-0.4-0.3-0.90.3-0.3
Pavlov. Cond. magazine entry number3.24.26.72.4-2.5-2.52.4-1.62.3-2.4-1.7-2.52.2-1.41.42.5-2.31.4-1.4-2.6-1.7-1.3-0.7-2.22.2
Pavlov. Cond. intertrial magazine entries5.311.618.34.2-4.1-3.93.9-3.03.5-3.7-3.2-4.33.8-2.42.43.9-3.72.5-2.5-4.1-3.0-2.6-1.3-3.53.5
Pavlov. Cond. lever-magazine prob. diff.0.20.31.0-0.50.50.5-0.4-0.5-0.20.6-0.30.6-0.1-0.50.5-0.60.40.4-0.41.00.1-0.3-0.70.8-0.8
Pavlov. Cond. response bias0.10.20.60.3-0.1-0.30.3-0.70.3-0.1-0.50.00.4-0.70.70.1-0.20.6-0.60.2-0.2-0.2-0.80.4-0.4
Time in closed arm before self-admin0.10.20.80.4-0.3-0.2-0.1-0.40.5-0.9-0.20.30.9-0.30.3-0.20.40.2-0.2-0.40.40.50.20.8-0.8
Time in closed arm after self-admin0.10.10.4-0.40.00.2-0.3-0.10.3-0.2-0.00.1-0.00.4-0.4-0.20.1-0.40.4-0.10.5-0.00.70.2-0.2
Time in open arm before self-admin1.41.72.5-1.61.51.5-1.41.3-1.51.31.21.3-1.21.3-1.3-1.51.2-1.51.61.11.20.91.31.0-1.0
Time in open arm after self-admin0.40.41.7-0.50.80.6-0.40.6-1.21.30.60.4-1.10.3-0.3-0.60.5-0.30.31.00.00.2-0.30.2-0.2
Bone: periosteal estimation9.021.328.94.7-4.8-4.85.0-5.45.0-4.0-5.2-4.74.6-5.05.04.6-5.04.6-4.6-3.6-4.5-4.4-3.7-3.93.9
Bone: periosteal perimeter4.07.911.52.9-2.6-2.52.7-3.22.7-1.6-3.1-2.72.3-3.43.42.5-2.73.4-3.4-1.4-3.1-2.8-3.3-2.62.6
Bone: post-yield work1.73.03.61.8-1.8-1.71.8-1.91.8-1.4-1.9-1.81.6-1.81.81.8-1.81.9-1.9-1.2-1.8-1.7-1.7-1.41.4
Progressive ratio test 1 active lever presses1.62.96.82.3-2.3-2.11.9-1.62.4-2.6-1.4-1.62.2-1.61.61.8-1.51.5-1.5-2.1-1.0-0.2-0.8-0.10.1
Progressive ratio test 1 breakpoint1.93.37.82.5-2.5-2.32.1-1.72.5-2.8-1.6-1.72.3-1.61.72.0-1.61.5-1.5-2.3-1.1-0.3-0.8-0.30.3
Progressive ratio test 1 inactive lever presses1.74.69.12.8-2.9-2.72.5-2.12.5-3.0-2.0-2.32.5-1.81.82.4-2.11.9-1.9-2.5-1.3-0.8-1.3-0.80.8
Progressive ratio test 2 active lever presses1.92.73.91.9-1.8-1.71.8-1.71.8-1.4-1.7-1.71.3-2.02.01.6-1.51.9-1.9-1.1-1.8-1.1-1.9-0.60.6
Progressive ratio test 2 breakpoint2.33.04.31.9-1.9-1.81.9-1.91.9-1.5-1.8-1.81.5-2.12.11.6-1.62.0-2.0-1.1-1.9-1.2-2.0-0.80.8
Progressive ratio test 2 inactive lever presses0.82.65.22.3-2.1-2.12.0-1.11.9-2.0-1.1-1.81.4-1.41.41.9-1.51.5-1.5-1.7-1.5-0.4-1.4-0.60.6
Incentive Sensitization - Responses0.20.72.60.9-0.8-0.60.9-0.70.3-0.0-0.7-1.1-0.2-0.80.70.6-0.71.2-1.2-0.0-1.1-0.8-1.6-0.60.6
Incentive Sensitization - Breakpoint0.30.72.80.8-0.8-0.60.8-0.70.30.0-0.8-1.1-0.2-0.80.80.5-0.81.2-1.20.0-1.2-0.9-1.7-0.70.7
Sum of active levers in priming session hrs 5-61.00.92.1-1.01.01.0-1.10.8-0.60.71.01.4-0.40.8-0.8-1.11.0-0.50.50.91.21.20.71.4-1.4
