Hub : Genes

Grm4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Grm4 0.16 0.07 6.0e-09 0.01 0.05 0.05 0.03 2.8e-03 1.3e-08 1.2e-08 8.5e-06
2 PL gene expression Grm4 0.05 0.03 6.3e-04 0.02 0.03 0.02 0.03 3.4e-03 7.8e-04 1.3e-03 7.1e-04
3 Brain isoform ratio NM_022666.2 0.03 0.02 8.3e-03 0 0 -0 -0 1.3e-01 2.3e-01 3.8e-01 3.7e-01
4 Brain isoform ratio XM_063278955.1 0.03 0.02 7.9e-03 0 0 0 0 9.7e-02 1.6e-01 1.1e-01 3.5e-01
5 Brain alternative TSS XM_063278955.1 0.03 0.02 9.2e-03 0.04 0.02 0.02 0.02 3.2e-04 4.0e-03 6.3e-03 2.7e-03
6 Brain alternative TSS NM_022666.2 0.04 0.03 6.0e-03 0.04 0.02 0.02 0.03 2.0e-04 3.3e-03 5.6e-03 1.7e-03
7 Brain alternative TSS XM_063278955.1 0.04 0.03 5.2e-03 0.04 0.02 0.02 0.03 1.8e-04 2.8e-03 4.5e-03 1.6e-03
8 Brain alternative TSS NM_022666.2 0.03 0.03 8.4e-03 0.04 0.02 0.02 0.02 2.9e-04 3.6e-03 6.9e-03 3.0e-03
9 Brain mRNA stability Grm4 0.27 0.1 0.0e+00 0.18 0.21 0.22 0.22 1.2e-16 2.4e-19 2.9e-20 2.1e-20
10 IC gene expression Grm4 0.17 0.08 6.3e-05 0.07 0.07 0.07 0.08 6.2e-04 5.6e-04 8.8e-04 3.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.10.31.2-0.81.1-0.40.4-0.00.0-0.00.0-0.7-0.1
Area under the delay curve0.10.20.9-0.4-1.00.3-0.3-0.30.3-0.30.3-0.10.1
BMI with tail1.86.214.33.8-1.7-3.23.12.4-2.42.4-2.41.2-0.6
BMI without tail0.73.76.72.1-2.6-2.02.01.6-1.61.6-1.62.4-1.4
Body weight1.56.511.20.8-2.6-2.52.53.4-3.43.4-3.40.30.6
Weight adjusted by age0.20.42.10.5-1.00.2-0.30.4-0.40.4-0.4-0.51.5
Bone surface0.20.41.3-1.11.10.2-0.20.1-0.10.1-0.1-1.10.6
Bone volume0.10.20.7-0.80.6-0.20.20.2-0.20.2-0.2-0.60.1
Breakpoint value in progressive ratio session0.71.22.80.40.6-0.20.31.7-1.71.7-1.7-0.0-0.3
Number of licking bursts0.30.92.2-0.61.50.9-0.9-0.80.8-0.80.8-1.10.9
Context. condit. distance diff. score3.64.313.5-1.53.71.9-1.9-1.21.2-1.21.2-3.02.2
Locomotion velocity, session 12.32.65.6-2.40.81.8-1.9-1.81.8-1.81.8-0.40.2
Locomotion distance, session 11.51.93.6-0.60.81.3-1.3-1.91.9-1.91.9-0.1-0.3
Locomotion velocity, session 20.70.92.3-1.51.01.0-1.0-0.90.9-0.90.9-0.60.2
Locomotion distance, session 20.70.91.4-0.21.20.9-0.8-1.11.1-1.11.1-0.90.8
Locomotion velocity, session 31.01.11.9-0.7-0.60.9-1.0-1.21.2-1.21.20.9-1.4
Locomotion distance, session 31.61.82.9-0.81.01.5-1.5-1.71.7-1.71.7-0.1-0.5
Stereotopy head waving bouts, day 30.20.30.9-0.6-0.00.5-0.50.3-0.30.3-0.3-0.80.9
Stereotopy head waving duration, day 30.20.30.6-0.8-0.60.7-0.7-0.40.4-0.40.40.10.3
Locomotion velocity, session 71.31.53.3-0.61.81.0-1.0-1.11.1-1.11.1-1.81.0
Locomotion distance, session 71.72.24.1-0.92.01.7-1.7-1.61.6-1.61.6-0.90.5
Stereotopy head waving bouts, day 71.21.43.4-1.8-1.20.6-0.6-0.70.7-0.70.71.8-1.9
Stereotopy head waving duration, day 70.50.61.9-1.1-1.30.1-0.1-0.20.2-0.20.21.3-1.4
Locomotion velocity, session 82.63.15.5-2.32.22.1-2.2-0.90.9-0.90.9-2.21.8
