Hub : Genes

Gosr1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Gosr1	0.02	0.01	8.6e-03	0.02	0.01	0.01	0.02	5.0e-03	1.0e-02	4.7e-02	7.1e-03
2	Liver	gene expression	Gosr1	0.04	0.04	1.6e-04	0.04	0.03	0.04	0.03	4.5e-05	2.6e-04	8.4e-05	1.1e-04
3	Adipose	gene expression	Gosr1	0.12	0.07	2.1e-15	0.12	0.1	0.11	0.11	4.2e-13	2.5e-11	3.8e-12	4.4e-12
4	NAcc	gene expression	Gosr1	0.01	0.01	3.0e-03	0.01	0.01	0.01	0.01	8.8e-03	3.7e-03	1.3e-02	1.1e-02
5	Brain	gene expression	Gosr1	0.02	0.02	4.5e-03	0.02	0.02	0.02	0.01	8.8e-03	9.1e-03	9.0e-03	1.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	2.1	3.8	4.4	1.8	1.9	1.8	-2.0	2.1
Area under the delay curve	1.0	1.6	3.2	-0.8	-1.8	-1.2	1.4	-0.9
BMI with tail	0.8	2.8	5.0	0.6	2.2	1.9	-1.8	1.3
BMI without tail	1.0	5.6	7.3	1.6	2.7	2.6	-2.5	2.3
Body weight	3.1	13.7	16.5	3.1	3.8	4.1	-3.8	3.7
Weight adjusted by age	0.0	0.0	0.1	-0.4	0.2	-0.2	-0.0	0.1
Bone surface	0.9	1.8	2.3	0.9	1.4	1.3	-1.5	1.5
Bone volume	1.0	2.0	2.6	1.0	1.5	1.3	-1.5	1.6
Breakpoint value in progressive ratio session	1.5	2.8	4.3	1.8	0.9	2.1	-1.6	1.7
Number of licking bursts	0.1	0.3	0.4	-0.5	-0.6	-0.6	0.5	-0.6
Context. condit. distance diff. score	0.9	1.1	1.6	1.3	1.1	0.7	-1.0	1.1
Locomotion velocity, session 1	2.2	2.5	4.1	1.5	0.8	1.6	-1.7	2.0
Locomotion distance, session 1	0.1	0.2	0.3	0.5	-0.4	0.5	-0.4	0.2
Locomotion velocity, session 2	0.2	0.2	0.5	0.7	-0.3	0.2	-0.3	0.7
Locomotion distance, session 2	0.7	1.0	1.3	1.1	0.6	1.2	-1.1	0.8
Locomotion velocity, session 3	1.7	2.0	2.5	-1.6	-1.3	-1.3	1.6	-1.2
Locomotion distance, session 3	0.4	0.5	1.1	-1.0	-0.3	-0.4	0.7	-0.7
Stereotopy head waving bouts, day 3	0.2	0.3	0.5	0.4	0.0	0.6	-0.5	0.7
Stereotopy head waving duration, day 3	0.3	0.3	0.7	-0.5	-0.8	-0.6	0.6	-0.4
Locomotion velocity, session 7	0.3	0.3	1.0	-0.4	1.0	0.4	-0.4	0.3
Locomotion distance, session 7	0.2	0.3	0.9	-0.1	0.9	0.3	-0.5	0.5
Stereotopy head waving bouts, day 7	0.8	0.9	1.5	0.7	0.8	1.0	-0.9	1.2
Stereotopy head waving duration, day 7	0.6	0.7	1.4	0.6	0.4	1.0	-0.8	1.2
Locomotion velocity, session 8	0.0	0.0	0.0	0.1	0.2	0.0	-0.1	0.1
Locomotion distance, session 8	1.0	1.5	2.3	1.4	0.8	1.0	-1.2	1.5
Degree of sensitization distance	2.0	2.2	2.9	1.5	1.7	1.2	-1.6	1.3
Degree of sensitization stereotypy	1.0	1.1	1.5	1.1	0.9	1.1	-1.0	1.2
Conditioned locomotion	0.5	0.6	1.2	-0.6	-1.1	-0.7	0.8	-0.5
Cocaine response after cond. corrected	1.1	1.6	2.3	1.4	0.9	1.5	-1.4	0.9
