Hub : Genes

Grm4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Grm4	0.18	0.08	9.0e-09	0.04	0.08	0.06	0.08	1.9e-05	2.7e-09	7.4e-08	3.8e-09
2	PL	gene expression	Grm4	0.05	0.03	7.2e-04	0.04	0.02	0.01	0.03	5.0e-05	5.9e-03	8.8e-03	5.5e-04
3	NAcc	mRNA stability	Grm4	0.04	0.02	1.2e-05	0.03	0.04	0.03	0.03	2.2e-04	5.3e-05	2.0e-04	1.2e-04
4	Brain	mRNA stability	Grm4	0.28	0.1	0.0e+00	0.17	0.18	0.19	0.2	7.2e-16	8.9e-17	2.0e-17	2.7e-18

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.5	0.8	2.0	0.3	-1.4	-0.8	-0.7
Area under the delay curve	0.3	0.3	0.8	0.6	0.9	-0.1	0.1
BMI with tail	1.5	5.0	7.9	-2.8	2.1	2.6	1.1
BMI without tail	1.1	2.3	4.4	-0.5	1.7	1.3	2.1
Body weight	1.6	6.7	13.5	-0.2	3.7	3.6	0.6
Weight adjusted by age	0.9	1.0	2.8	0.3	1.7	1.0	-0.2
Bone surface	0.4	0.8	1.2	0.9	-0.9	-0.4	-1.1
Bone volume	0.2	0.3	0.6	0.6	-0.7	-0.4	-0.5
Breakpoint value in progressive ratio session	0.4	0.4	1.1	-0.3	-1.1	0.5	-0.4
Number of licking bursts	1.0	1.2	2.0	0.9	-1.4	-0.8	-1.2
Context. condit. distance diff. score	6.3	7.6	12.3	2.3	-3.5	-2.0	-2.9
Locomotion velocity, session 1	1.9	2.0	3.3	1.8	-1.1	-1.8	-0.6
Locomotion distance, session 1	0.9	1.2	3.5	-0.3	-1.1	-1.9	-0.2
Locomotion velocity, session 2	0.9	1.1	1.6	1.3	-1.2	-1.0	-0.7
Locomotion distance, session 2	0.7	1.0	1.5	0.0	-1.1	-1.2	-1.2
Locomotion velocity, session 3	0.3	0.4	0.7	0.2	0.2	-0.8	0.9
Locomotion distance, session 3	1.3	1.4	3.2	0.4	-1.4	-1.8	-0.3
Stereotopy head waving bouts, day 3	0.5	0.6	1.1	1.1	0.5	0.5	-0.9
Stereotopy head waving duration, day 3	0.3	0.4	0.9	0.9	0.9	0.0	-0.0
Locomotion velocity, session 7	2.1	2.3	3.2	0.7	-1.8	-1.5	-1.8
Locomotion distance, session 7	2.7	3.4	5.7	1.3	-2.4	-2.3	-0.9
Stereotopy head waving bouts, day 7	0.8	0.9	2.7	0.7	0.5	-0.5	1.7
Stereotopy head waving duration, day 7	0.6	0.7	1.7	0.3	1.0	0.3	1.3
Locomotion velocity, session 8	4.0	4.7	8.4	2.9	-2.0	-1.3	-2.2
Locomotion distance, session 8	4.8	7.0	11.2	1.4	-3.4	-2.2	-3.1
Degree of sensitization distance	0.4	0.4	0.6	0.7	-0.5	0.4	-0.8
Degree of sensitization stereotypy	1.0	1.1	3.1	0.5	-0.1	-0.9	1.8
Conditioned locomotion	0.7	0.8	2.1	-0.2	-0.2	1.5	-1.0
Cocaine response after cond. corrected	1.0	1.1	2.0	-1.4	-0.4	0.8	-1.3
Cocaine response after cond. not corrected	0.3	0.4	0.8	-0.5	0.1	0.7	-0.9
Cocaine response before conditioning	1.0	1.2	2.6	1.6	1.2	-0.1	0.7
Saline control response	4.7	6.1	8.3	-2.0	2.7	2.3	2.9
Bone: connectivity density	0.9	1.4	3.0	0.3	-1.5	-0.5	-1.7
Bone: cortical apparent density	1.7	2.2	3.2	-1.7	1.8	1.2	1.1
Bone: cortical area	0.0	0.0	0.0	-0.2	0.2	0.0	0.2
Bone: cortical porosity	1.7	1.9	3.9	1.2	0.2	-1.5	2.0
