Gna13

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Gna13 0.04 0.03 3.3e-03 0 0.01 -0 0 1.0e-01 3.4e-02 5.9e-01 1.9e-01
2 Adipose gene expression Gna13 0.21 0.08 0.0e+00 0.13 0.16 0.14 0.15 1.9e-14 7.3e-18 2.0e-15 3.5e-16

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density3.66.710.3-1.83.2
Area under the delay curve0.00.00.1-0.30.0
BMI with tail1.34.69.1-0.3-3.0
BMI without tail1.15.610.5-0.9-3.2
Body weight1.46.17.0-2.6-2.3
Weight adjusted by age1.23.45.90.9-2.4
Bone surface7.514.818.3-3.34.3
Bone volume7.114.216.6-3.44.1
Breakpoint value in progressive ratio session1.83.33.71.7-1.9
Number of licking bursts0.00.10.2-0.50.1
Context. condit. distance diff. score0.00.00.0-0.2-0.2
Locomotion velocity, session 10.00.00.0-0.1-0.0
Locomotion distance, session 10.00.00.1-0.3-0.1
Locomotion velocity, session 20.10.10.2-0.10.4
Locomotion distance, session 20.00.00.00.20.0
Locomotion velocity, session 31.41.72.50.9-1.6
Locomotion distance, session 30.10.10.2-0.40.2
Stereotopy head waving bouts, day 34.45.28.12.8-1.5
Stereotopy head waving duration, day 32.12.64.02.0-1.1
Locomotion velocity, session 70.00.00.0-0.00.1
Locomotion distance, session 71.51.92.3-1.51.2
Stereotopy head waving bouts, day 71.01.22.11.5-0.5
Stereotopy head waving duration, day 72.02.54.42.1-0.8
Locomotion velocity, session 80.00.00.00.1-0.2
Locomotion distance, session 80.10.20.3-0.50.2
Degree of sensitization distance0.60.60.6-0.80.8
Degree of sensitization stereotypy0.40.50.70.8-0.5
Conditioned locomotion0.60.70.9-0.71.0
Cocaine response after cond. corrected0.60.90.9-1.00.9
Cocaine response after cond. not corrected1.01.41.4-1.21.2
Cocaine response before conditioning0.00.00.0-0.10.1
Saline control response1.41.93.80.1-1.9
Bone: connectivity density2.94.68.3-1.02.9
Bone: cortical apparent density4.06.37.62.7-2.3
Bone: cortical area0.91.42.3-1.50.7
Bone: cortical porosity5.86.36.8-2.62.4
Bone: cortical porosity4.24.66.3-2.51.7
Bone: cortical thickness5.59.111.72.6-3.4
Bone: cortical thickness2.42.93.51.9-1.5
Bone: cortical tissue density4.06.37.52.7-2.2
Condit. Reinf. active minus inactive responses2.22.54.0-2.01.0
Condit. Reinf. active-inactive response ratio0.60.60.7-0.80.8
Condit. Reinf. active responses2.83.55.3-2.31.4
Condit. Reinf. inactive responses1.11.52.1-1.40.9
Incentive salience index mean1.11.42.0-1.40.8
Condit. Reinf. lever presses0.00.00.10.1-0.2
Condit. Reinf. active minus inactive responses6.49.811.2-3.32.9
Condit. Reinf. active-inactive response ratio4.87.78.1-2.82.7
Condit. Reinf. active responses8.612.315.0-3.93.1
Condit. Reinf. inactive responses1.01.52.3-1.50.9
Condit. Reinf. lever presses3.14.66.2-2.51.7
Condit. Reinf. lever reinforcers received7.911.113.7-3.72.9
Conditioned reinforcement - actives0.31.01.4-0.71.2
Conditioned reinforcement - inactives0.10.20.4-0.60.2
Conditioned locomotion1.72.53.8-2.01.1
Patch foraging indifference point 0 sec1.13.26.3-2.50.3
Patch foraging indifference point AUC0.10.20.2-0.5-0.5
Delay disc. indifference point, 0s delay0.00.00.00.20.1
Delay disc. indifference point, 16s delay0.10.10.1-0.4-0.2
Delay disc. indifference point, 2s delay0.10.10.2-0.40.3
Delay disc. indifference point, 24s delay0.91.52.0-1.41.0
Delay disc. indifference point, 4s delay0.00.00.00.2-0.1
Delay disc. indifference point, 8s delay0.81.41.41.2-1.2
Indifference point function ln k0.10.20.5-0.20.7
Indifference point function log k0.10.20.5-0.20.7
Patch foraging total patch changes 0 sec0.92.55.0-2.20.1
