H2-M10.6l

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2
Bone: apparent density1.01.93.5-0.1-1.81.81.81.0-1.91.1-0.9-1.01.81.2-1.01.51.41.6-1.1
Area under the delay curve1.82.83.6-1.21.1-1.8-1.8-1.81.4-1.91.71.8-1.7-1.81.6-1.8-1.9-1.81.8
BMI with tail1.24.47.3-2.70.0-2.0-1.9-2.51.2-0.72.72.5-1.7-2.42.5-2.2-2.0-1.62.7
BMI without tail1.68.311.3-2.71.1-3.0-2.9-3.42.2-2.63.13.2-2.9-3.23.1-3.1-2.9-2.63.3
Body weight5.222.730.4-1.94.6-5.5-5.5-4.75.4-4.44.34.3-5.4-4.84.2-5.1-5.4-4.94.7
Weight adjusted by age0.92.55.9-0.02.0-1.6-1.6-1.42.4-2.11.21.2-1.9-1.41.2-1.5-1.5-1.71.1
Bone surface0.10.10.50.60.7-0.3-0.20.00.4-0.6-0.2-0.3-0.10.0-0.30.0-0.5-0.4-0.1
Bone volume0.00.00.2-0.10.10.00.0-0.20.0-0.50.10.00.0-0.10.00.0-0.3-0.10.0
Breakpoint value in progressive ratio session0.40.73.90.3-0.40.60.60.8-0.52.0-0.5-0.70.70.7-0.60.61.21.0-0.6
Number of licking bursts0.10.21.01.00.60.30.20.50.3-0.1-0.5-0.6-0.10.3-0.50.2-0.3-0.6-0.2
Context. condit. distance diff. score6.37.711.23.3-0.32.82.83.3-1.52.2-3.3-3.32.43.1-3.33.02.32.4-3.2
Locomotion velocity, session 10.40.41.01.00.10.70.60.8-0.10.5-0.9-0.80.50.7-0.90.70.40.1-0.8
Locomotion distance, session 10.70.92.4-0.4-1.51.11.10.5-1.41.2-0.4-0.41.10.7-0.40.81.21.1-0.6
Locomotion velocity, session 20.10.10.30.40.30.40.30.20.30.5-0.3-0.2-0.00.1-0.20.10.1-0.5-0.1
Locomotion distance, session 20.71.01.50.4-1.01.11.10.8-1.11.1-0.8-0.91.11.0-0.91.01.11.2-0.9
Locomotion velocity, session 30.10.20.7-0.8-0.50.30.4-0.4-0.30.30.60.50.1-0.30.5-0.2-0.1-0.10.4
Locomotion distance, session 31.41.62.80.5-1.21.71.71.2-1.41.1-1.1-1.11.41.2-1.11.41.41.5-1.2
Stereotopy head waving bouts, day 30.70.82.30.71.5-1.3-1.2-0.31.3-0.50.10.2-1.0-0.50.1-0.7-1.2-1.10.5
Stereotopy head waving duration, day 30.70.81.60.21.3-1.3-1.2-0.61.2-0.50.50.5-1.1-0.70.4-0.9-1.2-1.20.7
Locomotion velocity, session 73.84.16.31.3-1.62.52.42.1-2.01.3-2.0-2.02.32.1-2.02.32.11.8-2.1
Locomotion distance, session 72.73.46.60.6-1.92.62.41.6-2.11.4-1.5-1.52.11.8-1.62.01.92.1-1.7
Stereotopy head waving bouts, day 71.82.13.9-0.51.5-1.6-1.5-1.31.6-1.61.21.2-1.5-1.41.1-1.4-1.8-2.01.3
Stereotopy head waving duration, day 72.02.44.2-0.51.6-1.7-1.7-1.41.7-1.71.31.3-1.7-1.51.3-1.6-1.9-2.11.4
Locomotion velocity, session 81.11.36.22.52.00.20.21.21.20.1-1.4-1.4-0.30.8-1.30.5-0.3-0.4-1.0
Locomotion distance, session 83.85.67.72.6-0.42.62.52.7-1.31.9-2.6-2.72.12.6-2.82.52.02.4-2.7
Degree of sensitization distance0.10.10.60.80.50.30.20.40.2-0.1-0.5-0.5-0.00.3-0.50.3-0.1-0.0-0.4
Degree of sensitization stereotypy0.70.71.6-0.50.7-0.9-0.7-0.80.8-1.00.80.8-0.8-0.90.8-0.8-1.1-1.30.8
Conditioned locomotion1.92.23.7-0.71.4-1.6-1.6-1.31.7-1.21.31.3-1.8-1.51.3-1.6-1.7-1.91.5
Cocaine response after cond. corrected0.20.41.6-0.1-0.60.91.00.4-0.61.3-0.2-0.20.60.4-0.20.50.60.2-0.4
Cocaine response after cond. not corrected0.10.20.70.30.8-0.3-0.3-0.10.70.10.20.1-0.6-0.30.1-0.4-0.6-0.90.2
Cocaine response before conditioning4.55.510.20.02.8-2.9-2.9-1.92.9-3.21.51.4-2.7-2.01.5-2.3-2.8-2.61.8
Saline control response1.82.54.5-1.9-0.1-1.5-1.5-2.00.7-2.11.91.8-1.3-1.71.8-1.6-1.3-1.21.7
Bone: connectivity density2.33.65.10.9-1.82.32.21.8-2.11.4-1.8-1.82.32.0-1.82.11.82.0-1.9
Bone: cortical apparent density0.61.03.0-1.7-0.2-0.4-0.4-1.30.3-0.51.51.4-0.7-1.21.4-1.0-0.7-0.61.2
Bone: cortical area0.81.32.1-0.21.3-1.3-1.3-1.11.5-1.11.00.9-1.3-1.10.9-1.2-1.2-0.91.0
Bone: cortical porosity0.20.20.6-0.40.0-0.3-0.4-0.60.2-0.80.50.4-0.4-0.50.5-0.5-0.3-0.30.6
