Hub : Genes

Gpr4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Gpr4 0.06 0.06 1.2e-06 0.04 0.04 0.04 0.04 2.4e-05 4.4e-05 2.5e-05 2.5e-05
2 pVTA gene expression Gpr4 0.8 0.14 8.1e-06 0.03 0.03 0.02 0.03 9.8e-04 3.5e-03 1.1e-02 2.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.00.10.10.2-0.3
Area under the delay curve1.92.22.71.31.6
BMI with tail0.72.32.8-1.4-1.7
BMI without tail0.61.81.9-1.4-1.3
Body weight1.25.15.3-2.2-2.3
Weight adjusted by age0.00.00.0-0.1-0.0
Bone surface0.30.61.0-0.6-1.0
Bone volume0.20.40.7-0.4-0.8
Breakpoint value in progressive ratio session2.32.82.91.71.6
Number of licking bursts2.03.34.4-2.1-1.5
Context. condit. distance diff. score0.10.10.1-0.4-0.3
Locomotion velocity, session 10.00.10.10.20.2
Locomotion distance, session 10.00.10.1-0.2-0.3
Locomotion velocity, session 21.11.31.7-1.3-0.9
Locomotion distance, session 20.40.50.6-0.6-0.8
Locomotion velocity, session 30.20.20.3-0.5-0.3
Locomotion distance, session 30.80.91.00.91.0
Stereotopy head waving bouts, day 30.70.81.2-1.1-0.6
Stereotopy head waving duration, day 31.01.11.4-1.2-0.9
Locomotion velocity, session 70.10.10.20.40.2
Locomotion distance, session 70.00.00.1-0.2-0.2
Stereotopy head waving bouts, day 71.01.11.1-1.0-1.1
Stereotopy head waving duration, day 70.70.90.9-0.9-0.9
Locomotion velocity, session 80.00.00.1-0.10.2
Locomotion distance, session 80.00.00.1-0.1-0.3
Degree of sensitization distance0.60.60.6-0.8-0.8
Degree of sensitization stereotypy1.11.11.3-1.0-1.1
Conditioned locomotion0.00.00.00.20.1
Cocaine response after cond. corrected0.70.81.0-0.8-1.0
Cocaine response after cond. not corrected1.72.02.5-1.3-1.6
Cocaine response before conditioning1.61.92.1-1.5-1.3
Saline control response2.02.62.8-1.7-1.6
Bone: connectivity density0.00.10.10.3-0.2
Bone: cortical apparent density0.10.10.10.40.3
Bone: cortical area1.62.52.6-1.6-1.5
Bone: cortical porosity0.30.30.50.40.7
Bone: cortical porosity0.00.10.10.10.3
Bone: cortical thickness0.61.01.1-1.0-1.0
Bone: cortical thickness1.61.91.9-1.4-1.3
Bone: cortical tissue density0.20.20.20.50.4
Condit. Reinf. active minus inactive responses0.60.61.0-0.5-1.0
Condit. Reinf. active-inactive response ratio0.50.50.9-0.4-1.0
Condit. Reinf. active responses0.40.50.9-0.4-0.9
Condit. Reinf. inactive responses0.00.00.10.2-0.1
Incentive salience index mean0.30.40.6-0.4-0.8
Condit. Reinf. lever presses0.00.00.1-0.1-0.3
Condit. Reinf. active minus inactive responses0.10.10.2-0.3-0.4
Condit. Reinf. active-inactive response ratio0.50.60.8-0.6-0.9
Condit. Reinf. active responses0.10.10.10.30.3
Condit. Reinf. inactive responses0.60.80.90.81.0
Condit. Reinf. lever presses0.20.30.4-0.5-0.6
Condit. Reinf. lever reinforcers received0.10.10.10.30.3
Conditioned reinforcement - actives1.52.52.7-1.5-1.6
Conditioned reinforcement - inactives0.30.50.5-0.7-0.6
Conditioned locomotion2.53.33.4-1.8-1.8
Patch foraging indifference point 0 sec0.40.70.8-0.9-0.8
Patch foraging indifference point AUC2.63.84.6-2.1-1.7
Delay disc. indifference point, 0s delay1.41.61.71.21.3
Delay disc. indifference point, 16s delay1.31.41.61.11.2
Delay disc. indifference point, 2s delay4.24.75.71.92.4
Delay disc. indifference point, 24s delay0.10.10.1-0.3-0.3
Delay disc. indifference point, 4s delay0.00.00.0-0.00.2
Delay disc. indifference point, 8s delay1.82.12.41.41.6
Indifference point function ln k0.71.31.61.31.0
Indifference point function log k0.71.31.61.31.0
Patch foraging total patch changes 0 sec0.61.11.1-1.1-1.1
