Hub : Genes

Glod4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IL	gene expression	Glod4	0.53	0.15	1.1e-03	0.03	0.12	0	-0	6.1e-02	9.0e-04	3.2e-01	4.2e-01
2	PL	gene expression	Glod4	0.39	0.14	5.2e-08	0.04	0.07	0.05	0.04	2.2e-05	2.3e-08	1.9e-06	1.1e-05
3	RMTg	gene expression	Glod4	0.12	0.09	1.0e-03	0.02	0.03	0	0.01	8.1e-02	4.9e-02	2.3e-01	2.2e-01
4	NAcc	mRNA stability	Glod4	0.02	0.02	7.8e-03	0	0	0	0	5.1e-02	7.5e-02	2.4e-01	8.7e-02
5	pVTA	gene expression	Glod4	0.03	0.03	2.4e-03	0.03	0.03	0.03	0.03	1.8e-03	1.6e-03	4.2e-03	2.5e-03
6	Brain	gene expression	Glod4	0.03	0.02	4.3e-04	0.04	0.03	0.02	0.04	7.5e-05	4.8e-04	3.0e-03	1.1e-04
7	Liver	gene expression	Glod4	0.08	0.05	7.8e-07	0.04	0.05	0.04	0.04	9.1e-05	7.3e-06	3.8e-05	3.3e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	2.1	3.9	5.3	-2.2	-1.9	-2.3	-1.8	-2.0	2.1	-1.5
Area under the delay curve	0.6	0.9	2.1	1.4	0.9	1.1	0.5	0.8	-1.1	0.5
BMI with tail	0.2	0.7	1.9	0.3	0.5	-1.1	-1.4	-0.9	0.7	-0.5
BMI without tail	0.7	3.5	5.0	-0.5	-0.8	-2.2	-2.1	-2.2	2.2	-2.2
Body weight	2.5	11.1	16.3	-1.8	-2.5	-3.6	-3.4	-3.8	3.6	-4.0
Weight adjusted by age	0.1	0.2	0.5	0.7	0.7	0.1	0.1	0.1	0.1	0.4
Bone surface	0.7	1.4	2.5	-0.8	-0.6	-1.5	-1.2	-1.3	1.6	-0.8
Bone volume	0.8	1.7	2.7	-1.1	-1.0	-1.7	-1.2	-1.5	1.5	-1.0
Breakpoint value in progressive ratio session	1.1	2.1	2.5	-1.3	-1.2	-1.6	-1.5	-1.4	1.5	-1.5
Number of licking bursts	0.1	0.3	0.9	-0.3	-0.7	0.5	0.9	0.2	-0.5	-0.2
Context. condit. distance diff. score	1.2	1.5	2.7	-1.6	-1.5	-1.3	-1.0	-1.2	0.9	-0.8
Locomotion velocity, session 1	2.4	2.7	3.9	-1.1	-1.3	-2.0	-1.6	-2.0	1.8	-1.6
Locomotion distance, session 1	0.1	0.1	0.2	-0.1	0.1	-0.3	-0.5	-0.2	0.2	-0.1
Locomotion velocity, session 2	0.2	0.2	0.5	-0.1	-0.1	-0.6	-0.7	-0.6	0.5	-0.3
Locomotion distance, session 2	0.4	0.6	1.5	-0.7	-0.3	-0.9	-1.2	-0.6	0.9	-0.3
Locomotion velocity, session 3	2.2	2.6	6.9	2.6	1.8	1.7	1.2	1.2	-1.3	0.5
Locomotion distance, session 3	1.2	1.4	3.7	1.8	1.9	0.8	0.6	0.8	-0.4	0.8
Stereotopy head waving bouts, day 3	0.4	0.4	0.8	-0.4	-0.8	-0.6	-0.5	-0.8	0.5	-0.9
Stereotopy head waving duration, day 3	0.2	0.2	0.6	0.3	-0.1	0.5	0.6	0.3	-0.8	0.1
Locomotion velocity, session 7	0.2	0.2	0.8	0.6	0.9	-0.2	-0.1	-0.0	0.3	0.4
Locomotion distance, session 7	0.1	0.2	0.4	0.2	0.5	-0.5	-0.2	-0.3	0.6	0.2
Stereotopy head waving bouts, day 7	0.7	0.8	1.2	-0.4	-0.8	-1.0	-0.8	-1.1	0.9	-1.1
Stereotopy head waving duration, day 7	0.5	0.7	1.0	-0.4	-0.7	-0.9	-0.8	-1.0	0.9	-0.9
Locomotion velocity, session 8	0.0	0.0	0.1	-0.3	0.1	-0.1	0.0	0.0	-0.1	0.2
Locomotion distance, session 8	1.2	1.8	2.5	-1.0	-1.1	-1.6	-1.4	-1.6	1.4	-1.2
Degree of sensitization distance	2.0	2.2	4.0	-2.0	-1.8	-1.5	-1.3	-1.3	1.3	-1.0
Degree of sensitization stereotypy	1.1	1.2	1.5	-0.8	-1.1	-1.2	-1.0	-1.2	1.1	-1.1
