Hub : Genes

Gpr4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Gpr4 0.06 0.06 1.2e-06 0.04 0.04 0.04 0.04 2.4e-05 4.4e-05 2.6e-05 2.3e-05
2 pVTA gene expression Gpr4 0.8 0.14 8.1e-06 0.03 0.03 0.02 0.03 9.8e-04 3.5e-03 1.1e-02 2.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.00.10.10.10.3
Area under the delay curve1.52.32.71.3-1.6
BMI with tail0.72.42.8-1.41.7
BMI without tail0.41.92.1-1.41.3
Body weight1.25.25.3-2.32.3
Weight adjusted by age0.00.00.0-0.10.0
Bone surface0.30.71.0-0.61.0
Bone volume0.20.40.7-0.40.8
Breakpoint value in progressive ratio session1.52.72.81.7-1.6
Number of licking bursts1.13.34.4-2.11.5
Context. condit. distance diff. score0.10.10.1-0.30.3
Locomotion velocity, session 10.10.10.10.3-0.2
Locomotion distance, session 10.00.00.1-0.10.3
Locomotion velocity, session 21.01.21.6-1.30.9
Locomotion distance, session 20.30.40.6-0.50.8
Locomotion velocity, session 30.10.20.3-0.50.3
Locomotion distance, session 30.80.91.00.9-1.0
Stereotopy head waving bouts, day 30.70.81.3-1.10.6
Stereotopy head waving duration, day 30.91.11.4-1.20.9
Locomotion velocity, session 70.10.10.20.4-0.2
Locomotion distance, session 70.00.00.1-0.20.2
Stereotopy head waving bouts, day 70.91.11.1-1.01.1
Stereotopy head waving duration, day 70.70.90.9-1.00.9
Locomotion velocity, session 80.00.00.10.0-0.2
Locomotion distance, session 80.00.00.10.00.3
Degree of sensitization distance0.60.60.6-0.80.8
Degree of sensitization stereotypy1.01.11.3-1.01.1
Conditioned locomotion0.00.00.00.2-0.1
Cocaine response after cond. corrected0.50.81.0-0.81.0
Cocaine response after cond. not corrected1.42.02.5-1.31.6
Cocaine response before conditioning1.61.92.0-1.41.3
Saline control response1.82.52.6-1.61.6
Bone: connectivity density0.00.10.10.30.2
Bone: cortical apparent density0.10.10.20.4-0.3
Bone: cortical area1.52.42.5-1.61.5
Bone: cortical porosity0.30.30.50.4-0.7
Bone: cortical porosity0.00.10.10.0-0.3
Bone: cortical thickness0.61.01.0-1.01.0
Bone: cortical thickness1.51.81.8-1.41.3
Bone: cortical tissue density0.10.20.30.5-0.4
Condit. Reinf. active minus inactive responses0.60.61.0-0.61.0
Condit. Reinf. active-inactive response ratio0.50.50.9-0.41.0
Condit. Reinf. active responses0.40.50.9-0.40.9
Condit. Reinf. inactive responses0.00.00.10.20.1
Incentive salience index mean0.30.40.6-0.40.8
Condit. Reinf. lever presses0.00.00.1-0.10.3
Condit. Reinf. active minus inactive responses0.10.20.2-0.30.4
Condit. Reinf. active-inactive response ratio0.40.60.8-0.60.9
Condit. Reinf. active responses0.00.10.10.2-0.3
Condit. Reinf. inactive responses0.60.90.90.9-1.0
Condit. Reinf. lever presses0.20.30.4-0.50.6
Condit. Reinf. lever reinforcers received0.10.10.10.3-0.3
Conditioned reinforcement - actives0.62.52.7-1.51.6
Conditioned reinforcement - inactives0.20.50.5-0.70.6
Conditioned locomotion2.23.33.4-1.81.8
Patch foraging indifference point 0 sec0.20.70.8-0.90.8
Patch foraging indifference point AUC1.63.84.6-2.21.7
Delay disc. indifference point, 0s delay1.41.61.71.2-1.3
Delay disc. indifference point, 16s delay1.01.41.61.1-1.2
Delay disc. indifference point, 2s delay4.14.65.71.9-2.4
Delay disc. indifference point, 24s delay0.00.10.1-0.20.3
Delay disc. indifference point, 4s delay0.00.00.0-0.0-0.2
Delay disc. indifference point, 8s delay1.32.12.41.4-1.6
Indifference point function ln k0.41.31.71.3-1.0
Indifference point function log k0.41.31.71.3-1.0
Patch foraging total patch changes 0 sec0.41.11.1-1.01.1
