Hub : Genes

Haus2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	alternative polyA	NM_001402746.1	0.04	0.02	4.7e-03	0.01	0.01	0.01	0.01	2.2e-02	2.1e-02	2.8e-02	2.1e-02
2	pVTA	alternative polyA	XM_063282988.1	0.03	0.02	5.2e-03	0.02	0.01	0.01	0.01	1.8e-02	2.4e-02	3.1e-02	2.0e-02
3	PL	alternative TSS	XM_063282988.1	0.05	0.02	4.3e-06	0.04	0.04	0.04	0.03	2.2e-05	6.7e-05	9.7e-05	2.0e-04
4	RMTg	gene expression	Haus2	0.17	0.09	1.3e-03	0.05	0.04	0.01	0.04	2.3e-02	2.8e-02	2.0e-01	4.1e-02
5	PL	alternative TSS	NM_001402746.1	0.06	0.03	2.2e-06	0.06	0.05	0.05	0.05	5.2e-07	3.3e-06	6.1e-06	2.7e-06
6	Brain	mRNA stability	Haus2	0.17	0.07	3.9e-16	0.18	0.18	0.17	0.18	5.4e-17	8.8e-17	4.1e-16	7.1e-17
7	IC	alternative TSS	NM_001402746.1	0.11	0.07	1.4e-03	0.01	0.01	0.03	0.01	1.7e-01	1.1e-01	1.9e-02	1.1e-01
8	BLA	gene expression	Haus2	0.14	0.06	2.2e-06	0.08	0.09	0.09	0.07	7.6e-05	2.2e-05	2.8e-05	1.2e-04
9	Brain	gene expression	Haus2	0.06	0.04	8.8e-05	0.03	0.04	0.04	0.04	2.0e-03	9.4e-05	8.6e-05	6.8e-05
10	IL	gene expression	Haus2	0.2	0.11	2.7e-03	0.12	0.11	0.09	0.12	9.8e-04	1.1e-03	3.7e-03	6.9e-04
11	IC	gene expression	Haus2	0.24	0.1	2.1e-06	0.17	0.13	0.14	0.16	1.1e-07	4.7e-06	1.5e-06	2.5e-07
12	NAcc	alternative TSS	NM_001402746.1	0.03	0.02	8.3e-04	0.03	0.01	0.02	0.02	2.3e-05	5.4e-03	1.2e-04	2.9e-04
13	pVTA	gene expression	Haus2	0.19	0.07	2.5e-13	0.16	0.17	0.17	0.17	4.5e-13	8.1e-14	2.6e-13	8.3e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bone: apparent density	1.4	2.5	3.6	-1.7	1.5	1.7	1.7	-1.6	1.8	-1.6	-1.6	1.5	1.9	-1.3	-1.0	-1.4
Area under the delay curve	2.2	2.5	9.2	-2.1	1.2	1.6	1.6	-1.7	1.3	-3.0	-0.3	2.4	1.5	-0.3	0.1	-0.5
BMI with tail	3.3	11.5	19.0	-4.4	3.7	3.7	3.6	-3.5	3.7	-3.2	-3.2	3.4	3.4	-3.3	-2.3	-2.4
BMI without tail	5.7	17.3	25.1	-5.0	4.5	4.6	4.5	-4.1	4.6	-3.2	-4.3	4.1	3.9	-4.1	-3.2	-3.4
Body weight	3.6	15.8	27.1	-5.2	4.2	4.4	4.4	-4.0	4.3	-3.5	-3.7	4.2	3.9	-3.8	-2.5	-2.9
Weight adjusted by age	0.1	0.2	0.6	-0.8	0.5	0.1	0.1	-0.0	0.1	-0.5	0.1	0.5	0.0	0.1	0.7	0.5
Bone surface	1.2	2.1	3.2	-1.3	1.2	1.4	1.4	-1.6	1.4	-1.3	-1.8	0.8	1.6	-1.8	-1.5	-1.6
Bone volume	1.0	1.8	2.6	-1.3	1.3	1.2	1.3	-1.6	1.3	-1.2	-1.6	0.6	1.6	-1.6	-1.2	-1.4
Breakpoint value in progressive ratio session	0.3	0.4	1.0	0.1	-0.1	0.3	0.3	-0.9	0.1	0.7	-0.7	-0.3	0.4	-1.0	-0.9	-0.9
Number of licking bursts	0.4	0.7	1.8	-0.1	0.4	0.7	0.7	-1.1	0.5	0.1	-1.0	0.0	0.7	-1.1	-1.3	-1.2
Context. condit. distance diff. score	1.4	1.7	3.9	-1.2	2.0	1.2	1.3	-1.0	1.5	0.1	-1.9	0.4	0.8	-1.6	-1.4	-1.2
Locomotion velocity, session 1	2.4	2.6	6.9	1.5	-1.6	-1.3	-1.5	1.5	-1.5	-0.2	2.1	-0.7	-1.5	2.6	1.8	1.8
Locomotion distance, session 1	1.0	1.3	4.2	0.9	-0.8	-0.8	-0.9	1.3	-0.9	0.1	1.4	-0.3	-1.1	2.1	1.4	1.3
Locomotion velocity, session 2	1.3	1.5	4.3	-1.6	1.4	1.4	1.4	-1.2	1.2	-2.1	-0.4	1.7	0.8	0.3	-0.0	-0.2
Locomotion distance, session 2	0.0	0.1	0.4	0.2	0.0	0.3	0.1	0.3	0.1	0.1	0.0	0.3	-0.2	0.7	-0.0	-0.0
Locomotion velocity, session 3	0.2	0.3	2.0	-0.4	0.6	0.3	0.2	-0.7	0.1	-1.4	0.2	0.3	0.2	0.4	-0.0	0.4
Locomotion distance, session 3	0.3	0.3	1.1	0.1	1.1	0.0	-0.0	-0.5	-0.1	-0.4	-0.6	-1.0	-0.2	-0.3	-1.0	-0.1
Stereotopy head waving bouts, day 3	0.8	1.0	3.7	-1.7	1.2	0.9	0.7	-0.7	0.7	-1.9	-0.0	1.2	0.7	-0.2	0.6	0.5
Stereotopy head waving duration, day 3	2.0	2.4	7.0	-2.4	1.4	1.6	1.5	-1.5	1.4	-2.7	-0.2	2.3	1.5	-0.4	0.5	-0.0
Locomotion velocity, session 7	0.2	0.2	1.3	-0.2	1.1	-0.1	-0.1	0.2	-0.1	-0.1	-0.2	-0.7	-0.5	0.4	0.2	0.7
Locomotion distance, session 7	0.2	0.3	1.2	0.3	0.5	0.0	-0.1	0.4	-0.0	1.1	-0.6	-0.6	-0.6	-0.3	-0.7	-0.2
Stereotopy head waving bouts, day 7	0.3	0.3	0.5	0.4	-0.7	-0.7	-0.6	0.3	-0.6	-0.6	0.7	-0.6	-0.2	0.4	0.4	0.7
Stereotopy head waving duration, day 7	0.3	0.4	0.6	0.4	-0.8	-0.8	-0.7	0.2	-0.8	-0.5	0.8	-0.8	-0.3	0.3	0.6	0.8
Locomotion velocity, session 8	1.6	2.0	4.8	-2.0	2.2	1.6	1.5	-1.2	1.4	-2.1	-0.9	1.5	1.0	-0.3	-0.1	-0.2