Conditioned locomotion	0.2	0.2	0.4	0.2	0.1	0.6	0.5	0.6	-0.6	0.6
Cocaine response after cond. corrected	1.0	1.4	3.0	-1.7	-1.6	-1.1	-1.2	-0.9	0.6	-0.9
Cocaine response after cond. not corrected	1.2	1.7	3.0	-1.7	-1.6	-1.3	-1.3	-1.1	0.8	-1.1
Cocaine response before conditioning	0.1	0.2	0.3	0.2	0.3	-0.5	-0.2	-0.5	0.5	-0.4
Saline control response	0.2	0.3	1.0	1.0	0.8	0.4	0.7	0.2	-0.2	0.3
Bone: connectivity density	2.6	4.1	5.7	-2.3	-1.6	-2.4	-2.2	-1.9	2.3	-1.3
Bone: cortical apparent density	0.5	0.8	1.4	-0.6	0.2	0.9	0.7	1.2	-1.1	1.1
Bone: cortical area	2.0	3.2	8.7	3.0	2.4	1.6	1.6	1.1	-0.8	1.0
Bone: cortical porosity	0.2	0.2	0.5	-0.5	-0.4	-0.5	-0.7	-0.4	0.1	-0.4
Bone: cortical porosity	0.0	0.0	0.2	-0.0	-0.0	-0.1	-0.5	-0.1	-0.2	-0.2
Bone: cortical thickness	2.1	3.5	9.0	3.0	2.2	2.0	1.6	1.4	-1.3	0.7
Bone: cortical thickness	0.3	0.3	1.7	1.3	0.6	0.3	0.1	-0.1	-0.1	-0.4
Bone: cortical tissue density	0.4	0.6	1.0	-0.8	-0.0	0.6	0.6	1.0	-0.8	0.9
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.5	0.2	-0.1	-0.4	-0.2	0.3	-0.4
Condit. Reinf. active-inactive response ratio	0.4	0.5	1.6	1.3	0.4	0.1	-0.4	-0.4	0.6	-0.9
Condit. Reinf. active responses	0.2	0.2	0.7	-0.5	-0.3	-0.4	-0.8	-0.3	0.3	-0.2
Condit. Reinf. inactive responses	0.6	0.8	3.7	-1.9	-0.8	-0.3	-0.2	0.4	-0.6	0.9
Incentive salience index mean	0.3	0.3	0.8	0.7	0.4	-0.3	-0.9	-0.5	0.5	-0.6
Condit. Reinf. lever presses	0.7	1.1	2.4	0.2	-0.0	-1.2	-1.5	-1.3	1.0	-1.1
Condit. Reinf. active minus inactive responses	0.0	0.1	0.2	0.1	0.1	-0.2	0.3	-0.3	0.4	-0.0
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.2	-0.1	-0.2	0.4	-0.4	0.3	-0.3
Condit. Reinf. active responses	0.1	0.2	0.4	0.5	0.6	0.2	0.5	0.2	-0.1	0.4
Condit. Reinf. inactive responses	0.4	0.7	1.2	0.5	1.1	0.6	0.4	0.9	-0.8	1.1
Condit. Reinf. lever presses	1.7	2.5	2.9	1.4	1.6	1.6	1.7	1.6	-1.7	1.4
Condit. Reinf. lever reinforcers received	0.3	0.4	0.8	0.8	0.9	0.4	0.7	0.4	-0.2	0.6
Conditioned reinforcement - actives	0.1	0.2	0.5	-0.6	-0.2	-0.5	-0.7	-0.3	0.4	0.2
Conditioned reinforcement - inactives	0.0	0.0	0.1	0.2	0.2	-0.1	0.4	-0.2	0.2	0.1
Conditioned locomotion	0.7	1.0	1.9	0.9	1.4	1.0	0.3	1.2	-1.0	1.0
Patch foraging indifference point 0 sec	0.1	0.4	1.3	1.1	1.1	0.2	0.0	0.2	-0.1	0.4
Patch foraging indifference point AUC	0.5	1.1	2.6	1.0	0.8	1.0	1.6	0.8	-0.8	1.1
Delay disc. indifference point, 0s delay	0.3	0.3	1.6	1.3	0.2	0.1	-0.1	-0.4	0.4	-0.3
Delay disc. indifference point, 16s delay	0.4	0.6	1.2	0.7	0.3	1.0	0.8	0.7	-1.1	0.4
Delay disc. indifference point, 2s delay	0.6	0.7	1.3	1.2	0.6	1.0	0.8	0.6	-1.1	0.3
Delay disc. indifference point, 24s delay	0.1	0.2	0.3	0.2	0.4	0.5	-0.2	0.6	-0.5	0.4
Delay disc. indifference point, 4s delay	0.1	0.2	0.3	-0.5	-0.5	0.2	-0.5	0.1	-0.4	-0.3
Delay disc. indifference point, 8s delay	0.2	0.4	0.8	0.9	0.5	0.7	0.2	0.4	-0.8	0.2