Progressive ratio0.20.52.2-0.40.60.5-0.10.1-0.61.5-0.0-0.2-1.1-0.40.4-0.40.10.6-0.61.2-1.0-1.0-1.3-0.60.6
Food seeking constrained by brief footshock1.92.34.61.1-1.6-1.41.3-2.21.8-1.2-2.1-1.82.1-1.21.21.3-1.61.0-1.0-1.2-1.1-2.1-0.1-1.91.9
Seeking ratio, punishment vs. effort0.81.74.91.5-1.8-1.61.2-1.51.7-2.2-1.3-1.21.9-0.60.61.5-1.40.7-0.7-1.9-0.1-0.40.2-0.70.7
Retroperitoneal fat weight0.62.610.31.7-2.3-2.31.8-0.11.3-3.2-0.3-2.01.40.5-0.52.3-1.9-0.20.2-3.0-0.10.31.2-0.90.9
Reaction time number correct0.20.71.7-1.01.20.7-0.70.6-0.71.10.61.1-1.0-0.00.1-0.70.7-0.50.51.30.00.50.01.1-1.1
Reaction time mean minus median0.00.20.6-0.80.40.3-0.30.5-0.40.50.40.4-0.00.6-0.6-0.30.2-0.60.60.20.30.10.7-0.20.2
Reaction time mean minus median AUC0.00.20.7-0.80.70.4-0.20.2-0.20.90.20.80.2-0.20.2-0.30.30.2-0.20.8-0.10.1-0.20.5-0.5
Reaction time num false alarms1.42.34.31.9-1.5-1.31.5-1.91.6-1.1-1.7-1.41.1-2.12.11.2-1.21.9-1.9-0.7-1.6-1.2-1.8-0.60.6
Reaction time num false alarms AUC1.33.15.41.9-1.7-1.61.7-2.22.1-1.3-2.0-1.61.6-2.32.31.5-1.52.1-2.1-1.0-1.8-1.5-1.9-0.90.9
Reaction time trials correct on left0.20.71.7-1.01.20.7-0.70.6-0.71.10.61.1-1.0-0.00.1-0.70.7-0.50.51.30.00.50.01.1-1.1
Reaction time trials on left0.20.61.6-0.91.10.7-0.60.5-0.71.00.61.0-1.0-0.10.2-0.70.6-0.40.51.2-0.10.4-0.01.1-1.1
Reaction time mean0.10.31.3-1.10.80.5-0.3-0.0-0.21.00.00.7-0.2-0.20.2-0.50.10.4-0.41.1-0.1-0.4-0.60.3-0.3
Reaction time mean AUC0.20.41.9-1.41.00.7-0.50.2-0.31.00.21.0-0.20.1-0.1-0.70.30.1-0.11.10.3-0.1-0.20.5-0.5
Median of all reaction times0.20.31.3-1.10.80.5-0.2-0.20.00.9-0.10.7-0.2-0.40.4-0.50.10.6-0.61.1-0.1-0.3-0.80.5-0.5
Reaction time omissions0.61.02.30.7-1.0-1.11.2-1.01.5-0.8-1.1-1.11.3-1.01.01.2-1.10.5-0.5-0.9-1.3-1.10.2-1.11.1
Reaction time false alarm rate1.92.64.11.9-1.8-1.51.5-2.01.8-1.4-1.9-1.71.6-1.71.71.4-1.41.8-1.8-1.3-1.3-1.4-1.5-1.21.2
Reaction time premature initiation rate0.71.13.71.9-1.4-1.31.3-0.51.2-1.3-0.5-1.20.9-0.60.61.1-0.90.8-0.8-1.5-0.6-0.1-0.5-0.90.9
Reaction time premature initiations0.10.31.51.2-0.7-0.80.8-0.20.7-0.7-0.2-0.50.3-0.50.60.6-0.40.4-0.4-0.7-0.60.1-0.3-0.30.3
Std. dev. reaction times0.10.20.7-0.80.40.20.0-0.3-0.10.8-0.30.20.2-0.10.1-0.1-0.30.2-0.20.4-0.3-0.9-0.1-0.70.7
Reaction time trials completed0.20.61.6-0.91.10.7-0.60.5-0.71.00.61.0-1.0-0.10.2-0.70.6-0.40.51.2-0.10.4-0.01.1-1.1
Reaction time trials AUC0.10.41.2-0.91.00.6-0.50.5-0.60.90.50.9-0.9-0.10.2-0.60.5-0.40.41.1-0.10.4-0.00.9-0.9