Cocaine response after cond. not corrected	1.4	2.1	3.1	1.5	1.1	1.8	-1.6	1.1
Cocaine response before conditioning	0.2	0.2	0.3	0.2	0.4	0.4	-0.5	0.5
Saline control response	0.2	0.3	0.8	-0.8	-0.1	-0.9	0.5	-0.3
Bone: connectivity density	3.3	5.2	5.9	2.1	2.4	2.4	-2.4	2.1
Bone: cortical apparent density	0.3	0.5	1.6	-0.4	-0.3	-0.3	0.6	-1.3
Bone: cortical area	1.7	2.8	4.6	-2.1	-1.2	-1.9	1.7	-1.1
Bone: cortical porosity	0.3	0.4	0.5	0.7	0.7	0.5	-0.5	0.4
Bone: cortical porosity	0.1	0.1	0.2	0.4	0.5	0.2	-0.2	0.1
Bone: cortical thickness	1.8	3.0	3.8	-1.9	-1.3	-1.9	2.0	-1.5
Bone: cortical thickness	0.1	0.1	0.3	-0.4	-0.4	-0.5	0.2	0.1
Bone: cortical tissue density	0.2	0.3	1.2	-0.2	-0.2	-0.1	0.4	-1.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.2	-0.5	0.3	0.2	0.3
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.2	-0.0	-0.0	0.2	0.1	0.4
Condit. Reinf. active responses	0.2	0.3	0.6	0.8	-0.0	0.6	-0.3	0.3
Condit. Reinf. inactive responses	0.2	0.2	0.5	0.7	0.3	0.2	-0.4	-0.5
Incentive salience index mean	0.2	0.2	0.4	0.6	-0.2	0.5	-0.1	0.7
Condit. Reinf. lever presses	0.8	1.3	2.3	1.1	0.9	1.1	-0.9	1.5
Condit. Reinf. active minus inactive responses	0.1	0.2	0.5	-0.2	-0.7	-0.3	0.2	0.3
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.8	-0.3	-0.9	-0.3	0.3	0.3
Condit. Reinf. active responses	0.1	0.2	0.3	-0.5	-0.3	-0.6	0.4	-0.1
Condit. Reinf. inactive responses	0.2	0.3	0.5	-0.6	0.7	-0.4	0.2	-0.6
Condit. Reinf. lever presses	2.0	2.9	4.3	-1.6	-2.1	-1.5	1.7	-1.5
Condit. Reinf. lever reinforcers received	0.2	0.3	0.5	-0.7	-0.6	-0.7	0.6	-0.3
Conditioned reinforcement - actives	0.0	0.2	0.3	0.4	0.5	0.3	-0.4	0.5
Conditioned reinforcement - inactives	0.0	0.1	0.2	-0.4	-0.1	-0.5	0.1	0.2
Conditioned locomotion	0.2	0.3	0.7	-0.8	0.2	-0.2	0.3	-0.8
Patch foraging indifference point 0 sec	0.0	0.1	0.2	-0.3	-0.5	-0.2	0.4	-0.0
Patch foraging indifference point AUC	1.1	2.6	3.9	-1.5	-2.0	-1.9	1.6	-0.9
Delay disc. indifference point, 0s delay	0.6	0.7	1.2	-0.5	-1.1	-1.1	0.8	0.6
Delay disc. indifference point, 16s delay	1.0	1.4	2.9	-0.6	-1.7	-1.2	1.2	-1.0
Delay disc. indifference point, 2s delay	1.6	1.8	3.3	-0.8	-1.8	-1.6	1.4	-0.7
Delay disc. indifference point, 24s delay	0.1	0.2	0.5	-0.3	0.7	-0.1	-0.2	-0.5
Delay disc. indifference point, 4s delay	0.2	0.2	0.6	0.4	-0.8	-0.1	0.2	-0.3
Delay disc. indifference point, 8s delay	0.3	0.5	1.1	-0.5	-1.0	-0.6	0.9	-0.6
Indifference point function ln k	0.5	1.6	2.2	1.5	1.3	1.4	-1.1	0.8
Indifference point function log k	0.5	1.6	2.2	1.5	1.3	1.4	-1.1	0.8
