Hub : Genes

Grb7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Grb7	0.02	0.01	1.5e-03	0	0.01	0	0	6.5e-02	1.1e-02	2.0e-01	1.1e-01
2	PL	gene expression	Grb7	0.02	0.02	1.6e-03	0.02	0.02	0.02	0.01	5.8e-03	1.7e-03	6.3e-03	8.6e-03
3	Liver	mRNA stability	Grb7	0.02	0.02	2.8e-03	0.02	0.01	0	0.01	3.6e-03	4.4e-02	9.6e-02	2.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	2.4	4.3	4.8	2.0	2.1	-2.2
Area under the delay curve	0.4	0.6	0.9	1.0	0.8	-0.5
BMI with tail	2.4	8.4	9.3	-2.9	-3.1	2.7
BMI without tail	0.9	4.6	5.4	-2.3	-2.2	1.8
Body weight	7.6	33.1	37.6	-6.1	-6.0	5.1
Weight adjusted by age	0.1	0.1	0.2	-0.5	-0.5	0.0
Bone surface	0.0	0.0	0.1	0.0	0.1	-0.3
Bone volume	0.1	0.3	0.5	0.4	0.4	-0.7
Breakpoint value in progressive ratio session	0.4	0.8	1.6	-1.3	-0.8	-0.1
Number of licking bursts	0.1	0.2	0.3	0.6	0.5	-0.4
Context. condit. distance diff. score	1.0	1.3	2.1	-0.8	-1.0	1.4
Locomotion velocity, session 1	0.7	0.7	1.0	-1.0	-0.9	0.6
Locomotion distance, session 1	2.9	3.7	4.9	-2.2	-2.1	1.4
Locomotion velocity, session 2	0.3	0.4	0.5	-0.7	-0.6	0.4
Locomotion distance, session 2	0.3	0.5	0.9	-1.0	-0.7	0.1
Locomotion velocity, session 3	0.0	0.0	0.0	-0.2	-0.1	0.1
Locomotion distance, session 3	0.3	0.4	0.5	-0.7	-0.7	0.5
Stereotopy head waving bouts, day 3	3.0	3.5	4.6	2.1	2.0	-1.4
Stereotopy head waving duration, day 3	0.3	0.4	0.6	0.8	0.7	-0.2
Locomotion velocity, session 7	1.2	1.3	1.4	-1.2	-1.2	1.1
Locomotion distance, session 7	0.3	0.4	0.4	-0.6	-0.6	0.6
Stereotopy head waving bouts, day 7	0.9	1.1	1.5	1.2	1.1	-0.8
Stereotopy head waving duration, day 7	0.3	0.4	0.5	0.7	0.6	-0.5
Locomotion velocity, session 8	8.0	9.7	9.8	-3.1	-3.1	3.1
Locomotion distance, session 8	1.5	2.2	2.5	-1.6	-1.6	1.3
Degree of sensitization distance	0.7	0.7	1.0	-0.7	-0.8	1.0
Degree of sensitization stereotypy	1.1	1.2	1.7	1.3	1.1	-0.8
Conditioned locomotion	0.2	0.2	0.2	0.5	0.5	-0.4
Cocaine response after cond. corrected	0.9	1.3	2.0	1.4	1.2	-0.8
Cocaine response after cond. not corrected	1.2	1.7	2.5	1.6	1.3	-0.9
Cocaine response before conditioning	0.1	0.1	0.3	0.5	0.4	-0.2
Saline control response	0.3	0.4	0.8	-0.3	-0.6	0.9
Bone: connectivity density	3.6	5.7	6.0	2.3	2.4	-2.5
Bone: cortical apparent density	5.3	8.3	9.0	3.0	3.0	-2.7
Bone: cortical area	0.1	0.1	0.2	0.4	0.4	-0.3
Bone: cortical porosity	0.5	0.5	0.6	0.8	0.7	-0.7
Bone: cortical porosity	0.2	0.2	0.4	0.6	0.5	-0.3
Bone: cortical thickness	1.3	2.1	2.6	1.6	1.5	-1.2
Bone: cortical thickness	5.0	6.1	6.5	2.5	2.5	-2.4
Bone: cortical tissue density	5.2	8.3	9.0	3.0	3.0	-2.7
Condit. Reinf. active minus inactive responses	0.9	1.0	1.2	0.9	1.0	-1.1
Condit. Reinf. active-inactive response ratio	1.2	1.3	1.3	1.1	1.2	-1.1
Condit. Reinf. active responses	0.9	1.2	1.2	1.0	1.1	-1.1
Condit. Reinf. inactive responses	0.2	0.2	0.3	0.6	0.5	-0.3
