Hub : Genes

Helz

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Helz 0.21 0.11 6.9e-04 0.14 0.11 0.15 0.12 2.5e-04 1.6e-03 1.7e-04 7.4e-04
2 Brain gene expression Helz 0.15 0.06 5.6e-17 0.17 0.18 0.18 0.19 2.6e-15 3.9e-16 1.1e-16 4.6e-17
3 BLA alternative polyA XM_039085638.1 0.09 0.07 3.2e-03 0.02 0.03 0.01 0.02 2.9e-02 6.7e-03 1.0e-01 2.8e-02
4 NAcc mRNA stability Helz 0.02 0.01 1.9e-03 0.02 0.01 0 0.01 8.7e-04 2.2e-02 2.3e-01 2.6e-02
5 PL gene expression Helz 0.37 0.11 0.0e+00 0.41 0.41 0.41 0.42 6.6e-49 6.1e-49 7.6e-49 8.9e-51
6 BLA gene expression Helz 0.43 0.13 0.0e+00 0.41 0.38 0.42 0.42 8.5e-24 2.6e-21 1.9e-24 2.5e-24
7 PL mRNA stability Helz 0.06 0.03 2.1e-07 0.07 0.07 0.07 0.08 1.4e-08 5.9e-08 1.4e-08 8.0e-09
8 pVTA gene expression Helz 0.13 0.06 1.2e-04 0.09 0.08 0.09 0.1 1.0e-04 2.1e-04 1.3e-04 6.6e-05
9 Adipose isoform ratio XM_006247565.4 0.02 0.01 8.1e-03 0 0.01 -0 0 1.8e-01 3.6e-02 4.1e-01 3.1e-01
10 OFC gene expression Helz 0.27 0.11 1.2e-05 0.12 0.18 0.14 0.14 1.1e-03 5.8e-05 3.6e-04 3.2e-04
11 BLA isoform ratio XM_006247562.4 0.07 0.05 3.2e-03 0.02 0.03 0.02 0.03 1.9e-02 1.6e-02 3.7e-02 1.6e-02
12 Adipose alternative polyA XM_039085638.1 0.11 0.05 6.3e-10 0.08 0.08 0.08 0.08 3.7e-09 4.2e-09 3.5e-09 2.3e-09
13 Adipose alternative polyA NM_001105848.2 0.11 0.05 7.0e-10 0.08 0.08 0.08 0.08 4.0e-09 4.5e-09 3.5e-09 3.5e-09
14 Adipose alternative polyA XM_039085638.1 0.11 0.05 4.2e-10 0.08 0.08 0.08 0.08 6.4e-09 2.2e-09 1.3e-09 2.1e-09
15 Adipose alternative polyA NM_001105848.2 0.11 0.05 2.0e-10 0.08 0.09 0.09 0.09 2.7e-09 1.1e-09 4.3e-10 1.1e-09
16 Adipose isoform ratio XM_039085644.1 0.03 0.02 2.5e-04 0.03 0.03 0.03 0.03 3.9e-04 1.9e-04 6.9e-04 6.5e-04
17 BLA mRNA stability Helz 0.13 0.07 1.1e-05 0.07 0.09 0.04 0.09 1.4e-04 1.8e-05 1.9e-03 1.5e-05
18 NAcc gene expression Helz 0.08 0.03 2.2e-13 0.11 0.12 0.11 0.11 6.2e-13 1.5e-13 2.3e-12 4.4e-13
19 Adipose isoform ratio NM_001105848.2 0.12 0.06 5.8e-12 0.06 0.1 0.1 0.09 9.3e-07 4.5e-11 2.4e-11 1.9e-10
20 NAcc alternative polyA XM_039085638.1 0.05 0.03 6.0e-03 0.03 0.01 0.03 0.03 1.1e-04 6.9e-03 1.6e-04 2.2e-04
21 Brain alternative polyA NM_001105848.2 0.03 0.02 2.4e-03 0.04 0.02 0.02 0.02 2.7e-04 3.6e-03 3.8e-03 3.6e-03
22 Brain alternative polyA XM_039085638.1 0.03 0.02 7.0e-03 0.03 0.02 0.01 0.02 6.2e-04 9.7e-03 6.3e-02 5.0e-03
23 Brain alternative polyA NM_001105848.2 0.04 0.02 2.4e-03 0.04 0.03 0.03 0.03 2.0e-04 1.9e-03 1.7e-03 1.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Bone: apparent density0.71.22.61.6-1.0-1.00.9-0.90.9-0.6-0.7-1.1-1.1-1.2-1.11.11.3-1.4-1.3-0.8-1.3-1.60.5-1.21.2-1.2
Area under the delay curve0.30.31.00.40.50.2-0.20.3-0.30.80.70.30.2-0.4-0.60.70.8-0.90.00.7-0.2-1.00.60.3-0.30.3
BMI with tail1.03.215.40.9-1.81.70.6-0.81.4-2.4-2.31.2-0.91.12.1-2.2-1.41.61.9-2.8-1.01.8-3.91.3-1.31.3
BMI without tail1.83.712.42.1-3.0-0.21.9-2.02.6-3.5-3.4-0.7-2.4-0.90.2-0.30.8-0.60.3-3.5-2.4-0.3-2.40.4-0.40.4
Body weight1.56.317.33.5-3.9-1.33.0-3.03.5-4.1-4.2-1.7-3.1-1.7-0.90.81.3-1.2-1.1-4.1-3.0-0.8-1.5-0.90.9-0.9
Weight adjusted by age1.61.84.4-0.91.31.5-1.01.6-1.62.11.81.71.71.50.9-0.8-1.31.21.31.61.31.2-1.10.9-0.90.9
Bone surface4.98.612.53.5-2.6-3.42.9-2.92.7-2.1-2.2-3.2-2.7-3.1-3.33.33.2-3.2-3.5-1.9-2.5-3.22.3-3.03.0-3.0
Bone volume4.06.811.43.4-2.3-2.82.5-2.62.4-1.7-2.0-2.7-2.5-2.9-2.92.92.9-3.0-3.0-1.7-2.5-3.02.0-2.52.5-2.5
Breakpoint value in progressive ratio session0.40.41.0-0.40.20.5-0.40.3-0.40.00.40.80.80.80.3-0.4-0.50.50.50.31.00.9-0.31.0-1.01.0
Number of licking bursts0.00.00.1-0.30.0-0.2-0.0-0.0-0.1-0.00.1-0.10.1-0.1-0.30.20.2-0.2-0.10.10.2-0.10.30.1-0.10.1
Context. condit. distance diff. score0.00.00.10.10.10.4-0.10.0-0.00.20.00.30.20.2-0.00.0-0.10.10.1-0.10.10.2-0.0-0.10.1-0.1
Locomotion velocity, session 10.20.20.50.5-0.6-0.60.3-0.40.4-0.5-0.4-0.4-0.4-0.5-0.50.50.7-0.7-0.4-0.3-0.3-0.60.4-0.10.1-0.1
Locomotion distance, session 10.10.20.90.9-0.5-0.30.4-0.30.5-0.3-0.4-0.0-0.2-0.3-0.50.50.6-0.6-0.0-0.2-0.2-0.40.00.5-0.50.5
Locomotion velocity, session 20.20.21.20.1-0.3-1.10.3-0.40.3-0.6-0.5-0.7-0.1-0.1-0.70.70.3-0.3-0.5-0.10.50.10.10.6-0.60.6
Locomotion distance, session 20.20.32.0-0.10.1-0.3-0.30.2-0.1-0.3-0.10.10.30.2-0.10.10.00.00.40.20.60.4-0.51.4-1.41.4
Locomotion velocity, session 31.72.04.6-0.41.21.2-1.61.6-1.41.31.31.61.51.30.9-0.9-0.90.91.61.31.51.0-1.12.1-2.12.1
Locomotion distance, session 30.30.31.10.40.6-0.2-0.60.6-0.60.90.80.20.6-0.1-0.50.50.4-0.4-0.01.00.6-0.40.80.6-0.60.6
Stereotopy head waving bouts, day 31.01.22.6-1.01.11.6-1.11.2-1.11.31.11.61.31.21.0-1.0-0.90.91.31.11.00.9-0.50.9-0.90.9
