Hub : Genes

Heatr5a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Heatr5a 0.11 0.08 5.4e-09 0.08 0.08 0.09 0.08 1.5e-09 2.5e-09 1.0e-09 2.9e-09
2 NAcc gene expression Heatr5a 0.03 0.03 2.2e-03 0.02 0.02 0.03 0.02 7.7e-04 1.8e-03 6.5e-04 1.7e-03
3 BLA gene expression Heatr5a 0.06 0.05 3.4e-03 0.04 0.01 0.01 0.02 2.8e-03 6.3e-02 1.4e-01 4.5e-02
4 pVTA gene expression Heatr5a 0.08 0.06 2.6e-03 0.08 0.08 0.07 0.08 2.3e-04 3.4e-04 3.7e-04 2.7e-04
5 LHb gene expression Heatr5a 0.17 0.12 2.8e-03 0.13 0.09 0.11 0.11 5.5e-04 3.7e-03 1.7e-03 1.5e-03
6 NAcc intron excision ratio chr6_69362209_69369135 0.03 0.02 1.5e-03 0.03 0.02 0.02 0.02 2.3e-04 1.8e-03 1.7e-03 6.8e-04
7 NAcc intron excision ratio chr6_69369324_69371537 0.03 0.02 1.2e-03 0.03 0.02 0.02 0.03 1.6e-04 6.7e-04 4.5e-03 2.6e-04
8 Adipose mRNA stability Heatr5a 0.05 0.04 1.7e-04 0.03 0.03 0.03 0.02 4.5e-04 4.2e-04 3.7e-04 8.7e-04
9 Adipose intron excision ratio chr6_69410541_69419682 0.04 0.03 4.2e-04 0.03 0.03 0.03 0.03 5.7e-04 2.3e-04 8.0e-04 4.1e-04
10 Liver intron excision ratio chr6_69410541_69419682 0.06 0.05 9.6e-05 0.04 0.04 0.03 0.04 4.3e-05 3.2e-05 1.7e-04 5.6e-05
11 Adipose gene expression Heatr5a 0.04 0.03 4.0e-04 0.02 0.03 0 0.03 8.7e-04 3.3e-04 1.2e-01 6.4e-04
12 Brain gene expression Heatr5a 0.04 0.03 4.1e-03 0.01 0.02 0.03 0.02 1.4e-02 3.8e-03 1.2e-03 1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.01.73.2-1.8-1.7-1.4-1.4-1.5-1.41.41.11.11.0-0.20.9
Area under the delay curve2.83.03.7-1.4-1.4-1.7-1.8-1.7-1.71.71.71.81.81.9-1.8
BMI with tail0.41.32.20.90.91.01.20.91.1-1.1-1.1-1.3-1.3-1.51.4
BMI without tail0.40.84.8-0.2-0.20.20.2-0.00.2-0.2-0.3-0.6-0.8-1.82.2
Body weight1.14.88.8-3.0-2.7-2.4-2.4-2.5-2.22.21.91.71.4-0.82.0
Weight adjusted by age0.60.60.70.80.80.80.80.80.9-0.9-0.8-0.8-0.8-0.60.6
Bone surface2.34.14.8-2.1-2.1-2.2-2.1-2.2-2.12.12.22.22.11.4-0.9
Bone volume2.23.85.2-2.3-2.3-2.1-2.1-2.1-2.12.12.02.01.90.9-0.3
Breakpoint value in progressive ratio session2.72.93.9-1.9-2.0-1.8-2.0-1.9-1.81.81.81.81.60.8-0.1
Number of licking bursts0.10.10.10.30.30.3-0.2-0.00.3-0.3-0.4-0.2-0.3-0.20.1
Context. condit. distance diff. score0.40.51.30.30.40.70.30.30.7-0.7-0.7-0.6-0.8-1.21.0
Locomotion velocity, session 10.20.20.3-0.2-0.3-0.4-0.6-0.6-0.40.40.50.50.40.5-0.4
Locomotion distance, session 11.51.92.91.71.71.51.41.31.5-1.5-1.4-1.4-1.3-0.5-0.0
Locomotion velocity, session 20.40.52.51.00.90.50.10.00.5-0.5-0.3-0.1-0.11.0-1.6
Locomotion distance, session 21.42.03.61.91.81.51.51.41.5-1.5-1.4-1.3-1.20.1-0.7
Locomotion velocity, session 30.60.71.51.21.20.90.60.60.8-0.8-0.9-0.6-0.50.4-1.0
Locomotion distance, session 31.41.52.21.31.41.40.80.91.3-1.3-1.5-1.2-1.3-1.20.8
Stereotopy head waving bouts, day 30.40.52.30.90.80.50.50.60.5-0.5-0.3-0.2-0.00.9-1.5
Stereotopy head waving duration, day 30.30.42.50.50.40.10.20.20.1-0.10.10.20.31.2-1.6
Locomotion velocity, session 76.16.78.32.32.42.72.42.32.6-2.6-2.9-2.8-2.8-2.82.2
Locomotion distance, session 73.64.57.61.51.72.11.51.52.1-2.1-2.3-2.3-2.4-2.82.6
Stereotopy head waving bouts, day 70.70.81.4-0.6-0.7-0.8-0.6-0.7-0.90.90.90.91.01.2-1.2