Indifference point function ln k	0.3	0.9	2.7	-1.1	-0.5	-0.9	-1.6	-0.6	0.6	-0.5
Indifference point function log k	0.3	0.9	2.7	-1.1	-0.5	-0.9	-1.6	-0.6	0.6	-0.5
Patch foraging total patch changes 0 sec	0.1	0.4	1.3	1.1	1.1	0.2	0.1	0.2	-0.1	0.5
Patch foraging total patch changes 12 sec	0.6	0.8	2.5	1.6	1.2	0.6	0.8	0.4	-0.3	0.3
Patch foraging total patch changes 18 sec	0.2	0.4	1.3	1.2	0.5	0.6	0.9	0.1	-0.3	-0.2
Patch foraging total patch changes 24 sec	0.3	1.1	2.7	1.6	1.3	1.0	0.9	0.7	-0.6	0.6
Patch foraging total patch changes 6 sec	1.8	3.1	6.3	2.5	2.0	1.5	2.0	1.1	-1.4	1.3
Patch foraging time to switch 0 sec	0.2	0.7	1.8	-0.8	-1.2	-0.5	-0.6	-0.7	0.3	-1.3
Patch foraging water rate 0 sec	0.5	1.8	2.9	1.7	1.7	1.1	1.4	1.0	-0.6	1.5
Patch foraging water rate 12 sec	0.0	0.0	0.1	-0.3	-0.1	-0.0	0.2	-0.0	-0.2	-0.1
Patch foraging water rate 18 sec	0.3	0.7	1.6	-1.3	-1.0	-1.0	-0.5	-0.7	0.6	-0.4
Patch foraging water rate 24 sec	0.5	0.7	1.4	1.2	1.2	0.6	0.6	0.5	-0.6	0.7
Patch foraging water rate 6 sec	0.8	1.3	1.9	1.2	1.4	1.1	1.0	1.1	-0.8	1.2
Seeking ratio, delayed vs. immediate footshock	2.2	3.1	5.6	1.9	1.6	1.8	2.4	1.6	-1.5	1.3
Distance traveled before self-admin	1.4	3.1	6.1	1.8	1.3	2.1	2.5	1.6	-1.6	1.1
Distance traveled after self-admin	0.1	0.2	0.6	0.3	0.2	0.5	0.8	0.4	-0.3	0.2
Extensor digitorum longus weight	0.6	2.2	4.6	-1.5	-0.8	-2.1	-1.2	-1.5	2.1	-0.3
Bone: elastic displacement	0.7	0.9	1.5	0.5	0.7	1.0	1.0	1.0	-1.2	1.0
Bone: elastic work	3.9	5.1	13.7	3.7	3.0	2.1	1.6	1.5	-1.5	1.1
Bone: endosteal estimation	0.2	0.4	1.2	1.1	0.7	0.2	1.1	-0.0	-0.0	0.3
Bone: endosteal perimeter	0.1	0.2	0.8	0.3	0.4	0.2	0.9	0.3	0.0	0.8
Epididymis fat weight	4.6	23.4	27.5	-5.2	-4.9	-5.2	-4.8	-4.7	4.7	-4.1
Delta time in closed arm before/after self-admin	0.7	0.7	1.1	-0.7	-0.4	0.9	0.8	1.0	-1.0	0.8
Delta time in open arm before/after self-admin	0.5	0.6	1.5	-0.1	0.2	-1.0	-1.2	-0.8	0.8	-0.8
Diff in mean of infusions in LGA sessions	0.8	1.4	2.0	-1.0	-0.7	-1.4	-1.4	-1.2	1.4	-1.0
Delay discount exponential model param	0.5	0.7	1.4	-1.2	-0.8	-0.9	-0.3	-0.7	1.0	-0.4
Extinction: sum of active levers before priming	0.3	0.5	1.4	-1.2	-0.3	-0.8	-0.8	-0.4	0.5	-0.0
Active lever presses in extinction session 6	0.6	0.6	1.0	-0.9	-0.5	-1.0	-0.7	-0.8	0.8	-0.4
Bone: final force	1.8	2.9	13.2	3.6	2.5	0.6	0.1	-0.1	0.4	-0.3
Bone: final moment	1.8	2.9	12.6	3.6	2.6	0.6	0.1	0.1	0.2	-0.1
Food consumed during 24 hour testing period	0.0	0.1	0.2	0.3	0.4	-0.4	-0.1	-0.3	0.4	-0.0
Glucose	1.8	2.8	4.3	1.5	1.5	2.1	1.6	1.9	-1.8	1.3
Heart weight	1.7	2.7	5.8	-0.6	-0.9	-1.8	-1.7	-1.8	2.4	-1.6
Delay discount hyperbolic model param	0.6	0.7	1.8	-1.3	-0.8	-1.0	-0.3	-0.7	1.0	-0.3
Intermittent access intake day 1-15 change	0.2	1.1	1.9	-0.1	0.7	1.0	1.2	1.4	-0.8	1.3