Locomotion distance, session 8	0.6	0.9	3.1	-0.9	1.8	1.1	1.0	-0.5	1.3	-0.0	-1.4	0.5	0.4	-0.6	-1.0	-0.7
Degree of sensitization distance	0.7	0.7	3.1	0.9	-1.2	-0.7	-0.7	1.1	-0.6	1.8	0.4	-0.4	-0.6	0.0	0.5	0.1
Degree of sensitization stereotypy	0.8	0.9	2.4	1.1	-1.0	-1.3	-1.2	0.9	-1.1	0.6	0.7	-1.6	-0.8	0.3	0.3	0.7
Conditioned locomotion	2.0	2.3	3.0	-1.7	1.5	1.7	1.7	-1.4	1.7	-1.1	-1.5	1.5	1.6	-1.4	-1.1	-1.3
Cocaine response after cond. corrected	0.4	0.5	1.4	0.1	0.3	0.6	0.6	-1.1	0.3	-0.5	-0.7	0.2	0.8	-0.6	-1.2	-1.1
Cocaine response after cond. not corrected	0.4	0.4	1.1	0.1	0.2	0.7	0.7	-1.0	0.3	-0.7	-0.5	0.6	0.8	-0.3	-0.9	-1.0
Cocaine response before conditioning	0.6	0.8	2.4	0.3	-0.4	-0.6	-0.6	1.0	-0.6	-0.1	1.1	0.1	-0.9	1.5	1.3	1.2
Saline control response	0.1	0.2	0.7	-0.8	0.3	0.1	0.1	0.3	0.1	-0.3	0.3	0.4	0.0	0.0	0.8	0.8
Bone: connectivity density	0.3	0.5	1.2	-0.8	0.1	0.7	0.7	-0.5	0.8	-1.1	-0.4	0.9	0.8	-0.5	-0.1	-0.5
Bone: cortical apparent density	0.9	1.3	4.3	1.7	-1.4	-1.0	-1.1	0.6	-1.0	2.1	0.0	-1.7	-0.5	-0.7	-0.5	-0.3
Bone: cortical area	1.0	1.5	2.8	-1.7	1.4	1.2	1.2	-1.5	1.1	-1.5	-1.1	1.0	1.4	-1.1	-0.6	-0.8
Bone: cortical porosity	0.5	0.6	1.6	-0.6	0.9	0.7	0.8	-0.5	0.8	-1.3	-0.0	1.2	0.4	0.9	0.2	-0.2
Bone: cortical porosity	0.6	0.6	2.0	-0.9	1.1	0.7	0.7	-0.5	0.8	-1.4	-0.0	1.1	0.5	0.8	0.4	0.1
Bone: cortical thickness	0.8	1.4	2.9	-1.7	1.5	1.2	1.2	-1.3	1.1	-1.4	-0.9	1.2	1.3	-0.6	-0.3	-0.5
Bone: cortical thickness	1.4	1.6	3.3	-0.6	0.6	1.1	1.1	-1.7	1.1	-0.4	-1.3	0.7	1.8	-1.5	-1.6	-1.8
Bone: cortical tissue density	0.9	1.2	3.9	1.6	-1.3	-1.0	-1.0	0.6	-0.9	2.0	0.1	-1.6	-0.4	-0.7	-0.5	-0.3
Condit. Reinf. active minus inactive responses	3.1	3.5	5.6	1.9	-2.1	-2.1	-2.1	2.0	-2.1	1.8	1.4	-2.4	-2.1	0.9	1.2	1.5
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.2	0.4	-0.6	-0.8	-0.7	0.5	-0.8	0.2	0.3	-1.1	-0.8	-0.1	0.5	0.7
Condit. Reinf. active responses	5.7	7.0	10.2	2.9	-3.0	-3.0	-2.9	3.0	-2.9	2.9	2.0	-3.2	-2.9	1.4	1.5	2.0
Condit. Reinf. inactive responses	3.6	4.4	7.8	2.6	-2.2	-2.3	-2.2	2.4	-2.2	2.8	1.4	-2.5	-2.2	1.3	0.8	1.3
Incentive salience index mean	4.8	5.9	8.3	2.6	-2.9	-2.6	-2.6	2.7	-2.6	2.5	2.0	-2.6	-2.7	1.5	1.6	1.9
Condit. Reinf. lever presses	3.3	4.6	7.1	2.2	-2.7	-2.1	-2.2	2.6	-2.2	2.3	1.9	-1.9	-2.5	1.6	1.6	1.7
Condit. Reinf. active minus inactive responses	0.2	0.3	1.3	-0.0	-0.4	0.2	0.3	0.2	0.2	0.8	-0.6	0.2	0.4	-1.1	-0.8	-0.7
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.3	0.0	-0.2	0.3	0.3	0.1	0.2	0.7	-0.7	0.0	0.3	-1.1	-0.9	-0.8
Condit. Reinf. active responses	0.2	0.3	1.2	-0.1	-0.4	0.1	0.1	0.2	0.0	1.0	-0.5	-0.0	0.3	-1.1	-0.6	-0.5
Condit. Reinf. inactive responses	0.1	0.2	0.5	0.1	-0.7	-0.5	-0.5	0.3	-0.5	0.6	0.4	-0.3	-0.1	-0.2	0.5	0.4
Condit. Reinf. lever presses	0.2	0.2	1.1	-0.1	-1.0	-0.4	-0.4	0.4	-0.6	0.3	0.6	-0.0	0.1	-0.3	0.6	0.5
Condit. Reinf. lever reinforcers received	0.2	0.3	1.4	0.2	-0.9	-0.3	-0.2	0.5	-0.3	1.2	-0.1	-0.2	-0.0	-0.7	-0.2	-0.2
Conditioned reinforcement - actives	0.1	0.1	0.2	0.3	-0.4	-0.3	-0.2	0.0	-0.1	-0.5	0.5	-0.1	0.0	0.5	0.4	0.1
Conditioned reinforcement - inactives	0.2	0.3	1.1	-0.2	0.7	0.3	0.4	-0.5	0.6	-0.1	-0.8	-0.2	0.3	-0.5	-1.1	-0.5
Conditioned locomotion	1.1	1.4	3.6	0.3	-0.8	-1.0	-0.9	1.2	-0.8	-0.9	1.8	0.1	-1.0	1.9	1.6	1.7
Patch foraging indifference point 0 sec	0.5	0.9	4.4	-0.9	-0.2	-0.3	-0.2	0.4	-0.4	-0.7	1.4	0.3	-0.1	0.8	2.1	1.8
Patch foraging indifference point AUC	1.9	2.8	4.0	2.0	-1.7	-1.9	-1.9	1.8	-1.9	1.3	1.6	-1.8	-1.6	1.6	1.1	1.4
Delay disc. indifference point, 0s delay	0.6	0.7	1.8	-0.1	-0.7	-0.3	-0.5	0.4	-0.6	-1.2	1.3	0.4	-0.4	0.8	1.3	1.2
Delay disc. indifference point, 16s delay	0.7	0.8	4.6	-1.0	0.5	0.5	0.7	-1.0	0.5	-2.1	0.3	1.2	0.9	0.4	0.3	0.0
Delay disc. indifference point, 2s delay	0.2	0.2	0.5	-0.6	0.7	0.6	0.6	-0.4	0.4	-0.1	-0.7	0.4	0.1	-0.6	-0.3	-0.3
