Hub : Genes

Gtpbp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Gtpbp1	0.04	0.02	6.1e-04	0.04	0.03	0.05	0.05	1.1e-05	1.2e-04	5.7e-06	7.9e-06
2	Brain	mRNA stability	Gtpbp1	0.17	0.06	7.2e-16	0.14	0.15	0.17	0.16	4.4e-13	6.6e-14	1.9e-15	7.1e-15
3	Adipose	gene expression	Gtpbp1	0.13	0.06	5.6e-17	0.15	0.13	0.12	0.14	1.4e-16	3.8e-14	9.9e-14	2.2e-15
4	PL	mRNA stability	Gtpbp1	0.03	0.02	2.1e-03	0.03	0.03	0.01	0.03	4.2e-04	8.1e-04	8.2e-03	3.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.1	0.1	-0.3	-0.4	0.2	-0.3
Area under the delay curve	3.8	4.5	6.3	-2.5	-2.3	2.3	-0.9
BMI with tail	0.7	2.5	3.5	1.6	1.6	-1.9	1.2
BMI without tail	0.6	1.9	2.7	1.6	1.6	-1.3	0.7
Body weight	1.9	8.4	12.3	3.5	3.3	-3.2	0.8
Weight adjusted by age	0.6	0.9	1.6	1.1	1.3	-0.7	0.6
Bone surface	0.1	0.2	0.2	-0.4	-0.4	0.5	-0.4
Bone volume	0.0	0.0	0.1	-0.2	-0.3	0.1	-0.1
Breakpoint value in progressive ratio session	0.1	0.2	0.3	-0.4	-0.5	-0.1	-0.4
Number of licking bursts	0.4	0.7	1.3	-0.9	-0.8	1.1	0.1
Context. condit. distance diff. score	8.7	10.5	14.1	3.8	3.4	-3.4	2.2
Locomotion velocity, session 1	0.5	0.6	1.2	-0.1	-0.1	1.1	-1.1
Locomotion distance, session 1	3.7	4.6	8.1	-2.2	-2.1	2.8	-1.0
Locomotion velocity, session 2	0.1	0.1	0.1	-0.1	-0.3	0.1	-0.4
Locomotion distance, session 2	6.7	9.4	11.6	-3.2	-3.2	3.4	-2.3
Locomotion velocity, session 3	3.3	3.8	5.5	2.0	2.3	-1.5	1.8
Locomotion distance, session 3	0.8	0.9	2.9	0.3	0.6	0.1	1.7
Stereotopy head waving bouts, day 3	0.3	0.3	1.2	0.3	0.2	-0.3	-1.1
Stereotopy head waving duration, day 3	1.1	1.3	1.8	1.3	1.1	-1.4	-0.7
Locomotion velocity, session 7	0.8	0.8	1.1	0.9	0.8	-1.0	0.8
Locomotion distance, session 7	0.1	0.1	0.2	0.1	-0.1	0.1	-0.5
Stereotopy head waving bouts, day 7	4.7	5.3	6.7	2.3	2.6	-2.4	1.8
Stereotopy head waving duration, day 7	4.0	4.8	6.0	2.0	2.4	-2.4	1.9
Locomotion velocity, session 8	1.4	1.6	2.9	1.7	1.3	-1.4	-0.2
Locomotion distance, session 8	0.7	1.1	1.7	1.3	1.1	-0.9	0.8
Degree of sensitization distance	0.9	1.0	2.9	0.5	0.1	-0.8	-1.7
Degree of sensitization stereotypy	3.8	4.2	5.2	2.0	2.3	-2.1	1.8
Conditioned locomotion	0.5	0.6	0.8	0.9	0.8	-0.9	0.1
Cocaine response after cond. corrected	0.3	0.3	1.0	-0.2	-0.2	0.4	-1.0
Cocaine response after cond. not corrected	0.2	0.2	0.5	-0.3	-0.2	0.2	-0.7
Cocaine response before conditioning	0.2	0.3	1.0	-0.2	-0.0	-0.2	1.0
Saline control response	0.8	1.1	1.9	1.1	1.4	-0.8	0.7
Bone: connectivity density	0.0	0.1	0.1	0.4	0.1	-0.2	-0.3
Bone: cortical apparent density	0.9	1.2	2.9	0.7	1.1	-0.4	1.7
Bone: cortical area	0.2	0.3	0.9	-0.2	-0.5	0.2	-0.9
Bone: cortical porosity	0.2	0.2	0.4	0.1	-0.2	-0.6	-0.6