Patch foraging total patch changes 12 sec1.92.64.6-2.20.8
Patch foraging total patch changes 18 sec0.41.01.6-0.7-1.2
Patch foraging total patch changes 24 sec0.72.54.6-2.20.6
Patch foraging total patch changes 6 sec2.34.07.9-2.80.1
Patch foraging time to switch 0 sec0.00.10.20.4-0.1
Patch foraging water rate 0 sec0.41.42.5-1.60.5
Patch foraging water rate 12 sec0.20.91.70.3-1.3
Patch foraging water rate 18 sec0.00.10.10.10.4
Patch foraging water rate 24 sec0.00.00.10.10.3
Patch foraging water rate 6 sec0.20.30.30.6-0.6
Seeking ratio, delayed vs. immediate footshock0.30.50.9-0.1-1.0
Distance traveled before self-admin0.81.71.81.2-1.3
Distance traveled after self-admin0.10.10.20.2-0.4
Extensor digitorum longus weight1.97.610.82.1-3.3
Bone: elastic displacement0.70.80.90.9-0.9
Bone: elastic work0.10.10.2-0.1-0.4
Bone: endosteal estimation15.738.542.8-6.55.8
Bone: endosteal perimeter16.841.146.6-6.86.0
Epididymis fat weight0.94.69.10.5-3.0
Delta time in closed arm before/after self-admin0.80.71.4-0.11.2
Delta time in open arm before/after self-admin0.60.70.91.0-0.7
Diff in mean of infusions in LGA sessions1.42.42.41.6-1.6
Delay discount exponential model param0.20.20.40.6-0.3
Extinction: sum of active levers before priming0.10.10.1-0.2-0.3
Active lever presses in extinction session 60.10.10.1-0.20.3
Bone: final force0.91.41.4-1.21.2
Bone: final moment0.91.51.6-1.21.3
Food consumed during 24 hour testing period1.93.95.91.4-2.4
Glucose0.30.40.70.3-0.9
Heart weight0.91.52.7-1.70.5
Delay discount hyperbolic model param0.10.20.30.5-0.2
Intermittent access intake day 1-15 change0.21.11.4-1.20.9
Intermittent access intake escalation0.21.01.4-1.20.7
Intermittent access intake escalation 21.22.02.2-1.51.3
Intermitt. access day 1 inactive lever presses0.00.40.7-0.80.1
Intermitt. access day 15 inactive lever presses0.00.10.20.1-0.4
Intermitt. access escalation Index0.00.00.00.2-0.1
Intermittent access day 1 total infusions0.00.10.2-0.40.0
Intermittent access day 15 total infusions0.51.11.9-1.40.6
Intermittent access terminal intake (last 3 days)1.42.43.1-1.81.3
Intermittent access total infusions0.81.01.4-1.20.7
Intermittent access day 1 locomotion0.61.22.1-1.50.4
Intermittent access day 15 total locomotion0.72.64.0-2.01.1
Intermittent access total locomotion2.53.05.4-2.30.7
Intermittent access standard deviation0.20.91.4-1.20.7
Left kidney weight0.00.30.6-0.4-0.7
Right kidney weight0.00.30.4-0.4-0.6
Cocaine induced anxiety0.30.71.4-0.31.2
Post-drug Anxiety0.20.20.40.20.6
Baseline Anxiety0.71.11.21.0-1.1
Tail length0.42.14.1-2.0-0.4
Length with tail0.73.06.0-2.5-0.1
Length without tail0.10.50.9-1.0-0.2
Times rat made contact with spout0.10.10.1-0.3-0.2
Lifetime Intake0.50.61.1-1.00.4
Liver weight, left2.54.45.2-2.31.9
Liver weight, right0.81.41.80.9-1.4
Locomotor activity0.50.81.6-1.30.2
Locomotor testing distance0.30.71.5-1.2-0.1
Locomotor testing rearing0.20.81.1-0.7-1.0
Locomotion in novel chamber1.11.51.71.3-1.1
Locomotion in novel chamber post-restriction0.00.00.10.00.3
Fecal boli incidents, locomotor time 10.92.32.8-1.41.7
Change in fecal boli incidents, locomotor task0.30.30.40.6-0.4
Time >=10cm from walls, locomotor time 10.50.60.80.9-0.5
Bouts of movement, locomotor time 10.10.10.20.0-0.5
Total resting periods, locomotor time 10.00.00.0-0.0-0.1
Rest time, locomotor task time 10.10.20.30.5-0.1
Distance moved, locomotor task time 10.82.33.11.2-1.8
Vertical activity count, locomotor time 10.21.52.01.0-1.4
Time >=10cm from walls, locomotor time 21.54.45.31.9-2.3
