Hub : Genes

Gtpbp3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Gtpbp3 0.03 0.02 9.6e-04 0.01 0.02 0.03 0.01 1.3e-02 9.2e-04 5.5e-04 2.3e-02
2 BLA gene expression Gtpbp3 0.23 0.1 3.5e-12 0.21 0.21 0.2 0.04 1.2e-11 2.6e-11 7.9e-11 2.2e-03
3 LHb gene expression Gtpbp3 0.33 0.15 9.6e-07 0.22 0.08 0.22 0.03 7.5e-06 5.4e-03 6.6e-06 6.6e-02
4 OFC gene expression Gtpbp3 0.28 0.14 3.6e-06 0.27 0.09 0.2 0.06 5.0e-07 4.7e-03 1.9e-05 2.0e-02
5 NAcc gene expression Gtpbp3 0.17 0.1 0.0e+00 0.18 0.17 0.17 0.17 2.5e-20 1.8e-19 3.7e-19 1.5e-19
6 IL gene expression Gtpbp3 0.38 0.17 1.4e-07 0.26 0.13 0.23 0.1 5.0e-07 4.8e-04 3.5e-06 2.4e-03
7 PL gene expression Gtpbp3 0.24 0.09 0.0e+00 0.33 0.25 0.33 0.14 1.4e-37 3.2e-27 8.2e-38 4.6e-15
8 RMTg gene expression Gtpbp3 0.36 0.17 5.8e-06 0.18 0.22 0.17 0.18 1.1e-05 1.8e-06 2.3e-05 1.4e-05
9 Brain gene expression Gtpbp3 0.26 0.08 0.0e+00 0.42 0.12 0.41 0.11 5.0e-42 6.1e-11 2.4e-41 3.9e-10
10 pVTA gene expression Gtpbp3 0.09 0.06 1.4e-03 0.07 0.05 0.03 0.03 7.3e-04 2.2e-03 1.5e-02 2.2e-02
11 Brain intron excision ratio chr16_18176545_18177538 0.05 0.03 4.5e-05 0.05 0.03 0.05 0.04 3.4e-05 1.7e-03 1.6e-05 6.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.61.02.41.51.21.10.51.10.71.0-0.81.01.20.3
Area under the delay curve0.60.61.5-0.9-0.6-0.7-1.2-0.7-1.0-0.70.7-0.8-0.7-0.0
BMI with tail0.31.07.52.7-0.10.30.70.90.90.3-0.10.30.0-1.0
BMI without tail0.71.45.92.4-1.1-0.8-0.3-0.7-0.2-1.00.7-0.9-1.2-1.8
Body weight0.41.713.83.70.60.80.70.80.80.50.20.60.6-1.2
Weight adjusted by age0.30.31.4-0.1-0.5-0.3-0.1-0.5-0.4-0.60.7-0.7-0.3-1.2
Bone surface0.91.72.41.11.51.51.11.41.11.4-1.21.51.50.7
Bone volume0.60.93.11.81.11.00.70.90.70.9-0.61.01.10.2
Breakpoint value in progressive ratio session0.60.71.20.10.90.90.81.00.71.0-0.71.11.00.7
Number of licking bursts0.00.00.1-0.3-0.2-0.2-0.0-0.10.1-0.10.1-0.2-0.20.2
Context. condit. distance diff. score0.00.00.1-0.00.0-0.0-0.3-0.1-0.00.00.1-0.00.1-0.2
Locomotion velocity, session 15.15.57.1-0.22.42.52.62.72.62.6-2.32.62.51.5
Locomotion distance, session 14.86.17.9-0.72.52.62.82.72.72.6-2.62.62.52.3
Locomotion velocity, session 20.20.31.61.20.30.40.50.50.50.3-0.00.30.4-0.4
Locomotion distance, session 23.75.17.2-0.62.12.32.72.62.52.4-2.52.32.22.1
Locomotion velocity, session 30.20.30.4-0.50.50.50.40.70.60.6-0.60.60.50.1
Locomotion distance, session 31.31.42.0-0.21.21.21.31.41.41.3-1.31.31.20.9
Stereotopy head waving bouts, day 30.30.40.6-0.20.80.70.30.70.50.7-0.60.70.70.6
Stereotopy head waving duration, day 30.10.10.20.00.40.3-0.10.30.10.3-0.10.30.40.4
Locomotion velocity, session 70.40.52.5-1.60.30.30.80.20.60.3-0.60.20.31.0
Locomotion distance, session 70.30.44.1-2.0-0.0-0.00.2-0.10.10.0-0.4-0.1-0.00.6
Stereotopy head waving bouts, day 71.82.12.71.51.61.51.31.61.61.5-1.11.51.50.9
Stereotopy head waving duration, day 70.60.83.61.90.80.80.50.90.70.8-0.30.70.80.2
Locomotion velocity, session 82.63.14.1-0.81.81.82.01.91.81.9-1.91.81.81.4