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	-0.4	-0.4	-0.3	0.4	-0.1
Patch foraging total patch changes 12 sec	0.4	0.6	0.9	-1.0	-0.6	-0.9	0.7	-0.5
Patch foraging total patch changes 18 sec	0.5	1.1	2.2	-0.7	-1.5	-1.2	1.0	-0.4
Patch foraging total patch changes 24 sec	0.5	1.8	3.8	-1.2	-2.0	-1.3	1.3	-0.8
Patch foraging total patch changes 6 sec	2.5	4.2	5.4	-2.1	-2.3	-2.3	2.1	-1.1
Patch foraging time to switch 0 sec	0.3	1.0	1.8	0.8	1.3	1.0	-1.2	0.4
Patch foraging water rate 0 sec	0.7	2.7	3.5	-1.6	-1.9	-1.8	1.7	-1.1
Patch foraging water rate 12 sec	0.0	0.1	0.5	0.1	0.7	-0.0	-0.2	-0.2
Patch foraging water rate 18 sec	0.3	0.6	1.3	1.1	0.9	0.5	-0.7	0.6
Patch foraging water rate 24 sec	0.4	0.6	1.1	-0.8	-0.5	-1.0	0.8	-0.7
Patch foraging water rate 6 sec	0.9	1.3	1.7	-1.0	-0.9	-1.3	1.3	-1.2
Seeking ratio, delayed vs. immediate footshock	2.1	2.9	4.0	-1.9	-1.3	-2.0	1.9	-1.4
Distance traveled before self-admin	2.0	4.3	5.7	-1.8	-2.4	-2.3	2.2	-1.7
Distance traveled after self-admin	0.0	0.1	0.1	-0.2	-0.3	-0.3	0.3	-0.2
Extensor digitorum longus weight	0.7	2.8	3.9	0.9	1.9	1.6	-1.7	2.0
Bone: elastic displacement	1.4	1.7	2.9	-0.8	-1.7	-1.3	1.4	-1.2
Bone: elastic work	4.0	5.2	7.0	-2.1	-2.6	-2.3	2.6	-1.5
Bone: endosteal estimation	0.4	0.9	1.8	-1.3	-1.0	-1.1	0.6	0.1
Bone: endosteal perimeter	0.2	0.5	1.0	-1.0	-0.5	-1.0	0.5	-0.3
Epididymis fat weight	5.0	25.4	27.3	5.1	5.2	4.8	-5.2	4.9
Delta time in closed arm before/after self-admin	1.5	1.4	2.1	-0.9	-1.2	-1.1	1.2	-1.5
Delta time in open arm before/after self-admin	2.1	2.5	4.1	1.0	2.0	1.8	-1.7	1.2
Diff in mean of infusions in LGA sessions	0.8	1.4	2.2	1.5	0.8	1.4	-1.2	0.9
Delay discount exponential model param	0.8	1.1	2.2	0.7	1.5	1.0	-1.1	0.7
Extinction: sum of active levers before priming	0.5	0.8	1.6	0.7	0.5	1.2	-1.1	0.5
Active lever presses in extinction session 6	0.7	0.7	0.9	0.8	0.4	0.9	-0.9	0.9
Bone: final force	0.4	0.6	1.8	-1.3	-0.4	-0.6	0.6	0.4
Bone: final moment	0.4	0.6	1.8	-1.3	-0.6	-0.6	0.7	0.3
Food consumed during 24 hour testing period	0.0	0.0	0.2	0.0	0.0	0.1	-0.0	0.5
Glucose	1.9	2.9	5.1	-1.5	-1.4	-1.6	1.7	-2.3
Heart weight	1.9	3.0	4.0	1.4	1.6	1.8	-1.8	2.0
Delay discount hyperbolic model param	1.0	1.3	2.8	0.7	1.7	1.1	-1.2	0.8
Intermittent access intake day 1-15 change	0.1	0.8	2.1	-1.1	-0.1	-0.5	0.5	-1.4
Intermittent access intake escalation	0.1	0.8	2.2	-1.2	0.0	-0.4	0.5	-1.5
Intermittent access intake escalation 2	0.8	1.4	2.2	-1.4	-0.8	-1.1	0.9	-1.5
