Hub : Genes

Grb7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver alternative TSS NM_053403.2 0.08 0.09 2.8e-07 0.03 0.04 0.04 0.03 1.5e-04 2.7e-05 4.5e-05 1.5e-04
2 NAcc gene expression Grb7 0.03 0.02 1.9e-03 0 0.02 0 0 8.6e-02 4.0e-03 1.2e-01 6.8e-02
3 Liver isoform ratio XM_006247433.4 0.02 0.02 2.1e-03 0.01 0.02 0.01 0.01 1.6e-02 4.1e-03 2.3e-02 2.3e-02
4 PL gene expression Grb7 0.03 0.02 4.5e-04 0.02 0.02 -0 0.02 1.3e-03 1.2e-03 5.6e-01 5.8e-03
5 Liver isoform ratio NM_053403.2 0.02 0.02 1.5e-03 0 0.02 0 0 1.0e-01 3.7e-03 7.9e-02 9.0e-02
6 Liver alternative TSS NM_053403.2 0.08 0.08 1.2e-07 0.03 0.04 0.04 0.04 8.2e-04 2.9e-05 2.1e-05 7.6e-05
7 Liver mRNA stability Grb7 0.03 0.02 2.3e-04 0.03 0.01 0.01 0.02 3.9e-04 1.1e-02 1.3e-02 3.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density2.44.14.5-2.02.12.12.1-2.11.6-2.1
Area under the delay curve0.40.40.5-0.60.70.70.7-0.70.6-0.3
BMI with tail2.47.99.33.1-2.9-2.8-2.72.6-2.92.8
BMI without tail0.10.20.40.5-0.3-0.4-0.40.3-0.60.6
Body weight6.326.430.25.5-5.4-5.3-5.25.0-4.94.6
Weight adjusted by age0.20.20.40.5-0.6-0.5-0.50.4-0.50.2
Bone surface0.00.00.00.1-0.00.00.1-0.1-0.2-0.1
Bone volume0.10.20.3-0.20.30.40.5-0.60.1-0.5
Breakpoint value in progressive ratio session0.20.20.50.4-0.7-0.5-0.50.5-0.1-0.5
Number of licking bursts0.20.20.4-0.40.50.60.6-0.70.3-0.4
Context. condit. distance diff. score1.11.32.50.9-0.9-1.0-1.11.2-1.21.6
Locomotion velocity, session 10.50.50.80.8-0.9-0.8-0.80.7-0.40.5
Locomotion distance, session 13.14.05.02.2-2.2-2.1-2.01.9-1.91.4
Locomotion velocity, session 20.20.30.40.5-0.6-0.6-0.60.6-0.50.3
Locomotion distance, session 20.40.50.90.9-1.0-0.8-0.70.6-0.6-0.0
Locomotion velocity, session 30.00.00.1-0.0-0.0-0.1-0.10.1-0.0-0.2
Locomotion distance, session 30.30.30.40.6-0.6-0.6-0.60.6-0.60.4
Stereotopy head waving bouts, day 33.03.64.5-2.02.12.02.0-1.91.6-1.5
Stereotopy head waving duration, day 30.20.20.4-0.50.60.50.5-0.50.2-0.1
Locomotion velocity, session 71.21.31.61.2-1.3-1.1-1.21.1-1.11.2
Locomotion distance, session 70.30.40.60.6-0.7-0.6-0.70.6-0.50.8
Stereotopy head waving bouts, day 70.60.70.9-0.80.90.90.9-1.00.3-0.7
Stereotopy head waving duration, day 70.20.30.4-0.50.60.60.6-0.60.2-0.5
Locomotion velocity, session 88.410.010.23.2-3.2-3.2-3.23.2-3.13.1
Locomotion distance, session 81.52.32.51.6-1.6-1.5-1.51.5-1.51.3
Degree of sensitization distance0.90.91.50.9-0.9-0.9-0.90.9-0.81.2
Degree of sensitization stereotypy1.01.11.5-1.11.21.21.2-1.20.6-1.0
Conditioned locomotion0.10.20.3-0.50.40.40.3-0.30.5-0.4
Cocaine response after cond. corrected1.11.31.8-1.01.11.21.2-1.40.9-0.9
Cocaine response after cond. not corrected1.61.82.6-1.31.41.51.4-1.61.1-1.1
Cocaine response before conditioning0.30.30.5-0.60.70.60.6-0.60.4-0.3