Stereotopy head waving duration, day 70.50.62.50.0-0.1-0.4-0.1-0.2-0.50.50.60.60.81.4-1.6
Locomotion velocity, session 80.10.10.30.10.2-0.00.20.1-0.30.30.10.20.30.5-0.6
Locomotion distance, session 80.50.71.10.91.01.10.70.70.9-0.9-1.0-0.8-0.9-0.60.2
Degree of sensitization distance0.10.10.4-0.5-0.4-0.2-0.2-0.3-0.10.10.10.0-0.0-0.40.6
Degree of sensitization stereotypy0.91.01.4-1.0-1.0-1.1-0.8-0.9-1.21.21.11.11.10.9-0.6
Conditioned locomotion0.20.31.70.50.40.4-0.1-0.10.3-0.30.00.10.20.9-1.3
Cocaine response after cond. corrected0.30.40.60.50.60.70.50.50.6-0.6-0.7-0.6-0.7-0.80.6
Cocaine response after cond. not corrected0.60.72.00.40.50.70.60.60.6-0.6-0.8-0.8-0.9-1.31.4
Cocaine response before conditioning0.30.31.80.10.20.20.50.50.2-0.2-0.4-0.6-0.6-1.01.3
Saline control response1.11.52.2-1.5-1.4-1.3-1.4-1.4-1.41.41.21.21.10.40.2
Bone: connectivity density1.93.05.3-2.3-2.2-1.9-1.7-2.0-1.81.81.61.51.3-0.41.3
Bone: cortical apparent density1.62.12.91.01.21.41.51.41.4-1.4-1.6-1.6-1.6-1.71.6
Bone: cortical area4.06.07.2-2.4-2.5-2.5-2.6-2.5-2.62.62.72.72.61.9-1.5
Bone: cortical porosity0.91.01.7-0.8-0.8-1.0-0.6-0.6-1.11.11.01.11.21.3-1.3
Bone: cortical porosity1.21.32.3-0.8-0.8-1.1-0.6-0.6-1.21.21.11.21.31.5-1.5
Bone: cortical thickness0.30.50.8-0.9-0.9-0.8-0.8-0.9-0.80.80.70.80.70.20.0
Bone: cortical thickness0.00.10.20.10.20.20.40.30.2-0.2-0.3-0.2-0.2-0.20.0
Bone: cortical tissue density1.72.22.81.11.31.41.51.41.4-1.4-1.6-1.6-1.7-1.71.5
Condit. Reinf. active minus inactive responses3.23.65.8-2.0-2.0-2.1-2.4-2.3-1.91.92.02.01.81.2-0.6
Condit. Reinf. active-inactive response ratio0.40.50.9-0.7-0.8-0.8-0.9-0.9-0.60.60.70.70.60.3-0.2
Condit. Reinf. active responses4.45.47.6-2.3-2.4-2.5-2.8-2.7-2.42.42.52.52.31.7-1.0
Condit. Reinf. inactive responses1.01.21.4-1.0-1.0-1.1-1.1-1.2-1.21.21.21.21.21.0-0.7
Incentive salience index mean4.25.17.5-2.2-2.3-2.4-2.7-2.6-2.32.32.42.42.31.7-1.1
Condit. Reinf. lever presses0.81.11.6-0.9-1.0-1.1-1.3-1.2-1.01.01.11.11.11.0-0.7
Condit. Reinf. active minus inactive responses0.00.00.10.20.30.20.00.00.3-0.3-0.3-0.2-0.2-0.00.0
Condit. Reinf. active-inactive response ratio0.10.10.20.30.40.30.40.30.3-0.3-0.2-0.2-0.10.2-0.4
Condit. Reinf. active responses0.00.10.10.30.30.20.00.00.3-0.3-0.3-0.2-0.20.0-0.1
Condit. Reinf. inactive responses0.10.10.40.20.20.20.00.00.2-0.2-0.3-0.3-0.3-0.50.7
Condit. Reinf. lever presses1.01.32.0-1.2-1.2-1.3-1.3-1.4-1.31.31.11.21.10.8-0.2
Condit. Reinf. lever reinforcers received0.50.71.1-0.7-0.7-0.9-1.0-1.0-0.70.70.70.90.80.8-0.5
Conditioned reinforcement - actives3.03.03.5-1.5-1.5-1.8-1.7-1.8-1.91.91.81.81.91.9-1.5
Conditioned reinforcement - inactives1.21.41.9-1.3-1.3-1.3-1.3-1.4-1.21.21.21.21.10.7-0.2
Conditioned locomotion0.20.20.5-0.3-0.3-0.5-0.4-0.4-0.40.40.40.50.50.7-0.6
Patch foraging indifference point 0 sec3.65.97.1-2.5-2.5-2.6-2.7-2.5-2.62.62.42.62.51.9-1.3
Patch foraging indifference point AUC3.03.44.2-1.7-1.7-2.0-1.6-1.6-1.81.81.82.02.12.0-1.8
Delay disc. indifference point, 0s delay1.41.52.0-1.1-1.1-1.3-1.4-1.4-1.31.31.31.31.31.1-1.0
Delay disc. indifference point, 16s delay1.81.83.2-1.0-1.0-1.3-1.3-1.2-1.31.31.31.41.51.8-1.8