Bone: cortical porosity0.20.21.10.10.4-0.5-0.5-0.40.5-1.10.30.2-0.6-0.40.3-0.4-0.4-0.40.4
Bone: cortical thickness2.03.36.5-2.50.2-1.4-1.4-2.30.9-1.12.42.3-1.5-2.12.4-1.9-1.4-1.12.1
Bone: cortical thickness1.01.34.9-2.2-0.9-0.9-0.8-1.3-0.1-0.31.51.4-0.5-1.21.5-1.0-0.5-0.31.3
Bone: cortical tissue density0.50.92.5-1.6-0.2-0.4-0.4-1.20.3-0.51.31.3-0.6-1.11.3-0.9-0.6-0.61.1
Condit. Reinf. active minus inactive responses0.10.20.40.2-0.20.70.60.4-0.30.5-0.3-0.20.40.3-0.30.40.40.3-0.4
Condit. Reinf. active-inactive response ratio0.40.40.9-0.90.1-0.5-0.5-0.80.3-0.20.80.9-0.4-0.80.8-0.7-0.5-0.70.9
Condit. Reinf. active responses0.60.71.60.3-0.71.31.20.7-0.81.1-0.5-0.51.00.8-0.60.81.01.1-0.8
Condit. Reinf. inactive responses2.02.64.80.2-1.92.02.01.2-1.81.7-1.0-1.01.81.4-1.01.51.92.2-1.5
Incentive salience index mean0.91.12.11.50.01.00.91.4-0.41.2-1.2-1.20.91.2-1.31.00.90.9-1.1
Condit. Reinf. lever presses3.24.88.12.8-0.11.81.82.8-0.92.5-2.6-2.51.82.5-2.72.21.92.0-2.3
Condit. Reinf. active minus inactive responses0.71.02.3-0.10.9-1.5-1.5-0.91.0-1.50.70.7-1.1-0.90.6-1.0-0.9-1.10.8
Condit. Reinf. active-inactive response ratio1.32.04.5-0.01.7-2.1-2.1-1.11.7-1.40.80.9-1.6-1.20.8-1.4-1.6-1.81.3
Condit. Reinf. active responses0.10.10.20.5-0.2-0.1-0.10.3-0.3-0.2-0.4-0.40.20.4-0.40.30.40.4-0.4
Condit. Reinf. inactive responses0.91.32.50.5-1.11.61.61.0-1.20.9-0.9-0.91.11.1-0.91.11.31.5-1.2
Condit. Reinf. lever presses1.31.92.91.2-0.91.11.11.5-1.30.4-1.5-1.41.41.6-1.51.51.61.7-1.7
Condit. Reinf. lever reinforcers received0.20.30.50.7-0.20.20.20.6-0.40.0-0.7-0.70.50.6-0.70.60.60.6-0.7
Conditioned reinforcement - actives0.41.53.0-1.50.3-1.1-1.0-1.50.9-1.71.51.4-1.0-1.41.3-1.3-0.9-1.01.2
Conditioned reinforcement - inactives0.41.02.1-1.5-0.1-0.9-0.8-1.20.7-1.21.31.2-1.0-1.11.2-1.1-0.5-0.50.9
Conditioned locomotion0.30.41.2-0.30.5-0.7-0.7-0.70.6-1.10.60.7-0.5-0.70.5-0.7-0.7-0.60.6
Patch foraging indifference point 0 sec0.20.42.1-1.1-1.20.30.4-0.6-0.8-1.50.30.50.3-0.30.40.10.10.30.1
Patch foraging indifference point AUC0.92.13.4-0.71.3-1.5-1.4-1.51.5-1.71.41.4-1.8-1.51.5-1.6-1.4-1.21.2
Delay disc. indifference point, 0s delay0.70.81.4-0.01.1-1.1-1.1-0.71.0-0.50.60.7-1.1-0.80.6-0.9-1.1-1.20.8
Delay disc. indifference point, 16s delay1.72.45.5-2.4-0.3-1.2-1.2-2.00.5-1.61.91.9-1.2-1.81.9-1.5-1.2-1.01.7
Delay disc. indifference point, 2s delay2.12.33.5-0.51.6-1.8-1.8-1.41.7-1.41.31.3-1.8-1.51.2-1.6-1.7-1.91.5
Delay disc. indifference point, 24s delay0.61.02.0-1.10.2-0.7-0.7-1.20.5-1.41.21.2-0.7-1.11.1-0.9-1.1-1.11.2
Delay disc. indifference point, 4s delay3.94.26.1-0.72.1-2.5-2.5-1.92.2-2.01.71.7-2.4-2.01.7-2.1-2.2-2.31.9
Delay disc. indifference point, 8s delay0.40.61.8-0.60.3-0.8-0.8-0.90.5-1.30.90.9-0.5-0.80.6-0.8-0.9-0.60.7
Indifference point function ln k0.30.91.71.3-0.20.90.91.1-0.20.4-1.1-1.20.71.1-1.21.00.70.6-1.1
Indifference point function log k0.30.91.71.3-0.20.90.91.1-0.20.4-1.1-1.20.71.1-1.21.00.70.6-1.1
Patch foraging total patch changes 0 sec0.20.63.0-1.4-1.20.10.2-0.8-0.7-1.70.60.70.1-0.50.7-0.1-0.10.20.3
Patch foraging total patch changes 12 sec0.71.02.9-1.7-0.7-0.8-0.7-1.4-0.2-1.41.11.3-0.6-1.01.3-0.8-0.20.10.8
Patch foraging total patch changes 18 sec0.30.73.5-1.6-1.90.70.8-0.3-1.50.00.40.50.6-0.10.50.30.40.90.1
Patch foraging total patch changes 24 sec0.31.04.5-1.9-2.10.80.9-0.6-1.6-0.70.60.61.0-0.20.60.40.80.80.0
Patch foraging total patch changes 6 sec1.01.85.5-2.3-1.1-0.5-0.4-1.8-0.4-1.81.51.7-0.8-1.51.7-1.0-0.8-0.41.2