Saline control response0.10.10.30.2-0.1-0.1-0.10.0-0.50.6
Bone: connectivity density3.55.56.1-2.42.42.42.4-2.42.0-2.5
Bone: cortical apparent density7.09.310.5-3.23.23.13.1-2.93.2-2.6
Bone: cortical area0.10.10.2-0.40.40.40.4-0.40.3-0.2
Bone: cortical porosity0.20.20.4-0.40.40.50.5-0.60.4-0.2
Bone: cortical porosity0.10.20.3-0.30.40.50.5-0.60.2-0.1
Bone: cortical thickness1.32.22.7-1.61.71.61.5-1.51.2-1.2
Bone: cortical thickness6.27.27.9-2.82.72.72.7-2.62.8-2.5
Bone: cortical tissue density7.19.310.5-3.23.23.13.1-2.93.2-2.6
Condit. Reinf. active minus inactive responses0.91.01.2-1.11.01.01.0-0.90.9-1.1
Condit. Reinf. active-inactive response ratio1.11.21.6-1.31.21.11.0-0.91.0-1.1
Condit. Reinf. active responses1.01.21.5-1.21.21.11.1-1.01.1-1.1
Condit. Reinf. inactive responses0.20.30.4-0.50.50.60.5-0.60.5-0.4
Incentive salience index mean2.12.52.7-1.61.61.61.6-1.51.6-1.6
Condit. Reinf. lever presses1.11.51.6-1.21.21.21.3-1.31.2-1.1
Condit. Reinf. active minus inactive responses1.01.31.9-1.11.01.11.1-1.11.2-1.4
Condit. Reinf. active-inactive response ratio0.80.81.4-0.80.70.80.9-0.90.9-1.2
Condit. Reinf. active responses1.62.33.2-1.41.31.41.5-1.51.6-1.8
Condit. Reinf. inactive responses2.12.62.8-1.51.51.61.6-1.61.7-1.6
Condit. Reinf. lever presses0.10.10.2-0.30.30.30.3-0.30.5-0.4
Condit. Reinf. lever reinforcers received1.72.33.2-1.41.31.41.5-1.51.7-1.8
Conditioned reinforcement - actives0.80.81.0-1.00.90.90.9-0.90.8-0.7
Conditioned reinforcement - inactives2.22.43.4-1.61.51.41.5-1.41.9-1.7
Conditioned locomotion0.60.70.9-0.90.90.90.9-0.90.4-0.6
Patch foraging indifference point 0 sec1.93.13.6-1.91.91.81.7-1.71.7-1.6
Patch foraging indifference point AUC0.00.00.00.1-0.1-0.1-0.20.10.00.0
Delay disc. indifference point, 0s delay1.11.31.4-1.21.21.21.2-1.21.0-0.9
Delay disc. indifference point, 16s delay0.50.50.9-0.90.90.80.7-0.60.7-0.2
Delay disc. indifference point, 2s delay1.31.41.9-1.11.21.31.3-1.40.9-0.9
Delay disc. indifference point, 24s delay0.00.00.2-0.00.20.00.00.0-0.00.4
Delay disc. indifference point, 4s delay0.80.80.9-0.90.90.90.9-0.91.0-0.9
Delay disc. indifference point, 8s delay0.20.20.3-0.40.50.50.4-0.50.5-0.2
Indifference point function ln k0.00.00.1-0.10.20.00.00.0-0.20.3
Indifference point function log k0.00.00.1-0.10.20.00.00.0-0.20.3
Patch foraging total patch changes 0 sec1.42.22.5-1.61.61.51.5-1.41.4-1.4
Patch foraging total patch changes 12 sec5.97.68.3-2.72.72.72.7-2.72.8-2.9
Patch foraging total patch changes 18 sec0.60.80.9-0.90.90.90.9-0.80.8-0.9
Patch foraging total patch changes 24 sec2.02.42.8-1.71.61.61.6-1.61.3-1.4
Patch foraging total patch changes 6 sec2.33.43.6-1.91.91.81.9-1.81.9-1.7
Patch foraging time to switch 0 sec0.10.10.2-0.30.30.30.3-0.30.3-0.4