Delay disc. indifference point, 2s delay1.01.11.5-1.0-1.0-1.1-1.2-1.2-1.11.11.01.11.10.8-0.6
Delay disc. indifference point, 24s delay5.04.95.6-1.9-1.9-2.2-2.3-2.3-2.22.22.32.32.32.4-2.2
Delay disc. indifference point, 4s delay0.10.10.70.20.30.10.0-0.00.1-0.1-0.00.10.10.4-0.8
Delay disc. indifference point, 8s delay0.80.91.1-0.9-0.9-1.0-1.1-1.0-1.01.00.91.00.90.8-0.7
Indifference point function ln k0.30.41.00.50.40.70.40.30.6-0.6-0.6-0.7-0.7-0.91.0
Indifference point function log k0.30.41.00.50.40.70.40.30.6-0.6-0.6-0.7-0.7-0.91.0
Patch foraging total patch changes 0 sec4.06.57.8-2.5-2.6-2.7-2.8-2.6-2.72.72.62.72.72.1-1.5
Patch foraging total patch changes 12 sec4.45.67.1-2.5-2.4-2.7-2.4-2.2-2.52.52.52.52.52.1-1.6
Patch foraging total patch changes 18 sec0.91.21.8-1.1-1.1-1.3-0.9-1.0-1.21.21.11.11.11.0-0.7
Patch foraging total patch changes 24 sec1.41.72.2-1.2-1.2-1.5-1.1-1.2-1.41.41.31.31.41.3-1.1
Patch foraging total patch changes 6 sec3.95.87.3-2.5-2.6-2.7-2.7-2.5-2.52.52.42.62.51.9-1.2
Patch foraging time to switch 0 sec14.422.326.84.24.44.84.64.64.7-4.7-5.0-5.1-5.2-5.14.2
Patch foraging water rate 0 sec4.36.98.5-2.3-2.4-2.6-2.6-2.4-2.62.62.82.82.92.9-2.5
Patch foraging water rate 12 sec1.21.92.8-1.7-1.7-1.6-1.5-1.5-1.51.51.31.41.30.50.2
Patch foraging water rate 18 sec2.12.83.6-1.7-1.7-1.9-1.8-1.7-1.71.71.71.81.81.4-1.0
Patch foraging water rate 24 sec1.72.33.1-1.5-1.6-1.6-1.8-1.7-1.61.61.61.71.61.0-0.9
Patch foraging water rate 6 sec5.58.09.3-2.7-2.8-3.0-2.9-2.9-2.92.93.03.03.02.7-2.2
Seeking ratio, delayed vs. immediate footshock0.50.50.91.00.90.80.60.80.9-0.9-0.7-0.6-0.50.1-0.3
Distance traveled before self-admin0.00.00.0-0.1-0.1-0.2-0.2-0.2-0.20.20.20.20.20.2-0.2
Distance traveled after self-admin0.30.30.50.60.70.60.60.60.6-0.6-0.6-0.6-0.5-0.30.0
Extensor digitorum longus weight1.35.19.1-3.0-2.8-2.4-2.3-2.3-2.52.51.91.71.4-0.82.5
Bone: elastic displacement0.60.72.60.30.40.70.40.30.6-0.6-0.8-0.8-1.0-1.41.6
Bone: elastic work0.60.84.7-0.2-0.10.30.1-0.00.2-0.2-0.5-0.6-0.8-1.72.2
Bone: endosteal estimation2.45.29.2-1.6-1.8-2.1-2.1-2.0-2.02.02.42.52.63.0-3.0
Bone: endosteal perimeter4.08.411.6-2.1-2.4-2.7-2.8-2.7-2.82.83.13.23.23.4-3.3
Epididymis fat weight0.30.71.00.80.70.80.80.90.9-0.9-0.8-1.0-1.0-1.00.7
Delta time in closed arm before/after self-admin0.70.70.9-0.9-0.8-0.9-0.7-0.8-1.01.00.80.80.80.5-0.3
Delta time in open arm before/after self-admin0.00.00.2-0.2-0.2-0.3-0.2-0.1-0.10.10.10.10.0-0.30.4
Diff in mean of infusions in LGA sessions0.20.30.70.70.70.50.40.50.5-0.5-0.3-0.3-0.20.4-0.8
Delay discount exponential model param2.02.23.01.21.21.41.51.51.4-1.4-1.5-1.5-1.6-1.71.7
Extinction: sum of active levers before priming1.31.32.6-1.5-1.5-1.2-1.1-1.1-1.11.10.80.80.6-0.81.6
Active lever presses in extinction session 62.22.23.8-1.9-1.8-1.6-1.6-1.6-1.51.51.41.31.1-0.31.1
Bone: final force0.00.00.0-0.0-0.00.1-0.1-0.1-0.10.10.00.10.1-0.0-0.1
Bone: final moment0.00.10.1-0.2-0.2-0.0-0.3-0.2-0.20.20.20.30.30.2-0.3
Food consumed during 24 hour testing period1.31.52.6-1.2-1.3-1.3-1.6-1.4-1.31.31.31.31.20.9-0.5