Stereotopy head waving duration, day 31.01.22.2-1.11.31.3-1.01.3-1.21.51.31.41.30.90.7-0.6-0.60.61.21.41.00.5-0.41.1-1.11.1
Locomotion velocity, session 70.40.41.3-0.20.00.8-0.30.4-0.30.10.10.70.51.00.9-1.0-1.01.00.5-0.20.51.1-0.60.1-0.10.1
Locomotion distance, session 70.10.10.30.4-0.3-0.30.3-0.40.4-0.3-0.3-0.3-0.3-0.3-0.30.30.2-0.2-0.3-0.2-0.3-0.10.5-0.10.1-0.1
Stereotopy head waving bouts, day 72.22.53.6-1.11.51.4-1.71.9-1.81.91.61.71.81.71.3-1.2-1.51.41.61.51.81.4-1.21.6-1.61.6
Stereotopy head waving duration, day 74.04.97.8-2.22.61.7-2.52.7-2.72.82.72.22.72.21.5-1.4-1.81.82.02.52.81.7-0.92.1-2.12.1
Locomotion velocity, session 80.20.31.01.0-0.4-0.60.5-0.40.4-0.2-0.3-0.5-0.3-0.2-0.40.40.3-0.3-0.8-0.4-0.1-0.20.5-0.90.9-0.9
Locomotion distance, session 80.10.10.30.5-0.2-0.40.2-0.30.3-0.3-0.3-0.2-0.1-0.1-0.50.50.3-0.3-0.2-0.30.10.0-0.00.1-0.10.1
Degree of sensitization distance0.50.51.10.4-0.9-0.30.9-1.01.0-1.0-1.0-0.6-0.9-0.4-0.10.10.2-0.1-0.6-1.1-1.0-0.10.1-0.90.9-0.9
Degree of sensitization stereotypy2.62.94.8-1.21.41.2-1.81.9-1.81.71.61.61.91.81.3-1.2-1.61.61.81.42.21.7-1.62.0-2.02.0
Conditioned locomotion0.10.10.30.3-0.50.00.3-0.40.5-0.4-0.5-0.1-0.3-0.00.3-0.3-0.10.1-0.1-0.5-0.40.2-0.4-0.30.3-0.3
Cocaine response after cond. corrected0.40.41.5-1.21.00.4-0.70.7-0.81.01.00.40.70.40.3-0.3-0.50.50.41.10.60.20.40.5-0.50.5
Cocaine response after cond. not corrected0.91.02.6-1.51.60.2-1.11.1-1.31.51.50.51.30.80.3-0.2-0.60.50.41.61.40.40.60.6-0.60.6
Cocaine response before conditioning0.30.31.4-0.00.8-0.3-0.40.6-0.60.80.70.20.90.3-0.40.40.4-0.40.20.91.2-0.20.40.4-0.40.4
Saline control response0.50.73.40.4-1.30.20.5-0.70.9-1.6-1.4-0.1-0.90.10.5-0.5-0.30.40.4-1.7-0.70.5-1.80.2-0.20.2
Bone: connectivity density1.11.72.91.7-1.3-1.41.2-1.11.0-0.9-0.8-1.4-1.3-1.4-1.41.41.5-1.5-1.6-0.9-1.3-1.60.7-1.31.3-1.3
Bone: cortical apparent density2.43.18.1-1.31.02.8-1.61.6-1.31.11.12.51.31.82.1-2.1-1.91.92.50.60.81.6-2.21.9-1.91.9
Bone: cortical area2.33.512.43.5-2.6-1.52.0-2.02.3-2.3-2.5-1.4-2.1-1.7-1.31.31.6-1.7-1.1-2.4-2.1-1.6-0.6-1.11.1-1.1
Bone: cortical porosity2.83.06.61.6-1.7-2.62.0-1.91.8-1.8-1.8-2.3-1.6-1.6-1.91.91.6-1.6-2.0-1.4-1.0-1.21.1-1.51.5-1.5
Bone: cortical porosity2.12.34.91.6-1.4-2.21.7-1.61.5-1.4-1.5-1.9-1.4-1.6-1.91.91.7-1.7-1.5-1.0-0.9-1.40.9-0.90.9-0.9
Bone: cortical thickness3.04.918.80.20.43.1-1.91.7-1.10.30.33.01.32.32.7-2.6-2.02.03.5-0.31.01.9-4.32.7-2.72.7
Bone: cortical thickness1.51.77.30.4-0.01.6-0.80.7-0.4-0.2-0.21.40.51.31.6-1.6-1.31.31.9-0.60.51.6-2.71.7-1.71.7
Bone: cortical tissue density2.33.17.9-1.41.02.8-1.61.6-1.31.01.12.41.31.82.1-2.1-1.91.92.40.60.81.7-2.11.9-1.91.9
Condit. Reinf. active minus inactive responses2.83.26.41.4-1.2-2.41.9-1.91.7-1.3-1.4-2.0-1.4-2.1-2.52.52.3-2.3-1.8-0.7-1.0-2.02.0-1.01.0-1.0
Condit. Reinf. active-inactive response ratio1.01.13.70.4-0.3-1.40.9-1.00.7-0.5-0.4-1.2-0.6-1.3-1.61.61.4-1.5-1.2-0.0-0.4-1.31.9-0.70.7-0.7
Condit. Reinf. active responses3.54.27.22.3-1.7-2.52.4-2.32.1-1.6-1.9-2.2-1.7-2.2-2.72.72.5-2.5-2.0-1.2-1.4-2.21.7-1.61.6-1.6
Condit. Reinf. inactive responses1.61.94.92.2-1.6-1.31.7-1.51.7-1.1-1.6-1.1-1.2-1.2-1.51.51.3-1.3-1.2-1.1-1.2-1.30.4-1.31.3-1.3
Incentive salience index mean1.72.14.01.4-1.3-1.81.7-1.71.5-1.2-1.5-1.6-1.1-1.5-2.02.01.7-1.7-1.4-0.9-0.8-1.41.2-1.01.0-1.0
Condit. Reinf. lever presses0.10.10.60.5-0.50.00.3-0.30.3-0.3-0.60.10.20.5-0.10.1-0.30.30.3-0.50.40.6-0.8-0.00.0-0.0
Condit. Reinf. active minus inactive responses4.55.611.82.5-1.7-3.42.2-2.32.1-1.7-1.8-2.8-2.0-2.9-3.33.33.1-3.1-2.5-0.9-1.5-2.92.1-1.11.1-1.1
Condit. Reinf. active-inactive response ratio2.02.15.70.7-0.7-2.41.2-1.41.1-0.9-1.0-2.0-1.2-1.8-2.12.11.8-1.8-1.7-0.4-0.7-1.91.6-0.80.8-0.8
Condit. Reinf. active responses5.77.913.83.5-2.5-3.72.9-2.82.8-2.2-2.5-3.2-2.6-3.2-3.53.53.5-3.4-2.8-1.7-2.1-3.12.0-1.71.7-1.7
Condit. Reinf. inactive responses3.13.811.63.4-2.4-1.92.4-2.12.3-2.0-2.2-1.7-1.9-1.9-1.91.92.1-2.1-1.5-1.9-1.8-1.50.5-1.01.0-1.0
Condit. Reinf. lever presses2.53.36.02.3-2.1-2.52.0-2.02.1-2.2-2.2-2.2-2.0-2.0-1.92.01.9-1.9-1.4-1.8-1.5-1.60.0-0.60.6-0.6
Condit. Reinf. lever reinforcers received5.07.112.63.3-2.4-3.52.8-2.72.6-2.1-2.4-3.1-2.5-3.1-3.23.23.2-3.2-2.7-1.7-2.1-2.91.8-1.61.6-1.6
Conditioned reinforcement - actives0.20.20.7-0.4-0.4-0.50.2-0.20.3-0.8-0.4-0.5-0.5-0.5-0.40.30.6-0.5-0.1-0.2-0.2-0.50.30.4-0.40.4
Conditioned reinforcement - inactives1.61.73.51.8-1.9-1.11.6-1.41.4-1.3-1.2-1.1-1.4-1.2-1.51.51.3-1.4-1.2-1.3-1.4-1.3-0.0-1.01.0-1.0
Conditioned locomotion2.53.06.51.7-2.0-1.41.7-2.02.0-2.6-1.9-1.7-2.1-1.8-1.31.31.8-1.7-1.3-2.0-2.0-1.70.8-1.51.5-1.5
Patch foraging indifference point 0 sec5.99.614.23.7-3.8-3.03.6-3.53.6-3.7-3.5-3.2-3.6-3.5-3.02.93.2-3.1-2.6-3.1-3.5-2.81.2-1.71.7-1.7