Patch foraging water rate 0 sec0.00.00.1-0.10.10.10.1-0.10.4-0.3
Patch foraging water rate 12 sec0.10.10.20.3-0.4-0.4-0.40.4-0.20.1
Patch foraging water rate 18 sec0.40.60.7-0.70.70.80.8-0.90.6-0.8
Patch foraging water rate 24 sec0.50.71.2-0.80.80.80.9-0.81.1-0.8
Patch foraging water rate 6 sec1.62.33.4-1.41.41.41.4-1.41.8-1.7
Seeking ratio, delayed vs. immediate footshock0.20.20.5-0.70.50.40.4-0.20.7-0.4
Distance traveled before self-admin0.10.10.20.3-0.4-0.3-0.30.30.30.1
Distance traveled after self-admin1.71.92.21.5-1.5-1.5-1.41.4-1.01.3
Extensor digitorum longus weight9.938.939.76.2-6.2-6.3-6.36.3-6.26.2
Bone: elastic displacement0.00.00.0-0.10.10.10.1-0.1-0.10.0
Bone: elastic work0.00.00.2-0.10.10.10.2-0.20.1-0.4
Bone: endosteal estimation2.55.46.42.5-2.5-2.4-2.32.2-2.22.1
Bone: endosteal perimeter1.63.24.01.9-2.0-1.9-1.91.8-1.31.6
Epididymis fat weight0.20.40.70.7-0.9-0.7-0.70.6-0.00.1
Delta time in closed arm before/after self-admin4.24.14.62.1-2.1-2.0-2.02.0-2.11.8
Delta time in open arm before/after self-admin0.00.00.0-0.10.20.10.1-0.10.10.1
Diff in mean of infusions in LGA sessions0.20.20.40.4-0.6-0.5-0.50.5-0.3-0.3
Delay discount exponential model param0.20.20.20.4-0.5-0.4-0.40.4-0.40.1
Extinction: sum of active levers before priming1.71.61.91.4-1.3-1.3-1.31.2-1.31.2
Active lever presses in extinction session 60.90.91.5-0.60.60.80.9-1.01.1-1.2
Bone: final force0.60.91.4-0.81.01.11.1-1.20.6-0.8
Bone: final moment0.40.61.1-0.60.80.90.9-1.00.4-0.7
Food consumed during 24 hour testing period0.91.11.21.1-1.1-1.0-1.01.0-1.11.1
Glucose0.20.20.4-0.50.50.60.6-0.60.40.0
Heart weight4.05.76.42.4-2.3-2.3-2.32.3-2.52.5
Delay discount hyperbolic model param0.30.30.40.5-0.6-0.6-0.60.6-0.50.2
Intermittent access intake day 1-15 change0.40.40.7-0.60.50.50.6-0.50.7-0.8
Intermittent access intake escalation0.40.30.7-0.50.40.50.5-0.50.7-0.8
Intermittent access intake escalation 20.00.00.10.1-0.1-0.1-0.00.00.2-0.3
Intermitt. access day 1 inactive lever presses1.82.03.1-1.21.21.21.3-1.31.8-1.8
Intermitt. access day 15 inactive lever presses4.85.25.8-2.32.32.32.3-2.22.4-2.3
Intermitt. access escalation Index1.91.72.11.3-1.2-1.2-1.31.2-1.51.4
Intermittent access day 1 total infusions0.20.20.3-0.40.30.40.4-0.40.6-0.5
Intermittent access day 15 total infusions0.60.61.0-0.80.70.70.7-0.70.9-1.0
Intermittent access terminal intake (last 3 days)0.70.81.2-0.80.70.80.8-0.81.1-1.1
Intermittent access total infusions0.20.20.5-0.40.20.30.3-0.30.7-0.7
Intermittent access day 1 locomotion0.30.30.4-0.60.60.60.5-0.50.4-0.4
Intermittent access day 15 total locomotion0.40.40.6-0.70.70.70.7-0.70.4-0.6
Intermittent access total locomotion0.80.91.1-1.01.01.00.9-0.90.8-0.9
Intermittent access standard deviation1.92.04.1-1.31.11.11.2-1.11.7-2.0
Left kidney weight1.44.14.82.0-2.0-2.1-2.12.2-1.81.8