Intermittent access intake escalation	0.2	1.3	2.3	0.1	1.1	1.1	1.2	1.5	-0.9	1.5
Intermittent access intake escalation 2	0.8	1.3	2.1	0.1	0.7	1.2	1.3	1.4	-1.2	1.4
Intermitt. access day 1 inactive lever presses	0.3	3.3	4.5	1.3	2.0	1.9	1.7	2.1	-1.7	1.9
Intermitt. access day 15 inactive lever presses	0.6	3.0	4.9	-0.1	0.5	1.8	2.2	2.1	-2.1	1.9
Intermitt. access escalation Index	1.3	4.2	5.3	-1.7	-2.3	-1.9	-2.2	-2.0	2.1	-2.1
Intermittent access day 1 total infusions	0.0	0.1	0.4	-0.0	-0.1	0.2	0.4	0.1	-0.6	-0.0
Intermittent access day 15 total infusions	0.2	0.5	0.9	0.1	0.7	0.6	0.7	0.9	-0.8	0.9
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.5	-0.7	-0.2	-0.1	0.2	0.1	-0.2	0.3
Intermittent access total infusions	0.4	0.4	0.7	0.3	0.6	0.5	0.8	0.6	-0.8	0.7
Intermittent access day 1 locomotion	0.5	1.0	2.5	1.6	1.3	0.7	1.1	0.4	-0.8	0.2
Intermittent access day 15 total locomotion	0.2	0.8	2.1	0.6	0.8	0.8	1.5	0.9	-0.7	0.7
Intermittent access total locomotion	0.6	0.7	1.3	0.9	1.1	0.7	1.0	0.8	-0.6	0.7
Intermittent access standard deviation	0.5	2.6	4.3	0.2	1.2	1.4	2.0	1.8	-1.7	2.1
Left kidney weight	0.1	0.5	2.2	1.0	0.1	0.2	-0.2	-0.3	0.2	-1.5
Right kidney weight	0.1	0.9	3.8	0.6	-0.3	-0.4	-0.7	-0.9	0.8	-2.0
Cocaine induced anxiety	0.1	0.2	0.6	-0.8	-0.5	0.2	-0.1	0.4	-0.6	0.4
Post-drug Anxiety	2.0	2.3	5.2	-2.3	-2.0	-1.4	-1.3	-1.2	0.7	-1.2
Baseline Anxiety	1.1	1.9	2.3	-1.4	-1.4	-1.5	-1.0	-1.5	1.4	-1.3
Tail length	1.8	9.4	15.3	-1.6	-2.8	-3.0	-2.5	-3.5	3.6	-3.9
Length with tail	2.6	11.7	18.8	-2.3	-3.6	-3.2	-2.7	-3.7	3.7	-4.3
Length without tail	0.8	4.3	6.4	-1.8	-2.4	-2.0	-1.8	-2.2	1.8	-2.5
Times rat made contact with spout	0.6	0.7	3.1	1.8	1.2	0.4	0.4	0.0	0.1	-0.3
Lifetime Intake	0.3	0.4	0.8	0.2	0.6	0.5	0.7	0.6	-0.9	0.7
Liver weight, left	7.7	13.3	17.0	-2.8	-3.6	-3.8	-3.2	-4.1	3.7	-4.1
Liver weight, right	6.7	11.6	13.6	-3.0	-3.5	-3.6	-3.4	-3.6	3.0	-3.7
Locomotor activity	0.0	0.0	0.1	-0.1	-0.2	-0.2	0.2	-0.2	0.2	-0.2
Locomotor testing distance	0.0	0.1	0.3	0.2	-0.3	0.0	0.5	-0.2	0.1	-0.2
Locomotor testing rearing	0.0	0.2	0.8	-0.4	-0.3	0.1	0.9	0.1	-0.2	0.3
Locomotion in novel chamber	4.5	6.1	8.3	1.4	2.3	2.6	2.3	2.9	-2.7	2.8
Locomotion in novel chamber post-restriction	0.1	0.2	0.4	-0.3	0.4	0.1	-0.3	0.5	-0.4	0.6
Fecal boli incidents, locomotor time 1	0.1	0.3	1.0	-0.5	-0.3	-0.5	-1.0	-0.3	0.2	-0.5
Change in fecal boli incidents, locomotor task	0.1	0.1	0.4	0.1	-0.2	0.0	0.6	-0.1	0.0	-0.1
Time >=10cm from walls, locomotor time 1	1.3	1.6	5.1	2.3	2.3	0.4	-0.1	0.3	-0.1	0.7
Bouts of movement, locomotor time 1	0.1	0.1	0.6	0.8	0.5	-0.0	-0.0	-0.2	-0.1	0.2
Total resting periods, locomotor time 1	0.1	0.1	0.2	0.4	0.4	0.0	0.3	0.0	-0.3	0.4
Rest time, locomotor task time 1	0.4	0.7	1.6	-0.6	-0.1	0.5	1.2	0.7	-1.3	0.8
Distance moved, locomotor task time 1	0.0	0.1	0.3	0.5	0.4	0.0	-0.6	-0.0	0.4	0.1