Glucose1.32.03.2-1.7-1.8-1.5-1.8-1.7-1.41.41.51.31.20.10.5
Heart weight1.11.62.4-1.5-1.5-1.6-1.4-1.4-1.31.31.31.31.20.7-0.2
Delay discount hyperbolic model param1.81.92.61.11.11.31.41.41.3-1.3-1.4-1.5-1.5-1.61.6
Intermittent access intake day 1-15 change0.30.31.1-0.8-0.5-0.6-0.2-0.3-0.70.70.10.20.1-0.61.0
Intermittent access intake escalation0.50.51.5-1.0-0.7-0.7-0.4-0.4-0.90.90.20.30.2-0.61.2
Intermittent access intake escalation 20.60.63.7-0.5-0.3-0.10.10.0-0.30.3-0.4-0.3-0.4-1.41.9
Intermitt. access day 1 inactive lever presses2.42.63.3-1.3-1.3-1.5-1.5-1.6-1.81.81.61.71.71.8-1.5
Intermitt. access day 15 inactive lever presses2.93.14.4-1.5-1.4-1.9-1.6-1.7-1.81.81.81.81.92.1-1.7
Intermitt. access escalation Index0.20.21.1-0.2-0.40.1-0.2-0.20.2-0.2-0.0-0.2-0.3-0.91.0
Intermittent access day 1 total infusions1.21.41.7-1.2-1.2-1.2-1.3-1.3-1.11.11.31.21.21.0-0.6
Intermittent access day 15 total infusions1.21.32.4-1.5-1.3-1.4-1.1-1.2-1.41.41.01.00.90.10.6
Intermittent access terminal intake (last 3 days)1.01.11.8-1.3-1.2-1.2-1.1-1.1-1.31.31.01.00.90.30.3
Intermittent access total infusions0.50.51.0-1.0-0.9-0.8-0.8-0.8-0.80.80.60.70.6-0.10.6
Intermittent access day 1 locomotion1.71.82.2-1.2-1.2-1.4-1.4-1.5-1.41.41.41.41.41.4-1.0
Intermittent access day 15 total locomotion0.60.71.2-1.1-1.0-0.8-0.9-1.0-0.90.90.80.70.6-0.00.6
Intermittent access total locomotion0.40.40.8-0.9-0.8-0.6-0.7-0.8-0.70.70.60.60.5-0.10.6
Intermittent access standard deviation0.70.71.4-1.1-0.8-1.1-0.8-0.7-1.21.20.60.80.80.30.1
Left kidney weight0.10.42.5-0.7-0.5-0.4-0.3-0.2-0.20.2-0.0-0.0-0.2-1.11.6
Right kidney weight0.20.53.2-0.4-0.3-0.10.10.10.1-0.1-0.3-0.4-0.5-1.51.8
Cocaine induced anxiety0.70.81.5-0.6-0.6-0.8-0.8-0.8-0.80.80.90.91.01.2-1.2
Post-drug Anxiety0.50.61.4-0.4-0.5-0.7-0.5-0.6-0.70.70.80.80.91.1-1.2
Baseline Anxiety1.61.72.21.31.31.41.51.41.4-1.4-1.3-1.3-1.3-1.00.7
Tail length0.72.13.8-1.9-1.8-1.5-1.6-1.6-1.61.61.31.31.1-0.11.0
Length with tail2.79.916.4-4.1-3.8-3.4-3.7-3.6-3.43.43.03.02.70.41.1
Length without tail1.94.36.9-2.6-2.5-2.3-2.5-2.4-2.22.21.92.01.80.50.5
Times rat made contact with spout0.91.01.31.01.01.10.70.91.1-1.1-1.1-1.0-1.1-1.10.9
Lifetime Intake0.40.40.8-0.9-0.8-0.7-0.7-0.8-0.70.70.60.60.5-0.00.4
Liver weight, left0.20.30.7-0.8-0.6-0.5-0.8-0.8-0.50.50.40.50.4-0.20.4
Liver weight, right0.10.10.6-0.4-0.3-0.0-0.5-0.4-0.20.2-0.00.1-0.0-0.60.8
Locomotor activity7.211.416.3-4.0-3.9-3.7-3.7-3.8-3.73.73.43.43.21.40.0
Locomotor testing distance4.37.211.8-3.4-3.3-3.0-2.9-2.9-3.03.02.62.62.30.51.0
Locomotor testing rearing2.03.15.7-2.4-2.2-1.7-1.7-1.7-1.91.91.41.21.0-0.92.3
Locomotion in novel chamber2.73.44.01.91.92.02.02.02.0-2.0-2.0-1.9-1.8-1.40.9
Locomotion in novel chamber post-restriction0.30.42.30.40.30.0-0.2-0.10.0-0.00.10.30.41.2-1.5
Fecal boli incidents, locomotor time 10.60.61.2-1.1-1.1-0.8-0.5-0.6-0.80.80.80.50.3-0.71.1
Change in fecal boli incidents, locomotor task0.00.00.3-0.00.00.10.0-0.00.2-0.2-0.2-0.1-0.2-0.30.5
Time >=10cm from walls, locomotor time 10.80.81.3-1.0-1.0-1.0-1.0-1.2-0.90.90.70.90.90.6-0.3
Bouts of movement, locomotor time 12.42.63.4-1.5-1.5-1.8-1.5-1.5-1.71.71.51.71.71.7-1.5