Right kidney weight0.20.70.90.9-1.0-0.9-0.90.9-0.70.4
Cocaine induced anxiety2.42.73.61.9-1.8-1.7-1.61.5-1.51.4
Post-drug Anxiety0.20.20.30.5-0.4-0.4-0.40.3-0.50.5
Baseline Anxiety2.12.33.0-1.71.71.61.6-1.51.2-1.0
Tail length0.31.01.41.0-1.1-1.1-1.11.2-0.70.7
Length with tail3.512.814.83.7-3.8-3.8-3.73.7-3.22.9
Length without tail4.59.912.03.4-3.5-3.3-3.23.2-2.82.6
Times rat made contact with spout1.01.11.4-1.01.11.11.2-1.20.8-0.9
Lifetime Intake0.20.20.6-0.40.30.30.4-0.30.7-0.8
Liver weight, left0.00.00.00.0-0.1-0.1-0.10.10.2-0.2
Liver weight, right0.30.61.1-0.70.60.60.6-0.61.1-1.0
Locomotor activity0.50.91.2-0.80.80.90.9-1.00.9-1.1
Locomotor testing distance2.54.14.4-2.02.02.12.0-2.11.9-2.0
Locomotor testing rearing6.810.511.5-3.43.43.33.2-3.23.2-3.1
Locomotion in novel chamber6.37.88.6-2.92.92.92.9-2.92.5-2.4
Locomotion in novel chamber post-restriction0.81.01.4-0.80.81.01.1-1.20.9-1.0
Fecal boli incidents, locomotor time 10.30.30.50.5-0.5-0.5-0.50.4-0.70.7
Change in fecal boli incidents, locomotor task0.00.00.1-0.00.00.00.0-0.0-0.30.1
Time >=10cm from walls, locomotor time 10.30.30.6-0.80.80.70.6-0.50.2-0.3
Bouts of movement, locomotor time 10.60.70.80.9-0.9-0.9-0.90.8-0.70.4
Total resting periods, locomotor time 11.21.31.61.3-1.3-1.2-1.21.1-1.10.7
Rest time, locomotor task time 10.00.00.00.1-0.00.00.0-0.10.1-0.1
Distance moved, locomotor task time 10.10.10.2-0.40.40.40.4-0.40.4-0.0
Vertical activity count, locomotor time 10.10.10.20.3-0.4-0.3-0.30.3-0.40.3
Time >=10cm from walls, locomotor time 21.51.62.0-1.41.31.31.2-1.30.9-1.2
Bouts of movement, locomotor time 20.20.20.4-0.50.40.30.3-0.20.6-0.6
Total resting periods, locomotor time 20.10.10.2-0.30.20.10.1-0.00.4-0.4
Rest time, locomotor task time 21.01.21.31.1-1.1-1.1-1.11.1-1.10.8
Distance moved, locomotor task time 20.00.00.30.1-0.1-0.0-0.00.0-0.10.5
Vertical activity count, locomotor time 20.20.20.40.4-0.4-0.4-0.40.4-0.60.6
Light reinforcement 13.05.47.2-2.22.22.22.3-2.22.4-2.7
Light reinforcement 20.60.81.0-0.70.80.90.9-1.00.7-1.0
Bone: marrow area2.35.06.02.4-2.4-2.3-2.22.1-2.12.0
Bone: maximum diameter0.00.00.1-0.10.10.20.2-0.20.2-0.2
Bone: maximum force0.00.00.20.2-0.1-0.0-0.0-0.1-0.40.3
Bone: maximum moment0.10.10.40.4-0.3-0.2-0.20.1-0.60.4
Mean time between licks in bursts1.31.92.21.5-1.5-1.4-1.41.4-1.21.2
Mean num. licks in bursts0.10.10.1-0.30.40.30.3-0.30.3-0.2
Cd content in liver0.10.10.1-0.20.30.30.3-0.30.0-0.2
Co content in liver0.70.81.10.9-0.9-1.0-0.91.0-0.90.7
Cu content in liver0.10.10.20.2-0.4-0.4-0.40.40.10.0
Fe content in liver1.31.51.81.3-1.3-1.3-1.21.2-1.21.0
K content in liver1.41.42.2-1.11.01.01.0-1.01.4-1.5
Mg content in liver1.31.31.9-1.31.11.01.0-0.91.4-1.3
Mn content in liver2.22.53.5-1.61.51.51.5-1.41.8-1.9
