Hub : Genes

Gsta2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr8_88074695_88077052	0.03	0.02	3.7e-03	0.02	0.02	0.01	0.02	4.3e-03	3.6e-03	8.0e-03	5.2e-03
2	Adipose	gene expression	Gsta2	0.02	0.01	3.0e-03	0.01	0.02	0.01	0.01	2.6e-02	4.6e-03	9.5e-03	2.0e-02
3	Liver	gene expression	Gsta2	0.78	0.05	0.0e+00	0.62	0.64	0.65	0.65	9.1e-89	1.4e-91	9.8e-96	9.6e-96
4	Liver	mRNA stability	Gsta2	0.26	0.12	0.0e+00	0.25	0.26	0.27	0.26	4.3e-27	2.7e-28	5.9e-30	1.3e-28

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.5	0.8	1.1	-1.0	-0.9	-1.1	0.4
Area under the delay curve	1.9	2.2	3.5	0.9	1.1	1.9	-1.7
BMI with tail	5.6	19.4	27.1	-5.2	-4.8	-4.1	3.3
BMI without tail	1.4	4.3	7.5	-2.7	-2.3	-1.9	1.2
Body weight	1.8	8.0	13.0	-3.6	-2.9	-2.8	1.6
Weight adjusted by age	0.2	0.3	0.9	-1.0	-0.5	-0.3	-0.2
Bone surface	3.6	6.5	8.0	-2.8	-2.6	-2.8	1.8
Bone volume	1.5	2.7	3.6	-1.9	-1.7	-1.9	0.9
Breakpoint value in progressive ratio session	1.3	1.5	2.3	-0.9	-1.1	-1.3	1.5
Number of licking bursts	0.3	0.5	0.8	-0.9	-0.9	-0.5	0.4
Context. condit. distance diff. score	0.1	0.1	0.4	-0.7	-0.1	-0.2	-0.3
Locomotion velocity, session 1	1.1	1.2	1.4	1.1	1.2	1.2	-0.9
Locomotion distance, session 1	1.0	1.3	1.5	1.0	1.2	1.1	-1.2
Locomotion velocity, session 2	1.0	1.1	1.5	1.2	1.0	1.1	-0.8
Locomotion distance, session 2	1.7	2.4	2.9	1.7	1.6	1.5	-1.3
Locomotion velocity, session 3	0.1	0.1	0.2	-0.4	-0.4	-0.4	0.2
Locomotion distance, session 3	0.3	0.3	0.7	0.8	0.6	0.3	0.1
Stereotopy head waving bouts, day 3	2.2	2.6	3.3	-1.2	-1.8	-1.6	1.8
Stereotopy head waving duration, day 3	1.4	1.6	1.9	-1.1	-1.4	-1.4	1.2
Locomotion velocity, session 7	0.2	0.2	0.4	-0.6	-0.5	-0.2	0.2
Locomotion distance, session 7	0.0	0.0	0.1	0.1	0.2	0.3	-0.2
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	-0.2	0.1	0.5	-0.5
Stereotopy head waving duration, day 7	0.1	0.1	0.4	-0.6	-0.2	0.2	-0.3
Locomotion velocity, session 8	0.2	0.3	0.4	-0.6	-0.5	-0.6	0.3
Locomotion distance, session 8	0.6	0.9	1.0	0.7	1.0	1.0	-1.0
Degree of sensitization distance	0.1	0.1	0.5	-0.2	0.1	0.2	-0.7
Degree of sensitization stereotypy	0.3	0.4	0.6	0.0	0.4	0.8	-0.8
Conditioned locomotion	0.9	1.0	1.7	1.2	0.9	1.3	-0.1
Cocaine response after cond. corrected	0.0	0.0	0.1	-0.3	-0.1	0.1	0.2
Cocaine response after cond. not corrected	0.1	0.1	0.3	-0.6	-0.2	0.1	0.2
Cocaine response before conditioning	0.1	0.1	0.3	-0.6	-0.0	0.0	-0.0
Saline control response	0.6	0.8	1.6	-1.3	-0.9	-0.7	0.3
Bone: connectivity density	0.9	1.4	2.1	-1.0	-1.1	-1.4	1.1
Bone: cortical apparent density	1.7	2.3	3.1	1.7	1.6	1.6	-0.8
Bone: cortical area	0.3	0.5	1.0	-0.5	-0.8	-1.0	0.4