Total resting periods, locomotor time 12.52.83.5-1.5-1.5-1.9-1.6-1.6-1.71.71.61.71.81.8-1.6
Rest time, locomotor task time 13.84.26.5-1.6-1.7-2.1-1.7-1.9-1.91.92.32.02.22.5-2.4
Distance moved, locomotor task time 11.21.42.50.70.81.10.91.11.1-1.1-1.3-1.1-1.2-1.61.6
Vertical activity count, locomotor time 11.11.13.20.60.70.90.60.80.9-0.9-1.2-1.0-1.1-1.61.8
Time >=10cm from walls, locomotor time 21.11.22.1-1.4-1.3-1.2-1.2-1.4-1.31.30.91.00.90.10.3
Bouts of movement, locomotor time 20.30.30.6-0.3-0.4-0.4-0.6-0.4-0.40.40.70.60.60.8-0.7
Total resting periods, locomotor time 20.10.10.30.0-0.1-0.1-0.2-0.0-0.10.10.40.30.30.6-0.5
Rest time, locomotor task time 20.00.00.1-0.1-0.1-0.10.30.0-0.10.10.20.00.10.1-0.1
Distance moved, locomotor task time 20.20.30.6-0.6-0.6-0.6-0.8-0.6-0.50.50.40.60.50.4-0.4
Vertical activity count, locomotor time 20.00.00.10.30.20.2-0.30.00.2-0.2-0.3-0.1-0.10.1-0.3
Light reinforcement 10.10.31.7-0.5-0.3-0.2-0.3-0.2-0.20.2-0.1-0.1-0.2-0.91.3
Light reinforcement 20.30.42.50.20.2-0.1-0.1-0.0-0.20.20.20.30.51.3-1.6
Bone: marrow area2.55.49.3-1.6-1.9-2.1-2.2-2.1-2.02.02.42.52.63.0-3.0
Bone: maximum diameter6.511.914.7-2.7-3.1-3.3-3.5-3.4-3.33.33.73.83.83.8-3.5
Bone: maximum force0.40.60.9-0.7-0.7-0.7-0.8-0.7-0.80.80.80.91.00.8-0.8
Bone: maximum moment0.40.81.1-0.8-0.7-0.7-0.8-0.7-0.90.90.91.01.01.0-1.0
Mean time between licks in bursts0.00.00.0-0.1-0.1-0.10.10.1-0.10.10.20.10.20.2-0.2
Mean num. licks in bursts0.00.10.3-0.1-0.10.00.30.30.1-0.1-0.1-0.1-0.1-0.40.5
Cd content in liver0.30.31.1-0.7-0.7-0.4-0.2-0.2-0.30.30.30.20.1-0.81.0
Co content in liver0.20.20.6-0.5-0.4-0.4-0.7-0.6-0.30.30.20.30.1-0.50.8
Cu content in liver0.81.01.31.01.01.11.00.91.0-1.0-1.1-1.0-1.0-0.90.7
Fe content in liver0.70.91.30.90.90.91.11.10.8-0.8-0.9-1.0-0.9-0.70.6
K content in liver3.43.46.22.52.52.11.92.01.9-1.9-1.8-1.5-1.30.4-1.5
Mg content in liver5.25.48.62.82.92.62.52.62.5-2.5-2.5-2.2-2.0-0.4-0.7
Mn content in liver1.01.28.00.60.6-0.0-0.10.1-0.10.10.20.50.72.1-2.8
Na content in liver2.93.14.71.92.01.92.22.11.7-1.7-1.8-1.8-1.7-1.00.5
Rb content in liver2.22.74.62.12.11.81.71.81.7-1.7-1.8-1.5-1.4-0.1-0.7
Se content in liver5.66.910.52.92.92.83.23.22.8-2.8-2.6-2.7-2.5-1.20.3
Sr content in liver0.10.10.8-0.3-0.2-0.00.10.1-0.00.0-0.1-0.2-0.2-0.70.9
Zn content in liver0.10.10.20.40.40.40.30.40.4-0.4-0.4-0.3-0.3-0.1-0.1
Bone: minimum diameter2.34.35.5-1.9-2.1-2.1-2.0-1.9-2.22.22.32.32.32.0-1.7
Time in familiar zone, hab. session 10.50.51.60.10.20.50.80.70.3-0.3-0.5-0.7-0.6-1.11.3
Time in novel zone, hab. session 10.80.81.3-0.5-0.6-0.9-1.0-1.0-0.70.70.90.90.91.1-1.1
Total zone transitions, hab. session 10.71.01.91.41.41.00.70.90.9-0.9-0.8-0.6-0.50.8-1.4
Total locomotion distance, hab. session 12.53.55.42.32.32.11.92.12.0-2.0-2.0-1.9-1.7-0.5-0.2
Locomotion velocity, hab. session 11.62.34.42.12.01.71.51.71.6-1.6-1.5-1.4-1.20.1-0.8
Time in familiar zone, hab. session 21.71.83.10.80.91.21.51.51.1-1.1-1.3-1.4-1.4-1.71.8
Time in novel zone, hab. session 23.53.54.2-1.4-1.6-1.9-2.1-2.0-1.71.72.02.02.02.0-1.8
Total zone transitions, hab. session 20.91.24.71.41.40.90.60.60.8-0.8-0.6-0.4-0.21.4-2.2