Patch foraging indifference point AUC0.81.03.21.8-1.4-0.70.8-0.70.9-0.8-0.8-0.7-0.9-0.7-0.80.71.2-1.2-0.8-1.2-1.0-1.2-0.4-0.90.9-0.9
Delay disc. indifference point, 0s delay0.80.82.7-0.91.20.7-0.91.2-1.31.51.60.91.00.60.4-0.3-0.40.30.71.40.80.1-0.30.8-0.80.8
Delay disc. indifference point, 16s delay0.20.20.80.40.30.2-0.20.1-0.10.50.20.2-0.2-0.5-0.30.30.7-0.70.20.2-0.4-0.90.10.5-0.50.5
Delay disc. indifference point, 2s delay1.31.54.11.0-0.4-0.81.1-0.90.8-0.3-0.3-0.8-0.7-1.5-1.81.81.9-2.0-1.2-0.1-1.1-2.01.7-0.90.9-0.9
Delay disc. indifference point, 24s delay1.21.14.02.0-1.3-0.41.1-1.01.2-1.0-1.1-0.6-1.4-1.3-0.80.81.3-1.3-0.5-1.1-1.6-1.20.0-0.30.3-0.3
Delay disc. indifference point, 4s delay0.80.82.5-0.81.50.4-1.21.2-1.31.51.60.71.10.50.00.1-0.1-0.00.61.61.1-0.20.50.6-0.60.6
Delay disc. indifference point, 8s delay0.50.51.8-0.20.91.1-0.80.9-0.81.31.11.10.80.30.2-0.1-0.10.00.71.00.3-0.1-0.00.8-0.80.8
Indifference point function ln k0.10.20.50.10.50.4-0.10.1-0.10.40.00.60.60.30.2-0.1-0.50.40.60.50.50.70.20.6-0.60.6
Indifference point function log k0.10.20.50.10.50.4-0.10.1-0.10.40.00.60.60.30.2-0.1-0.50.40.60.50.50.70.20.6-0.60.6
Patch foraging total patch changes 0 sec5.58.913.63.7-3.6-3.03.4-3.23.4-3.4-3.2-3.1-3.5-3.5-2.82.83.1-3.0-2.6-2.9-3.4-2.91.1-1.71.7-1.7
Patch foraging total patch changes 12 sec5.87.69.92.9-3.1-2.93.0-3.13.0-2.7-2.8-3.0-3.1-3.1-2.82.72.9-2.8-2.9-2.5-3.0-2.71.6-2.02.0-2.0
Patch foraging total patch changes 18 sec1.72.14.92.2-2.2-1.31.7-1.61.7-1.8-1.7-1.4-1.7-1.4-1.31.31.3-1.3-1.2-1.8-1.6-1.0-0.3-0.70.7-0.7
Patch foraging total patch changes 24 sec4.35.211.23.3-3.1-2.02.6-2.42.5-2.4-2.3-2.0-2.5-2.3-2.42.32.6-2.6-1.8-2.4-2.5-2.4-0.1-1.21.2-1.2
Patch foraging total patch changes 6 sec4.66.910.52.7-3.2-2.83.1-3.03.0-2.8-2.9-2.8-3.0-3.0-2.82.72.8-2.8-2.4-2.5-2.8-2.50.9-1.41.4-1.4
Patch foraging time to switch 0 sec0.50.84.2-2.10.90.7-0.80.8-0.80.60.60.50.60.70.9-0.9-1.11.10.60.90.71.10.00.9-0.90.9
Patch foraging water rate 0 sec2.33.68.72.9-2.4-1.52.2-2.22.3-2.3-2.2-1.7-2.2-1.8-1.31.31.6-1.7-1.5-2.4-2.2-1.40.1-1.61.6-1.6
Patch foraging water rate 12 sec0.10.21.3-0.0-0.00.5-0.20.2-0.1-0.20.00.50.20.30.3-0.3-0.20.20.9-0.20.20.3-1.10.8-0.80.8
Patch foraging water rate 18 sec0.20.20.60.5-0.6-0.00.7-0.80.8-0.7-0.80.0-0.3-0.3-0.40.50.3-0.40.1-0.6-0.4-0.1-0.20.3-0.30.3
Patch foraging water rate 24 sec0.10.10.4-0.30.60.30.1-0.3-0.00.50.20.50.60.1-0.40.40.1-0.10.30.60.50.20.40.5-0.50.5
Patch foraging water rate 6 sec0.20.21.30.2-0.20.80.00.00.1-0.0-0.10.80.30.50.4-0.4-0.50.40.7-0.40.10.6-1.10.6-0.60.6
Seeking ratio, delayed vs. immediate footshock0.10.10.90.5-0.30.40.2-0.30.3-0.3-0.40.3-0.20.10.3-0.3-0.10.10.3-0.5-0.40.2-0.90.0-0.00.0
Distance traveled before self-admin1.41.55.2-1.41.90.2-1.61.6-1.71.91.90.71.50.5-0.10.2-0.20.10.52.31.6-0.20.90.9-0.90.9
Distance traveled after self-admin0.70.82.2-0.71.1-0.1-1.21.3-1.31.11.30.41.10.4-0.20.2-0.30.30.31.51.50.30.41.0-1.01.0
Extensor digitorum longus weight1.35.114.6-1.60.83.5-1.71.6-1.30.80.82.71.53.13.8-3.8-3.23.12.5-0.30.82.7-3.20.3-0.30.3
Bone: elastic displacement1.01.12.1-0.91.01.0-1.11.0-1.00.80.81.31.31.20.8-0.8-0.90.91.40.91.30.9-0.71.2-1.21.2
Bone: elastic work0.40.51.91.3-1.10.20.7-0.70.9-1.1-1.20.0-0.60.00.2-0.30.0-0.00.2-1.4-0.7-0.0-1.1-0.40.4-0.4
Bone: endosteal estimation14.631.751.15.2-5.1-7.16.2-6.05.6-4.6-4.9-6.9-5.5-6.1-6.16.15.5-5.5-6.8-3.7-4.8-5.15.1-5.45.4-5.4
Bone: endosteal perimeter14.229.444.95.5-4.8-6.75.7-5.75.2-4.0-4.4-6.4-5.2-6.0-6.06.05.5-5.6-6.6-3.3-4.7-5.25.1-5.35.3-5.3
Epididymis fat weight0.92.18.20.6-2.00.91.0-1.41.9-2.3-2.40.1-1.40.21.3-1.3-0.70.70.1-2.9-1.90.6-2.3-0.60.6-0.6
Delta time in closed arm before/after self-admin0.20.20.50.60.2-0.2-0.10.1-0.30.70.6-0.10.3-0.0-0.50.50.1-0.2-0.50.50.3-0.10.6-0.70.7-0.7
Delta time in open arm before/after self-admin0.80.81.4-1.20.90.9-0.91.1-0.90.91.01.00.80.70.8-0.7-0.80.71.01.00.50.4-0.70.9-0.90.9
Diff in mean of infusions in LGA sessions1.61.83.0-1.60.61.7-1.11.1-1.00.00.61.51.01.51.6-1.7-1.31.41.70.31.11.5-1.61.6-1.61.6
Delay discount exponential model param0.30.41.5-0.6-0.30.1-0.10.00.0-0.5-0.40.10.10.70.9-0.9-1.01.10.3-0.40.41.2-0.90.2-0.20.2
Extinction: sum of active levers before priming0.10.10.50.7-0.60.30.4-0.30.3-0.5-0.30.3-0.00.20.2-0.2-0.0-0.00.2-0.5-0.20.1-0.4-0.10.1-0.1
Active lever presses in extinction session 61.31.33.51.3-1.4-0.91.4-1.41.3-1.9-1.4-1.1-1.3-1.0-0.80.71.1-1.0-0.9-1.5-1.1-1.00.3-0.70.7-0.7
Bone: final force2.54.08.72.9-2.1-1.92.2-2.32.2-1.8-2.2-1.9-2.1-2.2-2.02.02.1-2.1-1.7-1.8-2.1-2.00.7-1.61.6-1.6