Bone: cortical porosity	0.0	0.0	0.2	-0.0	0.1	0.4	-0.1
Bone: cortical porosity	0.0	0.0	0.0	-0.1	-0.0	0.2	0.1
Bone: cortical thickness	1.3	2.2	3.7	1.9	1.5	1.4	-0.9
Bone: cortical thickness	0.0	0.0	0.0	0.0	-0.0	0.1	0.1
Bone: cortical tissue density	1.6	2.2	2.9	1.7	1.6	1.6	-0.9
Condit. Reinf. active minus inactive responses	1.1	1.2	2.0	0.8	1.1	1.4	-1.0
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.4	0.0	0.1	-0.3
Condit. Reinf. active responses	0.5	0.6	0.9	0.7	0.7	0.9	-0.7
Condit. Reinf. inactive responses	0.2	0.3	0.7	0.8	0.5	0.4	-0.2
Incentive salience index mean	0.9	1.2	1.8	0.7	1.1	1.3	-1.1
Condit. Reinf. lever presses	0.4	0.6	0.8	0.5	0.7	0.9	-0.9
Condit. Reinf. active minus inactive responses	0.4	0.5	0.9	-0.8	-0.7	-1.0	0.3
Condit. Reinf. active-inactive response ratio	3.1	3.5	4.1	-1.9	-2.0	-2.0	1.6
Condit. Reinf. active responses	0.1	0.1	0.2	-0.2	-0.1	-0.4	-0.4
Condit. Reinf. inactive responses	1.6	2.1	3.2	1.3	1.5	1.1	-1.8
Condit. Reinf. lever presses	0.1	0.2	0.6	-0.1	0.1	-0.3	-0.8
Condit. Reinf. lever reinforcers received	0.1	0.1	0.3	0.2	0.2	-0.3	-0.5
Conditioned reinforcement - actives	0.8	1.4	1.8	-1.2	-1.3	-0.9	1.3
Conditioned reinforcement - inactives	0.3	0.4	0.5	0.7	0.6	0.7	-0.7
Conditioned locomotion	0.1	0.1	0.3	-0.4	-0.2	0.2	0.5
Patch foraging indifference point 0 sec	0.2	0.3	0.8	-0.2	-0.4	-0.9	0.6
Patch foraging indifference point AUC	1.1	1.6	3.3	0.9	1.3	0.9	-1.8
Delay disc. indifference point, 0s delay	1.8	2.0	2.3	1.4	1.5	1.5	-1.2
Delay disc. indifference point, 16s delay	6.7	7.4	11.7	2.3	2.4	3.4	-2.6
Delay disc. indifference point, 2s delay	0.2	0.2	0.4	-0.6	-0.6	-0.1	-0.5
Delay disc. indifference point, 24s delay	2.4	2.7	4.2	1.2	1.3	2.0	-1.9
Delay disc. indifference point, 4s delay	0.4	0.4	0.8	0.1	0.3	0.8	-0.9
Delay disc. indifference point, 8s delay	0.7	0.8	1.4	0.4	0.7	1.2	-1.1
Indifference point function ln k	0.8	1.4	1.7	-1.2	-1.1	-1.0	1.3
Indifference point function log k	0.8	1.4	1.7	-1.2	-1.1	-1.0	1.3
Patch foraging total patch changes 0 sec	0.1	0.2	0.5	-0.0	-0.3	-0.7	0.6
Patch foraging total patch changes 12 sec	1.6	2.0	3.1	1.4	1.6	0.8	-1.8
Patch foraging total patch changes 18 sec	0.1	0.2	0.3	-0.4	-0.3	-0.6	0.3
Patch foraging total patch changes 24 sec	0.0	0.1	0.2	0.4	0.4	0.1	0.1
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	0.6	0.4	-0.1	-0.2
Patch foraging time to switch 0 sec	1.1	2.3	3.8	-1.1	-1.7	-1.1	2.0
Patch foraging water rate 0 sec	0.1	0.3	0.8	-0.1	0.5	0.1	-0.9
Patch foraging water rate 12 sec	0.5	1.0	2.8	0.4	0.7	0.7	-1.7
Patch foraging water rate 18 sec	0.5	0.7	1.6	0.4	0.8	0.7	-1.3