Locomotion distance, session 83.44.913.4-1.03.72.1-2.0-1.71.7-1.71.7-3.12.3
Degree of sensitization distance0.60.71.60.20.8-0.40.40.9-0.90.9-0.9-1.01.3
Degree of sensitization stereotypy1.31.54.2-1.5-0.70.7-0.7-1.01.0-1.01.01.7-2.0
Conditioned locomotion1.82.23.60.90.6-1.41.51.9-1.91.9-1.9-1.01.0
Cocaine response after cond. corrected0.91.32.91.70.9-1.31.30.7-0.70.7-0.7-1.41.4
Cocaine response after cond. not corrected0.30.51.20.90.4-0.70.70.3-0.30.3-0.3-1.11.1
Cocaine response before conditioning0.81.02.6-1.6-1.41.2-1.2-0.70.7-0.70.70.7-0.7
Saline control response3.44.710.90.5-3.3-2.52.51.7-1.71.7-1.72.7-2.2
Bone: connectivity density0.40.72.7-0.41.5-0.50.50.2-0.20.2-0.2-1.60.9
Bone: cortical apparent density0.81.33.01.1-1.7-1.51.50.7-0.70.7-0.70.8-1.2
Bone: cortical area0.00.00.2-0.1-0.1-0.00.1-0.20.2-0.20.20.4-0.3
Bone: cortical porosity2.32.54.8-1.6-0.81.7-1.6-1.51.5-1.51.52.2-1.6
Bone: cortical porosity2.02.23.8-2.0-0.41.7-1.7-1.51.5-1.51.51.3-0.8
Bone: cortical thickness0.91.65.11.2-1.6-0.90.9-0.50.5-0.50.52.0-2.3
Bone: cortical thickness2.32.84.91.8-1.9-2.22.21.0-1.01.0-1.01.8-2.0
Bone: cortical tissue density0.71.12.70.9-1.6-1.41.40.7-0.70.7-0.70.7-1.1
Condit. Reinf. active minus inactive responses0.30.41.3-1.1-0.10.5-0.5-0.60.6-0.60.60.7-0.4
Condit. Reinf. active-inactive response ratio0.70.71.60.0-1.2-0.91.00.7-0.70.7-0.71.3-0.8
Condit. Reinf. active responses0.00.00.2-0.40.0-0.20.20.0-0.00.0-0.00.2-0.0
Condit. Reinf. inactive responses0.10.10.30.20.5-0.30.3-0.00.0-0.00.0-0.50.1
Incentive salience index mean0.71.02.6-1.21.60.9-0.9-0.70.7-0.70.7-0.81.0
Condit. Reinf. lever presses1.82.610.7-0.83.31.1-1.0-0.50.5-0.50.5-2.62.3
Condit. Reinf. active minus inactive responses0.30.51.4-0.4-0.71.2-1.2-0.60.6-0.60.60.7-0.1
Condit. Reinf. active-inactive response ratio0.20.30.8-0.0-0.40.9-0.9-0.40.4-0.40.40.30.4
Condit. Reinf. active responses0.30.41.1-0.6-0.51.0-1.1-0.50.5-0.50.50.5-0.4
Condit. Reinf. inactive responses0.10.20.9-0.5-0.6-0.10.10.2-0.20.2-0.20.5-1.0
Condit. Reinf. lever presses0.91.32.1-1.40.21.3-1.3-1.21.2-1.21.21.1-0.7
Condit. Reinf. lever reinforcers received0.60.81.6-0.9-0.41.3-1.3-0.90.9-0.90.90.7-0.5
Conditioned reinforcement - actives0.10.20.9-0.9-0.40.1-0.0-0.30.3-0.30.3-0.90.2
Conditioned reinforcement - inactives0.30.71.30.4-0.60.6-0.5-1.21.2-1.21.20.9-0.1
Conditioned locomotion0.30.41.3-1.1-0.10.4-0.3-0.40.4-0.40.4-1.01.1
Patch foraging indifference point 0 sec1.13.09.61.4-3.1-2.02.01.0-1.01.0-1.01.9-1.6
Patch foraging indifference point AUC0.41.14.5-2.1-0.20.7-0.6-1.11.1-1.11.10.1-0.6
Delay disc. indifference point, 0s delay0.30.41.2-0.70.30.6-0.6-0.40.4-0.40.4-1.11.0
Delay disc. indifference point, 16s delay0.30.51.20.5-1.10.3-0.3-0.70.7-0.70.70.9-0.5
Delay disc. indifference point, 2s delay0.40.50.6-0.7-0.60.8-0.8-0.70.7-0.70.7-0.70.7