Delay disc. indifference point, 24s delay	0.6	0.7	1.9	0.6	-1.1	-0.7	-0.6	0.7	-0.8	-0.5	1.4	0.1	-0.6	1.3	1.0	0.8
Delay disc. indifference point, 4s delay	1.3	1.4	4.8	-1.5	1.0	1.3	1.2	-1.0	1.0	-2.2	-0.3	1.8	0.9	-0.1	0.1	-0.3
Delay disc. indifference point, 8s delay	3.3	3.9	13.0	-2.7	1.6	2.1	1.9	-2.3	1.6	-3.6	-0.6	2.6	2.0	-0.8	-0.0	-0.6
Indifference point function ln k	3.2	5.7	7.5	-2.7	2.7	2.7	2.7	-2.6	2.5	-1.8	-2.4	2.3	2.4	-2.1	-1.8	-2.0
Indifference point function log k	3.2	5.7	7.5	-2.7	2.7	2.7	2.7	-2.6	2.5	-1.8	-2.4	2.3	2.4	-2.1	-1.8	-2.0
Patch foraging total patch changes 0 sec	0.4	0.7	3.5	-0.8	-0.2	-0.3	-0.3	0.3	-0.4	-0.6	1.2	0.1	-0.1	0.7	1.9	1.7
Patch foraging total patch changes 12 sec	2.1	2.8	4.3	1.2	-1.3	-1.7	-1.7	1.8	-1.6	1.5	1.8	-1.7	-1.5	1.5	2.1	2.1
Patch foraging total patch changes 18 sec	1.5	2.3	3.0	1.4	-1.3	-1.7	-1.6	1.6	-1.5	1.5	1.4	-1.7	-1.4	1.5	1.4	1.6
Patch foraging total patch changes 24 sec	0.3	0.6	1.9	-1.2	0.3	0.7	0.7	-0.5	0.7	-1.0	0.1	1.4	1.0	-0.1	0.4	-0.0
Patch foraging total patch changes 6 sec	1.4	2.1	3.4	1.0	-1.2	-1.4	-1.4	1.4	-1.7	1.0	1.5	-1.6	-1.6	1.2	1.7	1.8
Patch foraging time to switch 0 sec	1.0	2.0	3.9	1.4	-2.0	-1.6	-1.5	1.4	-1.4	1.1	1.5	-1.3	-1.4	1.1	1.3	1.3
Patch foraging water rate 0 sec	0.6	1.3	3.0	-0.9	1.3	1.1	1.0	-1.2	0.9	0.1	-1.5	0.2	1.1	-1.7	-1.3	-1.1
Patch foraging water rate 12 sec	1.6	3.3	7.7	-0.8	1.5	1.7	1.5	-2.1	1.6	-0.5	-2.3	0.6	1.7	-2.4	-2.8	-2.4
Patch foraging water rate 18 sec	2.1	3.3	5.3	-1.6	1.9	2.0	1.9	-2.3	1.8	-1.3	-1.9	1.4	2.0	-1.7	-1.8	-1.9
Patch foraging water rate 24 sec	1.2	1.6	4.1	-0.3	1.1	0.9	0.8	-1.4	0.8	0.5	-1.9	-0.6	1.2	-2.0	-2.0	-1.6
Patch foraging water rate 6 sec	0.8	1.2	4.3	0.6	0.3	0.5	0.4	-0.8	0.3	1.2	-1.4	-0.7	0.6	-1.6	-2.1	-1.6
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	2.0	-0.2	0.7	0.8	0.8	-0.4	0.6	1.4	-1.3	-0.1	0.5	-1.3	-1.1	-1.1
Distance traveled before self-admin	1.0	1.4	1.9	-1.2	1.0	1.4	1.4	-1.3	1.4	-0.7	-1.2	1.3	1.1	-1.2	-0.9	-1.1
Distance traveled after self-admin	0.3	0.4	1.2	-0.1	0.1	0.5	0.5	-0.7	0.6	0.1	-0.8	0.1	0.5	-1.1	-0.9	-1.0
Extensor digitorum longus weight	0.3	1.0	2.3	-1.3	1.5	0.9	1.0	-1.2	1.0	-1.4	-0.9	0.6	1.1	-0.8	-0.5	-0.5
Bone: elastic displacement	0.4	0.5	1.2	0.3	-0.3	-0.7	-0.7	0.6	-0.6	-0.3	0.9	-0.6	-0.5	0.9	1.0	1.1
Bone: elastic work	0.1	0.2	0.5	-0.3	0.0	-0.4	-0.3	-0.0	-0.3	-0.6	0.3	-0.5	0.0	0.0	0.7	0.7
Bone: endosteal estimation	0.4	0.8	1.5	-0.4	0.8	0.8	0.8	-1.0	0.7	-0.5	-1.2	0.2	0.8	-1.1	-1.2	-1.2
Bone: endosteal perimeter	0.1	0.1	0.6	-0.1	0.3	0.1	0.1	-0.3	0.1	-0.8	-0.5	-0.2	0.1	-0.5	-0.5	-0.4
Epididymis fat weight	0.4	1.4	3.0	-1.6	1.6	1.3	1.3	-1.1	1.3	-1.7	-0.7	1.3	0.9	-0.2	-0.2	-0.4
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	0.3	0.4	0.0	0.0	0.3	-0.3	0.5	-0.5	-0.6	-0.7	-0.2	-0.4	-0.1
Delta time in open arm before/after self-admin	2.8	2.8	5.4	-1.1	1.5	1.6	1.6	-1.6	1.9	-0.0	-2.3	0.6	1.7	-2.0	-2.1	-2.0
Diff in mean of infusions in LGA sessions	0.9	1.1	1.4	1.0	-1.2	-1.1	-1.1	1.1	-1.0	1.1	0.9	-1.1	-1.2	0.7	0.8	0.9
Delay discount exponential model param	2.0	2.2	7.6	1.9	-1.2	-1.5	-1.5	1.5	-1.3	2.8	0.3	-2.3	-1.4	0.3	-0.0	0.5
Extinction: sum of active levers before priming	0.4	0.5	0.8	0.7	-0.7	-0.7	-0.7	0.4	-0.7	0.0	0.9	-0.6	-0.7	0.9	0.7	0.6
Active lever presses in extinction session 6	0.2	0.2	1.0	0.0	-0.0	0.0	0.0	0.2	-0.3	-0.1	0.5	0.3	-0.6	1.0	0.8	0.5
Bone: final force	0.1	0.2	0.8	-0.4	0.8	0.2	0.2	-0.2	0.1	0.1	-0.8	-0.5	0.3	-0.9	-0.5	-0.2
Bone: final moment	0.1	0.2	0.7	-0.3	0.8	0.1	0.1	-0.2	0.1	0.2	-0.7	-0.6	0.3	-0.8	-0.4	-0.1
Food consumed during 24 hour testing period	0.5	0.7	1.4	-0.3	0.9	0.8	0.8	-0.7	0.8	-0.2	-1.0	0.7	0.9	-0.7	-1.2	-1.2
Glucose	1.0	1.6	4.7	-1.2	2.2	1.2	1.2	-1.3	1.2	-0.5	-1.8	0.2	0.6	-1.3	-1.3	-0.9
Heart weight	3.4	5.3	8.2	-2.9	2.4	2.6	2.6	-2.1	2.6	-1.6	-2.4	2.4	2.1	-2.3	-1.8	-1.8