Vertical activity count, locomotor time 1	0.0	0.2	0.8	0.3	0.2	-0.3	-0.9	-0.3	0.7	-0.2
Time >=10cm from walls, locomotor time 2	0.9	2.6	8.6	2.9	2.8	0.9	-0.1	0.8	-0.5	0.7
Bouts of movement, locomotor time 2	0.0	0.1	0.3	-0.5	-0.5	0.0	0.1	-0.0	-0.3	-0.1
Total resting periods, locomotor time 2	0.0	0.1	0.4	-0.6	-0.6	-0.3	-0.1	-0.2	-0.2	-0.2
Rest time, locomotor task time 2	0.5	0.9	3.1	-1.8	-1.5	-0.4	0.9	-0.2	-0.2	-0.0
Distance moved, locomotor task time 2	0.4	0.5	0.8	0.5	0.7	0.8	0.0	0.9	-0.9	0.7
Vertical activity count, locomotor time 2	0.1	0.1	0.4	0.6	0.4	0.5	-0.1	0.3	-0.2	0.0
Light reinforcement 1	0.0	0.0	0.1	-0.2	-0.3	0.1	-0.0	-0.0	-0.1	-0.3
Light reinforcement 2	0.2	0.4	1.1	1.0	0.5	0.9	0.6	0.6	-0.5	-0.2
Bone: marrow area	0.2	0.4	1.2	1.1	0.7	0.2	1.1	-0.0	-0.0	0.3
Bone: maximum diameter	1.2	2.4	5.1	2.3	2.2	1.1	1.5	1.0	-0.5	1.4
Bone: maximum force	1.5	2.9	12.9	3.6	2.5	0.8	0.8	0.1	0.2	-0.1
Bone: maximum moment	1.5	2.8	11.8	3.4	2.5	0.9	0.8	0.3	-0.1	0.2
Mean time between licks in bursts	0.2	1.3	1.9	-0.7	-1.2	-1.0	-0.9	-1.3	1.3	-1.4
Mean num. licks in bursts	0.3	0.7	2.2	1.4	1.5	-0.3	-0.6	-0.3	0.6	-0.1
Cd content in liver	0.8	0.9	2.9	-1.7	-1.3	-0.0	1.0	0.1	0.1	0.5
Co content in liver	0.3	0.3	0.9	0.9	0.8	0.4	0.5	0.3	-0.3	0.3
Cu content in liver	1.0	1.1	2.9	1.7	1.3	1.0	1.0	0.7	-0.6	0.7
Fe content in liver	0.9	1.1	1.5	-0.9	-1.1	-1.0	-1.0	-1.1	0.9	-1.2
K content in liver	0.8	0.8	1.5	1.2	0.5	-0.4	-0.6	-0.8	1.2	-1.1
Mg content in liver	0.5	0.5	1.8	1.3	1.1	0.4	0.5	0.2	0.3	0.4
Mn content in liver	0.2	0.2	0.5	0.2	0.6	0.2	0.3	0.4	-0.2	0.7
Na content in liver	0.3	0.3	0.7	0.9	0.5	0.7	0.2	0.5	-0.8	-0.1
Rb content in liver	0.2	0.3	1.3	-0.0	0.2	-0.6	-0.0	-0.4	1.1	0.3
Se content in liver	0.3	0.4	1.2	1.1	0.9	0.6	0.3	0.4	-0.5	0.3
Sr content in liver	0.2	0.2	0.6	-0.8	-0.2	-0.4	-0.3	-0.1	-0.1	0.4
Zn content in liver	0.4	0.4	0.7	-0.5	-0.5	-0.8	-0.5	-0.8	0.7	-0.6
Bone: minimum diameter	0.2	0.3	1.0	1.0	0.2	0.4	1.0	0.0	0.0	-0.3
Time in familiar zone, hab. session 1	0.6	0.6	1.6	0.4	1.0	0.5	0.8	0.8	-0.5	1.3
Time in novel zone, hab. session 1	0.3	0.4	1.1	-0.3	-0.9	-0.3	-0.4	-0.6	0.3	-1.0
Total zone transitions, hab. session 1	0.1	0.1	0.2	-0.4	0.0	0.2	0.1	0.4	0.0	0.5
Total locomotion distance, hab. session 1	0.3	0.4	1.1	-1.0	-1.1	-0.4	-0.5	-0.4	0.3	-0.3
Locomotion velocity, hab. session 1	0.1	0.1	0.2	-0.5	-0.5	-0.1	-0.3	-0.1	0.2	-0.0
Time in familiar zone, hab. session 2	0.1	0.1	0.3	-0.5	-0.6	-0.4	0.1	-0.4	0.3	-0.0
Time in novel zone, hab. session 2	0.6	0.6	1.6	1.3	1.1	0.9	0.3	0.7	-0.5	0.2
Total zone transitions, hab. session 2	0.5	0.7	1.3	-1.0	-0.8	-0.7	-1.2	-0.5	0.7	-0.7
Total locomotion distance, hab. session 2	0.3	0.4	0.8	-0.7	-0.7	-0.5	-0.9	-0.4	0.4	-0.6
Locomotion velocity, hab. session 2	0.2	0.3	0.7	-0.7	-0.7	-0.4	-0.8	-0.4	0.3	-0.5