Delay disc. indifference point, 24s delay0.40.63.30.9-1.80.3-0.3-0.30.3-0.30.31.3-0.2
Delay disc. indifference point, 4s delay0.50.52.2-1.5-1.30.10.00.4-0.40.4-0.4-0.4-0.3
Delay disc. indifference point, 8s delay0.00.10.50.1-0.70.1-0.10.1-0.10.1-0.10.20.3
Indifference point function ln k0.10.41.30.30.91.0-1.1-0.40.4-0.40.4-0.40.3
Indifference point function log k0.10.41.30.30.91.0-1.1-0.40.4-0.40.4-0.40.3
Patch foraging total patch changes 0 sec1.13.110.11.5-3.2-2.02.00.9-0.90.9-0.92.2-1.8
Patch foraging total patch changes 12 sec0.81.14.10.6-2.0-0.91.0-0.00.0-0.00.01.6-1.6
Patch foraging total patch changes 18 sec1.22.86.71.1-2.2-2.52.61.0-1.01.0-1.01.5-1.7
Patch foraging total patch changes 24 sec0.31.12.30.6-1.3-1.51.50.1-0.10.1-0.11.5-1.5
Patch foraging total patch changes 6 sec1.32.27.21.3-2.7-1.61.7-0.00.0-0.00.02.0-1.8
Patch foraging time to switch 0 sec1.14.310.73.3-0.1-2.22.22.4-2.42.4-2.40.10.5
Patch foraging water rate 0 sec0.10.41.1-0.1-1.00.0-0.0-0.80.8-0.80.8-0.20.2
Patch foraging water rate 12 sec0.20.81.7-0.3-0.50.10.0-1.11.1-1.11.10.5-1.3
Patch foraging water rate 18 sec0.10.20.90.2-0.9-0.60.60.2-0.20.2-0.20.1-0.1
Patch foraging water rate 24 sec0.30.40.80.1-0.90.3-0.3-0.70.7-0.70.70.1-0.9
Patch foraging water rate 6 sec0.20.40.70.2-0.60.10.1-0.80.8-0.80.80.2-0.7
Seeking ratio, delayed vs. immediate footshock0.71.04.3-1.2-1.3-0.50.50.6-0.60.6-0.60.9-2.1
Distance traveled before self-admin0.30.71.40.40.9-0.40.50.9-0.90.9-0.9-1.20.6
Distance traveled after self-admin0.61.02.0-0.2-0.5-0.80.91.4-1.41.4-1.4-0.3-0.4
Extensor digitorum longus weight0.41.53.6-1.91.31.2-1.2-0.70.7-0.70.7-1.61.5
Bone: elastic displacement1.31.62.6-0.7-1.20.8-0.8-1.51.5-1.51.51.6-1.2
Bone: elastic work0.30.41.0-0.1-1.00.0-0.0-0.60.6-0.60.61.0-0.7
Bone: endosteal estimation1.12.76.2-0.80.6-0.30.32.0-2.02.0-2.0-1.82.5
Bone: endosteal perimeter0.92.36.1-0.51.80.0-0.01.5-1.51.5-1.5-2.12.5
Epididymis fat weight3.417.145.86.8-4.2-5.55.32.4-2.42.4-2.43.8-3.7
Delta time in closed arm before/after self-admin0.40.42.51.6-0.4-0.30.30.3-0.30.3-0.30.80.2
Delta time in open arm before/after self-admin0.20.31.7-1.3-0.30.1-0.0-0.10.1-0.10.1-0.8-0.2
Diff in mean of infusions in LGA sessions0.50.83.81.21.9-0.10.20.4-0.40.4-0.4-1.11.0
Delay discount exponential model param0.20.21.10.61.0-0.40.40.4-0.40.4-0.40.00.0
Extinction: sum of active levers before priming0.30.41.41.21.20.3-0.30.4-0.40.4-0.4-0.40.8
Active lever presses in extinction session 60.20.21.30.7-0.4-0.30.40.1-0.10.1-0.11.10.1
Bone: final force2.74.46.52.2-2.0-2.52.62.3-2.32.3-2.30.8-0.6
Bone: final moment1.82.93.91.8-1.8-2.02.01.9-1.91.9-1.90.7-0.4
Food consumed during 24 hour testing period1.53.05.11.40.3-1.71.72.3-2.32.3-2.3-0.61.3
Glucose2.74.211.0-1.02.52.4-2.4-1.31.3-1.31.3-2.43.3
Heart weight1.21.93.20.2-1.41.1-1.2-1.81.8-1.81.81.30.2