Locomotion distance, session 82.33.34.60.11.81.92.12.02.11.9-1.91.91.91.4
Degree of sensitization distance0.80.81.5-1.2-0.8-0.9-0.8-1.1-0.9-0.90.6-1.0-0.9-0.1
Degree of sensitization stereotypy1.31.43.31.81.11.11.11.31.41.1-0.81.11.10.6
Conditioned locomotion0.10.10.8-0.9-0.4-0.4-0.2-0.2-0.2-0.20.3-0.3-0.3-0.4
Cocaine response after cond. corrected3.94.36.4-1.1-2.2-2.3-2.5-2.3-2.4-2.22.0-2.2-2.1-1.2
Cocaine response after cond. not corrected2.12.33.4-1.7-1.5-1.6-1.8-1.6-1.8-1.51.2-1.4-1.5-0.8
Cocaine response before conditioning2.53.04.2-1.11.81.81.91.71.61.8-2.02.01.81.2
Saline control response1.01.31.80.61.21.21.21.31.31.2-1.21.41.20.6
Bone: connectivity density0.71.11.70.51.31.20.81.20.91.2-0.91.21.30.8
Bone: cortical apparent density0.00.00.1-0.40.0-0.0-0.00.1-0.00.0-0.10.1-0.0-0.3
Bone: cortical area1.62.420.64.5-0.6-0.4-0.1-0.4-0.3-0.71.0-0.3-0.6-1.6
Bone: cortical porosity1.31.42.90.41.21.31.71.21.31.2-1.11.11.21.0
Bone: cortical porosity2.02.23.70.21.61.61.91.51.51.5-1.51.41.51.3
Bone: cortical thickness1.22.019.64.4-0.00.20.50.30.4-0.10.40.3-0.0-1.4
Bone: cortical thickness0.81.09.73.10.00.20.40.30.40.00.20.30.1-0.6
Bone: cortical tissue density0.00.00.3-0.60.0-0.0-0.00.1-0.00.0-0.10.1-0.1-0.3
Condit. Reinf. active minus inactive responses1.11.23.41.81.11.11.01.11.01.0-0.71.11.00.7
Condit. Reinf. active-inactive response ratio0.10.11.21.10.20.1-0.10.1-0.00.10.10.10.20.1
Condit. Reinf. active responses1.41.75.12.21.31.31.21.21.11.1-0.81.21.30.9
Condit. Reinf. inactive responses0.20.31.31.20.40.50.60.40.50.3-0.30.40.40.3
Incentive salience index mean3.23.96.22.52.12.12.02.12.02.0-1.52.02.11.2
Condit. Reinf. lever presses5.97.99.33.03.03.02.93.13.02.9-2.32.93.01.6
Condit. Reinf. active minus inactive responses0.40.50.8-0.20.70.80.70.80.70.8-0.90.90.80.4
Condit. Reinf. active-inactive response ratio0.10.10.30.6-0.1-0.00.10.00.0-0.10.1-0.0-0.1-0.6
Condit. Reinf. active responses0.60.81.6-1.30.80.90.80.80.70.9-1.11.00.90.7
Condit. Reinf. inactive responses0.60.75.6-2.40.30.30.20.20.10.4-0.70.40.40.9
Condit. Reinf. lever presses0.10.10.2-0.4-0.3-0.3-0.3-0.4-0.4-0.30.2-0.2-0.2-0.5
Condit. Reinf. lever reinforcers received0.10.10.8-0.90.10.20.20.10.10.2-0.40.30.20.0
Conditioned reinforcement - actives0.70.72.21.4-1.1-0.9-0.2-0.3-0.0-0.50.7-0.5-0.5-1.5
Conditioned reinforcement - inactives5.05.69.32.7-2.2-2.0-1.8-2.2-1.7-2.42.8-2.4-2.4-3.0
Conditioned locomotion2.22.73.71.9-1.9-1.7-1.4-1.4-1.2-1.61.7-1.7-1.6-1.9
Patch foraging indifference point 0 sec0.10.20.80.90.1-0.1-0.6-0.3-0.5-0.30.9-0.2-0.0-0.4
Patch foraging indifference point AUC0.50.61.8-1.0-0.4-0.6-1.3-0.6-1.2-0.50.6-0.4-0.4-0.6
Delay disc. indifference point, 0s delay0.20.21.3-1.1-0.0-0.1-0.2-0.2-0.10.1-0.4-0.20.01.0
Delay disc. indifference point, 16s delay1.81.93.9-2.0-1.2-1.3-1.7-1.3-1.5-1.20.9-1.3-1.4-0.3
Delay disc. indifference point, 2s delay0.80.92.1-0.90.90.90.40.90.51.0-0.81.01.01.4