Total locomotion distance, hab. session 20.81.12.81.51.40.90.90.90.9-0.9-0.7-0.6-0.41.1-1.7
Locomotion velocity, hab. session 21.01.33.71.61.51.00.91.01.0-1.0-0.7-0.6-0.41.2-1.9
Novel to familiar place preference ratio1.11.11.3-0.8-0.9-1.0-1.1-1.1-1.01.01.11.11.21.2-1.0
Novelty place preference2.72.73.2-1.4-1.5-1.7-1.7-1.8-1.71.71.71.81.81.7-1.4
Time in novel zone, NPP test2.42.42.8-1.4-1.5-1.6-1.6-1.7-1.61.61.61.71.71.5-1.1
Total zone transitions, NPP test0.30.41.30.90.90.60.40.40.6-0.6-0.4-0.3-0.20.7-1.1
Total locomotion distance, NPP test0.50.71.61.31.20.90.50.50.8-0.8-0.6-0.5-0.40.7-1.2
Locomotion velocity, NPP test0.50.71.61.21.20.90.60.60.8-0.8-0.7-0.6-0.50.5-1.0
Intraocular pressure0.40.51.3-1.1-0.9-0.6-0.8-0.8-0.50.50.50.40.2-0.61.1
Delta distance traveled before/after self-admin0.40.40.70.80.80.80.70.70.7-0.7-0.6-0.6-0.5-0.1-0.3
Delta ambulatory time before/after self-admin0.60.61.11.01.00.90.80.80.9-0.9-0.8-0.8-0.7-0.1-0.3
Parametrial fat weight0.51.06.0-0.3-0.10.20.40.40.3-0.3-0.6-0.7-0.8-1.92.4
Pavlov. Cond. lever latency0.40.51.20.30.30.60.70.50.6-0.6-0.5-0.6-0.7-1.11.0
Pavlov. Cond. magazine entry latency1.11.42.41.51.41.21.21.31.4-1.4-1.2-1.2-1.1-0.1-0.3
Pavlov. Cond. change in total contacts0.20.31.10.10.0-0.2-0.6-0.3-0.10.10.30.40.41.0-1.0
Pavlov. Cond. index score0.30.30.70.80.70.50.30.50.6-0.6-0.5-0.4-0.30.5-0.8
Pavlov. Cond. latency score0.20.20.90.70.60.40.20.30.4-0.4-0.3-0.2-0.10.7-0.9
Pavlov. Cond. lever contacts0.00.10.2-0.1-0.1-0.2-0.3-0.2-0.20.20.10.20.20.4-0.3
Pavlov. Cond. magazine entry number0.91.12.1-1.5-1.3-1.0-1.0-1.2-1.21.20.90.90.8-0.30.8
Pavlov. Cond. intertrial magazine entries0.30.31.6-0.5-0.4-0.3-0.7-0.8-0.30.30.10.1-0.1-0.91.3
Pavlov. Cond. lever-magazine prob. diff.0.30.40.90.90.90.60.40.60.7-0.7-0.6-0.5-0.40.4-0.7
Pavlov. Cond. response bias0.40.51.01.00.90.60.60.70.7-0.7-0.6-0.5-0.40.4-0.7
Pavlov. Cond. lever latency2.53.34.21.91.92.11.92.01.9-1.9-1.9-1.9-1.9-1.50.8
Pavlov. Cond. magazine entry latency0.00.00.10.30.20.10.10.20.3-0.3-0.2-0.2-0.20.10.0
Pavlov. Cond. change in total contacts2.83.85.0-2.2-2.1-2.2-2.1-2.2-2.12.12.02.02.01.3-0.4
Pavlov. Cond. index score1.72.22.9-1.6-1.6-1.7-1.7-1.7-1.51.51.51.51.51.1-0.4
Pavlov. Cond. latency score1.72.12.6-1.5-1.5-1.6-1.6-1.6-1.51.51.41.51.51.2-0.5
Pavlov. Cond. lever contacts1.42.02.7-1.6-1.5-1.7-1.5-1.6-1.51.51.41.41.41.0-0.4
Pavlov. Cond. magazine entry number1.01.21.61.01.11.21.31.31.0-1.0-1.0-1.2-1.1-1.10.7
Pavlov. Cond. intertrial magazine entries0.20.20.60.60.60.80.20.30.5-0.5-0.4-0.3-0.4-0.1-0.2
Pavlov. Cond. lever-magazine prob. diff.1.82.23.0-1.6-1.6-1.7-1.7-1.7-1.51.51.51.51.51.1-0.4
Pavlov. Cond. response bias1.01.42.0-1.3-1.2-1.4-1.3-1.3-1.21.21.21.21.20.9-0.3
Time in closed arm before self-admin2.12.43.51.91.71.71.61.61.8-1.8-1.5-1.5-1.5-0.80.3
Time in closed arm after self-admin0.70.71.31.11.11.01.00.90.9-0.9-0.9-0.8-0.7-0.1-0.4
Time in open arm before self-admin0.60.61.5-0.5-0.5-0.6-0.7-0.7-0.80.80.90.80.81.1-1.2
Time in open arm after self-admin0.10.10.90.10.0-0.3-0.2-0.1-0.10.10.20.20.30.7-1.0