Incentive salience index mean	1.8	2.3	2.5	1.5	1.6	-1.5
Condit. Reinf. lever presses	1.2	1.8	2.0	1.3	1.4	-1.3
Condit. Reinf. active minus inactive responses	0.8	1.2	1.6	0.9	1.0	-1.3
Condit. Reinf. active-inactive response ratio	0.6	1.0	1.5	0.8	0.9	-1.2
Condit. Reinf. active responses	1.3	1.9	2.6	1.1	1.3	-1.6
Condit. Reinf. inactive responses	1.3	1.9	2.1	1.3	1.4	-1.4
Condit. Reinf. lever presses	0.0	0.1	0.1	0.2	0.2	-0.3
Condit. Reinf. lever reinforcers received	1.4	2.0	2.7	1.2	1.4	-1.6
Conditioned reinforcement - actives	0.0	0.1	0.2	0.5	0.4	-0.1
Conditioned reinforcement - inactives	0.1	0.2	0.4	0.2	0.4	-0.6
Conditioned locomotion	0.6	0.9	1.3	1.1	1.0	-0.7
Patch foraging indifference point 0 sec	1.0	2.8	3.1	1.7	1.8	-1.6
Patch foraging indifference point AUC	0.0	0.0	0.0	0.0	-0.0	0.1
Delay disc. indifference point, 0s delay	1.9	2.2	2.5	1.6	1.5	-1.3
Delay disc. indifference point, 16s delay	0.3	0.5	0.8	0.9	0.7	-0.3
Delay disc. indifference point, 2s delay	1.4	1.6	2.1	1.4	1.3	-1.1
Delay disc. indifference point, 24s delay	0.0	0.1	0.2	0.1	-0.1	0.4
Delay disc. indifference point, 4s delay	1.0	1.1	1.1	1.0	1.0	-1.0
Delay disc. indifference point, 8s delay	0.1	0.2	0.4	0.6	0.5	-0.2
Indifference point function ln k	0.0	0.0	0.1	0.1	0.0	0.3
Indifference point function log k	0.0	0.0	0.1	0.1	0.0	0.3
Patch foraging total patch changes 0 sec	0.6	1.8	2.0	1.4	1.4	-1.2
Patch foraging total patch changes 12 sec	5.0	6.7	7.3	2.5	2.6	-2.7
Patch foraging total patch changes 18 sec	0.2	0.4	0.4	0.6	0.6	-0.6
Patch foraging total patch changes 24 sec	0.5	1.8	2.2	1.5	1.4	-1.1
Patch foraging total patch changes 6 sec	1.4	2.4	2.6	1.6	1.6	-1.5
Patch foraging time to switch 0 sec	0.0	0.1	0.2	0.2	0.2	-0.5
Patch foraging water rate 0 sec	0.0	0.1	0.1	0.2	0.3	-0.3
Patch foraging water rate 12 sec	0.0	0.2	0.3	-0.6	-0.4	0.1
Patch foraging water rate 18 sec	0.3	0.7	1.0	0.8	0.8	-1.0
Patch foraging water rate 24 sec	0.4	0.6	0.7	0.7	0.8	-0.8
Patch foraging water rate 6 sec	1.4	2.1	2.7	1.3	1.4	-1.6
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	-0.2	-0.1	0.1
Distance traveled before self-admin	0.0	0.1	0.2	-0.4	-0.1	-0.3
Distance traveled after self-admin	0.6	1.0	1.3	-1.1	-1.0	0.8
Extensor digitorum longus weight	10.1	40.2	41.2	-6.2	-6.4	6.4
Bone: elastic displacement	0.0	0.0	0.0	0.2	0.1	0.1
Bone: elastic work	0.0	0.1	0.1	0.1	0.2	-0.3
Bone: endosteal estimation	2.1	5.1	5.5	-2.4	-2.3	2.1
Bone: endosteal perimeter	1.5	3.7	4.6	-2.1	-2.0	1.6
Epididymis fat weight	0.1	0.5	0.6	-0.8	-0.8	0.5
Delta time in closed arm before/after self-admin	4.4	4.2	4.5	-2.1	-2.1	1.9
Delta time in open arm before/after self-admin	0.0	0.0	0.0	0.0	0.0	0.1
Diff in mean of infusions in LGA sessions	0.1	0.2	0.3	-0.5	-0.3	-0.3
Delay discount exponential model param	0.2	0.3	0.5	-0.7	-0.6	0.3