Patch foraging total patch changes 12 sec1.31.71.9-1.41.2
Patch foraging total patch changes 18 sec1.22.82.9-1.71.7
Patch foraging total patch changes 24 sec0.10.40.4-0.60.7
Patch foraging total patch changes 6 sec2.13.53.8-2.01.8
Patch foraging time to switch 0 sec1.55.76.32.3-2.5
Patch foraging water rate 0 sec1.66.26.4-2.42.5
Patch foraging water rate 12 sec0.10.30.4-0.40.6
Patch foraging water rate 18 sec0.10.10.2-0.30.4
Patch foraging water rate 24 sec0.60.80.9-0.91.0
Patch foraging water rate 6 sec0.71.01.2-0.91.1
Seeking ratio, delayed vs. immediate footshock1.62.32.51.6-1.4
Distance traveled before self-admin0.00.10.1-0.30.3
Distance traveled after self-admin0.10.10.20.4-0.4
Extensor digitorum longus weight1.66.56.7-2.52.6
Bone: elastic displacement1.01.31.71.3-1.0
Bone: elastic work0.00.00.0-0.00.2
Bone: endosteal estimation0.00.00.10.3-0.0
Bone: endosteal perimeter0.00.00.0-0.00.1
Epididymis fat weight0.20.80.80.8-0.9
Delta time in closed arm before/after self-admin0.10.00.10.3-0.1
Delta time in open arm before/after self-admin0.00.00.00.2-0.2
Diff in mean of infusions in LGA sessions1.01.81.81.3-1.4
Delay discount exponential model param1.21.62.0-1.11.4
Extinction: sum of active levers before priming0.00.10.10.3-0.2
Active lever presses in extinction session 60.00.00.0-0.20.2
Bone: final force0.40.60.7-0.80.8
Bone: final moment0.60.91.0-1.00.9
Food consumed during 24 hour testing period3.36.77.52.7-2.4
Glucose0.30.40.70.5-0.8
Heart weight2.13.43.7-1.91.7
Delay discount hyperbolic model param1.21.51.9-1.01.4
Intermittent access intake day 1-15 change0.00.20.2-0.40.4
Intermittent access intake escalation0.00.30.3-0.50.5
Intermittent access intake escalation 20.00.00.0-0.10.1
Intermitt. access day 1 inactive lever presses0.00.00.0-0.00.0
Intermitt. access day 15 inactive lever presses0.00.00.0-0.0-0.1
Intermitt. access escalation Index0.10.30.40.6-0.5
Intermittent access day 1 total infusions0.72.12.3-1.51.4
Intermittent access day 15 total infusions0.41.11.2-1.11.0
Intermittent access terminal intake (last 3 days)0.91.51.6-1.31.2
Intermittent access total infusions2.52.93.0-1.71.7
Intermittent access day 1 locomotion0.20.30.4-0.60.5
Intermittent access day 15 total locomotion0.00.20.3-0.50.3
Intermittent access total locomotion1.61.92.1-1.41.3
Intermittent access standard deviation0.00.20.30.4-0.5
Left kidney weight3.427.328.8-5.15.4
Right kidney weight3.524.225.1-4.85.0
Cocaine induced anxiety0.10.30.30.6-0.6
Post-drug Anxiety0.10.10.10.3-0.3
Baseline Anxiety0.00.00.0-0.00.0
Tail length0.21.01.3-1.20.9
Length with tail0.31.31.4-1.21.1
Length without tail0.31.41.9-1.01.4
Times rat made contact with spout0.00.00.00.20.2
Lifetime Intake2.22.72.9-1.71.6
Liver weight, left1.83.13.5-1.91.7
Liver weight, right1.32.22.5-1.41.6
Locomotor activity2.03.23.9-2.01.6
Locomotor testing distance0.81.92.3-1.51.2
Locomotor testing rearing2.38.48.9-3.02.8
Locomotion in novel chamber0.10.10.20.3-0.4
Locomotion in novel chamber post-restriction0.51.51.61.3-1.2
Fecal boli incidents, locomotor time 10.00.00.0-0.20.1
Change in fecal boli incidents, locomotor task0.90.91.10.9-1.0
Time >=10cm from walls, locomotor time 10.00.00.10.10.3
Bouts of movement, locomotor time 11.92.42.81.7-1.4
Total resting periods, locomotor time 12.83.23.51.9-1.7
Rest time, locomotor task time 10.10.20.20.5-0.3
Distance moved, locomotor task time 10.10.40.6-0.80.5
Vertical activity count, locomotor time 10.00.00.10.0-0.3
Time >=10cm from walls, locomotor time 20.00.10.20.2-0.5