Novel to familiar place preference ratio	0.4	0.6	1.1	0.5	1.0	0.6	0.2	0.9	-0.7	1.0
Novelty place preference	0.2	0.2	0.4	0.3	0.7	0.3	-0.1	0.5	-0.4	0.6
Time in novel zone, NPP test	0.1	0.1	0.2	0.1	0.4	0.0	-0.3	0.3	-0.0	0.4
Total zone transitions, NPP test	0.1	0.1	0.4	-0.7	-0.4	-0.2	-0.4	-0.0	0.3	-0.1
Total locomotion distance, NPP test	0.1	0.1	0.3	-0.4	-0.2	0.4	0.1	0.4	-0.5	0.3
Locomotion velocity, NPP test	0.4	0.5	1.1	-0.1	0.2	0.8	0.5	0.9	-1.0	0.8
Intraocular pressure	1.0	1.6	2.7	0.3	0.5	1.4	1.6	1.5	-1.2	1.6
Delta distance traveled before/after self-admin	1.4	1.6	2.5	-1.0	-0.7	-1.6	-1.6	-1.3	1.3	-1.0
Delta ambulatory time before/after self-admin	0.9	1.5	2.7	-1.1	-0.8	-1.5	-1.6	-1.3	1.3	-0.8
Parametrial fat weight	6.7	15.9	19.6	-4.0	-3.8	-4.4	-4.0	-4.1	3.9	-3.6
Pavlov. Cond. lever latency	0.2	0.2	0.5	-0.7	-0.3	0.3	0.7	0.5	-0.3	0.6
Pavlov. Cond. magazine entry latency	0.6	0.7	1.1	-0.3	-0.5	-1.0	-0.9	-1.0	1.0	-0.9
Pavlov. Cond. change in total contacts	0.2	0.2	0.3	0.6	0.4	0.5	0.5	0.3	-0.3	0.1
Pavlov. Cond. index score	0.4	0.6	0.9	0.4	0.0	-0.8	-0.8	-1.0	0.8	-0.9
Pavlov. Cond. latency score	0.6	0.8	1.3	0.5	-0.0	-0.9	-1.0	-1.1	1.0	-1.1
Pavlov. Cond. lever contacts	0.2	0.2	0.4	0.6	0.4	-0.3	-0.6	-0.4	0.3	-0.5
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	0.3	0.4	0.5	0.4	0.5	-0.5	0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.8	-0.4	-0.2	0.6	0.4	0.7	-0.9	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.6	0.4	0.1	-0.7	-0.7	-0.8	0.7	-0.7
Pavlov. Cond. response bias	0.4	0.4	0.6	-0.3	-0.4	-0.8	-0.7	-0.8	0.8	-0.7
Pavlov. Cond. lever latency	1.5	2.1	3.6	-1.3	-1.1	-1.6	-1.9	-1.4	1.6	-0.9
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.2	0.0	0.4	-0.0	0.3	-0.0	-0.5
Pavlov. Cond. change in total contacts	0.8	2.1	5.0	2.2	1.7	1.4	1.6	1.0	-0.7	0.6
Pavlov. Cond. index score	1.2	1.9	3.0	1.3	1.1	1.7	1.7	1.4	-1.4	0.8
Pavlov. Cond. latency score	1.5	2.4	3.8	1.5	1.3	1.8	1.9	1.6	-1.5	1.0
Pavlov. Cond. lever contacts	0.6	0.9	1.7	1.0	0.7	1.1	1.3	0.8	-1.1	0.4
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	-0.6	-0.5	-0.7	-0.3	-0.5	0.2	0.2
Pavlov. Cond. intertrial magazine entries	0.4	0.8	1.4	-1.2	-1.0	-1.0	-0.9	-0.8	0.5	-0.3
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.7	2.6	1.2	1.1	1.6	1.6	1.4	-1.3	0.8
Pavlov. Cond. response bias	0.5	0.7	1.3	0.8	0.6	1.0	1.1	0.8	-0.9	0.2
Time in closed arm before self-admin	1.1	1.9	3.4	-0.3	-0.9	-1.6	-1.1	-1.8	1.6	-1.5
Time in closed arm after self-admin	0.1	0.2	0.7	0.3	-0.3	0.4	0.8	0.1	-0.3	0.0
Time in open arm before self-admin	1.9	2.4	4.4	0.8	1.0	1.8	1.6	1.7	-2.1	1.3
Time in open arm after self-admin	1.0	1.1	2.3	0.7	1.5	0.9	0.2	1.2	-1.1	1.0
Bone: periosteal estimation	0.8	1.9	6.5	2.6	1.7	1.0	1.6	0.4	-0.3	0.5
Bone: periosteal perimeter	0.7	1.3	3.0	1.7	1.6	0.9	1.2	0.7	-0.5	0.9