Bone: cortical porosity	0.4	0.5	1.1	0.4	0.1	-0.7	-1.1
Bone: cortical thickness	0.8	1.3	1.9	-1.2	-1.4	1.1	-0.6
Bone: cortical thickness	2.1	2.5	3.6	-1.4	-1.8	1.9	-1.1
Bone: cortical tissue density	0.9	1.2	2.7	0.7	1.1	-0.4	1.6
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.5	-0.1	0.4	-0.1
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.7	0.4	0.8	-0.4	0.8
Condit. Reinf. active responses	0.1	0.2	0.4	-0.6	-0.2	0.4	0.1
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.5	-0.3	0.2	0.2
Incentive salience index mean	0.2	0.2	0.4	-0.7	-0.3	0.5	-0.2
Condit. Reinf. lever presses	0.1	0.1	0.4	-0.6	-0.3	0.2	-0.3
Condit. Reinf. active minus inactive responses	1.0	1.4	1.9	-0.8	-1.0	1.4	-1.3
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.6	-0.3	-0.6	0.7	-1.3
Condit. Reinf. active responses	0.5	0.7	1.1	-0.5	-0.7	1.0	-1.0
Condit. Reinf. inactive responses	0.2	0.2	0.3	-0.5	-0.5	0.5	-0.1
Condit. Reinf. lever presses	0.4	0.5	0.6	-0.8	-0.8	0.6	-0.7
Condit. Reinf. lever reinforcers received	0.6	0.8	1.5	-0.6	-0.7	0.9	-1.2
Conditioned reinforcement - actives	1.6	2.8	3.8	-1.6	-1.9	1.9	-1.0
Conditioned reinforcement - inactives	3.6	5.4	7.5	-2.3	-2.7	2.1	-2.1
Conditioned locomotion	2.5	3.2	3.6	-1.6	-1.8	1.8	-1.9
Patch foraging indifference point 0 sec	0.2	0.3	0.9	-0.1	-0.1	0.5	-0.9
Patch foraging indifference point AUC	1.9	2.7	3.5	-1.7	-1.8	1.9	-1.2
Delay disc. indifference point, 0s delay	0.2	0.2	0.4	-0.6	-0.4	0.0	-0.5
Delay disc. indifference point, 16s delay	4.6	5.1	6.6	-2.6	-2.4	2.6	-1.1
Delay disc. indifference point, 2s delay	5.4	6.0	9.0	-3.0	-2.9	2.6	-0.1
Delay disc. indifference point, 24s delay	0.6	0.6	1.3	-0.6	-0.7	1.1	-0.7
Delay disc. indifference point, 4s delay	2.1	2.2	3.3	-1.8	-1.5	1.6	-0.8
Delay disc. indifference point, 8s delay	2.6	3.1	3.9	-2.0	-2.0	2.0	-0.9
Indifference point function ln k	2.4	4.2	4.8	2.2	2.2	-2.2	1.6
Indifference point function log k	2.4	4.2	4.8	2.2	2.2	-2.2	1.6
Patch foraging total patch changes 0 sec	0.2	0.5	0.7	-0.5	-0.4	0.8	-0.9
Patch foraging total patch changes 12 sec	0.8	1.0	1.6	-0.9	-0.8	1.0	-1.3
Patch foraging total patch changes 18 sec	2.0	3.0	5.0	-1.5	-1.6	1.5	-2.2
Patch foraging total patch changes 24 sec	0.5	0.8	1.5	-1.0	-1.2	0.8	-0.4
Patch foraging total patch changes 6 sec	2.0	3.1	4.0	-1.6	-1.7	1.7	-2.0
Patch foraging time to switch 0 sec	0.1	0.1	0.3	-0.3	-0.3	0.2	-0.5
Patch foraging water rate 0 sec	0.1	0.2	0.3	0.5	0.4	-0.2	-0.4
Patch foraging water rate 12 sec	0.1	0.3	0.5	0.3	0.4	-0.5	0.7
Patch foraging water rate 18 sec	0.1	0.1	0.1	0.3	0.4	-0.3	-0.4