Bone: periosteal estimation4.39.011.4-2.4-2.6-2.9-2.9-2.8-2.82.83.23.33.43.4-3.2
Bone: periosteal perimeter3.76.27.7-2.0-2.2-2.4-2.5-2.4-2.52.52.72.82.82.6-2.4
Bone: post-yield work0.81.11.9-0.9-0.8-1.1-0.5-0.6-1.11.11.01.11.21.4-1.3
Progressive ratio test 1 active lever presses1.11.21.5-1.1-1.1-1.2-1.1-1.2-1.21.21.21.11.10.8-0.4
Progressive ratio test 1 breakpoint1.21.31.4-1.0-1.1-1.2-1.1-1.2-1.21.21.21.21.21.1-0.8
Progressive ratio test 1 inactive lever presses2.93.24.1-1.7-1.8-1.9-1.9-2.0-1.71.71.91.91.91.6-1.1
Progressive ratio test 2 active lever presses0.10.10.10.40.40.30.40.30.4-0.4-0.3-0.3-0.3-0.10.0
Progressive ratio test 2 breakpoint0.20.20.30.50.50.40.50.50.5-0.5-0.5-0.4-0.4-0.20.1
Progressive ratio test 2 inactive lever presses1.11.31.7-1.1-1.1-1.2-1.2-1.3-1.31.31.21.21.21.0-0.6
Incentive Sensitization - Responses4.74.75.72.32.32.32.42.32.3-2.3-2.4-2.2-2.2-1.60.9
Incentive Sensitization - Breakpoint4.24.35.22.22.22.22.32.22.2-2.2-2.3-2.1-2.1-1.51.0
Sum of active levers in priming session hrs 5-60.80.71.1-1.1-1.0-0.9-1.0-1.0-1.01.00.90.80.70.00.3
Progressive ratio0.40.51.40.90.80.60.50.60.7-0.7-0.6-0.4-0.20.7-1.2
Food seeking constrained by brief footshock0.10.20.7-0.0-0.0-0.2-0.6-0.4-0.10.10.30.40.40.7-0.8
Seeking ratio, punishment vs. effort0.20.30.5-0.7-0.6-0.5-0.6-0.7-0.60.60.60.40.3-0.20.6
Retroperitoneal fat weight1.23.89.70.91.11.41.81.61.6-1.6-1.9-2.0-2.2-3.13.1
Reaction time number correct0.30.41.00.30.30.60.50.50.3-0.3-0.6-0.6-0.6-1.01.0
Reaction time mean minus median4.25.69.63.12.92.52.62.42.8-2.8-2.3-2.2-1.9-0.0-1.2
Reaction time mean minus median AUC3.24.16.92.62.52.22.32.22.3-2.3-2.0-1.9-1.6-0.1-1.0
Reaction time num false alarms0.40.60.9-0.5-0.6-0.7-0.8-0.8-0.70.70.70.80.80.9-0.9
Reaction time num false alarms AUC0.30.51.1-0.5-0.5-0.7-0.6-0.6-0.60.60.60.70.70.9-1.0
Reaction time trials correct on left0.30.41.00.30.30.60.50.50.3-0.3-0.6-0.6-0.6-1.01.0
Reaction time trials on left0.20.30.80.30.30.60.50.50.3-0.3-0.5-0.6-0.6-0.90.9
Reaction time mean2.02.74.01.91.81.72.01.91.8-1.8-1.6-1.7-1.6-0.90.3
Reaction time mean AUC2.43.24.52.01.91.82.12.02.0-2.0-1.8-1.9-1.8-1.10.6
Median of all reaction times1.31.82.71.31.21.31.61.51.4-1.4-1.3-1.5-1.4-1.20.8
Reaction time omissions1.41.93.82.01.81.21.41.21.4-1.4-1.1-1.0-0.70.9-1.7
Reaction time false alarm rate0.81.11.8-0.8-0.8-1.1-1.0-1.0-0.90.91.01.11.11.3-1.3
Reaction time premature initiation rate1.01.41.7-1.3-1.2-1.1-1.2-1.3-1.31.31.21.31.31.0-0.5
Reaction time premature initiations0.40.61.0-1.0-0.9-0.7-0.8-0.9-1.01.00.70.80.80.40.1
Std. dev. reaction times2.94.17.22.72.52.22.32.12.3-2.3-1.9-1.9-1.7-0.1-1.0
Reaction time trials completed0.20.30.80.30.30.60.50.50.3-0.3-0.5-0.6-0.6-0.90.9
Reaction time trials AUC0.20.31.10.20.20.50.40.50.2-0.2-0.5-0.5-0.5-1.01.0
Run reversals in cocaine runway, females0.40.42.00.60.50.30.40.30.3-0.30.10.00.21.1-1.4
Run reversals in cocaine runway, males0.00.00.1-0.00.00.1-0.00.00.1-0.1-0.2-0.1-0.2-0.30.3
Latency to leave start box in cocaine runway0.20.30.40.60.60.60.30.60.6-0.6-0.6-0.5-0.5-0.30.1
Latency to leave start box in cocaine runway, F0.40.40.70.80.80.70.50.70.8-0.8-0.7-0.6-0.6-0.3-0.0