Bone: final moment2.64.28.62.9-2.2-1.92.3-2.42.3-1.9-2.3-2.0-2.2-2.2-2.12.12.1-2.1-1.8-1.9-2.1-2.00.7-1.61.6-1.6
Food consumed during 24 hour testing period1.41.75.71.2-2.2-0.31.4-1.41.7-2.2-2.1-0.8-1.8-0.50.2-0.20.1-0.0-0.4-2.4-1.70.1-1.5-0.40.4-0.4
Glucose1.01.62.4-1.51.51.1-1.41.5-1.51.21.41.31.41.21.1-1.1-0.80.81.21.31.40.9-0.51.4-1.41.4
Heart weight0.10.10.40.60.4-0.2-0.30.3-0.10.50.20.10.2-0.2-0.20.30.3-0.40.30.50.2-0.50.30.5-0.50.5
Delay discount hyperbolic model param0.30.41.6-0.6-0.30.0-0.10.00.1-0.5-0.5-0.00.00.70.9-1.0-1.01.10.3-0.50.41.3-0.90.1-0.10.1
Intermittent access intake day 1-15 change0.50.41.80.2-0.4-0.80.5-0.30.4-0.5-0.4-0.9-0.5-0.30.1-0.1-0.20.2-0.9-0.4-0.40.40.7-1.41.4-1.4
Intermittent access intake escalation0.30.21.10.0-0.1-0.50.3-0.10.2-0.3-0.1-0.6-0.2-0.10.1-0.2-0.20.2-0.7-0.1-0.10.30.7-1.11.1-1.1
Intermittent access intake escalation 21.51.44.00.7-0.9-1.31.2-1.01.1-1.3-1.0-1.6-1.2-0.9-0.40.30.4-0.4-1.6-1.1-1.0-0.21.2-2.02.0-2.0
Intermitt. access day 1 inactive lever presses2.02.26.52.6-1.9-1.81.7-1.51.5-1.5-1.3-1.4-1.3-1.4-1.92.01.7-1.7-1.4-1.2-1.0-1.20.1-0.40.4-0.4
Intermitt. access day 15 inactive lever presses0.70.82.51.3-1.6-0.21.2-1.21.2-1.3-1.3-0.4-0.8-0.2-0.30.30.2-0.2-0.5-1.4-0.80.1-0.9-0.80.8-0.8
Intermitt. access escalation Index2.42.15.9-2.32.20.3-2.02.0-2.21.52.40.61.40.90.9-0.8-1.01.00.91.81.70.80.11.1-1.11.1
Intermittent access day 1 total infusions0.70.81.50.4-1.1-0.71.0-1.00.9-1.1-0.9-0.6-1.0-1.0-1.11.11.1-1.1-0.2-0.7-0.9-1.2-0.10.9-0.90.9
Intermittent access day 15 total infusions0.70.81.60.2-1.0-1.21.1-0.90.9-1.2-0.9-1.2-1.2-1.1-0.70.70.8-0.7-0.7-0.8-1.1-0.80.5-0.20.2-0.2
Intermittent access terminal intake (last 3 days)2.52.74.51.1-1.9-2.02.0-1.81.7-2.0-1.6-2.1-2.1-1.9-1.41.41.5-1.4-1.7-1.6-1.9-1.51.1-1.11.1-1.1
Intermittent access total infusions2.73.04.61.6-2.1-1.82.1-1.91.9-2.0-1.8-1.8-2.0-2.0-1.91.91.9-1.9-1.5-1.6-1.9-1.90.8-0.60.6-0.6
Intermittent access day 1 locomotion2.72.84.91.7-2.2-1.42.0-2.12.0-2.1-1.8-1.5-2.0-1.7-1.71.71.8-1.8-1.2-1.9-1.9-1.70.1-0.40.4-0.4
Intermittent access day 15 total locomotion5.45.810.02.4-3.0-2.23.1-3.23.0-3.0-2.9-2.4-2.7-2.4-2.12.12.2-2.1-2.2-2.6-2.7-1.71.1-1.71.7-1.7
Intermittent access total locomotion8.39.515.53.5-3.9-2.63.8-3.93.8-3.9-3.7-2.9-3.6-3.0-2.72.62.9-2.8-2.5-3.6-3.5-2.50.5-1.91.9-1.9
Intermittent access standard deviation1.31.43.01.7-1.4-0.91.2-1.11.3-1.6-1.4-1.1-1.3-1.1-0.80.81.1-1.1-1.0-1.3-1.3-1.00.2-1.11.1-1.1
Left kidney weight0.31.04.20.20.30.7-0.50.6-0.20.1-0.31.00.70.60.2-0.2-0.10.11.60.30.90.4-1.72.1-2.12.1
Right kidney weight0.10.41.50.4-0.2-0.1-0.10.20.3-0.7-0.70.1-0.1-0.1-0.10.10.4-0.40.8-0.40.2-0.4-1.21.2-1.21.2
Cocaine induced anxiety0.10.10.4-0.10.3-0.00.00.1-0.20.30.30.10.2-0.1-0.40.40.2-0.20.20.30.2-0.10.20.6-0.60.6
Post-drug Anxiety0.70.81.5-1.01.11.0-0.91.0-1.01.11.21.01.00.60.5-0.5-0.60.60.81.10.80.60.11.0-1.01.0
Baseline Anxiety1.51.53.4-1.61.11.8-1.41.3-1.10.80.81.61.21.41.7-1.7-1.31.31.50.70.91.1-0.80.7-0.70.7
Tail length1.64.86.42.4-2.3-2.42.2-2.22.4-2.3-2.4-2.4-2.5-2.5-2.01.92.5-2.4-2.2-2.1-2.4-2.31.1-1.71.7-1.7
Length with tail1.55.67.82.8-2.1-2.72.4-2.22.2-1.6-2.0-2.5-2.2-2.6-2.72.72.6-2.6-2.7-1.5-2.1-2.62.0-2.32.3-2.3
Length without tail0.20.41.60.7-0.3-0.40.6-0.50.40.2-0.1-0.4-0.1-0.3-0.60.70.1-0.1-1.00.0-0.2-0.10.8-1.31.3-1.3
Times rat made contact with spout0.40.50.90.6-0.8-0.90.6-0.80.8-0.9-0.9-0.9-0.8-0.5-0.30.20.4-0.4-0.7-0.9-0.6-0.40.1-0.60.6-0.6
Lifetime Intake2.83.25.81.9-2.4-1.72.2-2.12.1-2.2-2.1-1.7-2.1-1.9-2.02.01.9-1.9-1.2-1.9-1.9-1.80.2-0.40.4-0.4
Liver weight, left0.40.61.01.0-0.4-0.80.8-0.80.7-0.3-0.6-0.6-0.4-0.7-0.80.80.9-0.9-1.0-0.3-0.4-0.91.0-1.01.0-1.0
Liver weight, right0.10.10.40.0-0.00.5-0.10.1-0.00.30.10.60.40.30.3-0.3-0.0-0.00.50.10.1-0.1-0.50.3-0.30.3
Locomotor activity1.01.63.91.7-1.6-1.51.2-1.11.3-2.0-1.8-1.2-1.3-1.2-1.31.31.4-1.4-0.3-1.4-0.7-0.9-0.60.7-0.70.7
Locomotor testing distance0.81.34.02.0-1.6-1.31.1-1.01.2-1.8-1.7-1.0-1.1-1.0-1.11.11.2-1.1-0.2-1.3-0.5-0.6-0.70.7-0.70.7
Locomotor testing rearing0.50.72.51.6-1.4-0.90.9-0.91.0-1.3-1.5-0.7-0.50.1-0.10.1-0.00.1-0.3-1.40.10.6-1.2-0.30.3-0.3
Locomotion in novel chamber0.30.42.0-0.10.60.20.10.2-0.61.40.90.50.90.2-0.70.80.1-0.2-0.21.30.70.10.60.1-0.10.1
Locomotion in novel chamber post-restriction2.53.04.71.8-1.3-1.62.2-1.91.6-0.7-1.2-1.6-1.5-1.9-2.12.21.7-1.7-2.1-0.8-1.7-1.61.8-2.02.0-2.0
Fecal boli incidents, locomotor time 10.30.31.5-0.60.90.4-0.60.6-0.61.20.70.40.60.1-0.10.1-0.20.10.01.00.40.01.00.1-0.10.1
Change in fecal boli incidents, locomotor task0.20.20.50.3-0.4-0.40.3-0.30.4-0.7-0.4-0.4-0.6-0.7-0.20.10.6-0.5-0.1-0.4-0.7-0.70.60.0-0.00.0