Bone: cortical porosity	1.5	1.6	3.3	1.8	-0.1	-1.3	1.1
Bone: cortical thickness	1.6	2.6	5.4	-2.3	1.3	0.1	1.8
Bone: cortical thickness	3.1	3.6	7.2	-2.7	1.6	1.3	1.8
Bone: cortical tissue density	1.5	2.0	3.2	-1.5	1.8	1.2	1.1
Condit. Reinf. active minus inactive responses	0.4	0.5	0.8	0.9	-0.3	-0.6	0.7
Condit. Reinf. active-inactive response ratio	0.9	1.0	1.9	-0.4	1.1	0.8	1.4
Condit. Reinf. active responses	0.1	0.1	0.2	0.4	-0.2	-0.2	0.3
Condit. Reinf. inactive responses	0.1	0.2	0.4	-0.1	-0.6	-0.3	-0.4
Incentive salience index mean	1.5	1.8	3.0	1.5	-1.7	-1.1	-0.9
Condit. Reinf. lever presses	3.2	4.2	8.0	1.5	-2.8	-1.3	-2.2
Condit. Reinf. active minus inactive responses	0.3	0.4	0.5	0.7	0.6	-0.6	0.6
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.6	0.5	-0.2	0.2
Condit. Reinf. active responses	0.2	0.3	0.5	0.7	0.3	-0.7	0.6
Condit. Reinf. inactive responses	0.1	0.1	0.4	-0.1	0.4	0.0	0.6
Condit. Reinf. lever presses	0.8	1.1	2.0	0.9	-0.5	-1.4	1.1
Condit. Reinf. lever reinforcers received	0.4	0.6	1.0	0.8	0.1	-1.0	0.7
Conditioned reinforcement - actives	0.3	0.3	0.8	0.5	0.4	-0.2	-0.9
Conditioned reinforcement - inactives	0.6	0.6	1.3	-0.2	1.0	-0.2	1.2
Conditioned locomotion	0.6	0.8	1.5	1.2	0.0	-0.4	-1.2
Patch foraging indifference point 0 sec	3.1	5.0	8.4	-1.9	2.9	1.7	2.3
Patch foraging indifference point AUC	0.7	0.8	2.6	1.6	0.4	-0.4	0.4
Delay disc. indifference point, 0s delay	0.3	0.4	1.2	0.5	-0.2	-0.2	-1.1
Delay disc. indifference point, 16s delay	0.4	0.4	0.7	-0.4	0.8	-0.4	0.7
Delay disc. indifference point, 2s delay	0.5	0.6	1.5	1.2	0.7	-0.1	-0.7
Delay disc. indifference point, 24s delay	1.2	1.2	2.9	-0.2	1.7	0.2	1.3
Delay disc. indifference point, 4s delay	0.7	0.8	1.7	1.0	1.3	0.7	-0.1
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	0.6	0.6	0.0	0.3
Indifference point function ln k	0.4	0.6	1.1	0.2	-1.0	-0.9	-0.5
Indifference point function log k	0.4	0.6	1.1	0.2	-1.0	-0.9	-0.5
Patch foraging total patch changes 0 sec	3.5	5.6	8.9	-2.1	3.0	1.7	2.5
Patch foraging total patch changes 12 sec	1.8	2.4	4.2	-1.4	2.1	0.8	1.6
Patch foraging total patch changes 18 sec	3.3	4.3	5.0	-2.2	2.2	1.7	2.1
Patch foraging total patch changes 24 sec	1.7	2.1	3.9	-1.8	1.1	0.4	2.0
Patch foraging total patch changes 6 sec	2.9	4.2	6.7	-2.0	2.6	1.1	2.3
Patch foraging time to switch 0 sec	2.3	3.5	9.7	-3.1	0.6	2.0	0.2
Patch foraging water rate 0 sec	0.2	0.3	0.8	0.3	0.9	-0.2	-0.3
Patch foraging water rate 12 sec	0.2	0.4	0.7	-0.4	-0.0	-0.9	0.7
Patch foraging water rate 18 sec	0.2	0.2	0.6	0.1	0.8	0.4	0.3
Patch foraging water rate 24 sec	0.1	0.1	0.3	-0.1	0.6	-0.3	0.1