Patch foraging time to switch 0 sec0.10.41.7-1.0-1.30.30.4-0.0-1.01.30.20.20.6-0.00.20.20.30.10.4
Patch foraging water rate 0 sec0.10.44.0-0.40.2-0.6-0.7-0.80.4-2.00.40.5-0.4-0.50.3-0.4-0.4-0.10.2
Patch foraging water rate 12 sec0.00.10.6-0.7-0.80.10.1-0.3-0.5-0.10.40.10.2-0.10.1-0.10.30.30.0
Patch foraging water rate 18 sec0.00.10.70.00.2-0.2-0.3-0.20.1-0.80.20.1-0.0-0.20.1-0.20.0-0.10.0
Patch foraging water rate 24 sec0.40.60.9-0.70.4-0.8-0.9-0.90.5-0.80.60.7-0.8-0.90.8-0.8-0.8-0.50.9
Patch foraging water rate 6 sec0.10.10.6-0.7-0.70.10.0-0.2-0.5-0.20.30.00.3-0.00.2-0.00.50.30.0
Seeking ratio, delayed vs. immediate footshock0.40.51.4-0.20.8-1.1-1.1-0.50.8-0.40.60.4-0.7-0.60.5-0.8-0.6-1.20.7
Distance traveled before self-admin0.10.31.61.31.0-0.1-0.10.50.50.1-0.5-0.7-0.20.5-0.50.10.10.5-0.6
Distance traveled after self-admin0.30.42.10.71.4-0.8-0.8-0.21.0-0.30.20.1-0.7-0.30.2-0.6-0.8-0.60.2
Extensor digitorum longus weight0.10.51.81.40.4-0.0-0.00.70.1-1.1-0.9-1.00.30.7-0.90.60.10.1-0.7
Bone: elastic displacement0.40.51.0-1.0-0.4-0.6-0.5-0.8-0.1-0.90.80.8-0.5-0.80.8-0.7-0.6-0.90.9
Bone: elastic work1.01.32.2-0.90.6-1.2-1.1-1.20.8-1.21.11.2-1.2-1.31.2-1.2-1.3-1.21.5
Bone: endosteal estimation1.43.412.22.23.5-2.2-2.1-0.42.9-1.7-0.1-0.0-2.1-0.7-0.1-1.2-2.3-2.20.7
Bone: endosteal perimeter0.81.89.83.11.9-0.2-0.11.41.1-0.2-1.8-1.7-0.01.2-1.80.8-0.1-0.1-1.2
Epididymis fat weight1.99.642.0-6.5-3.4-1.2-1.2-3.9-1.4-0.94.14.2-0.7-3.23.9-2.3-1.0-0.43.3
Delta time in closed arm before/after self-admin0.50.50.9-0.70.2-0.8-0.8-0.80.5-0.90.80.7-0.6-0.70.7-0.6-0.6-0.80.6
Delta time in open arm before/after self-admin0.10.20.70.10.7-0.4-0.4-0.40.4-0.80.50.3-0.4-0.30.3-0.4-0.30.1-0.0
Diff in mean of infusions in LGA sessions2.34.15.90.7-2.32.22.22.0-2.12.4-1.8-1.82.42.0-1.72.02.32.2-1.8
Delay discount exponential model param2.22.93.71.2-1.11.81.81.9-1.51.9-1.7-1.81.71.8-1.61.81.91.8-1.8
Extinction: sum of active levers before priming0.81.34.20.3-0.81.21.21.1-0.92.1-0.8-0.91.21.1-0.81.01.51.4-0.9
Active lever presses in extinction session 60.30.31.6-1.2-0.80.10.1-0.3-0.51.00.60.60.1-0.30.6-0.20.50.40.4
Bone: final force2.74.46.5-1.91.0-2.6-2.5-2.41.6-1.52.22.3-2.0-2.32.2-2.3-2.1-1.72.5
Bone: final moment2.23.65.5-1.61.0-2.4-2.3-2.21.5-1.62.02.0-1.8-2.01.9-2.0-1.9-1.52.2
Food consumed during 24 hour testing period0.30.61.90.91.4-0.9-0.9-0.11.2-0.50.0-0.1-0.8-0.3-0.1-0.5-0.9-1.10.3
Glucose3.04.716.14.01.20.80.72.9-0.10.1-3.1-3.21.42.5-3.12.11.00.7-2.3
Heart weight2.64.26.6-1.41.5-1.9-1.9-2.32.0-2.62.21.9-1.8-2.22.0-2.1-2.3-2.22.0
Delay discount hyperbolic model param2.33.03.51.2-1.11.91.91.9-1.51.8-1.8-1.81.81.9-1.71.81.91.8-1.8
Intermittent access intake day 1-15 change0.00.00.10.00.3-0.1-0.1-0.10.10.00.30.0-0.1-0.10.1-0.20.0-0.0-0.0
Intermittent access intake escalation0.10.40.8-0.70.4-0.6-0.6-0.80.5-0.40.90.7-0.7-0.70.8-0.8-0.5-0.50.7
Intermittent access intake escalation 20.10.21.11.01.1-0.2-0.20.10.6-0.4-0.0-0.3-0.20.2-0.3-0.0-0.1-0.1-0.3
Intermitt. access day 1 inactive lever presses0.00.31.91.40.8-0.1-0.10.60.60.3-0.6-0.70.00.5-0.60.3-0.10.0-0.4
Intermitt. access day 15 inactive lever presses0.10.31.10.40.4-0.5-0.6-0.30.6-1.00.20.2-0.4-0.3-0.0-0.3-0.9-1.00.3
Intermitt. access escalation Index0.82.47.11.1-1.11.51.51.7-1.32.7-1.4-1.51.31.6-1.51.51.71.6-1.4
Intermittent access day 1 total infusions0.10.31.6-1.3-0.70.20.2-0.4-0.4-0.10.60.70.1-0.40.6-0.20.30.30.3
