Hub : Genes

Gulp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	Gulp1	0.06	0.05	6.5e-06	0.06	0.05	0.06	0.06	5.7e-06	1.6e-05	2.2e-06	4.8e-06
2	Brain	intron excision ratio	chr9_46884963_46897134	0.03	0.03	8.8e-03	0.01	0.01	-0	0	7.7e-02	3.7e-02	3.7e-01	2.8e-01
3	Adipose	gene expression	Gulp1	0.05	0.04	6.9e-06	0.03	0.03	0.03	0.03	2.4e-04	4.1e-04	6.0e-04	5.5e-04
4	NAcc	gene expression	Gulp1	0.4	0.15	0.0e+00	0.27	0.27	0.28	0.28	3.0e-31	8.1e-32	4.9e-32	3.0e-32

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	3.8	6.4	10.2	-3.2	2.3	-2.7	1.6
Area under the delay curve	0.8	0.9	2.8	0.6	0.2	0.5	-1.7
BMI with tail	2.8	8.9	13.5	3.7	-3.3	3.4	-0.4
BMI without tail	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.0
Body weight	0.1	0.5	0.5	0.7	-0.6	0.7	-0.7
Weight adjusted by age	1.8	2.0	3.7	0.7	-1.9	0.7	1.8
Bone surface	0.5	0.9	2.8	-0.7	-0.2	-0.5	1.7
Bone volume	1.5	2.6	3.9	-2.0	1.0	-1.6	1.7
Breakpoint value in progressive ratio session	0.3	0.3	0.6	-0.6	0.8	-0.5	-0.2
Number of licking bursts	0.3	0.4	0.7	-0.8	0.6	-0.7	0.3
Context. condit. distance diff. score	1.3	1.6	2.7	-1.4	1.6	-1.1	-0.8
Locomotion velocity, session 1	0.6	0.7	2.3	0.2	0.6	0.2	-1.5
Locomotion distance, session 1	1.2	1.5	2.2	1.5	-0.4	1.2	-1.5
Locomotion velocity, session 2	3.8	4.4	6.7	2.6	-2.4	2.3	0.1
Locomotion distance, session 2	3.6	5.1	8.5	2.9	-2.2	2.6	-0.4
Locomotion velocity, session 3	0.1	0.2	0.3	-0.4	0.5	-0.5	0.0
Locomotion distance, session 3	0.1	0.1	0.2	-0.4	0.3	-0.4	0.1
Stereotopy head waving bouts, day 3	0.3	0.4	0.5	-0.7	0.7	-0.6	-0.0
Stereotopy head waving duration, day 3	0.4	0.4	0.8	-0.4	0.9	-0.3	-0.8
Locomotion velocity, session 7	0.7	0.8	1.2	0.7	-1.1	0.7	0.9
Locomotion distance, session 7	0.9	1.1	1.6	1.2	-1.2	1.1	0.2
Stereotopy head waving bouts, day 7	0.3	0.3	0.5	-0.5	0.7	-0.4	-0.5
Stereotopy head waving duration, day 7	0.5	0.6	0.9	-0.7	1.0	-0.7	-0.7
Locomotion velocity, session 8	0.1	0.1	0.1	0.2	-0.3	0.2	0.4
Locomotion distance, session 8	0.7	1.0	1.5	1.2	-0.9	1.2	-0.3
Degree of sensitization distance	1.4	1.4	2.1	1.5	-1.2	1.4	-0.5
Degree of sensitization stereotypy	0.1	0.1	0.1	-0.3	0.3	-0.4	-0.1
Conditioned locomotion	0.4	0.5	1.6	-0.2	0.7	-0.1	-1.3
Cocaine response after cond. corrected	0.7	0.8	1.2	1.0	-0.5	0.8	-1.1
Cocaine response after cond. not corrected	0.7	0.7	1.3	0.9	-0.4	0.8	-1.2
Cocaine response before conditioning	0.0	0.0	0.0	-0.0	0.1	-0.0	0.0
Saline control response	0.1	0.2	0.2	0.4	-0.3	0.4	-0.5
Bone: connectivity density	0.9	1.4	2.0	-1.3	0.6	-1.1	1.4
Bone: cortical apparent density	2.1	2.8	4.6	1.8	-2.1	1.7	0.5
Bone: cortical area	0.3	0.4	0.6	0.6	-0.8	0.7	0.2