Patch foraging water rate 24 sec	0.0	0.0	0.0	0.1	0.0	-0.1	-0.2
Patch foraging water rate 6 sec	0.5	0.8	1.8	-0.1	0.5	1.0	-1.3
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.6	0.1	0.2	0.3	-0.8
Distance traveled before self-admin	1.0	1.3	1.7	-1.3	-1.3	-1.1	0.7
Distance traveled after self-admin	1.9	2.4	2.9	-1.7	-1.6	-1.3	1.5
Extensor digitorum longus weight	0.4	1.7	4.4	-2.1	-1.2	-0.9	-0.1
Bone: elastic displacement	0.4	0.5	0.7	0.3	0.8	0.8	-0.7
Bone: elastic work	0.1	0.1	0.3	-0.5	-0.3	-0.5	-0.1
Bone: endosteal estimation	6.6	14.4	18.2	-4.3	-4.0	-4.1	2.7
Bone: endosteal perimeter	3.8	8.2	9.6	-3.1	-3.1	-3.0	2.1
Epididymis fat weight	0.1	0.5	1.3	1.2	0.5	0.1	0.5
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.1	0.0	0.0	0.2
Delta time in open arm before/after self-admin	1.7	1.7	2.8	-0.5	-1.2	-1.7	1.4
Diff in mean of infusions in LGA sessions	0.9	1.2	1.5	-1.2	-1.1	-0.8	1.1
Delay discount exponential model param	1.7	1.8	3.1	-0.7	-0.9	-1.7	1.8
Extinction: sum of active levers before priming	1.3	1.4	2.1	-0.8	-1.4	-1.1	1.4
Active lever presses in extinction session 6	0.1	0.1	0.2	0.1	0.3	0.4	-0.2
Bone: final force	0.0	0.0	0.1	0.2	0.1	-0.1	-0.3
Bone: final moment	0.0	0.1	0.2	0.3	0.2	-0.1	-0.4
Food consumed during 24 hour testing period	1.4	2.0	4.0	-2.0	-1.3	-1.2	0.7
Glucose	1.6	2.4	4.1	-1.2	-1.5	-1.4	2.0
Heart weight	0.1	0.1	0.4	-0.2	0.2	0.7	-0.1
Delay discount hyperbolic model param	1.4	1.5	2.7	-0.5	-0.8	-1.6	1.6
Intermittent access intake day 1-15 change	0.1	0.2	0.5	0.7	0.2	0.5	-0.1
Intermittent access intake escalation	0.2	0.3	0.7	0.8	0.4	0.6	-0.3
Intermittent access intake escalation 2	0.1	0.1	0.2	0.4	0.2	0.5	-0.1
Intermitt. access day 1 inactive lever presses	0.3	1.1	1.6	0.9	1.1	0.9	-1.3
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.3	0.6	0.3	0.1	-0.1
Intermitt. access escalation Index	0.2	0.3	0.8	-0.2	0.4	0.9	-0.3
Intermittent access day 1 total infusions	1.5	2.4	3.7	-1.4	-1.6	-1.2	1.9
Intermittent access day 15 total infusions	0.8	1.2	2.4	-0.7	-1.2	-0.7	1.6
Intermittent access terminal intake (last 3 days)	1.2	1.6	2.6	-1.2	-1.3	-0.6	1.6
Intermittent access total infusions	1.6	1.8	2.6	-1.3	-1.4	-1.1	1.6
Intermittent access day 1 locomotion	0.8	1.0	1.3	-0.9	-1.1	-0.8	1.2
Intermittent access day 15 total locomotion	0.0	0.1	0.2	0.3	0.1	0.5	0.2
Intermittent access total locomotion	0.6	0.7	0.8	-0.8	-0.9	-0.8	0.8
Intermittent access standard deviation	0.1	0.2	0.3	0.6	0.2	0.2	0.5
Left kidney weight	0.1	0.6	1.1	-1.1	-0.6	-0.8	-0.4
Right kidney weight	0.1	0.5	0.9	-1.0	-0.4	-0.5	-0.7
Cocaine induced anxiety	1.3	1.8	2.6	-1.4	-1.6	-1.1	1.2