Delay disc. indifference point, 24s delay1.11.11.8-0.5-0.9-0.9-1.0-1.2-1.0-1.21.0-1.2-1.4-0.9
Delay disc. indifference point, 4s delay0.20.20.60.70.40.50.30.60.50.6-0.40.50.40.4
Delay disc. indifference point, 8s delay1.71.83.8-0.6-1.1-1.3-1.9-1.5-1.8-1.31.4-1.4-1.2-0.6
Indifference point function ln k0.30.51.61.3-0.8-0.50.4-0.40.4-0.50.5-0.8-0.7-0.7
Indifference point function log k0.30.51.61.3-0.8-0.50.4-0.40.4-0.50.5-0.8-0.7-0.7
Patch foraging total patch changes 0 sec0.50.82.21.5-0.4-0.5-0.8-0.7-0.7-0.81.3-0.7-0.5-1.0
Patch foraging total patch changes 12 sec0.40.51.30.4-0.4-0.5-1.1-0.7-1.2-0.60.7-0.3-0.5-0.6
Patch foraging total patch changes 18 sec0.30.32.0-1.40.60.3-0.60.1-0.60.3-0.10.20.40.6
Patch foraging total patch changes 24 sec0.10.20.5-0.50.70.5-0.30.4-0.10.3-0.10.50.30.2
Patch foraging total patch changes 6 sec0.10.10.40.60.0-0.1-0.6-0.1-0.5-0.20.60.0-0.0-0.3
Patch foraging time to switch 0 sec0.40.71.6-0.60.60.70.60.70.60.8-1.00.90.91.3
Patch foraging water rate 0 sec0.30.53.01.7-0.2-0.10.50.10.3-0.10.4-0.2-0.2-1.3
Patch foraging water rate 12 sec0.20.31.00.9-0.3-0.11.0-0.10.7-0.30.1-0.5-0.4-0.7
Patch foraging water rate 18 sec1.01.43.70.01.01.11.91.11.71.2-1.21.01.10.6
Patch foraging water rate 24 sec1.41.96.71.51.01.42.61.12.00.9-1.20.90.9-0.0
Patch foraging water rate 6 sec0.50.82.30.9-0.9-0.70.4-0.70.1-0.90.8-1.1-1.0-1.5
Seeking ratio, delayed vs. immediate footshock0.30.40.91.0-0.7-0.40.70.20.7-0.3-0.2-0.7-0.9-0.5
Distance traveled before self-admin0.10.20.6-0.10.20.40.40.40.30.5-0.00.40.8-0.4
Distance traveled after self-admin0.30.30.90.70.60.71.00.20.70.2-0.20.20.4-0.4
Extensor digitorum longus weight0.10.32.61.60.20.20.20.40.40.2-0.10.30.2-0.5
Bone: elastic displacement1.51.72.9-0.41.41.41.71.41.61.3-1.41.41.30.6
Bone: elastic work0.40.54.12.0-0.10.00.30.10.3-0.10.3-0.0-0.1-0.9
Bone: endosteal estimation0.81.72.5-0.3-1.4-1.4-1.4-1.6-1.5-1.41.4-1.4-1.4-0.5
Bone: endosteal perimeter0.81.62.11.3-1.3-1.2-1.0-1.4-1.3-1.41.4-1.3-1.3-0.8
Epididymis fat weight0.61.47.52.7-0.6-0.5-0.3-0.7-0.6-0.91.3-0.9-0.8-1.7
Delta time in closed arm before/after self-admin1.91.84.1-1.1-0.4-0.8-2.0-1.9-1.9-1.41.3-1.3-1.10.5
Delta time in open arm before/after self-admin1.41.32.0-0.51.11.11.11.41.11.3-1.41.31.10.9
Diff in mean of infusions in LGA sessions0.20.20.50.60.10.1-0.1-0.7-0.4-0.20.6-0.10.3-0.7
Delay discount exponential model param0.50.51.30.60.50.61.10.71.00.6-0.70.70.70.2
Extinction: sum of active levers before priming2.12.13.6-0.01.91.81.41.31.31.4-1.41.41.71.4
Active lever presses in extinction session 60.10.10.20.20.10.10.20.30.30.2-0.40.30.00.4
Bone: final force2.33.818.34.3-1.5-1.3-1.2-1.3-1.2-1.62.0-1.4-1.4-2.1
Bone: final moment2.74.316.84.1-1.8-1.6-1.4-1.6-1.5-1.92.2-1.6-1.7-2.2
Food consumed during 24 hour testing period2.53.04.00.71.71.71.91.81.91.8-1.72.01.71.7
Glucose0.20.42.21.5-0.3-0.3-0.3-0.4-0.5-0.50.6-0.3-0.4-0.4
Heart weight0.30.53.92.0-0.2-0.10.2-0.40.0-0.40.3-0.1-0.3-1.0