Patch foraging water rate 24 sec	1.8	2.5	3.8	1.7	1.8	-2.0	0.4
Patch foraging water rate 6 sec	0.5	0.7	0.9	0.8	0.9	-0.8	0.8
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	-0.5	-0.3	-0.1	0.3
Distance traveled before self-admin	2.0	2.6	3.6	-1.9	-1.8	1.5	-1.1
Distance traveled after self-admin	1.3	1.6	4.8	-0.7	-0.8	0.7	-2.2
Extensor digitorum longus weight	0.5	1.8	2.8	-1.7	-1.4	1.5	-0.0
Bone: elastic displacement	0.3	0.3	0.6	0.7	0.8	-0.4	0.0
Bone: elastic work	0.4	0.5	1.4	0.5	0.3	-0.3	-1.2
Bone: endosteal estimation	0.3	0.6	1.4	0.7	0.5	-0.7	-1.2
Bone: endosteal perimeter	0.4	0.9	1.4	1.1	0.8	-1.2	-0.4
Epididymis fat weight	2.4	8.3	11.5	3.4	3.0	-3.2	1.5
Delta time in closed arm before/after self-admin	1.2	1.1	1.2	-0.9	-1.1	1.1	-1.0
Delta time in open arm before/after self-admin	0.1	0.1	0.3	-0.2	0.1	0.6	0.3
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	0.5	0.1	-0.5	0.0
Delay discount exponential model param	3.9	4.3	6.0	2.5	2.3	-2.3	0.8
Extinction: sum of active levers before priming	0.7	0.8	1.6	-1.3	-1.1	0.6	-0.2
Active lever presses in extinction session 6	0.0	0.0	0.1	-0.1	0.1	-0.0	0.3
Bone: final force	0.6	0.9	3.0	-0.3	-0.7	0.4	-1.7
Bone: final moment	0.6	1.0	3.5	-0.3	-0.6	0.4	-1.9
Food consumed during 24 hour testing period	0.2	0.3	0.9	-0.2	-0.4	0.0	-0.9
Glucose	0.1	0.1	0.2	0.3	0.1	-0.3	-0.5
Heart weight	1.3	2.0	2.8	1.6	1.5	-1.7	-0.6
Delay discount hyperbolic model param	4.1	4.6	6.5	2.6	2.4	-2.4	0.7
Intermittent access intake day 1-15 change	0.0	0.0	0.1	0.3	0.3	0.0	0.2
Intermittent access intake escalation	0.0	0.1	0.2	0.2	0.3	0.1	0.5
Intermittent access intake escalation 2	0.1	0.1	0.2	0.3	0.3	0.2	0.4
Intermitt. access day 1 inactive lever presses	0.2	0.8	2.9	-0.0	-0.4	-0.4	-1.7
Intermitt. access day 15 inactive lever presses	0.4	0.8	1.8	-0.6	-0.9	0.4	-1.3
Intermitt. access escalation Index	0.2	0.2	0.6	-0.4	-0.3	-0.3	0.7
Intermittent access day 1 total infusions	3.1	5.0	6.3	-2.2	-2.5	1.9	-2.3
Intermittent access day 15 total infusions	1.9	2.8	3.5	-1.7	-1.8	1.9	-1.2
Intermittent access terminal intake (last 3 days)	2.2	2.9	3.8	-1.7	-1.8	1.9	-1.3
Intermittent access total infusions	5.8	6.9	8.2	-2.6	-2.9	2.6	-2.4
Intermittent access day 1 locomotion	2.8	3.6	4.7	-2.0	-2.2	1.4	-1.9
Intermittent access day 15 total locomotion	0.8	1.4	2.6	-0.9	-1.3	0.6	-1.6
Intermittent access total locomotion	1.8	2.1	5.0	-1.0	-1.4	0.8	-2.2
Intermittent access standard deviation	1.5	3.2	7.2	-1.3	-1.6	1.2	-2.7
Left kidney weight	3.0	13.8	20.9	4.6	4.0	-4.2	0.1
Right kidney weight	4.0	18.3	28.1	5.3	4.7	-4.8	-0.3
Cocaine induced anxiety	0.5	0.7	1.0	1.0	0.7	-0.9	0.7