Intermitt. access day 1 inactive lever presses	0.2	2.3	4.7	-2.2	-0.8	-1.0	1.2	-2.0
Intermitt. access day 15 inactive lever presses	0.5	2.9	4.9	-2.0	-1.0	-1.7	1.4	-2.2
Intermitt. access escalation Index	1.0	3.2	6.3	2.5	0.9	1.6	-1.6	1.9
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.1	0.1	-0.1	-0.0	-0.1
Intermittent access day 15 total infusions	0.1	0.2	0.5	-0.6	0.5	-0.2	-0.0	-0.7
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.4	-0.0	0.7	0.2	-0.4	-0.0
Intermittent access total infusions	0.2	0.2	0.5	-0.7	0.1	-0.5	0.2	-0.5
Intermittent access day 1 locomotion	0.1	0.3	0.6	-0.8	-0.2	-0.5	0.4	-0.4
Intermittent access day 15 total locomotion	0.2	0.6	2.1	-1.4	0.4	-0.2	0.1	-0.8
Intermittent access total locomotion	0.2	0.3	0.8	-0.9	0.3	-0.2	0.1	-0.6
Intermittent access standard deviation	0.3	1.8	3.1	-1.7	-0.5	-1.3	1.0	-1.7
Left kidney weight	0.0	0.3	0.7	0.2	0.8	0.8	-0.5	0.3
Right kidney weight	0.1	0.9	1.9	0.6	1.4	1.2	-0.8	0.6
Cocaine induced anxiety	0.0	0.1	0.2	0.3	-0.5	-0.2	0.3	-0.3
Post-drug Anxiety	1.3	1.5	3.0	1.7	0.7	1.4	-1.1	1.0
Baseline Anxiety	0.8	1.3	1.7	1.3	1.0	1.1	-1.1	1.2
Tail length	1.2	6.6	9.7	2.6	2.2	2.5	-2.4	3.1
Length with tail	1.8	8.1	10.6	3.0	2.5	2.8	-2.7	3.2
Length without tail	0.7	3.5	4.8	2.2	1.4	1.9	-1.7	2.0
Times rat made contact with spout	0.1	0.2	0.8	-0.9	0.2	0.1	0.0	0.0
Lifetime Intake	0.1	0.1	0.3	-0.6	0.2	-0.2	0.1	-0.5
Liver weight, left	6.5	11.2	15.2	3.2	3.1	3.2	-3.4	3.9
Liver weight, right	6.9	12.0	13.0	3.5	3.3	3.6	-3.4	3.5
Locomotor activity	0.1	0.2	0.8	0.1	-0.9	-0.1	0.1	0.3
Locomotor testing distance	0.1	0.3	1.0	-0.2	-1.0	-0.7	0.3	0.1
Locomotor testing rearing	0.1	0.2	0.4	-0.4	-0.6	-0.6	0.3	-0.4
Locomotion in novel chamber	3.5	4.7	6.5	-2.2	-1.7	-2.0	2.2	-2.6
Locomotion in novel chamber post-restriction	0.0	0.1	0.2	0.3	0.3	0.5	-0.1	-0.2
Fecal boli incidents, locomotor time 1	0.5	1.4	4.0	0.8	2.0	1.0	-1.1	0.5
Change in fecal boli incidents, locomotor task	0.1	0.2	0.4	-0.4	-0.6	-0.3	0.3	0.0
Time >=10cm from walls, locomotor time 1	0.2	0.3	1.3	-1.1	0.2	-0.0	0.2	0.0
Bouts of movement, locomotor time 1	0.3	0.4	0.8	-0.4	-0.9	-0.8	0.6	0.2
Total resting periods, locomotor time 1	0.2	0.2	0.6	-0.5	-0.4	-0.8	0.4	0.0
Rest time, locomotor task time 1	0.1	0.2	0.5	-0.5	0.4	-0.3	0.1	-0.7
Distance moved, locomotor task time 1	0.1	0.4	1.7	-0.0	-1.3	-0.0	0.3	0.1
Vertical activity count, locomotor time 1	0.0	0.2	0.3	0.4	-0.6	0.4	-0.0	0.5