Delay discount hyperbolic model param0.20.20.70.40.20.30.80.30.60.3-0.40.30.3-0.1
Intermittent access intake day 1-15 change0.50.51.50.50.70.81.10.51.20.5-0.70.40.70.1
Intermittent access intake escalation0.40.41.00.90.60.71.00.41.00.3-0.50.30.6-0.1
Intermittent access intake escalation 20.10.10.40.60.60.50.2-0.20.4-0.0-0.1-0.20.30.0
Intermitt. access day 1 inactive lever presses0.20.20.80.5-0.4-0.30.0-0.3-0.0-0.40.4-0.3-0.6-0.9
Intermitt. access day 15 inactive lever presses0.70.82.2-0.30.30.61.51.01.50.7-1.10.70.50.0
Intermitt. access escalation Index0.20.21.4-1.2-0.00.10.20.10.0-0.0-0.3-0.3-0.20.3
Intermittent access day 1 total infusions2.83.27.50.7-2.7-2.5-1.7-1.2-1.8-1.41.8-1.3-1.7-2.0
Intermittent access day 15 total infusions0.91.02.51.0-1.6-1.4-0.4-0.6-0.5-0.80.8-0.7-0.9-1.5
Intermittent access terminal intake (last 3 days)0.70.71.80.4-1.3-1.2-0.8-0.6-0.8-0.60.8-0.7-0.6-1.0
Intermittent access total infusions2.22.55.20.9-2.3-2.1-1.5-1.1-1.5-1.31.6-1.1-1.4-2.0
Intermittent access day 1 locomotion2.42.54.41.3-2.1-1.9-1.5-1.1-1.5-1.31.8-1.1-1.4-2.1
Intermittent access day 15 total locomotion0.20.20.50.7-0.4-0.4-0.5-0.1-0.4-0.10.5-0.10.0-0.4
Intermittent access total locomotion1.92.13.41.3-1.7-1.7-1.6-1.2-1.6-1.21.8-1.0-1.0-1.8
Intermittent access standard deviation0.80.91.41.0-0.8-0.7-0.6-1.2-0.4-1.10.8-1.2-1.0-1.1
Left kidney weight0.20.71.40.31.21.00.50.90.60.9-0.51.11.00.0
Right kidney weight0.20.61.50.61.00.90.50.80.60.9-0.51.20.90.0
Cocaine induced anxiety0.30.40.9-0.4-0.5-0.5-1.0-0.6-0.8-0.60.7-0.4-0.4-0.5
Post-drug Anxiety0.10.20.8-0.90.10.1-0.20.3-0.20.3-0.30.60.30.4
Baseline Anxiety0.60.61.7-0.80.50.50.40.80.40.9-1.00.80.61.3
Tail length0.10.41.41.2-0.2-0.2-0.3-1.0-0.3-0.70.5-0.5-0.3-1.0
Length with tail0.20.63.01.71.00.90.30.30.40.40.10.60.9-0.4
Length without tail0.71.62.91.51.71.50.81.40.91.3-0.41.31.60.6
Times rat made contact with spout0.30.30.6-0.30.50.50.60.50.80.5-0.60.70.50.4
Lifetime Intake2.22.55.41.1-2.3-2.1-1.3-1.0-1.3-1.31.6-1.1-1.5-2.1
Liver weight, left1.52.33.0-1.11.41.41.61.71.61.7-1.71.51.51.5
Liver weight, right0.81.31.8-0.31.31.31.01.31.21.3-1.11.21.20.8
Locomotor activity3.96.110.01.82.62.62.72.73.22.6-2.22.32.61.8
Locomotor testing distance1.52.44.50.81.61.61.61.82.11.7-1.51.41.61.1
Locomotor testing rearing3.45.37.5-0.42.72.61.82.32.22.6-2.22.42.72.4
Locomotion in novel chamber0.40.41.6-1.30.40.40.50.61.00.6-0.50.80.40.2
Locomotion in novel chamber post-restriction2.93.56.3-0.32.52.31.62.01.72.0-1.51.92.11.8
Fecal boli incidents, locomotor time 10.60.61.21.0-0.7-0.7-0.7-0.9-0.8-0.80.7-1.1-0.7-0.2
Change in fecal boli incidents, locomotor task0.20.21.1-1.0-0.4-0.4-0.2-0.5-0.4-0.50.2-0.1-0.5-0.2
Time >=10cm from walls, locomotor time 10.30.40.90.3-0.3-0.5-0.5-0.9-0.8-0.70.6-0.7-0.50.1
Bouts of movement, locomotor time 10.50.51.10.00.50.50.50.80.50.9-0.70.71.10.9
Total resting periods, locomotor time 10.60.71.4-0.20.50.50.70.90.61.0-0.90.81.01.2
Rest time, locomotor task time 10.60.61.40.0-1.0-0.9-0.4-0.7-0.5-0.90.5-1.2-1.2-0.7