Post-drug Anxiety	1.9	2.0	2.5	1.6	1.5	-1.3	1.2
Baseline Anxiety	0.1	0.1	0.4	-0.4	-0.1	0.6	-0.0
Tail length	0.5	2.0	3.4	1.8	1.8	-1.2	0.3
Length with tail	1.6	6.8	11.0	3.3	3.1	-2.5	0.5
Length without tail	1.3	4.2	6.1	2.4	2.1	-2.5	-0.5
Times rat made contact with spout	0.1	0.1	0.2	-0.2	-0.3	0.4	-0.1
Lifetime Intake	6.7	8.1	9.6	-2.8	-3.1	2.8	-2.6
Liver weight, left	1.4	2.3	2.8	1.5	1.6	-1.3	1.7
Liver weight, right	7.7	13.5	15.4	3.9	3.9	-3.9	2.9
Locomotor activity	1.0	1.6	2.5	1.6	1.5	-1.1	0.2
Locomotor testing distance	0.0	0.1	0.1	0.3	0.3	0.1	0.1
Locomotor testing rearing	0.2	0.4	0.5	0.7	0.7	-0.6	0.1
Locomotion in novel chamber	0.6	0.7	2.6	0.1	0.4	-0.3	1.6
Locomotion in novel chamber post-restriction	0.5	0.9	1.4	-1.2	-1.0	0.8	0.7
Fecal boli incidents, locomotor time 1	1.8	2.6	5.5	-1.2	-1.2	1.3	-2.4
Change in fecal boli incidents, locomotor task	2.7	2.7	3.8	1.9	1.7	-1.3	1.5
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.5	0.5	0.3	-0.4	-1.2
Bouts of movement, locomotor time 1	0.5	0.5	0.9	0.7	0.8	-1.0	0.3
Total resting periods, locomotor time 1	0.1	0.1	0.2	0.2	0.3	-0.5	-0.3
Rest time, locomotor task time 1	0.1	0.2	0.4	0.1	-0.3	-0.4	-0.6
Distance moved, locomotor task time 1	0.9	1.4	2.1	1.2	1.2	-0.9	1.5
Vertical activity count, locomotor time 1	0.5	1.2	1.8	1.3	1.3	-1.0	0.6
Time >=10cm from walls, locomotor time 2	0.3	0.4	0.6	0.5	0.7	-0.8	-0.4
Bouts of movement, locomotor time 2	0.3	0.5	1.3	-0.6	-0.4	-0.1	1.2
Total resting periods, locomotor time 2	0.3	0.6	1.1	-1.0	-0.9	0.4	0.6
Rest time, locomotor task time 2	0.5	0.7	1.1	-0.6	-1.0	0.6	-1.0
Distance moved, locomotor task time 2	1.1	1.4	1.7	1.1	1.3	-1.2	1.1
Vertical activity count, locomotor time 2	0.8	1.1	1.7	1.1	1.1	-1.3	0.2
Light reinforcement 1	0.1	0.2	0.4	-0.6	-0.5	0.4	-0.4
Light reinforcement 2	0.7	1.0	1.7	0.6	0.9	-1.3	1.1
Bone: marrow area	0.3	0.7	1.5	0.7	0.5	-0.7	-1.2
Bone: maximum diameter	0.3	0.6	1.0	0.8	0.5	-0.7	-1.0
Bone: maximum force	0.8	1.4	4.5	-0.4	-0.9	0.6	-2.1
Bone: maximum moment	0.8	1.5	4.9	-0.3	-0.8	0.5	-2.2
Mean time between licks in bursts	0.3	0.7	1.4	-1.1	-0.5	1.2	0.1
Mean num. licks in bursts	0.5	0.8	1.2	1.1	0.9	-1.1	0.3
Cd content in liver	0.5	0.5	0.8	0.9	0.8	-0.4	0.6
Co content in liver	1.0	1.2	1.8	-1.1	-0.9	1.3	-0.9
Cu content in liver	2.5	2.9	4.2	-2.0	-1.9	2.0	-0.4
Fe content in liver	1.9	2.3	3.1	1.7	1.8	-1.6	-0.9
K content in liver	0.0	0.0	0.1	-0.1	-0.2	0.4	-0.1
Mg content in liver	0.1	0.1	0.2	-0.1	-0.4	0.3	-0.4
Mn content in liver	0.1	0.1	0.4	-0.1	-0.1	-0.2	0.6
Na content in liver	0.1	0.1	0.2	-0.0	-0.0	0.0	-0.5
Rb content in liver	0.8	0.9	1.2	-0.8	-0.9	1.1	-1.1