Delay discount hyperbolic model param0.30.41.10.81.0-0.60.50.6-0.60.6-0.6-0.10.1
Intermittent access intake day 1-15 change0.20.91.80.2-0.3-0.60.51.3-1.31.3-1.30.4-0.8
Intermittent access intake escalation0.31.42.5-0.2-1.2-0.90.81.4-1.41.4-1.41.1-1.6
Intermittent access intake escalation 20.20.32.2-1.5-0.00.3-0.40.5-0.50.5-0.5-0.2-0.2
Intermitt. access day 1 inactive lever presses0.10.72.31.31.50.4-0.4-0.70.7-0.70.7-0.40.5
Intermitt. access day 15 inactive lever presses0.00.30.40.3-0.4-0.50.50.6-0.60.6-0.60.20.0
Intermitt. access escalation Index0.20.74.5-0.32.10.2-0.30.1-0.10.1-0.1-1.40.0
Intermittent access day 1 total infusions0.61.83.0-1.10.21.4-1.3-1.71.7-1.71.7-0.51.0
Intermittent access day 15 total infusions0.10.30.9-0.9-0.80.2-0.1-0.40.4-0.40.40.5-0.6
Intermittent access terminal intake (last 3 days)0.20.40.9-0.6-1.00.5-0.5-0.60.6-0.60.60.7-0.5
Intermittent access total infusions0.60.71.2-1.1-0.60.7-0.7-1.11.1-1.11.10.3-0.1
Intermittent access day 1 locomotion0.20.31.6-1.3-0.20.10.1-0.40.4-0.40.4-1.00.4
Intermittent access day 15 total locomotion0.31.01.8-0.5-1.1-0.60.71.4-1.41.4-1.4-0.30.4
Intermittent access total locomotion0.40.52.8-1.7-1.0-0.30.50.1-0.10.1-0.1-0.60.2
Intermittent access standard deviation0.52.64.61.6-2.1-1.61.71.5-1.51.5-1.51.6-1.2
Left kidney weight0.64.77.00.1-2.6-2.52.22.6-2.62.6-2.61.1-0.9
Right kidney weight0.96.110.70.1-2.4-2.72.53.3-3.33.3-3.30.1-0.1
Cocaine induced anxiety0.20.41.8-0.71.1-0.30.50.0-0.00.0-0.0-1.40.7
Post-drug Anxiety0.30.41.50.30.4-1.11.20.3-0.30.3-0.3-0.50.3
Baseline Anxiety0.61.05.22.3-0.7-0.90.90.7-0.70.7-0.70.7-0.2
Tail length0.31.48.8-3.0-1.31.2-1.10.2-0.20.2-0.2-0.10.5
Length with tail0.52.39.3-3.1-1.40.4-0.41.4-1.41.4-1.4-1.11.7
Length without tail0.73.56.2-0.0-0.9-1.51.32.2-2.22.2-2.2-2.02.5
Times rat made contact with spout1.01.24.5-0.9-1.1-0.20.2-0.60.6-0.60.61.9-2.1
Lifetime Intake0.40.50.8-0.9-0.70.6-0.6-0.80.8-0.80.80.30.1
Liver weight, left1.22.23.8-1.20.9-0.70.71.7-1.71.7-1.7-1.91.8
Liver weight, right1.32.26.8-2.61.21.0-0.90.4-0.40.4-0.4-2.42.4
Locomotor activity0.20.31.4-0.6-0.80.2-0.10.1-0.10.1-0.10.5-1.2
Locomotor testing distance0.20.41.01.0-0.2-0.50.60.7-0.70.7-0.7-0.1-0.6
Locomotor testing rearing0.41.52.41.1-0.4-1.21.11.6-1.61.6-1.6-1.10.2
Locomotion in novel chamber0.00.10.2-0.3-0.20.3-0.4-0.10.1-0.10.1-0.20.1
Locomotion in novel chamber post-restriction0.51.52.40.9-1.2-1.31.31.6-1.61.6-1.60.2-0.2
Fecal boli incidents, locomotor time 10.20.51.00.40.5-0.50.50.8-0.80.8-0.8-0.91.0
Change in fecal boli incidents, locomotor task0.40.42.91.7-0.2-0.40.40.3-0.30.3-0.30.10.5
Time >=10cm from walls, locomotor time 13.34.16.31.80.3-2.22.22.5-2.52.5-2.5-1.21.1
Bouts of movement, locomotor time 10.40.62.9-1.70.90.2-0.20.6-0.60.6-0.6-0.4-0.6
Total resting periods, locomotor time 10.50.62.9-1.70.90.1-0.10.6-0.60.6-0.6-0.6-0.2