Patch foraging total patch changes 12 sec1.21.61.8-1.3-1.2
Patch foraging total patch changes 18 sec1.92.92.9-1.7-1.7
Patch foraging total patch changes 24 sec0.30.40.5-0.7-0.7
Patch foraging total patch changes 6 sec2.33.53.8-2.0-1.8
Patch foraging time to switch 0 sec2.95.96.32.42.5
Patch foraging water rate 0 sec3.16.56.6-2.6-2.5
Patch foraging water rate 12 sec0.10.30.4-0.5-0.6
Patch foraging water rate 18 sec0.10.20.2-0.4-0.4
Patch foraging water rate 24 sec0.71.01.0-1.0-1.0
Patch foraging water rate 6 sec0.81.11.2-1.0-1.1
Seeking ratio, delayed vs. immediate footshock1.82.22.51.61.4
Distance traveled before self-admin0.10.10.1-0.4-0.3
Distance traveled after self-admin0.10.10.10.40.4
Extensor digitorum longus weight1.66.56.7-2.5-2.6
Bone: elastic displacement1.11.21.51.21.0
Bone: elastic work0.00.00.0-0.1-0.2
Bone: endosteal estimation0.00.10.10.30.0
Bone: endosteal perimeter0.00.00.00.0-0.1
Epididymis fat weight0.20.70.80.80.9
Delta time in closed arm before/after self-admin0.00.00.00.20.1
Delta time in open arm before/after self-admin0.00.00.00.10.2
Diff in mean of infusions in LGA sessions1.51.81.81.31.4
Delay discount exponential model param1.51.62.0-1.1-1.4
Extinction: sum of active levers before priming0.10.10.10.30.2
Active lever presses in extinction session 60.00.00.0-0.2-0.2
Bone: final force0.40.60.7-0.8-0.8
Bone: final moment0.60.91.0-1.0-0.9
Food consumed during 24 hour testing period4.56.26.52.62.4
Glucose0.30.40.70.50.8
Heart weight2.23.33.7-1.9-1.7
Delay discount hyperbolic model param1.41.51.9-1.1-1.4
Intermittent access intake day 1-15 change0.10.20.2-0.4-0.4
Intermittent access intake escalation0.10.30.3-0.5-0.5
Intermittent access intake escalation 20.00.00.0-0.1-0.1
Intermitt. access day 1 inactive lever presses0.00.00.0-0.0-0.0
Intermitt. access day 15 inactive lever presses0.00.00.0-0.00.1
Intermitt. access escalation Index0.20.30.40.60.5
Intermittent access day 1 total infusions1.32.12.3-1.5-1.4
Intermittent access day 15 total infusions0.71.11.2-1.1-1.0
Intermittent access terminal intake (last 3 days)1.21.51.6-1.3-1.2
Intermittent access total infusions2.52.93.0-1.7-1.7
Intermittent access day 1 locomotion0.30.30.4-0.6-0.5
Intermittent access day 15 total locomotion0.10.20.3-0.5-0.3
Intermittent access total locomotion1.61.92.1-1.4-1.3
Intermittent access standard deviation0.10.20.30.40.5
Left kidney weight5.827.028.8-5.0-5.4
Right kidney weight5.324.325.1-4.8-5.0
Cocaine induced anxiety0.20.30.30.60.6
Post-drug Anxiety0.10.10.10.30.3
Baseline Anxiety0.00.00.0-0.0-0.0
Tail length0.31.11.4-1.2-0.9
Length with tail0.31.31.4-1.2-1.1
Length without tail0.41.41.9-1.0-1.4
Times rat made contact with spout0.00.00.00.2-0.2
Lifetime Intake2.22.72.9-1.7-1.6
Liver weight, left1.93.13.4-1.9-1.7
Liver weight, right1.32.22.5-1.4-1.6
Locomotor activity1.93.03.5-1.9-1.6
Locomotor testing distance1.01.82.1-1.4-1.2
Locomotor testing rearing4.18.38.8-3.0-2.8
Locomotion in novel chamber0.10.20.20.40.4
Locomotion in novel chamber post-restriction0.81.41.41.11.2
Fecal boli incidents, locomotor time 10.00.00.0-0.2-0.1
Change in fecal boli incidents, locomotor task0.90.91.10.81.0
Time >=10cm from walls, locomotor time 10.00.00.10.1-0.3
Bouts of movement, locomotor time 12.12.42.81.71.4
Total resting periods, locomotor time 12.93.23.51.91.7
Rest time, locomotor task time 10.10.20.30.50.3
Distance moved, locomotor task time 10.30.50.6-0.8-0.5
Vertical activity count, locomotor time 10.00.00.10.10.3
Time >=10cm from walls, locomotor time 20.10.10.20.20.5