Se content in liver	0.4	0.5	1.6	0.4	0.5	-0.2	1.3
Sr content in liver	1.4	1.2	1.7	-1.3	-1.3	1.0	0.7
Zn content in liver	0.1	0.1	0.2	0.4	0.2	0.1	0.4
Bone: minimum diameter	0.1	0.3	0.9	-0.1	-0.4	-0.1	-0.9
Time in familiar zone, hab. session 1	0.2	0.2	0.3	-0.3	-0.4	0.6	-0.4
Time in novel zone, hab. session 1	1.0	1.0	1.5	1.1	1.1	-1.2	0.4
Total zone transitions, hab. session 1	0.6	0.8	1.8	-0.6	-0.3	1.3	1.0
Total locomotion distance, hab. session 1	0.4	0.6	1.7	0.4	0.5	0.2	1.3
Locomotion velocity, hab. session 1	0.2	0.3	0.8	-0.1	-0.0	0.6	0.9
Time in familiar zone, hab. session 2	0.7	0.8	2.2	0.5	0.6	-0.5	1.5
Time in novel zone, hab. session 2	0.7	0.8	2.2	-0.5	-0.7	0.4	-1.5
Total zone transitions, hab. session 2	1.9	2.4	3.6	-1.4	-1.4	1.9	-1.4
Total locomotion distance, hab. session 2	2.0	2.6	3.0	-1.5	-1.5	1.7	-1.6
Locomotion velocity, hab. session 2	2.4	3.2	4.0	-1.7	-1.7	2.0	-1.8
Novel to familiar place preference ratio	3.1	3.4	4.7	2.2	2.1	-1.8	1.0
Novelty place preference	4.5	4.8	6.3	2.5	2.5	-2.2	1.4
Time in novel zone, NPP test	5.3	5.7	7.5	2.7	2.7	-2.4	1.5
Total zone transitions, NPP test	1.1	1.6	3.9	-1.2	-1.0	2.0	-0.1
Total locomotion distance, NPP test	0.8	1.0	2.2	-1.0	-0.8	1.5	-0.7
Locomotion velocity, NPP test	1.2	1.7	3.1	-1.5	-1.1	1.8	-0.6
Intraocular pressure	0.3	0.4	0.6	0.8	0.6	-0.7	0.4
Delta distance traveled before/after self-admin	1.7	1.8	2.9	1.7	1.4	-1.4	-0.7
Delta ambulatory time before/after self-admin	1.1	1.4	1.9	1.4	1.2	-0.9	-1.1
Parametrial fat weight	1.5	3.6	5.2	1.8	2.0	-2.3	1.5
Pavlov. Cond. lever latency	0.1	0.1	0.3	0.6	0.4	-0.1	0.1
Pavlov. Cond. magazine entry latency	1.6	2.0	2.8	-1.7	-1.7	1.3	-0.8
Pavlov. Cond. change in total contacts	3.8	4.1	5.6	-2.4	-2.3	1.9	-1.4
Pavlov. Cond. index score	0.9	1.1	1.5	-1.2	-1.2	0.8	-0.9
Pavlov. Cond. latency score	0.5	0.6	0.9	-0.9	-0.9	0.5	-0.6
Pavlov. Cond. lever contacts	0.7	0.8	1.4	-1.2	-1.1	0.6	-0.5
Pavlov. Cond. magazine entry number	1.7	2.2	3.0	1.7	1.7	-1.5	0.8
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.7	-0.5	-0.2	0.8	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.5	-1.2	-1.2	0.8	-0.6
Pavlov. Cond. response bias	1.5	1.9	2.8	-1.7	-1.7	1.2	-0.8
Pavlov. Cond. lever latency	0.2	0.2	0.6	0.4	0.3	-0.1	0.8
Pavlov. Cond. magazine entry latency	2.8	3.4	3.4	-1.9	-1.8	1.8	-1.8
Pavlov. Cond. change in total contacts	1.1	1.8	6.7	-0.4	-0.5	0.3	-2.6
Pavlov. Cond. index score	1.0	1.3	2.5	-1.0	-0.9	0.9	-1.6
Pavlov. Cond. latency score	1.3	1.7	2.7	-1.2	-1.1	1.2	-1.7
Pavlov. Cond. lever contacts	0.1	0.2	0.6	-0.3	-0.2	0.0	-0.8
Pavlov. Cond. magazine entry number	0.8	0.9	1.7	0.8	0.8	-0.9	1.3