Time >=10cm from walls, locomotor time 2	0.2	0.5	1.4	-0.9	1.2	0.2	-0.0	-0.3
Bouts of movement, locomotor time 2	0.1	0.2	0.5	0.2	-0.7	-0.5	0.3	-0.2
Total resting periods, locomotor time 2	0.0	0.1	0.2	0.3	-0.4	-0.1	-0.0	0.2
Rest time, locomotor task time 2	0.0	0.1	0.2	0.1	0.4	-0.1	-0.3	0.1
Distance moved, locomotor task time 2	0.4	0.5	1.2	-0.2	-1.1	-0.4	0.7	-0.8
Vertical activity count, locomotor time 2	0.1	0.3	0.9	-0.1	-0.9	-0.3	0.7	-0.4
Light reinforcement 1	0.0	0.0	0.2	0.2	-0.1	-0.0	0.1	-0.4
Light reinforcement 2	0.2	0.5	0.7	-0.7	-0.8	-0.5	0.7	-0.8
Bone: marrow area	0.4	0.9	1.8	-1.4	-1.0	-1.2	0.6	0.1
Bone: maximum diameter	1.1	2.1	4.1	-2.0	-1.0	-1.7	1.3	-0.9
Bone: maximum force	0.6	1.2	3.1	-1.8	-0.9	-1.1	1.0	0.1
Bone: maximum moment	0.7	1.4	3.1	-1.8	-1.1	-1.1	1.1	-0.1
Mean time between licks in bursts	0.2	1.0	1.2	1.0	1.0	0.9	-1.0	1.1
Mean num. licks in bursts	0.1	0.4	0.7	-0.1	0.8	0.7	-0.5	0.6
Cd content in liver	0.6	0.6	1.2	-0.2	-1.1	-1.1	0.7	-0.4
Co content in liver	0.2	0.3	0.4	-0.6	-0.7	-0.5	0.5	-0.2
Cu content in liver	1.3	1.5	2.1	-1.1	-1.4	-1.5	1.3	-0.8
Fe content in liver	1.0	1.3	1.6	1.2	1.2	1.0	-1.3	0.9
K content in liver	0.5	0.5	1.0	0.2	0.4	0.9	-0.6	1.0
Mg content in liver	0.3	0.3	0.5	-0.7	-0.5	-0.5	0.6	0.0
Mn content in liver	0.1	0.2	0.3	-0.4	-0.5	-0.3	0.4	-0.3
Na content in liver	0.1	0.1	0.3	-0.2	-0.2	-0.3	0.3	-0.5
Rb content in liver	0.1	0.1	0.3	0.0	0.1	-0.1	-0.2	0.6
Se content in liver	0.5	0.6	1.6	-0.4	-1.3	-0.7	0.7	-0.3
Sr content in liver	0.2	0.1	0.3	0.3	0.6	0.3	-0.4	0.2
Zn content in liver	0.4	0.4	0.7	0.6	0.6	0.5	-0.7	0.9
Bone: minimum diameter	0.3	0.6	1.3	-1.1	-0.6	-1.0	0.6	-0.2
Time in familiar zone, hab. session 1	0.4	0.4	0.7	-0.9	-0.3	-0.7	0.7	-0.7
Time in novel zone, hab. session 1	0.1	0.1	0.4	0.6	-0.2	0.3	-0.4	0.2
Total zone transitions, hab. session 1	0.1	0.2	0.3	0.2	-0.6	-0.3	0.3	-0.6
Total locomotion distance, hab. session 1	0.1	0.2	0.8	0.9	-0.0	0.1	-0.1	0.1
Locomotion velocity, hab. session 1	0.1	0.1	0.4	0.6	-0.3	-0.2	0.2	-0.0
Time in familiar zone, hab. session 2	0.0	0.0	0.1	-0.0	-0.2	-0.3	0.1	0.3
Time in novel zone, hab. session 2	0.3	0.4	0.9	-0.5	-0.6	-0.3	0.5	-0.9
Total zone transitions, hab. session 2	0.5	0.7	1.6	1.3	0.3	0.9	-0.8	0.4
Total locomotion distance, hab. session 2	0.3	0.4	1.3	1.2	-0.1	0.7	-0.4	0.2
Locomotion velocity, hab. session 2	0.2	0.3	1.1	1.1	-0.2	0.6	-0.3	0.1
Novel to familiar place preference ratio	0.1	0.2	0.5	-0.4	0.3	0.0	-0.1	-0.7