Bone: cortical porosity	1.3	1.4	2.3	-1.5	1.1	-1.4	0.5
Bone: cortical porosity	1.6	1.8	2.7	-1.7	1.4	-1.5	0.3
Bone: cortical thickness	0.3	0.5	0.7	0.7	-0.8	0.8	-0.1
Bone: cortical thickness	0.1	0.2	0.3	0.4	-0.4	0.5	-0.1
Bone: cortical tissue density	2.0	2.7	4.4	1.8	-2.1	1.6	0.6
Condit. Reinf. active minus inactive responses	2.3	2.5	8.2	0.4	1.3	0.5	-2.9
Condit. Reinf. active-inactive response ratio	3.1	3.3	10.5	0.0	1.7	0.2	-3.2
Condit. Reinf. active responses	1.2	1.4	4.5	0.4	1.0	0.4	-2.1
Condit. Reinf. inactive responses	0.4	0.4	0.9	0.9	-0.6	0.7	-0.3
Incentive salience index mean	1.0	1.2	3.4	0.0	1.2	0.1	-1.8
Condit. Reinf. lever presses	0.5	0.7	1.5	-0.8	1.2	-0.6	-0.5
Condit. Reinf. active minus inactive responses	0.9	1.1	2.0	-0.7	1.4	-0.6	-1.3
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.7	-1.2	1.7	-1.1	-0.7
Condit. Reinf. active responses	0.3	0.4	1.1	0.4	0.2	0.5	-1.1
Condit. Reinf. inactive responses	0.9	1.1	1.7	1.1	-1.3	1.2	0.1
Condit. Reinf. lever presses	0.2	0.3	0.5	-0.7	0.7	-0.5	-0.1
Condit. Reinf. lever reinforcers received	0.4	0.5	1.4	0.6	0.1	0.6	-1.2
Conditioned reinforcement - actives	0.2	0.2	0.5	-0.3	0.7	0.2	-0.7
Conditioned reinforcement - inactives	0.6	0.7	1.1	-0.7	1.1	-0.4	-0.9
Conditioned locomotion	1.3	1.5	2.7	1.3	-1.3	1.6	-0.1
Patch foraging indifference point 0 sec	1.8	2.8	7.6	0.2	-1.9	0.2	2.7
Patch foraging indifference point AUC	1.1	1.3	2.2	1.5	-1.2	1.2	-0.1
Delay disc. indifference point, 0s delay	0.1	0.1	0.4	0.3	-0.7	0.0	0.3
Delay disc. indifference point, 16s delay	0.7	0.7	2.0	-0.1	0.9	0.1	-1.4
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	0.4	-0.5	0.1	-0.2
Delay disc. indifference point, 24s delay	0.9	0.9	1.3	-0.6	1.1	-0.6	-1.2
Delay disc. indifference point, 4s delay	0.7	0.7	1.5	0.9	-0.3	0.8	-1.2
Delay disc. indifference point, 8s delay	0.2	0.2	0.8	0.2	0.2	0.1	-0.9
Indifference point function ln k	0.2	0.2	0.7	0.3	-0.8	0.4	0.3
Indifference point function log k	0.2	0.2	0.7	0.3	-0.8	0.4	0.3
Patch foraging total patch changes 0 sec	2.0	3.3	7.3	0.6	-2.3	0.5	2.7
Patch foraging total patch changes 12 sec	0.8	1.0	3.2	0.2	-0.9	0.1	1.8
Patch foraging total patch changes 18 sec	2.1	2.7	4.9	1.5	-2.2	1.3	1.4
Patch foraging total patch changes 24 sec	0.8	1.0	2.4	0.3	-1.2	0.2	1.5
Patch foraging total patch changes 6 sec	1.3	1.9	5.9	-0.0	-1.3	-0.0	2.4
Patch foraging time to switch 0 sec	0.5	0.8	1.2	-1.0	1.1	-0.9	0.2
Patch foraging water rate 0 sec	0.5	0.8	1.3	1.0	-1.1	0.9	-0.4
Patch foraging water rate 12 sec	0.7	1.0	2.7	0.0	-1.2	0.0	1.6
Patch foraging water rate 18 sec	0.6	0.8	1.2	-1.1	0.5	-1.0	0.9