Patch foraging water rate 6 sec	0.1	0.1	0.4	-0.3	0.3	-0.6	0.2
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.8	-0.0	0.9	0.6	1.3
Distance traveled before self-admin	0.6	0.7	1.7	-0.4	-0.5	0.8	-1.3
Distance traveled after self-admin	0.5	0.6	1.7	-0.3	0.7	1.3	0.0
Extensor digitorum longus weight	0.5	2.1	3.7	1.9	-1.0	-0.7	-1.8
Bone: elastic displacement	0.7	0.8	1.7	0.1	0.7	-1.0	1.3
Bone: elastic work	0.3	0.3	0.6	-0.4	0.8	-0.1	0.8
Bone: endosteal estimation	1.2	2.5	4.3	2.1	0.4	2.0	-1.4
Bone: endosteal perimeter	1.0	2.1	3.4	1.7	-1.1	0.9	-1.8
Epididymis fat weight	6.8	16.0	32.9	-5.7	3.5	2.3	3.7
Delta time in closed arm before/after self-admin	0.6	0.6	1.7	-1.3	0.5	0.6	0.1
Delta time in open arm before/after self-admin	0.3	0.3	1.0	1.0	0.3	-0.0	-0.0
Diff in mean of infusions in LGA sessions	1.1	1.2	3.1	-0.5	-1.8	-0.5	-1.2
Delay discount exponential model param	0.3	0.4	0.8	-0.7	-0.9	0.2	-0.2
Extinction: sum of active levers before priming	0.3	0.3	0.6	-0.7	-0.8	-0.2	-0.4
Active lever presses in extinction session 6	0.4	0.4	0.5	-0.7	0.6	0.6	0.4
Bone: final force	3.2	5.1	7.9	-2.3	2.5	2.8	1.1
Bone: final moment	2.2	3.5	5.6	-1.6	2.2	2.4	0.9
Food consumed during 24 hour testing period	0.8	1.0	2.9	-0.8	0.2	1.7	-0.7
Glucose	5.0	7.5	12.3	2.9	-2.4	-1.9	-3.5
Heart weight	0.5	0.8	2.2	0.7	0.6	-1.5	0.2
Delay discount hyperbolic model param	0.4	0.4	0.9	-0.9	-0.9	0.2	-0.2
Intermittent access intake day 1-15 change	0.5	0.5	1.3	0.4	0.3	0.6	1.2
Intermittent access intake escalation	0.3	0.3	0.5	0.7	-0.2	0.7	0.2
Intermittent access intake escalation 2	3.0	2.9	6.9	2.6	-1.6	-0.6	-1.4
Intermitt. access day 1 inactive lever presses	0.6	0.7	2.2	-1.5	-0.5	-0.0	-0.4
Intermitt. access day 15 inactive lever presses	1.1	1.2	1.7	-0.6	1.3	1.1	1.3
Intermitt. access escalation Index	1.3	1.2	2.8	-0.7	-1.7	-0.4	-1.1
Intermittent access day 1 total infusions	0.5	0.6	1.3	0.9	-0.3	-1.1	-0.4
Intermittent access day 15 total infusions	0.0	0.0	0.1	0.4	-0.0	-0.1	-0.1
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.3	0.6	0.3	-0.3	0.1
Intermittent access total infusions	0.2	0.2	0.5	0.7	0.4	-0.4	-0.0
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.4	0.3	-0.2	-0.4
Intermittent access day 15 total locomotion	0.8	0.8	1.2	1.0	1.0	1.1	-0.3
Intermittent access total locomotion	0.8	0.9	2.0	1.4	0.8	0.8	-0.6
Intermittent access standard deviation	2.9	3.0	3.8	-1.3	2.0	1.8	1.8
Left kidney weight	0.5	1.4	2.7	0.4	1.6	1.5	0.8
Right kidney weight	0.5	1.5	2.8	1.0	1.4	1.7	0.2
Cocaine induced anxiety	1.0	1.2	2.3	0.5	-1.5	0.0	-1.5
Post-drug Anxiety	0.6	0.6	1.7	-0.0	-0.8	0.4	-1.3