Rest time, locomotor task time 11.11.78.7-2.90.71.2-1.2-1.01.0-1.01.0-1.0-0.0
Distance moved, locomotor task time 10.61.65.72.4-1.1-1.11.11.2-1.21.2-1.20.90.1
Vertical activity count, locomotor time 10.74.78.42.9-1.8-2.32.32.4-2.42.4-2.41.2-0.1
Time >=10cm from walls, locomotor time 21.23.47.42.7-0.5-1.61.62.1-2.12.1-2.1-0.41.6
Bouts of movement, locomotor time 20.41.311.1-3.3-0.00.5-0.50.4-0.40.4-0.4-0.0-0.9
Total resting periods, locomotor time 20.41.814.2-3.80.41.1-1.1-0.20.2-0.20.2-0.2-0.8
Rest time, locomotor task time 21.01.75.8-2.12.10.8-0.8-0.20.2-0.20.2-2.41.0
Distance moved, locomotor task time 22.33.09.83.1-1.7-1.81.81.5-1.51.5-1.51.30.5
Vertical activity count, locomotor time 21.02.47.32.7-1.5-1.61.61.4-1.41.4-1.40.80.7
Light reinforcement 10.83.56.32.0-0.3-2.52.52.1-2.12.1-2.1-0.60.2
Light reinforcement 21.12.54.00.6-0.1-1.81.72.0-2.02.0-2.0-1.20.8
Bone: marrow area1.22.96.0-0.70.5-0.40.42.2-2.22.2-2.2-1.72.5
Bone: maximum diameter0.81.63.6-1.71.91.2-1.2-0.50.5-0.50.5-1.71.8
Bone: maximum force0.51.01.51.0-1.2-1.21.21.1-1.11.1-1.10.1-0.0
Bone: maximum moment0.20.40.90.6-1.0-0.60.60.7-0.70.7-0.7-0.00.2
Mean time between licks in bursts0.84.67.2-2.62.62.7-2.7-1.61.6-1.61.6-2.11.6
Mean num. licks in bursts0.51.34.1-0.1-2.0-0.80.80.1-0.10.1-0.12.0-2.0
Cd content in liver1.31.53.31.8-0.1-1.41.41.0-1.01.0-1.0-1.11.4
Co content in liver3.94.66.72.6-1.5-2.52.52.4-2.42.4-2.40.40.1
Cu content in liver0.60.72.50.8-0.60.00.0-0.70.7-0.70.71.4-1.6
Fe content in liver0.30.40.90.5-0.9-0.70.70.6-0.60.6-0.60.3-0.3
K content in liver1.41.42.1-1.31.51.3-1.2-1.31.3-1.31.3-0.70.4
Mg content in liver1.71.96.1-1.62.51.1-1.0-1.01.0-1.01.0-1.51.2
Mn content in liver2.73.18.3-1.32.61.7-1.6-0.80.8-0.80.8-2.92.6
Na content in liver0.50.62.3-0.4-0.30.4-0.4-0.60.6-0.60.61.2-1.5
Rb content in liver0.50.61.4-0.40.9-0.70.80.5-0.50.5-0.5-1.21.2
Se content in liver4.14.88.4-2.51.52.9-2.9-2.32.3-2.32.3-0.70.9
Sr content in liver0.40.31.50.90.2-0.10.10.3-0.30.3-0.3-0.71.2
Zn content in liver0.91.12.6-0.20.81.1-1.1-0.90.9-0.90.9-1.41.6
Bone: minimum diameter0.61.23.6-0.21.2-0.30.31.1-1.11.1-1.1-1.61.9
Time in familiar zone, hab. session 10.40.41.8-0.9-0.20.1-0.0-0.40.4-0.40.41.0-1.3
Time in novel zone, hab. session 10.20.20.70.7-0.20.3-0.3-0.20.2-0.20.2-0.80.8
Total zone transitions, hab. session 11.31.83.60.30.81.2-1.2-1.91.9-1.91.90.2-0.5
Total locomotion distance, hab. session 11.31.93.3-0.21.31.3-1.3-1.81.8-1.81.8-0.1-0.2
Locomotion velocity, hab. session 11.21.72.9-0.31.01.3-1.3-1.71.7-1.71.70.2-0.4
Time in familiar zone, hab. session 20.30.32.0-0.6-0.5-0.20.20.3-0.30.3-0.30.5-1.4
Time in novel zone, hab. session 20.10.10.60.0-0.6-0.20.20.0-0.00.0-0.0-0.20.7
Total zone transitions, hab. session 20.30.30.80.70.90.2-0.2-0.70.7-0.70.7-0.6-0.0
Total locomotion distance, hab. session 20.91.23.00.31.70.7-0.7-1.31.3-1.31.3-0.80.1