Patch foraging water rate 24 sec	0.0	0.0	0.0	-0.1	0.1	0.1	-0.2
Patch foraging water rate 6 sec	0.3	0.4	1.2	-0.0	-0.8	0.1	1.1
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.3	-0.2	0.6	-0.3	-0.4
Distance traveled before self-admin	0.1	0.1	0.5	-0.2	-0.0	-0.1	0.7
Distance traveled after self-admin	2.3	2.6	3.8	-1.9	1.0	-1.7	1.6
Extensor digitorum longus weight	5.2	20.5	32.2	5.7	-5.0	4.9	-0.9
Bone: elastic displacement	0.5	0.6	1.4	-0.8	0.2	-0.6	1.2
Bone: elastic work	0.2	0.3	0.5	-0.7	0.6	-0.5	0.3
Bone: endosteal estimation	0.0	0.0	0.0	-0.1	0.1	-0.1	0.2
Bone: endosteal perimeter	0.0	0.0	0.0	0.1	0.1	0.2	-0.2
Epididymis fat weight	0.0	0.1	0.3	-0.0	-0.2	-0.1	0.6
Delta time in closed arm before/after self-admin	1.6	1.5	4.2	-1.0	-0.0	-1.0	2.0
Delta time in open arm before/after self-admin	0.2	0.2	0.2	-0.2	0.5	-0.4	-0.5
Diff in mean of infusions in LGA sessions	1.1	1.2	1.8	-1.3	1.0	-1.3	0.5
Delay discount exponential model param	0.9	0.9	3.2	-0.5	-0.4	-0.4	1.8
Extinction: sum of active levers before priming	0.1	0.1	0.3	0.2	0.2	0.2	-0.5
Active lever presses in extinction session 6	1.6	1.5	3.0	1.4	-0.4	1.0	-1.7
Bone: final force	0.1	0.2	0.3	0.4	-0.3	0.4	-0.5
Bone: final moment	0.1	0.2	0.2	0.5	-0.4	0.5	-0.4
Food consumed during 24 hour testing period	0.6	0.7	1.1	1.0	-0.7	0.9	-0.6
Glucose	0.1	0.1	0.2	-0.1	0.4	-0.2	-0.4
Heart weight	0.4	0.5	0.9	0.7	-0.9	0.7	0.5
Delay discount hyperbolic model param	0.9	1.0	3.0	-0.7	-0.1	-0.6	1.7
Intermittent access intake day 1-15 change	0.5	0.5	0.8	-0.8	0.9	-0.7	-0.2
Intermittent access intake escalation	1.4	1.4	2.3	-1.2	1.5	-1.1	-0.8
Intermittent access intake escalation 2	2.0	2.0	3.8	-1.4	1.9	-1.2	-0.9
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.2	0.3	-0.2	0.0
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.5	-0.6	0.5	-0.2	0.7
Intermitt. access escalation Index	1.0	0.9	2.4	-0.3	1.1	-0.1	-1.6
Intermittent access day 1 total infusions	0.2	0.2	0.5	0.2	0.2	0.5	-0.7
Intermittent access day 15 total infusions	1.1	1.2	2.3	-1.1	1.5	-0.7	-1.0
Intermittent access terminal intake (last 3 days)	0.4	0.4	0.8	-0.5	0.9	0.0	-0.8
Intermittent access total infusions	0.3	0.4	0.7	-0.5	0.8	-0.1	-0.7
Intermittent access day 1 locomotion	0.1	0.1	0.4	0.2	-0.2	0.6	-0.0
Intermittent access day 15 total locomotion	0.1	0.1	0.2	0.0	0.2	0.2	-0.4
Intermittent access total locomotion	0.1	0.1	0.4	0.3	-0.1	0.6	-0.3
Intermittent access standard deviation	0.5	0.5	1.0	-0.9	1.0	-0.5	-0.3
Left kidney weight	0.2	0.5	1.5	-0.5	-0.3	-0.4	1.2
Right kidney weight	0.2	0.6	1.8	-0.3	-0.5	-0.2	1.3
Cocaine induced anxiety	0.9	1.0	1.6	1.3	-1.2	1.1	-0.2