Baseline Anxiety	1.1	1.1	2.1	-1.5	1.0	0.4	1.1
Tail length	1.5	4.7	18.2	4.3	0.7	-0.1	-0.2
Length with tail	1.1	3.9	11.9	3.4	1.6	0.8	-0.7
Length without tail	0.7	1.5	2.5	0.7	1.6	1.5	-1.0
Times rat made contact with spout	0.8	0.9	3.0	-0.3	0.4	-0.6	1.7
Lifetime Intake	0.1	0.1	0.2	0.5	0.4	-0.3	-0.1
Liver weight, left	1.1	1.7	3.6	1.9	0.8	1.5	-0.7
Liver weight, right	2.4	4.0	13.9	3.7	-0.5	-0.3	-1.4
Locomotor activity	0.3	0.4	0.9	0.3	0.7	0.5	0.9
Locomotor testing distance	0.4	0.7	1.5	-1.2	0.6	0.6	0.7
Locomotor testing rearing	0.6	0.9	2.1	-0.8	0.7	1.5	-0.4
Locomotion in novel chamber	0.1	0.2	0.3	0.6	0.1	-0.5	-0.3
Locomotion in novel chamber post-restriction	0.9	1.1	1.6	-1.2	1.1	1.3	0.3
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	0.4	-0.2	0.2	-0.5
Change in fecal boli incidents, locomotor task	0.2	0.2	0.7	-0.9	0.1	0.2	-0.3
Time >=10cm from walls, locomotor time 1	2.2	2.3	6.1	-1.1	0.5	2.5	-1.3
Bouts of movement, locomotor time 1	0.7	0.8	1.4	1.2	-1.2	-0.4	-0.4
Total resting periods, locomotor time 1	0.8	0.9	1.8	1.3	-1.1	-0.3	-0.7
Rest time, locomotor task time 1	1.9	2.1	5.3	2.3	-0.9	-1.0	-1.1
Distance moved, locomotor task time 1	2.1	2.3	3.2	-1.8	1.6	1.5	1.0
Vertical activity count, locomotor time 1	4.4	4.6	7.4	-2.1	2.3	2.7	1.3
Time >=10cm from walls, locomotor time 2	2.3	2.4	5.8	-1.3	1.3	2.4	-0.6
Bouts of movement, locomotor time 2	0.9	1.0	4.0	2.0	0.1	0.2	0.2
Total resting periods, locomotor time 2	1.5	1.6	5.9	2.4	-0.5	-0.3	-0.1
Rest time, locomotor task time 2	2.5	2.9	4.8	1.7	-1.9	-0.5	-2.2
Distance moved, locomotor task time 2	2.6	3.0	4.1	-2.0	2.0	1.7	1.2
Vertical activity count, locomotor time 2	2.2	2.4	3.8	-1.4	1.9	1.8	0.7
Light reinforcement 1	1.9	3.5	7.0	-2.7	1.1	2.3	-0.1
Light reinforcement 2	1.0	1.3	3.5	-0.7	0.8	1.9	-0.9
Bone: marrow area	1.2	2.6	4.3	2.0	0.5	2.1	-1.3
Bone: maximum diameter	1.6	2.9	4.8	2.2	-1.6	-0.6	-2.0
Bone: maximum force	1.0	1.6	3.0	-0.9	1.7	1.5	0.6
Bone: maximum moment	0.5	0.9	2.1	-0.3	1.5	1.1	0.4
Mean time between licks in bursts	4.0	5.7	8.3	2.9	-2.4	-2.0	-2.2
Mean num. licks in bursts	1.6	1.9	3.9	-1.0	1.6	0.4	2.0
Cd content in liver	1.0	1.1	2.0	-1.4	0.8	1.3	-0.5
Co content in liver	3.6	4.2	7.2	-2.7	1.9	2.2	1.1
Cu content in liver	0.7	0.8	1.5	-1.2	-0.4	-1.1	0.7
Fe content in liver	0.3	0.4	1.3	0.3	1.1	0.5	0.2
K content in liver	2.6	2.6	3.5	1.5	-1.9	-1.8	-1.2
Mg content in liver	7.3	7.5	10.0	2.8	-3.2	-2.8	-2.1
Mn content in liver	4.1	4.6	7.0	2.7	-2.0	-1.2	-2.4
Na content in liver	0.1	0.2	0.3	0.2	-0.5	-0.6	-0.0
Rb content in liver	0.9	1.1	3.2	0.5	-0.9	0.1	-1.8
Se content in liver	6.3	7.7	12.7	3.6	-2.4	-3.2	-1.6