Bouts of movement, locomotor time 24.36.87.32.72.5
Total resting periods, locomotor time 23.35.96.42.52.3
Rest time, locomotor task time 20.00.00.10.3-0.2
Distance moved, locomotor task time 20.60.71.1-1.0-0.6
Vertical activity count, locomotor time 20.20.30.50.30.7
Light reinforcement 10.10.10.2-0.2-0.5
Light reinforcement 20.00.10.1-0.2-0.3
Bone: marrow area0.00.00.10.3-0.0
Bone: maximum diameter2.34.44.6-2.0-2.2
Bone: maximum force0.20.30.4-0.6-0.5
Bone: maximum moment0.20.40.5-0.7-0.6
Mean time between licks in bursts0.10.10.20.30.4
Mean num. licks in bursts2.13.24.72.21.3
Cd content in liver0.00.10.10.3-0.1
Co content in liver1.31.51.51.21.2
Cu content in liver0.20.30.4-0.6-0.5
Fe content in liver4.35.26.6-2.6-1.9
K content in liver0.10.10.1-0.4-0.1
Mg content in liver0.40.40.6-0.8-0.5
Mn content in liver1.01.11.2-1.0-1.1
Na content in liver0.10.10.2-0.4-0.1
Rb content in liver0.20.20.4-0.2-0.6
Se content in liver3.03.64.8-2.2-1.5
Sr content in liver0.00.00.0-0.20.1
Zn content in liver0.70.80.9-0.9-0.9
Bone: minimum diameter0.20.30.3-0.5-0.5
Time in familiar zone, hab. session 10.20.20.2-0.5-0.3
Time in novel zone, hab. session 10.50.50.5-0.7-0.7
Total zone transitions, hab. session 10.20.30.4-0.4-0.6
Total locomotion distance, hab. session 10.40.60.70.70.8
Locomotion velocity, hab. session 11.31.92.01.31.4
Time in familiar zone, hab. session 20.20.20.3-0.5-0.2
Time in novel zone, hab. session 20.00.00.00.2-0.1
Total zone transitions, hab. session 20.40.50.7-0.8-0.6
Total locomotion distance, hab. session 20.60.80.90.81.0
Locomotion velocity, hab. session 20.40.50.70.60.8
Novel to familiar place preference ratio1.11.21.8-0.8-1.3
Novelty place preference1.01.11.6-0.8-1.3
Time in novel zone, NPP test1.21.31.8-0.9-1.3
Total zone transitions, NPP test0.10.20.3-0.6-0.3
Total locomotion distance, NPP test0.10.20.2-0.5-0.3
Locomotion velocity, NPP test0.10.10.2-0.4-0.3
Intraocular pressure0.00.00.00.0-0.1
Delta distance traveled before/after self-admin1.92.02.01.41.4
Delta ambulatory time before/after self-admin0.40.50.50.70.7
Parametrial fat weight0.00.10.1-0.2-0.4
Pavlov. Cond. lever latency0.60.81.10.71.0
Pavlov. Cond. magazine entry latency0.10.20.3-0.2-0.6
Pavlov. Cond. change in total contacts0.40.50.80.90.4
Pavlov. Cond. index score0.30.40.6-0.5-0.8
Pavlov. Cond. latency score0.10.10.2-0.2-0.5
Pavlov. Cond. lever contacts0.40.50.7-0.5-0.8
Pavlov. Cond. magazine entry number0.00.10.10.00.3
Pavlov. Cond. intertrial magazine entries0.10.10.1-0.4-0.4
Pavlov. Cond. lever-magazine prob. diff.0.40.50.7-0.5-0.8
Pavlov. Cond. response bias1.01.31.8-0.9-1.3
Pavlov. Cond. lever latency0.00.00.00.20.2
Pavlov. Cond. magazine entry latency0.20.30.6-0.0-0.8
Pavlov. Cond. change in total contacts0.10.10.30.50.1
Pavlov. Cond. index score0.00.10.10.2-0.3
Pavlov. Cond. latency score0.00.00.10.3-0.1
Pavlov. Cond. lever contacts0.10.10.2-0.3-0.4
Pavlov. Cond. magazine entry number0.20.20.4-0.7-0.0
Pavlov. Cond. intertrial magazine entries0.00.00.1-0.10.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.0-0.4
Pavlov. Cond. response bias0.00.10.10.1-0.3
Time in closed arm before self-admin0.91.21.3-1.1-1.0
Time in closed arm after self-admin0.70.70.80.80.9
Time in open arm before self-admin1.01.11.21.11.0
Time in open arm after self-admin0.20.20.20.50.4
Bone: periosteal estimation0.30.60.7-0.7-0.8
Bone: periosteal perimeter0.30.50.5-0.7-0.7
Bone: post-yield work0.60.91.01.00.9
Progressive ratio test 1 active lever presses2.53.13.3-1.8-1.7