Post-drug Anxiety	2.1	2.3	3.4	1.8	-1.0	1.6	-1.5
Baseline Anxiety	0.6	0.7	2.1	0.0	0.8	0.1	-1.4
Tail length	1.7	5.0	7.3	-2.5	2.7	-2.3	-1.0
Length with tail	0.5	1.8	2.6	-1.6	1.5	-1.4	-0.6
Length without tail	1.0	2.2	3.0	1.7	-1.7	1.6	-0.1
Times rat made contact with spout	0.6	0.7	1.2	-0.8	1.1	-0.7	-0.5
Lifetime Intake	0.2	0.2	0.5	-0.1	0.4	0.3	-0.7
Liver weight, left	1.2	1.9	6.2	-0.7	-0.6	-0.7	2.5
Liver weight, right	0.2	0.4	0.6	-0.8	0.3	-0.7	0.6
Locomotor activity	0.1	0.2	0.2	-0.5	0.3	-0.4	0.4
Locomotor testing distance	1.1	1.8	2.6	-1.6	1.0	-1.4	1.2
Locomotor testing rearing	1.8	2.8	4.2	-2.1	2.0	-1.7	0.1
Locomotion in novel chamber	5.9	7.2	11.2	3.4	-2.5	3.1	-1.4
Locomotion in novel chamber post-restriction	4.0	4.8	7.4	2.7	-2.1	2.6	-0.8
Fecal boli incidents, locomotor time 1	2.4	2.6	4.5	2.1	-1.4	1.8	-1.0
Change in fecal boli incidents, locomotor task	0.4	0.4	0.7	-0.6	0.2	-0.7	0.8
Time >=10cm from walls, locomotor time 1	1.9	1.9	3.2	1.8	-1.6	1.4	0.1
Bouts of movement, locomotor time 1	8.1	8.8	13.3	3.6	-2.1	3.4	-2.4
Total resting periods, locomotor time 1	8.1	8.9	13.9	3.7	-2.3	3.4	-2.2
Rest time, locomotor task time 1	1.4	1.5	2.2	1.3	-0.3	1.5	-1.4
Distance moved, locomotor task time 1	0.7	0.8	1.9	-0.8	-0.1	-0.9	1.4
Vertical activity count, locomotor time 1	1.4	1.5	2.3	-1.5	0.7	-1.3	1.2
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.1	-0.3	0.2	0.5
Bouts of movement, locomotor time 2	3.0	3.3	5.4	2.2	-1.5	2.3	-0.8
Total resting periods, locomotor time 2	2.8	2.9	4.9	2.1	-1.6	2.2	-0.4
Rest time, locomotor task time 2	0.0	0.0	0.1	-0.3	0.3	-0.1	0.0
Distance moved, locomotor task time 2	0.2	0.2	0.5	0.3	-0.7	0.1	0.5
Vertical activity count, locomotor time 2	0.5	0.5	0.8	0.7	-0.2	0.9	-0.9
Light reinforcement 1	3.4	6.2	10.0	2.8	-3.2	2.6	0.5
Light reinforcement 2	2.4	3.2	5.7	1.6	-2.4	1.4	1.6
Bone: marrow area	0.0	0.0	0.0	-0.1	0.1	-0.1	0.1
Bone: maximum diameter	0.1	0.1	0.4	-0.1	-0.1	-0.1	0.6
Bone: maximum force	0.2	0.3	0.4	0.6	-0.5	0.7	-0.3
Bone: maximum moment	0.2	0.3	0.5	0.7	-0.6	0.7	-0.2
Mean time between licks in bursts	1.9	2.6	4.7	1.3	-2.2	1.2	1.7
Mean num. licks in bursts	0.3	0.4	0.7	0.8	-0.5	0.7	-0.4
Cd content in liver	0.1	0.1	0.1	-0.2	0.4	-0.3	-0.1
Co content in liver	1.7	2.0	3.9	-0.7	1.8	-0.7	-2.0
Cu content in liver	1.6	1.9	3.2	-0.9	1.8	-0.8	-1.8
Fe content in liver	1.9	2.3	3.8	-2.0	1.6	-1.6	0.3
K content in liver	1.9	1.9	3.4	1.2	-1.8	1.1	1.3
Mg content in liver	0.6	0.6	1.0	0.5	-0.9	0.4	1.0
Mn content in liver	0.2	0.3	0.5	0.5	-0.7	0.5	0.3
Na content in liver	2.0	2.2	6.5	-1.1	-0.3	-0.9	2.6
Rb content in liver	2.9	3.6	5.2	2.3	-1.2	2.0	-1.8