Post-drug Anxiety	0.2	0.3	0.4	-0.5	-0.6	-0.6	0.2
Baseline Anxiety	2.9	3.3	4.6	2.0	2.1	1.3	-1.8
Tail length	1.5	5.8	6.6	2.4	2.6	2.1	-2.6
Length with tail	0.3	1.5	3.1	0.9	1.3	0.6	-1.8
Length without tail	0.1	0.4	1.0	-1.0	-0.5	-0.7	-0.3
Times rat made contact with spout	0.3	0.3	1.0	0.2	0.5	0.4	-1.0
Lifetime Intake	1.6	2.0	2.5	-1.3	-1.5	-1.2	1.6
Liver weight, left	0.3	0.4	0.6	-0.8	-0.8	-0.6	0.3
Liver weight, right	0.2	0.4	0.9	-0.4	-0.8	-0.9	0.2
Locomotor activity	0.0	0.0	0.1	-0.0	0.1	-0.3	0.0
Locomotor testing distance	0.0	0.0	0.0	-0.0	0.1	0.0	-0.1
Locomotor testing rearing	0.1	0.2	0.4	-0.3	-0.5	-0.7	0.4
Locomotion in novel chamber	1.1	1.4	1.8	1.2	1.0	1.3	-1.2
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	-0.5	-0.1	-0.2	0.3
Fecal boli incidents, locomotor time 1	0.4	0.6	1.3	-1.2	-1.0	-0.4	0.4
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	0.2	-0.1	-0.6	-0.3
Time >=10cm from walls, locomotor time 1	1.7	1.8	2.6	-1.6	-1.5	-0.8	1.3
Bouts of movement, locomotor time 1	10.3	11.8	14.6	3.4	3.4	3.8	-3.1
Total resting periods, locomotor time 1	8.7	9.7	11.9	3.0	3.0	3.4	-2.9
Rest time, locomotor task time 1	2.0	2.5	3.8	1.5	1.3	2.0	-1.5
Distance moved, locomotor task time 1	0.0	0.1	0.1	-0.2	0.0	-0.3	0.3
Vertical activity count, locomotor time 1	0.0	0.1	0.1	-0.2	-0.2	-0.4	0.3
Time >=10cm from walls, locomotor time 2	0.4	0.5	1.0	-0.7	-1.0	-0.5	0.6
Bouts of movement, locomotor time 2	4.0	6.4	7.6	2.8	2.7	2.7	-1.9
Total resting periods, locomotor time 2	3.7	6.5	7.8	2.7	2.7	2.8	-1.9
Rest time, locomotor task time 2	3.1	4.0	4.9	2.2	1.9	2.2	-1.6
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.0	0.2	-0.3	-0.3
Vertical activity count, locomotor time 2	0.5	0.7	1.3	-1.1	-0.8	-0.9	0.4
Light reinforcement 1	0.8	1.9	3.3	1.2	1.4	1.8	-1.1
Light reinforcement 2	0.0	0.0	0.0	0.0	0.2	0.1	-0.2
Bone: marrow area	6.6	14.4	18.2	-4.3	-4.0	-4.0	2.6
Bone: maximum diameter	2.9	5.5	7.3	-2.7	-2.5	-2.5	1.3
Bone: maximum force	0.1	0.2	0.4	-0.5	-0.4	-0.6	-0.1
Bone: maximum moment	0.1	0.2	0.3	-0.4	-0.3	-0.6	-0.2
Mean time between licks in bursts	0.3	0.6	0.9	0.8	1.0	0.8	-0.6
Mean num. licks in bursts	0.5	0.8	1.1	0.8	1.0	0.8	-1.0
Cd content in liver	0.2	0.2	0.9	0.3	-0.2	-0.1	0.9
Co content in liver	2.9	3.4	4.2	1.8	1.9	2.0	-1.6
Cu content in liver	0.0	0.0	0.0	0.1	0.1	-0.1	-0.2
Fe content in liver	0.0	0.1	0.1	0.2	0.1	-0.3	-0.3
K content in liver	0.1	0.1	0.1	-0.4	-0.1	-0.4	0.1
Mg content in liver	0.6	0.6	1.0	-0.9	-0.6	-1.0	0.3
Mn content in liver	0.2	0.3	0.4	-0.6	-0.5	-0.6	0.2
Na content in liver	0.3	0.3	0.6	-0.7	-0.6	-0.8	-0.0
Rb content in liver	0.3	0.3	0.8	-0.1	-0.4	-0.9	0.6