Extinction: sum of active levers before priming	0.9	1.3	1.5	-1.1	-1.2	1.2
Active lever presses in extinction session 6	0.1	0.1	0.3	0.2	0.3	-0.6
Bone: final force	0.6	1.0	1.2	1.1	1.0	-0.8
Bone: final moment	0.4	0.7	0.9	1.0	0.8	-0.7
Food consumed during 24 hour testing period	0.5	1.1	1.1	-1.1	-1.1	1.0
Glucose	0.1	0.2	0.3	0.6	0.3	0.3
Heart weight	3.5	5.7	5.7	-2.4	-2.4	2.4
Delay discount hyperbolic model param	0.2	0.3	0.5	-0.7	-0.6	0.3
Intermittent access intake day 1-15 change	0.0	0.1	0.2	-0.4	-0.1	-0.4
Intermittent access intake escalation	0.0	0.1	0.2	-0.4	-0.1	-0.3
Intermittent access intake escalation 2	0.2	0.4	0.7	-0.8	-0.6	0.3
Intermitt. access day 1 inactive lever presses	0.1	1.8	3.1	0.9	1.2	-1.8
Intermitt. access day 15 inactive lever presses	0.4	2.2	2.4	1.4	1.5	-1.5
Intermitt. access escalation Index	0.6	1.9	2.1	-1.3	-1.5	1.4
Intermittent access day 1 total infusions	0.0	0.0	0.0	-0.0	0.1	-0.1
Intermittent access day 15 total infusions	0.0	0.1	0.2	-0.5	-0.2	-0.1
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.2	-0.0	0.2	-0.5
Intermittent access total infusions	0.0	0.1	0.1	-0.3	-0.1	-0.2
Intermittent access day 1 locomotion	0.0	0.1	0.1	0.3	0.3	-0.0
Intermittent access day 15 total locomotion	0.1	0.4	0.5	0.7	0.7	-0.5
Intermittent access total locomotion	0.9	1.0	1.2	1.1	1.1	-0.9
Intermittent access standard deviation	0.3	1.5	3.2	0.6	1.0	-1.8
Left kidney weight	0.4	3.0	4.2	-2.0	-1.8	1.2
Right kidney weight	0.0	0.2	0.3	-0.6	-0.4	-0.3
Cocaine induced anxiety	1.6	4.4	5.2	-2.3	-2.2	1.8
Post-drug Anxiety	0.9	1.1	1.3	-1.2	-1.1	0.8
Baseline Anxiety	1.6	2.7	3.6	1.9	1.7	-1.3
Tail length	0.6	3.2	4.6	-2.1	-1.8	1.3
Length with tail	3.3	14.7	19.7	-4.4	-4.0	2.9
Length without tail	2.0	10.7	12.1	-3.5	-3.4	2.9
Times rat made contact with spout	1.0	1.2	1.4	1.2	1.1	-1.0
Lifetime Intake	0.1	0.1	0.2	-0.2	0.1	-0.4
Liver weight, left	0.2	0.3	0.4	-0.6	-0.6	0.5
Liver weight, right	0.3	0.6	0.7	0.8	0.8	-0.6
Locomotor activity	0.5	0.8	1.1	0.8	0.8	-1.1
Locomotor testing distance	1.6	4.0	4.2	2.0	2.0	-2.0
Locomotor testing rearing	2.6	9.6	10.1	3.1	3.2	-2.9
Locomotion in novel chamber	4.9	6.5	7.3	2.7	2.7	-2.2
Locomotion in novel chamber post-restriction	0.1	0.3	0.4	0.5	0.6	-0.6
Fecal boli incidents, locomotor time 1	0.1	0.2	0.4	-0.4	-0.4	0.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.4	0.3	-0.3
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.6	0.7	0.6	-0.2
Bouts of movement, locomotor time 1	0.4	0.6	0.8	-0.9	-0.9	0.4
Total resting periods, locomotor time 1	0.9	1.0	1.3	-1.1	-1.1	0.6
Rest time, locomotor task time 1	0.0	0.0	0.0	-0.1	-0.1	-0.0
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.2	0.1	0.2
Vertical activity count, locomotor time 1	0.0	0.3	0.3	-0.5	-0.5	0.5
Time >=10cm from walls, locomotor time 2	0.5	1.4	1.6	1.3	1.2	-1.1