Intermittent access day 15 total infusions0.51.22.8-1.70.2-0.7-0.7-1.30.4-0.61.61.4-1.0-1.31.4-1.2-0.6-0.61.1
Intermittent access terminal intake (last 3 days)0.81.43.4-1.80.2-0.8-0.8-1.50.4-1.21.61.6-1.0-1.41.5-1.3-0.8-0.71.2
Intermittent access total infusions0.91.02.4-1.50.2-0.7-0.7-1.20.4-1.11.51.4-0.8-1.21.2-1.1-0.6-0.61.0
Intermittent access day 1 locomotion0.20.30.6-0.60.4-0.6-0.6-0.60.5-0.20.60.8-0.5-0.70.6-0.7-0.5-0.50.7
Intermittent access day 15 total locomotion1.03.84.7-0.91.9-2.2-2.2-1.92.1-1.81.81.9-2.2-2.01.8-2.1-2.0-2.02.0
Intermittent access total locomotion2.73.33.9-0.91.8-2.0-2.0-1.81.9-1.71.81.8-1.9-1.91.7-2.0-1.9-1.81.8
Intermittent access standard deviation0.52.55.6-1.50.7-1.6-1.6-1.91.2-2.41.91.7-1.6-1.71.7-1.7-1.1-1.01.2
Left kidney weight1.914.923.2-1.83.0-4.8-4.8-3.93.6-4.43.53.6-4.2-3.93.4-4.1-4.2-3.83.7
Right kidney weight2.819.929.6-1.94.1-5.4-5.4-4.44.6-5.03.93.9-4.9-4.43.9-4.7-4.8-4.64.3
Cocaine induced anxiety0.41.13.92.00.10.80.71.2-0.40.6-1.3-1.30.71.2-1.31.00.70.6-1.2
Post-drug Anxiety0.91.02.41.5-0.40.90.91.1-0.50.9-1.1-1.20.81.2-1.21.00.90.8-1.2
Baseline Anxiety0.30.62.0-1.0-1.40.70.80.2-0.91.1-0.0-0.10.70.30.00.51.00.8-0.3
Tail length2.211.726.51.05.1-4.2-4.1-2.54.7-4.31.82.1-4.2-2.71.9-3.2-3.9-3.62.4
Length with tail4.118.041.31.26.4-5.3-5.3-3.15.9-5.22.32.4-5.1-3.32.4-4.0-4.7-4.42.8
Length without tail2.312.222.6-0.04.8-4.3-4.2-2.94.6-3.42.62.4-4.1-3.02.5-3.5-3.8-4.02.8
Times rat made contact with spout1.21.44.6-0.6-2.11.31.30.6-1.91.1-0.5-0.51.50.8-0.51.11.51.2-0.6
Lifetime Intake1.11.32.4-1.50.4-0.9-0.9-1.40.7-1.21.51.5-1.0-1.31.3-1.3-0.8-0.81.1
Liver weight, left0.91.57.32.32.7-1.4-1.30.41.9-0.3-0.7-0.7-1.20.1-0.6-0.3-1.0-0.7-0.1
Liver weight, right2.34.112.21.53.5-2.7-2.6-0.83.0-1.80.50.5-2.3-1.20.5-1.6-2.5-2.21.4
Locomotor activity0.71.24.42.12.0-1.1-1.00.41.4-1.5-0.7-0.7-0.80.1-0.8-0.3-1.0-0.7-0.1
Locomotor testing distance0.30.62.81.70.6-0.00.00.80.0-0.9-1.2-1.10.30.7-1.30.6-0.3-0.1-0.6
Locomotor testing rearing0.10.41.21.11.1-0.6-0.60.00.6-0.8-0.5-0.3-0.5-0.1-0.4-0.3-0.8-0.40.1
Locomotion in novel chamber0.10.20.4-0.10.6-0.5-0.6-0.50.5-0.50.50.2-0.5-0.40.4-0.6-0.2-0.20.3
Locomotion in novel chamber post-restriction0.30.91.7-0.80.4-1.1-1.1-1.00.8-1.30.81.0-0.9-1.01.0-0.9-0.8-1.30.9
Fecal boli incidents, locomotor time 10.51.22.20.5-1.01.51.51.0-1.30.7-1.0-1.01.41.0-1.01.31.10.8-1.1
Change in fecal boli incidents, locomotor task1.21.32.2-0.41.1-1.2-1.2-1.01.5-0.61.00.9-1.3-1.11.0-1.3-1.4-1.41.2
Time >=10cm from walls, locomotor time 10.40.52.10.71.4-0.8-0.8-0.11.1-0.3-0.10.2-0.7-0.4-0.0-0.4-1.1-1.00.5
Bouts of movement, locomotor time 10.60.71.41.20.00.80.81.0-0.4-0.2-1.0-0.90.81.0-1.00.90.60.9-1.1
Total resting periods, locomotor time 10.20.30.91.00.40.50.50.60.0-0.3-0.6-0.60.30.5-0.60.50.20.4-0.7
Rest time, locomotor task time 10.30.52.20.71.5-0.6-0.6-0.21.1-0.20.20.2-1.0-0.40.2-0.6-0.8-0.90.4
Distance moved, locomotor task time 10.00.10.7-0.7-0.5-0.5-0.4-0.4-0.1-0.90.10.4-0.0-0.30.2-0.0-0.1-0.00.2
Vertical activity count, locomotor time 10.00.10.6-0.4-0.5-0.4-0.4-0.1-0.1-0.7-0.20.10.4-0.0-0.00.10.10.4-0.0
Time >=10cm from walls, locomotor time 20.20.51.20.31.1-0.8-0.8-0.41.0-0.80.30.2-0.4-0.40.4-0.6-0.9-0.90.4
Bouts of movement, locomotor time 20.30.93.80.91.9-1.1-1.1-0.41.4-0.80.50.3-1.3-0.50.3-0.9-0.8-0.70.3
Total resting periods, locomotor time 20.20.84.11.42.0-1.0-1.0-0.11.4-0.60.2-0.1-1.2-0.2-0.0-0.7-0.6-0.5-0.0