Na content in liver0.30.30.6-0.40.30.50.5-0.60.6-0.7
Rb content in liver1.61.92.0-1.41.41.41.4-1.41.4-1.3
Se content in liver5.66.89.7-2.62.52.52.5-2.43.1-2.7
Sr content in liver0.00.00.1-0.20.10.00.10.00.4-0.3
Zn content in liver3.23.54.0-1.91.81.81.9-1.82.0-2.0
Bone: minimum diameter0.61.01.31.1-1.1-1.0-1.01.0-0.91.0
Time in familiar zone, hab. session 10.20.20.5-0.30.40.50.6-0.70.5-0.2
Time in novel zone, hab. session 10.70.71.1-1.01.10.90.8-0.70.6-0.6
Total zone transitions, hab. session 12.02.82.91.7-1.7-1.7-1.71.7-1.61.7
Total locomotion distance, hab. session 10.00.00.00.1-0.1-0.1-0.10.1-0.20.2
Locomotion velocity, hab. session 10.40.50.60.7-0.8-0.8-0.70.8-0.60.5
Time in familiar zone, hab. session 20.50.50.6-0.60.60.70.7-0.80.7-0.8
Time in novel zone, hab. session 20.20.20.2-0.50.50.40.4-0.30.5-0.4
Total zone transitions, hab. session 20.91.21.41.2-1.1-1.1-1.11.0-1.11.0
Total locomotion distance, hab. session 20.20.30.60.7-0.6-0.5-0.50.4-0.80.3
Locomotion velocity, hab. session 20.50.61.00.9-0.9-0.8-0.80.7-1.00.5
Novel to familiar place preference ratio1.11.11.40.9-1.0-1.1-1.21.2-0.81.0
Novelty place preference0.80.81.10.7-0.8-0.9-1.01.0-0.70.9
Time in novel zone, NPP test0.20.20.30.3-0.3-0.4-0.50.6-0.40.6
Total zone transitions, NPP test0.50.71.01.0-1.0-0.9-0.80.7-0.80.8
Total locomotion distance, NPP test0.00.00.10.2-0.1-0.00.0-0.1-0.30.0
Locomotion velocity, NPP test0.40.50.80.8-0.8-0.7-0.60.6-0.90.6
Intraocular pressure2.63.74.71.9-1.8-1.8-1.91.8-2.12.2
Delta distance traveled before/after self-admin1.61.72.21.3-1.2-1.3-1.31.3-1.51.3
Delta ambulatory time before/after self-admin1.11.21.91.1-0.9-1.0-1.01.0-1.41.1
Parametrial fat weight1.22.43.7-1.41.31.41.5-1.51.8-1.9
Pavlov. Cond. lever latency2.83.64.31.8-1.8-2.0-2.02.1-1.81.8
Pavlov. Cond. magazine entry latency10.914.014.9-3.73.83.83.9-3.93.6-3.6
Pavlov. Cond. change in total contacts9.710.411.6-3.43.43.33.3-3.23.2-2.8
Pavlov. Cond. index score8.711.012.3-3.33.33.43.5-3.53.1-3.1
Pavlov. Cond. latency score6.58.39.5-2.82.93.03.0-3.12.7-2.7
Pavlov. Cond. lever contacts2.32.73.4-1.51.61.71.8-1.81.6-1.5
Pavlov. Cond. magazine entry number13.616.918.24.1-4.2-4.2-4.34.3-3.83.8
Pavlov. Cond. intertrial magazine entries1.41.72.11.2-1.3-1.4-1.41.4-1.11.3
Pavlov. Cond. lever-magazine prob. diff.9.812.213.4-3.53.53.63.6-3.73.3-3.3
Pavlov. Cond. response bias10.112.313.2-3.53.63.63.6-3.63.3-3.2
Pavlov. Cond. lever latency0.30.40.60.6-0.6-0.6-0.70.7-0.80.7
Pavlov. Cond. magazine entry latency0.00.00.10.3-0.3-0.2-0.20.2-0.20.2
Pavlov. Cond. change in total contacts0.71.01.4-1.01.01.01.0-0.91.2-0.7
Pavlov. Cond. index score0.20.20.3-0.40.40.50.5-0.50.5-0.4
Pavlov. Cond. latency score0.10.10.1-0.20.30.30.4-0.40.3-0.2
Pavlov. Cond. lever contacts0.71.01.2-0.90.91.01.1-1.11.0-1.0