Se content in liver	0.6	0.7	1.4	-0.5	-0.7	-1.2	0.9
Sr content in liver	0.1	0.1	0.3	0.6	0.2	0.1	0.3
Zn content in liver	1.9	2.1	3.1	-1.4	-1.4	-1.1	1.8
Bone: minimum diameter	0.6	1.1	1.9	-0.8	-1.1	-1.4	0.8
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.0	-0.1	-0.3	-0.1
Time in novel zone, hab. session 1	0.1	0.1	0.4	0.0	0.3	0.7	-0.2
Total zone transitions, hab. session 1	2.1	2.9	4.8	2.2	1.7	1.6	-1.1
Total locomotion distance, hab. session 1	3.6	5.1	8.4	2.9	2.3	2.1	-1.6
Locomotion velocity, hab. session 1	3.5	4.9	8.1	2.9	2.3	2.0	-1.6
Time in familiar zone, hab. session 2	0.8	0.9	1.3	0.8	1.0	0.8	-1.2
Time in novel zone, hab. session 2	2.7	2.7	3.3	-1.7	-1.8	-1.4	1.6
Total zone transitions, hab. session 2	3.5	4.5	5.3	2.3	2.3	1.9	-2.0
Total locomotion distance, hab. session 2	6.1	8.0	10.8	3.3	3.1	2.7	-2.1
Locomotion velocity, hab. session 2	6.0	8.0	11.3	3.4	3.1	2.6	-2.0
Novel to familiar place preference ratio	0.5	0.5	1.3	-0.1	0.6	1.1	-0.7
Novelty place preference	0.3	0.3	0.6	-0.6	0.2	0.8	-0.4
Time in novel zone, NPP test	0.3	0.3	0.9	-0.9	-0.1	0.6	-0.2
Total zone transitions, NPP test	2.8	4.1	5.1	2.3	2.2	1.9	-1.6
Total locomotion distance, NPP test	3.1	4.2	5.8	2.4	2.2	2.1	-1.3
Locomotion velocity, NPP test	3.2	4.5	7.4	2.7	2.3	1.9	-1.2
Intraocular pressure	0.6	0.9	1.3	-0.8	-1.0	-1.1	0.7
Delta distance traveled before/after self-admin	0.2	0.2	0.5	-0.4	-0.3	-0.2	0.7
Delta ambulatory time before/after self-admin	0.6	0.7	1.4	-0.9	-0.7	-0.6	1.2
Parametrial fat weight	0.4	0.9	1.1	-0.8	-1.0	-0.9	1.0
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.3	-0.3	-0.5	0.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.1	0.1	0.4	0.5
Pavlov. Cond. change in total contacts	0.4	0.4	0.7	0.7	0.6	0.8	-0.1
Pavlov. Cond. index score	0.0	0.0	0.2	0.1	0.1	0.4	0.1
Pavlov. Cond. latency score	0.1	0.1	0.4	0.3	0.3	0.6	-0.1
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.0	-0.0	0.2	0.3
Pavlov. Cond. magazine entry number	0.0	0.0	0.2	0.1	0.1	-0.1	-0.4
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.8	-0.5	-0.7	-0.9	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	0.0	0.1	0.5	0.0
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.2	-0.2	0.1	0.5
Pavlov. Cond. lever latency	0.3	0.4	1.1	0.6	0.5	1.0	0.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.5	0.7	0.1	-0.1	-0.3
Pavlov. Cond. change in total contacts	0.2	0.3	1.1	-0.1	-0.3	-1.0	-0.4
Pavlov. Cond. index score	0.3	0.4	1.2	-0.3	-0.6	-1.1	0.0
Pavlov. Cond. latency score	0.3	0.4	1.3	-0.3	-0.6	-1.1	0.0
Pavlov. Cond. lever contacts	0.5	0.7	1.4	-0.8	-0.8	-1.2	-0.2
Pavlov. Cond. magazine entry number	0.9	1.2	2.4	0.5	1.2	1.6	-0.7