Sr content in liver	0.3	0.2	0.7	-0.4	0.0	0.4	-0.8
Zn content in liver	0.7	0.8	2.6	0.4	-0.4	-0.5	-1.6
Bone: minimum diameter	0.5	1.0	1.7	1.1	-0.5	0.8	-1.3
Time in familiar zone, hab. session 1	0.4	0.4	0.7	0.3	-0.4	-0.8	0.8
Time in novel zone, hab. session 1	0.4	0.4	0.6	-0.4	0.7	0.6	-0.7
Total zone transitions, hab. session 1	0.8	1.1	2.6	-0.8	-1.0	-1.6	-0.0
Total locomotion distance, hab. session 1	1.1	1.5	3.6	-0.4	-1.5	-1.9	-0.5
Locomotion velocity, hab. session 1	0.9	1.2	3.4	-0.3	-1.2	-1.8	-0.2
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.1	0.2	0.1	0.4
Time in novel zone, hab. session 2	0.2	0.2	0.5	0.3	0.7	0.5	-0.3
Total zone transitions, hab. session 2	0.4	0.5	1.1	-1.0	-0.7	-0.6	-0.5
Total locomotion distance, hab. session 2	1.2	1.6	2.9	-0.9	-1.7	-1.4	-1.0
Locomotion velocity, hab. session 2	1.7	2.2	4.2	-0.6	-2.1	-1.8	-1.1
Novel to familiar place preference ratio	0.2	0.2	0.4	-0.5	-0.1	-0.2	0.6
Novelty place preference	0.1	0.1	0.3	-0.2	0.0	-0.3	0.6
Time in novel zone, NPP test	0.1	0.1	0.2	0.0	0.2	-0.2	0.5
Total zone transitions, NPP test	1.3	1.9	3.5	-0.0	-1.7	-1.9	-1.0
Total locomotion distance, NPP test	1.1	1.5	2.4	-0.7	-1.5	-1.2	-1.3
Locomotion velocity, NPP test	1.4	2.0	3.8	-1.1	-2.0	-1.4	-1.0
Intraocular pressure	0.2	0.2	0.5	0.5	-0.2	0.3	-0.7
Delta distance traveled before/after self-admin	1.1	1.2	2.4	0.6	1.3	0.5	1.5
Delta ambulatory time before/after self-admin	0.5	0.6	0.9	0.7	0.8	0.5	1.0
Parametrial fat weight	0.8	1.7	3.5	-1.1	1.2	1.9	0.7
Pavlov. Cond. lever latency	5.8	7.3	10.1	-2.8	3.2	3.0	1.5
Pavlov. Cond. magazine entry latency	3.8	4.9	10.3	3.2	-1.9	-2.3	-0.6
Pavlov. Cond. change in total contacts	1.2	1.3	3.1	1.8	-0.9	-1.1	0.0
Pavlov. Cond. index score	5.4	6.8	10.2	3.2	-2.8	-2.8	-1.1
Pavlov. Cond. latency score	5.3	6.8	10.0	3.2	-2.9	-2.8	-1.1
Pavlov. Cond. lever contacts	4.5	5.2	7.1	2.2	-2.7	-2.6	-1.5
Pavlov. Cond. magazine entry number	2.7	3.4	5.8	-2.4	1.7	2.1	0.4
Pavlov. Cond. intertrial magazine entries	1.4	1.7	3.9	-2.0	1.2	0.9	0.7
Pavlov. Cond. lever-magazine prob. diff.	5.3	6.6	9.7	3.1	-2.7	-2.8	-1.1
Pavlov. Cond. response bias	4.8	5.9	9.3	3.0	-2.3	-2.7	-1.3
Pavlov. Cond. lever latency	0.8	1.0	2.1	-0.9	0.2	1.5	-1.0
Pavlov. Cond. magazine entry latency	0.7	0.8	2.6	1.6	-0.7	-0.0	-0.5
Pavlov. Cond. change in total contacts	0.6	0.9	2.2	0.8	-0.0	-0.9	1.5
Pavlov. Cond. index score	0.6	0.8	2.0	1.4	-0.4	-0.9	0.6
Pavlov. Cond. latency score	0.5	0.6	1.7	1.3	-0.3	-0.7	0.5
Pavlov. Cond. lever contacts	0.7	0.9	2.7	0.2	0.3	-0.9	1.6
Pavlov. Cond. magazine entry number	0.1	0.2	0.5	-0.7	0.3	-0.2	-0.0