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	0.1	-0.2	-0.4	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	2.2	-1.0	-0.9	0.9	-1.5
Pavlov. Cond. response bias	0.7	1.0	2.1	-0.9	-0.9	0.6	-1.4
Time in closed arm before self-admin	0.9	1.1	1.6	-1.3	-1.2	0.9	-0.9
Time in closed arm after self-admin	0.2	0.2	0.7	-0.1	-0.4	-0.1	-0.9
Time in open arm before self-admin	0.3	0.4	0.5	0.7	0.5	-0.7	0.4
Time in open arm after self-admin	0.4	0.5	1.4	0.4	0.6	-0.0	1.2
Bone: periosteal estimation	0.2	0.5	1.6	0.3	0.1	-0.4	-1.2
Bone: periosteal perimeter	0.6	1.1	1.7	1.3	0.9	-1.2	-0.6
Bone: post-yield work	0.9	1.4	1.9	-1.0	-1.2	1.1	-1.4
Progressive ratio test 1 active lever presses	4.0	4.9	6.0	-2.3	-2.5	1.9	-2.1
Progressive ratio test 1 breakpoint	3.7	4.6	5.5	-2.2	-2.3	1.9	-2.0
Progressive ratio test 1 inactive lever presses	5.2	7.5	9.1	-2.7	-3.0	2.4	-2.7
Progressive ratio test 2 active lever presses	3.5	4.1	5.4	-2.0	-2.3	1.9	-1.8
Progressive ratio test 2 breakpoint	3.8	4.4	5.8	-2.1	-2.4	2.0	-1.7
Progressive ratio test 2 inactive lever presses	2.2	3.6	5.2	-2.0	-2.3	1.8	-1.4
Incentive Sensitization - Responses	0.3	0.4	0.6	-0.6	-0.8	0.6	-0.3
Incentive Sensitization - Breakpoint	0.3	0.3	0.6	-0.6	-0.8	0.6	-0.3
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	0.3	0.3	-0.7	0.4
Progressive ratio	0.2	0.3	0.7	-0.3	-0.3	0.4	-0.8
Food seeking constrained by brief footshock	0.2	0.3	0.7	-0.4	-0.5	0.9	0.0
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.3	-0.4	0.3	0.1
Retroperitoneal fat weight	2.7	11.5	16.9	3.7	3.6	-4.1	1.6
Reaction time number correct	0.5	0.9	2.9	0.3	0.5	-0.5	1.7
Reaction time mean minus median	0.0	0.0	0.0	0.1	0.0	-0.0	-0.1
Reaction time mean minus median AUC	0.2	0.4	0.6	0.8	0.6	-0.8	0.4
Reaction time num false alarms	0.2	0.3	0.4	0.5	0.5	-0.6	0.5
Reaction time num false alarms AUC	0.2	0.3	0.5	0.4	0.6	-0.5	0.7
Reaction time trials correct on left	0.5	0.9	2.9	0.3	0.5	-0.5	1.7
Reaction time trials on left	0.5	0.9	2.9	0.2	0.4	-0.5	1.7
Reaction time mean	0.1	0.1	0.3	0.6	0.4	-0.2	-0.2
Reaction time mean AUC	0.1	0.1	0.3	0.6	0.3	-0.2	-0.1
Median of all reaction times	0.1	0.1	0.3	0.5	0.3	-0.1	-0.2
Reaction time omissions	0.7	1.0	1.4	-1.2	-1.2	1.1	-0.1
Reaction time false alarm rate	0.1	0.1	0.1	0.3	0.4	-0.3	0.1
Reaction time premature initiation rate	0.8	1.1	3.0	-0.6	-1.0	0.3	-1.7
Reaction time premature initiations	0.1	0.3	0.6	-0.3	-0.6	-0.2	-0.8
Std. dev. reaction times	0.2	0.4	0.7	0.9	0.6	-0.7	0.0
Reaction time trials completed	0.5	0.9	2.9	0.2	0.4	-0.5	1.7
Reaction time trials AUC	0.5	0.9	2.7	0.4	0.5	-0.7	1.6