Distance moved, locomotor task time 10.10.10.3-0.50.20.0-0.4-0.3-0.40.00.20.20.20.2
Vertical activity count, locomotor time 10.50.50.90.30.90.80.80.60.70.7-0.60.81.00.2
Time >=10cm from walls, locomotor time 20.70.81.41.2-1.2-1.0-0.1-1.0-0.3-1.00.4-1.1-1.1-0.6
Bouts of movement, locomotor time 21.21.32.1-0.31.11.00.81.31.01.3-0.91.51.41.3
Total resting periods, locomotor time 20.91.01.7-0.61.00.90.51.10.81.1-0.71.31.21.3
Rest time, locomotor task time 20.00.10.20.40.00.0-0.4-0.2-0.2-0.20.3-0.1-0.1-0.1
Distance moved, locomotor task time 20.60.61.2-0.1-0.9-0.9-0.7-0.9-0.8-0.90.7-1.1-0.8-0.6
Vertical activity count, locomotor time 20.10.20.40.6-0.2-0.20.1-0.4-0.1-0.40.2-0.6-0.2-0.6
Light reinforcement 10.30.51.0-0.8-0.6-0.6-0.9-1.0-0.9-0.70.7-0.6-0.5-0.1
Light reinforcement 23.24.26.8-1.5-1.8-2.0-2.6-2.4-2.3-2.12.2-2.2-1.9-1.1
Bone: marrow area0.71.52.1-0.4-1.2-1.3-1.3-1.5-1.4-1.31.2-1.3-1.3-0.4
Bone: maximum diameter0.91.67.02.6-1.0-0.8-0.7-1.0-1.0-1.11.3-0.9-1.0-1.5
Bone: maximum force1.83.126.85.2-0.8-0.5-0.3-0.5-0.4-0.91.3-0.6-0.7-1.5
Bone: maximum moment1.83.022.94.8-1.0-0.8-0.5-0.8-0.7-1.11.5-0.8-1.0-1.5
Mean time between licks in bursts0.81.27.02.6-0.8-0.6-0.3-0.6-0.4-0.91.0-0.8-0.8-1.0
Mean num. licks in bursts0.20.20.40.20.50.50.30.50.40.4-0.50.60.50.0
Cd content in liver4.75.26.10.4-2.4-2.4-2.3-2.3-2.4-2.42.3-2.3-2.4-2.5
Co content in liver0.00.00.2-0.5-0.1-0.1-0.1-0.1-0.1-0.10.10.0-0.10.0
Cu content in liver4.04.95.9-0.72.32.42.42.32.42.3-2.22.32.31.9
Fe content in liver0.20.20.3-0.50.50.50.30.50.10.5-0.50.50.50.2
K content in liver0.50.53.9-2.00.30.20.20.20.10.4-0.70.00.31.1
Mg content in liver0.40.41.3-1.1-0.6-0.6-0.7-0.6-0.8-0.50.4-0.7-0.60.0
Mn content in liver0.20.20.6-0.10.40.50.80.50.50.5-0.40.50.40.3
Na content in liver2.52.63.4-1.51.51.51.61.71.71.7-1.91.51.51.6
Rb content in liver3.54.35.11.8-2.1-2.1-2.2-2.1-2.3-2.12.2-2.0-2.1-1.7
Se content in liver0.30.30.50.60.70.70.60.60.30.6-0.40.60.70.4
Sr content in liver0.60.62.5-1.60.60.50.60.60.50.6-0.80.60.60.8
Zn content in liver0.00.00.30.30.10.0-0.1-0.1-0.20.00.10.00.10.5
Bone: minimum diameter0.61.15.42.3-0.8-0.7-0.5-0.8-0.7-0.91.0-0.6-0.8-1.1
Time in familiar zone, hab. session 10.00.00.2-0.00.10.00.00.1-0.00.10.00.10.0-0.5
Time in novel zone, hab. session 10.00.00.10.2-0.1-0.1-0.0-0.2-0.1-0.20.1-0.1-0.10.3
Total zone transitions, hab. session 11.11.52.1-0.61.31.31.41.41.21.3-1.41.31.20.9
Total locomotion distance, hab. session 13.24.55.9-0.52.22.22.42.32.12.3-2.32.22.12.2
Locomotion velocity, hab. session 12.84.05.2-0.62.02.12.32.12.02.1-2.22.12.02.0
Time in familiar zone, hab. session 20.20.20.6-0.6-0.2-0.3-0.4-0.3-0.4-0.30.2-0.3-0.3-0.8
Time in novel zone, hab. session 20.10.10.20.5-0.4-0.4-0.3-0.4-0.3-0.30.4-0.4-0.30.3
Total zone transitions, hab. session 20.20.30.6-0.30.50.50.80.60.60.6-0.60.60.50.4
Total locomotion distance, hab. session 22.12.73.90.71.61.72.01.81.71.7-1.71.81.61.6