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.1	0.4	0.2	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.7	-0.1	-0.4	-0.8	-0.3
Pavlov. Cond. response bias	0.3	0.4	1.0	-0.5	-0.6	-1.0	-0.2
Time in closed arm before self-admin	1.7	2.2	3.2	-1.8	-1.5	-1.6	1.0
Time in closed arm after self-admin	0.0	0.0	0.1	0.1	0.3	-0.2	0.1
Time in open arm before self-admin	0.7	0.8	2.0	0.6	0.9	1.4	-0.4
Time in open arm after self-admin	3.4	3.7	4.7	-1.6	-2.1	-1.9	2.2
Bone: periosteal estimation	4.6	9.8	11.9	-3.3	-3.3	-3.5	2.2
Bone: periosteal perimeter	2.8	4.8	6.1	-2.3	-2.4	-2.5	1.5
Bone: post-yield work	0.3	0.5	1.1	-1.1	-0.7	-0.5	-0.0
Progressive ratio test 1 active lever presses	1.3	1.6	2.0	-1.4	-1.3	-1.0	1.3
Progressive ratio test 1 breakpoint	1.4	1.7	2.1	-1.5	-1.4	-1.1	1.3
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.8	-0.2	-0.4	-0.9	-0.0
Progressive ratio test 2 active lever presses	0.1	0.2	0.3	-0.3	-0.4	-0.5	0.3
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	-0.2	-0.2	-0.4	0.1
Progressive ratio test 2 inactive lever presses	0.9	1.5	2.1	-0.9	-1.2	-1.4	1.2
Incentive Sensitization - Responses	0.1	0.2	0.4	0.6	0.5	0.0	-0.5
Incentive Sensitization - Breakpoint	0.3	0.4	0.7	0.8	0.7	0.3	-0.7
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.2	-0.5	-0.0	0.4
Progressive ratio	0.1	0.1	0.4	-0.2	0.1	0.6	0.3
Food seeking constrained by brief footshock	0.2	0.3	0.9	-0.5	-0.2	0.2	-1.0
Seeking ratio, punishment vs. effort	0.2	0.2	0.7	0.0	-0.0	-0.6	-0.8
Retroperitoneal fat weight	0.1	0.3	1.0	1.0	0.3	-0.1	-0.1
Reaction time number correct	0.1	0.2	0.3	0.2	0.4	0.6	-0.4
Reaction time mean minus median	0.3	0.8	1.3	-0.5	-0.9	-0.9	1.2
Reaction time mean minus median AUC	0.4	0.9	2.0	-0.5	-0.9	-0.8	1.4
Reaction time num false alarms	0.4	0.5	0.9	0.3	-0.5	-0.9	0.9
Reaction time num false alarms AUC	0.4	0.6	1.1	0.1	-0.7	-1.1	1.0
Reaction time trials correct on left	0.1	0.2	0.3	0.2	0.4	0.6	-0.4
Reaction time trials on left	0.1	0.1	0.3	0.1	0.4	0.5	-0.3
Reaction time mean	0.6	1.0	1.5	-0.5	-1.0	-1.0	1.2
Reaction time mean AUC	0.7	1.1	1.5	-0.6	-1.1	-1.1	1.2
Median of all reaction times	0.3	0.5	0.8	-0.2	-0.7	-0.7	0.9
Reaction time omissions	0.1	0.2	0.4	0.5	0.6	0.3	-0.2
Reaction time false alarm rate	0.5	0.7	1.2	0.1	-0.7	-1.1	1.0
Reaction time premature initiation rate	0.1	0.1	0.4	-0.6	-0.3	-0.1	0.3
Reaction time premature initiations	0.1	0.1	0.3	-0.5	-0.2	0.0	0.2
Std. dev. reaction times	0.7	1.4	2.1	-0.8	-1.1	-1.3	1.4
Reaction time trials completed	0.1	0.1	0.3	0.1	0.4	0.5	-0.3
Reaction time trials AUC	0.1	0.2	0.4	0.2	0.5	0.6	-0.4