Time >=10cm from walls, locomotor time 11.21.32.6-1.61.40.6-1.11.2-1.21.21.10.91.50.90.3-0.3-0.70.70.81.61.60.90.41.4-1.41.4
Bouts of movement, locomotor time 10.40.41.8-0.5-0.21.1-0.0-0.30.3-0.4-0.50.70.00.81.0-1.0-0.80.80.8-0.7-0.20.7-1.4-0.10.1-0.1
Total resting periods, locomotor time 10.30.31.1-0.4-0.11.0-0.0-0.30.3-0.2-0.40.60.10.70.9-0.9-0.70.70.6-0.6-0.30.6-1.0-0.20.2-0.2
Rest time, locomotor task time 10.40.51.1-0.90.80.9-0.70.4-0.60.90.70.91.01.00.7-0.7-0.70.70.50.60.70.6-0.2-0.00.0-0.0
Distance moved, locomotor task time 10.30.31.10.7-1.0-0.20.5-0.50.5-1.0-0.6-0.3-0.8-0.3-0.0-0.0-0.10.1-0.3-1.0-0.70.3-0.6-0.10.1-0.1
Vertical activity count, locomotor time 10.10.10.60.8-0.7-0.30.5-0.20.3-0.3-0.3-0.3-0.5-0.3-0.10.2-0.10.1-0.3-0.5-0.50.3-0.4-0.20.2-0.2
Time >=10cm from walls, locomotor time 21.31.34.8-0.80.41.1-0.70.7-0.70.60.31.11.11.91.5-1.4-1.91.90.90.11.32.2-1.40.4-0.40.4
Bouts of movement, locomotor time 21.11.25.6-0.20.11.7-0.60.5-0.30.20.11.30.41.41.6-1.7-1.51.51.3-0.60.21.4-2.40.6-0.60.6
Total resting periods, locomotor time 21.21.24.6-0.50.41.7-0.90.6-0.50.60.41.40.71.41.5-1.5-1.41.41.4-0.20.51.2-2.10.8-0.80.8
Rest time, locomotor task time 25.05.710.6-3.03.02.5-2.82.5-2.63.32.92.72.92.21.9-1.9-1.81.82.12.92.41.5-0.12.0-2.02.0
Distance moved, locomotor task time 20.80.93.30.7-1.3-0.00.7-0.50.6-1.7-1.0-0.3-0.70.50.8-0.8-1.01.0-0.0-1.7-0.41.3-1.8-0.50.5-0.5
Vertical activity count, locomotor time 22.22.47.41.9-2.5-1.31.9-1.51.7-2.7-2.2-1.5-1.9-0.7-0.30.30.2-0.1-1.0-2.7-1.50.3-1.2-1.21.2-1.2
Light reinforcement 10.50.95.60.7-1.01.10.3-0.40.6-1.2-1.10.9-0.40.30.6-0.7-0.30.41.2-1.4-0.70.6-2.41.1-1.11.1
Light reinforcement 20.20.20.90.9-0.40.90.1-0.20.3-0.3-0.30.8-0.0-0.1-0.10.00.3-0.40.5-0.5-0.6-0.4-0.70.2-0.20.2
Bone: marrow area14.230.749.75.1-5.0-7.06.1-6.05.5-4.6-4.8-6.8-5.4-6.0-6.05.95.4-5.4-6.8-3.7-4.7-5.05.1-5.45.4-5.4
Bone: maximum diameter5.910.915.84.0-2.8-4.03.4-3.33.1-2.3-2.6-3.6-3.1-3.9-4.04.03.8-3.8-3.6-1.8-2.9-3.72.9-2.82.8-2.8
Bone: maximum force3.76.415.03.9-2.8-2.32.8-2.72.9-2.5-2.8-2.3-2.7-2.8-2.52.52.7-2.7-2.1-2.4-2.7-2.60.8-1.81.8-1.8
Bone: maximum moment3.96.814.73.8-2.9-2.42.9-2.83.0-2.6-2.9-2.4-2.8-2.8-2.52.52.7-2.7-2.2-2.5-2.8-2.60.9-1.91.9-1.9
Mean time between licks in bursts0.10.10.50.0-0.40.10.3-0.60.6-0.7-0.6-0.1-0.5-0.3-0.10.00.1-0.1-0.2-0.6-0.7-0.0-0.1-0.10.1-0.1
Mean num. licks in bursts0.10.10.40.5-0.4-0.10.3-0.30.4-0.4-0.5-0.2-0.6-0.20.2-0.20.0-0.0-0.2-0.6-0.7-0.1-0.3-0.20.2-0.2
Cd content in liver1.31.43.2-1.81.71.2-1.21.3-1.41.81.61.01.41.01.0-1.0-1.11.00.71.51.11.00.70.2-0.20.2
Co content in liver0.40.51.9-1.41.10.5-0.50.3-0.81.10.80.50.90.70.2-0.2-0.50.40.21.10.90.50.7-0.20.2-0.2
Cu content in liver0.10.10.3-0.1-0.2-0.30.4-0.60.4-0.2-0.3-0.4-0.3-0.4-0.20.20.3-0.3-0.4-0.1-0.4-0.40.6-0.40.4-0.4
Fe content in liver0.00.10.30.4-0.0-0.30.3-0.30.20.2-0.2-0.10.1-0.2-0.50.50.1-0.00.10.20.20.10.10.2-0.20.2
K content in liver0.50.51.70.7-0.2-0.60.5-0.50.30.40.1-0.5-0.2-0.8-1.21.20.8-0.8-1.00.4-0.3-0.71.3-0.60.6-0.6
Mg content in liver0.20.21.3-0.1-0.0-0.20.4-0.40.20.30.1-0.3-0.2-0.4-0.60.60.2-0.3-0.70.2-0.3-0.31.1-0.80.8-0.8
Mn content in liver0.70.82.70.5-0.1-0.90.6-0.50.3-0.1-0.0-0.7-0.5-1.3-1.61.61.4-1.4-0.80.4-0.5-1.41.4-0.10.1-0.1
Na content in liver0.30.41.20.00.5-0.1-0.40.5-0.60.90.60.20.6-0.3-0.80.80.3-0.4-0.01.10.6-0.30.80.8-0.80.8
Rb content in liver0.50.61.9-0.91.1-0.1-0.80.8-1.01.01.20.20.8-0.1-0.40.40.0-0.00.11.40.9-0.21.10.7-0.70.7
Se content in liver1.92.36.1-1.12.01.3-2.01.8-2.02.52.31.72.01.10.5-0.4-0.40.41.32.51.70.10.31.2-1.21.2
Sr content in liver0.10.10.3-0.1-0.6-0.00.3-0.20.3-0.5-0.5-0.0-0.3-0.1-0.10.00.3-0.3-0.1-0.4-0.3-0.1-0.30.1-0.10.1
Zn content in liver0.70.72.9-0.51.20.1-0.80.5-0.91.51.20.61.0-0.0-0.60.60.7-0.80.21.70.8-1.01.10.5-0.50.5
Bone: minimum diameter11.721.929.35.4-4.8-5.35.1-5.14.9-4.2-4.6-5.3-5.1-5.2-4.54.54.5-4.5-5.1-3.9-4.8-4.43.0-4.34.3-4.3
Time in familiar zone, hab. session 11.21.22.01.1-1.1-1.21.2-1.21.2-0.8-1.0-1.3-1.2-1.1-0.80.80.8-0.7-1.4-0.8-1.2-0.80.9-1.21.2-1.2
Time in novel zone, hab. session 11.11.12.1-1.10.91.0-1.11.1-0.90.30.61.10.91.11.1-1.1-0.91.01.40.31.00.9-1.31.3-1.31.3
Total zone transitions, hab. session 10.50.62.21.0-1.2-0.21.0-1.01.2-1.4-1.5-0.2-0.7-0.2-0.20.20.1-0.10.1-1.3-0.60.3-1.10.5-0.50.5
Total locomotion distance, hab. session 11.11.64.81.5-1.9-0.81.7-1.61.9-2.0-2.2-0.8-1.4-0.8-0.70.70.7-0.6-0.3-1.8-1.2-0.2-1.10.3-0.30.3
Locomotion velocity, hab. session 11.01.44.11.5-1.8-0.81.7-1.61.8-1.8-2.0-0.8-1.3-0.8-0.90.90.7-0.7-0.5-1.6-1.2-0.3-0.70.1-0.10.1
Time in familiar zone, hab. session 21.11.22.91.7-1.2-1.40.9-1.11.0-0.7-0.9-1.3-0.9-0.9-0.90.90.8-0.8-1.4-0.8-0.7-0.70.8-1.41.4-1.4