Bouts of movement, locomotor time 22.06.87.22.7-2.5
Total resting periods, locomotor time 21.55.96.52.5-2.3
Rest time, locomotor task time 20.00.10.10.30.2
Distance moved, locomotor task time 20.50.71.0-1.00.6
Vertical activity count, locomotor time 20.10.30.50.2-0.7
Light reinforcement 10.00.10.2-0.20.5
Light reinforcement 20.00.10.1-0.30.3
Bone: marrow area0.00.00.10.20.0
Bone: maximum diameter2.24.44.6-2.12.2
Bone: maximum force0.20.30.4-0.60.5
Bone: maximum moment0.20.40.5-0.70.6
Mean time between licks in bursts0.00.10.20.3-0.4
Mean num. licks in bursts1.23.24.72.2-1.3
Cd content in liver0.00.10.10.30.1
Co content in liver1.31.51.51.2-1.2
Cu content in liver0.20.30.4-0.60.5
Fe content in liver4.25.26.6-2.61.9
K content in liver0.10.10.1-0.40.1
Mg content in liver0.40.40.6-0.80.5
Mn content in liver1.01.11.2-1.01.1
Na content in liver0.10.10.2-0.40.1
Rb content in liver0.20.20.4-0.20.6
Se content in liver3.03.64.8-2.21.5
Sr content in liver0.00.00.0-0.2-0.1
Zn content in liver0.70.80.9-0.90.9
Bone: minimum diameter0.10.30.3-0.50.5
Time in familiar zone, hab. session 10.20.20.2-0.50.3
Time in novel zone, hab. session 10.50.60.6-0.80.7
Total zone transitions, hab. session 10.20.30.4-0.40.6
Total locomotion distance, hab. session 10.40.60.70.7-0.8
Locomotion velocity, hab. session 11.31.92.01.3-1.4
Time in familiar zone, hab. session 20.10.20.3-0.50.2
Time in novel zone, hab. session 20.00.00.00.20.1
Total zone transitions, hab. session 20.40.50.7-0.80.6
Total locomotion distance, hab. session 20.60.80.90.8-1.0
Locomotion velocity, hab. session 20.40.50.70.7-0.8
Novel to familiar place preference ratio0.91.21.8-0.71.3
Novelty place preference0.81.01.6-0.71.3
Time in novel zone, NPP test1.01.21.8-0.81.3
Total zone transitions, NPP test0.10.10.2-0.40.3
Total locomotion distance, NPP test0.10.10.1-0.40.3
Locomotion velocity, NPP test0.10.10.1-0.30.3
Intraocular pressure0.00.00.00.10.1
Delta distance traveled before/after self-admin1.82.02.01.4-1.4
Delta ambulatory time before/after self-admin0.30.50.50.7-0.7
Parametrial fat weight0.10.10.1-0.40.4
Pavlov. Cond. lever latency0.60.81.10.7-1.0
Pavlov. Cond. magazine entry latency0.10.20.3-0.20.6
Pavlov. Cond. change in total contacts0.40.40.70.8-0.4
Pavlov. Cond. index score0.30.40.6-0.50.8
Pavlov. Cond. latency score0.10.10.2-0.20.5
Pavlov. Cond. lever contacts0.40.50.7-0.50.8
Pavlov. Cond. magazine entry number0.00.10.10.0-0.3
Pavlov. Cond. intertrial magazine entries0.10.10.1-0.30.4
Pavlov. Cond. lever-magazine prob. diff.0.40.50.7-0.50.8
Pavlov. Cond. response bias1.01.31.8-0.91.3
Pavlov. Cond. lever latency0.00.00.00.2-0.2
Pavlov. Cond. magazine entry latency0.20.30.6-0.10.8
Pavlov. Cond. change in total contacts0.00.10.20.4-0.1
Pavlov. Cond. index score0.00.00.10.10.3
Pavlov. Cond. latency score0.00.00.10.30.1
Pavlov. Cond. lever contacts0.10.20.2-0.40.4
Pavlov. Cond. magazine entry number0.10.20.4-0.60.0
Pavlov. Cond. intertrial magazine entries0.00.00.1-0.1-0.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.00.4
Pavlov. Cond. response bias0.00.10.1-0.00.3
Time in closed arm before self-admin0.61.11.1-1.01.0
Time in closed arm after self-admin0.70.80.80.9-0.9
Time in open arm before self-admin0.81.01.01.0-1.0
Time in open arm after self-admin0.20.20.20.4-0.4
Bone: periosteal estimation0.20.60.7-0.70.8
Bone: periosteal perimeter0.30.50.5-0.70.7
Bone: post-yield work0.50.91.01.0-0.9
Progressive ratio test 1 active lever presses1.83.13.3-1.81.7