Pavlov. Cond. magazine entry number0.00.00.10.1-0.2-0.2-0.20.3-0.10.1
Pavlov. Cond. intertrial magazine entries1.31.82.41.1-1.2-1.4-1.41.5-1.21.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.1-0.20.20.30.3-0.40.3-0.2
Pavlov. Cond. response bias1.11.51.7-1.11.11.21.3-1.31.3-1.3
Time in closed arm before self-admin1.21.41.9-1.21.41.21.2-1.11.3-0.6
Time in closed arm after self-admin0.50.50.70.6-0.5-0.7-0.70.8-0.60.9
Time in open arm before self-admin2.32.53.31.6-1.8-1.7-1.71.6-1.61.0
Time in open arm after self-admin0.50.50.70.7-0.9-0.7-0.70.7-0.60.5
Bone: periosteal estimation0.30.60.80.9-0.8-0.7-0.70.6-0.70.7
Bone: periosteal perimeter0.81.31.71.3-1.3-1.2-1.11.0-0.91.1
Bone: post-yield work1.72.43.11.6-1.4-1.5-1.51.4-1.81.6
Progressive ratio test 1 active lever presses0.80.91.1-1.01.11.01.0-1.00.8-0.7
Progressive ratio test 1 breakpoint0.70.70.9-0.91.00.90.9-0.90.7-0.6
Progressive ratio test 1 inactive lever presses1.61.82.2-1.31.31.21.3-1.21.5-1.5
Progressive ratio test 2 active lever presses1.61.72.0-1.41.31.31.3-1.21.4-1.3
Progressive ratio test 2 breakpoint1.21.31.5-1.21.11.11.1-1.11.2-1.1
Progressive ratio test 2 inactive lever presses0.60.71.2-0.80.60.70.7-0.71.1-1.1
Incentive Sensitization - Responses1.81.82.3-1.41.31.31.3-1.31.5-1.4
Incentive Sensitization - Breakpoint1.71.72.2-1.31.21.31.3-1.31.5-1.3
Sum of active levers in priming session hrs 5-60.30.30.4-0.50.50.60.6-0.60.6-0.6
Progressive ratio0.10.10.3-0.20.10.20.2-0.20.6-0.6
Food seeking constrained by brief footshock0.20.30.6-0.40.40.50.5-0.50.8-0.6
Seeking ratio, punishment vs. effort0.00.00.1-0.10.30.20.2-0.2-0.10.2
Retroperitoneal fat weight0.10.20.40.6-0.5-0.5-0.50.5-0.10.3
Reaction time number correct0.81.11.51.2-1.2-1.1-1.11.0-0.90.9
Reaction time mean minus median0.30.31.00.5-0.5-0.5-0.50.5-1.00.4
Reaction time mean minus median AUC0.00.00.2-0.10.20.20.1-0.2-0.4-0.1
Reaction time num false alarms0.60.81.2-0.80.80.90.9-1.00.7-1.1
Reaction time num false alarms AUC0.40.61.1-0.60.60.70.7-0.80.6-1.0
Reaction time trials correct on left0.81.11.51.2-1.2-1.1-1.11.0-0.90.9
Reaction time trials on left0.81.11.41.1-1.2-1.1-1.01.0-0.90.9
Reaction time mean0.20.20.5-0.60.50.50.4-0.40.3-0.7
Reaction time mean AUC0.20.20.5-0.50.50.40.4-0.30.3-0.7
Median of all reaction times1.01.31.7-1.21.21.11.1-1.01.1-1.3
Reaction time omissions1.11.52.4-1.21.21.21.2-1.21.0-1.6
Reaction time false alarm rate1.01.41.8-1.11.11.21.2-1.21.0-1.3
Reaction time premature initiation rate0.30.40.8-0.60.50.60.6-0.60.3-0.9
Reaction time premature initiations0.10.10.30.3-0.4-0.3-0.20.2-0.5-0.0
Std. dev. reaction times0.00.00.2-0.00.00.00.0-0.0-0.4-0.1
Reaction time trials completed0.81.11.41.1-1.2-1.1-1.01.0-0.90.9
Reaction time trials AUC0.60.91.21.0-1.1-1.0-1.00.9-0.90.9