Latency to leave start box in cocaine runway, M0.00.00.0-0.0-0.0-0.1-0.1-0.1-0.10.10.00.10.10.1-0.1
Std. dev. time between licks in bursts0.50.71.30.80.80.81.11.10.8-0.8-0.7-0.9-0.8-0.50.4
Total sessions with >9 infusions1.82.03.0-1.6-1.6-1.5-1.5-1.7-1.41.41.51.41.40.8-0.3
Short access day 1 total inactive lever presses3.84.36.9-2.6-2.6-2.3-2.4-2.4-2.12.12.11.91.70.20.9
Short access day 10 total inactive lever presses1.51.62.8-1.0-0.9-1.3-1.1-1.1-1.31.31.21.31.41.7-1.4
Short access day 1 total infusions1.92.03.1-1.7-1.8-1.5-1.7-1.7-1.51.51.51.31.20.20.4
Short access day 10 total infusions0.60.61.0-0.8-0.7-1.0-0.8-0.8-0.90.90.80.80.80.7-0.4
Short access total infusions0.20.20.4-0.6-0.6-0.4-0.6-0.6-0.40.40.50.40.3-0.20.4
Short access day 1 locomotion0.70.71.3-1.0-1.1-0.9-1.1-1.2-0.80.80.90.80.70.10.2
Short access day 10 total locomotion0.30.30.8-0.8-0.5-0.8-0.5-0.5-0.90.90.40.50.50.20.2
Short access total locomotion1.01.01.4-1.2-1.1-1.1-1.1-1.2-1.21.21.01.00.90.40.0
One hour access (0.3 mA shock)2.22.64.0-2.0-1.8-1.8-1.6-1.7-2.02.01.51.51.40.40.4
Compulsive drug intake0.40.41.2-0.1-0.5-0.2-0.6-0.8-0.20.20.70.60.61.0-1.1
One hour access (shock baseline)0.40.51.3-1.0-0.6-0.8-0.3-0.4-1.01.00.20.30.2-0.61.1
Social response proportion0.60.61.4-0.8-0.6-0.7-1.2-1.0-0.70.70.70.80.70.5-0.5
Social responses1.01.31.9-1.2-1.1-1.3-1.4-1.2-1.11.11.11.21.10.9-0.7
Social time1.31.83.0-1.7-1.6-1.5-1.4-1.4-1.51.51.31.31.10.20.3
Soleus weight1.44.05.5-2.1-2.0-2.1-1.9-2.0-2.32.32.02.12.21.7-1.0
Bone: stiffness0.30.52.80.0-0.1-0.3-0.3-0.2-0.30.30.50.70.81.2-1.7
Tibialis anterior weight1.75.810.3-3.2-3.0-2.5-2.4-2.6-2.72.72.12.01.7-0.62.2
Time to tail flick, vehicle, before self-admin0.10.10.40.10.0-0.0-0.1-0.0-0.00.00.10.20.30.5-0.6
Time to tail flick, vehicle, after self-admin0.50.61.3-0.3-0.4-0.6-0.6-0.6-0.70.70.70.70.81.1-1.1
Time to tail flick, test, before self-admin0.10.10.40.20.10.20.20.20.1-0.1-0.3-0.3-0.3-0.50.6
Time to tail flick, test, after self-admin0.91.01.6-1.3-1.2-1.0-1.0-1.1-1.11.11.11.00.90.20.2
Delta time to tail flick, vehicle, before/after SA0.30.30.6-0.4-0.4-0.5-0.4-0.5-0.50.50.50.50.50.8-0.7
Delta time to tail flick, test, before/after SA0.00.00.1-0.2-0.1-0.1-0.0-0.1-0.10.10.10.10.10.2-0.3
Tibia length2.05.76.9-2.5-2.6-2.4-2.6-2.6-2.52.52.62.52.42.0-1.4
Ambulatory time before self-admin0.00.00.0-0.1-0.1-0.1-0.2-0.1-0.20.20.10.10.10.1-0.1
Ambulatory time after self-admin0.60.70.80.90.80.90.80.80.9-0.9-0.8-0.9-0.9-0.70.4
Bone: tissue strength0.60.60.80.80.90.80.50.50.8-0.8-0.9-0.8-0.8-0.70.6
Total heroin consumption1.82.13.1-1.7-1.8-1.6-1.6-1.6-1.51.51.61.51.40.6-0.1
Bone: trabecular number0.81.32.8-1.6-1.4-1.0-0.9-1.1-1.21.20.70.70.5-0.91.7
Bone: trabecular spacing4.86.28.52.82.92.92.52.62.7-2.7-2.7-2.6-2.5-1.40.6
Bone: trabecular thickness1.11.32.2-1.5-1.5-1.3-1.3-1.3-1.21.21.11.11.00.20.3
Bone: trabecular tissue density0.70.91.81.31.21.01.11.20.7-0.7-0.7-0.6-0.40.8-1.3
Water consumed over 24 hours0.20.30.8-0.6-0.6-0.4-0.6-0.4-0.40.40.20.30.1-0.60.9
Number of responses in last shaping day0.20.20.4-0.4-0.0-0.6-0.1-0.1-0.60.60.10.30.40.5-0.5