Locomotion velocity, hab. session 22.43.24.60.61.81.92.21.91.91.9-1.81.91.81.7
Novel to familiar place preference ratio1.11.21.6-0.3-1.2-1.3-1.1-1.2-1.2-1.11.2-1.2-1.2-0.2
Novelty place preference1.21.21.6-0.4-1.2-1.3-1.1-1.2-1.2-1.21.2-1.3-1.2-0.1
Time in novel zone, NPP test0.80.91.2-0.6-1.1-1.1-0.9-1.1-1.0-1.00.9-1.1-1.00.1
Total zone transitions, NPP test1.92.73.7-0.21.61.71.91.81.61.7-1.71.71.71.5
Total locomotion distance, NPP test4.05.57.8-0.42.42.42.82.52.52.5-2.52.52.42.0
Locomotion velocity, NPP test3.24.66.7-0.32.12.22.62.32.32.2-2.32.32.11.9
Intraocular pressure1.31.82.41.5-1.3-1.3-1.2-1.4-1.1-1.51.5-1.3-1.4-1.3
Delta distance traveled before/after self-admin0.10.10.50.70.40.40.5-0.30.3-0.20.0-0.1-0.1-0.2
Delta ambulatory time before/after self-admin0.10.10.30.60.40.40.4-0.10.3-0.1-0.1-0.0-0.10.0
Parametrial fat weight1.83.55.11.3-1.8-1.8-1.5-1.8-1.4-2.12.0-2.2-2.3-2.2
Pavlov. Cond. lever latency4.25.36.6-1.9-2.6-2.5-2.1-2.6-2.4-2.42.2-2.5-2.5-1.3
Pavlov. Cond. magazine entry latency0.20.21.31.1-0.3-0.3-0.4-0.3-0.1-0.40.3-0.3-0.4-0.5
Pavlov. Cond. change in total contacts1.01.05.42.30.90.90.70.90.90.8-0.50.80.9-0.3
Pavlov. Cond. index score1.72.22.81.41.61.61.41.61.71.5-1.41.61.60.8
Pavlov. Cond. latency score2.83.64.31.62.12.01.72.12.02.0-1.82.12.01.1
Pavlov. Cond. lever contacts3.13.75.22.32.12.01.62.12.02.0-1.62.12.10.9
Pavlov. Cond. magazine entry number0.20.21.6-1.3-0.2-0.2-0.1-0.3-0.4-0.10.1-0.2-0.20.3
Pavlov. Cond. intertrial magazine entries1.41.72.20.81.51.51.31.21.21.3-1.21.41.51.3
Pavlov. Cond. lever-magazine prob. diff.1.21.52.01.21.31.31.11.31.41.2-1.11.31.30.5
Pavlov. Cond. response bias0.40.42.21.50.60.60.40.60.70.5-0.40.60.6-0.1
Pavlov. Cond. lever latency0.20.31.1-1.10.20.30.50.50.40.4-0.60.20.20.6
Pavlov. Cond. magazine entry latency0.40.51.81.3-0.3-0.4-1.1-0.4-0.8-0.50.6-0.2-0.4-0.7
Pavlov. Cond. change in total contacts0.20.21.31.1-0.2-0.2-0.5-0.4-0.2-0.40.5-0.2-0.1-0.7
Pavlov. Cond. index score0.50.62.71.7-0.4-0.5-0.9-0.7-0.7-0.60.8-0.3-0.4-0.9
Pavlov. Cond. latency score0.30.41.51.2-0.2-0.3-0.8-0.4-0.6-0.40.5-0.1-0.2-0.7
Pavlov. Cond. lever contacts0.20.31.61.3-0.2-0.2-0.6-0.5-0.4-0.40.5-0.2-0.1-0.7
Pavlov. Cond. magazine entry number1.01.23.9-2.00.70.81.10.81.00.9-1.00.60.81.4
Pavlov. Cond. intertrial magazine entries0.70.94.6-2.10.60.61.10.50.70.7-0.90.40.60.7
Pavlov. Cond. lever-magazine prob. diff.0.60.73.01.7-0.5-0.5-1.0-0.7-0.7-0.70.9-0.4-0.4-1.0
Pavlov. Cond. response bias0.40.62.81.7-0.4-0.4-0.8-0.6-0.6-0.60.7-0.4-0.4-1.0
Time in closed arm before self-admin1.82.07.02.4-1.3-1.0-0.2-0.6-0.3-1.11.5-1.4-1.1-2.6
Time in closed arm after self-admin6.16.210.20.9-2.2-2.3-2.4-2.8-2.4-2.82.8-3.2-2.8-2.1
Time in open arm before self-admin3.53.85.3-0.92.32.21.61.81.72.0-1.92.32.32.1
Time in open arm after self-admin10.711.715.5-0.33.53.63.73.73.83.7-3.73.93.72.5
Bone: periosteal estimation0.81.66.12.5-1.1-1.0-0.8-1.1-1.0-1.21.3-0.9-1.1-1.1