Run reversals in cocaine runway, females	0.9	0.9	1.2	0.9	1.1	-0.6	1.1
Run reversals in cocaine runway, males	0.2	0.2	0.6	0.4	0.3	0.8	0.0
Latency to leave start box in cocaine runway	0.3	0.3	0.5	0.3	0.6	-0.7	0.6
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	-0.6	-0.2	0.7	-0.1
Latency to leave start box in cocaine runway, M	2.7	2.5	4.7	1.5	1.4	-2.2	1.2
Std. dev. time between licks in bursts	0.6	0.8	1.2	-0.7	-0.3	1.1	-1.1
Total sessions with >9 infusions	2.5	3.0	3.9	-1.6	-1.8	1.6	-2.0
Short access day 1 total inactive lever presses	4.1	5.4	14.4	-1.3	-1.6	1.7	-3.8
Short access day 10 total inactive lever presses	0.5	1.2	1.9	1.3	0.9	-1.4	-0.5
Short access day 1 total infusions	1.8	2.4	4.5	-1.3	-1.4	1.4	-2.1
Short access day 10 total infusions	1.8	2.4	3.0	-1.5	-1.7	1.2	-1.7
Short access total infusions	4.0	5.1	6.1	-2.2	-2.5	2.0	-2.4
Short access day 1 locomotion	1.0	1.2	2.4	-0.8	-0.9	1.0	-1.5
Short access day 10 total locomotion	1.2	2.3	4.3	-1.4	-1.6	0.5	-2.1
Short access total locomotion	1.9	2.2	3.6	-1.4	-1.5	1.0	-1.9
One hour access (0.3 mA shock)	6.7	7.8	10.6	-3.2	-3.3	2.9	-1.4
Compulsive drug intake	0.1	0.1	0.2	-0.3	-0.4	0.3	0.5
One hour access (shock baseline)	2.0	3.1	4.2	-2.0	-2.0	1.7	-1.1
Social response proportion	0.3	0.4	0.6	-0.7	-0.5	0.4	-0.8
Social responses	1.3	1.7	2.8	-1.3	-1.2	1.7	-0.9
Social time	3.8	5.2	7.3	-2.4	-2.3	2.7	-1.6
Soleus weight	0.4	1.1	1.4	-0.7	-1.2	1.0	-1.1
Bone: stiffness	0.5	0.9	3.3	-0.2	-0.5	0.0	-1.8
Tibialis anterior weight	2.0	6.8	9.2	-3.0	-2.9	3.0	-0.8
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	0.2	-0.1	-0.5	-0.4
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.7	0.7	0.8	-0.8	-0.2
Time to tail flick, test, before self-admin	0.6	0.6	1.2	-0.5	-0.5	0.9	1.1
Time to tail flick, test, after self-admin	0.0	0.0	0.0	-0.0	0.1	0.0	0.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.8	-0.5	-0.1	0.7	-0.9
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.2	0.4	-0.4	0.0
Tibia length	0.1	0.3	0.6	0.7	0.4	-0.3	-0.8
Ambulatory time before self-admin	1.1	1.6	2.2	-1.5	-1.4	1.4	-0.6
Ambulatory time after self-admin	0.9	1.0	3.1	-0.4	-0.4	0.8	-1.8
Bone: tissue strength	0.4	0.4	0.6	0.8	0.6	-0.7	0.2
Total heroin consumption	1.0	1.2	1.8	-1.3	-1.1	1.1	-0.7
Bone: trabecular number	0.3	0.5	0.7	0.7	0.7	-0.6	0.8
Bone: trabecular spacing	0.5	0.7	2.6	-0.1	-0.5	0.2	-1.6
Bone: trabecular thickness	0.3	0.3	0.9	0.1	0.2	-0.7	0.9
Bone: trabecular tissue density	0.0	0.0	0.1	-0.2	0.1	0.3	0.1
Water consumed over 24 hours	0.2	0.3	0.8	-0.2	-0.3	0.5	-0.9
Number of responses in last shaping day	8.0	8.8	10.1	-3.2	-3.2	2.7	-2.7