Progressive ratio test 1 breakpoint2.22.72.9-1.7-1.6
Progressive ratio test 1 inactive lever presses1.11.61.8-1.4-1.2
Progressive ratio test 2 active lever presses2.12.42.5-1.6-1.5
Progressive ratio test 2 breakpoint2.42.72.8-1.7-1.6
Progressive ratio test 2 inactive lever presses0.10.10.2-0.4-0.3
Incentive Sensitization - Responses1.11.51.7-1.2-1.3
Incentive Sensitization - Breakpoint1.01.31.4-1.1-1.2
Sum of active levers in priming session hrs 5-60.30.30.30.50.6
Progressive ratio1.21.92.21.21.5
Food seeking constrained by brief footshock5.16.37.02.62.4
Seeking ratio, punishment vs. effort0.50.60.91.00.6
Retroperitoneal fat weight0.00.10.2-0.3-0.4
Reaction time number correct3.87.37.9-2.8-2.6
Reaction time mean minus median0.00.00.10.3-0.0
Reaction time mean minus median AUC0.20.40.7-0.4-0.8
Reaction time num false alarms4.15.86.1-2.3-2.5
Reaction time num false alarms AUC3.04.74.8-2.1-2.2
Reaction time trials correct on left3.87.37.9-2.8-2.6
Reaction time trials on left3.97.37.8-2.8-2.6
Reaction time mean0.91.42.01.40.9
Reaction time mean AUC0.71.11.61.30.8
Median of all reaction times1.41.92.51.61.2
Reaction time omissions0.10.10.2-0.1-0.5
Reaction time false alarm rate0.10.10.2-0.3-0.4
Reaction time premature initiation rate0.30.40.70.80.4
Reaction time premature initiations0.30.60.8-0.6-0.9
Std. dev. reaction times0.10.20.30.50.3
Reaction time trials completed3.97.37.8-2.8-2.6
Reaction time trials AUC4.78.99.4-3.1-2.9
Run reversals in cocaine runway, females0.30.30.40.50.6
Run reversals in cocaine runway, males0.50.50.5-0.7-0.7
Latency to leave start box in cocaine runway0.20.20.3-0.3-0.5
Latency to leave start box in cocaine runway, F0.91.01.1-1.0-1.0
Latency to leave start box in cocaine runway, M0.10.10.20.40.1
Std. dev. time between licks in bursts0.00.00.10.0-0.2
Total sessions with >9 infusions3.64.34.8-2.2-2.0
Short access day 1 total inactive lever presses0.40.50.5-0.7-0.7
Short access day 10 total inactive lever presses0.61.41.51.21.2
Short access day 1 total infusions1.82.42.5-1.6-1.5
Short access day 10 total infusions3.64.64.7-2.2-2.1
Short access total infusions2.02.52.8-1.7-1.5
Short access day 1 locomotion3.13.84.1-2.0-1.9
Short access day 10 total locomotion0.00.00.0-0.1-0.1
Short access total locomotion0.80.91.0-1.0-0.9
One hour access (0.3 mA shock)0.00.00.1-0.2-0.2
Compulsive drug intake0.40.50.6-0.6-0.8
One hour access (shock baseline)0.71.11.3-1.1-1.0
Social response proportion1.31.52.0-1.0-1.4
Social responses0.91.11.4-1.0-1.2
Social time3.04.04.32.12.0
Soleus weight0.10.40.5-0.5-0.7
Bone: stiffness0.71.21.4-1.2-1.0
Tibialis anterior weight3.210.911.7-3.2-3.4
Time to tail flick, vehicle, before self-admin2.72.83.0-1.7-1.6
Time to tail flick, vehicle, after self-admin0.00.00.0-0.1-0.1
Time to tail flick, test, before self-admin0.50.50.60.80.7
Time to tail flick, test, after self-admin0.30.30.40.50.6
Delta time to tail flick, vehicle, before/after SA0.10.10.10.30.3
Delta time to tail flick, test, before/after SA0.80.81.0-1.0-0.8
Tibia length0.30.91.0-0.9-1.0
Ambulatory time before self-admin0.00.00.00.00.0
Ambulatory time after self-admin0.40.50.50.70.7
Bone: tissue strength0.70.70.90.90.8
Total heroin consumption0.00.00.00.10.1
Bone: trabecular number0.00.10.20.4-0.0
Bone: trabecular spacing0.00.00.1-0.2-0.2
Bone: trabecular thickness1.41.82.0-1.3-1.4
Bone: trabecular tissue density0.30.50.6-0.8-0.7
Water consumed over 24 hours0.10.10.30.50.1
Number of responses in last shaping day3.03.33.5-1.9-1.8