Bone: periosteal perimeter1.62.712.73.6-1.3-1.1-1.0-1.2-1.2-1.41.7-1.0-1.3-1.5
Bone: post-yield work0.10.10.50.50.20.30.50.30.20.2-0.30.40.20.7
Progressive ratio test 1 active lever presses0.60.61.51.1-1.0-0.9-0.6-0.2-0.6-0.40.9-0.2-0.4-1.2
Progressive ratio test 1 breakpoint0.30.41.21.1-0.8-0.6-0.20.0-0.2-0.20.6-0.0-0.2-1.0
Progressive ratio test 1 inactive lever presses0.80.82.41.4-1.2-0.80.0-0.40.0-0.70.8-0.6-1.1-1.6
Progressive ratio test 2 active lever presses0.80.91.50.5-1.2-1.2-1.2-0.7-1.1-0.61.2-0.5-0.5-1.1
Progressive ratio test 2 breakpoint0.50.61.20.5-1.1-1.0-1.0-0.5-0.9-0.40.9-0.4-0.3-0.9
Progressive ratio test 2 inactive lever presses0.60.72.11.2-1.2-1.0-0.2-0.2-0.2-0.50.7-0.3-0.6-1.4
Incentive Sensitization - Responses1.41.42.5-0.8-1.6-1.5-1.5-1.0-1.4-0.91.1-1.2-1.0-0.6
Incentive Sensitization - Breakpoint1.11.22.1-0.9-1.4-1.4-1.4-0.9-1.3-0.80.9-1.0-0.8-0.4
Sum of active levers in priming session hrs 5-61.11.01.7-0.51.01.11.20.71.10.8-1.31.10.81.2
Progressive ratio0.30.30.70.2-0.5-0.6-0.4-0.8-0.8-0.60.4-0.4-0.4-0.4
Food seeking constrained by brief footshock0.20.32.1-1.40.20.1-0.20.1-0.20.1-0.30.40.20.5
Seeking ratio, punishment vs. effort0.70.81.4-0.90.80.90.81.21.11.0-0.91.00.80.7
Retroperitoneal fat weight0.51.89.13.0-0.9-0.7-0.3-0.8-0.6-1.11.5-1.2-1.0-1.6
Reaction time number correct3.75.38.40.62.42.42.92.72.72.4-2.32.42.21.4
Reaction time mean minus median0.40.50.8-0.80.90.70.10.90.30.8-0.50.80.70.9
Reaction time mean minus median AUC0.30.40.9-0.40.90.70.20.60.20.6-0.40.60.60.9
Reaction time num false alarms0.10.20.40.30.60.2-0.6-0.1-0.50.00.50.20.20.7
Reaction time num false alarms AUC0.10.20.50.10.50.2-0.5-0.1-0.6-0.00.50.10.00.7
Reaction time trials correct on left3.75.38.40.62.42.42.92.72.72.4-2.32.42.21.4
Reaction time trials on left3.85.48.40.72.52.52.92.72.72.4-2.32.42.21.4
Reaction time mean1.92.64.2-0.4-1.3-1.5-2.1-1.8-2.1-1.71.8-1.7-1.7-1.0
Reaction time mean AUC1.52.03.4-0.9-1.2-1.4-1.8-1.6-1.8-1.51.5-1.4-1.5-0.6
Median of all reaction times3.24.46.0-0.3-2.0-2.1-2.4-2.4-2.4-2.32.2-2.2-2.3-1.5
Reaction time omissions0.30.41.3-0.21.10.7-0.20.3-0.20.50.10.70.70.8
Reaction time false alarm rate0.81.12.80.0-0.6-0.8-1.7-1.2-1.6-1.01.4-0.9-0.8-0.1
Reaction time premature initiation rate3.14.16.8-0.92.62.41.82.11.62.2-2.12.22.31.6
Reaction time premature initiations5.78.112.0-0.43.53.22.93.12.73.0-2.93.13.02.1
Std. dev. reaction times0.10.20.4-0.20.70.4-0.40.3-0.30.40.20.50.40.4
Reaction time trials completed3.85.48.40.72.52.52.92.72.72.4-2.32.42.21.4
Reaction time trials AUC3.14.57.30.72.22.22.72.52.52.2-2.12.11.91.2
Run reversals in cocaine runway, females0.70.71.61.3-0.6-0.5-0.4-1.1-0.7-0.70.9-0.6-0.3-1.3
Run reversals in cocaine runway, males2.12.03.6-1.81.61.50.71.40.91.4-1.31.41.11.9
Latency to leave start box in cocaine runway0.50.53.71.9-0.6-0.5-0.3-0.1-0.4-0.30.3-0.5-0.70.0
Latency to leave start box in cocaine runway, F0.40.54.22.0-0.6-0.4-0.10.1-0.1-0.10.2-0.3-0.5-0.3