Novelty place preference	0.1	0.1	0.3	-0.1	0.5	0.3	-0.3	-0.3
Time in novel zone, NPP test	0.1	0.2	0.4	0.2	0.6	0.4	-0.5	-0.2
Total zone transitions, NPP test	0.1	0.1	0.3	0.5	-0.5	0.3	-0.2	-0.0
Total locomotion distance, NPP test	0.4	0.6	1.8	0.3	-1.3	-0.5	0.6	-0.7
Locomotion velocity, NPP test	0.7	0.9	2.3	-0.1	-1.5	-0.8	0.9	-1.0
Intraocular pressure	1.4	2.3	2.8	-1.4	-1.4	-1.7	1.5	-1.7
Delta distance traveled before/after self-admin	2.6	2.8	3.4	1.4	1.9	1.8	-1.8	1.5
Delta ambulatory time before/after self-admin	1.4	2.4	3.0	1.4	1.7	1.6	-1.6	1.4
Parametrial fat weight	7.2	16.9	18.5	4.2	4.0	4.0	-4.3	4.0
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.4	-0.0	-0.3	0.1	-0.5
Pavlov. Cond. magazine entry latency	0.6	0.7	1.3	0.8	0.4	1.0	-0.7	1.1
Pavlov. Cond. change in total contacts	0.2	0.2	0.3	-0.4	-0.4	-0.4	0.6	-0.6
Pavlov. Cond. index score	0.3	0.4	1.1	0.5	0.1	0.7	-0.4	1.0
Pavlov. Cond. latency score	0.5	0.6	1.4	0.7	0.3	0.9	-0.5	1.2
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.4	0.1	0.4	-0.1	0.4
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	-0.4	0.1	-0.5	0.2	-0.6
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.8	-0.1	-0.6	-0.6	0.5	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.8	0.4	-0.0	0.6	-0.3	0.9
Pavlov. Cond. response bias	0.3	0.4	0.7	0.7	0.1	0.7	-0.4	0.8
Pavlov. Cond. lever latency	2.4	3.3	5.9	1.6	2.4	1.7	-1.8	1.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.1	-0.4	0.5	0.1	-0.5
Pavlov. Cond. change in total contacts	1.0	2.3	3.7	-1.7	-1.9	-1.4	1.5	-1.0
Pavlov. Cond. index score	1.8	2.8	4.6	-1.5	-2.1	-1.4	1.6	-1.6
Pavlov. Cond. latency score	2.0	3.3	5.1	-1.6	-2.3	-1.5	1.8	-1.8
Pavlov. Cond. lever contacts	1.2	1.7	3.8	-1.1	-1.9	-1.1	1.2	-1.0
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	0.4	0.6	-0.3	-0.2	0.6
Pavlov. Cond. intertrial magazine entries	0.4	0.8	1.3	1.0	1.2	0.2	-0.8	1.0
Pavlov. Cond. lever-magazine prob. diff.	1.5	2.4	3.8	-1.4	-2.0	-1.2	1.5	-1.6
Pavlov. Cond. response bias	0.9	1.3	2.8	-0.9	-1.7	-0.9	1.1	-1.0
Time in closed arm before self-admin	1.1	1.9	4.3	1.4	1.0	0.9	-1.3	2.1
Time in closed arm after self-admin	0.7	0.8	1.7	-0.6	-0.9	-1.3	1.0	-0.5
Time in open arm before self-admin	2.0	2.5	4.4	-1.6	-1.2	-1.4	1.5	-2.1
Time in open arm after self-admin	0.4	0.5	1.1	-0.5	0.8	0.6	-0.2	-1.0
Bone: periosteal estimation	0.9	2.2	4.4	-2.1	-1.3	-1.8	1.3	-0.4
Bone: periosteal perimeter	0.7	1.5	2.6	-1.6	-0.9	-1.4	1.1	-0.8
Bone: post-yield work	0.3	0.6	1.0	0.4	0.9	0.6	-0.7	1.0