Delay discount hyperbolic model param	1.8	2.0	6.2	1.9	-1.2	-1.5	-1.5	1.4	-1.2	2.5	0.4	-2.1	-1.3	0.3	0.0	0.5
Intermittent access intake day 1-15 change	1.8	3.7	10.9	-1.1	1.7	1.7	1.8	-1.8	1.8	-0.7	-2.3	0.9	2.2	-2.1	-3.3	-2.3
Intermittent access intake escalation	2.0	4.2	10.5	-1.3	1.7	1.9	2.0	-2.0	2.0	-0.9	-2.4	1.1	2.3	-2.3	-3.2	-2.4
Intermittent access intake escalation 2	3.8	4.3	8.9	-1.1	1.9	2.0	2.1	-2.1	2.1	-1.0	-2.4	1.3	2.4	-1.8	-3.0	-2.7
Intermitt. access day 1 inactive lever presses	0.1	0.6	1.7	-1.2	0.6	0.7	0.8	-0.1	0.8	-1.0	-0.3	1.3	0.3	-0.5	0.6	0.1
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.9	-0.6	0.9	0.4	0.5	-0.2	0.6	-0.3	-0.9	0.0	0.2	-0.7	-0.4	-0.2
Intermitt. access escalation Index	0.2	0.2	0.6	0.3	-0.5	-0.4	-0.4	0.3	-0.5	0.7	-0.1	-0.8	-0.3	-0.8	-0.2	0.0
Intermittent access day 1 total infusions	0.8	1.2	3.0	0.7	-0.7	-1.1	-1.0	1.0	-1.0	-0.3	1.4	-0.8	-1.1	1.3	1.7	1.6
Intermittent access day 15 total infusions	0.4	0.5	1.4	-0.5	0.8	0.5	0.6	-0.6	0.6	-0.9	-0.9	0.1	0.7	-1.0	-1.2	-0.6
Intermittent access terminal intake (last 3 days)	1.1	1.4	2.3	-0.7	1.2	1.0	1.1	-1.3	1.2	-1.1	-1.5	0.4	1.3	-1.3	-1.5	-1.3
Intermittent access total infusions	0.1	0.1	0.6	-0.2	0.3	0.2	0.2	-0.2	0.2	-0.8	-0.2	0.0	0.4	-0.2	-0.0	-0.0
Intermittent access day 1 locomotion	0.7	0.9	3.0	-0.6	0.1	-0.3	-0.2	0.4	-0.2	-1.7	1.1	0.6	-0.5	1.0	1.7	1.4
Intermittent access day 15 total locomotion	0.9	1.6	2.2	-1.1	1.5	1.3	1.4	-1.1	1.4	-1.2	-1.5	1.0	1.2	-1.1	-1.4	-1.2
Intermittent access total locomotion	0.3	0.4	2.5	-0.6	0.5	0.5	0.5	-0.3	0.6	-1.6	-0.1	0.8	0.5	0.2	0.2	-0.0
Intermittent access standard deviation	0.6	1.2	3.3	-0.7	1.4	0.9	0.9	-1.1	1.1	-0.4	-1.5	0.2	1.1	-1.2	-1.8	-1.1
Left kidney weight	1.8	8.5	17.7	-4.2	4.2	3.4	3.4	-2.4	3.4	-2.9	-2.6	3.4	1.9	-1.6	-0.9	-1.3
Right kidney weight	2.7	12.1	26.0	-5.1	4.5	4.1	4.0	-2.9	4.0	-3.8	-2.7	4.4	2.5	-1.8	-0.8	-1.5
Cocaine induced anxiety	0.7	0.9	4.4	-0.9	0.6	0.1	0.1	0.9	0.2	-0.7	0.6	0.8	-0.9	1.2	2.1	1.4
Post-drug Anxiety	0.5	0.5	1.2	-1.0	1.1	0.6	0.6	0.6	0.7	-0.1	-0.3	1.0	-0.6	0.5	1.0	0.6
Baseline Anxiety	0.2	0.3	1.2	0.1	0.2	0.2	0.2	-0.2	0.2	0.7	-0.7	-0.1	0.3	-0.7	-1.1	-0.8
Tail length	2.1	8.2	10.6	-3.2	3.2	3.2	3.2	-2.7	3.3	-1.4	-3.3	2.6	2.6	-2.9	-2.4	-2.6
Length with tail	0.8	3.4	6.0	-2.4	2.2	2.0	2.1	-1.8	1.9	-1.2	-1.9	1.7	1.6	-1.9	-1.2	-1.3
Length without tail	0.4	1.2	2.1	-1.4	1.3	1.2	1.2	-1.2	1.0	-1.2	-0.9	0.9	1.2	-1.0	-0.7	-0.7
Times rat made contact with spout	0.1	0.1	0.7	-0.5	0.4	0.0	0.0	-0.1	-0.0	-0.8	0.3	0.1	0.1	0.1	0.5	0.5
Lifetime Intake	0.1	0.1	1.0	-0.2	0.1	0.1	0.1	-0.2	0.1	-1.0	0.1	0.1	0.5	0.0	0.2	0.1
Liver weight, left	3.7	6.1	9.3	-2.8	1.6	2.7	2.7	-2.4	2.7	-1.4	-2.4	2.8	2.7	-3.1	-2.1	-2.5
Liver weight, right	1.2	2.1	4.5	-2.1	1.5	1.5	1.5	-1.7	1.4	-1.9	-1.0	1.6	1.5	-1.3	-0.5	-0.5
Locomotor activity	0.2	0.3	1.1	0.4	-0.4	-0.5	-0.5	0.3	-0.2	0.4	0.8	-0.1	-0.3	1.0	0.8	0.5
Locomotor testing distance	0.6	1.1	2.3	1.0	-0.7	-1.1	-1.1	0.9	-0.9	0.5	1.3	-0.9	-1.0	1.5	1.3	1.3
Locomotor testing rearing	1.0	2.1	3.2	1.8	-1.2	-1.6	-1.7	1.7	-1.4	1.4	1.2	-1.6	-1.5	1.5	0.9	1.1
Locomotion in novel chamber	0.1	0.1	0.4	-0.2	-0.1	-0.1	-0.1	0.1	-0.3	0.5	0.3	-0.1	-0.1	-0.0	0.6	0.6
Locomotion in novel chamber post-restriction	3.1	5.1	7.5	-1.9	1.2	2.5	2.5	-2.5	2.2	-0.9	-2.3	2.3	2.5	-2.7	-2.3	-2.7
Fecal boli incidents, locomotor time 1	0.4	0.5	1.5	0.7	-0.6	-0.9	-0.8	0.5	-0.4	-0.4	1.0	-0.6	0.0	1.2	0.7	0.7
Change in fecal boli incidents, locomotor task	1.8	1.7	2.7	-1.5	1.6	1.3	1.5	-1.2	1.4	-0.5	-1.6	1.1	0.9	-1.6	-1.2	-1.2
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.8	0.3	0.1	-0.0	0.0	-0.3	0.2	0.6	-0.6	-0.5	0.3	-0.4	-0.9	-0.7
Bouts of movement, locomotor time 1	1.3	1.5	2.8	1.6	-1.7	-1.3	-1.4	1.0	-1.3	0.4	1.4	-1.0	-0.9	1.4	0.7	0.9
Total resting periods, locomotor time 1	1.9	2.1	3.7	1.9	-1.9	-1.6	-1.6	1.4	-1.6	0.9	1.5	-1.3	-1.3	1.5	0.8	1.1