Bone: post-yield work	0.4	0.7	1.8	-0.2	-0.4	-0.9	-0.6	-1.0	1.3	-0.9
Progressive ratio test 1 active lever presses	0.3	0.6	1.0	0.8	0.7	0.7	1.0	0.6	-0.9	0.6
Progressive ratio test 1 breakpoint	0.4	0.6	1.1	0.8	0.6	0.7	1.0	0.6	-0.9	0.6
Progressive ratio test 1 inactive lever presses	1.7	4.3	5.9	2.4	2.3	2.0	2.4	1.8	-1.8	1.8
Progressive ratio test 2 active lever presses	0.7	1.0	1.6	1.1	1.1	0.7	1.3	0.8	-0.9	1.2
Progressive ratio test 2 breakpoint	0.8	1.0	1.5	1.0	1.1	0.7	1.2	0.7	-0.9	1.1
Progressive ratio test 2 inactive lever presses	0.7	2.2	3.0	1.4	1.7	1.3	1.7	1.4	-1.2	1.6
Incentive Sensitization - Responses	0.1	0.2	0.6	0.1	0.3	0.2	0.8	0.4	-0.2	0.8
Incentive Sensitization - Breakpoint	0.1	0.1	0.5	-0.0	0.2	0.1	0.7	0.3	-0.1	0.7
Sum of active levers in priming session hrs 5-6	2.1	2.0	3.3	-0.6	-0.4	-1.7	-1.7	-1.6	1.8	-1.3
Progressive ratio	0.5	1.3	2.6	1.4	1.6	1.0	0.1	1.1	-1.1	1.1
Food seeking constrained by brief footshock	0.1	0.1	0.3	-0.6	-0.4	0.0	-0.5	0.1	-0.3	0.0
Seeking ratio, punishment vs. effort	0.3	0.6	1.7	-0.9	-1.3	-0.3	0.2	-0.6	0.5	-0.8
Retroperitoneal fat weight	0.7	3.2	8.2	-2.9	-2.7	-1.3	-1.0	-1.1	0.7	-1.5
Reaction time number correct	0.0	0.1	0.6	0.2	0.1	-0.3	-0.7	-0.3	0.1	-0.3
Reaction time mean minus median	0.1	0.9	4.2	-2.0	-1.0	0.1	-0.6	0.6	-0.3	0.5
Reaction time mean minus median AUC	0.3	1.7	8.0	-2.8	-1.6	-0.5	-1.0	0.2	-0.0	0.3
Reaction time num false alarms	1.3	2.3	4.1	1.8	1.4	1.5	2.0	1.2	-0.9	1.5
Reaction time num false alarms AUC	1.3	2.9	5.5	2.3	1.9	1.6	2.0	1.3	-0.9	1.6
Reaction time trials correct on left	0.0	0.1	0.6	0.2	0.1	-0.3	-0.7	-0.3	0.1	-0.3
Reaction time trials on left	0.0	0.1	0.6	0.1	0.1	-0.3	-0.8	-0.3	0.1	-0.3
Reaction time mean	0.5	1.1	4.9	-2.2	-1.4	-0.3	-0.7	0.2	0.2	-0.0
Reaction time mean AUC	0.4	0.9	4.2	-2.0	-1.2	0.0	-0.4	0.6	-0.2	0.4
Median of all reaction times	0.5	0.7	3.0	-1.7	-1.3	-0.3	-0.4	0.0	0.3	-0.2
Reaction time omissions	0.6	1.0	3.0	-1.7	-0.8	-0.6	-1.6	-0.1	0.6	-0.2
Reaction time false alarm rate	1.6	2.2	4.0	1.9	1.5	1.3	2.0	1.1	-0.7	1.5
Reaction time premature initiation rate	0.1	0.1	0.4	-0.6	-0.2	-0.5	-0.5	-0.2	0.1	0.1
Reaction time premature initiations	0.0	0.1	0.6	-0.4	0.1	-0.4	-0.7	-0.2	0.0	0.0
Std. dev. reaction times	0.3	0.8	3.7	-1.9	-0.7	0.0	-0.8	0.7	-0.3	0.6
Reaction time trials completed	0.0	0.1	0.6	0.1	0.1	-0.3	-0.8	-0.3	0.1	-0.3
Reaction time trials AUC	0.0	0.1	0.4	0.3	0.3	-0.2	-0.6	-0.2	0.1	-0.2
Run reversals in cocaine runway, females	0.7	0.8	1.7	-1.3	-0.4	0.5	0.5	1.0	-1.2	0.8
Run reversals in cocaine runway, males	0.3	0.3	1.5	-1.2	-0.7	-0.1	-0.3	0.3	-0.2	0.4
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.4	0.1	0.1	-0.0	0.0	-0.1	-0.1
Latency to leave start box in cocaine runway, F	0.2	0.2	0.6	0.1	-0.2	-0.4	-0.7	-0.5	0.1	-0.6