Bouts of movement, locomotor time 20.93.05.30.9-2.3
Total resting periods, locomotor time 20.62.44.30.8-2.1
Rest time, locomotor task time 20.30.61.11.00.2
Distance moved, locomotor task time 23.95.26.42.0-2.5
Vertical activity count, locomotor time 20.30.81.40.5-1.2
Light reinforcement 10.31.32.10.7-1.4
Light reinforcement 20.10.10.20.2-0.5
Bone: marrow area15.036.740.5-6.45.7
Bone: maximum diameter6.012.112.6-3.53.4
Bone: maximum force2.34.65.3-2.32.0
Bone: maximum moment2.54.75.3-2.32.0
Mean time between licks in bursts0.00.20.2-0.5-0.4
Mean num. licks in bursts0.00.10.10.3-0.3
Cd content in liver0.50.51.11.00.0
Co content in liver0.20.30.40.6-0.4
Cu content in liver0.40.40.5-0.60.7
Fe content in liver0.30.30.3-0.60.6
K content in liver0.70.71.3-0.41.1
Mg content in liver0.60.71.30.41.1
Mn content in liver0.60.71.30.31.1
Na content in liver0.10.10.30.50.0
Rb content in liver0.91.01.81.3-0.6
Se content in liver0.40.40.50.7-0.6
Sr content in liver0.20.20.3-0.6-0.2
Zn content in liver1.21.41.9-0.91.4
Bone: minimum diameter14.026.833.0-5.74.5
Time in familiar zone, hab. session 11.11.21.6-1.30.9
Time in novel zone, hab. session 10.30.40.50.7-0.4
Total zone transitions, hab. session 10.10.10.3-0.1-0.5
Total locomotion distance, hab. session 10.40.61.10.4-1.0
Locomotion velocity, hab. session 10.50.71.20.4-1.1
Time in familiar zone, hab. session 21.11.21.9-1.40.7
Time in novel zone, hab. session 20.91.02.01.4-0.2
Total zone transitions, hab. session 20.40.51.00.3-1.0
Total locomotion distance, hab. session 21.92.53.71.1-1.9
Locomotion velocity, hab. session 22.33.04.01.4-2.0
Novel to familiar place preference ratio2.83.75.2-2.31.5
Novelty place preference2.02.63.6-1.91.3
Time in novel zone, NPP test2.02.53.4-1.81.3
Total zone transitions, NPP test0.20.30.50.4-0.7
Total locomotion distance, NPP test0.70.91.00.9-1.0
Locomotion velocity, NPP test1.01.52.01.0-1.4
Intraocular pressure0.71.22.3-1.50.2
Delta distance traveled before/after self-admin0.10.10.1-0.40.2
Delta ambulatory time before/after self-admin1.01.81.9-1.31.4
Parametrial fat weight0.30.61.20.21.1
Pavlov. Cond. lever latency0.30.40.60.50.8
Pavlov. Cond. magazine entry latency0.30.40.7-0.80.4
Pavlov. Cond. change in total contacts0.60.71.3-1.20.2
Pavlov. Cond. index score0.40.50.9-1.00.1
Pavlov. Cond. latency score0.30.40.8-0.9-0.1
Pavlov. Cond. lever contacts0.20.30.3-0.5-0.6
Pavlov. Cond. magazine entry number0.40.50.70.8-0.5
Pavlov. Cond. intertrial magazine entries3.74.47.6-2.81.1
Pavlov. Cond. lever-magazine prob. diff.0.50.61.1-1.00.3
Pavlov. Cond. response bias0.30.40.6-0.70.4
Pavlov. Cond. lever latency2.43.43.41.8-1.8
Pavlov. Cond. magazine entry latency0.10.10.10.3-0.4
Pavlov. Cond. change in total contacts0.92.22.5-1.61.4
Pavlov. Cond. index score1.52.32.5-1.61.4
Pavlov. Cond. latency score1.11.82.1-1.41.3
Pavlov. Cond. lever contacts1.82.72.8-1.61.7
Pavlov. Cond. magazine entry number0.20.20.4-0.40.6
Pavlov. Cond. intertrial magazine entries0.81.71.9-1.21.4
Pavlov. Cond. lever-magazine prob. diff.1.32.02.2-1.51.3
Pavlov. Cond. response bias1.82.52.6-1.51.6
Time in closed arm before self-admin0.20.40.8-0.1-0.9
Time in closed arm after self-admin0.40.40.70.4-0.8
Time in open arm before self-admin0.50.60.90.5-1.0
Time in open arm after self-admin0.10.10.1-0.1-0.4
Bone: periosteal estimation10.324.428.6-5.44.5
Bone: periosteal perimeter7.414.518.0-4.23.3
Bone: post-yield work3.66.27.2-2.72.3
Progressive ratio test 1 active lever presses0.30.61.1-0.3-1.1