Rest time, locomotor task time 1	0.1	0.1	0.3	0.4	-0.6	-0.3	-0.3	0.4	-0.1	0.5	0.0	-0.3	-0.0	-0.1	-0.4	-0.1
Distance moved, locomotor task time 1	0.6	0.8	1.3	0.8	-0.6	-1.1	-1.1	0.7	-0.9	0.4	1.1	-1.1	-0.8	0.7	1.0	1.2
Vertical activity count, locomotor time 1	0.1	0.2	0.6	-0.1	0.2	0.2	0.2	-0.6	0.3	0.5	-0.4	0.1	0.4	-0.8	-0.3	-0.7
Time >=10cm from walls, locomotor time 2	2.7	4.0	8.5	-2.9	1.9	2.0	2.1	-2.0	2.2	-1.3	-2.0	2.3	1.8	-2.2	-1.0	-1.5
Bouts of movement, locomotor time 2	0.3	0.4	1.9	-0.3	-0.1	0.4	0.3	-0.8	0.4	0.0	-0.6	-0.1	0.8	-1.4	-0.9	-0.8
Total resting periods, locomotor time 2	0.3	0.4	2.0	-0.2	-0.2	0.5	0.4	-0.8	0.3	0.2	-0.6	-0.1	0.8	-1.4	-1.0	-0.8
Rest time, locomotor task time 2	1.8	2.3	5.0	2.2	-1.7	-1.4	-1.4	1.7	-1.8	1.6	1.3	-1.4	-1.8	1.5	0.5	0.9
Distance moved, locomotor task time 2	0.2	0.2	0.9	-0.9	0.6	0.1	0.0	-0.2	0.5	-0.5	0.1	0.4	0.4	-0.2	0.6	0.4
Vertical activity count, locomotor time 2	1.0	1.4	3.2	-1.5	1.2	0.9	0.9	-1.3	1.3	-0.2	-1.4	0.8	1.4	-1.8	-0.9	-1.1
Light reinforcement 1	1.4	3.4	6.9	0.7	-1.8	-1.9	-1.8	2.1	-1.9	0.9	2.0	-1.6	-2.0	1.2	2.5	2.6
Light reinforcement 2	1.5	2.2	3.3	1.6	-1.8	-1.4	-1.4	1.7	-1.5	1.3	1.4	-1.5	-1.5	1.3	1.4	1.4
Bone: marrow area	0.3	0.8	1.4	-0.5	0.9	0.8	0.8	-0.9	0.8	-0.6	-1.2	0.3	0.8	-1.1	-1.1	-1.2
Bone: maximum diameter	0.5	0.9	2.0	-1.1	0.8	0.9	0.9	-1.2	0.7	-1.1	-1.0	0.5	0.9	-1.4	-0.9	-0.8
Bone: maximum force	0.4	0.7	1.7	-1.3	1.3	0.8	0.8	-0.7	0.8	-0.7	-0.9	0.5	0.7	-0.9	-0.1	-0.3
Bone: maximum moment	0.3	0.5	1.4	-1.2	1.2	0.7	0.7	-0.6	0.6	-0.6	-0.8	0.3	0.7	-0.7	-0.0	-0.2
Mean time between licks in bursts	0.0	0.1	0.4	0.2	0.1	0.0	0.0	0.2	-0.2	-0.4	0.5	0.4	0.1	0.6	0.2	0.2
Mean num. licks in bursts	0.4	0.6	1.8	-0.2	-0.1	-0.6	-0.6	0.9	-0.4	-0.4	0.9	-0.0	-0.5	0.9	1.3	1.3
Cd content in liver	0.2	0.2	0.5	-0.5	0.3	0.4	0.4	-0.7	0.4	-0.0	-0.4	0.2	0.6	-0.7	-0.3	-0.4
Co content in liver	0.7	0.8	3.0	-0.9	0.9	0.8	0.8	-1.2	0.9	-1.7	-0.3	0.9	1.1	-0.1	-0.5	-0.4
Cu content in liver	0.1	0.2	0.6	0.4	0.3	0.2	0.1	-0.2	0.1	0.4	-0.5	-0.3	0.1	-0.3	-0.7	-0.7
Fe content in liver	2.9	3.5	6.9	2.5	-2.3	-2.2	-2.1	1.9	-2.2	2.6	1.1	-2.3	-1.8	0.1	0.4	0.6
K content in liver	2.7	2.6	3.4	-1.3	1.1	1.8	1.7	-1.6	1.7	-1.5	-1.5	1.7	1.7	-1.4	-1.7	-1.8
Mg content in liver	4.5	4.6	6.7	-1.6	1.8	2.1	2.1	-2.5	2.2	-1.3	-2.4	1.4	2.5	-2.4	-2.6	-2.5
Mn content in liver	0.4	0.5	1.4	-1.2	1.2	0.7	0.7	-0.6	0.8	-0.5	-0.5	0.8	0.6	-0.4	-0.0	-0.0
Na content in liver	0.1	0.2	0.6	0.4	-0.5	0.3	0.2	0.1	0.3	0.3	-0.2	0.5	0.2	-0.2	-0.6	-0.8
Rb content in liver	3.7	4.4	6.7	-2.6	2.6	2.2	2.2	-2.4	2.3	-2.4	-2.0	1.8	1.8	-1.6	-1.4	-1.4
Se content in liver	0.1	0.1	0.4	0.1	0.5	-0.2	-0.2	0.0	-0.2	0.3	-0.2	-0.6	-0.2	-0.1	-0.0	0.2
Sr content in liver	0.1	0.1	0.3	-0.2	-0.1	0.1	0.0	0.1	0.1	-0.6	0.4	0.6	0.1	0.5	0.3	0.2
Zn content in liver	0.8	0.9	3.3	0.5	-0.3	0.4	0.5	-0.5	0.4	0.6	-1.2	0.1	0.9	-1.4	-1.8	-1.8
Bone: minimum diameter	1.1	1.9	5.2	-2.0	1.5	1.4	1.4	-1.5	1.3	-2.3	-0.6	1.8	1.3	-0.1	0.1	-0.3
Time in familiar zone, hab. session 1	0.2	0.2	0.8	0.4	-0.7	0.2	0.2	-0.4	0.1	-0.1	-0.2	0.3	0.6	-0.3	-0.6	-0.9
Time in novel zone, hab. session 1	0.2	0.2	0.9	-0.5	0.8	-0.3	-0.3	0.3	-0.2	0.2	0.1	-0.6	-0.6	0.0	0.5	0.9
Total zone transitions, hab. session 1	0.1	0.2	1.0	0.0	-0.7	0.4	0.3	-0.0	0.3	-0.3	0.2	1.0	0.3	0.4	-0.0	-0.4
Total locomotion distance, hab. session 1	0.1	0.2	1.1	-0.0	-0.6	0.4	0.2	0.2	0.1	-0.2	0.4	1.1	-0.0	0.7	0.5	-0.0
Locomotion velocity, hab. session 1	0.3	0.4	1.2	0.2	-1.0	0.1	-0.0	0.5	-0.1	-0.1	0.8	1.0	-0.3	1.1	0.8	0.2
Time in familiar zone, hab. session 2	0.2	0.2	0.7	-0.1	-0.3	0.1	0.2	-0.7	0.1	-0.2	-0.3	0.1	0.8	-0.8	-0.6	-0.6
Time in novel zone, hab. session 2	0.2	0.2	0.7	-0.4	0.8	0.0	-0.0	0.4	0.0	-0.2	0.1	-0.1	-0.6	0.6	0.6	0.8
Total zone transitions, hab. session 2	0.5	0.7	2.0	-0.6	0.3	1.0	0.9	-0.6	0.9	-1.3	-0.4	1.4	0.8	0.2	-0.4	-0.8
Total locomotion distance, hab. session 2	0.1	0.2	0.7	-0.4	0.0	0.6	0.5	-0.1	0.4	-0.4	-0.2	0.9	0.1	0.2	0.1	-0.3