Progressive ratio test 1 active lever presses	0.4	0.7	0.9	-0.9	-0.8	-0.9	0.9	-0.6
Progressive ratio test 1 breakpoint	0.4	0.8	0.9	-1.0	-0.9	-0.9	0.9	-0.6
Progressive ratio test 1 inactive lever presses	1.9	4.9	7.3	-2.7	-1.9	-2.2	2.2	-1.9
Progressive ratio test 2 active lever presses	0.8	1.1	2.2	-1.5	-0.8	-1.2	0.9	-0.7
Progressive ratio test 2 breakpoint	0.8	1.0	2.1	-1.4	-0.8	-1.1	0.9	-0.6
Progressive ratio test 2 inactive lever presses	0.6	1.8	4.0	-2.0	-0.6	-1.2	1.1	-1.4
Incentive Sensitization - Responses	0.0	0.1	0.4	-0.6	-0.0	-0.3	0.2	-0.3
Incentive Sensitization - Breakpoint	0.0	0.1	0.3	-0.5	0.0	-0.3	0.1	-0.2
Sum of active levers in priming session hrs 5-6	3.0	2.9	4.2	1.5	1.1	2.0	-1.7	1.9
Progressive ratio	0.1	0.2	0.3	-0.6	0.3	-0.3	0.3	-0.5
Food seeking constrained by brief footshock	0.2	0.2	0.8	0.5	0.9	0.2	-0.2	-0.1
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.2	-0.3	-0.2	0.1	-0.1
Retroperitoneal fat weight	0.4	2.0	3.6	1.9	1.5	1.2	-1.4	0.8
Reaction time number correct	0.1	0.3	0.4	0.7	0.6	0.5	-0.6	0.3
Reaction time mean minus median	0.1	0.5	1.1	1.0	0.5	0.7	-0.5	-0.6
Reaction time mean minus median AUC	0.2	1.4	2.2	1.5	1.4	1.3	-1.2	-0.1
Reaction time num false alarms	2.6	4.5	6.5	-2.2	-2.6	-2.1	2.3	-1.1
Reaction time num false alarms AUC	2.1	4.7	6.5	-2.4	-2.5	-2.1	2.4	-1.1
Reaction time trials correct on left	0.1	0.3	0.4	0.7	0.6	0.5	-0.6	0.3
Reaction time trials on left	0.1	0.3	0.5	0.7	0.6	0.5	-0.6	0.2
Reaction time mean	0.3	0.6	1.0	1.0	0.7	0.8	-0.8	-0.3
Reaction time mean AUC	0.2	0.4	0.6	0.8	0.5	0.6	-0.6	-0.7
Median of all reaction times	0.2	0.3	0.4	0.7	0.4	0.5	-0.6	-0.2
Reaction time omissions	1.1	1.8	2.9	1.7	1.4	1.7	-1.2	0.2
Reaction time false alarm rate	3.1	4.2	6.1	-2.3	-2.5	-2.0	2.3	-0.9
Reaction time premature initiation rate	0.1	0.1	0.3	0.5	-0.1	0.4	-0.4	0.3
Reaction time premature initiations	0.1	0.2	0.6	0.8	0.1	0.5	-0.5	0.2
Std. dev. reaction times	0.2	0.7	1.1	1.1	0.8	1.0	-0.7	-0.6
Reaction time trials completed	0.1	0.3	0.5	0.7	0.6	0.5	-0.6	0.2
Reaction time trials AUC	0.1	0.2	0.3	0.5	0.5	0.5	-0.5	0.2
Run reversals in cocaine runway, females	0.2	0.3	1.2	0.1	0.1	0.4	-0.1	-1.1
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.5	0.2	0.3	-0.2	0.2
Latency to leave start box in cocaine runway	0.0	0.0	0.1	-0.1	0.4	-0.0	0.0	0.3
Latency to leave start box in cocaine runway, F	0.3	0.4	0.5	0.6	0.7	0.5	-0.4	0.6
Latency to leave start box in cocaine runway, M	0.2	0.2	0.6	-0.8	-0.1	-0.6	0.4	-0.0