Se content in liver	0.3	0.4	0.7	0.8	-0.6	0.8	0.1
Sr content in liver	0.0	0.0	0.0	0.1	0.0	-0.0	-0.1
Zn content in liver	0.2	0.2	0.6	-0.0	0.5	-0.0	-0.7
Bone: minimum diameter	0.4	0.8	1.5	0.9	-1.2	0.9	0.4
Time in familiar zone, hab. session 1	0.7	0.6	2.1	0.1	0.6	0.3	-1.4
Time in novel zone, hab. session 1	1.2	1.2	1.7	-1.3	0.7	-1.3	1.0
Total zone transitions, hab. session 1	0.2	0.3	1.0	-0.3	-0.1	-0.3	1.0
Total locomotion distance, hab. session 1	0.7	1.0	1.4	1.2	-1.2	1.1	0.2
Locomotion velocity, hab. session 1	0.8	1.1	1.7	1.1	-1.3	1.1	0.5
Time in familiar zone, hab. session 2	0.3	0.3	0.5	-0.7	0.6	-0.5	0.2
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.0	0.1	-0.1	-0.5
Total zone transitions, hab. session 2	0.4	0.5	0.9	1.0	-0.5	0.8	-0.5
Total locomotion distance, hab. session 2	1.5	2.0	3.0	1.7	-0.8	1.7	-1.3
Locomotion velocity, hab. session 2	1.3	1.8	2.7	1.6	-0.9	1.6	-1.0
Novel to familiar place preference ratio	0.1	0.1	0.4	0.2	-0.0	0.2	-0.6
Novelty place preference	0.2	0.2	0.6	0.1	0.1	0.1	-0.8
Time in novel zone, NPP test	0.2	0.2	0.5	-0.1	0.3	-0.1	-0.7
Total zone transitions, NPP test	0.5	0.8	1.3	1.0	-0.1	0.9	-1.1
Total locomotion distance, NPP test	0.7	1.0	1.6	1.3	-0.8	1.3	-0.4
Locomotion velocity, NPP test	1.0	1.5	2.3	1.5	-1.2	1.5	-0.2
Intraocular pressure	2.2	3.1	4.7	2.2	-1.3	2.0	-1.4
Delta distance traveled before/after self-admin	0.7	0.7	1.0	-1.0	0.3	-1.0	1.0
Delta ambulatory time before/after self-admin	0.7	0.7	1.5	-0.9	0.1	-0.8	1.2
Parametrial fat weight	0.1	0.2	0.4	0.6	-0.5	0.5	0.1
Pavlov. Cond. lever latency	0.5	0.6	1.2	0.8	-1.1	0.7	0.5
Pavlov. Cond. magazine entry latency	0.2	0.2	0.5	-0.4	0.7	-0.3	-0.4
Pavlov. Cond. change in total contacts	0.3	0.3	0.8	0.6	0.2	0.4	-0.9
Pavlov. Cond. index score	0.3	0.4	0.8	-0.5	0.9	-0.4	-0.4
Pavlov. Cond. latency score	0.4	0.5	1.0	-0.6	1.0	-0.5	-0.4
Pavlov. Cond. lever contacts	0.2	0.2	0.5	-0.5	0.7	-0.3	-0.3
Pavlov. Cond. magazine entry number	0.8	1.0	1.9	1.1	-1.4	1.0	0.3
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.8	0.9	-0.0	0.8	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.4	-0.1	0.6	-0.1	-0.6
Pavlov. Cond. response bias	0.2	0.2	0.5	-0.4	0.7	-0.4	-0.4
Pavlov. Cond. lever latency	0.6	0.8	1.5	1.2	-0.8	1.0	-0.5
Pavlov. Cond. magazine entry latency	0.7	0.8	1.4	-1.2	0.8	-1.1	0.4
Pavlov. Cond. change in total contacts	0.6	0.8	1.3	-1.1	0.5	-1.0	0.9
Pavlov. Cond. index score	0.5	0.7	1.2	-1.1	0.5	-0.9	0.7
Pavlov. Cond. latency score	0.4	0.5	0.9	-0.9	0.4	-0.8	0.7
Pavlov. Cond. lever contacts	1.6	2.1	3.5	-1.9	1.0	-1.6	1.2
Pavlov. Cond. magazine entry number	1.3	1.6	2.6	1.6	-0.9	1.4	-0.9