Locomotion velocity, hab. session 2	0.1	0.1	0.9	-0.2	-0.3	0.5	0.4	0.0	0.3	-0.4	0.0	0.9	0.0	0.3	0.2	-0.2
Novel to familiar place preference ratio	0.1	0.1	0.4	-0.6	0.2	0.2	0.1	0.1	0.1	0.3	0.1	0.4	-0.1	-0.1	0.6	0.5
Novelty place preference	0.1	0.1	0.4	-0.6	0.2	0.2	0.1	0.1	0.1	0.3	0.2	0.3	-0.1	-0.0	0.7	0.6
Time in novel zone, NPP test	0.1	0.1	0.4	-0.6	0.2	0.1	0.1	0.1	0.0	0.4	0.1	0.2	-0.1	-0.1	0.6	0.5
Total zone transitions, NPP test	0.5	0.7	2.1	-0.3	0.5	1.0	0.9	-0.6	0.8	-1.5	-0.5	1.1	0.6	0.3	-0.7	-0.9
Total locomotion distance, NPP test	0.5	0.7	2.1	-0.8	0.9	1.1	1.0	-0.4	0.9	-1.4	-0.3	1.4	0.3	0.8	0.1	-0.3
Locomotion velocity, NPP test	0.6	0.8	2.6	-0.8	0.9	1.2	1.0	-0.4	0.9	-1.6	-0.2	1.5	0.3	0.9	0.2	-0.2
Intraocular pressure	1.9	2.8	4.2	1.6	-1.6	-2.1	-2.0	1.2	-2.0	0.6	2.0	-1.6	-1.3	1.6	1.7	1.8
Delta distance traveled before/after self-admin	0.3	0.4	0.7	0.8	-0.8	-0.8	-0.8	0.6	-0.6	0.0	0.6	-0.8	-0.5	0.4	0.3	0.4
Delta ambulatory time before/after self-admin	1.1	1.4	1.8	1.3	-1.4	-1.3	-1.3	1.3	-1.2	0.8	1.2	-1.2	-1.3	0.9	0.9	1.0
Parametrial fat weight	0.3	0.6	1.4	0.1	-0.5	-0.4	-0.6	1.1	-0.5	0.1	1.1	0.1	-1.1	1.0	1.2	1.1
Pavlov. Cond. lever latency	0.5	0.6	1.3	-0.4	0.8	0.4	0.4	-0.9	0.4	-0.4	-0.8	-0.3	1.1	-1.2	-1.1	-0.7
Pavlov. Cond. magazine entry latency	2.0	2.6	5.1	0.9	-1.4	-1.5	-1.4	2.0	-1.4	2.0	1.3	-1.3	-2.2	1.2	1.9	1.8
Pavlov. Cond. change in total contacts	0.3	0.3	1.9	0.3	0.0	-0.1	-0.1	0.8	-0.1	1.4	-0.2	-0.4	-1.0	0.2	0.2	0.2
Pavlov. Cond. index score	1.3	1.7	3.1	0.9	-1.4	-1.1	-1.1	1.6	-1.1	1.4	1.2	-0.6	-1.8	1.3	1.6	1.3
Pavlov. Cond. latency score	1.2	1.5	3.0	0.7	-1.4	-0.9	-0.9	1.5	-0.9	1.1	1.3	-0.3	-1.6	1.3	1.7	1.3
Pavlov. Cond. lever contacts	0.8	0.9	2.0	0.6	-1.1	-0.7	-0.7	1.3	-0.7	0.9	1.0	-0.0	-1.4	1.3	1.3	0.9
Pavlov. Cond. magazine entry number	1.2	1.5	3.4	-0.6	0.9	1.1	1.1	-1.6	1.0	-1.4	-1.0	1.0	1.8	-0.9	-1.6	-1.5
Pavlov. Cond. intertrial magazine entries	0.7	0.9	3.4	0.4	0.1	-0.0	0.1	-0.9	0.1	0.5	-0.9	-0.7	1.2	-1.5	-1.8	-1.3
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.6	3.0	0.9	-1.2	-1.1	-1.0	1.5	-1.0	1.4	1.1	-0.7	-1.7	1.3	1.5	1.2
Pavlov. Cond. response bias	1.6	1.9	4.5	1.2	-1.1	-1.3	-1.2	1.8	-1.2	1.7	0.9	-1.3	-2.1	1.1	1.3	1.3
Pavlov. Cond. lever latency	0.1	0.1	0.4	0.5	0.1	0.3	0.3	-0.2	0.4	-0.2	-0.1	0.4	0.1	0.4	-0.5	-0.6
Pavlov. Cond. magazine entry latency	1.1	1.3	2.7	0.8	-0.9	-1.2	-1.3	1.4	-1.3	1.6	0.6	-1.6	-1.3	-0.2	0.8	1.1
Pavlov. Cond. change in total contacts	0.4	0.7	3.0	0.6	-0.7	-0.8	-0.8	1.1	-0.8	1.7	0.1	-1.1	-0.7	-0.4	0.3	0.4
Pavlov. Cond. index score	0.6	0.8	2.2	0.4	-0.6	-0.9	-0.9	1.0	-1.0	1.5	0.1	-1.4	-0.8	-0.6	0.4	0.6
Pavlov. Cond. latency score	0.5	0.7	2.0	0.4	-0.5	-0.8	-0.8	0.9	-1.0	1.4	0.1	-1.3	-0.8	-0.6	0.3	0.6
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.5	-0.3	-0.3	-0.3	0.2	-0.5	0.3	0.2	-0.3	0.1	-0.5	0.5	0.5
Pavlov. Cond. magazine entry number	0.6	0.7	2.1	-0.5	0.5	0.8	0.9	-1.1	0.9	-1.4	-0.0	1.4	0.9	0.6	-0.3	-0.5
Pavlov. Cond. intertrial magazine entries	0.8	1.2	2.5	-1.3	1.2	1.1	1.1	-1.5	1.2	-1.6	-0.4	1.5	1.2	0.1	-0.2	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	2.2	0.4	-0.6	-0.9	-0.9	1.0	-1.0	1.5	0.2	-1.4	-0.8	-0.6	0.4	0.7
Pavlov. Cond. response bias	0.3	0.4	0.8	-0.1	-0.4	-0.6	-0.6	0.6	-0.7	0.9	0.1	-0.9	-0.2	-0.8	0.4	0.6
Time in closed arm before self-admin	2.1	2.6	4.2	1.9	-2.0	-2.0	-2.0	1.4	-1.7	1.5	1.7	-1.7	-1.0	1.5	1.0	1.1
Time in closed arm after self-admin	2.0	2.1	3.7	1.8	-1.5	-1.6	-1.6	1.4	-1.9	1.9	0.9	-1.9	-1.6	0.6	0.4	0.7
Time in open arm before self-admin	0.3	0.3	1.6	-0.8	0.5	0.6	0.6	-0.6	0.1	-1.3	0.0	0.7	0.2	-0.4	0.2	0.2
Time in open arm after self-admin	3.8	4.1	5.9	-1.9	2.3	2.2	2.2	-2.2	2.3	-1.1	-2.4	1.4	2.0	-2.1	-1.9	-1.9
Bone: periosteal estimation	0.6	1.2	1.8	-1.2	1.2	1.0	1.0	-1.3	0.9	-1.3	-1.2	0.6	1.2	-1.1	-0.8	-0.9