Locomotion velocity, hab. session 21.41.84.30.22.11.1-1.1-1.61.6-1.61.6-0.90.2
Novel to familiar place preference ratio0.20.30.50.6-0.1-0.10.1-0.70.7-0.70.70.5-0.1
Novelty place preference0.20.30.60.3-0.20.1-0.0-0.80.8-0.80.80.5-0.1
Time in novel zone, NPP test0.20.20.5-0.0-0.40.10.0-0.70.7-0.70.70.4-0.2
Total zone transitions, NPP test1.42.13.3-0.51.81.3-1.3-1.81.8-1.81.8-0.90.5
Total locomotion distance, NPP test0.81.12.80.41.70.4-0.5-1.21.2-1.21.2-1.21.0
Locomotion velocity, NPP test1.01.54.30.92.10.5-0.5-1.31.3-1.31.3-1.01.0
Intraocular pressure0.30.40.6-0.50.1-0.70.80.8-0.80.8-0.8-0.70.0
Delta distance traveled before/after self-admin0.50.62.8-0.5-1.7-0.10.10.3-0.30.3-0.31.2-0.9
Delta ambulatory time before/after self-admin0.30.51.8-0.7-1.3-0.50.40.5-0.50.5-0.50.7-0.8
Parametrial fat weight3.07.212.21.3-1.3-3.13.13.5-3.53.5-3.5-0.3-0.3
Pavlov. Cond. lever latency5.26.610.02.0-2.8-3.23.22.8-2.82.8-2.81.2-1.3
Pavlov. Cond. magazine entry latency3.64.69.5-3.11.52.6-2.6-2.32.3-2.32.3-0.40.1
Pavlov. Cond. change in total contacts1.01.02.2-1.40.61.5-1.5-1.01.0-1.01.00.10.1
Pavlov. Cond. index score4.76.09.3-2.52.43.1-3.1-2.62.6-2.62.6-0.91.0
Pavlov. Cond. latency score4.45.68.8-2.52.53.0-3.0-2.52.5-2.52.5-0.90.9
Pavlov. Cond. lever contacts3.94.77.2-1.32.72.6-2.6-2.22.2-2.22.2-1.41.7
Pavlov. Cond. magazine entry number3.03.85.32.3-1.4-2.32.32.2-2.22.2-2.20.3-0.2
Pavlov. Cond. intertrial magazine entries0.91.12.41.5-1.2-1.51.50.7-0.70.7-0.70.7-0.4
Pavlov. Cond. lever-magazine prob. diff.4.86.09.4-2.42.43.1-3.1-2.62.6-2.62.6-0.91.0
Pavlov. Cond. response bias4.75.98.5-2.42.12.9-2.9-2.72.7-2.72.7-1.11.0
Pavlov. Cond. lever latency0.91.32.11.40.6-0.90.91.1-1.11.1-1.1-1.51.3
Pavlov. Cond. magazine entry latency0.20.41.5-1.20.60.3-0.30.4-0.40.4-0.4-0.50.7
Pavlov. Cond. change in total contacts0.30.82.9-1.3-0.60.6-0.6-0.30.3-0.30.31.7-1.2
Pavlov. Cond. index score0.30.52.7-1.70.00.8-0.8-0.40.4-0.40.40.6-0.3
Pavlov. Cond. latency score0.30.42.4-1.6-0.10.7-0.8-0.30.3-0.30.30.6-0.3
Pavlov. Cond. lever contacts0.60.92.2-1.1-0.60.6-0.6-0.90.9-0.90.91.5-1.2
Pavlov. Cond. magazine entry number0.20.20.40.6-0.20.2-0.2-0.70.7-0.70.70.0-0.3
Pavlov. Cond. intertrial magazine entries0.30.51.3-1.11.20.9-0.9-0.40.4-0.40.4-0.70.1
Pavlov. Cond. lever-magazine prob. diff.0.30.42.4-1.5-0.00.7-0.7-0.20.2-0.20.20.7-0.3
Pavlov. Cond. response bias0.60.93.0-1.70.10.9-0.9-0.90.9-0.90.90.8-0.6
Time in closed arm before self-admin0.10.10.60.40.30.2-0.2-0.10.1-0.10.1-0.80.5
Time in closed arm after self-admin0.50.50.90.9-0.10.5-0.6-0.90.9-0.90.90.40.3
Time in open arm before self-admin0.60.81.6-0.90.20.9-0.9-0.90.9-0.90.91.3-0.6
Time in open arm after self-admin0.50.53.3-1.8-0.10.4-0.4-0.50.5-0.50.5-0.2-0.5
Bone: periosteal estimation0.30.81.5-0.60.2-0.20.21.1-1.11.1-1.1-0.81.2