Run reversals in cocaine runway, females2.72.62.91.4-1.5-1.6-1.61.7-1.71.6
Run reversals in cocaine runway, males0.60.60.7-0.80.80.80.8-0.80.8-0.5
Latency to leave start box in cocaine runway2.02.12.41.5-1.6-1.5-1.51.5-1.11.4
Latency to leave start box in cocaine runway, F1.92.12.61.5-1.6-1.5-1.51.5-1.21.3
Latency to leave start box in cocaine runway, M0.10.00.2-0.20.20.10.2-0.10.4-0.1
Std. dev. time between licks in bursts0.10.10.20.4-0.4-0.4-0.30.3-0.2-0.0
Total sessions with >9 infusions0.80.91.0-1.01.00.90.9-0.90.9-0.9
Short access day 1 total inactive lever presses2.42.73.6-1.61.51.51.6-1.51.7-1.9
Short access day 10 total inactive lever presses0.20.20.30.5-0.6-0.5-0.50.5-0.3-0.2
Short access day 1 total infusions0.70.71.3-0.80.70.70.8-0.71.1-1.0
Short access day 10 total infusions0.40.40.7-0.60.50.60.6-0.60.8-0.8
Short access total infusions0.30.30.7-0.50.30.40.4-0.30.8-0.8
Short access day 1 locomotion4.14.45.3-2.12.12.02.1-2.02.3-2.2
Short access day 10 total locomotion1.61.82.0-1.41.41.41.4-1.41.3-1.2
Short access total locomotion0.50.60.7-0.80.80.70.7-0.60.8-0.8
One hour access (0.3 mA shock)0.00.00.0-0.10.00.00.00.00.1-0.1
Compulsive drug intake0.30.30.60.3-0.3-0.4-0.50.6-0.80.7
One hour access (shock baseline)0.30.40.8-0.50.40.50.5-0.50.9-0.7
Social response proportion0.30.30.70.5-0.3-0.4-0.40.4-0.80.9
Social responses0.00.00.1-0.00.10.20.2-0.30.1-0.0
Social time0.00.10.20.4-0.4-0.2-0.20.0-0.2-0.1
Soleus weight0.10.20.4-0.00.30.40.4-0.5-0.60.1
Bone: stiffness0.00.00.00.1-0.00.00.0-0.1-0.10.2
Tibialis anterior weight1.65.56.22.4-2.4-2.3-2.32.2-2.52.2
Time to tail flick, vehicle, before self-admin0.00.00.1-0.10.20.20.3-0.3-0.00.1
Time to tail flick, vehicle, after self-admin0.00.00.1-0.20.20.30.3-0.30.0-0.1
Time to tail flick, test, before self-admin1.61.62.41.2-1.2-1.2-1.21.2-1.61.1
Time to tail flick, test, after self-admin0.10.10.2-0.10.30.30.4-0.50.2-0.1
Delta time to tail flick, vehicle, before/after SA0.20.20.3-0.30.30.50.4-0.60.6-0.5
Delta time to tail flick, test, before/after SA2.92.63.0-1.61.71.71.7-1.71.7-1.3
Tibia length1.64.65.52.3-2.2-2.1-2.01.9-2.32.1
Ambulatory time before self-admin0.10.10.20.4-0.5-0.4-0.40.40.20.2
Ambulatory time after self-admin2.93.24.12.0-1.9-1.9-1.81.8-1.31.6
Bone: tissue strength1.01.01.81.0-0.9-0.9-0.90.9-1.31.0
Total heroin consumption1.61.93.4-1.11.01.21.3-1.31.6-1.8
Bone: trabecular number5.78.99.6-2.92.93.03.0-3.12.7-3.1
Bone: trabecular spacing1.52.02.41.6-1.6-1.4-1.41.3-1.11.4
Bone: trabecular thickness0.10.10.3-0.30.40.40.4-0.40.1-0.5
Bone: trabecular tissue density0.00.10.1-0.40.30.10.10.1-0.20.3
Water consumed over 24 hours0.10.10.30.3-0.2-0.2-0.10.1-0.50.5
Number of responses in last shaping day0.40.40.9-0.70.50.50.5-0.40.7-0.9