Bone: periosteal perimeter	0.5	0.9	4.1	-1.3	1.1	0.8	0.8	-1.0	0.8	-2.0	-0.6	0.8	0.8	-0.5	-0.2	-0.2
Bone: post-yield work	0.3	0.4	0.7	-0.4	0.8	0.8	0.8	-0.3	0.8	-0.1	-0.8	0.9	0.3	-0.1	-0.4	-0.7
Progressive ratio test 1 active lever presses	0.3	0.3	0.7	0.5	-0.6	-0.7	-0.6	0.6	-0.6	-0.0	0.6	-0.6	-0.4	0.4	0.9	0.7
Progressive ratio test 1 breakpoint	0.3	0.4	0.9	0.5	-0.6	-0.6	-0.6	0.7	-0.6	-0.0	0.6	-0.5	-0.5	0.5	0.9	0.7
Progressive ratio test 1 inactive lever presses	0.3	0.5	1.0	0.6	-0.4	-0.9	-0.7	1.0	-0.6	0.2	0.5	-0.9	-0.8	0.4	0.4	1.0
Progressive ratio test 2 active lever presses	0.1	0.2	0.5	0.6	-0.4	-0.6	-0.4	0.4	-0.4	0.2	0.2	-0.7	-0.2	-0.0	0.1	0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.4	0.4	-0.3	-0.4	-0.3	0.3	-0.2	0.1	0.0	-0.6	0.0	-0.2	-0.1	0.1
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.2	0.0	0.3	-0.2	-0.0	0.2	-0.0	-0.3	-0.2	-0.5	-0.1	-0.2	0.3	0.2
Incentive Sensitization - Responses	0.0	0.1	0.4	0.1	0.1	-0.1	0.0	-0.2	0.1	-0.3	-0.1	-0.2	0.4	-0.1	-0.6	-0.1
Incentive Sensitization - Breakpoint	0.0	0.1	0.4	0.1	0.0	-0.1	-0.0	-0.1	0.0	-0.2	-0.1	-0.3	0.3	-0.2	-0.6	-0.1
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.7	0.1	0.4	0.4	0.4	-0.2	0.3	0.5	-0.7	0.1	0.1	-0.5	-0.9	-0.8
Progressive ratio	0.2	0.3	0.9	0.0	-0.3	0.4	0.4	-0.2	0.6	0.7	-0.4	0.5	0.7	-0.7	-0.8	-1.0
Food seeking constrained by brief footshock	0.1	0.1	0.5	0.0	-0.2	-0.1	-0.1	0.3	-0.2	-0.1	0.4	0.3	-0.7	0.1	0.7	0.4
Seeking ratio, punishment vs. effort	0.6	0.8	1.9	0.4	-0.3	-0.8	-0.8	0.7	-1.0	-0.2	0.9	-0.8	-1.3	0.8	1.3	1.4
Retroperitoneal fat weight	0.4	1.9	6.7	-2.6	1.5	1.6	1.3	-1.0	1.4	-1.3	-1.0	1.4	0.9	-1.6	-0.1	-0.1
Reaction time number correct	2.8	5.5	8.1	-2.3	2.6	2.5	2.5	-2.5	2.4	-0.8	-2.8	1.6	2.2	-2.7	-2.4	-2.3
Reaction time mean minus median	0.3	0.7	1.4	-1.0	0.5	1.0	0.9	-0.9	0.7	-0.8	-0.6	1.2	0.8	-1.2	-0.2	-0.6
Reaction time mean minus median AUC	0.6	1.4	2.9	-1.7	1.1	1.4	1.3	-1.1	1.1	-1.2	-1.0	1.5	1.0	-1.5	-0.4	-0.6
Reaction time num false alarms	0.3	0.5	1.1	0.2	-0.1	-0.5	-0.5	0.8	-0.8	0.4	0.5	-0.6	-1.0	1.0	0.9	0.9
Reaction time num false alarms AUC	0.3	0.5	1.0	0.6	-0.3	-0.6	-0.6	0.9	-0.8	0.9	0.4	-0.8	-1.0	0.7	0.7	0.7
Reaction time trials correct on left	2.8	5.5	8.1	-2.3	2.6	2.5	2.5	-2.5	2.4	-0.8	-2.8	1.6	2.2	-2.7	-2.4	-2.3
Reaction time trials on left	2.8	5.3	7.9	-2.3	2.5	2.5	2.4	-2.4	2.3	-0.7	-2.8	1.6	2.1	-2.7	-2.4	-2.2
Reaction time mean	0.5	0.7	2.1	1.3	-1.5	-0.9	-0.9	0.5	-1.1	1.0	0.4	-1.1	-0.6	-0.5	-0.1	-0.0
Reaction time mean AUC	0.2	0.3	1.2	0.8	-1.1	-0.5	-0.5	0.1	-0.7	0.4	0.2	-0.7	-0.3	-0.6	-0.1	-0.2
Median of all reaction times	1.4	2.0	4.4	2.1	-2.1	-1.6	-1.6	1.1	-1.7	1.7	0.9	-1.9	-1.2	0.2	0.2	0.4
Reaction time omissions	0.1	0.1	0.7	-0.4	-0.0	-0.1	-0.1	0.2	-0.3	0.1	0.3	0.3	-0.5	-0.1	0.8	0.7
Reaction time false alarm rate	2.0	2.7	3.5	1.5	-1.5	-1.7	-1.6	1.8	-1.8	1.1	1.7	-1.4	-1.8	1.9	1.8	1.7
Reaction time premature initiation rate	1.9	2.7	4.4	1.8	-2.1	-1.6	-1.7	2.1	-1.7	2.0	1.5	-1.3	-1.7	1.1	1.1	1.2
Reaction time premature initiations	0.2	0.4	2.2	0.6	-0.7	-0.3	-0.4	0.7	-0.5	1.5	-0.0	-0.5	-0.6	-0.3	-0.2	0.0
Std. dev. reaction times	0.2	0.3	1.3	-0.6	-0.0	0.5	0.5	-0.7	0.1	-0.7	-0.2	0.6	0.5	-1.1	-0.0	-0.3
Reaction time trials completed	2.8	5.3	7.9	-2.3	2.5	2.5	2.4	-2.4	2.3	-0.7	-2.8	1.6	2.1	-2.7	-2.4	-2.2
Reaction time trials AUC	2.5	4.9	8.0	-2.1	2.4	2.3	2.3	-2.3	2.1	-0.4	-2.8	1.3	2.0	-2.8	-2.5	-2.2
Run reversals in cocaine runway, females	1.5	1.5	2.4	-0.8	1.3	1.3	1.5	-0.9	1.3	-0.4	-1.5	1.0	0.8	-1.2	-1.5	-1.5
Run reversals in cocaine runway, males	0.6	0.6	1.4	1.1	-0.5	-0.9	-0.9	0.8	-0.8	0.7	0.6	-1.2	-0.7	1.0	0.1	0.7
Latency to leave start box in cocaine runway	0.1	0.2	0.7	0.4	-0.8	-0.3	-0.1	0.2	-0.3	0.8	0.0	-0.2	-0.1	-0.5	-0.1	-0.2
Latency to leave start box in cocaine runway, F	0.1	0.1	0.5	0.2	-0.7	-0.2	0.1	0.0	-0.2	-0.2	0.3	0.5	0.1	-0.0	0.0	-0.2