Progressive ratio test 1 breakpoint1.62.72.9-1.71.6
Progressive ratio test 1 inactive lever presses0.61.61.8-1.41.2
Progressive ratio test 2 active lever presses1.72.42.5-1.61.5
Progressive ratio test 2 breakpoint2.12.72.8-1.71.6
Progressive ratio test 2 inactive lever presses0.00.10.2-0.40.3
Incentive Sensitization - Responses0.61.51.7-1.21.3
Incentive Sensitization - Breakpoint0.61.31.4-1.11.2
Sum of active levers in priming session hrs 5-60.30.30.30.5-0.6
Progressive ratio0.72.12.21.4-1.5
Food seeking constrained by brief footshock4.86.06.32.5-2.4
Seeking ratio, punishment vs. effort0.20.50.70.8-0.6
Retroperitoneal fat weight0.00.20.2-0.40.4
Reaction time number correct2.07.27.6-2.82.6
Reaction time mean minus median0.00.00.10.30.0
Reaction time mean minus median AUC0.10.40.7-0.40.8
Reaction time num false alarms3.45.86.1-2.42.5
Reaction time num false alarms AUC2.14.84.8-2.22.2
Reaction time trials correct on left2.07.27.6-2.82.6
Reaction time trials on left2.17.27.5-2.72.6
Reaction time mean0.61.41.91.4-0.9
Reaction time mean AUC0.51.11.51.2-0.8
Median of all reaction times1.21.92.41.5-1.2
Reaction time omissions0.10.10.20.00.5
Reaction time false alarm rate0.10.10.2-0.40.4
Reaction time premature initiation rate0.30.50.70.9-0.4
Reaction time premature initiations0.20.50.8-0.50.9
Std. dev. reaction times0.10.20.30.5-0.3
Reaction time trials completed2.17.27.5-2.72.6
Reaction time trials AUC2.58.79.1-3.02.9
Run reversals in cocaine runway, females0.20.30.40.4-0.6
Run reversals in cocaine runway, males0.50.50.5-0.70.7
Latency to leave start box in cocaine runway0.10.20.3-0.20.5
Latency to leave start box in cocaine runway, F0.70.91.1-0.91.0
Latency to leave start box in cocaine runway, M0.10.10.20.4-0.1
Std. dev. time between licks in bursts0.00.00.10.00.2
Total sessions with >9 infusions3.54.34.8-2.22.0
Short access day 1 total inactive lever presses0.30.50.5-0.70.7
Short access day 10 total inactive lever presses0.21.41.51.2-1.2
Short access day 1 total infusions1.22.42.5-1.61.5
Short access day 10 total infusions2.84.64.7-2.22.1
Short access total infusions1.82.52.8-1.71.5
Short access day 1 locomotion2.33.84.1-2.01.9
Short access day 10 total locomotion0.00.00.0-0.10.1
Short access total locomotion0.60.91.0-1.00.9
One hour access (0.3 mA shock)0.00.00.1-0.20.2
Compulsive drug intake0.30.50.6-0.60.8
One hour access (shock baseline)0.41.11.3-1.11.0
Social response proportion1.21.52.0-1.01.4
Social responses0.91.21.4-1.01.2
Social time2.64.04.22.1-2.0
Soleus weight0.10.40.5-0.50.7
Bone: stiffness0.71.21.5-1.21.0
Tibialis anterior weight3.211.011.7-3.23.4
Time to tail flick, vehicle, before self-admin2.32.93.1-1.81.6
Time to tail flick, vehicle, after self-admin0.00.00.0-0.10.1
Time to tail flick, test, before self-admin0.40.50.50.7-0.7
Time to tail flick, test, after self-admin0.30.30.40.4-0.6
Delta time to tail flick, vehicle, before/after SA0.10.10.10.3-0.3
Delta time to tail flick, test, before/after SA0.60.80.9-1.00.8
Tibia length0.30.81.0-0.81.0
Ambulatory time before self-admin0.00.00.00.0-0.0
Ambulatory time after self-admin0.30.50.50.7-0.7
Bone: tissue strength0.70.70.90.9-0.8
Total heroin consumption0.00.00.00.1-0.1
Bone: trabecular number0.00.10.10.40.0
Bone: trabecular spacing0.00.00.1-0.20.2
Bone: trabecular thickness1.31.82.0-1.31.4
Bone: trabecular tissue density0.30.50.6-0.70.7
Water consumed over 24 hours0.10.10.20.5-0.1
Number of responses in last shaping day2.53.33.5-1.91.8