Rest time, locomotor task time 20.71.26.32.51.50.20.21.30.60.8-1.3-1.3-0.01.0-1.40.70.10.2-0.9
Distance moved, locomotor task time 21.11.44.3-2.1-0.6-1.2-1.2-1.5-0.0-1.31.31.4-0.5-1.21.5-1.1-0.6-0.61.1
Vertical activity count, locomotor time 20.10.20.9-1.0-0.7-0.6-0.6-0.5-0.2-0.40.40.50.2-0.30.6-0.30.00.20.4
Light reinforcement 10.00.10.7-0.8-0.50.10.2-0.5-0.2-0.30.40.4-0.1-0.40.5-0.20.1-0.20.3
Light reinforcement 21.12.54.6-0.41.9-1.5-1.4-1.42.0-1.91.31.3-1.9-1.51.4-1.5-1.7-2.11.3
Bone: marrow area1.43.312.02.13.5-2.2-2.1-0.42.8-1.7-0.00.0-2.1-0.8-0.1-1.2-2.3-2.20.7
Bone: maximum diameter0.40.84.82.21.5-0.4-0.30.81.0-0.3-1.1-1.0-0.30.6-1.10.3-0.3-0.1-0.6
Bone: maximum force2.03.97.0-1.31.4-2.6-2.6-2.21.8-1.61.91.9-2.0-2.01.8-2.1-2.1-1.72.3
Bone: maximum moment1.73.15.8-1.01.4-2.4-2.3-1.91.7-1.81.61.6-1.8-1.81.6-1.8-1.8-1.51.9
Mean time between licks in bursts0.21.15.22.31.90.00.01.11.0-0.1-1.2-1.3-0.20.8-1.20.5-0.1-0.4-0.9
Mean num. licks in bursts0.20.62.7-1.2-1.70.30.3-0.2-1.20.60.20.30.80.10.30.31.01.1-0.1
Cd content in liver0.20.20.9-0.8-1.0-0.1-0.2-0.4-0.5-0.50.20.20.2-0.20.2-0.00.10.20.3
Co content in liver0.70.92.8-1.7-0.8-0.5-0.5-1.3-0.1-0.81.21.2-0.5-1.01.2-0.8-0.5-0.51.1
Cu content in liver1.11.35.0-1.1-2.21.61.50.2-1.70.6-0.1-0.11.20.4-0.10.81.21.5-0.5
Fe content in liver1.01.22.4-1.6-0.4-1.0-1.0-1.30.2-0.61.31.3-0.8-1.21.3-1.1-0.8-1.11.5
K content in liver0.60.61.4-0.0-0.71.21.10.7-0.90.6-0.6-0.61.00.7-0.60.90.91.0-0.7
Mg content in liver1.01.11.71.3-0.31.31.31.3-0.60.5-1.3-1.30.91.2-1.31.20.70.9-1.1
Mn content in liver3.13.58.62.90.31.71.72.4-0.61.2-2.4-2.41.32.1-2.41.91.31.1-2.2
Na content in liver0.40.41.6-1.3-0.8-0.4-0.5-0.7-0.4-0.60.70.7-0.1-0.60.7-0.4-0.20.00.8
Rb content in liver0.50.61.30.1-1.11.11.00.5-1.00.3-0.5-0.50.80.6-0.50.70.81.1-0.5
Se content in liver0.50.63.51.91.1-0.3-0.20.70.7-0.4-0.9-0.9-0.20.6-0.90.3-0.2-0.4-0.7
Sr content in liver0.50.41.30.31.1-0.8-0.8-0.41.1-0.50.40.4-0.8-0.50.4-0.7-0.6-0.50.5
Zn content in liver0.30.30.60.7-0.30.40.40.6-0.4-0.0-0.8-0.70.60.7-0.80.60.50.6-0.6
Bone: minimum diameter0.61.15.72.42.1-0.6-0.50.81.4-0.4-1.1-1.0-0.40.6-1.10.2-0.5-0.5-0.5
Time in familiar zone, hab. session 11.61.84.7-0.8-2.21.81.80.6-2.01.5-0.5-0.51.50.8-0.31.21.41.6-0.7
Time in novel zone, hab. session 11.11.34.30.91.7-1.4-1.4-0.61.6-2.10.30.3-1.2-0.60.2-0.9-1.0-1.30.1
Total zone transitions, hab. session 10.91.31.90.5-1.01.41.41.1-1.20.9-1.0-1.01.31.2-1.11.31.21.2-1.1
Total locomotion distance, hab. session 10.50.81.10.1-0.91.01.00.8-1.01.0-0.6-0.61.00.8-0.70.90.91.0-0.9
Locomotion velocity, hab. session 10.30.40.9-0.2-0.80.80.80.5-0.81.0-0.3-0.30.90.5-0.40.60.70.9-0.5
Time in familiar zone, hab. session 20.50.51.6-0.2-1.10.60.50.5-1.11.3-0.4-0.30.60.6-0.20.60.91.2-0.4
Time in novel zone, hab. session 20.60.72.4-0.30.8-0.7-0.6-0.81.0-1.60.70.7-0.7-0.80.6-0.8-0.9-1.30.6
Total zone transitions, hab. session 20.10.10.6-0.4-0.80.10.1-0.1-0.50.30.10.10.40.10.00.10.30.30.0
Total locomotion distance, hab. session 20.91.22.60.0-1.61.11.10.8-1.51.1-0.8-0.81.31.0-0.81.11.21.1-0.9
Locomotion velocity, hab. session 21.01.42.50.2-1.61.11.11.0-1.61.2-0.9-0.91.51.1-1.01.21.31.4-1.0
Novel to familiar place preference ratio0.20.20.6-0.7-0.20.10.1-0.60.2-0.60.70.6-0.1-0.50.5-0.3-0.4-0.60.3
Novelty place preference0.30.40.8-0.70.1-0.2-0.2-0.80.5-0.90.80.8-0.4-0.70.6-0.6-0.6-0.90.5
Time in novel zone, NPP test0.50.61.2-0.70.4-0.4-0.4-1.00.7-1.10.90.9-0.7-0.90.7-0.7-0.8-1.10.6