Time in novel zone, hab. session 20.60.61.9-1.40.90.9-0.50.7-0.60.50.60.80.50.50.6-0.6-0.50.51.00.70.30.4-0.31.1-1.11.1
Total zone transitions, hab. session 20.40.62.90.2-0.70.50.0-0.10.3-0.8-0.70.50.00.80.8-0.8-0.80.90.7-0.90.21.2-1.70.9-0.90.9
Total locomotion distance, hab. session 20.70.93.21.3-1.60.01.1-1.11.3-1.6-1.6-0.2-1.0-0.10.2-0.3-0.10.10.0-1.8-1.00.3-1.5-0.00.0-0.0
Locomotion velocity, hab. session 20.50.72.51.2-1.40.20.8-0.91.1-1.4-1.40.0-0.80.10.3-0.4-0.20.20.2-1.6-0.90.4-1.50.1-0.10.1
Novel to familiar place preference ratio2.12.23.71.0-1.3-1.41.9-1.81.7-1.5-1.6-1.5-1.6-1.7-1.61.61.7-1.7-1.3-1.2-1.5-1.51.2-1.11.1-1.1
Novelty place preference1.31.42.60.7-1.0-1.11.6-1.51.4-1.3-1.4-1.2-1.2-1.3-1.31.21.3-1.3-1.0-1.0-1.1-1.00.9-0.80.8-0.8
Time in novel zone, NPP test1.11.22.30.6-0.9-1.11.5-1.41.3-1.2-1.3-1.1-1.1-1.2-1.21.21.3-1.2-0.9-0.9-1.0-0.90.9-0.60.6-0.6
Total zone transitions, NPP test0.30.41.90.9-0.50.3-0.10.10.2-0.4-0.50.5-0.00.30.2-0.2-0.10.10.8-0.50.00.3-1.41.3-1.31.3
Total locomotion distance, NPP test0.60.92.81.7-1.5-0.61.0-1.11.3-1.4-1.5-0.6-1.1-0.5-0.30.30.4-0.4-0.3-1.5-1.0-0.2-0.9-0.10.1-0.1
Locomotion velocity, NPP test0.40.62.21.5-1.2-0.10.7-0.71.0-1.1-1.2-0.1-0.8-0.30.0-0.00.2-0.20.2-1.2-0.9-0.2-1.20.3-0.30.3
Intraocular pressure0.30.42.8-0.1-0.10.0-0.10.3-0.1-0.10.00.3-0.0-0.10.2-0.2-0.30.30.60.20.00.4-0.91.7-1.71.7
Delta distance traveled before/after self-admin0.50.62.7-0.0-0.20.4-0.50.5-0.3-0.3-0.20.50.20.70.8-0.7-0.91.00.9-0.40.51.2-1.61.0-1.01.0
Delta ambulatory time before/after self-admin0.20.20.80.3-0.6-0.50.1-0.20.3-0.9-0.5-0.5-0.6-0.30.1-0.1-0.10.10.0-0.7-0.30.2-0.60.2-0.20.2
Parametrial fat weight1.12.13.60.3-1.1-1.01.6-1.71.6-1.5-1.5-1.4-1.7-1.6-1.00.91.2-1.2-1.5-1.2-1.9-1.31.2-1.91.9-1.9
Pavlov. Cond. lever latency0.50.62.3-1.51.30.7-0.60.7-0.81.01.20.50.60.20.7-0.7-0.60.60.21.10.20.30.90.3-0.30.3
Pavlov. Cond. magazine entry latency1.51.93.61.4-1.4-1.81.6-1.51.5-1.3-1.5-1.5-1.4-1.6-1.91.91.7-1.6-1.3-1.0-1.0-1.40.8-0.50.5-0.5
Pavlov. Cond. change in total contacts1.11.22.61.6-1.4-1.31.1-1.11.2-1.3-1.4-1.1-1.0-0.9-1.21.21.2-1.2-0.8-1.2-0.6-1.1-0.2-0.70.7-0.7
Pavlov. Cond. index score1.01.32.61.6-1.5-1.41.3-1.21.2-1.1-1.4-1.1-1.1-1.1-1.51.51.3-1.3-0.9-1.1-0.7-1.10.1-0.50.5-0.5
Pavlov. Cond. latency score0.70.82.41.5-1.3-1.01.0-0.91.0-0.9-1.2-0.8-0.8-0.7-1.11.10.9-1.0-0.6-1.0-0.5-0.7-0.3-0.30.3-0.3
Pavlov. Cond. lever contacts0.30.41.81.3-1.1-0.10.3-0.30.5-0.6-0.9-0.0-0.20.40.00.0-0.20.20.1-1.10.10.5-1.4-0.30.3-0.3
Pavlov. Cond. magazine entry number1.31.64.0-0.91.01.7-1.41.3-1.10.81.11.41.11.62.0-2.0-1.81.81.20.50.81.6-1.20.4-0.40.4
Pavlov. Cond. intertrial magazine entries2.32.85.22.3-1.6-1.51.8-1.81.9-1.6-1.7-1.5-1.7-2.0-1.91.92.1-2.1-1.3-1.3-1.8-2.01.0-0.80.8-0.8
Pavlov. Cond. lever-magazine prob. diff.0.81.02.21.5-1.3-1.21.1-1.11.1-1.0-1.2-1.0-0.9-1.0-1.41.41.2-1.2-0.7-0.9-0.6-1.0-0.0-0.40.4-0.4
Pavlov. Cond. response bias1.01.22.71.3-1.2-1.41.2-1.11.1-1.0-1.2-1.1-0.9-1.1-1.61.61.4-1.4-0.9-0.8-0.6-1.20.4-0.40.4-0.4
Pavlov. Cond. lever latency0.50.71.8-0.90.41.3-0.60.6-0.60.50.51.00.61.01.3-1.3-1.21.20.70.20.31.2-0.50.2-0.20.2
Pavlov. Cond. magazine entry latency2.32.64.7-1.92.21.2-2.02.1-2.22.12.11.41.91.40.9-0.8-1.21.21.32.12.01.0-0.41.4-1.41.4
Pavlov. Cond. change in total contacts0.30.41.31.0-0.1-1.20.1-0.1-0.00.20.2-0.8-0.1-0.7-1.01.10.7-0.8-0.80.40.1-0.80.8-0.40.4-0.4
Pavlov. Cond. index score0.10.20.5-0.10.5-0.7-0.40.4-0.50.50.5-0.30.2-0.2-0.60.70.3-0.4-0.10.60.6-0.50.20.3-0.30.3
Pavlov. Cond. latency score0.20.30.9-0.20.7-0.6-0.60.7-0.70.70.8-0.20.5-0.1-0.60.60.2-0.30.00.90.8-0.40.30.5-0.50.5
Pavlov. Cond. lever contacts0.40.51.20.8-0.7-1.10.7-0.70.7-0.8-0.8-0.9-0.8-0.8-0.90.90.9-0.9-0.4-0.6-0.5-0.9-0.1-0.20.2-0.2
Pavlov. Cond. magazine entry number2.83.55.92.0-2.4-1.32.3-2.42.4-2.3-2.4-1.7-2.2-1.6-1.00.91.4-1.4-1.6-2.3-2.3-1.20.5-1.81.8-1.8
Pavlov. Cond. intertrial magazine entries8.310.917.64.0-4.2-2.73.9-3.83.9-3.6-3.8-3.2-3.9-3.0-1.91.82.5-2.5-3.3-3.8-4.0-2.40.9-3.43.4-3.4
Pavlov. Cond. lever-magazine prob. diff.0.20.20.6-0.10.6-0.6-0.40.5-0.60.60.6-0.20.4-0.1-0.60.70.3-0.4-0.00.80.6-0.50.30.3-0.30.3
Pavlov. Cond. response bias0.10.20.60.4-0.2-0.80.2-0.20.2-0.2-0.2-0.6-0.3-0.5-0.70.80.6-0.6-0.3-0.1-0.1-0.70.1-0.10.1-0.1
Time in closed arm before self-admin0.30.31.6-0.90.2-0.3-0.40.5-0.3-0.7-0.1-0.2-0.1-0.00.1-0.10.1-0.00.7-0.10.40.0-0.51.3-1.31.3
Time in closed arm after self-admin0.10.10.4-0.60.4-0.7-0.50.4-0.50.10.5-0.40.20.0-0.20.20.00.1-0.20.30.60.10.50.1-0.10.1
Time in open arm before self-admin1.01.01.9-1.10.91.1-1.01.0-1.21.41.11.01.11.21.0-1.0-1.41.30.70.81.11.4-0.40.4-0.40.4