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.7	1.3	-1.2	-0.7	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.7	1.3	-0.3	-0.7	0.7
Pavlov. Cond. response bias	0.7	1.0	1.4	1.2	-0.3	-1.2	1.1
Time in closed arm before self-admin	0.1	0.1	0.2	0.5	-0.1	-0.1	-0.5
Time in closed arm after self-admin	0.1	0.1	0.2	-0.5	0.3	-0.2	0.3
Time in open arm before self-admin	0.9	1.0	1.9	1.4	-0.7	-1.1	0.7
Time in open arm after self-admin	1.2	1.3	4.1	2.0	-0.4	-0.9	-0.0
Bone: periosteal estimation	0.4	0.9	1.9	1.0	0.5	1.4	-0.7
Bone: periosteal perimeter	0.2	0.3	0.6	0.7	-0.1	0.7	-0.4
Bone: post-yield work	0.7	0.9	2.0	1.2	-0.4	0.4	-1.4
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	0.3	0.1	-0.6	-0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	-0.0	0.2	-0.5	-0.0
Progressive ratio test 1 inactive lever presses	0.9	1.0	2.4	-1.6	0.8	0.8	0.7
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	0.2	-0.2	-0.2	-0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	0.2	-0.3	-0.4	0.0
Progressive ratio test 2 inactive lever presses	0.4	0.5	1.5	1.2	-0.1	-0.6	-0.3
Incentive Sensitization - Responses	0.2	0.2	0.6	0.2	-0.8	-0.3	-0.0
Incentive Sensitization - Breakpoint	0.2	0.2	0.7	0.2	-0.9	-0.2	-0.1
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	0.2	-0.4	-0.7	-0.1
Progressive ratio	4.1	4.8	7.0	-1.6	2.6	2.6	1.7
Food seeking constrained by brief footshock	0.5	0.6	2.0	-0.1	0.5	0.3	1.4
Seeking ratio, punishment vs. effort	1.8	2.2	4.3	0.8	-1.9	-2.1	-0.5
Retroperitoneal fat weight	0.2	0.7	1.1	-0.8	1.0	0.9	0.5
Reaction time number correct	1.7	2.4	3.6	-1.9	1.4	1.3	1.5
Reaction time mean minus median	4.0	5.3	13.5	3.7	-1.8	-0.7	-1.9
Reaction time mean minus median AUC	4.0	5.2	12.7	3.6	-1.7	-0.8	-2.1
Reaction time num false alarms	0.2	0.3	0.5	0.7	-0.6	-0.4	-0.0
Reaction time num false alarms AUC	0.2	0.3	0.4	0.7	-0.5	-0.6	0.2
Reaction time trials correct on left	1.7	2.4	3.6	-1.9	1.4	1.3	1.5
Reaction time trials on left	1.6	2.3	3.3	-1.8	1.4	1.3	1.5
Reaction time mean	2.6	3.6	5.9	2.4	-1.7	-0.0	-2.4
Reaction time mean AUC	2.5	3.4	6.4	2.5	-1.6	0.1	-2.2
Median of all reaction times	1.4	1.9	4.1	1.3	-1.3	0.3	-2.0
Reaction time omissions	1.6	2.2	3.7	1.9	-1.6	-0.1	-1.6
Reaction time false alarm rate	1.3	1.8	2.9	1.7	-1.2	-1.5	-0.6
Reaction time premature initiation rate	0.1	0.2	0.4	-0.7	0.3	0.4	0.0
Reaction time premature initiations	1.2	1.8	3.0	-1.7	1.3	1.3	0.9
Std. dev. reaction times	3.6	5.1	13.6	3.7	-1.7	-0.6	-1.9
Reaction time trials completed	1.6	2.3	3.3	-1.8	1.4	1.3	1.5
Reaction time trials AUC	1.6	2.4	3.7	-1.9	1.4	1.4	1.4