Total zone transitions, NPP test1.01.52.10.6-1.11.41.41.1-1.30.7-1.2-1.21.41.3-1.21.41.21.2-1.3
Total locomotion distance, NPP test0.81.12.1-0.1-1.41.31.30.7-1.40.7-0.6-0.71.40.9-0.71.11.11.1-1.0
Locomotion velocity, NPP test1.52.23.80.1-1.81.81.81.2-1.91.3-1.0-1.01.91.3-1.11.51.61.6-1.4
Intraocular pressure0.40.71.30.5-0.80.60.60.9-0.90.3-1.0-0.70.80.9-0.80.91.20.9-0.9
Delta distance traveled before/after self-admin1.51.73.2-1.00.9-1.3-1.3-1.41.0-1.11.31.3-1.1-1.41.2-1.2-1.8-1.81.5
Delta ambulatory time before/after self-admin0.61.12.4-0.61.0-1.0-1.0-1.01.0-0.80.91.0-1.0-1.00.8-1.0-1.4-1.61.2
Parametrial fat weight0.92.12.7-0.81.4-1.5-1.5-1.61.6-1.31.51.4-1.6-1.51.4-1.6-1.5-1.31.5
Pavlov. Cond. lever latency1.21.56.0-2.4-1.1-0.6-0.6-1.6-0.3-0.51.61.6-0.6-1.31.8-1.0-0.2-0.01.3
Pavlov. Cond. magazine entry latency2.32.97.52.70.41.11.02.3-0.41.5-2.2-2.21.22.0-2.31.61.21.2-1.8
Pavlov. Cond. change in total contacts0.60.62.91.21.7-0.6-0.70.11.3-0.5-0.2-0.2-0.6-0.1-0.3-0.3-0.9-1.00.1
Pavlov. Cond. index score2.22.88.73.00.81.00.92.3-0.11.5-2.2-2.21.01.9-2.31.50.80.7-1.7
Pavlov. Cond. latency score1.82.38.12.81.00.80.72.00.21.1-2.0-2.00.81.7-2.11.30.60.5-1.5
Pavlov. Cond. lever contacts1.11.35.72.41.30.50.41.50.50.4-1.5-1.50.51.2-1.70.90.1-0.0-1.1
Pavlov. Cond. magazine entry number2.63.46.5-2.60.1-1.4-1.3-2.40.8-1.92.32.2-1.5-2.12.4-1.8-1.4-1.41.9
Pavlov. Cond. intertrial magazine entries0.50.62.3-1.5-1.50.40.4-0.7-1.00.00.70.70.4-0.30.7-0.00.70.60.2
Pavlov. Cond. lever-magazine prob. diff.2.53.18.62.90.61.21.12.3-0.31.7-2.3-2.31.22.0-2.41.70.90.9-1.8
Pavlov. Cond. response bias2.32.97.92.80.51.21.22.3-0.31.6-2.2-2.21.22.0-2.41.71.00.8-1.8
Pavlov. Cond. lever latency0.30.41.0-0.10.7-0.5-0.5-0.50.80.10.40.4-0.8-0.60.5-0.7-0.9-1.00.8
Pavlov. Cond. magazine entry latency0.20.31.50.31.2-0.6-0.6-0.20.9-0.50.20.3-0.6-0.30.2-0.4-0.5-0.50.2
Pavlov. Cond. change in total contacts0.10.20.8-0.50.1-0.5-0.5-0.50.3-0.90.50.5-0.4-0.40.5-0.4-0.3-0.30.4
Pavlov. Cond. index score0.00.10.30.30.5-0.1-0.10.20.2-0.5-0.1-0.10.00.2-0.20.10.10.1-0.3
Pavlov. Cond. latency score0.00.00.30.00.4-0.2-0.20.00.3-0.50.00.1-0.10.00.0-0.00.10.1-0.2
Pavlov. Cond. lever contacts0.10.20.6-0.0-0.50.30.30.3-0.5-0.3-0.3-0.30.60.4-0.30.50.60.8-0.6
Pavlov. Cond. magazine entry number0.30.40.90.2-0.90.80.80.5-0.81.0-0.5-0.50.60.5-0.40.50.60.6-0.4
Pavlov. Cond. intertrial magazine entries0.51.12.71.60.10.90.91.3-0.31.0-1.3-1.40.71.2-1.31.00.90.7-1.2
Pavlov. Cond. lever-magazine prob. diff.0.00.10.30.30.4-0.1-0.10.20.1-0.5-0.2-0.10.10.2-0.30.20.20.2-0.4
Pavlov. Cond. response bias0.10.20.50.50.10.30.30.5-0.2-0.4-0.5-0.40.40.5-0.50.50.40.4-0.7
Time in closed arm before self-admin0.00.00.2-0.2-0.00.40.40.00.00.50.10.00.0-0.10.2-0.00.00.10.1
Time in closed arm after self-admin1.82.03.9-2.00.1-1.1-1.1-1.70.9-0.91.71.7-1.2-1.61.8-1.5-1.2-1.21.7
Time in open arm before self-admin0.40.51.00.9-0.10.40.40.9-0.11.0-1.0-1.00.40.8-1.00.80.70.6-0.7
Time in open arm after self-admin0.91.02.51.60.20.60.61.2-0.30.7-1.1-1.30.71.2-1.41.01.01.2-1.3
Bone: periosteal estimation1.33.18.61.12.9-2.2-2.1-1.02.6-1.80.60.7-2.1-1.20.6-1.5-2.2-2.01.1
Bone: periosteal perimeter0.51.04.51.42.1-1.1-1.0-0.11.7-0.9-0.2-0.1-1.0-0.2-0.2-0.5-1.1-0.80.2
Bone: post-yield work0.81.46.22.51.3-0.1-0.11.30.60.1-1.6-1.70.41.2-1.70.90.40.5-1.3
Progressive ratio test 1 active lever presses0.40.72.2-1.5-0.0-0.5-0.5-1.00.4-0.21.31.2-0.6-1.01.1-1.0-0.5-0.41.0