Latency to leave start box in cocaine runway, M	0.2	0.2	0.5	0.5	0.3	0.4	0.7	0.3	-0.0	0.3
Std. dev. time between licks in bursts	0.1	0.2	0.8	0.9	0.5	0.1	0.3	-0.1	-0.1	0.1
Total sessions with >9 infusions	0.4	0.5	1.2	0.1	0.6	0.5	0.7	0.8	-1.1	0.9
Short access day 1 total inactive lever presses	0.1	0.1	0.5	0.1	0.5	-0.3	-0.7	-0.0	0.0	0.0
Short access day 10 total inactive lever presses	0.4	2.5	5.2	2.1	2.3	1.3	1.5	1.2	-0.8	1.2
Short access day 1 total infusions	0.9	1.9	3.2	0.8	1.5	1.2	0.9	1.5	-1.8	1.5
Short access day 10 total infusions	0.4	0.6	1.6	-0.8	-0.1	0.6	0.6	1.0	-1.3	0.8
Short access total infusions	0.9	1.3	2.8	0.3	0.8	1.0	1.3	1.3	-1.7	1.1
Short access day 1 locomotion	1.8	2.9	4.1	1.7	2.0	1.7	1.4	1.8	-1.8	1.5
Short access day 10 total locomotion	0.7	3.0	5.1	2.0	2.3	1.6	2.0	1.5	-1.1	1.4
Short access total locomotion	3.0	4.6	6.2	2.1	2.5	2.1	2.2	2.1	-2.1	1.9
One hour access (0.3 mA shock)	0.1	0.2	0.7	-0.1	0.2	-0.0	0.8	0.2	-0.3	0.5
Compulsive drug intake	0.8	1.1	1.7	-1.0	-0.9	-1.3	-0.6	-1.2	1.1	-1.2
One hour access (shock baseline)	0.2	0.4	0.8	0.5	0.4	0.7	0.9	0.6	-0.7	0.7
Social response proportion	3.0	3.8	6.9	-0.8	-1.0	-2.1	-2.6	-2.1	2.5	-1.9
Social responses	1.6	2.1	4.9	-0.3	-0.4	-1.5	-1.9	-1.5	2.2	-1.3
Social time	1.8	2.8	4.4	-1.2	-1.4	-1.8	-1.7	-1.8	2.1	-1.4
Soleus weight	3.6	10.5	15.6	-2.5	-2.8	-3.6	-2.6	-3.6	3.9	-3.2
Bone: stiffness	0.9	1.6	3.8	1.2	0.5	-1.1	-0.8	-1.5	2.0	-1.3
Tibialis anterior weight	1.6	5.6	10.0	-2.1	-1.1	-3.2	-2.9	-2.4	2.8	-1.1
Time to tail flick, vehicle, before self-admin	1.3	1.6	3.6	-0.3	-0.6	-1.6	-0.7	-1.7	1.9	-0.9
Time to tail flick, vehicle, after self-admin	0.0	0.1	0.3	-0.1	-0.2	-0.3	-0.3	-0.4	0.6	-0.2
Time to tail flick, test, before self-admin	0.5	0.6	1.0	0.4	-0.1	-0.8	-0.9	-1.0	1.0	-0.7
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.2	-0.3	-0.1	-0.1	-0.2	0.1	-0.3
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.4	-0.0	0.4	0.9	0.3	1.2	-1.1	0.9
Delta time to tail flick, test, before/after SA	0.5	0.7	1.4	-0.1	0.3	0.8	1.2	0.9	-1.0	0.9
Tibia length	0.5	1.3	3.0	0.5	-0.3	-1.0	-1.0	-1.4	1.3	-1.7
Ambulatory time before self-admin	0.6	1.9	3.6	1.5	0.8	1.7	1.9	1.3	-1.4	0.6
Ambulatory time after self-admin	0.1	0.2	0.7	-0.1	-0.5	-0.4	0.0	-0.6	0.4	-0.8
Bone: tissue strength	1.1	1.1	3.7	1.9	1.5	1.0	0.3	0.8	-0.3	0.3
Total heroin consumption	3.4	4.0	5.5	-1.7	-1.4	-2.3	-2.2	-2.0	2.3	-1.7
Bone: trabecular number	2.7	5.2	9.9	-3.2	-2.5	-2.4	-2.1	-1.9	1.9	-1.5
Bone: trabecular spacing	1.0	1.5	3.3	1.8	1.8	1.1	0.7	1.0	-0.6	0.9
Bone: trabecular thickness	0.1	0.2	0.4	0.2	-0.2	-0.5	0.1	-0.6	0.6	-0.4
Bone: trabecular tissue density	0.7	1.2	2.0	0.9	0.7	1.4	1.3	1.2	-1.1	0.8
Water consumed over 24 hours	0.1	0.2	0.7	0.3	-0.0	-0.3	-0.0	-0.5	0.3	-0.8
Number of responses in last shaping day	2.8	3.6	5.2	1.9	2.3	1.9	1.5	1.9	-2.1	1.7