Bouts of movement, locomotor time 2	0.1	0.3	0.4	0.4	0.5	-0.7
Total resting periods, locomotor time 2	0.0	0.1	0.2	0.2	0.2	-0.5
Rest time, locomotor task time 2	0.6	1.0	1.2	-1.1	-1.1	0.8
Distance moved, locomotor task time 2	0.1	0.2	0.4	-0.1	-0.2	0.7
Vertical activity count, locomotor time 2	0.2	0.4	0.6	-0.5	-0.6	0.8
Light reinforcement 1	1.0	4.4	5.9	1.8	2.0	-2.4
Light reinforcement 2	0.4	0.8	1.0	0.8	0.9	-1.0
Bone: marrow area	2.0	4.8	5.2	-2.3	-2.3	2.0
Bone: maximum diameter	0.0	0.0	0.0	-0.1	0.0	-0.2
Bone: maximum force	0.0	0.0	0.1	-0.1	-0.2	0.3
Bone: maximum moment	0.1	0.1	0.2	-0.2	-0.3	0.5
Mean time between licks in bursts	0.4	2.6	2.6	-1.6	-1.6	1.6
Mean num. licks in bursts	0.0	0.1	0.1	0.3	0.3	-0.3
Cd content in liver	1.6	1.8	1.9	-1.4	-1.3	1.4
Co content in liver	1.9	2.2	2.5	-1.6	-1.5	1.4
Cu content in liver	0.1	0.1	0.2	-0.4	-0.2	-0.2
Fe content in liver	1.9	2.4	2.7	-1.6	-1.6	1.4
K content in liver	0.7	0.7	1.1	0.6	0.8	-1.0
Mg content in liver	0.6	0.6	0.7	0.8	0.8	-0.8
Mn content in liver	0.9	1.0	1.5	0.7	1.0	-1.2
Na content in liver	0.2	0.3	0.6	0.3	0.4	-0.8
Rb content in liver	1.7	1.9	2.2	1.5	1.5	-1.2
Se content in liver	6.8	8.0	9.4	2.6	2.8	-3.1
Sr content in liver	0.3	0.3	0.5	-0.7	-0.5	0.2
Zn content in liver	2.9	3.4	3.7	1.7	1.9	-1.9
Bone: minimum diameter	0.6	1.2	1.3	-1.1	-1.1	1.1
Time in familiar zone, hab. session 1	0.1	0.1	0.1	0.4	0.4	-0.1
Time in novel zone, hab. session 1	0.6	0.7	0.9	1.0	0.9	-0.6
Total zone transitions, hab. session 1	2.1	3.0	3.2	-1.8	-1.7	1.7
Total locomotion distance, hab. session 1	0.0	0.0	0.0	-0.1	-0.1	0.1
Locomotion velocity, hab. session 1	0.4	0.5	0.8	-0.9	-0.7	0.4
Time in familiar zone, hab. session 2	0.5	0.6	0.9	0.7	0.7	-1.0
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.3	0.3	-0.2
Total zone transitions, hab. session 2	1.0	1.3	1.3	-1.1	-1.1	1.1
Total locomotion distance, hab. session 2	0.2	0.2	0.3	-0.6	-0.6	0.3
Locomotion velocity, hab. session 2	0.4	0.6	0.7	-0.8	-0.8	0.6
Novel to familiar place preference ratio	1.0	1.3	1.4	-1.2	-1.2	1.0
Novelty place preference	0.7	0.9	1.0	-0.9	-1.0	1.0
Time in novel zone, NPP test	0.2	0.3	0.4	-0.5	-0.5	0.6
Total zone transitions, NPP test	0.4	0.6	0.7	-0.9	-0.9	0.6
Total locomotion distance, NPP test	0.0	0.0	0.0	-0.1	-0.1	-0.0
Locomotion velocity, NPP test	0.3	0.4	0.5	-0.7	-0.7	0.5
Intraocular pressure	2.4	4.0	5.0	-1.8	-1.9	2.2
Delta distance traveled before/after self-admin	1.2	1.3	1.6	-1.0	-1.1	1.3
Delta ambulatory time before/after self-admin	0.8	1.3	1.9	-0.9	-1.1	1.4
Parametrial fat weight	0.4	0.9	1.2	0.8	0.9	-1.1
Pavlov. Cond. lever latency	2.3	3.0	3.2	-1.8	-1.8	1.6
Pavlov. Cond. magazine entry latency	10.6	13.6	14.1	3.7	3.8	-3.6
Pavlov. Cond. change in total contacts	10.0	10.7	11.8	3.4	3.4	-2.9
Pavlov. Cond. index score	9.1	11.5	12.2	3.5	3.5	-3.2