Time in open arm after self-admin0.40.51.7-0.40.51.1-0.40.5-0.61.31.01.10.80.80.6-0.5-0.90.80.50.80.30.7-0.50.2-0.20.2
Bone: periosteal estimation11.022.731.95.4-4.8-5.65.3-5.25.0-4.4-4.7-5.5-5.0-5.2-4.94.94.7-4.7-5.1-3.8-4.5-4.43.1-4.14.1-4.1
Bone: periosteal perimeter5.18.512.83.6-2.6-3.62.9-3.02.8-2.1-2.4-3.2-2.7-3.3-3.53.53.2-3.3-3.2-1.7-2.4-3.22.4-2.52.5-2.5
Bone: post-yield work2.63.57.42.7-1.9-2.01.9-1.81.8-1.5-1.6-2.0-1.9-1.9-1.91.91.7-1.7-2.2-1.4-1.8-1.71.1-2.12.1-2.1
Progressive ratio test 1 active lever presses2.93.06.01.5-2.3-1.81.9-2.01.9-2.5-2.0-1.8-2.2-1.9-1.81.91.9-1.8-1.1-1.9-1.8-1.9-0.1-0.20.2-0.2
Progressive ratio test 1 breakpoint3.33.47.21.6-2.6-1.92.0-2.12.1-2.7-2.2-1.9-2.4-2.0-1.81.81.9-1.8-1.1-2.2-2.0-1.9-0.3-0.10.1-0.1
Progressive ratio test 1 inactive lever presses3.43.86.72.1-2.6-2.12.2-2.12.2-2.2-2.2-1.8-2.1-2.0-2.52.52.2-2.2-1.3-2.0-1.8-2.0-0.30.0-0.00.0
Progressive ratio test 2 active lever presses3.13.36.01.4-1.8-2.02.0-2.01.8-1.6-1.5-1.8-1.8-2.2-2.42.42.3-2.3-1.8-1.1-1.8-2.21.6-0.70.7-0.7
Progressive ratio test 2 breakpoint3.43.86.21.5-2.0-2.22.2-2.22.0-1.8-1.7-2.1-2.0-2.3-2.52.52.3-2.3-2.0-1.4-2.0-2.21.6-1.01.0-1.0
Progressive ratio test 2 inactive lever presses4.55.27.82.2-2.6-2.12.7-2.62.6-2.2-2.3-2.1-2.4-2.6-2.82.82.7-2.7-2.0-1.7-2.5-2.61.6-1.11.1-1.1
Incentive Sensitization - Responses1.21.33.00.9-0.8-1.21.2-1.10.9-0.4-0.5-1.0-0.7-1.2-1.61.61.4-1.4-1.5-0.2-0.8-1.21.7-1.01.0-1.0
Incentive Sensitization - Breakpoint1.21.23.70.8-0.7-1.21.1-1.00.8-0.4-0.4-1.0-0.6-1.2-1.61.61.4-1.4-1.5-0.1-0.7-1.11.9-1.01.0-1.0
Sum of active levers in priming session hrs 5-60.40.41.4-1.00.5-0.0-0.60.5-0.6-0.20.60.10.40.10.2-0.2-0.10.20.60.40.70.20.11.2-1.21.2
Progressive ratio0.50.52.2-0.31.00.3-0.50.7-0.91.41.30.30.7-0.0-0.30.40.0-0.1-0.41.40.3-0.31.5-0.40.4-0.4
Food seeking constrained by brief footshock2.02.44.61.5-1.6-2.11.4-1.41.3-1.8-1.5-2.1-1.7-1.4-1.21.10.9-0.9-2.1-1.4-1.2-0.61.5-2.02.0-2.0
Seeking ratio, punishment vs. effort1.31.65.21.1-1.8-1.41.3-1.51.6-2.3-2.0-1.5-1.5-0.8-0.40.30.6-0.6-0.9-2.0-1.0-0.2-0.4-0.80.8-0.8
Retroperitoneal fat weight1.75.418.62.2-3.6-0.62.8-3.23.4-3.7-3.9-1.3-2.5-0.6-0.20.00.4-0.3-1.3-4.3-2.60.2-1.9-1.71.7-1.7
Reaction time number correct0.60.82.2-1.21.30.5-0.80.8-0.81.11.00.80.90.20.1-0.0-0.30.30.81.40.70.40.61.5-1.51.5
Reaction time mean minus median0.20.20.9-1.00.30.6-0.40.5-0.50.20.50.20.10.40.8-0.9-0.70.70.30.20.00.6-0.3-0.20.2-0.2
Reaction time mean minus median AUC0.10.21.2-1.10.50.1-0.20.4-0.40.30.5-0.1-0.0-0.30.1-0.10.00.00.20.8-0.0-0.20.50.3-0.30.3
Reaction time num false alarms2.02.75.52.4-1.4-2.11.6-1.51.5-1.2-1.4-1.7-1.3-1.9-2.22.22.2-2.3-1.6-0.8-1.1-2.11.4-0.70.7-0.7
Reaction time num false alarms AUC2.73.76.22.4-1.6-2.41.9-1.81.9-1.6-1.7-2.1-1.8-2.3-2.32.32.5-2.5-1.9-1.2-1.5-2.41.7-1.11.1-1.1
Reaction time trials correct on left0.60.82.2-1.21.30.5-0.80.8-0.81.11.00.80.90.20.1-0.0-0.30.30.81.40.70.40.61.5-1.51.5
Reaction time trials on left0.50.82.1-1.21.30.4-0.70.7-0.71.00.90.70.80.10.10.0-0.20.20.71.30.60.30.71.4-1.41.4
Reaction time mean0.20.31.8-1.30.8-0.2-0.30.4-0.50.50.7-0.10.4-0.2-0.20.20.2-0.1-0.11.10.5-0.11.20.1-0.10.1
Reaction time mean AUC0.20.32.4-1.50.9-0.0-0.50.5-0.60.40.7-0.00.50.10.1-0.1-0.20.20.11.00.60.20.90.3-0.30.3
Median of all reaction times0.20.32.3-1.20.7-0.5-0.10.1-0.30.30.4-0.30.3-0.4-0.60.60.5-0.5-0.31.00.4-0.41.50.2-0.20.2
Reaction time omissions0.30.51.0-0.0-0.5-0.60.8-0.70.7-0.6-0.6-0.8-0.9-0.9-0.50.50.7-0.7-0.8-0.4-1.0-0.80.8-0.50.5-0.5
Reaction time false alarm rate2.23.15.72.4-1.8-2.21.7-1.71.7-1.7-1.7-2.0-1.7-1.7-1.81.81.9-2.0-1.8-1.5-1.3-1.91.0-1.51.5-1.5
Reaction time premature initiation rate0.81.14.32.1-1.6-0.41.3-1.21.2-1.3-1.2-0.5-1.0-0.7-0.70.70.9-0.9-0.5-1.5-1.1-0.8-0.7-0.70.7-0.7
Reaction time premature initiations0.20.31.51.2-0.8-0.20.7-0.60.7-0.7-0.5-0.1-0.5-0.5-0.50.50.7-0.7-0.0-0.6-0.7-0.6-0.30.0-0.00.0
Std. dev. reaction times0.20.20.8-0.90.3-0.2-0.00.1-0.30.20.6-0.4-0.1-0.20.1-0.1-0.00.0-0.50.5-0.0-0.10.9-0.80.8-0.8
Reaction time trials completed0.50.82.1-1.21.30.4-0.70.7-0.71.00.90.70.80.10.10.0-0.20.20.71.30.60.30.71.4-1.41.4
Reaction time trials AUC0.40.61.7-1.21.20.4-0.60.7-0.61.00.80.60.80.10.10.0-0.20.20.71.20.50.30.71.3-1.31.3
Run reversals in cocaine runway, females2.32.28.8-0.80.02.4-0.90.5-0.3-0.3-0.21.70.72.12.5-2.5-2.12.01.5-0.70.31.8-3.0-0.10.1-0.1
Run reversals in cocaine runway, males0.10.10.5-0.30.50.20.10.0-0.20.60.50.20.3-0.1-0.50.60.2-0.3-0.10.60.1-0.30.7-0.00.0-0.0
Latency to leave start box in cocaine runway1.01.12.1-0.80.70.9-0.80.7-0.80.70.71.11.11.51.0-1.0-1.21.21.10.31.21.4-1.41.2-1.21.2