Bone: periosteal perimeter0.20.40.7-0.30.5-0.10.20.8-0.80.8-0.8-0.30.7
Bone: post-yield work0.81.34.6-0.71.20.3-0.30.9-0.90.9-0.9-2.11.9
Progressive ratio test 1 active lever presses0.10.20.60.3-0.20.6-0.5-0.50.5-0.50.5-0.10.8
Progressive ratio test 1 breakpoint0.20.30.70.3-0.20.6-0.5-0.60.6-0.60.6-0.10.8
Progressive ratio test 1 inactive lever presses0.30.93.51.9-0.3-1.11.10.8-0.80.8-0.80.2-0.0
Progressive ratio test 2 active lever presses0.10.20.4-0.30.20.6-0.6-0.50.5-0.50.5-0.10.2
Progressive ratio test 2 breakpoint0.20.20.4-0.50.10.6-0.6-0.50.5-0.50.5-0.00.1
Progressive ratio test 2 inactive lever presses0.30.81.70.10.91.0-0.9-1.01.0-1.01.0-0.61.3
Incentive Sensitization - Responses0.10.41.0-1.00.80.8-0.9-0.40.4-0.40.4-0.3-0.3
Incentive Sensitization - Breakpoint0.10.31.0-1.00.80.6-0.7-0.20.2-0.20.2-0.3-0.4
Sum of active levers in priming session hrs 5-60.20.10.20.00.30.5-0.3-0.40.4-0.40.40.40.2
Progressive ratio1.44.17.01.6-2.7-1.91.92.1-2.12.1-2.11.7-1.8
Food seeking constrained by brief footshock0.30.42.60.2-0.90.0-0.10.2-0.20.2-0.21.6-0.5
Seeking ratio, punishment vs. effort1.22.63.8-1.01.61.8-1.8-2.02.0-2.02.0-0.10.9
Retroperitoneal fat weight0.20.81.30.8-0.2-1.21.01.1-1.11.1-1.1-0.30.3
Reaction time number correct0.51.94.32.1-1.7-1.21.31.1-1.11.1-1.11.3-1.4
Reaction time mean minus median0.42.510.3-3.21.91.3-1.30.1-0.10.1-0.1-2.01.8
Reaction time mean minus median AUC0.42.67.8-2.81.91.5-1.50.0-0.00.0-0.0-2.12.3
Reaction time num false alarms0.10.21.1-1.00.50.3-0.4-0.30.3-0.30.3-0.1-0.3
Reaction time num false alarms AUC0.20.51.2-1.10.40.6-0.7-0.70.7-0.70.70.3-0.6
Reaction time trials correct on left0.51.94.32.1-1.7-1.21.31.1-1.11.1-1.11.3-1.4
Reaction time trials on left0.51.84.02.0-1.7-1.21.31.2-1.21.2-1.21.2-1.3
Reaction time mean1.12.47.4-1.32.20.6-0.60.7-0.70.7-0.7-2.62.7
Reaction time mean AUC1.02.36.8-1.42.00.5-0.50.9-0.90.9-0.9-2.52.6
Median of all reaction times1.21.86.0-0.31.80.2-0.20.9-0.90.9-0.9-2.32.5
Reaction time omissions0.91.44.4-1.11.90.3-0.30.7-0.70.7-0.7-2.11.6
Reaction time false alarm rate1.41.94.4-2.11.31.5-1.5-1.51.5-1.51.5-0.40.2
Reaction time premature initiation rate0.10.10.30.5-0.1-0.50.40.4-0.40.4-0.40.20.3
Reaction time premature initiations0.51.53.11.8-1.2-1.31.21.2-1.21.2-1.20.9-0.5
Std. dev. reaction times0.82.59.2-3.02.01.3-1.40.1-0.10.1-0.1-2.02.1
Reaction time trials completed0.51.84.02.0-1.7-1.21.31.2-1.21.2-1.21.2-1.3
Reaction time trials AUC0.51.94.52.1-1.6-1.31.41.2-1.21.2-1.21.1-1.2
Run reversals in cocaine runway, females0.20.20.70.6-0.80.2-0.2-0.00.0-0.00.00.80.2
Run reversals in cocaine runway, males1.71.98.1-2.81.41.3-1.3-0.80.8-0.80.8-1.50.8
Latency to leave start box in cocaine runway0.81.24.12.01.70.5-0.5-0.80.8-0.80.8-0.21.2
Latency to leave start box in cocaine runway, F0.50.61.71.31.30.4-0.4-0.60.6-0.60.6-0.40.9