Pavlov. Cond. intertrial magazine entries	3.7	4.8	7.4	2.7	-1.9	2.6	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.8	-0.9	0.3	-0.8	0.7
Pavlov. Cond. response bias	2.2	3.0	4.7	-2.2	1.1	-1.9	1.5
Time in closed arm before self-admin	0.5	0.6	2.1	0.3	0.3	0.2	-1.4
Time in closed arm after self-admin	0.8	0.9	1.3	-1.1	0.5	-1.2	0.8
Time in open arm before self-admin	0.4	0.4	0.6	0.6	-0.7	0.8	0.5
Time in open arm after self-admin	0.2	0.2	0.3	-0.5	0.6	-0.3	0.2
Bone: periosteal estimation	0.0	0.0	0.0	-0.0	-0.1	0.0	0.2
Bone: periosteal perimeter	0.0	0.0	0.1	0.2	-0.1	0.3	-0.3
Bone: post-yield work	0.2	0.3	0.4	-0.5	0.6	-0.6	0.0
Progressive ratio test 1 active lever presses	0.6	0.6	1.1	0.8	-0.3	1.1	-0.8
Progressive ratio test 1 breakpoint	0.6	0.6	1.3	0.8	-0.4	1.1	-0.6
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	-0.2	0.1	-0.1	0.5
Progressive ratio test 2 active lever presses	0.5	0.5	1.0	-0.4	1.0	0.2	-1.0
Progressive ratio test 2 breakpoint	0.4	0.4	1.2	-0.1	0.7	0.3	-1.1
Progressive ratio test 2 inactive lever presses	0.3	0.4	0.8	-0.9	0.8	-0.4	0.1
Incentive Sensitization - Responses	0.8	0.8	1.7	-0.9	1.3	-0.4	-0.6
Incentive Sensitization - Breakpoint	0.6	0.6	1.4	-0.8	1.2	-0.3	-0.6
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.4	0.4	-0.3	0.2
Progressive ratio	2.7	3.1	5.2	1.9	-0.6	1.8	-2.3
Food seeking constrained by brief footshock	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1
Seeking ratio, punishment vs. effort	1.4	1.7	3.8	-1.3	0.2	-1.2	1.9
Retroperitoneal fat weight	0.3	1.0	1.5	1.1	-1.2	1.1	0.3
Reaction time number correct	0.8	1.1	1.8	1.2	-1.4	1.1	-0.0
Reaction time mean minus median	1.1	1.5	2.4	-1.6	1.3	-1.3	0.6
Reaction time mean minus median AUC	1.3	1.7	2.5	-1.6	1.5	-1.3	0.3
Reaction time num false alarms	1.3	1.8	2.9	1.7	-1.2	1.5	-0.7
Reaction time num false alarms AUC	1.9	2.6	4.1	2.0	-1.7	1.8	-0.4
Reaction time trials correct on left	0.8	1.1	1.8	1.2	-1.4	1.1	-0.0
Reaction time trials on left	0.7	1.0	1.6	1.1	-1.3	1.1	-0.1
Reaction time mean	2.6	3.6	5.9	-2.1	2.4	-2.0	-0.4
Reaction time mean AUC	2.1	2.9	5.0	-1.8	2.2	-1.7	-0.7
Median of all reaction times	2.4	3.3	5.9	-1.9	2.4	-1.7	-0.9
Reaction time omissions	0.9	1.2	1.9	-1.4	1.3	-1.2	0.0
Reaction time false alarm rate	0.5	0.7	1.3	1.1	-0.8	1.0	-0.3
Reaction time premature initiation rate	0.1	0.1	0.1	-0.4	0.2	-0.4	0.2
Reaction time premature initiations	0.1	0.1	0.2	0.3	-0.4	0.3	0.2
Std. dev. reaction times	2.2	3.1	4.8	-2.2	1.8	-1.9	0.7
Reaction time trials completed	0.7	1.0	1.6	1.1	-1.3	1.1	-0.1
Reaction time trials AUC	0.7	0.9	1.4	1.1	-1.2	1.0	-0.2