Run reversals in cocaine runway, females1.61.85.9-0.80.20.6-1.02.0-1.1-0.51.70.4-1.22.4-2.4-0.10.7-1.81.8-0.51.71.61.8-0.10.1
Run reversals in cocaine runway, males0.10.10.8-0.50.40.1-0.10.2-0.30.90.10.1-0.7-0.20.2-0.20.00.1-0.00.7-0.5-0.3-0.5-0.10.1
Latency to leave start box in cocaine runway0.60.82.3-0.60.40.6-0.70.9-0.90.20.90.7-0.91.3-1.3-0.80.7-0.70.70.11.51.30.51.3-1.3
Latency to leave start box in cocaine runway, F1.62.04.3-0.91.21.3-1.41.3-1.61.11.41.4-1.61.4-1.4-1.71.6-0.70.71.01.91.80.02.1-2.1
Latency to leave start box in cocaine runway, M0.30.31.1-0.2-0.6-0.20.1-0.00.2-0.9-0.1-0.30.50.6-0.60.5-0.6-0.60.5-0.90.50.01.0-0.30.3
Std. dev. time between licks in bursts0.20.41.80.1-0.00.1-0.21.0-0.3-0.40.8-0.0-0.41.0-1.0-0.00.4-1.11.1-0.50.50.81.40.3-0.3
Total sessions with >9 infusions0.50.63.20.7-0.4-0.2-0.10.60.1-1.00.70.30.30.3-0.3-0.10.7-0.20.2-0.60.81.80.51.7-1.7
Short access day 1 total inactive lever presses0.91.84.32.1-2.0-1.81.7-0.71.1-1.9-0.7-1.70.9-0.70.71.5-1.21.5-1.5-1.7-0.80.1-1.6-0.30.3
Short access day 10 total inactive lever presses0.10.81.71.2-1.1-1.11.00.00.5-1.1-0.2-1.20.4-0.00.01.3-1.10.5-0.5-1.3-0.5-0.2-0.6-1.31.3
Short access day 1 total infusions0.40.94.41.1-0.6-0.60.40.60.2-1.10.80.10.00.00.00.10.50.7-0.7-0.40.41.9-0.82.1-2.1
Short access day 10 total infusions2.23.69.02.8-2.7-2.52.2-1.62.3-3.0-1.5-2.02.3-1.41.42.2-1.61.4-1.4-2.5-1.1-0.2-0.8-0.50.5
Short access total infusions0.91.33.61.9-1.7-1.51.4-0.81.2-1.9-0.6-1.01.1-0.90.91.1-0.71.2-1.2-1.3-0.50.4-1.00.6-0.6
Short access day 1 locomotion1.01.76.12.5-1.9-1.81.30.00.8-2.40.1-1.11.5-0.50.61.4-0.51.0-1.0-2.1-0.41.4-0.80.9-0.9
Short access day 10 total locomotion1.55.911.93.2-3.3-3.12.8-2.12.8-3.5-2.0-2.72.8-1.71.72.8-2.42.1-2.1-3.2-1.5-0.9-1.1-1.41.4
Short access total locomotion1.62.48.22.7-2.4-2.11.7-0.61.6-2.9-0.6-1.71.7-0.70.71.8-1.01.1-1.1-2.5-0.60.7-0.50.2-0.2
One hour access (0.3 mA shock)0.50.61.60.5-0.7-0.70.7-1.21.0-0.6-1.1-0.51.2-1.11.10.4-0.40.9-0.8-0.3-0.6-0.6-0.30.1-0.1
Compulsive drug intake0.50.72.1-1.41.31.2-1.1-0.3-0.41.2-0.11.20.3-0.40.4-1.20.9-0.10.11.40.2-0.40.10.8-0.8
One hour access (shock baseline)0.41.02.21.4-1.5-1.41.3-0.81.0-1.2-0.8-1.30.7-0.70.71.2-1.00.7-0.7-1.2-0.8-0.3-0.4-0.70.7
Social response proportion0.10.10.4-0.00.20.1-0.2-0.40.6-0.2-0.30.40.6-0.50.60.00.0-0.00.1-0.0-0.1-0.10.40.0-0.0
Social responses0.50.72.30.7-0.8-0.90.8-1.11.4-1.3-0.9-0.21.5-1.01.10.8-0.80.4-0.3-0.9-0.2-0.10.40.4-0.4