Progressive ratio test 1 breakpoint0.50.82.2-1.50.0-0.5-0.6-1.00.4-0.31.31.2-0.7-1.01.1-1.0-0.5-0.41.0
Progressive ratio test 1 inactive lever presses0.20.52.9-1.7-1.00.10.1-0.7-0.3-0.41.00.80.0-0.50.8-0.40.40.30.4
Progressive ratio test 2 active lever presses0.30.42.1-1.4-0.4-0.1-0.1-0.6-0.30.20.90.8-0.2-0.60.8-0.60.20.20.5
Progressive ratio test 2 breakpoint0.30.42.3-1.5-0.4-0.2-0.2-0.7-0.20.21.00.9-0.3-0.60.9-0.60.10.10.6
Progressive ratio test 2 inactive lever presses0.10.40.6-0.60.5-0.5-0.6-0.60.7-0.60.80.7-0.7-0.70.7-0.7-0.4-0.40.5
Incentive Sensitization - Responses0.10.31.2-0.4-0.60.60.60.4-0.71.1-0.2-0.30.60.4-0.10.41.00.8-0.4
Incentive Sensitization - Breakpoint0.10.31.1-0.4-0.60.60.50.4-0.71.1-0.1-0.20.50.4-0.10.31.00.8-0.4
Sum of active levers in priming session hrs 5-60.30.20.50.4-0.30.40.40.6-0.50.5-0.7-0.60.40.6-0.50.50.30.4-0.5
Progressive ratio2.16.27.8-2.01.6-2.7-2.7-2.82.2-1.62.72.5-2.7-2.72.7-2.8-2.3-2.52.7
Food seeking constrained by brief footshock0.00.00.1-0.0-0.30.20.20.0-0.20.1-0.0-0.3-0.10.10.00.10.10.2-0.1
Seeking ratio, punishment vs. effort2.04.65.81.6-1.62.42.42.3-2.01.1-2.3-2.22.32.3-2.32.42.02.2-2.4
Retroperitoneal fat weight0.62.73.9-1.01.3-2.0-2.0-1.81.6-1.81.81.5-1.6-1.71.4-1.8-1.7-1.51.6
Reaction time number correct0.20.93.5-1.9-0.6-0.2-0.3-1.2-0.1-0.61.31.3-0.4-1.11.1-0.7-0.5-0.61.0
Reaction time mean minus median0.31.68.83.02.1-0.6-0.61.31.20.1-1.5-1.6-0.31.0-1.40.4-0.1-0.1-1.0
Reaction time mean minus median AUC0.21.26.12.51.7-0.6-0.61.01.1-0.3-1.2-1.4-0.10.9-1.20.3-0.1-0.0-0.8
Reaction time num false alarms0.10.10.40.50.7-0.1-0.10.30.4-0.0-0.4-0.2-0.10.1-0.30.1-0.5-0.40.1
Reaction time num false alarms AUC0.10.10.60.60.8-0.3-0.30.30.4-0.2-0.4-0.3-0.00.1-0.30.1-0.5-0.40.1
Reaction time trials correct on left0.20.93.5-1.9-0.6-0.2-0.3-1.2-0.1-0.61.31.3-0.4-1.11.1-0.7-0.5-0.61.0
Reaction time trials on left0.20.83.2-1.8-0.5-0.3-0.3-1.2-0.0-0.71.21.2-0.5-1.11.1-0.8-0.5-0.71.0
Reaction time mean1.12.511.23.31.50.30.32.00.40.3-2.3-2.10.51.7-2.11.30.40.5-1.7
Reaction time mean AUC0.92.210.63.31.60.10.11.90.60.1-2.1-2.00.31.5-1.91.10.30.3-1.6
Median of all reaction times1.21.97.82.81.10.50.51.90.10.3-2.0-1.80.61.5-1.81.30.40.5-1.5
Reaction time omissions0.61.05.92.41.3-0.1-0.11.20.60.4-1.3-1.4-0.20.9-1.20.50.0-0.4-0.8
Reaction time false alarm rate0.40.62.61.61.0-0.1-0.10.90.50.1-1.1-1.00.20.7-1.00.5-0.20.0-0.6
Reaction time premature initiation rate0.60.91.7-0.60.9-1.3-1.3-0.90.9-1.10.80.7-0.8-0.90.9-1.1-0.9-1.01.0
Reaction time premature initiations0.72.02.8-1.60.5-1.4-1.4-1.60.9-1.41.51.5-1.0-1.61.6-1.5-1.2-1.51.7
Std. dev. reaction times0.51.89.63.12.3-0.7-0.71.31.2-0.2-1.5-1.5-0.31.0-1.50.4-0.3-0.2-1.0
Reaction time trials completed0.20.83.2-1.8-0.5-0.3-0.3-1.2-0.0-0.71.21.2-0.5-1.11.1-0.8-0.5-0.71.0
Reaction time trials AUC0.20.83.2-1.8-0.6-0.2-0.2-1.1-0.1-0.61.11.2-0.4-1.01.1-0.7-0.4-0.61.0
Run reversals in cocaine runway, females0.20.31.1-0.4-1.00.70.70.1-0.7-0.1-0.1-0.10.50.3-0.00.40.50.8-0.4
Run reversals in cocaine runway, males1.01.14.81.42.2-1.0-1.0-0.11.7-1.0-0.3-0.1-1.1-0.3-0.1-0.6-1.2-1.30.2
Latency to leave start box in cocaine runway0.00.00.10.0-0.20.10.10.1-0.10.3-0.0-0.0-0.00.0-0.10.0-0.0-0.30.1
Latency to leave start box in cocaine runway, F0.60.71.10.8-0.60.91.01.0-0.70.6-0.8-0.90.90.9-0.90.91.00.6-1.0
Latency to leave start box in cocaine runway, M2.12.03.3-1.10.9-1.4-1.4-1.41.2-0.71.41.4-1.5-1.61.4-1.5-1.6-1.61.8