Latency to leave start box in cocaine runway, M0.50.53.01.70.80.0-0.1-0.30.3-0.30.30.40.7
Std. dev. time between licks in bursts2.24.27.0-1.52.62.6-2.6-1.61.6-1.61.6-2.22.0
Total sessions with >9 infusions0.40.61.4-1.2-1.00.6-0.5-0.70.7-0.70.70.6-0.3
Short access day 1 total inactive lever presses0.40.81.9-1.00.41.4-1.4-0.50.5-0.50.5-0.41.2
Short access day 10 total inactive lever presses0.10.51.61.01.3-0.70.70.5-0.50.5-0.50.2-0.8
Short access day 1 total infusions0.30.71.2-0.2-0.11.1-1.1-0.90.9-0.90.90.30.7
Short access day 10 total infusions0.10.20.8-0.9-0.60.2-0.0-0.10.1-0.10.10.3-0.5
Short access total infusions0.20.20.4-0.5-0.50.6-0.5-0.50.5-0.50.50.30.3
Short access day 1 locomotion0.10.21.20.11.10.5-0.5-0.30.3-0.30.30.00.3
Short access day 10 total locomotion0.00.10.5-0.30.00.10.20.3-0.30.3-0.3-0.70.3
Short access total locomotion0.10.10.50.00.3-0.10.30.1-0.10.1-0.1-0.70.7
One hour access (0.3 mA shock)1.61.92.4-1.41.51.5-1.5-1.51.5-1.51.5-1.10.0
Compulsive drug intake1.21.89.40.63.10.8-0.8-0.10.1-0.10.1-2.21.5
One hour access (shock baseline)0.51.34.4-2.1-1.10.6-0.6-1.21.2-1.21.20.6-0.7
Social response proportion0.00.00.10.1-0.4-0.10.1-0.10.1-0.10.1-0.10.4
Social responses0.00.00.1-0.1-0.40.00.00.2-0.20.2-0.20.2-0.3
Social time0.91.45.1-1.62.20.8-0.8-0.00.0-0.00.0-2.00.8
Soleus weight1.75.014.0-2.12.42.3-2.2-1.11.1-1.11.1-3.33.7
Bone: stiffness0.91.72.61.1-0.9-1.61.61.6-1.61.6-1.60.0-0.4
Tibialis anterior weight0.00.10.4-0.4-0.4-0.20.2-0.30.3-0.30.30.5-0.6
Time to tail flick, vehicle, before self-admin1.01.31.9-0.40.9-1.21.01.3-1.31.3-1.3-1.4-0.4
Time to tail flick, vehicle, after self-admin0.10.10.5-0.60.70.10.0-0.00.0-0.00.0-0.50.5
Time to tail flick, test, before self-admin0.40.52.5-1.2-0.40.1-0.1-0.30.3-0.30.30.6-1.6
Time to tail flick, test, after self-admin1.11.15.5-2.40.81.3-1.3-0.50.5-0.50.50.1-0.8
Delta time to tail flick, vehicle, before/after SA0.70.81.4-0.2-0.20.7-0.5-1.21.2-1.21.21.10.2
Delta time to tail flick, test, before/after SA0.10.10.50.60.70.1-0.10.3-0.30.3-0.3-0.10.4
Tibia length0.82.14.3-0.20.3-0.40.42.1-2.12.1-2.1-1.41.3
Ambulatory time before self-admin0.10.20.60.30.80.2-0.10.5-0.50.5-0.5-0.40.2
Ambulatory time after self-admin0.30.51.0-0.2-0.5-0.40.41.0-1.01.0-1.0-0.0-0.5
Bone: tissue strength0.20.20.40.6-0.6-0.30.30.5-0.50.5-0.5-0.60.6
Total heroin consumption0.30.30.70.20.4-0.10.20.9-0.90.9-0.90.1-0.5
Bone: trabecular number0.10.20.9-0.70.9-0.30.3-0.20.2-0.20.2-0.5-0.3
Bone: trabecular spacing0.60.92.20.8-1.5-0.40.41.1-1.11.1-1.10.90.2
Bone: trabecular thickness0.40.51.3-0.71.1-0.70.70.6-0.60.6-0.6-1.00.3
Bone: trabecular tissue density0.50.91.8-1.2-0.41.4-1.4-0.80.8-0.80.81.1-0.4
Water consumed over 24 hours0.10.10.4-0.30.60.0-0.0-0.20.2-0.20.2-0.60.6
Number of responses in last shaping day3.34.27.50.60.22.7-2.7-2.52.5-2.52.50.61.6