Run reversals in cocaine runway, females	0.2	0.2	0.2	0.5	0.4	0.3	-0.5
Run reversals in cocaine runway, males	0.2	0.2	0.4	-0.1	-0.1	-0.6	-0.5
Latency to leave start box in cocaine runway	0.4	0.5	0.6	0.5	0.8	0.8	-0.7
Latency to leave start box in cocaine runway, F	0.7	0.8	1.0	0.7	1.0	1.0	-0.9
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	0.4	0.4	0.3	-0.6
Std. dev. time between licks in bursts	2.7	3.7	5.3	1.5	2.3	1.7	-2.1
Total sessions with >9 infusions	1.4	1.8	2.2	-1.3	-1.4	-1.5	1.0
Short access day 1 total inactive lever presses	0.1	0.1	0.4	-0.2	-0.0	-0.4	-0.6
Short access day 10 total inactive lever presses	0.7	1.8	2.4	1.3	1.6	1.2	-1.3
Short access day 1 total infusions	0.6	0.8	1.1	-0.8	-1.0	-0.8	1.0
Short access day 10 total infusions	3.0	3.8	4.5	-1.9	-2.0	-1.7	2.1
Short access total infusions	2.9	3.7	4.4	-1.8	-2.0	-1.7	2.1
Short access day 1 locomotion	0.6	0.7	1.2	-1.1	-1.0	-0.6	0.6
Short access day 10 total locomotion	0.2	0.3	0.5	-0.4	-0.7	-0.7	0.5
Short access total locomotion	0.5	0.6	0.9	-0.8	-0.9	-0.6	0.7
One hour access (0.3 mA shock)	0.4	0.4	1.1	-0.3	-0.7	-0.3	1.0
Compulsive drug intake	0.5	0.6	0.9	-0.4	-0.8	-0.9	1.0
One hour access (shock baseline)	0.0	0.0	0.1	-0.1	-0.2	0.1	0.3
Social response proportion	0.8	1.0	2.1	1.4	1.0	0.5	-0.6
Social responses	1.3	1.7	2.7	1.7	1.3	1.1	-1.0
Social time	0.0	0.0	0.1	0.4	0.1	0.0	0.3
Soleus weight	1.1	3.1	5.1	-2.3	-1.7	-2.0	0.6
Bone: stiffness	0.0	0.1	0.2	0.1	-0.1	-0.4	-0.2
Tibialis anterior weight	3.2	10.8	16.7	-4.1	-3.5	-3.2	2.0
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.6	-0.5	-0.6	-0.3	0.8
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.8	-0.9	-0.6	-0.5	0.2
Time to tail flick, test, before self-admin	0.0	0.0	0.1	-0.2	0.2	-0.2	0.3
Time to tail flick, test, after self-admin	0.6	0.6	1.3	0.3	0.6	1.1	-0.8
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.1	0.2	-0.0	-0.4
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	-0.3	-0.3	0.1	-0.3
Tibia length	1.1	3.1	4.0	-2.0	-1.9	-2.0	1.0
Ambulatory time before self-admin	0.2	0.4	0.6	-0.8	-0.7	-0.5	0.3
Ambulatory time after self-admin	1.9	2.3	2.5	-1.6	-1.5	-1.4	1.5
Bone: tissue strength	2.5	2.5	3.4	1.9	1.7	1.3	-1.4
Total heroin consumption	0.2	0.2	0.7	-0.1	-0.2	-0.3	0.9
Bone: trabecular number	0.2	0.4	0.8	-0.5	-0.6	-0.9	0.3
Bone: trabecular spacing	4.1	5.4	7.1	2.7	2.4	2.4	-1.8
Bone: trabecular thickness	0.3	0.4	0.6	-0.6	-0.6	-0.8	0.5
Bone: trabecular tissue density	0.2	0.3	0.8	-0.0	0.5	0.9	-0.5
Water consumed over 24 hours	0.3	0.4	1.0	-1.0	-0.3	-0.1	-0.8
Number of responses in last shaping day	9.8	10.7	13.6	-3.6	-3.7	-3.2	2.5