Latency to leave start box in cocaine runway, M1.71.72.9-0.3-1.4-1.5-1.4-1.5-1.4-1.41.1-1.3-1.7-0.4
Std. dev. time between licks in bursts0.50.61.81.4-0.6-0.5-0.4-0.7-0.6-0.70.8-0.5-0.5-1.0
Total sessions with >9 infusions1.31.43.00.9-1.3-1.2-1.3-0.7-1.3-1.01.7-0.6-0.9-1.7
Short access day 1 total inactive lever presses4.55.08.51.7-2.8-2.4-1.4-2.1-1.6-2.32.1-2.3-2.5-2.9
Short access day 10 total inactive lever presses0.30.40.8-0.70.90.80.50.30.50.3-0.70.30.10.9
Short access day 1 total infusions1.31.44.31.8-1.6-1.2-0.5-0.5-0.6-0.81.2-0.6-0.8-2.1
Short access day 10 total infusions0.80.92.71.0-1.7-1.2-0.0-0.1-0.0-0.50.6-0.5-0.9-1.6
Short access total infusions1.41.64.01.4-1.9-1.6-0.7-0.5-0.8-0.91.3-0.6-1.1-2.0
Short access day 1 locomotion3.33.65.91.9-2.0-1.8-1.2-1.8-1.3-2.02.1-1.8-2.0-2.4
Short access day 10 total locomotion0.50.63.61.9-0.4-0.20.4-0.10.3-0.30.5-0.1-0.1-1.4
Short access total locomotion1.51.64.32.0-1.4-1.2-0.6-0.7-0.7-1.01.4-0.7-1.0-2.1
One hour access (0.3 mA shock)1.51.73.30.9-1.8-1.7-1.1-1.3-1.1-1.31.3-1.2-1.2-1.4
Compulsive drug intake0.40.41.5-1.2-0.0-0.3-0.7-0.7-0.7-0.60.3-0.4-0.50.4
One hour access (shock baseline)2.12.44.52.0-2.0-1.7-1.2-1.2-1.1-1.31.6-1.3-1.2-2.1
Social response proportion0.10.20.70.80.60.4-0.30.0-0.0-0.00.40.30.2-0.3
Social responses1.41.72.51.21.61.61.21.41.41.4-1.01.41.50.7
Social time0.20.20.50.10.60.60.70.30.50.3-0.10.20.50.7
Soleus weight1.33.74.70.4-2.0-2.0-2.0-2.0-2.1-2.12.2-2.0-2.0-1.9
Bone: stiffness1.52.418.34.3-0.9-0.6-0.4-0.5-0.4-0.91.2-0.8-0.8-1.5
Tibialis anterior weight0.82.73.51.31.71.71.51.81.91.7-1.51.91.71.3
Time to tail flick, vehicle, before self-admin0.90.91.9-1.0-1.1-1.2-1.2-0.8-1.4-0.50.9-0.4-0.4-0.7
Time to tail flick, vehicle, after self-admin0.60.72.41.2-1.3-1.0-0.0-0.2-0.1-0.50.5-0.4-0.6-1.5
Time to tail flick, test, before self-admin0.20.20.60.8-0.3-0.20.0-0.2-0.0-0.20.5-0.1-0.3-0.7
Time to tail flick, test, after self-admin0.50.50.9-0.7-1.0-1.0-0.7-0.9-0.8-0.70.4-0.4-0.6-0.3
Delta time to tail flick, vehicle, before/after SA0.30.31.71.3-0.20.20.80.40.90.1-0.40.1-0.0-0.6
Delta time to tail flick, test, before/after SA0.20.20.7-0.8-0.6-0.5-0.3-0.5-0.3-0.4-0.2-0.2-0.20.1
Tibia length0.10.32.71.7-0.1-0.0-0.3-0.0-0.2-0.20.2-0.2-0.1-0.7
Ambulatory time before self-admin0.20.20.50.50.10.30.50.40.40.30.10.20.6-0.7
Ambulatory time after self-admin0.60.61.41.10.80.91.20.71.00.5-0.20.30.6-0.7
Bone: tissue strength0.00.00.10.2-0.00.10.20.10.20.00.00.00.00.2
Total heroin consumption0.20.30.9-0.40.50.2-0.7-0.5-0.9-0.10.4-0.10.10.8
Bone: trabecular number0.61.01.51.21.21.20.61.10.61.1-0.81.11.20.3
Bone: trabecular spacing0.40.50.8-0.2-0.9-0.8-0.5-0.8-0.6-0.80.7-0.7-0.9-0.2
Bone: trabecular thickness0.91.01.40.71.21.21.11.11.11.1-0.91.11.10.2
Bone: trabecular tissue density0.40.51.50.20.50.61.20.71.00.6-0.80.70.50.7
Water consumed over 24 hours1.41.72.40.21.51.41.41.31.31.4-1.21.61.50.9
Number of responses in last shaping day0.50.51.40.7-1.2-0.9-0.1-0.3-0.3-0.60.6-0.5-0.8-1.2