Std. dev. time between licks in bursts0.51.04.82.21.8-0.4-0.40.91.1-0.1-1.1-1.1-0.40.7-1.10.2-0.2-0.3-0.8
Total sessions with >9 infusions0.70.91.7-1.30.3-0.7-0.7-1.10.7-0.71.31.3-0.7-1.11.0-1.0-0.8-0.71.1
Short access day 1 total inactive lever presses0.61.23.50.31.9-1.4-1.4-0.71.8-1.10.70.7-1.3-0.80.7-1.0-1.0-1.00.7
Short access day 10 total inactive lever presses0.32.43.01.5-1.01.31.31.7-1.11.6-1.6-1.71.51.7-1.71.71.71.7-1.7
Short access day 1 total infusions0.00.10.3-0.5-0.2-0.0-0.0-0.20.1-0.40.30.40.1-0.20.2-0.1-0.00.10.1
Short access day 10 total infusions0.40.61.5-1.2-0.0-0.5-0.5-0.90.5-0.81.01.1-0.4-0.90.8-0.8-0.7-0.60.9
Short access total infusions0.71.02.0-1.40.1-0.7-0.7-1.20.6-1.11.31.4-0.7-1.11.1-1.0-0.8-0.71.0
Short access day 1 locomotion0.40.61.40.1-0.90.90.90.7-0.70.6-0.4-0.61.20.8-0.90.80.70.8-0.7
Short access day 10 total locomotion0.20.61.80.51.3-0.9-0.9-0.41.3-1.10.30.3-0.8-0.50.2-0.7-0.9-0.90.5
Short access total locomotion0.10.20.6-0.10.6-0.4-0.4-0.30.8-0.50.40.4-0.4-0.40.2-0.4-0.6-0.50.5
One hour access (0.3 mA shock)0.91.12.30.2-0.91.21.21.0-1.21.0-0.7-0.91.11.0-0.80.91.51.5-1.1
Compulsive drug intake4.05.910.02.4-1.12.42.42.9-1.83.2-2.9-2.82.32.7-2.52.62.02.1-2.2
One hour access (shock baseline)0.51.43.5-1.30.6-1.1-1.1-1.50.7-1.91.61.4-1.2-1.21.3-1.4-0.5-0.60.8
Social response proportion0.10.10.40.70.6-0.1-0.10.20.1-0.3-0.2-0.3-0.00.2-0.30.0-0.10.2-0.4
Social responses0.20.20.5-0.20.5-0.6-0.6-0.60.4-0.50.50.3-0.7-0.50.5-0.6-0.4-0.20.4
Social time0.91.46.42.51.9-0.3-0.31.30.91.2-1.2-1.5-0.11.0-1.30.50.00.5-0.9
Soleus weight0.82.211.93.52.2-0.4-0.41.51.0-0.5-1.9-2.00.01.3-1.90.8-0.4-0.4-1.1
Bone: stiffness0.40.71.4-1.00.1-1.2-1.2-1.00.40.20.90.9-0.5-0.80.9-0.8-0.6-0.41.1
Tibialis anterior weight0.10.42.3-1.4-1.50.00.0-0.5-1.0-0.60.40.40.5-0.30.50.00.10.00.6
Time to tail flick, vehicle, before self-admin0.91.13.31.2-0.30.80.81.4-0.61.8-1.1-1.30.81.2-1.11.00.71.1-0.9
Time to tail flick, vehicle, after self-admin0.40.82.51.1-0.00.70.71.1-0.41.6-1.1-1.00.50.9-0.90.90.80.9-0.9
Time to tail flick, test, before self-admin0.00.10.2-0.30.00.00.0-0.20.10.30.20.2-0.4-0.20.4-0.30.30.20.1
Time to tail flick, test, after self-admin0.20.20.50.70.50.00.00.50.60.6-0.4-0.6-0.20.4-0.20.20.20.5-0.4
Delta time to tail flick, vehicle, before/after SA0.10.10.3-0.6-0.40.10.1-0.3-0.2-0.20.10.2-0.0-0.20.30.00.2-0.10.1
Delta time to tail flick, test, before/after SA0.30.30.50.1-0.70.60.60.5-0.60.7-0.4-0.60.70.6-0.50.70.40.6-0.5
Tibia length1.43.910.81.13.3-2.4-2.4-1.23.0-1.60.80.8-2.3-1.40.8-1.8-2.5-2.41.5
Ambulatory time before self-admin0.00.10.50.70.7-0.1-0.10.30.30.1-0.1-0.4-0.10.2-0.2-0.10.10.6-0.4
Ambulatory time after self-admin0.30.42.00.51.4-0.8-0.8-0.30.9-0.10.30.2-0.7-0.30.3-0.6-0.8-0.60.4
Bone: tissue strength0.80.91.3-0.70.8-1.1-1.1-1.00.9-0.80.91.0-0.9-1.01.0-1.0-0.7-0.71.0
Total heroin consumption0.20.20.50.70.40.00.00.5-0.00.5-0.5-0.60.10.5-0.30.20.60.4-0.7
Bone: trabecular number0.71.43.3-0.5-1.81.71.70.7-1.71.0-0.5-0.61.50.8-0.61.21.11.2-0.7
Bone: trabecular spacing2.63.76.4-0.32.3-2.3-2.3-1.62.5-1.81.51.5-2.4-1.81.5-2.1-2.2-2.11.6
Bone: trabecular thickness1.01.42.40.1-1.31.31.31.0-1.60.8-1.0-1.01.51.1-0.91.31.31.4-1.0
Bone: trabecular tissue density1.32.33.9-1.01.2-2.0-1.9-1.51.4-1.81.41.4-1.5-1.51.4-1.6-1.5-1.31.6
Water consumed over 24 hours0.00.00.10.40.3-0.0-0.00.10.20.1-0.1-0.1-0.20.0-0.1-0.0-0.2-0.40.0
Number of responses in last shaping day0.30.41.6-0.20.6-0.5-0.6-0.70.7-1.20.70.6-0.4-0.60.2-0.4-1.0-0.90.5