Run reversals in cocaine runway, females	0.6	0.6	1.0	-0.7	0.9	0.1	1.0
Run reversals in cocaine runway, males	2.7	2.6	6.1	2.5	-1.4	-0.9	-1.2
Latency to leave start box in cocaine runway	0.5	0.6	1.2	-0.8	-1.1	-0.5	-0.4
Latency to leave start box in cocaine runway, F	0.4	0.4	1.0	-0.5	-1.0	-0.4	-0.6
Latency to leave start box in cocaine runway, M	0.4	0.3	1.1	-1.0	-0.3	-0.3	0.4
Std. dev. time between licks in bursts	4.0	4.8	5.3	2.2	-2.3	-1.9	-2.2
Total sessions with >9 infusions	0.2	0.2	0.3	0.6	-0.2	-0.5	-0.6
Short access day 1 total inactive lever presses	1.4	1.5	1.8	1.3	-1.3	-1.0	-1.3
Short access day 10 total inactive lever presses	0.5	0.5	1.0	-1.0	-0.9	0.4	0.3
Short access day 1 total infusions	0.7	0.8	1.9	0.9	-0.5	-1.4	-0.3
Short access day 10 total infusions	0.1	0.1	0.2	-0.2	0.5	0.2	0.1
Short access total infusions	0.1	0.1	0.3	0.3	0.3	-0.5	0.1
Short access day 1 locomotion	0.7	0.7	1.7	-0.5	-1.3	-0.8	-0.4
Short access day 10 total locomotion	0.2	0.2	0.9	0.3	-0.1	-0.1	-0.9
Short access total locomotion	0.1	0.1	0.2	-0.4	0.1	0.2	-0.5
One hour access (0.3 mA shock)	1.2	1.4	2.2	0.8	-1.5	-1.1	-1.3
Compulsive drug intake	1.7	1.7	4.2	-0.3	-2.1	-0.8	-1.3
One hour access (shock baseline)	0.8	1.0	3.4	1.8	0.5	-0.2	-0.4
Social response proportion	0.1	0.1	0.3	-0.1	0.6	0.3	-0.4
Social responses	0.1	0.1	0.2	-0.3	0.4	0.3	0.2
Social time	2.1	2.7	4.5	1.6	-2.1	-0.5	-1.9
Soleus weight	2.0	5.9	10.9	3.1	-1.5	-0.8	-3.3
Bone: stiffness	0.9	1.4	2.3	-1.2	1.3	1.5	0.5
Tibialis anterior weight	0.0	0.2	0.3	-0.5	-0.0	-0.4	0.4
Time to tail flick, vehicle, before self-admin	0.5	0.5	0.8	-0.3	-0.8	0.6	-0.9
Time to tail flick, vehicle, after self-admin	0.4	0.4	0.7	0.4	-0.7	0.4	-0.8
Time to tail flick, test, before self-admin	0.3	0.3	0.7	-0.5	0.2	-0.2	0.8
Time to tail flick, test, after self-admin	2.1	2.2	4.2	2.0	-1.6	-1.3	-0.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	0.5	-0.2	-0.6	0.3
Delta time to tail flick, test, before/after SA	0.3	0.3	0.9	0.2	-1.0	-0.1	-0.3
Tibia length	0.6	1.7	3.4	1.3	0.4	1.9	-1.2
Ambulatory time before self-admin	0.3	0.3	0.5	-0.4	-0.7	0.3	-0.7
Ambulatory time after self-admin	0.2	0.2	0.6	0.1	0.3	0.8	0.1
Bone: tissue strength	0.3	0.3	0.6	-0.3	0.8	0.7	-0.3
Total heroin consumption	0.0	0.0	0.1	0.1	-0.3	0.1	0.1
Bone: trabecular number	0.6	0.9	2.1	0.1	-1.5	-1.0	-0.6
Bone: trabecular spacing	1.3	1.8	3.3	-0.4	1.8	1.6	1.0
Bone: trabecular thickness	0.7	0.8	1.8	0.9	-1.3	-0.3	-0.8
Bone: trabecular tissue density	0.7	1.0	2.6	1.6	0.2	-0.7	1.0
Water consumed over 24 hours	0.2	0.3	0.7	0.1	-0.5	-0.1	-0.8
Number of responses in last shaping day	1.4	1.5	4.4	1.0	-0.5	-2.1	-0.3