Social time0.30.51.7-1.30.91.1-1.1-0.0-0.11.00.00.8-0.50.1-0.1-0.80.5-0.50.51.10.2-0.40.40.3-0.3
Soleus weight0.00.10.40.20.20.2-0.20.1-0.40.20.20.4-0.5-0.30.3-0.40.50.4-0.40.40.10.5-0.70.4-0.4
Bone: stiffness1.22.13.81.9-1.5-1.51.6-1.61.4-1.1-1.5-1.51.4-1.81.81.5-1.51.5-1.5-1.0-1.7-1.1-1.4-0.80.8
Tibialis anterior weight0.31.14.70.9-1.2-1.10.50.60.6-2.00.5-0.70.61.1-1.11.0-0.4-0.90.9-2.20.81.01.5-0.40.4
Time to tail flick, vehicle, before self-admin0.81.03.0-0.90.80.9-0.5-0.80.31.7-0.80.3-0.1-1.01.0-0.6-0.11.2-1.31.4-1.1-1.7-1.7-0.70.7
Time to tail flick, vehicle, after self-admin0.20.51.60.20.40.3-0.1-0.5-0.10.7-0.50.10.1-1.21.20.1-0.10.9-0.90.6-1.3-0.9-1.2-0.60.6
Time to tail flick, test, before self-admin0.40.41.2-0.1-0.2-0.40.6-1.01.0-0.0-0.9-0.31.1-0.70.70.5-0.90.2-0.2-0.2-0.4-1.10.3-0.80.8
Time to tail flick, test, after self-admin0.40.51.50.2-0.4-0.50.5-1.10.7-0.3-0.9-0.21.2-1.11.10.5-0.60.8-0.8-0.4-0.6-0.7-0.3-0.20.2
Delta time to tail flick, vehicle, before/after SA1.01.02.01.2-1.0-1.11.1-0.90.7-1.1-1.0-1.21.4-0.90.91.3-1.00.4-0.3-1.2-1.1-0.90.3-1.21.2
Delta time to tail flick, test, before/after SA0.30.31.9-0.00.1-0.00.2-0.4-0.20.6-0.4-0.1-0.4-0.80.8-0.1-0.20.9-0.90.5-0.7-0.6-1.4-0.20.2
Tibia length0.10.41.60.30.40.2-0.1-0.3-0.10.4-0.10.5-0.1-1.01.0-0.50.60.9-0.90.6-0.50.2-1.30.8-0.8
Ambulatory time before self-admin0.41.33.4-1.31.31.4-1.30.8-1.71.60.81.2-1.30.6-0.6-1.41.2-0.10.11.80.70.5-0.41.2-1.2
Ambulatory time after self-admin0.10.10.3-0.00.10.00.1-0.40.20.0-0.20.20.3-0.40.4-0.30.10.5-0.50.30.00.0-0.50.3-0.3
Bone: tissue strength0.91.02.4-0.71.11.0-0.90.9-1.11.11.01.1-1.30.4-0.4-1.11.0-0.40.41.30.61.1-0.11.6-1.6
Total heroin consumption0.30.41.5-0.40.30.4-0.3-0.6-0.00.7-0.40.5-0.0-0.70.7-0.60.31.0-1.00.9-0.1-0.2-1.20.7-0.7
Bone: trabecular number0.71.33.01.4-0.8-0.71.0-1.10.7-0.1-1.2-1.20.7-1.51.50.7-0.81.5-1.6-0.5-1.7-1.3-1.7-0.90.9
Bone: trabecular spacing0.30.51.3-1.00.50.5-0.60.5-0.50.20.60.6-0.60.9-0.9-0.50.4-1.01.00.41.10.61.10.4-0.4
Bone: trabecular thickness0.81.22.51.6-1.0-0.91.0-0.90.9-0.6-1.0-1.21.1-1.31.31.1-0.81.0-1.0-0.9-1.6-1.0-0.8-1.11.1
Bone: trabecular tissue density0.40.71.60.00.90.8-0.81.2-0.90.81.20.9-0.70.5-0.4-0.71.1-0.90.90.70.31.30.70.9-0.9
Water consumed over 24 hours0.20.41.80.8-0.8-0.60.20.30.4-1.30.2-0.40.60.5-0.50.5-0.1-0.50.5-1.10.50.80.90.2-0.2
Number of responses in last shaping day0.10.10.50.3-0.2-0.30.20.60.0-0.60.6-0.1-0.40.3-0.30.4-0.1-0.20.2-0.20.10.7-0.20.5-0.5