Pavlov. Cond. latency score	7.0	8.8	9.5	3.1	3.0	-2.8
Pavlov. Cond. lever contacts	3.1	3.7	3.9	2.0	2.0	-1.8
Pavlov. Cond. magazine entry number	14.1	17.9	19.7	-4.4	-4.4	3.9
Pavlov. Cond. intertrial magazine entries	1.4	1.6	1.7	-1.3	-1.3	1.3
Pavlov. Cond. lever-magazine prob. diff.	10.9	13.5	14.2	3.8	3.8	-3.5
Pavlov. Cond. response bias	11.0	13.7	14.5	3.8	3.8	-3.5
Pavlov. Cond. lever latency	0.4	0.6	0.7	-0.7	-0.7	0.8
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.2	-0.2	0.1
Pavlov. Cond. change in total contacts	0.3	0.7	0.9	0.9	0.9	-0.7
Pavlov. Cond. index score	0.1	0.2	0.2	0.4	0.4	-0.4
Pavlov. Cond. latency score	0.1	0.1	0.1	0.4	0.3	-0.3
Pavlov. Cond. lever contacts	0.4	0.6	0.6	0.8	0.8	-0.8
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	-0.4	-0.3	0.2
Pavlov. Cond. intertrial magazine entries	1.0	2.1	2.2	-1.5	-1.5	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.1	0.3	0.3	-0.2
Pavlov. Cond. response bias	0.9	1.2	1.4	1.0	1.1	-1.2
Time in closed arm before self-admin	1.2	2.1	2.6	1.6	1.6	-1.1
Time in closed arm after self-admin	0.1	0.2	0.2	-0.4	-0.3	0.5
Time in open arm before self-admin	1.7	2.0	2.8	-1.7	-1.5	1.0
Time in open arm after self-admin	0.3	0.3	0.4	-0.6	-0.6	0.4
Bone: periosteal estimation	0.3	0.6	0.7	-0.8	-0.8	0.7
Bone: periosteal perimeter	0.7	1.5	1.7	-1.3	-1.3	1.0
Bone: post-yield work	1.1	1.9	2.4	-1.3	-1.4	1.5
Progressive ratio test 1 active lever presses	0.0	0.1	0.1	0.4	0.3	-0.1
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	0.3	0.2	-0.0
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.4	0.1	0.3	-0.6
Progressive ratio test 2 active lever presses	0.6	0.9	1.2	0.8	0.9	-1.1
Progressive ratio test 2 breakpoint	0.7	0.9	1.2	0.8	1.0	-1.1
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.4	-0.0	0.2	-0.6
Incentive Sensitization - Responses	0.6	1.8	2.4	1.1	1.3	-1.6
Incentive Sensitization - Breakpoint	0.7	1.6	2.2	1.0	1.2	-1.5
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	0.3	0.2	-0.2
Progressive ratio	0.0	0.1	0.2	-0.1	0.0	-0.4
Food seeking constrained by brief footshock	0.4	0.5	0.5	0.7	0.7	-0.7
Seeking ratio, punishment vs. effort	0.0	0.1	0.2	0.4	0.2	0.2
Retroperitoneal fat weight	0.0	0.2	0.2	0.5	0.5	-0.4
Reaction time number correct	0.4	1.4	1.5	-1.2	-1.2	1.1
Reaction time mean minus median	0.0	0.3	0.3	-0.4	-0.5	0.5
Reaction time mean minus median AUC	0.0	0.0	0.1	0.4	0.2	-0.0
Reaction time num false alarms	0.5	0.8	1.2	0.8	0.8	-1.1
Reaction time num false alarms AUC	0.3	0.6	1.0	0.6	0.7	-1.0
Reaction time trials correct on left	0.4	1.4	1.5	-1.2	-1.2	1.1
Reaction time trials on left	0.4	1.3	1.4	-1.2	-1.1	1.0
Reaction time mean	0.1	0.3	0.6	0.4	0.5	-0.7
Reaction time mean AUC	0.1	0.3	0.6	0.4	0.5	-0.7
Median of all reaction times	0.8	1.3	1.8	1.0	1.1	-1.4