Latency to leave start box in cocaine runway, F1.71.93.4-0.71.31.1-1.11.4-1.41.51.51.51.71.60.7-0.7-1.11.11.51.11.81.3-1.31.8-1.81.8
Latency to leave start box in cocaine runway, M0.40.41.3-0.3-0.50.40.1-0.60.4-0.6-0.7-0.0-0.20.71.0-1.1-0.80.90.0-0.9-0.20.9-1.0-0.40.4-0.4
Std. dev. time between licks in bursts0.30.41.1-0.3-0.01.0-0.30.1-0.0-0.2-0.20.70.00.60.9-1.0-0.90.90.6-0.4-0.10.8-1.00.4-0.40.4
Total sessions with >9 infusions0.60.62.30.2-0.60.00.1-0.10.1-0.7-0.10.2-0.4-0.5-0.60.61.0-0.90.8-0.3-0.3-1.1-1.31.5-1.51.5
Short access day 1 total inactive lever presses0.50.61.61.2-1.2-0.31.1-0.91.0-0.4-0.7-0.2-0.5-0.5-1.21.30.8-0.9-0.4-0.8-0.6-0.6-0.50.2-0.20.2
Short access day 10 total inactive lever presses1.11.32.71.7-1.5-0.61.5-1.41.6-1.2-1.5-0.7-1.0-0.7-0.80.90.8-0.8-0.9-1.4-1.2-0.7-0.2-1.21.2-1.2
Short access day 1 total infusions1.01.12.30.8-1.4-0.11.0-0.81.0-1.4-1.00.1-0.5-0.6-1.41.41.2-1.20.5-0.8-0.5-0.9-0.71.5-1.51.5
Short access day 10 total infusions5.15.712.32.9-3.5-1.83.0-3.03.1-3.2-3.2-2.0-3.0-2.1-1.91.91.8-1.8-1.6-3.3-2.9-1.7-0.5-1.01.0-1.0
Short access total infusions2.52.86.32.2-2.5-1.52.0-2.02.0-2.2-2.0-1.4-1.9-1.6-1.92.01.8-1.7-0.8-2.0-1.6-1.5-0.50.0-0.00.0
Short access day 1 locomotion3.03.27.02.3-2.6-0.92.1-2.12.3-2.6-2.3-1.1-2.2-1.7-1.61.61.8-1.8-0.6-2.5-2.3-1.6-0.7-0.00.0-0.0
Short access day 10 total locomotion8.08.916.13.8-4.0-2.33.5-3.63.6-3.9-3.6-2.6-3.4-2.7-2.42.32.7-2.7-2.4-3.7-3.4-2.20.3-2.22.2-2.2
Short access total locomotion4.24.410.22.9-3.1-1.32.3-2.52.7-3.2-2.8-1.6-2.6-1.9-1.51.51.9-1.8-1.0-3.0-2.5-1.6-1.0-0.60.6-0.6
One hour access (0.3 mA shock)1.11.32.90.5-1.2-1.71.1-1.01.0-1.4-1.2-1.6-1.3-1.4-1.31.31.3-1.2-1.1-0.8-0.9-1.21.1-0.20.2-0.2
Compulsive drug intake0.50.61.6-1.31.1-0.3-0.81.0-0.90.80.7-0.10.6-0.00.00.0-0.20.20.21.20.90.11.20.8-0.80.8
One hour access (shock baseline)0.91.12.21.1-1.5-0.91.3-1.21.2-1.4-1.2-1.0-1.3-1.0-0.90.81.0-0.9-0.8-1.2-1.2-0.90.1-0.60.6-0.6
Social response proportion0.10.10.2-0.20.3-0.5-0.10.0-0.1-0.40.1-0.4-0.2-0.4-0.20.30.4-0.40.00.0-0.0-0.40.50.2-0.20.2
Social responses0.70.93.20.3-1.0-1.40.8-1.00.8-1.8-1.0-1.3-1.3-1.2-0.90.90.9-0.8-0.5-1.1-0.8-0.6-0.10.3-0.30.3
Social time0.30.41.2-0.91.1-0.2-0.90.7-0.80.81.00.00.70.20.1-0.0-0.30.3-0.11.00.80.20.90.2-0.20.2
Soleus weight0.10.20.60.80.2-0.0-0.20.4-0.20.20.10.30.4-0.0-0.40.50.6-0.60.40.20.4-0.6-0.30.5-0.50.5
Bone: stiffness2.13.38.32.9-2.0-1.92.0-1.71.9-1.6-1.8-1.8-2.0-2.1-1.92.01.9-2.0-1.7-1.5-1.9-1.80.7-1.31.3-1.3
Tibialis anterior weight0.41.35.50.5-1.40.90.7-0.71.1-1.7-1.60.3-0.90.71.3-1.4-0.90.90.6-2.3-1.10.8-2.4-0.40.4-0.4
Time to tail flick, vehicle, before self-admin0.80.87.7-0.51.1-0.6-0.50.4-0.71.11.2-0.30.6-0.5-0.80.80.3-0.4-0.91.40.5-0.52.8-0.40.4-0.4
Time to tail flick, vehicle, after self-admin1.31.45.00.80.1-1.10.4-0.30.20.30.1-1.0-0.7-1.6-1.31.31.6-1.6-1.30.4-1.0-2.22.2-1.31.3-1.3
Time to tail flick, test, before self-admin0.40.41.8-1.30.7-0.6-0.30.1-0.3-0.10.6-0.8-0.2-0.50.1-0.1-0.10.1-0.60.4-0.1-0.31.4-0.80.8-0.8
Time to tail flick, test, after self-admin0.50.51.7-0.50.1-1.20.2-0.40.2-0.6-0.1-1.1-0.8-1.2-0.90.91.0-1.0-0.40.0-0.6-1.30.80.3-0.30.3
Delta time to tail flick, vehicle, before/after SA2.52.54.31.5-1.4-1.41.5-1.31.5-1.6-1.6-1.7-2.0-1.8-1.01.01.7-1.7-1.4-1.4-2.0-2.10.7-1.81.8-1.8
Delta time to tail flick, test, before/after SA0.50.41.30.4-0.1-0.70.6-0.40.30.2-0.2-0.5-0.2-0.8-1.11.11.1-1.1-0.40.2-0.3-1.10.70.1-0.10.1
Tibia length0.20.51.80.40.4-0.7-0.20.4-0.30.20.4-0.2-0.0-0.9-0.91.01.3-1.40.10.70.0-1.40.40.8-0.80.8
Ambulatory time before self-admin1.11.23.7-1.01.50.5-1.31.3-1.41.81.60.81.40.70.00.0-0.30.30.51.91.40.20.40.9-0.90.9
Ambulatory time after self-admin0.20.20.6-0.10.4-0.3-0.60.6-0.70.40.70.10.50.1-0.40.40.1-0.10.20.70.8-0.1-0.10.8-0.80.8
Bone: tissue strength1.01.02.1-0.71.20.8-1.11.2-1.11.31.21.11.30.70.2-0.1-0.40.41.01.41.20.4-0.11.2-1.21.2
Total heroin consumption0.40.51.3-0.10.1-1.00.2-0.20.0-0.50.2-0.7-0.2-0.8-1.01.01.1-1.1-0.50.30.2-1.10.90.6-0.60.6
Bone: trabecular number1.11.73.41.8-1.0-1.41.1-1.00.9-0.5-0.6-1.3-1.1-1.6-1.71.71.7-1.8-1.6-0.5-1.3-1.81.1-1.01.0-1.0
Bone: trabecular spacing0.60.71.7-1.10.80.7-0.70.7-0.70.60.50.70.81.11.0-1.0-1.11.20.80.51.01.3-0.50.6-0.60.6
Bone: trabecular thickness1.82.24.72.2-1.4-1.11.3-1.41.4-1.2-1.3-1.3-1.7-1.6-1.21.21.6-1.6-1.4-1.4-1.9-1.90.4-1.61.6-1.6
Bone: trabecular tissue density0.20.31.00.10.51.0-0.50.6-0.40.50.50.90.30.20.5-0.5-0.10.11.00.5-0.0-0.1-0.50.8-0.80.8
Water consumed over 24 hours0.30.41.60.5-1.10.20.5-0.50.7-1.2-1.1-0.1-0.8-0.10.4-0.5-0.00.10.2-1.3-0.70.2-1.10.2-0.20.2
Number of responses in last shaping day0.40.41.60.5-0.8-0.21.0-0.91.0-0.7-1.3-0.2-0.5-0.4-0.70.80.3-0.3-0.0-0.6-0.50.0-0.10.6-0.60.6