Progressive ratio test 1 breakpoint0.30.50.8-0.4-0.9
Progressive ratio test 1 inactive lever presses0.30.71.4-1.20.1
Progressive ratio test 2 active lever presses0.20.20.5-0.0-0.7
Progressive ratio test 2 breakpoint0.20.20.4-0.1-0.7
Progressive ratio test 2 inactive lever presses0.00.10.1-0.1-0.3
Incentive Sensitization - Responses0.00.10.2-0.0-0.5
Incentive Sensitization - Breakpoint0.10.10.20.0-0.5
Sum of active levers in priming session hrs 5-61.31.31.51.0-1.2
Progressive ratio0.00.00.0-0.1-0.1
Food seeking constrained by brief footshock0.81.01.2-0.81.1
Seeking ratio, punishment vs. effort0.10.20.2-0.40.4
Retroperitoneal fat weight0.52.44.80.2-2.2
Reaction time number correct0.00.10.10.20.4
Reaction time mean minus median0.00.30.50.7-0.3
Reaction time mean minus median AUC0.00.20.50.20.7
Reaction time num false alarms2.23.76.1-2.51.1
Reaction time num false alarms AUC2.14.87.0-2.61.6
Reaction time trials correct on left0.00.10.10.20.4
Reaction time trials on left0.00.10.20.10.5
Reaction time mean0.20.40.80.90.2
Reaction time mean AUC0.30.61.21.1-0.0
Median of all reaction times0.30.50.91.00.3
Reaction time omissions0.20.40.80.00.9
Reaction time false alarm rate2.13.04.9-2.21.0
Reaction time premature initiation rate0.60.91.9-1.40.1
Reaction time premature initiations0.31.01.8-1.30.6
Std. dev. reaction times0.10.40.70.80.4
Reaction time trials completed0.00.10.20.10.5
Reaction time trials AUC0.00.10.10.30.3
Run reversals in cocaine runway, females3.84.26.41.4-2.5
Run reversals in cocaine runway, males0.10.10.2-0.00.4
Latency to leave start box in cocaine runway4.66.38.12.1-2.9
Latency to leave start box in cocaine runway, F4.75.99.21.6-3.0
Latency to leave start box in cocaine runway, M1.91.82.61.6-1.0
Std. dev. time between licks in bursts1.22.32.31.5-1.5
Total sessions with >9 infusions0.80.91.80.2-1.4
Short access day 1 total inactive lever presses0.10.20.4-0.1-0.6
Short access day 10 total inactive lever presses0.00.10.10.00.4
Short access day 1 total infusions0.50.91.80.2-1.3
Short access day 10 total infusions0.50.81.6-1.2-0.0
Short access total infusions0.20.30.5-0.7-0.1
Short access day 1 locomotion0.91.42.8-0.3-1.7
Short access day 10 total locomotion0.31.42.5-1.60.5
Short access total locomotion0.40.60.8-0.7-0.9
One hour access (0.3 mA shock)1.41.72.0-1.41.2
Compulsive drug intake2.13.13.4-1.71.8
One hour access (shock baseline)0.00.00.0-0.10.1
Social response proportion1.31.62.1-1.11.4
Social responses0.81.11.6-1.30.8
Social time1.11.82.2-1.11.5
Soleus weight0.41.11.9-1.40.5
Bone: stiffness1.01.81.8-1.31.3
Tibialis anterior weight0.20.81.60.0-1.3
Time to tail flick, vehicle, before self-admin0.10.10.10.30.4
Time to tail flick, vehicle, after self-admin0.10.20.3-0.30.6
Time to tail flick, test, before self-admin2.62.93.7-1.91.5
Time to tail flick, test, after self-admin1.61.71.7-1.31.3
Delta time to tail flick, vehicle, before/after SA0.60.60.9-0.70.9
Delta time to tail flick, test, before/after SA0.20.30.5-0.20.7
Tibia length0.20.71.2-0.3-1.1
Ambulatory time before self-admin1.23.63.81.8-1.9
Ambulatory time after self-admin0.20.30.40.5-0.7
Bone: tissue strength0.60.60.90.9-0.7
Total heroin consumption0.00.10.10.30.1
Bone: trabecular number2.65.08.6-1.22.9
Bone: trabecular spacing2.33.35.11.2-2.3
Bone: trabecular thickness3.75.15.7-2.12.4
Bone: trabecular tissue density1.52.63.01.5-1.7
Water consumed over 24 hours1.63.23.51.7-1.9
Number of responses in last shaping day0.81.11.50.8-1.2