Reaction time omissions	0.5	0.7	1.2	0.7	0.8	-1.1
Reaction time false alarm rate	1.2	1.7	2.1	1.2	1.2	-1.4
Reaction time premature initiation rate	0.3	0.5	0.9	0.4	0.6	-1.0
Reaction time premature initiations	0.0	0.1	0.2	-0.5	-0.4	-0.0
Std. dev. reaction times	0.0	0.0	0.0	0.1	0.1	-0.2
Reaction time trials completed	0.4	1.3	1.4	-1.2	-1.1	1.0
Reaction time trials AUC	0.3	1.2	1.2	-1.1	-1.1	1.0
Run reversals in cocaine runway, females	1.7	1.9	2.1	-1.3	-1.3	1.4
Run reversals in cocaine runway, males	0.2	0.3	0.4	0.6	0.6	-0.3
Latency to leave start box in cocaine runway	1.5	2.1	2.6	-1.6	-1.4	1.3
Latency to leave start box in cocaine runway, F	2.4	3.0	3.6	-1.9	-1.7	1.5
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	0.0	0.2	-0.2
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.4	-0.4	0.2
Total sessions with >9 infusions	0.1	0.1	0.1	0.1	0.2	-0.4
Short access day 1 total inactive lever presses	1.0	2.1	2.7	1.2	1.4	-1.6
Short access day 10 total inactive lever presses	0.0	0.2	0.4	-0.6	-0.3	-0.4
Short access day 1 total infusions	0.1	0.2	0.3	0.4	0.5	-0.5
Short access day 10 total infusions	0.2	0.4	0.5	0.5	0.6	-0.7
Short access total infusions	0.1	0.2	0.4	0.1	0.4	-0.6
Short access day 1 locomotion	0.7	1.2	1.3	1.0	1.1	-1.1
Short access day 10 total locomotion	0.7	2.8	3.2	1.8	1.7	-1.5
Short access total locomotion	0.2	0.3	0.4	0.5	0.6	-0.6
One hour access (0.3 mA shock)	0.2	0.3	0.3	-0.5	-0.5	0.5
Compulsive drug intake	0.1	0.1	0.4	0.1	-0.1	0.6
One hour access (shock baseline)	0.0	0.1	0.2	-0.4	-0.3	-0.1
Social response proportion	0.2	0.3	0.6	-0.2	-0.4	0.8
Social responses	0.0	0.0	0.1	0.2	0.2	0.0
Social time	0.0	0.0	0.0	-0.2	-0.2	0.0
Soleus weight	0.1	0.2	0.4	0.6	0.3	0.2
Bone: stiffness	0.0	0.0	0.0	-0.1	-0.1	0.1
Tibialis anterior weight	1.6	5.5	5.8	-2.3	-2.4	2.4
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	0.4	0.3	-0.1
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	0.1	0.1	-0.2
Time to tail flick, test, before self-admin	0.8	0.9	1.1	-0.9	-1.0	0.9
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.3	0.3	-0.2
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.5	0.5	0.5	-0.7
Delta time to tail flick, test, before/after SA	2.1	2.6	3.0	1.7	1.7	-1.4
Tibia length	1.4	4.0	4.7	-1.8	-2.0	2.2
Ambulatory time before self-admin	0.1	0.2	0.4	-0.6	-0.3	-0.2
Ambulatory time after self-admin	1.6	2.5	3.1	-1.8	-1.6	1.3
Bone: tissue strength	1.1	1.2	1.7	-0.9	-1.1	1.3
Total heroin consumption	2.1	2.4	4.0	1.1	1.4	-2.0
Bone: trabecular number	5.2	9.8	10.1	3.1	3.1	-3.2
Bone: trabecular spacing	1.7	2.5	2.7	-1.6	-1.6	1.6
Bone: trabecular thickness	0.1	0.1	0.2	0.3	0.3	-0.4
Bone: trabecular tissue density	0.0	0.0	0.1	0.0	-0.0	0.4
Water consumed over 24 hours	0.0	0.1	0.1	-0.2	-0.3	0.3
Number of responses in last shaping day	0.1	0.2	0.4	0.2	0.4	-0.6