Latency to leave start box in cocaine runway, M	0.6	0.5	3.5	0.4	-0.4	-0.3	-0.3	0.5	-0.2	1.9	-0.5	-1.1	-0.5	-0.9	-0.3	-0.0
Std. dev. time between licks in bursts	0.9	1.3	3.1	-1.6	1.2	1.1	1.1	-1.2	1.1	-1.8	-0.4	1.4	1.3	-0.4	-0.0	-0.2
Total sessions with >9 infusions	0.6	0.8	2.2	0.3	-1.0	-0.7	-0.6	0.4	-0.7	-0.9	1.5	0.0	-0.1	1.0	1.5	1.0
Short access day 1 total inactive lever presses	1.6	2.1	5.4	-1.8	1.4	1.5	1.7	-1.3	1.5	-2.3	-0.7	2.0	1.2	-0.6	-0.7	-0.7
Short access day 10 total inactive lever presses	0.5	1.2	2.6	-1.1	1.6	1.1	1.3	-0.4	1.2	0.4	-1.6	1.0	-0.1	-1.2	-0.9	-0.9
Short access day 1 total infusions	0.2	0.2	1.0	0.1	-0.3	-0.1	-0.0	0.0	-0.2	-1.0	0.7	0.4	0.1	0.7	0.8	0.4
Short access day 10 total infusions	0.2	0.3	1.0	0.4	-1.0	-0.5	-0.4	0.4	-0.5	-0.3	0.9	-0.0	-0.1	0.5	0.7	0.5
Short access total infusions	0.2	0.2	1.0	0.0	-0.6	-0.1	-0.1	-0.3	-0.2	-1.0	0.6	0.2	0.5	0.1	0.7	0.1
Short access day 1 locomotion	1.2	1.5	2.8	1.0	-1.3	-1.3	-1.2	1.0	-1.3	-0.0	1.6	-0.7	-1.0	1.4	1.7	1.4
Short access day 10 total locomotion	1.0	1.9	6.5	-1.8	1.5	1.3	1.4	-1.2	1.3	-2.6	-0.4	2.0	1.0	0.1	0.2	-0.2
Short access total locomotion	0.7	0.9	3.2	-0.6	-0.2	-0.2	-0.1	0.2	-0.2	-1.8	1.2	0.9	-0.2	1.1	1.6	1.2
One hour access (0.3 mA shock)	1.1	1.2	3.7	0.0	1.1	0.7	0.8	-0.9	0.8	0.4	-1.8	-0.5	0.8	-1.4	-1.9	-1.5
Compulsive drug intake	1.5	1.8	4.6	-0.5	1.0	1.1	1.0	-1.5	1.0	0.3	-1.8	0.1	1.0	-2.1	-1.9	-1.8
One hour access (shock baseline)	0.4	0.6	1.1	0.7	-0.5	-0.9	-0.8	1.1	-0.7	0.3	0.6	-0.9	-0.7	1.0	0.5	0.9
Social response proportion	1.5	1.7	7.4	1.4	-1.2	-1.0	-1.0	1.6	-1.3	2.7	-0.0	-1.6	-1.6	-0.6	-0.2	0.2
Social responses	4.0	5.1	10.6	2.7	-2.3	-2.5	-2.5	2.5	-2.4	3.3	1.3	-3.1	-2.3	0.4	0.8	1.5
Social time	0.2	0.3	0.7	0.6	-0.5	-0.5	-0.5	0.1	-0.3	0.8	-0.2	-0.8	0.1	-0.8	-0.7	-0.4
Soleus weight	0.1	0.3	0.9	0.6	-0.8	-0.5	-0.4	0.2	-0.5	0.8	-0.2	-1.0	-0.1	-0.9	-0.6	-0.3
Bone: stiffness	0.3	0.5	1.0	-1.0	0.9	0.8	0.8	-0.4	0.7	-0.4	-0.8	0.6	0.5	-0.8	-0.3	-0.5
Tibialis anterior weight	0.2	0.6	2.5	0.4	-0.2	-0.2	-0.1	-0.2	-0.2	1.1	-0.9	-1.1	0.1	-1.6	-1.2	-0.8
Time to tail flick, vehicle, before self-admin	0.4	0.4	2.6	-0.7	0.0	0.3	0.3	-0.2	0.3	-1.6	0.5	1.1	0.5	0.3	0.4	0.1
Time to tail flick, vehicle, after self-admin	0.6	0.8	2.7	-0.7	0.6	0.7	0.7	-1.2	1.0	-1.1	-0.6	0.6	1.6	-0.6	-0.8	-0.9
Time to tail flick, test, before self-admin	0.2	0.2	0.5	0.1	-0.6	-0.3	-0.3	0.4	-0.4	-0.4	0.7	0.1	-0.2	0.4	0.6	0.6
Time to tail flick, test, after self-admin	0.4	0.4	1.0	-0.8	0.3	0.7	0.7	-0.5	0.8	-0.3	-0.4	0.9	1.0	-0.7	-0.4	-0.5
Delta time to tail flick, vehicle, before/after SA	1.7	1.6	3.1	-0.9	1.5	1.1	1.1	-1.3	1.3	0.2	-1.8	0.2	1.4	-1.6	-1.5	-1.4
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	-0.3	0.2	0.1	0.1	-0.3	0.4	0.2	-0.2	0.2	0.6	-0.2	-0.3	-0.3
Tibia length	0.3	0.9	2.8	-1.1	0.4	0.2	0.2	0.5	0.0	-1.3	0.8	1.0	-0.6	1.2	1.7	1.4
Ambulatory time before self-admin	0.6	0.9	1.4	-1.2	0.8	1.1	1.1	-1.1	1.1	-0.9	-0.8	1.2	1.0	-0.8	-0.5	-0.7
Ambulatory time after self-admin	0.2	0.2	0.6	0.7	-0.5	-0.3	-0.3	0.3	-0.4	0.8	-0.0	-0.7	-0.5	-0.1	-0.1	-0.1
Bone: tissue strength	0.2	0.2	0.7	-0.7	0.8	0.4	0.4	0.0	0.5	-0.5	-0.1	0.6	0.2	0.4	0.4	0.3
Total heroin consumption	0.1	0.2	0.5	-0.3	0.2	0.6	0.6	-0.6	0.3	-0.2	-0.2	0.7	0.0	0.4	0.1	-0.3
Bone: trabecular number	2.5	4.1	6.0	-1.9	2.1	2.2	2.2	-1.9	2.2	-1.3	-2.4	1.5	2.1	-2.1	-2.0	-2.1
Bone: trabecular spacing	3.4	4.5	7.3	1.6	-2.2	-2.3	-2.3	1.9	-2.3	0.9	2.7	-1.6	-1.9	2.2	2.4	2.5
Bone: trabecular thickness	0.6	0.7	2.1	0.2	0.0	0.5	0.5	-0.8	0.5	0.2	-1.1	-0.2	0.9	-1.2	-1.4	-1.5
Bone: trabecular tissue density	0.5	0.7	2.6	0.8	0.3	0.5	0.5	-0.2	0.5	1.2	-1.1	0.1	0.3	-0.4	-1.6	-1.5
Water consumed over 24 hours	0.4	0.5	1.3	0.9	-0.5	-0.8	-0.8	0.5	-0.9	1.1	0.3	-1.1	-0.6	-0.0	-0.0	0.3
Number of responses in last shaping day	1.2	1.4	2.5	0.9	-1.1	-1.2	-1.2	1.0	-1.2	0.0	1.5	-1.1	-1.5	1.1	1.1	1.6