Std. dev. time between licks in bursts	0.1	0.2	0.4	-0.6	-0.1	-0.6	0.2	0.1
Total sessions with >9 infusions	0.1	0.1	0.4	-0.3	0.1	0.0	0.1	-0.7
Short access day 1 total inactive lever presses	0.5	1.1	2.6	0.3	1.6	1.2	-1.1	0.2
Short access day 10 total inactive lever presses	0.2	1.4	4.1	-2.0	-0.5	-0.9	0.9	-1.1
Short access day 1 total infusions	0.3	0.6	1.9	-0.8	0.1	-0.4	0.4	-1.4
Short access day 10 total infusions	0.1	0.2	0.9	-0.3	0.1	0.2	-0.0	-1.0
Short access total infusions	0.4	0.6	1.6	-0.9	-0.3	-0.5	0.5	-1.3
Short access day 1 locomotion	0.9	1.5	3.8	-1.4	-0.5	-0.6	1.0	-1.9
Short access day 10 total locomotion	0.5	2.1	3.3	-1.8	-1.4	-1.2	1.3	-1.4
Short access total locomotion	1.9	2.8	4.2	-2.0	-1.4	-1.4	1.5	-2.0
One hour access (0.3 mA shock)	0.0	0.0	0.2	-0.4	-0.1	-0.1	0.2	-0.0
Compulsive drug intake	1.5	2.2	3.5	1.6	1.1	1.9	-1.4	1.3
One hour access (shock baseline)	0.3	0.8	1.6	-1.2	-0.4	-1.1	0.8	-0.6
Social response proportion	4.0	5.1	5.5	2.2	2.4	2.3	-2.0	2.4
Social responses	1.9	2.4	3.1	1.8	1.6	1.5	-1.5	1.5
Social time	1.8	2.8	3.6	1.7	1.7	1.5	-1.6	1.9
Soleus weight	3.5	10.4	14.0	2.7	3.0	3.4	-3.2	3.7
Bone: stiffness	0.7	1.4	2.9	0.2	1.2	0.9	-1.2	1.7
Tibialis anterior weight	2.5	8.4	9.4	2.4	3.0	3.0	-3.1	3.0
Time to tail flick, vehicle, before self-admin	0.5	0.6	2.6	0.4	-0.1	0.2	-0.5	1.6
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.5	0.2	-0.7	-0.1	0.2	-0.1
Time to tail flick, test, before self-admin	0.3	0.3	1.2	0.5	0.2	0.2	-0.3	1.1
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.0	-0.1	-0.0	0.1	-0.1
Delta time to tail flick, vehicle, before/after SA	0.3	0.4	1.6	-0.1	-0.1	-0.1	0.4	-1.3
Delta time to tail flick, test, before/after SA	0.6	0.7	1.2	-1.0	-0.6	-0.6	0.7	-1.1
Tibia length	0.3	0.8	1.8	0.6	0.6	1.1	-0.6	1.3
Ambulatory time before self-admin	0.9	2.6	4.1	-1.3	-2.0	-1.6	1.7	-1.3
Ambulatory time after self-admin	0.1	0.2	0.6	0.4	-0.1	0.5	-0.3	0.7
Bone: tissue strength	0.5	0.5	0.9	-0.9	-0.4	-0.3	1.0	-0.6
Total heroin consumption	5.2	6.1	7.8	2.3	2.3	2.8	-2.6	2.3
Bone: trabecular number	2.6	4.9	5.8	2.4	2.1	2.2	-2.4	2.0
Bone: trabecular spacing	0.4	0.6	1.3	-1.1	-0.0	-0.6	0.8	-0.9
Bone: trabecular thickness	0.1	0.1	0.4	-0.3	-0.3	-0.3	-0.0	0.6
Bone: trabecular tissue density	1.1	2.0	2.7	-1.1	-1.7	-1.5	1.4	-1.3
Water consumed over 24 hours	0.0	0.1	0.2	0.0	-0.0	0.4	-0.2	0.5
Number of responses in last shaping day	1.8	2.3	3.7	-1.9	-1.0	-1.2	1.4	-1.8