Run reversals in cocaine runway, females	0.9	0.9	2.0	1.1	-0.3	1.4	-0.5
Run reversals in cocaine runway, males	0.6	0.6	1.0	0.9	-0.7	1.0	-0.3
Latency to leave start box in cocaine runway	2.5	2.7	4.2	2.0	-1.7	1.9	-0.3
Latency to leave start box in cocaine runway, F	0.6	0.6	1.0	0.6	-0.9	0.7	1.0
Latency to leave start box in cocaine runway, M	3.6	3.5	5.5	2.3	-1.7	2.0	-1.4
Std. dev. time between licks in bursts	1.0	1.2	2.2	0.9	-1.5	0.9	1.0
Total sessions with >9 infusions	1.7	1.9	3.2	1.6	-1.3	1.8	-0.5
Short access day 1 total inactive lever presses	0.7	0.8	2.8	-0.5	-0.3	-0.1	1.7
Short access day 10 total inactive lever presses	0.7	0.7	1.1	-0.8	1.0	-1.1	-0.4
Short access day 1 total infusions	0.3	0.3	0.4	0.3	-0.7	0.5	0.6
Short access day 10 total infusions	0.4	0.5	1.4	0.1	0.5	0.5	-1.2
Short access total infusions	0.6	0.7	1.3	0.9	-0.5	1.1	-0.6
Short access day 1 locomotion	0.1	0.1	0.4	0.2	-0.6	0.2	0.3
Short access day 10 total locomotion	0.2	0.2	0.5	-0.4	0.0	0.0	0.7
Short access total locomotion	0.4	0.4	0.8	0.7	-0.8	0.9	0.0
One hour access (0.3 mA shock)	1.3	1.6	2.9	-0.8	1.7	-0.5	-1.6
Compulsive drug intake	1.2	1.2	1.8	-1.4	1.1	-1.1	0.7
One hour access (shock baseline)	1.1	1.3	3.6	-0.3	1.1	-0.3	-1.9
Social response proportion	0.8	0.9	1.3	-0.7	1.1	-0.6	-1.1
Social responses	1.3	1.6	2.9	-1.2	1.7	-0.9	-1.2
Social time	3.8	5.0	7.9	-2.8	2.3	-2.6	0.5
Soleus weight	1.0	2.8	4.6	1.7	-2.2	1.4	1.3
Bone: stiffness	0.2	0.3	0.7	0.5	-0.1	0.4	-0.8
Tibialis anterior weight	2.0	6.7	9.8	3.1	-3.1	2.7	0.3
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.6	-0.2	0.5	-0.6
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.9	0.0	0.5	-0.1	-0.9
Time to tail flick, test, before self-admin	0.6	0.6	1.0	1.0	-0.6	0.7	-0.7
Time to tail flick, test, after self-admin	2.0	2.0	3.3	1.8	-1.1	1.5	-1.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	-0.4	0.3	-0.3	-0.1
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.4	-0.3	0.3	-0.1
Tibia length	0.1	0.3	0.4	-0.6	0.5	-0.6	0.4
Ambulatory time before self-admin	0.0	0.0	0.1	0.1	-0.0	0.3	0.1
Ambulatory time after self-admin	0.8	0.9	3.0	-0.6	-0.3	-0.5	1.7
Bone: tissue strength	0.2	0.2	0.5	0.4	-0.0	0.2	-0.7
Total heroin consumption	0.1	0.1	0.4	0.1	0.2	0.1	-0.7
Bone: trabecular number	3.0	4.7	7.3	-2.7	2.0	-2.3	1.4
Bone: trabecular spacing	2.4	3.2	4.8	2.2	-1.3	2.0	-1.4
Bone: trabecular thickness	4.7	5.6	8.9	-3.0	2.5	-2.6	0.7
Bone: trabecular tissue density	0.2	0.3	0.4	-0.6	0.7	-0.4	-0.4
Water consumed over 24 hours	0.4	0.5	1.4	0.6	0.1	0.5	-1.2
Number of responses in last shaping day	0.4	0.4	0.7	-0.7	0.5	-0.8	0.2